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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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        <property type="gene ID" value="TDE_2770"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0969">Cilium</keyword>
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            <end position="219"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS13287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="457" mass="50991" checksum="FFA3294BCEE0A30C" modified="2011-07-27" version="1">MQALDVRMQALPVKEPEREDSGDIKRADAEPVRNGDSFLAMIKKMIAAAKDGSKETDEARFEDISLREDKIRDSSLQKEAGRQNTELSSEDHKSKKIDAENLLNSKEAYLKEPKNLLKKPKTETQKPNSEHSQAGKSQKNDLELNLKILNEDFKEEIKDFLPQDVKEDETISLLSDEALKKLDKSEKKKAQSFDDEKTEQAGKLGLLSKADKKDLSKKISPQSEAVQENLSKKPVSKPKLKISVEDLRSMPSVQSDAAIHTTASESRVETDNSVDMVIDFSGKAQNASQGGDLQNTQNGSEAQKTSQTFSAMLAQEIRDASADFVQTGKIVLRDNNAGEIRLHLRPENLGAVKINLELSEGKRVTGTVTVASKEAYDAFEKNLDNLAKEFKQNGFEFAEFNLNWSGFSGQEGFAESFESFSDFVYKNQEQDLRQLEKTADNLSTYSYVYGPTVDILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J17</accession>
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    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="243275.TDE_2759"/>
    <dbReference type="EnsemblBacteria" id="AAS13276">
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        <property type="gene ID" value="TDE_2759"/>
    </dbReference>
    <dbReference type="GeneID" id="2740726"/>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.2603"/>
    <dbReference type="eggNOG" id="ENOG502ZPK4">
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    <dbReference type="HOGENOM" id="CLU_1175012_0_0_12"/>
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    <dbReference type="Proteomes" id="UP000008212">
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="236" mass="28549" checksum="AF7275EF51606D9D" modified="2004-07-05" version="1">MTIKEIITEINKIEIDIVDFISSYRSERLVSNYNDWNYKDVIAHLLEWIMFSKNKLNAIVHNQDFQEINNIDIFNKQNYIKNKNRHIIELQKKLIFELNEYKNIVLLYTEADLQRKDLPIGFSFELWRYMVMDTIIHPVMHLLYYLIKTKNYKLFFKLCKKYNDIFYCYAKGNLEVYSFYEYIEDSKKFIENIKELGEQYKNDDMIHAVLKANKIDGTSNTRTSTLTFVLDEMIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J69</accession>
    <name>Q73J69_TREDE</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AAS13224">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="300" mass="35111" checksum="CDBF3BA4C75ADF7A" modified="2004-07-05" version="1">MKQLFKITLRNDYAFKRVFGVEENKDVLQDLLECILDIPPETIADLELLDKEFQKELLSEKLGVLDIKLKLKDGTFVDIEIQNSWHFDFPERTLYYWSKMYNENIKQGQDYTKLPKCITINLIGKGFNKNKRLHNKYLVLEQYTKEPLASKLEIHILNLAKARLLEGSQFRDKKTKRLLNWLKFIETDNPEVRKMLAQESTMMKKANDTITIMEMSPRDKWLYESRMKYEHDRASCINEGYRQGIEVGILQGEIKGRQEGFADGSYQTKLETAKLMKGMNYPISDICTVSGLSKEEIDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
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    <name>Q73J96_TREDE</name>
    <protein>
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            <fullName evidence="4">Uncharacterized protein</fullName>
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        <name evidence="4" type="ordered locus">TDE_2679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="NP_973277.1">
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    </dbReference>
    <dbReference type="RefSeq" id="WP_002680721.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13196">
        <property type="protein sequence ID" value="AAS13196"/>
        <property type="gene ID" value="TDE_2679"/>
    </dbReference>
    <dbReference type="GeneID" id="2739266"/>
    <dbReference type="KEGG" id="tde:TDE_2679"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2531"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046535_2_0_12"/>
    <dbReference type="OMA" id="TVTIEFY"/>
    <dbReference type="OrthoDB" id="1977328at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025645">
        <property type="entry name" value="DUF4349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14257">
        <property type="entry name" value="DUF4349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284537" evidence="3">
        <location>
            <begin position="27"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS13196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="294" mass="33601" checksum="F7086445DA78C368" modified="2004-07-05" version="1">MKKKAFIFLCLSLVLNLFLSCGGKKAAYETGKSTRAESYMAESKSSSSDSAFKEDKKESDAVNTASLDNDNIERKLIKTGFIEFETEDIKKTRETIENLVTKYQAYISQEDEQHFQSNIRQTISIRIPKENFDNLLNELTIGIKKLDNKNITVEDVTEEFVDGLARLKVKKETEQTYLKILSQAKTVKDILEVQNQIQDLRSDIEAIEGRLRYLQKSVNYSTLNISMYQIINSSIARPSFFTKALNAVKEGIGLFSDIIIGILYLWIFILIIIAVAVIIIKKRRNKIKEKSLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J99</accession>
    <name>Q73J99_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonine synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973274.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673523.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2676"/>
    <dbReference type="EnsemblBacteria" id="AAS13193">
        <property type="protein sequence ID" value="AAS13193"/>
        <property type="gene ID" value="TDE_2676"/>
    </dbReference>
    <dbReference type="GeneID" id="2741121"/>
    <dbReference type="KEGG" id="tde:TDE_2676"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2528"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015170_0_0_12"/>
    <dbReference type="OMA" id="PTGVFKD"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thr_synth_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="437" mass="48980" checksum="956DCBC0355F4FB8" modified="2004-07-05" version="1">MDLVSTRNNNKIVSFYEAVTNCMPADGGLYIPKEALDLSDWTYHLNETSSFTSITGALTSAILREEFSPAVSERIAVSAFGNYSPRVRQLDERLFLLDLFHGPTGCHRDFGFLWFASVLEHILTITDKKAIVLGTGTKKNGQSMAAAFWNKKRVKTLLIHPKGYASGIPEEYLAENGGSIYSVECEGDVKDVENLKRSVYLDRNLVEKYGLTLANTVNIGRLLPQIFFYFYAFTRFKKHIFGEIYYALHSGNYGNLAAGLFAWKSGLSLNGFITDSTPELSVNKDGDCFCKTMEIPLSQRSAADPVSPSNIERLEQIFEISPAIMKALIFPKQVDPKDYKELIRKAYQRYGIMIDTSTAAAYGAAIKSKILKNKGPETLVLISKDHPAFEADIIEEACGEKPNQPEYMSGLDKPIKNIKKIQASKKEIENMLEYMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JB1</accession>
    <name>Q73JB1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973262.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13181">
        <property type="protein sequence ID" value="AAS13181"/>
        <property type="gene ID" value="TDE_2664"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2664"/>
    <dbReference type="HOGENOM" id="CLU_3359079_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="36" mass="4359" checksum="269DE826B2BF7215" modified="2004-07-05" version="1">MYNASDNLKNSKSLIFFQKNYSIKKFIFEVIYGFFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JB2</accession>
    <name>SYI_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="1">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ileS</name>
        <name type="ordered locus">TDE_2663</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973261.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680710.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JB2"/>
    <dbReference type="SMR" id="Q73JB2"/>
    <dbReference type="STRING" id="243275.TDE_2663"/>
    <dbReference type="PRIDE" id="Q73JB2"/>
    <dbReference type="EnsemblBacteria" id="AAS13180">
        <property type="protein sequence ID" value="AAS13180"/>
        <property type="gene ID" value="TDE_2663"/>
    </dbReference>
    <dbReference type="GeneID" id="2741108"/>
    <dbReference type="KEGG" id="tde:TDE_2663"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2517"/>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_12"/>
    <dbReference type="OMA" id="HLGTAWN"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000098568" description="Isoleucine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="626"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <sequence length="1100" mass="125760" checksum="90A17F4C6F320E8D" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JD1</accession>
    <name>Q73JD1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridine nucleotide-disulphide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973242.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680674.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2644"/>
    <dbReference type="EnsemblBacteria" id="AAS13161">
        <property type="protein sequence ID" value="AAS13161"/>
        <property type="gene ID" value="TDE_2644"/>
    </dbReference>
    <dbReference type="GeneID" id="2741089"/>
    <dbReference type="KEGG" id="tde:TDE_2644"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2499"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030705_0_0_12"/>
    <dbReference type="OMA" id="HPGFGLH"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="442" mass="47778" checksum="94BC8CE3A83F6CAC" modified="2004-07-05" version="1">MININDKKDCSNCNDEYEVAVIGGGPAGLAAALEAKKNGASSVLIVERDFELGGILNQCIHAGFGLHEFKEELTGPEYAERFINMVKKEDIDILLNTMVIDLTKEREITLIGAQGLKKIKAGAVVLAMGCRERTAGAIALKGYRPSGVFNAGMAQRLMNIEGFSVGKEVVIYGSGDIGLIMARRMTLEGAKVKAVVEIMPYSSGLNRNIAQCLEDYGIPLFLSHSISCVHGKDRVTGVTIAQIDSSFKEIPETEKEFSCDTVLLSVGLIPENELTQKAGIAINPITNGAFVDNGMETETSGIFACGNVLHVHDIVDFVTKESRTAGKNAALFTQKNKKGESTENKFGTNSSGSTFIKTTAKKGIRYIVPNKINTGNIDGASLFMRVDSVYKNARLIIKSGEQILAQKKTSQMVPSEMINIPLNFITLRGLTQDITAEVILDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JE4</accession>
    <name>Q73JE4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2631</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973229.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680652.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2631"/>
    <dbReference type="EnsemblBacteria" id="AAS13148">
        <property type="protein sequence ID" value="AAS13148"/>
        <property type="gene ID" value="TDE_2631"/>
    </dbReference>
    <dbReference type="GeneID" id="2740805"/>
    <dbReference type="KEGG" id="tde:TDE_2631"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2487"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_8_0_12"/>
    <dbReference type="OMA" id="LWPEMAP"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS13148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="274" mass="29845" checksum="21E61E29096B21DB" modified="2004-07-05" version="1">MKNPRNTLPYVPCLFLLAVVCAACLPYFPFLKSGTVPSGQALCPPSSEHWFGTDDLGIDLFASVCYGAKSSLLLSVGSALVAAIGGSIIGMLAGYAGGAVDALIISIIDFFIGIPDLLLMVVLGVFLGPGLVNIIFAISLVSWVMPAKIVRSEVLKMKTEPYIRLSKVYGAHFWHIFAWHFWKPLFSIMLVSVIKIMNKAILAEASLAYLGLGDPLSKSWGMTITRAMDFPNIYLTDFWKWWLVFPTAVMVCTVLSVAAIGRRMELSIGGRTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JG7</accession>
    <name>Q73JG7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973206.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680601.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2608"/>
    <dbReference type="EnsemblBacteria" id="AAS13125">
        <property type="protein sequence ID" value="AAS13125"/>
        <property type="gene ID" value="TDE_2608"/>
    </dbReference>
    <dbReference type="GeneID" id="2740782"/>
    <dbReference type="KEGG" id="tde:TDE_2608"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2466"/>
    <dbReference type="eggNOG" id="COG1426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_743750_0_0_12"/>
    <dbReference type="OMA" id="VFRASMR"/>
    <dbReference type="OrthoDB" id="2071222at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="372" mass="42070" checksum="0878E79C181BCA79" modified="2004-07-05" version="1">MNEIGKLLTETRIEKDLELDQVARETNIAKRYLEALESDDYSVFPAEPYIVGFLRNYCEYLDLDPEEITNLYKQIKIQETSLPPDALLEKRGFALSKPLIIGFGVLAAIAVIITVVFFAFKSWIPAIQQKRSQANVGTEVREKREAKTHEISQKKYEQRIFEGDVLKLTIEDKEYKIEVEKVSPKLNLKTETGNQIISLGQTVKIDLNNDLIPDVEITLEDIDKNNPESGALVSILTGNSISEGKPSTETDLVVSEDDSQAAATYKVLFESGSAYPVTLNATFRGYCLFRYEADRTNREERYYQKAEQLTVQANNGLRIWASNGNAVKLQVVAGGKTVDLEVSRPGEVIVKDLKWIRDDETKRFKFIVVDVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JR1</accession>
    <name>RS21_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsU</name>
        <name type="ordered locus">TDE_2473</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973071.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673965.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JR1"/>
    <dbReference type="SMR" id="Q73JR1"/>
    <dbReference type="STRING" id="243275.TDE_2473"/>
    <dbReference type="EnsemblBacteria" id="AAS12990">
        <property type="protein sequence ID" value="AAS12990"/>
        <property type="gene ID" value="TDE_2473"/>
    </dbReference>
    <dbReference type="GeneID" id="2739658"/>
    <dbReference type="KEGG" id="tde:TDE_2473"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2339"/>
    <dbReference type="eggNOG" id="COG0828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159258_1_2_12"/>
    <dbReference type="OMA" id="FKRSCQK"/>
    <dbReference type="OrthoDB" id="2088764at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018278">
        <property type="entry name" value="Ribosomal_S21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01181">
        <property type="entry name" value="RIBOSOMAL_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000178396" description="30S ribosomal protein S21">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <sequence length="69" mass="8502" checksum="0D0698EE6C4B055C" modified="2004-07-05" version="1">MAYVTIDDSEHLEKALKRFKRQVEKEGIIREWKKKEFYEKPSTVLNRKNKALRRKLMKKTRRSRDSKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JT2</accession>
    <name>Q73JT2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-seryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="5">2.9.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Selenocysteine synthase</fullName>
            <shortName evidence="5">Sec synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">selA</name>
        <name evidence="7" type="ordered locus">TDE_2477</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22728"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SelA family.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.1" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973075.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680443.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2477"/>
    <dbReference type="EnsemblBacteria" id="AAS12994">
        <property type="protein sequence ID" value="AAS12994"/>
        <property type="gene ID" value="TDE_2477"/>
    </dbReference>
    <dbReference type="GeneID" id="2741450"/>
    <dbReference type="KEGG" id="tde:TDE_2477"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2343"/>
    <dbReference type="eggNOG" id="COG1921">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038142_1_0_12"/>
    <dbReference type="OMA" id="GATNRTH"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004125">
        <property type="term" value="F:L-seryl-tRNASec selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00423">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004534">
        <property type="entry name" value="SelA_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00474">
        <property type="entry name" value="selA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0711">Selenium</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5 6">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618319-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="448" mass="48928" checksum="FA91F4BD4CD3CAAD" modified="2004-07-05" version="1">MAKENTNPLARIPQVEKLLNEGILKNTAALIGRPFVVKKASEYLEDIRKKARAGGDVPLLKACAEEICKLCRPIIRTKITPVINATGIILHTNLGRSPLPENIWDRAKETASGYSSIEMDLRDGNRGKRFEFLNDCMSLLTGAEDALILNNNAAAVFLMLKALAGGKEVIVSRGQQVQIGGGFRIPEILEMAGCKLIEVGTTNITSLKDIQKAINENTAMVLWVHTSNYKIRGFTEQPSISEIKAILPQNIILAVDQGSGNLSLNVPEEPTVSSIIKEGADLVCFSGDKILGGPQAGWIVGKKNLVQTVAKNQLMRTYRVGRAVASLMQECLILYLNGGESAAQRALLLDQKKIKKRAEKIIASLKSGAGELVQKNFSLGGGSTPDTGFSSWAVKLNTKKPCEKLKTNLREMPIPIIGFIEEDSFYIHPASIEEKYDEYVIEALNKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JU5</accession>
    <name>Q73JU5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">priA</name>
        <name evidence="11" type="ordered locus">TDE_2490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973088.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680463.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2490"/>
    <dbReference type="EnsemblBacteria" id="AAS13007">
        <property type="protein sequence ID" value="AAS13007"/>
        <property type="gene ID" value="TDE_2490"/>
    </dbReference>
    <dbReference type="GeneID" id="2741463"/>
    <dbReference type="KEGG" id="tde:TDE_2490"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2356"/>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013353_4_1_12"/>
    <dbReference type="OMA" id="RCHYCGY"/>
    <dbReference type="OrthoDB" id="1132322at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="141"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS13007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="660" mass="73628" checksum="CC22AACB249085F9" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JU9</accession>
    <name>Q73JU9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_2512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973110.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675966.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2512"/>
    <dbReference type="EnsemblBacteria" id="AAS13029">
        <property type="protein sequence ID" value="AAS13029"/>
        <property type="gene ID" value="TDE_2512"/>
    </dbReference>
    <dbReference type="GeneID" id="2739024"/>
    <dbReference type="KEGG" id="tde:TDE_2512"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2378"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_12"/>
    <dbReference type="OMA" id="RHGKRWM"/>
    <dbReference type="OrthoDB" id="293754at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="8">
        <location>
            <begin position="3"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 6">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS13029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="457" mass="51618" checksum="45084DA046E927EE" modified="2004-07-05" version="1">MNQDIETIVKNCRIFFETNKTKSYEFRISQLLKLQEVLNQNKKELLNALYSDLHKTEMEGFFSEFAIVRGELKFAIKHLKKWIKPKRVPTSIAHFKSSSKIMYEPFGTVLIMSPWNYPLNLTLAPLVGAIAAGNCAVVKPSNYSPATSEVIKKIISENFPPEYISVITGGREENSKLLEQRFDYIFFTGGTTVGKLVMEAAAKYVTPVTLELGGKSPCVVEKSANLKVAARRIAFGKYLNAGQTCVAPDYILIQDEVKEKFIEELKEALKEFFPTETYLDMHLPHIVNEKHFDRLMGLIEGEKIITGGKGEKGRKFIEPTVLDNITFDSKIMQEEIFGPILPVISFKTIEEAIKLIKSREKPLASYLFTTDSNIEKKFLNEVSFGGGCINDTIVHLASDYLPFGGVGFSGIGKYHGDESFKVFSNAKSILKKSNLIDIKLRYHPYSEKKLNIINKMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JX4</accession>
    <name>Q73JX4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973137.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680506.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2539"/>
    <dbReference type="EnsemblBacteria" id="AAS13056">
        <property type="protein sequence ID" value="AAS13056"/>
        <property type="gene ID" value="TDE_2539"/>
    </dbReference>
    <dbReference type="GeneID" id="2739051"/>
    <dbReference type="KEGG" id="tde:TDE_2539"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2402"/>
    <dbReference type="eggNOG" id="COG1355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_956267_0_0_12"/>
    <dbReference type="OMA" id="WHTASGI"/>
    <dbReference type="OrthoDB" id="1070303at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285803" evidence="2">
        <location>
            <begin position="22"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="294" mass="33753" checksum="6C8F861BDE854643" modified="2004-07-05" version="1">MKVIKFIITVFFICFCLTACTGKKDETEETEKIFRTWSSDGEKPPKTRFIPKEASLPDGAKPWGGTVSHHLLTDALIDDWFTDLAEARTIKTFYILSPSHWGLSLYDFSLTKGSWQTKDGLVNSAKDKVENLSRLFDVPFDDKVFVYEHGVSTLIPYIKKYFPDAKVVAIAYYGEPPVNMSLATKLYETVTKVFSIKDKEAFLLISSDFSHKSDMEKTAEKDAKSRYFLTSLKPSAWTLGICDNRPAMYLLSKLFTEKTQCTIQRNTNAYKLSDETDPEDITSYFFTYFWEKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K44</accession>
    <name>Q73K44_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972977.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680301.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2378"/>
    <dbReference type="EnsemblBacteria" id="AAS12896">
        <property type="protein sequence ID" value="AAS12896"/>
        <property type="gene ID" value="TDE_2378"/>
    </dbReference>
    <dbReference type="GeneID" id="2739987"/>
    <dbReference type="KEGG" id="tde:TDE_2378"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2246"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="NVFQQCV"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="312" mass="34555" checksum="AF1A11FCFEC81783" modified="2004-07-05" version="1">MKILEVKDVSKKYGKKQVLSGVSFDIEEGDIFGLIGPNGAGKSTLINIITGILDPLNGEVLIGGHSIKKKPIEAKKLIGLVPQELALSEDISAIDNLNFFASLYGLSGKKLKEAVNEALEVVGLTEKKKEKVKKFSGGMKRRLNLAAAIMHKPRLLILDEPTVGIDPQSRNNIFEYLRKVNSQDKTTILYTSHYMEEVEELCKNIFVIDEGREIAYGSLNSVKEKANGTVTIEIKADNINEDLIEKIRLLDGALNVEKEANTLNILYERSKVNLDELIKILQTSGAVIKAIQINELNLGEVFLQLTGKKLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K82</accession>
    <name>Q73K82_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972937.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12856">
        <property type="protein sequence ID" value="AAS12856"/>
        <property type="gene ID" value="TDE_2338"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2338"/>
    <dbReference type="HOGENOM" id="CLU_3399008_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="31" mass="3551" checksum="010F977451A39BCB" modified="2004-07-05" version="1">MGNVHPESDFHLIENIVKTTGLSREEIEKIN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KH5</accession>
    <name>CUTC_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PF03932 family protein CutC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cutC</name>
        <name type="ordered locus">TDE_2243</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972843.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674428.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KH5"/>
    <dbReference type="SMR" id="Q73KH5"/>
    <dbReference type="STRING" id="243275.TDE_2243"/>
    <dbReference type="EnsemblBacteria" id="AAS12762">
        <property type="protein sequence ID" value="AAS12762"/>
        <property type="gene ID" value="TDE_2243"/>
    </dbReference>
    <dbReference type="GeneID" id="2741348"/>
    <dbReference type="KEGG" id="tde:TDE_2243"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2117"/>
    <dbReference type="eggNOG" id="COG3142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050555_3_2_12"/>
    <dbReference type="OMA" id="FHRAFDQ"/>
    <dbReference type="OrthoDB" id="1728422at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="Cu_homeostasis_CutC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="PTHR12598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="SSF110395"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000215077" description="PF03932 family protein CutC">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00795"/>
        </source>
    </evidence>
    <sequence length="246" mass="26811" checksum="4D03176C6836B111" modified="2004-07-05" version="1">MKNIKIEICAGSFEDAVLAEKAGASRIELNSSLFLGGLTPSLGTLKLVKKETHLEVMAMVRPRAAGFFYSSYEYKTMLEDAKLFIDNGADGLVFGFLKKDGTIDAKRCEALIKIAESRDKVFHRAIDVVPDPLKALDELISLGFTRVLTSGQEPTAYEGADLIAKMVKRAKGRIEILPGGGITEKNASKIIKLTGVDQIHFAALKRREEPSTKANPSIYYGGALYPPEDSIEVAGLDEMTKVIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KH8</accession>
    <name>Q73KH8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972840.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2240"/>
    <dbReference type="EnsemblBacteria" id="AAS12759">
        <property type="protein sequence ID" value="AAS12759"/>
        <property type="gene ID" value="TDE_2240"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2240"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2114"/>
    <dbReference type="eggNOG" id="ENOG5031C8C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086381_0_0_12"/>
    <dbReference type="OrthoDB" id="1319581at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="265" mass="29583" checksum="943370F875FB8E74" modified="2004-07-05" version="1">MILIFLGLVGAGTLVVYQKLPAGQSSGSPVGHPAGEQAELSKTETAELEKPKQETENTEPKKELKKEEPKRVVPIKTPRKEVPKKAEPKKIEPKKASKEKESEVSAKPSMGISLADRDKKTFNWSLGLLAEANMNSPDGYAMGTGLYTLFMLPLKLKIGHLSLGARTLYSNDFKKHHIFDAALLFRWNFYDFSKIKERDSGFFIQLEGGAVFGLKEREPSKLFMYALGEAAFGYRFTINNFFIEPYLRGGYPVIWAIGISGGFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KK8</accession>
    <name>Q73KK8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1565 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972810.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680054.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2210"/>
    <dbReference type="EnsemblBacteria" id="AAS12729">
        <property type="protein sequence ID" value="AAS12729"/>
        <property type="gene ID" value="TDE_2210"/>
    </dbReference>
    <dbReference type="GeneID" id="2739486"/>
    <dbReference type="KEGG" id="tde:TDE_2210"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2087"/>
    <dbReference type="eggNOG" id="ENOG5033S2C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037848_0_0_12"/>
    <dbReference type="OMA" id="VERCRYE"/>
    <dbReference type="OrthoDB" id="264258at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011459">
        <property type="entry name" value="DUF1565"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07602">
        <property type="entry name" value="DUF1565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285930" description="DUF1565 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1565" evidence="2">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="435" mass="47868" checksum="D1B6154A0A1A39DB" modified="2004-07-05" version="1">MKKGIITCLLAVLVLANLTAAEYYVSKETGKNGNAGTKDAPFKNIEKAVEKVQPGDKIYVAEGNYYGVRDKGFIMIQKAVEIYGGYSKDFSKRDVLKYRTLVMPPASSNGTGRANKAMEFDIKNGEGKKLVIDGIIFDKGLSNGYHPTKGKPQGVETGMLVLPPGQGVNGNEKSITTEKAIFGGSIMKCDVLIQNCVFNNASNFAIQFGGTGNVKILNNVFTANAMAACEIWGKENKPNAITVEFAYNTVLFTWPRTHAFEDMGYGFRVMTKVEVNIHHNIIGLSCLSAVDRCRIDSPASMENGRKVLMDNNRFFMNKQADVTLPGLGTFEYVWVKDFDDLDRFNSAEGNEELKDIASLKNVLNKAYLAGFLNATYKEKTDYDPNSPANEFRRAMGMNQTMTVQSDVSMFANKYPQDDAVKLFGAVKGFGAQAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KL6</accession>
    <name>Q73KL6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972802.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2201"/>
    <dbReference type="EnsemblBacteria" id="AAS12721">
        <property type="protein sequence ID" value="AAS12721"/>
        <property type="gene ID" value="TDE_2201"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2201"/>
    <dbReference type="HOGENOM" id="CLU_3241003_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="43" mass="5098" checksum="218AB07884BE4541" modified="2004-07-05" version="1">MKSSMSVIVKFYLLNSLFYLFFLLSVVFNFFDFYACVNKINAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KR1</accession>
    <name>Q73KR1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">infC</name>
        <name evidence="8" type="ordered locus">TDE_2156</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972757.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957166.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2156"/>
    <dbReference type="EnsemblBacteria" id="AAS12676">
        <property type="protein sequence ID" value="AAS12676"/>
        <property type="gene ID" value="TDE_2156"/>
    </dbReference>
    <dbReference type="GeneID" id="2739142"/>
    <dbReference type="KEGG" id="tde:TDE_2156"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2037"/>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054919_3_2_12"/>
    <dbReference type="OMA" id="RNMIMFL"/>
    <dbReference type="OrthoDB" id="1760144at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="87"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="175" mass="19931" checksum="3420EAA29714135C" modified="2004-07-05" version="1">MAEVKGLRINDQIRVREVRLIGVNGEQAGIVPTIEAVKMAAEAGLDLVEVAPTAKPPVCKIIDYGKYRFQMEKKLRDSKKNQKQQMMREIRMQPKIHDHDLEFKSSHIKKFLDGGDKVKVTVRFWGRELAHTELGYEVLNKVLEKLGGEEACTLEKKPAMEGRTMSMTLSPKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KS0</accession>
    <name>Q73KS0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972748.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679984.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2147"/>
    <dbReference type="EnsemblBacteria" id="AAS12667">
        <property type="protein sequence ID" value="AAS12667"/>
        <property type="gene ID" value="TDE_2147"/>
    </dbReference>
    <dbReference type="GeneID" id="2739133"/>
    <dbReference type="KEGG" id="tde:TDE_2147"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2028"/>
    <dbReference type="eggNOG" id="ENOG5032BIC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120991_0_0_12"/>
    <dbReference type="OMA" id="DRGDEQT"/>
    <dbReference type="OrthoDB" id="554994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285816" evidence="1">
        <location>
            <begin position="32"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="153" mass="17524" checksum="785495FD5ED15955" modified="2004-07-05" version="1">MTKKIKTRFYVFNLLILTAAISLLFSCSSLPTDETVPANLTPIELNQRAQAELDNGSLRNALEYYKIVIKRYGTDASTRTAAEYEIAHIYISQKKWLEADDMLKAIIDRYEMAGGAGLAPKYLVLARKDYKRTQEYIQKHNLRKTKAKSEEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KS2</accession>
    <name>Q73KS2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972746.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679979.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2145"/>
    <dbReference type="EnsemblBacteria" id="AAS12665">
        <property type="protein sequence ID" value="AAS12665"/>
        <property type="gene ID" value="TDE_2145"/>
    </dbReference>
    <dbReference type="GeneID" id="2739131"/>
    <dbReference type="KEGG" id="tde:TDE_2145"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2026"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_1_0_12"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="366" mass="41503" checksum="BCF6E94951A597E7" modified="2004-07-05" version="1">MHFFKQFLKKIKNMDPYSRANIFYLILAVAIIGSILFFTREKIINYPYDSIENFKTMISVTKKPVTVIGKGDDGVFLEGRSITLSPYKIGKYEVAFSFWHEVYNWAVTESKHKYVFQSMGQPGIFMTSGSDPDDLYEIADVRKKAESLGLPYETVKCGLYPVTKMSWSDAIIWCNALSEKEGLDPVYFYDGQVLRSSLEITKTENPEVRMKNNGYRLPTEAEWEFAARGGDVSAPDWDFGFAGTDDFNAADDYAWHSGNSSFLNAGAITEIIDIHPIGQKKPNRLGLYDMSGNCWEWCFDRYNSRLPGEFIDPINNMGARPRIIKSGSARNPPAFARVKSWGYATPVNPGYILGFRLAQTIVKDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KT1</accession>
    <name>Q73KT1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972737.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12656">
        <property type="protein sequence ID" value="AAS12656"/>
        <property type="gene ID" value="TDE_2136"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2136"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2017"/>
    <dbReference type="HOGENOM" id="CLU_057504_4_3_12"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="89" mass="10590" checksum="CDF227D981574D98" modified="2004-07-05" version="1">MKKLFKITLRNDYAFKRVFGTEENKDVLQDLLECILDILPEDIAGLELLDKEFHKDSISDKTGSYTRKSVLALKLRWLYASKFRWLYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KX8</accession>
    <name>Q73KX8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">ffh</name>
        <name evidence="10" type="ordered locus">TDE_2089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="8">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972690.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668253.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2089"/>
    <dbReference type="EnsemblBacteria" id="AAS12609">
        <property type="protein sequence ID" value="AAS12609"/>
        <property type="gene ID" value="TDE_2089"/>
    </dbReference>
    <dbReference type="GeneID" id="2740328"/>
    <dbReference type="KEGG" id="tde:TDE_2089"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1973"/>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_12"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="9">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="189"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="247"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS12609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="443" mass="48824" checksum="812426CD6FBDECE9" modified="2004-07-05" version="1">MLENITEKFSGIMRSLSGKSKITEKNIEDTIEEIKTALLDADVNLRVVRRFINATAEEAKGERVLKSVDPGQQFTKIVYDKMTSFLGDEKKALDLRGPDTQSVILFLGLQGSGKTTSAAKLALKLKNEGRKPLLVACDLIRPAAVEQLSVLGGNISVPVYKEETKDAVKVAKNALAFAKKNFYDTVIVDTAGRLQIDEDMMKEIVNIKSAVKPMETILVADSMTGQSAVDVAKEFDEQVGLSGLILTKFDSDTRGGAALSLKTITGKPIFYIGTGEKLEDLEPFYPDRIASRILGMGDIVSLVEKAQALYDEEEAEKLQKKMQSESFSLADMLMQLEQAEKMGPLESMLDMIPGLSGQIDKDKLDLSLLKRQKAIIQSMTLKERDNFRIIGPPRRKRIAKGSGTSVGDVNKLLKQFEKTRQMMRKVSKNKGLQAKMMSGGLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KZ1</accession>
    <name>Q73KZ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972677.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957142.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2076"/>
    <dbReference type="EnsemblBacteria" id="AAS12588">
        <property type="protein sequence ID" value="AAS12588"/>
        <property type="gene ID" value="TDE_2076"/>
    </dbReference>
    <dbReference type="GeneID" id="2741203"/>
    <dbReference type="KEGG" id="tde:TDE_2076"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1961"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043127_0_0_12"/>
    <dbReference type="OMA" id="QVAMFIG"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284570" evidence="1">
        <location>
            <begin position="22"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="492" mass="55825" checksum="B1727BD2698892AB" modified="2004-07-05" version="1">MKILKLFVFCIVYLLISSCNRSVSEGNSGKYDIDKVLNKSEPITINIWHYYGATQKEKFDNLIDNFNASEGAKYGVYVRSIRRAGNASEISSFLADALSQKLGADEIPDIFSAYPDTAYDFNQQDLLLDLADFFTEKEKDEYVKSFLYSSGFGVKDEIKLFPVAKATEVFVLNKTAWTPFAEAMGVSYRDLVTWEGLVKVAELYYKWTDSLTAEPNDGKPFFGRDALSNYILVGTYELGNSIFNVLENGDVEFVLDKKTLRTCWDNYYVPFVKGFFTAKGRFRADDLKTGDIISCVTSTSSAIYLPAKVMDSAGNSTFIDLDVLPIPHFRNAKRKTIVQQGAGMAVLKSDIKRETAAVLFLKWFTEMQKYSEFAVSTGYLPVKKKELETESLTAAFCTDDTCILPVMQDALKISMETMKSLDLYFQPAFKNSDKARNILADLLQERAKRDRAKVLEKIQAGKTHKEAVDEFLNDNVFEEWLKELEKRLFDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L00</accession>
    <name>Q73L00_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">xseB</name>
        <name evidence="5" type="ordered locus">TDE_2066</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972668.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674672.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2066"/>
    <dbReference type="EnsemblBacteria" id="AAS12579">
        <property type="protein sequence ID" value="AAS12579"/>
        <property type="gene ID" value="TDE_2066"/>
    </dbReference>
    <dbReference type="GeneID" id="2741193"/>
    <dbReference type="KEGG" id="tde:TDE_2066"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1950"/>
    <dbReference type="eggNOG" id="COG1722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145918_3_0_12"/>
    <dbReference type="OMA" id="IEILMNG"/>
    <dbReference type="OrthoDB" id="2057189at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="78" mass="8986" checksum="0DFB1D0B40FD4FA5" modified="2004-07-05" version="1">MKKFEERLEKLEKISDDIRSSDIPLEKALSLFEEGIKLAKGLEKDIEKMEGKIEVLLNQPVLPEEEPELDLFTVTETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L31</accession>
    <name>Q73L31_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972637.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675474.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2034"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12548">
        <property type="protein sequence ID" value="AAS12548"/>
        <property type="gene ID" value="TDE_2034"/>
    </dbReference>
    <dbReference type="GeneID" id="2740628"/>
    <dbReference type="KEGG" id="tde:TDE_2034"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1919"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_0_12"/>
    <dbReference type="OMA" id="FFCPNAG"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="385" mass="44413" checksum="CA2353D06413E4F1" modified="2004-07-05" version="1">MKIGIFTDCYYPQINGVVTSTMNLQKELEKLNHEVYIITTTFPNFKDEDEKHIIRIPSIPFFKWSEFRIGLFLKHTKAYNKVKALNFDIVHTQTEFSMGNFGTFIAKDLNIPCIHTYHTVYEEYTHYISNFGKSPLKKVVRKLSKRYIAHFSGVIAPTEKTRDLLISYGVKNKIYVVPTGINLEKFKKDIPDAETNSLLKSFNIKKDSFKLIFLGRISKEKNIETLINIMPKIVSENNNIQLIIVGDGPDRLELEERVRYLDLQDNVIFTNRIPNDKVPIYYKAADLFISPSKTETQGLTILEAMAAGVPVLVYDDTNIKGLVLHKKTGLLFKENDELLDNIKFALNNKEEIQSYAKEAFKIAEDFSSANFAKKVERIYKELINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L42</accession>
    <name>Q73L42_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
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        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="190"/>
        </location>
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        </location>
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        </location>
    </feature>
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            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12537.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="369" mass="43530" checksum="BFE1A370E1DDC31F" modified="2004-07-05" version="1">MKKIIFVILVPIVLYEFISCNSIPNSEITEKDSFIIYQMNLSKYERQIEKDPNNYKLYYVRGYYYSLSGYYDLAIHDINRSLKINPNYEESILLRGLIFYAMMKYNEAIVDFSRVIELIPNDPRAYNNRSSCYLEFGDFEKALCDINSAIKLDPKDSLHFKNRGEIFYRLKDYDNAILNYTQALKLNPRDSDAYFSRGLFYETIKDYNSALSDYYKALKLKYRSNDIYFHIGLSCYALKEYDNAINAFNKYIKINNTDAEAYTWRGSIYFILKNYDNSIKDLDMAINLGGSNEVVFYNKAVALYSKNELNEAIDCLEEGINLFPDYYDFYQVKAKIYRSLSEQTKDEYQKGMFLKLANDCEVVYNSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L58</accession>
    <name>Q73L58_TREDE</name>
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        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="250"/>
        </location>
    </feature>
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        <location>
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            <end position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="15"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="326"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
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            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS12521.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="580" mass="63115" checksum="B736A18A286C533A" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L75</accession>
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        </submittedName>
    </protein>
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        <name evidence="6" type="ordered locus">TDE_1990</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS12504">
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
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        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
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        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
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        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="31"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="709" mass="80623" checksum="2412A3155AAF1FEE" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LD6</accession>
    <name>Q73LD6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972532.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679630.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73LD6"/>
    <dbReference type="STRING" id="243275.TDE_1929"/>
    <dbReference type="EnsemblBacteria" id="AAS12443">
        <property type="protein sequence ID" value="AAS12443"/>
        <property type="gene ID" value="TDE_1929"/>
    </dbReference>
    <dbReference type="GeneID" id="2740169"/>
    <dbReference type="KEGG" id="tde:TDE_1929"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1824"/>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083337_0_0_12"/>
    <dbReference type="OMA" id="TSWYFEL"/>
    <dbReference type="OrthoDB" id="1605287at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="285" mass="32068" checksum="CC30C91CE8FC6698" modified="2004-07-05" version="1">MKKNLYIFLFFMTFLYSYSFEWPVENPSLLRLFAQRNDAFVSRSLVFKEVDTVRASGYGKHIISIEEKNSTRFFPSTLGNAMIFIDDEGLQSIYANLSDTDLFTSRKETEAGSILGYAGKSAWTEEKSLIFQVADTRNNVLINPLLFMPAIEEKTEPQIQNTVLINGDKQTISLETVKKIKQGSYDLYSSISDSTEKGGPQLAPFRITVSINGMNISDLPFEVLSSDGKDLYLQNKKSSLSLLYEKEGTMHLGKINLPAGKIELIITVLDKSGNQKKASFIFQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LH5</accession>
    <name>Q73LH5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972491.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669698.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1888"/>
    <dbReference type="EnsemblBacteria" id="AAS12402">
        <property type="protein sequence ID" value="AAS12402"/>
        <property type="gene ID" value="TDE_1888"/>
    </dbReference>
    <dbReference type="GeneID" id="2739117"/>
    <dbReference type="KEGG" id="tde:TDE_1888"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1789"/>
    <dbReference type="eggNOG" id="COG1664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072799_4_2_12"/>
    <dbReference type="OMA" id="EFEGYIE"/>
    <dbReference type="OrthoDB" id="1968497at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="125" mass="13595" checksum="7857458E30C21D34" modified="2004-07-05" version="1">MAEIEKVNLLDLDEEDYDTVLAPDIQFSGKIECKKPFMIKGHVEGFLVSTSDVTVDENSVVKANIRADRVVIKGAVEGNVLADTMVHVFSCGKLIGDVTAPEVVLESGCVFNGICTMTKDKQFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LH7</accession>
    <name>Q73LH7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MiaB-like tRNA modifying enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_1886</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972489.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679581.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1886"/>
    <dbReference type="EnsemblBacteria" id="AAS12400">
        <property type="protein sequence ID" value="AAS12400"/>
        <property type="gene ID" value="TDE_1886"/>
    </dbReference>
    <dbReference type="GeneID" id="2739115"/>
    <dbReference type="KEGG" id="tde:TDE_1886"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1787"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_1_0_12"/>
    <dbReference type="OMA" id="HFHIPLQ"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006467">
        <property type="entry name" value="MiaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01579">
        <property type="entry name" value="MiaB-like-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="178"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS12400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="468" mass="52756" checksum="EE53FD04CB2C2BC3" modified="2004-07-05" version="1">MSNFFSVRIETLGCRLNQVESEALAVRFAECGFDVFSKEAETSILPVKLCIVNTCTVTGKAEQKARRLIRLLLKEHEESVILVTGCYAELEADSIEKINKRIIAFSGKKKDELDGLPQFLKDSCLKNKDLKEDTVNLKKNLLIFRNEIYAKEDQQDKSFLLKETERRKSMFKLSSPVFVFHSRASLKIQDGCNNACAYCRIRLARGTSVSLPAEEAVRRIVQIEKNGAAEVVLSGVNLSQYRDETYGGFANLLAKLLENTKKIRLRISSMYPECVDDGILEIVANKRICPHFHLSIQSGSDKILKAMNRPYREADIRMAINNLRKAKDNPFIGCDIITGFPSETEEDFLQTFKMCEDLKIPGIHVFPFSARPGTKAFSMRPKVPEREAGRRASLLSELSGKNYQSYLASCNGKLFFGVIEKPQNNEDLRIVTENYLSLPLVVNKKAENYKGGEGLFVVIKDGNAYLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LJ7</accession>
    <name>Q73LJ7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, M16 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972469.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679557.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1865"/>
    <dbReference type="EnsemblBacteria" id="AAS12380">
        <property type="protein sequence ID" value="AAS12380"/>
        <property type="gene ID" value="TDE_1865"/>
    </dbReference>
    <dbReference type="GeneID" id="2740054"/>
    <dbReference type="KEGG" id="tde:TDE_1865"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1770"/>
    <dbReference type="eggNOG" id="COG1026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009165_1_0_12"/>
    <dbReference type="OMA" id="MTYPDKT"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M16C_associated" evidence="1">
        <location>
            <begin position="469"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1017" mass="114046" checksum="D5ADA1474CF3ACA4" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LK2</accession>
    <name>Q73LK2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972464.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669622.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1860"/>
    <dbReference type="EnsemblBacteria" id="AAS12375">
        <property type="protein sequence ID" value="AAS12375"/>
        <property type="gene ID" value="TDE_1860"/>
    </dbReference>
    <dbReference type="GeneID" id="2740049"/>
    <dbReference type="KEGG" id="tde:TDE_1860"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1765"/>
    <dbReference type="eggNOG" id="COG4709">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080365_2_0_12"/>
    <dbReference type="OMA" id="LISFEIC"/>
    <dbReference type="OrthoDB" id="1916098at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012963">
        <property type="entry name" value="DUF1700"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08006">
        <property type="entry name" value="DUF1700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="176" mass="19487" checksum="96881C748E864E65" modified="2004-07-05" version="1">MKRREFIEELEDRLRHLPYKDRKEAIKFYEEYFDEAGSENEQTVINELRSPAHIASKILSDYAIKEAEGARKSARGGLRALWFTILGIFAAPIAIPLAVILTVVIVLLCVGLCVASIALVFGGGILAVFAFGMLFVDFGTGILLIGAILIAIGFTRLLYLFVTAIIRKISQLVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LL1</accession>
    <name>Q73LL1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972455.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679548.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1851"/>
    <dbReference type="EnsemblBacteria" id="AAS12366">
        <property type="protein sequence ID" value="AAS12366"/>
        <property type="gene ID" value="TDE_1851"/>
    </dbReference>
    <dbReference type="GeneID" id="2740040"/>
    <dbReference type="KEGG" id="tde:TDE_1851"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1756"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036078_0_0_12"/>
    <dbReference type="OMA" id="FTIREVP"/>
    <dbReference type="OrthoDB" id="371311at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="399"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="506" mass="55768" checksum="D1AC519737F9BF0B" modified="2004-07-05" version="1">MNKTIFKMAVKNLFASKAKMIITLSLIGIGTFLVILGFGILNFSLQQTQEVCISDFSGDVLITGKPEKDTVMVQLLGVFQTVSVSMDTPKMPYLVPFEKVKSKVESLPDVKGLTPSVFASGMLKALDLPDSWEAEDKNRSFLPYAQILGIEPESYKNLFDTINIYEGEYPKTSNGKFALIPRDLKEKFEKYYDRPLNLGDEILVTAFAGKARQQKVIITGFFDYAHPDTAIDGIAYFDVDTTRILADMTMGARVAAAIPDSVDLSLSEKSEDELFADDSGADIIDTVQNSNSKIDYENLLGSTELRDRLNLADNEAWHHIVIKLKDSSKTQSVIKTLNDWFKEEGISARAVNWERGMAMYYSAIEGTRILFITMLAILSVVVLIVIMNTLVVAVMQRSSEIGTMRAIGAKKGFVRKIFFAESFFMSCVGVLIGLVLALIAAAVVNAFDIRVGDILAAMFGGKQIRVSISIGSAVWTMAAMLLAGLAANWYPVRLALKISPLEAINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LV6</accession>
    <name>Q73LV6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972360.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12271">
        <property type="protein sequence ID" value="AAS12271"/>
        <property type="gene ID" value="TDE_1756"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1756"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1679"/>
    <dbReference type="eggNOG" id="ENOG5031CZD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1420884_0_0_12"/>
    <dbReference type="OrthoDB" id="2118798at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="155" mass="17482" checksum="1FD5A456A946E687" modified="2004-07-05" version="1">MGLITTIIFIEILVGINSYYLDFVFIPIIVWVLGAFFLIYLVVCEHKTYSNVQEIIVHLSSTGRHEGLCDALLEGFIKFGAGMPPRGFYGSDIYLYQQSFLEFSNLDLTGESQDLIKLQKIVRKARIMPRILISLFIAFALQIVPVIVGVAMKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LV8</accession>
    <name>Q73LV8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Desulfoferrodoxin/neelaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1754</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the desulfoferrodoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972358.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679492.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1754"/>
    <dbReference type="EnsemblBacteria" id="AAS12269">
        <property type="protein sequence ID" value="AAS12269"/>
        <property type="gene ID" value="TDE_1754"/>
    </dbReference>
    <dbReference type="GeneID" id="2740599"/>
    <dbReference type="KEGG" id="tde:TDE_1754"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1677"/>
    <dbReference type="eggNOG" id="COG2033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118960_1_1_12"/>
    <dbReference type="OMA" id="EEKHYIQ"/>
    <dbReference type="OrthoDB" id="1496450at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002742">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036073">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01880">
        <property type="entry name" value="Desulfoferrodox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49367">
        <property type="entry name" value="SSF49367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00332">
        <property type="entry name" value="neela_ferrous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Desulfoferrodox" evidence="6">
        <location>
            <begin position="43"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="128" mass="13895" checksum="B3CED10C90C1285D" modified="2004-07-05" version="1">MSKEISFFLCKEKKGTIIGIDCCPDAEVSCCGEKLSAVKIGSVDAAKEKHVPVVEVNGNTVKVKVGSVAHPMTEEHHIAWVCLKTEKGLQFKELAVTGAPEVEFSLTSDDKVIEAYEFCNLHGVWSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M25</accession>
    <name>Q73M25_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">aroA</name>
        <name evidence="10" type="ordered locus">TDE_1686</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972290.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679391.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1686"/>
    <dbReference type="EnsemblBacteria" id="AAS12201">
        <property type="protein sequence ID" value="AAS12201"/>
        <property type="gene ID" value="TDE_1686"/>
    </dbReference>
    <dbReference type="GeneID" id="2740141"/>
    <dbReference type="KEGG" id="tde:TDE_1686"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1613"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_0_12"/>
    <dbReference type="OMA" id="YEDHRMA"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="101"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS12201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="449" mass="49177" checksum="5D64A9529468AB1E" modified="2004-07-05" version="1">MILKIKKSKPVSPMPIEVPPSKSHSMRALVLATFAEGPSQIKNLLMSGDTKTAVSVFESLGVKFKIEQKNISSADIIVFPPKEGLKKRIEKQKQIKIDAGNSGTLFYFLGSILSLMSSDFILTGDSSILKRPAKPLIEIYEELGLKYEFLDGFEKAPIRVLPGSSSIKNLKGKTLCLEGDFSQVVSGLLLGAGLLDFPLQINLKRAGELPYLKMTLHWLKTCGIKFDVSDDFKTFKIIESQKILGFSAGIPADWSSAAFPIALALITASTISIKNIDINDVQGDARIVKVLKEMNADIRFEEKSQTLKIFPSSLKGGTFDCSDIPDAVPALSAIACFAKGETILKNIEICRYKECDRLSVISSELKKLGADITEGRDVLHIIGNAGKNLSPASVDSHKDHRIAMMLTIIGFGIDDKDGTVFTLKNAECFDISYPSFLEDLKRMGFNISQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M28</accession>
    <name>VATA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V-type ATP synthase alpha chain</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">V-ATPase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpA</name>
        <name type="ordered locus">TDE_1683</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972287.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669362.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M28"/>
    <dbReference type="SMR" id="Q73M28"/>
    <dbReference type="STRING" id="243275.TDE_1683"/>
    <dbReference type="PRIDE" id="Q73M28"/>
    <dbReference type="EnsemblBacteria" id="AAS12198">
        <property type="protein sequence ID" value="AAS12198"/>
        <property type="gene ID" value="TDE_1683"/>
    </dbReference>
    <dbReference type="GeneID" id="2740138"/>
    <dbReference type="KEGG" id="tde:TDE_1683"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1610"/>
    <dbReference type="eggNOG" id="COG1155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008162_1_1_12"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="OrthoDB" id="875807at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000059361" description="V-type ATP synthase alpha chain">
        <location>
            <begin position="1"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="239"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <sequence length="589" mass="65263" checksum="D86E649B38F36992" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M29</accession>
    <name>VATB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpB</name>
        <name type="ordered locus">TDE_1682</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972286.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669361.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M29"/>
    <dbReference type="SMR" id="Q73M29"/>
    <dbReference type="STRING" id="243275.TDE_1682"/>
    <dbReference type="EnsemblBacteria" id="AAS12197">
        <property type="protein sequence ID" value="AAS12197"/>
        <property type="gene ID" value="TDE_1682"/>
    </dbReference>
    <dbReference type="GeneID" id="2740137"/>
    <dbReference type="KEGG" id="tde:TDE_1682"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1609"/>
    <dbReference type="eggNOG" id="COG1156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022916_2_0_12"/>
    <dbReference type="OMA" id="GFKIKPR"/>
    <dbReference type="OrthoDB" id="875807at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000059399" description="V-type ATP synthase beta chain">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <sequence length="431" mass="47341" checksum="F0DF19DEAB822870" modified="2004-07-05" version="1">MKKVYSKIESINGSVITVKADGVSYGELAEVQTRFGASLAEVNKLEGDLVSLQVFAGGRGVSTGDEVRFLGKEMQVSYSEDLLGRIFNGSGDPRDSGPALKDNMIPIGGPSVNPSKRILANRMIRTGIPMIDVFNTLVVSQKLPIFSSSGEPYNELLARIAMQAEVDVIILGGMGLKYDDYLYFKDTLEEAGALSRTAMFVHTAADPTVECLMIPDMCLAVAEKFAIAGKNVLVLLTDMTNFADAMKEIAIIQEQVPSNRGYPGDLYSQLAARYEKAVDFADAGSVTVLAVTTMPGDDVTHPVPDNTGYITEGQFYLKNGRIEPFGSLSRLKQNVNGKTRDDHRALMDNMIKLYASYKDTLEKKSMGFMMSEWDEKLLKYGAKFESGMMDLSVNIPLEDALNLGWKILAECFTREETGIKSELVNKYWPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ME1</accession>
    <name>Q73ME1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972173.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671162.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1567"/>
    <dbReference type="EnsemblBacteria" id="AAS12084">
        <property type="protein sequence ID" value="AAS12084"/>
        <property type="gene ID" value="TDE_1567"/>
    </dbReference>
    <dbReference type="GeneID" id="2739317"/>
    <dbReference type="KEGG" id="tde:TDE_1567"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1501"/>
    <dbReference type="HOGENOM" id="CLU_1411653_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="199" mass="22815" checksum="71165AFDC8B0F724" modified="2004-07-05" version="1">MKIIIGIFLLVAVCVIGIYSFINGGLFADILYPKTSFGFYCLDAKPPSAVDQRLAFGDKYPQAFNLYFSPPGNILTLRVVKTAIQFDLFVKKPYTILKINEMRVLFNDGKTIKTLCKNKVYTFKDSYYETLNGWYFLREFADPLATIKLGNVFMDKKAGDEFNCVIEIQYSLDNEPVQIQKLNYRVVAVKGKFQDIYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MH5</accession>
    <name>Q73MH5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972139.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679186.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1533"/>
    <dbReference type="EnsemblBacteria" id="AAS12050">
        <property type="protein sequence ID" value="AAS12050"/>
        <property type="gene ID" value="TDE_1533"/>
    </dbReference>
    <dbReference type="GeneID" id="2740895"/>
    <dbReference type="KEGG" id="tde:TDE_1533"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1470"/>
    <dbReference type="eggNOG" id="ENOG5033X70">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041913_0_0_12"/>
    <dbReference type="OMA" id="GLDWTRN"/>
    <dbReference type="OrthoDB" id="1036884at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="487" mass="55377" checksum="1CDC3CCB632705D6" modified="2004-07-05" version="1">MNMGSFNINFKKYIFILFFSLSFFSVYSDDDIKESYDSEFLKVDDGLIPLVPLDRMPDSALVRRDIAKSWLLAAPEEIASRHLHIDADSAGNLFKIRSVYLKEKKLLAVVISPIDTEFSNLEKVPQGTWILYRNYETGAPECIKIYPRENPELYLSIRPSSSKDKSLISICLFNTYVRKDISVGIPFENLYYLPLLKLRDITKDMLPWDIFNPPIFYNGVEAASDTIRDRLKTLVYIQDGAFDEFGEPIHLTDGRPQTEDDIVKAIRPDQRLKDVKGGVNCSGFAKWIVDGMIRPIAGQGIFIKSLKTETDVPDTYFTKPYKERELYFGLEWIRNLAAAALSLNVKRTVKPIGSGLDVTVEPFALVPPIKQKNVKEDFASFKGYEKTAGYQTSYLQALLYYLAISEPGHFYLGAVSRTVSPEKGSPPLRQYHHIAAFFPYFDVFGNFHIDVYESGKETSIEQFMSLNSNAFTALVRIRAPQPGVFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MI1</accession>
    <name>Q73MI1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972133.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679173.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1527"/>
    <dbReference type="EnsemblBacteria" id="AAS12044">
        <property type="protein sequence ID" value="AAS12044"/>
        <property type="gene ID" value="TDE_1527"/>
    </dbReference>
    <dbReference type="GeneID" id="2739733"/>
    <dbReference type="KEGG" id="tde:TDE_1527"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1464"/>
    <dbReference type="HOGENOM" id="CLU_918093_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="303" mass="35580" checksum="9F3116E353CFB0E0" modified="2004-07-05" version="1">MREKKLKKMIIMIIKWSILLTFILMPAYSLFKYANDLVEFEGGVNKQLDGKIINKSEVTSILSDIKNRYLGLAISKIDTKLSDNIPLEARKYLLLFSKYYKYKNRTLFDEAANVVTDIAGYIPKIGDYFERDILKPEEYDNPEYFFEHLIDMTSYLESINLSKSDIYAFSEIIPYYCISKHELYNIKTAKLCDLYFKNITEPNGSVLSKEGAIIACIQIRSLYETRNSNEAEWKSLQDHIEKLRDIDFQNYLGENGRYPLQAEYLKNFYDHLSNLRNSGKLTKALGGNFWKKYRFDETIPELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MI4</accession>
    <name>Q73MI4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972130.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12041">
        <property type="protein sequence ID" value="AAS12041"/>
        <property type="gene ID" value="TDE_1524"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1524"/>
    <dbReference type="HOGENOM" id="CLU_3405976_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3562" checksum="961D5FF291376089" modified="2004-07-05" version="1">MFFMNFIKNDLNKVMCEFTPPPPPDKFLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MM3</accession>
    <name>Q73MM3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972091.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679152.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1485"/>
    <dbReference type="EnsemblBacteria" id="AAS12002">
        <property type="protein sequence ID" value="AAS12002"/>
        <property type="gene ID" value="TDE_1485"/>
    </dbReference>
    <dbReference type="GeneID" id="2739886"/>
    <dbReference type="KEGG" id="tde:TDE_1485"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1424"/>
    <dbReference type="eggNOG" id="ENOG5031CIR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1354106_0_0_12"/>
    <dbReference type="OMA" id="CLAIGHA"/>
    <dbReference type="OrthoDB" id="1639179at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="201" mass="21970" checksum="6C6364EDD45C8DBA" modified="2004-07-05" version="1">MNDKEIKERLALISALTEDVQEGLEDMIVPFLLYGITIPIGTFISYFLAKSGFSLFIPLLWLFIMTACQLFLALFMKRKQKIKIKRVTDRILAALWGSIGAGLILGMILGILGKLDFNTNFFNIGLCLAIGHAATAAMVQKKLRLFLCIEALCWAGCGVVCLFAAQYTAPLIIGVATFILLGLPAAVAIVIGKRKKTVKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MP5</accession>
    <name>Q73MP5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972069.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679119.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1463"/>
    <dbReference type="EnsemblBacteria" id="AAS11980">
        <property type="protein sequence ID" value="AAS11980"/>
        <property type="gene ID" value="TDE_1463"/>
    </dbReference>
    <dbReference type="GeneID" id="2741578"/>
    <dbReference type="KEGG" id="tde:TDE_1463"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1404"/>
    <dbReference type="eggNOG" id="ENOG502ZI1Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_979834_0_0_12"/>
    <dbReference type="OMA" id="NDRRNEN"/>
    <dbReference type="OrthoDB" id="1677534at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284960" evidence="1">
        <location>
            <begin position="25"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="288" mass="32358" checksum="1B18334D70D41E48" modified="2004-07-05" version="1">MKIKKCYGFLIFLLLMLSIPVVRAGSMLYASPTVGVFKLESKNITEQTTATISNAIFSFVKELKKYDIVDMRSTPVTETDAQQRFDYVFAGKITGLENGIQLELMLKNSSDKITRRISKIYQSVNLILLDSRVLVSDIFDKSVNLSVTYNPEDSDSKENSEVEEVKNIDILSGSWQGEEGLERVELMRGGRGIALLSSGITILLQIRIHEGYLTINQSGKPMPRQFINLPDEIAKKAAEMGKTPSWKFLVSADNKILVGEKTDIEIVYHGNTLVSVNEVIKKVRWIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MS1</accession>
    <name>Q73MS1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1436</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972042.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679058.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1436"/>
    <dbReference type="EnsemblBacteria" id="AAS11953">
        <property type="protein sequence ID" value="AAS11953"/>
        <property type="gene ID" value="TDE_1436"/>
    </dbReference>
    <dbReference type="GeneID" id="2741399"/>
    <dbReference type="KEGG" id="tde:TDE_1436"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1377"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013421_0_0_12"/>
    <dbReference type="OMA" id="NNTTHEP"/>
    <dbReference type="OrthoDB" id="369860at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="916" mass="104835" checksum="9C998F0873002D41" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MW5</accession>
    <name>Q73MW5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NQR2/RnfD/RnfE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_1391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971997.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678975.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1391"/>
    <dbReference type="EnsemblBacteria" id="AAS11908">
        <property type="protein sequence ID" value="AAS11908"/>
        <property type="gene ID" value="TDE_1391"/>
    </dbReference>
    <dbReference type="GeneID" id="2741258"/>
    <dbReference type="KEGG" id="tde:TDE_1391"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1333"/>
    <dbReference type="eggNOG" id="COG4658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069371_0_0_12"/>
    <dbReference type="OMA" id="PWYAVAG"/>
    <dbReference type="OrthoDB" id="1654433at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578">
        <property type="entry name" value="PTHR30578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="344" mass="37352" checksum="0CDC81B602D382F8" modified="2004-07-05" version="1">MKSYSNLSLTAAPFVYTRLPIFKINIVVLSLLGIQILILALSADLYALLNIVIAVMGVLFVENLLRYLASSKFGLSLEMIISGLLIGFFMPTGIGFVFVFILSAFSVFIVKTVFGGTGRNWLNPVAFAVCAAYISRPEAFPPLISDFSLLAEKGSFFAVMEANGLLKLKTDFTITSALNSILLHGVGVTLPEGYISLFLNSTSSIPAFRYNIVTLVSSIILFSIRAVDYILPAFFLATYAVLVWIFGMAPVSNIYFTGDILSAVLTGGILFAAFFVMTEPASSPKTKYGKAMIGFFTGVFAFFICAHGASPAGIFFAIILGNIISPLIERLEIKIQAKKRSLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MZ9</accession>
    <name>Q73MZ9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Aldose 1-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">galM</name>
        <name evidence="11" type="ordered locus">TDE_1357</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>alpha-D-glucose = beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:10264"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="5.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.3" evidence="4 7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971963.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668712.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1357"/>
    <dbReference type="EnsemblBacteria" id="AAS11874">
        <property type="protein sequence ID" value="AAS11874"/>
        <property type="gene ID" value="TDE_1357"/>
    </dbReference>
    <dbReference type="GeneID" id="2739458"/>
    <dbReference type="KEGG" id="tde:TDE_1357"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1305"/>
    <dbReference type="eggNOG" id="COG2017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031753_4_2_12"/>
    <dbReference type="OMA" id="ATWLSCK"/>
    <dbReference type="OrthoDB" id="1512477at2"/>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019318">
        <property type="term" value="P:hexose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015443">
        <property type="entry name" value="Aldose_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005096">
        <property type="entry name" value="GALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005096-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="351" mass="39140" checksum="C9AB30C640DEC1B4" modified="2004-07-05" version="1">MKITTTEFGTFSNGNKALLFTIFNGKMMLCCTNYGCCITGILLPSKNGGFDDVVLGYSSFIGYINNFPHFGSFIGRYAGRISNAEFTLGNQQYLLTPNDGGKHCLHGGYPYCDKMLYEAKTFKNRQEAGVVFSRTSPDGEQGFPGNLKIQVSYSLTPDNEIIIRYKAVSDKTTPVNFTNHSYFNLNPAGMQSNGSYVSVLNHEVQIFAEQYLEINQELIPTGKFLNVENTGYDFRKPKLLSEGVQEIGGGFDNSWVIKKEVSDHKTLAAIVKEPVTKRTLTVYSAQPALIMYTGGFLNNELGKNGDVYNKFAGLCLESQAFPDSLHQPHFPNTVIKPGEVYERETLWHFAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N17</accession>
    <name>SP5G_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative septation protein SpoVG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">spoVG</name>
        <name type="ordered locus">TDE_1339</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in septation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SpoVG family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971945.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678893.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73N17"/>
    <dbReference type="SMR" id="Q73N17"/>
    <dbReference type="STRING" id="243275.TDE_1339"/>
    <dbReference type="EnsemblBacteria" id="AAS11856">
        <property type="protein sequence ID" value="AAS11856"/>
        <property type="gene ID" value="TDE_1339"/>
    </dbReference>
    <dbReference type="GeneID" id="2741073"/>
    <dbReference type="KEGG" id="tde:TDE_1339"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1287"/>
    <dbReference type="eggNOG" id="COG2088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103669_2_1_12"/>
    <dbReference type="OMA" id="KDVAHPI"/>
    <dbReference type="OrthoDB" id="1871825at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00819">
        <property type="entry name" value="SpoVG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007170">
        <property type="entry name" value="SpoVG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036751">
        <property type="entry name" value="SpoVG_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38429">
        <property type="entry name" value="PTHR38429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04026">
        <property type="entry name" value="SpoVG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160537">
        <property type="entry name" value="SSF160537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_0000157217" description="Putative septation protein SpoVG">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00819"/>
        </source>
    </evidence>
    <sequence length="93" mass="10498" checksum="B73697B41A0F6791" modified="2004-07-05" version="1">MEITEVRVQRVSPGNSLKAYANITFDDCFVLHNVRVIEGNDGLYIGMPSRKLSNGEFKNIAHPITAEFREKMTKAVLEVYEKTPIMPGQEAEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N18</accession>
    <name>ISPE_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="1">CMK</shortName>
            <ecNumber evidence="1">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispE</name>
        <name type="ordered locus">TDE_1338</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971944.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678892.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73N18"/>
    <dbReference type="SMR" id="Q73N18"/>
    <dbReference type="STRING" id="243275.TDE_1338"/>
    <dbReference type="EnsemblBacteria" id="AAS11855">
        <property type="protein sequence ID" value="AAS11855"/>
        <property type="gene ID" value="TDE_1338"/>
    </dbReference>
    <dbReference type="GeneID" id="2741072"/>
    <dbReference type="KEGG" id="tde:TDE_1338"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1286"/>
    <dbReference type="eggNOG" id="COG1947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053057_2_0_12"/>
    <dbReference type="OMA" id="RWPSPAK"/>
    <dbReference type="OrthoDB" id="1938933at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000189281" description="4-diphosphocytidyl-2-C-methyl-D-erythritol kinase">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <sequence length="284" mass="31226" checksum="24B74277A7ED8C07" modified="2004-07-05" version="1">MIKSAISLKAHAKINLHLEVLGKRSDGFHDIVSVFAPISLADELLMQRKPDKKECKVLSPLAELPAENTITRAYEEFKNFAGISEGISVRILKRIPEGAGLGGGSSDAASVLRGLNDMFSTGLAEEDLRAIALKIGSDVPFFLGNEAAVVRGRGETIKRVSVFSDYFGILIYPEIKSATPRAYSLLGRKESEILNPAFNPELFCGKDCREWPFFNSFEDVLFTEYPAIKKAKQDLLTNGADFALMSGAGSSVFGLFKNEKTVKNAYSKLLAEYGRCFFFLLLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N70</accession>
    <name>Q73N70_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">TDE_1285</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliG family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971892.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678791.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1285"/>
    <dbReference type="EnsemblBacteria" id="AAS11803">
        <property type="protein sequence ID" value="AAS11803"/>
        <property type="gene ID" value="TDE_1285"/>
    </dbReference>
    <dbReference type="GeneID" id="2741039"/>
    <dbReference type="KEGG" id="tde:TDE_1285"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1235"/>
    <dbReference type="eggNOG" id="COG1536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047835_1_0_12"/>
    <dbReference type="OMA" id="YRKNEEF"/>
    <dbReference type="OrthoDB" id="847822at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000090">
        <property type="entry name" value="Flg_Motor_Flig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023087">
        <property type="entry name" value="Flg_Motor_Flig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011002">
        <property type="entry name" value="FliG_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032779">
        <property type="entry name" value="FliG_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028263">
        <property type="entry name" value="FliG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30534">
        <property type="entry name" value="PTHR30534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01706">
        <property type="entry name" value="FliG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14841">
        <property type="entry name" value="FliG_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14842">
        <property type="entry name" value="FliG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00954">
        <property type="entry name" value="FLGMOTORFLIG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48029">
        <property type="entry name" value="SSF48029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliG_N" evidence="12">
        <location>
            <begin position="28"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_M" evidence="11">
        <location>
            <begin position="137"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_C" evidence="10">
        <location>
            <begin position="239"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS11803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="355" mass="40014" checksum="2B7F2DB248AB3E09" modified="2004-07-05" version="1">MSDIESQMLKNGLIKVPVDEKSAGKESPYKRVAKFLFIIGAEQAADVLRQLTKEQIDKVVAELVTVQSIDKKEAYNILNEFNDIYNKNKNLLGGVDTAKTILTEAFGEARAEEILETAVPPKMPKPFEYLEGMDKDRLSRILQGELPATKAIVLSQLEPKQAAAYISSIEDEDEKKDIILRLAKLKKIDAEVLTQVSEALKKKLADVNLNRTSSVDGVSVLADILRKLDYETGSSILDSLDLEDENLTETIKRKLVTLDDVINMNPKHIQYLISPMTDKELALLIHNQSEEFRKVILANMSKSRAALVLDEEQYMGPVLKRDLNNTVDHFLARVKNEAERGRVIIVKDEDDKFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NB0</accession>
    <name>Q73NB0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971852.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678737.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1245"/>
    <dbReference type="EnsemblBacteria" id="AAS11763">
        <property type="protein sequence ID" value="AAS11763"/>
        <property type="gene ID" value="TDE_1245"/>
    </dbReference>
    <dbReference type="GeneID" id="2741421"/>
    <dbReference type="KEGG" id="tde:TDE_1245"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1197"/>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_949770_0_0_12"/>
    <dbReference type="OMA" id="GIPYYYA"/>
    <dbReference type="OrthoDB" id="1854984at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285859" evidence="1">
        <location>
            <begin position="24"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="329" mass="37851" checksum="0FB8E13869DCC4B5" modified="2004-07-05" version="1">MKKGFIIFLFVVSFCFAEQAAFAEEGLIGENELSQILPDVKPDKTGSEKIEFAENPQELQKNEDFAFLSFSILTRERSVMISWKAKPEGRNLILYRSTTGFSSISSLAEAVPIANITDDGLPFFDYPIPGIPYYYAIAEENEIASGKIQFINGINTINSPVEVFASPEEQEKKSIALQNRPIPLPFLNPEKQIKKRTEFFSSQTETLINALTAEKRDFREFIISSQRLEPYVFPDDKRTPDGGESMELQRILNDYFYTKNWQKCNVELTNFLRIRRTSRVSARTHFYIGQTLFFQNLYDKALLEFLTAQDLYPSQAKEWAHYCLVELAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NB1</accession>
    <name>Q73NB1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971851.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678736.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1244"/>
    <dbReference type="EnsemblBacteria" id="AAS11762">
        <property type="protein sequence ID" value="AAS11762"/>
        <property type="gene ID" value="TDE_1244"/>
    </dbReference>
    <dbReference type="GeneID" id="2741420"/>
    <dbReference type="KEGG" id="tde:TDE_1244"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1196"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_412143_0_0_12"/>
    <dbReference type="OMA" id="KHYENEG"/>
    <dbReference type="OrthoDB" id="373006at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004286003" evidence="2">
        <location>
            <begin position="23"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="658" mass="75961" checksum="3C00CCA94503A4C2" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NB3</accession>
    <name>YBEY_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybeY</name>
        <name type="ordered locus">TDE_1242</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971849.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668517.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NB3"/>
    <dbReference type="SMR" id="Q73NB3"/>
    <dbReference type="STRING" id="243275.TDE_1242"/>
    <dbReference type="EnsemblBacteria" id="AAS11760">
        <property type="protein sequence ID" value="AAS11760"/>
        <property type="gene ID" value="TDE_1242"/>
    </dbReference>
    <dbReference type="GeneID" id="2741184"/>
    <dbReference type="KEGG" id="tde:TDE_1242"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1194"/>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106710_3_3_12"/>
    <dbReference type="OMA" id="RMRIHPL"/>
    <dbReference type="OrthoDB" id="1830156at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000102557" description="Endoribonuclease YbeY">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <sequence length="155" mass="17934" checksum="04E720A0F2EAA0A2" modified="2004-07-05" version="1">MSNSISVSFNDEPPGSIDPVRVENFISEVLKDLNLKNWDISLLFCDDAFIQNLNKQYRDIDSPTDVLSFEQGDEYFDEAGETRFMAGDIVISLDSLSFNAEEFNVDINEELKRLIVHGILHLNGMDHSDNSPEQEMLKFQEELLMQYKNMEIYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NH1</accession>
    <name>Q73NH1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971789.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682429.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1181"/>
    <dbReference type="EnsemblBacteria" id="AAS11700">
        <property type="protein sequence ID" value="AAS11700"/>
        <property type="gene ID" value="TDE_1181"/>
    </dbReference>
    <dbReference type="GeneID" id="2740078"/>
    <dbReference type="KEGG" id="tde:TDE_1181"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1139"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1440474_0_0_12"/>
    <dbReference type="OrthoDB" id="1213908at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_2" evidence="1">
        <location>
            <begin position="65"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="188" mass="21459" checksum="712875A6B5CE6963" modified="2004-07-05" version="1">MKKSVRFLSKKSSEYIGEVLLFRKKLSALVNIKELIDSNQEKNTEKFSQNKFFDFAEMAQINIQEILTFRKQTLLAAVNSSCKKGPKNVLDLGGGAGVMLGAIAKQYPCASYTLFERPVVAKIAYDYIKQISLKNTVKIIEGDFLKDDIRNDYDLIIASGIFPFRNLIKKEDCEKDKKIMLTVFYTLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NP8</accession>
    <name>TRUB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="1">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truB</name>
        <name type="ordered locus">TDE_1104</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971712.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682411.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NP8"/>
    <dbReference type="SMR" id="Q73NP8"/>
    <dbReference type="STRING" id="243275.TDE_1104"/>
    <dbReference type="EnsemblBacteria" id="AAS11593">
        <property type="protein sequence ID" value="AAS11593"/>
        <property type="gene ID" value="TDE_1104"/>
    </dbReference>
    <dbReference type="GeneID" id="2740234"/>
    <dbReference type="KEGG" id="tde:TDE_1104"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1063"/>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_0_0_12"/>
    <dbReference type="OMA" id="VELTHAE"/>
    <dbReference type="OrthoDB" id="1166299at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000121933" description="tRNA pseudouridine synthase B">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <sequence length="357" mass="40131" checksum="66AB98094F6466CA" modified="2004-07-05" version="1">MELNKNLIIPFAKQAGLTSFASMSAVKKALSTKKVGHTGTLDLFADGLLVLLTGQLTRLADIISAEKKTYEAWVEFGTETDTLDPEGEPVLTAPLPSYKNLTESIPSFLGKILQRPPEFSAIKINGKRASDRIRSGEKIKIAEREIEIFKIELKGIITDSGLEFTEKDFTNINAELKIRYAHIVVECSKGTYIRSLVRDLARKASSCAYVRALRRTAVGNFKLEDAAGFDLLNNFSAAPENLFLKEKKILDAAAGKKFYKQKEIDFLEIMAKSIIFSPKTAENLKLPYLFLDRKYLNDFYNGKKIKFNWFLNTDEVLENITGLDLENKKTCVFCGDLWIGIIGLNKNCPKYETVIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NZ5</accession>
    <name>Q73NZ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971614.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1005"/>
    <dbReference type="EnsemblBacteria" id="AAS11495">
        <property type="protein sequence ID" value="AAS11495"/>
        <property type="gene ID" value="TDE_1005"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1005"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.965"/>
    <dbReference type="HOGENOM" id="CLU_2774745_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="69" mass="7983" checksum="971B5F09AB62A806" modified="2004-07-05" version="1">MLSSFIGELKKDLRKKLEFFYSCGGSFISVILQKFYISFSKKKFYNAENHIRAMINSSAEIQPHCLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P24</accession>
    <name>Q73P24_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971585.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682287.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0975"/>
    <dbReference type="EnsemblBacteria" id="AAS11466">
        <property type="protein sequence ID" value="AAS11466"/>
        <property type="gene ID" value="TDE_0975"/>
    </dbReference>
    <dbReference type="GeneID" id="2740547"/>
    <dbReference type="KEGG" id="tde:TDE_0975"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.938"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068216_0_1_12"/>
    <dbReference type="OMA" id="ILEKCHA"/>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="1">
        <location>
            <begin position="67"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="292" mass="33446" checksum="73C73FB1DC950F0D" modified="2004-07-05" version="1">MSTSNRKYKDSVFVDLFSEDEKAKENFLSLYNALHGTNLPLSSPVENIRLDNVMYMNIINDVSCLVDGKIIVLAEHQSTINENMPLRFLEYIARLYEKLQAPTDRYLRKLSKIPTPEFYVFYNGKEDYPETTVLKLSDAFITKPEQMPLELTVRVLNINTDKANKVLAACKPLEEYSLFVEEVRKQTQLDSEKGFTNAVKICIEKGILKEYLQRKSREVINMLVAEYDYDADIAVQRAEERQIAFAEGIEQGIADGVYKKALETAKLMRYENLGIDLISKVTGLSVEEIKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P29</accession>
    <name>Q73P29_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971580.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0970"/>
    <dbReference type="EnsemblBacteria" id="AAS11461">
        <property type="protein sequence ID" value="AAS11461"/>
        <property type="gene ID" value="TDE_0970"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0970"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.934"/>
    <dbReference type="HOGENOM" id="CLU_2157255_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="111" mass="12934" checksum="56AA7F13DC0D7EE2" modified="2004-07-05" version="1">MGVSSTLGAHCGLFRSVFNLTARNSSYCIILKILVWFWKRGVYMKKYFLYVKKGLLWSLSFIIILSLIHYLRVQKFYGYDWYLLAIPIVLLIGGPLYAFAVEKINNKKNGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P36</accession>
    <name>DPO4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase IV</fullName>
            <shortName evidence="1">Pol IV</shortName>
            <ecNumber evidence="1">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dinB</name>
        <name type="ordered locus">TDE_0963</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971573.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956849.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73P36"/>
    <dbReference type="SMR" id="Q73P36"/>
    <dbReference type="STRING" id="243275.TDE_0963"/>
    <dbReference type="EnsemblBacteria" id="AAS11454">
        <property type="protein sequence ID" value="AAS11454"/>
        <property type="gene ID" value="TDE_0963"/>
    </dbReference>
    <dbReference type="GeneID" id="2740771"/>
    <dbReference type="KEGG" id="tde:TDE_0963"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.927"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_1_2_12"/>
    <dbReference type="OMA" id="KVRRYDF"/>
    <dbReference type="OrthoDB" id="442163at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0515">Mutator protein</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000213591" description="DNA polymerase IV">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <sequence length="395" mass="44581" checksum="75A9690381DBD097" modified="2004-07-05" version="1">MATEKVFFHVDIDAFFASVEQLDNPEYMGKPVIVGGQSERGVVSTCSYEARKFGVHSAMPILQARKLCPSGIFLRGRMDRYHEKSKEVMSIFKDFTPEIKQISVDEAFLNMTGMEKIFGTPKNSALLLKKTIKEETGLTVSVGCAQNKYIAKIASGRSKPDGLFIVKAGEEIDFMKSLPLKDVWGVGGKTRERLIAAGLTSVPQIFNSSEHLLQSILGNASGSFLFQAVRGELYDVFSDDVKSHSISTERTFEHDLFSHAEIDDVMFYLASELMYRIFDEKVKGKTVSVKIRYNDFTTVSVQSTGAVVNDTQDLFERARELFYKKFDNKTPIRLLGLCIMNIESDIPEAQTELFYSEKNVKKRKIEETMYTLTKKEGKNILKPARLLKKDKDGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P52</accession>
    <name>Q73P52_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation elongation factor G, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971557.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682245.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0947"/>
    <dbReference type="EnsemblBacteria" id="AAS11438">
        <property type="protein sequence ID" value="AAS11438"/>
        <property type="gene ID" value="TDE_0947"/>
    </dbReference>
    <dbReference type="GeneID" id="2740980"/>
    <dbReference type="KEGG" id="tde:TDE_0947"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.911"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_12"/>
    <dbReference type="OMA" id="DRGHEDH"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="6"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="692" mass="75741" checksum="B9675032D64DB6E5" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P55</accession>
    <name>Q73P55_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4469 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971554.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670345.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0944"/>
    <dbReference type="EnsemblBacteria" id="AAS11435">
        <property type="protein sequence ID" value="AAS11435"/>
        <property type="gene ID" value="TDE_0944"/>
    </dbReference>
    <dbReference type="GeneID" id="2740977"/>
    <dbReference type="KEGG" id="tde:TDE_0944"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.909"/>
    <dbReference type="eggNOG" id="ENOG502ZCIQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092785_0_0_12"/>
    <dbReference type="OMA" id="MITKERS"/>
    <dbReference type="OrthoDB" id="1533507at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd12843">
        <property type="entry name" value="Bvu_2165_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027824">
        <property type="entry name" value="DUF4469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14734">
        <property type="entry name" value="DUF4469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4469" evidence="1">
        <location>
            <begin position="129"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="236" mass="26277" checksum="ADBAA8044E2C1716" modified="2004-07-05" version="1">MHLRPNTLTKDNDRDCIADVHAHAATQRNEDIAEMITKERSEFSKETIINILNMRDKAVKDLIQEGLSFMDGLVQISPRVSGVWETENSSYDEKIHKRTVDLIPTADLRTTLDAIGVKVLGAKEETARITEITYTATGLKDGSLTIGDDIIIEGSKIKVDETDPAQGVFFKAADGTEYKTNRRLSVNNPSQIIARVPKEVPEGKVEVMVRTKFSTGNKTLLQIREIVYGYPCKAKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-21" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P93</accession>
    <name>Y906_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>Putative ABC transporter ATP-binding protein TDE_0906</fullName>
            <ecNumber>7.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_0906</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971516.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682198.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73P93"/>
    <dbReference type="SMR" id="Q73P93"/>
    <dbReference type="STRING" id="243275.TDE_0906"/>
    <dbReference type="EnsemblBacteria" id="AAS11397">
        <property type="protein sequence ID" value="AAS11397"/>
        <property type="gene ID" value="TDE_0906"/>
    </dbReference>
    <dbReference type="GeneID" id="2739946"/>
    <dbReference type="KEGG" id="tde:TDE_0906"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.877"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_12"/>
    <dbReference type="OMA" id="RVCVMQR"/>
    <dbReference type="OrthoDB" id="870493at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092122" description="Putative ABC transporter ATP-binding protein TDE_0906">
        <location>
            <begin position="1"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="2">
        <location>
            <begin position="267"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="300"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="491" mass="54974" checksum="27B5051F98704479" modified="2004-07-05" version="1">MINLNDVSYKYNDTAAQAIQHISLSVKKGELVVITGKSGCGKTTLFRCVNGLCPRFYEGEITGSLTLNGKVLSSMRICDISNIAASVFQNPESQFFTTDVLSDLVYPCENCGIEKEEIQERLHRVTKLLSLEPLLNRKLSELSGGEKQKIAIASVLMLDTRVVLMDEPSSNLDYQSVELLTQILAQLKSKGYTLLIIEHRLHYLAELCDRLIVMENGSIVREYEKDLLCTIGNDEFHKQGLRGLHLFQNNSNTLITPQRQHTDKRLLTLHDIHFGYRKNTEVLKGIHLSIYPGDKIALIGKNGCGKTTLGKILCGLKKEQSGTVLLDGRSFPARVRSKTAGYVMQNVDFQLFGCSVYDDLLLGNEALPDKENRIQTVLEKLSLSALQEQHPTTLSMGQKQRLVVAASFLQNKRLTIFDEPTSGLDYGSMQNVCALIDSITGKTNASVIITHDYEFILNTCNRAVLLEDGQIKEDFQLNGSMQLEYIFKERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PF4</accession>
    <name>Q73PF4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971455.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670138.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0845"/>
    <dbReference type="EnsemblBacteria" id="AAS11336">
        <property type="protein sequence ID" value="AAS11336"/>
        <property type="gene ID" value="TDE_0845"/>
    </dbReference>
    <dbReference type="GeneID" id="2739622"/>
    <dbReference type="KEGG" id="tde:TDE_0845"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.814"/>
    <dbReference type="eggNOG" id="COG2013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040551_0_1_12"/>
    <dbReference type="OMA" id="ICQKDAF"/>
    <dbReference type="OrthoDB" id="1063432at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="SSF51219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00266">
        <property type="entry name" value="TIGR00266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="224" mass="23674" checksum="6F7ED39CF728273C" modified="2004-07-05" version="1">MEYKIIGDAFPAVVCKLRAGEKMITQSGGMAWMSSGISMETSAGGVGKALGRMFSGESLFLNKYTANTDGEISFASRFPGAIKAFEITSGSSLIAQKTAFLASTEGVDLSIYFQKKLGAGFFGGEGFIMQKLSGNGTVFLEIDGSAVEYTLGAGETMLLDTGYLAAMEETCKMEVEMIKGVKNILFGGEGLFNTKVTGPGKIIIQTMPIHAVAQSLIPFLPHGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-08" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PH1</accession>
    <name>MNMG_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmG</name>
        <name evidence="1" type="synonym">gidA</name>
        <name type="ordered locus">TDE_0828</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971438.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682089.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PH1"/>
    <dbReference type="SMR" id="Q73PH1"/>
    <dbReference type="STRING" id="243275.TDE_0828"/>
    <dbReference type="EnsemblBacteria" id="AAS11319">
        <property type="protein sequence ID" value="AAS11319"/>
        <property type="gene ID" value="TDE_0828"/>
    </dbReference>
    <dbReference type="GeneID" id="2739512"/>
    <dbReference type="KEGG" id="tde:TDE_0828"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.797"/>
    <dbReference type="eggNOG" id="COG0445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_12"/>
    <dbReference type="OMA" id="FRPGYAI"/>
    <dbReference type="OrthoDB" id="146811at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000117205" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG">
        <location>
            <begin position="1"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <sequence length="628" mass="70228" checksum="020D7F82D70F4CDC" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PI8</accession>
    <name>Q73PI8_TREDE</name>
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        <submittedName>
            <fullName evidence="2">Efflux protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971421.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682069.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0811"/>
    <dbReference type="EnsemblBacteria" id="AAS11302">
        <property type="protein sequence ID" value="AAS11302"/>
        <property type="gene ID" value="TDE_0811"/>
    </dbReference>
    <dbReference type="GeneID" id="2739553"/>
    <dbReference type="KEGG" id="tde:TDE_0811"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.783"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_0_0_12"/>
    <dbReference type="OMA" id="WAFPITE"/>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="455" mass="49957" checksum="6BA6BF836B84BC11" modified="2004-07-05" version="1">MENEKQKEFILNGNLWKVIFDLSWPAVIAMILLGANNVLDGIFVGHFAEEGAFAGISVALPPIITIIGLGILIGSGAGTLLSIAIGAEDKNIQKKILGNVNFLTLIISVIVMTLGFLFSEQTLFLMGGRGNALIHGSKYYRTILWGTPIWIYAIALNNLIRSEGKMKTAAAIMGISLIVNGCANYTLMVIFNFGIKGAAIGTNIGMAVQAIISTLYFAKKNPDSPVSVFTIRIDGEIISKIISMGLASFIMQFMGTIQMLLVLNVLNHYGSQDDIAFYGIITRIFSFILQTIGGFMIALSPIIGINFGADKTERLISAFKRFVFAALILIAPLWILILIFPQTSVSLMMKNPHLSIHNISYFRIYMALLPVMPLVFFALAFFPAVNKGKISSILGILQQIVFYIPIMLILPIFIGIAGIYYGTFLIEILSAIPISILIIREFRLLRSGITKWQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PJ3</accession>
    <name>Q73PJ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971416.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682064.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0806"/>
    <dbReference type="EnsemblBacteria" id="AAS11297">
        <property type="protein sequence ID" value="AAS11297"/>
        <property type="gene ID" value="TDE_0806"/>
    </dbReference>
    <dbReference type="GeneID" id="2739548"/>
    <dbReference type="KEGG" id="tde:TDE_0806"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.778"/>
    <dbReference type="eggNOG" id="COG3428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093409_2_0_12"/>
    <dbReference type="OMA" id="MIDYKTA"/>
    <dbReference type="OrthoDB" id="1845504at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018649">
        <property type="entry name" value="SHOCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039519">
        <property type="entry name" value="YokE-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14470">
        <property type="entry name" value="bPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09851">
        <property type="entry name" value="SHOCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bPH_3" evidence="2">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="SHOCT" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="182" mass="20407" checksum="C93EEB4D750745A8" modified="2004-07-05" version="1">MKTLEAIQAEIKALGDVDLFGTKKEVNCLPEIMKDSEHILYLTSGLMDGTTWLIVCTEERIILLDKGMFFGMKQTEMSLDKINSISYNKGLLLGSIEIWHGGARMIIENCTKESVKPFVDAVNNAIENRKTRSSEANVQKAVQNGSSTIDIADQLERLISMVEKGFLSQEEFETQKQKLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PJ7</accession>
    <name>Q73PJ7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-bd_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971412.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682058.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0802"/>
    <dbReference type="EnsemblBacteria" id="AAS11293">
        <property type="protein sequence ID" value="AAS11293"/>
        <property type="gene ID" value="TDE_0802"/>
    </dbReference>
    <dbReference type="GeneID" id="2740680"/>
    <dbReference type="KEGG" id="tde:TDE_0802"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.775"/>
    <dbReference type="eggNOG" id="COG2910">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025711_3_2_12"/>
    <dbReference type="OMA" id="DWTFLSP"/>
    <dbReference type="OrthoDB" id="948454at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="8"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="211" mass="23541" checksum="D0CF943BFEC41ED4" modified="2004-07-05" version="1">MKKIAIIGANGKQGHCLTNEAVMRGFDVTAIIRQPCAKNKKAKVLQKDLFDLKPEDLAGFDAVIDAFGAWTPETFDRHITSLRHLCDCVKNTKIRLLIVGGAGCLYTDKEHKTILLNAPNFPEEFRPLAQAETNAFLELKERKDVLWTYLSPPLDFKAEGKRTGKYKLAGKDLPFNSNGESTISYADYAIAMIDEVENGKFIQDNFSVVSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PL6</accession>
    <name>RL18_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplR</name>
        <name type="ordered locus">TDE_0783</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971393.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670026.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PL6"/>
    <dbReference type="SMR" id="Q73PL6"/>
    <dbReference type="STRING" id="243275.TDE_0783"/>
    <dbReference type="EnsemblBacteria" id="AAS11274">
        <property type="protein sequence ID" value="AAS11274"/>
        <property type="gene ID" value="TDE_0783"/>
    </dbReference>
    <dbReference type="GeneID" id="2740661"/>
    <dbReference type="KEGG" id="tde:TDE_0783"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.756"/>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_12"/>
    <dbReference type="OMA" id="NKQIYAQ"/>
    <dbReference type="OrthoDB" id="1963491at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000131375" description="50S ribosomal protein L18">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <sequence length="120" mass="13696" checksum="27861023DB8AD847" modified="2004-07-05" version="1">MDKKRNDKDRKRFKRKMHIRKSIFGTAERPRMTVFRSNKRISVQVIDDVEGKTLAAVSTMEEALRSLKVNVESGAKVGEEIGKRLKEKNIDTVVFDRNGYLYHGVVKAVADGARKTGIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PX1</accession>
    <name>Q73PX1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-ADP-ribose hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0674</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O = ADP-D-ribose + H(+) + L-aspartyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54428"/>
            <dbReference type="Rhea" id="RHEA-COMP:9867"/>
            <dbReference type="Rhea" id="RHEA-COMP:13832"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:138102"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971287.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681886.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0674"/>
    <dbReference type="EnsemblBacteria" id="AAS11168">
        <property type="protein sequence ID" value="AAS11168"/>
        <property type="gene ID" value="TDE_0674"/>
    </dbReference>
    <dbReference type="GeneID" id="2739667"/>
    <dbReference type="KEGG" id="tde:TDE_0674"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.655"/>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_2_1_12"/>
    <dbReference type="OMA" id="QGHEEPT"/>
    <dbReference type="OrthoDB" id="1812319at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02906">
        <property type="entry name" value="Macro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035801">
        <property type="entry name" value="Macro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="4">
        <location>
            <begin position="70"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="278" mass="31008" checksum="283C97B5F49F4EA3" modified="2004-07-05" version="1">MTQTERRRFLIEYLLAENSQYRGVQIPESETEQKYLLRSLVNVRHAVPASEEFLHIEDEYLQEEIKLRGITDITDLVPACDDLYIWRGDITTLKVDAIVNAANSGMTGCWQPCHYCIDNCIHTFAGIRLRAACDSIIKKQGHEEPTGQAKITLAFNLPCKFVLHTVGPIVEGQLTQTDCDLLSSCYKSCLHLSHDKGLRSIAFCCISTGVFGFPQEEAAQIAVAAVREWKEKNETSGSSPNMAGTTGGMKVVFNVFTEKDEEIYRGLFSGAKNKGTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q24</accession>
    <name>Q73Q24_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971234.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681806.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0620"/>
    <dbReference type="EnsemblBacteria" id="AAS11115">
        <property type="protein sequence ID" value="AAS11115"/>
        <property type="gene ID" value="TDE_0620"/>
    </dbReference>
    <dbReference type="GeneID" id="2740465"/>
    <dbReference type="KEGG" id="tde:TDE_0620"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.598"/>
    <dbReference type="eggNOG" id="ENOG5033874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1119764_0_0_12"/>
    <dbReference type="OMA" id="WIIGYSE"/>
    <dbReference type="OrthoDB" id="1381586at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="271" mass="31488" checksum="B262110F1847B651" modified="2004-07-05" version="1">MEKDKWNAFCKFKSEYKNECMHYLDILGYKYKEPSLENCAAQSFKKENASFFKEGLAVLQEEAALAGKTPPYPVETPIVYNHSWDSISQDDEIKLIVIGDNPGKNEQLHKNQKYLVGLAGKIADNFFKKNPSFGIDFRKNVIILNKTPIHTAKTKQLDYILKKDADGSFKKFYEESQIFTAQKTAELQKKLGCPIWLVGYSELKPRGLFYAYANEMKNLYADKKEPQIYLYQHFSMNRFLIDLKDNYDQSLSLEKNLSLLGIKHRNEILDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q79</accession>
    <name>Q73Q79_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971178.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681734.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0564"/>
    <dbReference type="EnsemblBacteria" id="AAS11059">
        <property type="protein sequence ID" value="AAS11059"/>
        <property type="gene ID" value="TDE_0564"/>
    </dbReference>
    <dbReference type="GeneID" id="2741000"/>
    <dbReference type="KEGG" id="tde:TDE_0564"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.548"/>
    <dbReference type="eggNOG" id="ENOG502ZAYD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1271834_0_0_12"/>
    <dbReference type="OrthoDB" id="854192at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025412">
        <property type="entry name" value="DUF4304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14137">
        <property type="entry name" value="DUF4304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="216" mass="24990" checksum="39A964DF881657D2" modified="2004-07-05" version="1">MKPRELCEKAWQEIARNFPDFKVLGKGKTLRKIANNKDIIFEIYFQANRYNCESNVEFIPHINIYSKAMKKAGITGEGIIYGGELSSLAGRKAGAWWQLAGASYKDTVTQITGLLHKHIMPLFADFEDTNKNIERILNGSLKGYALLYYIYYFGGKEPAERYFNKVIKEDKLKKKYISFYNSLKEIPKENIDLHFEDFYGASLIKFAYLHGLEIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q82</accession>
    <name>Q73Q82_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971175.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672474.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0561"/>
    <dbReference type="EnsemblBacteria" id="AAS11056">
        <property type="protein sequence ID" value="AAS11056"/>
        <property type="gene ID" value="TDE_0561"/>
    </dbReference>
    <dbReference type="GeneID" id="2739806"/>
    <dbReference type="KEGG" id="tde:TDE_0561"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.545"/>
    <dbReference type="HOGENOM" id="CLU_1873568_0_0_12"/>
    <dbReference type="OrthoDB" id="1989671at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028228">
        <property type="entry name" value="Imm53"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15580">
        <property type="entry name" value="Imm53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="132" mass="15339" checksum="2C998BB3458F3F67" modified="2004-07-05" version="1">MRSIVDWLQDWTKTQIDGDWEHEQGISIGMLDNPGWILRADISNYGDFLKASEPLGRDNDEDWIDFEIRIIAKTYVYIEIFGDINKLNQILHSFKAIIEELEEIEKRGIGILSSQRIKEIIDSVSQSLKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QA7</accession>
    <name>Q73QA7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971150.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681682.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0536"/>
    <dbReference type="EnsemblBacteria" id="AAS11031">
        <property type="protein sequence ID" value="AAS11031"/>
        <property type="gene ID" value="TDE_0536"/>
    </dbReference>
    <dbReference type="GeneID" id="2741755"/>
    <dbReference type="KEGG" id="tde:TDE_0536"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.522"/>
    <dbReference type="eggNOG" id="ENOG502Z86A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091310_0_0_12"/>
    <dbReference type="OMA" id="YWTAFAY"/>
    <dbReference type="OrthoDB" id="1919328at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="266" mass="30975" checksum="8474F1F30384FD25" modified="2004-07-05" version="1">MAIDGVKIIDSDDGYDIYNTIVERYKDGGNIDAIIEDVLNDEHNFCIDPFYTEIYWTAFAYSLWKVGHLPEKIKNKALEIIAKGADDFWLEIDGKALKQRQKELDKLAVQLQSENPKPIKVPKTKIKRDPYFKVGEVLAVKFENEYGAVFVSDVDQSPRKIEYHLACTRLLQKDKPTMDDFLNSEIACKKQNTKYALDTDCWFNHKDLGLLLDKLEKIGEVVFEDYALWSLSPAHTLENIYEEITADKEVWHLRFMETYHLIKEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QB6</accession>
    <name>Q73QB6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0527</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971141.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681664.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0527"/>
    <dbReference type="EnsemblBacteria" id="AAS11022">
        <property type="protein sequence ID" value="AAS11022"/>
        <property type="gene ID" value="TDE_0527"/>
    </dbReference>
    <dbReference type="GeneID" id="2741746"/>
    <dbReference type="KEGG" id="tde:TDE_0527"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.513"/>
    <dbReference type="eggNOG" id="ENOG50310XS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1053526_0_0_12"/>
    <dbReference type="OMA" id="SIEWISV"/>
    <dbReference type="OrthoDB" id="885064at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="264" mass="30618" checksum="C849CC9B148533E9" modified="2004-07-05" version="1">MIYIKFYTKSKGCLEDINRKLSAEIEKIINNPDADIIYQSPHTNKIIWASKRLNENCVSIIAFDETANKIASIKMEDELSDSDIAFTSLNEENRIIVSFTAGQDGSQDYCIELNNNELKIIYKFPKNLSYMFSFDKYAFLADFYSSAFFKISSSDFTPIAENTYSLFKEDSLSNVQKINDSFGIFCTTEGKCYVFDLSALELIDELIIDCKIDDLEKNWTVNALFQTRDEMIFQYCNYKNGKESIEWISVDKLYLDRIIKEQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QE3</accession>
    <name>Q73QE3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971114.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10995">
        <property type="protein sequence ID" value="AAS10995"/>
        <property type="gene ID" value="TDE_0500"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0500"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.486"/>
    <dbReference type="HOGENOM" id="CLU_3298091_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="40" mass="4624" checksum="7F576A0CF29BA7BE" modified="2004-07-05" version="1">MSVYAIKEKTLVTLKIKDSRQLGNMAVEKQLKYDVILNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QI1</accession>
    <name>Q73QI1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971076.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681556.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0462"/>
    <dbReference type="EnsemblBacteria" id="AAS10957">
        <property type="protein sequence ID" value="AAS10957"/>
        <property type="gene ID" value="TDE_0462"/>
    </dbReference>
    <dbReference type="GeneID" id="2739216"/>
    <dbReference type="KEGG" id="tde:TDE_0462"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.448"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090346_0_0_12"/>
    <dbReference type="OMA" id="DTDHVGA"/>
    <dbReference type="OrthoDB" id="733552at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="41"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="269" mass="30495" checksum="7EF8AB3AB43294EC" modified="2004-07-05" version="1">MSLMDYFAIHVVPKLYRGKGAFHPAETGKLTETVSCVREYDVNIFFIRKGNTLIAIDSGYKNHHALLPGCKKIEIDPKAVQALFLTHADPDHAGGLDIRCENCFINAEIYLGEIEENYLTNTIYRKKIGPFGLKNSVKIKDNYHLLKDGQSVSVGDLTIQPFLVPGHTLGHLMYLIDNELLFTGDSIALNQEGGWCFFDLFNYNSEMNIKSLKTLKEKLDLNRIKYVFTSHNGFTDKAKEAFAHVDVIPKWNEKGFIFDKTAPYDCFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QL6</accession>
    <name>Q73QL6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971041.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0427"/>
    <dbReference type="EnsemblBacteria" id="AAS10922">
        <property type="protein sequence ID" value="AAS10922"/>
        <property type="gene ID" value="TDE_0427"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0427"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.414"/>
    <dbReference type="eggNOG" id="ENOG5032J49">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046708_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="457" mass="53211" checksum="18D005874E8B9CCA" modified="2004-07-05" version="1">MVKKFFYIFICCILSSLYAIEYEEFIAGVLTNSNEYQKALSKYNIKKTTAQKIQYRWIPKLSLKLNYISNVEIKTHDQIHAFTTGLNLKQTLPMGMGLTFNIDNTFALSKIKGIKNEYSSSAKTQFSMPLYFFAPAILKPYSEHEFYLGENSISFADLELQRIKEKIIAEAIYVAVSYWLQKKTIAIEEEKSQIDLQLGLNDEALWKQGKLSTLELSERNTKRYNNQLNLLNSKKRYLQMLHTLNLTGMSADAMPSNIESWIKKLESYISHEYINTDAEFLLKQKQLKVNQYYTLKEQLNRLPSFIFSFTLDPASKSKGGVKFKDTIQNYWKAEKDWLFNFAIGINIPLSPLDEVYDIDKTTKELLNLNKLEIEALSMNYQNKKEVHEINLNILNEVCILAEKNKENIQNRLASSEVLLKQGYITEIDFKIQNLDYQLSQLNSLKARLDYIIEVLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QP5</accession>
    <name>Q73QP5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligopeptide/dipeptide ABC transporter, periplasmic peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0398</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971012.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681422.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0398"/>
    <dbReference type="EnsemblBacteria" id="AAS10893">
        <property type="protein sequence ID" value="AAS10893"/>
        <property type="gene ID" value="TDE_0398"/>
    </dbReference>
    <dbReference type="GeneID" id="2739407"/>
    <dbReference type="KEGG" id="tde:TDE_0398"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.387"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_6_12"/>
    <dbReference type="OMA" id="KESPWVP"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285903" evidence="1">
        <location>
            <begin position="23"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="83"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="527" mass="58928" checksum="CC648DA567C89A23" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QP6</accession>
    <name>Q73QP6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0397</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971011.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676754.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0397"/>
    <dbReference type="EnsemblBacteria" id="AAS10892">
        <property type="protein sequence ID" value="AAS10892"/>
        <property type="gene ID" value="TDE_0397"/>
    </dbReference>
    <dbReference type="GeneID" id="2739406"/>
    <dbReference type="KEGG" id="tde:TDE_0397"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.386"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_12"/>
    <dbReference type="OMA" id="PRHTVYD"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="325" mass="36788" checksum="04A10601D8FAC7CF" modified="2004-07-05" version="1">MKEFISIQNIKKFYPVKKGKSLFTKSRSFVKALDNINLELKQGEILGLIGESGCGKSTLGRILSRLEEPTDGDVYIDGLSTKQIMKNDSKGFRRLVQIIFQNPYDSFTPKNTIEEILLRPLKIHNIAENDAERKKILITELENGGLHPAADFLKRYPHQLSGGQLQRISIIRAMLLKPQFIIADEPVSMLDVSVRADIINMLLNLKKQYNATIVFISHDISLTRYISDKIAVMYLGRIVEYGDADDIIKNPKHPYTKVLISNCGSSDPTEKTEKIFIQGEPPTPIDPKDMCYFAPRCFMATDECFGSYPDTKKLYEGHIAACHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QR9</accession>
    <name>Q73QR9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970988.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681391.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0374"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="DNASU" id="2740126"/>
    <dbReference type="EnsemblBacteria" id="AAS10869">
        <property type="protein sequence ID" value="AAS10869"/>
        <property type="gene ID" value="TDE_0374"/>
    </dbReference>
    <dbReference type="GeneID" id="2740126"/>
    <dbReference type="KEGG" id="tde:TDE_0374"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.364"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032290_0_0_12"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="226"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="428" mass="48573" checksum="B6B0C378E8DB5D64" modified="2004-07-05" version="1">MKILHCLAQLPMKTGSGVYFSTLVEGMIKKGHENAVLYGTQLPFAEKTFNESLPDKLQGSVKEYPIKFLSDYEQEEKTVFNADLPFPIAGMSDIMPYTSTVYSKMSDEMYQKWISVFEKTLLRAKEEFNPDIIISHHLFILTSLVKKIFSGKKIIGISHGTDIRQIKKNPWIKTRYIQNLDKLDLYFTVSPKDIAEAQTIFSAPPEKIKLAGGGFNPDIFNDKDRHIFDGTFKLCYAGKISDSKGVFELAKTLPLILKKYPNTELTLIGNATEEQKNILLKNAGFNENLKIVNASSQICMCKILKQNDIFILPSYYEALGLVAVEALACGLFTVTTEIEGLINLLGEKINTSGIIEFVKLPRIYDVDKAYEEDKPAFVEALSEKIMLQMERLKSQKDFYSPVAEEIKKHSWESIIDRIEEEIKGTFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QS2</accession>
    <name>Q73QS2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970985.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681385.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0371"/>
    <dbReference type="EnsemblBacteria" id="AAS10866">
        <property type="protein sequence ID" value="AAS10866"/>
        <property type="gene ID" value="TDE_0371"/>
    </dbReference>
    <dbReference type="GeneID" id="2740123"/>
    <dbReference type="KEGG" id="tde:TDE_0371"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.361"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444062_0_0_12"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="82"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="615" mass="71246" checksum="7F05EA6FE3C516C4" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QX0</accession>
    <name>Q73QX0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970937.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0323"/>
    <dbReference type="EnsemblBacteria" id="AAS10818">
        <property type="protein sequence ID" value="AAS10818"/>
        <property type="gene ID" value="TDE_0323"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0323"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.312"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026769_2_0_12"/>
    <dbReference type="OMA" id="ITIGVHR"/>
    <dbReference type="OrthoDB" id="727832at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011435">
        <property type="entry name" value="UmpAB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07556">
        <property type="entry name" value="DUF1538"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="481" mass="51367" checksum="CB6C0E654A4E4CAB" modified="2004-07-05" version="1">MSVLPIVILITILNFAFIHIDYSVFIRFLIGSVCIILGLAFFLFGIEMSVTKIGLQMGKEITKRNNILILILGGFALGFLISIAEPDLQILASQVNTVTKSGIPALRLIVVVSIGVAAFVVFGILRTVFNISQKIIFALSYGVIFLLSLFSSSEFISISFDSSGTTTGAITVPFILALAAGVSEMKKDSAASERDAFGLVGMASAGAIVAVLALSVFGKTKEISADDFVFNLDIHSQIFYPFAKHFLPVLYECLLSLLPLTLIFLITNFVSIKLRAKDLIPIIKGLIITLIGLFLFMWGAKSGFLDVGIAMGSRLGEIGTRSLILFIGALIGIVSILAEPAVYVLTVQIENVTSGHIPRKIVLTFLCIGVSFAVMLSLLRIIEPSFQLWHMLLPGYIVSLLLSIIVPDLFVSIAFDAGGVASGPMTATFVLSLAQGLANSTPTANVLIDGFGIIAAVALAPIISLQILGLIFKIKSAGEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QX4</accession>
    <name>Q73QX4_TREDE</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970933.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666315.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0319"/>
    <dbReference type="EnsemblBacteria" id="AAS10814">
        <property type="protein sequence ID" value="AAS10814"/>
        <property type="gene ID" value="TDE_0319"/>
    </dbReference>
    <dbReference type="GeneID" id="2739326"/>
    <dbReference type="KEGG" id="tde:TDE_0319"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.308"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_12"/>
    <dbReference type="OMA" id="SRAWAWL"/>
    <dbReference type="OrthoDB" id="688156at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="40"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="263"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="335" mass="36718" checksum="03A25B14B7EFACAF" modified="2004-07-05" version="1">MIDTSYKTIVENFKAKMAERIVGQQELIEGILTAYIAGGHVLLEGVPGLAKTLIVKTFAELSNVSFKRIQFTPDLLPADLIGTLIYQQSIGKFSVRRGPVFANIVLADEINRAPAKVQSALLEAMAEGQVTIGENSFSLPAPFFVLATQNPIEQEGTYPLPEAELDRFLLKLFVPYPSIEEEINIVNKFSSLRPSQNLGQSSNISPAEAVLTPENLETLRNAVEQVKCSPEITSYIVSIIAATRPAKNVKQDDYIHGNYLSYILYGASPRAGIAIQKCAKIKALFNGRDYVIPEDVKAVAYAALRHRLKLSYEAAADNLTADDIIEKLLGIVPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R09</accession>
    <name>Q73R09_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970898.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666370.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0284"/>
    <dbReference type="EnsemblBacteria" id="AAS10779">
        <property type="protein sequence ID" value="AAS10779"/>
        <property type="gene ID" value="TDE_0284"/>
    </dbReference>
    <dbReference type="GeneID" id="2741601"/>
    <dbReference type="KEGG" id="tde:TDE_0284"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.274"/>
    <dbReference type="eggNOG" id="ENOG50321KG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093450_1_0_12"/>
    <dbReference type="OMA" id="IFQPWTI"/>
    <dbReference type="OrthoDB" id="1668819at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011733">
        <property type="entry name" value="CHP02185_IM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09605">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02185">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="200" mass="21737" checksum="199F9D659434944F" modified="2004-07-05" version="1">MKNKKTNTLQTKDFISIGVFSLVYFAAAFIIGGVAQMTPVTFPFMPMIVALFAGSIFMLYTAKIPKRGAISILGILAGLLLFITGMFWMMSVFFIIFGFIADGIASFGEFKSFKKNLTAYCIFALAPMGAYIPMAVMPAQFDAFMRKKGDFSSFAEVINAIGANRWVVPAMIAGTVVCAIIGGMIGKKLLKKHFEKAGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R33</accession>
    <name>Q73R33_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970874.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681187.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0259"/>
    <dbReference type="EnsemblBacteria" id="AAS10755">
        <property type="protein sequence ID" value="AAS10755"/>
        <property type="gene ID" value="TDE_0259"/>
    </dbReference>
    <dbReference type="GeneID" id="2739684"/>
    <dbReference type="KEGG" id="tde:TDE_0259"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.254"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_11_0_12"/>
    <dbReference type="OMA" id="KIHEELH"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="150" mass="16911" checksum="B4A322177C211250" modified="2004-07-05" version="1">MNDVESLIRRTAKIQYKVNANDKKPRTFGTQHKLYQSEIHFIEAIGLDGGYSASELSEKLGITNGAVTQVADKLLKKKLIEKYKKADNKKTVYFKLTKEGTVAYNNHEKFHAGFNEKLAAYLSSLSKKEFDAIARLAELVDNNIPDLSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R50</accession>
    <name>Q73R50_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970857.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681155.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0241"/>
    <dbReference type="EnsemblBacteria" id="AAS10738">
        <property type="protein sequence ID" value="AAS10738"/>
        <property type="gene ID" value="TDE_0241"/>
    </dbReference>
    <dbReference type="GeneID" id="2741440"/>
    <dbReference type="KEGG" id="tde:TDE_0241"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.235"/>
    <dbReference type="eggNOG" id="ENOG502ZT2I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093450_4_0_12"/>
    <dbReference type="OrthoDB" id="1668819at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011733">
        <property type="entry name" value="CHP02185_IM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09605">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02185">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="200" mass="22068" checksum="46EA8AD11105DC5B" modified="2004-07-05" version="1">METKTNKLNARDFIFIGIFAAVALLIFFITGALAALTLFGTIANIPITLFFVSIAFMLAVSKVRKTGVFFIMGIIIVLPGFMAANGIGVGLSIIGWFIAETLASTMKYKDKKAIILSYVLGSTLQTALFTLPMYLSHGEYFVQRKEILHLTDEALQQYLQVVGSWQMYGSMIALTVITSFAGAWISMRILKKHFEKAGMV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R54</accession>
    <name>RNY_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease Y</fullName>
            <shortName evidence="1">RNase Y</shortName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rny</name>
        <name type="ordered locus">TDE_0237</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970853.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681149.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73R54"/>
    <dbReference type="SMR" id="Q73R54"/>
    <dbReference type="STRING" id="243275.TDE_0237"/>
    <dbReference type="EnsemblBacteria" id="AAS10734">
        <property type="protein sequence ID" value="AAS10734"/>
        <property type="gene ID" value="TDE_0237"/>
    </dbReference>
    <dbReference type="GeneID" id="2739832"/>
    <dbReference type="KEGG" id="tde:TDE_0237"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.230"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028328_1_0_12"/>
    <dbReference type="OMA" id="PHAILGM"/>
    <dbReference type="OrthoDB" id="1012190at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000344970" description="Ribonuclease Y">
        <location>
            <begin position="1"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="199"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="325"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01175"/>
        </source>
    </evidence>
    <sequence length="509" mass="58024" checksum="C4494C795278B6AA" modified="2004-07-05" version="1">MNWILYVILPAVCIILGWTIRWLYARFQLSASEQRAERILQEAIKDAEAQKKEFLLEAKEQLIREQKQQERENRERRSDLQRFERRLAQKEEVLDKRVETVEKQEKELIKREAALDERTEILSGEEERYREELERISGLTQQQAKDLIIRDLEAEAKHDAVTIINKIEQEAQLTAEKKAQDILITTIQRLATETASDITVSTVSLPSDEMKGRIIGREGRNIRALETLTGVDIIIDDTPEAVVVSCFDPVRKEIARVALERLILDGRIHPARIEEIVQKVTREISQKVYEEGEKVLFDLGIHNMNQEGVRALGRLYFRTSYGQNVLQHSKEVAIIAGMIASEIGANVEIAKRGALLHDIGKGAETDSDKNHAEIGMELAKRINEDPRVVNAVGAHHNDIEPTCIESVIVQIADAISAARPGARRETMDNYVKRLENLEQLAEGFNGVEKAYAIQAGRELRVVINNEKISDADTKILARDIAKKIENDLQYPGRIRVTLIRETRIVEYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R55</accession>
    <name>Q73R55_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970852.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666459.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0236"/>
    <dbReference type="DNASU" id="2739831"/>
    <dbReference type="EnsemblBacteria" id="AAS10733">
        <property type="protein sequence ID" value="AAS10733"/>
        <property type="gene ID" value="TDE_0236"/>
    </dbReference>
    <dbReference type="GeneID" id="2739831"/>
    <dbReference type="KEGG" id="tde:TDE_0236"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.229"/>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124456_3_1_12"/>
    <dbReference type="OMA" id="FYILRRQ"/>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="136" mass="15747" checksum="7796E785C8CEC8B9" modified="2004-07-05" version="1">MKVLLDTNIIVDFLSKRPVFFNEAEKIISKCRDGEIIGIVAVHTVSTLFYLLKKYVSPETLRDIFYNLFEIIEIGRADKNSVLEALKNTEFTDFEDGLQYQCALEEFVDCIITRNKKDFFSSKIPVYTPSEFLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R67</accession>
    <name>Q73R67_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970840.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0224"/>
    <dbReference type="EnsemblBacteria" id="AAS10721">
        <property type="protein sequence ID" value="AAS10721"/>
        <property type="gene ID" value="TDE_0224"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0224"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.217"/>
    <dbReference type="HOGENOM" id="CLU_3318656_0_0_12"/>
    <dbReference type="OrthoDB" id="2020574at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="39" mass="4577" checksum="D19EC025722F272A" modified="2004-07-05" version="1">MYTIKLSEIAANYIASLDKKHDIYELMKKYIKTGLLDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R72</accession>
    <name>Q73R72_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970835.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681120.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0219"/>
    <dbReference type="EnsemblBacteria" id="AAS10716">
        <property type="protein sequence ID" value="AAS10716"/>
        <property type="gene ID" value="TDE_0219"/>
    </dbReference>
    <dbReference type="GeneID" id="2741125"/>
    <dbReference type="KEGG" id="tde:TDE_0219"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.212"/>
    <dbReference type="eggNOG" id="COG5512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1618282_0_0_12"/>
    <dbReference type="OrthoDB" id="2050734at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="162" mass="18657" checksum="4AA1582C1328F3DD" modified="2004-07-05" version="1">MKLFKTSKEIVDNFSQKFNEMAEISSNLNNEQALSVFEGWEKVIGDKKLAAYCELYDIKNETAIIKTGHTGWSQQLLMRKKKILYNFKKFYPALDVKNISIVVESEFELKRNSDVSENLNQNLSIDIEEDNPKTTDEPDKPLPPELAKALKSLKKSILKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RD0</accession>
    <name>Q73RD0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970776.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673158.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0160"/>
    <dbReference type="EnsemblBacteria" id="AAS10657">
        <property type="protein sequence ID" value="AAS10657"/>
        <property type="gene ID" value="TDE_0160"/>
    </dbReference>
    <dbReference type="GeneID" id="2741761"/>
    <dbReference type="KEGG" id="tde:TDE_0160"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.158"/>
    <dbReference type="eggNOG" id="ENOG5032N8M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1427103_0_0_12"/>
    <dbReference type="OMA" id="GSDMLEY"/>
    <dbReference type="OrthoDB" id="1924894at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="183" mass="21221" checksum="9F8849F0B31CEFC9" modified="2004-07-05" version="1">MDIKTKIELTPEEETALKGILNCDDVKLKQYVNKFASASIEEYCRMILGQKVFTRFNDIREYRLFLIIKEVFNNRIPDDQIISDLFQTTPTESRSLARSIASKYQYELREAISETLKEIISNASEKKGKYVFTLNSSTKVEELNKILISIDGTLPKIKKDSDSVSQYIVEKSSYNKLKEHFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RD9</accession>
    <name>Q73RD9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease BN-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970767.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681017.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0150"/>
    <dbReference type="EnsemblBacteria" id="AAS10648">
        <property type="protein sequence ID" value="AAS10648"/>
        <property type="gene ID" value="TDE_0150"/>
    </dbReference>
    <dbReference type="GeneID" id="2740838"/>
    <dbReference type="KEGG" id="tde:TDE_0150"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.148"/>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049883_0_0_12"/>
    <dbReference type="OMA" id="WMARRFF"/>
    <dbReference type="OrthoDB" id="1502844at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="4">
        <location>
            <begin position="314"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="435" mass="50618" checksum="B18E54A7285E8FA6" modified="2004-07-05" version="1">MKKEKSNSQKFLAWYERVVQEQKKGLYDFNQKIYITIVSFVNNDLLTTAAAGAYNFLMSALPIFILTLTILLRVLKQSPQQIKEALRALSIFQNTVNLDRFFHFLLNVNSFSFFEFIVLIFVLWMARRFFATIQHSIRKVYRKKIKITPLKTSLIVILGEIIVVILLVFLFIFLITGSAVFRSDFAQPVFSPNLFSLLRNLFRFIPVIFMQLFVCLIYYWMPPIKPSFKTALLSSAACTLSYYFVKIFFSFFRSTVKFTFVYGLFTNVILVLIQVWFFFFFFVFFAQFMYVNQFFNSFIISQLYRLPKEDAPGFFNQLLRHLFITPPKEYRKQAIEIKAGETIFNYEDESSEIYYIIEGSVSVTRLNKILNFGKGDLFGELACLLNGKRTGTAIAETDCLLAVIPEKLFLEAISIDGNVSRQALKILAESLIDQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RF3</accession>
    <name>Q73RF3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970753.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681000.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0136"/>
    <dbReference type="DNASU" id="2741331"/>
    <dbReference type="EnsemblBacteria" id="AAS10634">
        <property type="protein sequence ID" value="AAS10634"/>
        <property type="gene ID" value="TDE_0136"/>
    </dbReference>
    <dbReference type="GeneID" id="2741331"/>
    <dbReference type="KEGG" id="tde:TDE_0136"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.136"/>
    <dbReference type="eggNOG" id="COG3862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148086_0_0_12"/>
    <dbReference type="OrthoDB" id="1751763at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036593">
        <property type="entry name" value="CPE0013-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012460">
        <property type="entry name" value="DUF1667"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39450">
        <property type="entry name" value="PTHR39450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07892">
        <property type="entry name" value="DUF1667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160148">
        <property type="entry name" value="SSF160148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="118" mass="12634" checksum="A55CD31DC8445FEE" modified="2004-07-05" version="1">METKSLICTACPRGCRLSVKIENENISVSGNKCPKGLSYGKTEAVCPMRILTSTIASSVEGFPRLPVKTSVEVPLKNFSEYMHLIRKLKADSSKMPGDIIVKNFAESGADLIAAGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RF6</accession>
    <name>Q73RF6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970750.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680996.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0133"/>
    <dbReference type="EnsemblBacteria" id="AAS10631">
        <property type="protein sequence ID" value="AAS10631"/>
        <property type="gene ID" value="TDE_0133"/>
    </dbReference>
    <dbReference type="GeneID" id="2739445"/>
    <dbReference type="KEGG" id="tde:TDE_0133"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.133"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_959570_0_0_12"/>
    <dbReference type="OMA" id="LCENISY"/>
    <dbReference type="OrthoDB" id="1875458at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="249" mass="29132" checksum="2CE0874D3B4D6C49" modified="2004-07-05" version="1">MKSEEQSLKKEKIASLIQDEILTGRFLAGEYLLPERELADHFDVSRPVVHEALLILQSKGLITMRPRHGCIVNDLSSSISMRLLTELYRNKQISEPEKIEAGLVEFRQLILTHIIKKLINRISKLSVKERYHLFLPLKNKIHFSRSEDIETSAIEDFEFYRTLIDLSDSPIFLLSLETAKEIYKYQFKQFLCENISYADRIPEYKQLFFNALIEADEENSIKVMIKLTQPETYRDAELDNSMRGGCRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RR8</accession>
    <name>Q73RR8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_0017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970634.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673388.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10515">
        <property type="protein sequence ID" value="AAS10515"/>
        <property type="gene ID" value="TDE_0017"/>
    </dbReference>
    <dbReference type="GeneID" id="2741632"/>
    <dbReference type="KEGG" id="tde:TDE_0017"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.19"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053520_0_0_12"/>
    <dbReference type="OMA" id="FETHTRI"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="342" mass="38247" checksum="2151EA4129579F18" modified="2004-07-05" version="1">MNVRYAVELSKELLQIHSPGGYTKNAIDRIKKEFDSLGIKYTETNKGAIYGTIEGKNTAKHRVVSAHADTLGAMVRQIKPNGCLKLAAIGGIAFNSIEGENLYIITRTGKVITGTGLPEKASVHIFESIEKEERNLETFEVRLDAETHSKEETLALGINIGDFVAFEPRTIETEDGYIKSRHLDDKACIGMLFAACKALKEKGEKPAYTTHFFISNYEEIGHGFYGIPKECFEVLALDIGTVGGEQNSDEHAVTIIAKDSRTPYDFGFRHRLENLAIQNKINYRTDVMFRYGSDASMYVLQGFDINFACMGPGVSATHHYERTHIDSYKETINLLYAYLMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7IU52</accession>
    <name>F7IU52_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971676.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682379.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1068"/>
    <dbReference type="EnsemblBacteria" id="AAS11557">
        <property type="protein sequence ID" value="AAS11557"/>
        <property type="gene ID" value="TDE_1068"/>
    </dbReference>
    <dbReference type="GeneID" id="2740829"/>
    <dbReference type="KEGG" id="tde:TDE_1068"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1028"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_12"/>
    <dbReference type="OMA" id="YEPAHPY"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="330" mass="37009" checksum="BF5CB7E2F45642D6" modified="2011-07-27" version="1">MKNPLLEVKNLHTYFFTNKGTIKAVQGVDFTIEAGKTLGIVGESGSGKSITAFSILNLLEYPGKIVQGEINFGGINLVNLGKKEIRKIRGNDISMIFQEPMTSLNPVHRIGRQLSEPLILHQHMSKKEAWAAAIDLLREVKIPNPENVVYNYPFQLSGGMRQRVMIAMALACKPRLLIADEPTTALDVTIQAQIFKLMNDLKKKHNTAIMFITHDLGAIAELADDVAVMYTGEIVERAPVDVIFDRQTQFSHPYKEGLLESIPLLDEEVEYLAQIQGSVPHPLKLPKGCRFSTRCEYATEKCRNEKPELVEVEEGHLIRCFYPKSGGRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J31</accession>
    <name>Q73J31_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973343.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667016.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2745"/>
    <dbReference type="EnsemblBacteria" id="AAS13262">
        <property type="protein sequence ID" value="AAS13262"/>
        <property type="gene ID" value="TDE_2745"/>
    </dbReference>
    <dbReference type="GeneID" id="2740964"/>
    <dbReference type="KEGG" id="tde:TDE_2745"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2591"/>
    <dbReference type="eggNOG" id="COG3177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040460_4_0_12"/>
    <dbReference type="OMA" id="MARLLMN"/>
    <dbReference type="OrthoDB" id="1232677at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="96"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="195"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for autoinhibition of adenylyltransferase activity" evidence="3">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="271" mass="31055" checksum="0152DA73E72CB792" modified="2004-07-05" version="1">MINRNEEQNFNKLSEVINEYNKLQISQQIDYDKFYLYSIITHSTAIEGSTITEIENQLLFDEGISANKPIHEQLMNLDLKAAYEKSFELAKQHTQITPEILCELSVLVMKNTGTVYNTIGGTFSSAKGELRLVNVSAGRGGKSYMAWQKLPQKLEEFCSWLNSERKSIAEKDIEAQYAFSFLAHYKLVHIHPWADGNGRMSRLLMNVIQYEAGLVPAIIKKENRAEYIQSLASSQDKDDPAEFLHFMFSHHIRNLSEQIEEYKNSLEMSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J43</accession>
    <name>Q73J43_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973331.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957305.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2733"/>
    <dbReference type="EnsemblBacteria" id="AAS13250">
        <property type="protein sequence ID" value="AAS13250"/>
        <property type="gene ID" value="TDE_2733"/>
    </dbReference>
    <dbReference type="GeneID" id="2740952"/>
    <dbReference type="KEGG" id="tde:TDE_2733"/>
    <dbReference type="eggNOG" id="ENOG502ZQS9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1677085_0_0_12"/>
    <dbReference type="OrthoDB" id="2140945at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="157" mass="17762" checksum="9BC2D61CB9C90686" modified="2004-07-05" version="1">MIEKRWKSTDRNYNHSHKKSAKSFAKGLDKAETHLIIFSNKQQATSNKQQATSNKQQATSNKQQATSNKQQATSNKQQATSNKRTERYKRAICSMHPEHTQISSTNNTHRTEALSSCVFYITPFKETATPAENAKDYKRMSYTASLKTSCVLGVLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J97</accession>
    <name>Q73J97_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-amylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973276.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957290.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2678"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13195">
        <property type="protein sequence ID" value="AAS13195"/>
        <property type="gene ID" value="TDE_2678"/>
    </dbReference>
    <dbReference type="GeneID" id="2739265"/>
    <dbReference type="KEGG" id="tde:TDE_2678"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2530"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005647_0_0_12"/>
    <dbReference type="OMA" id="AFWLMEG"/>
    <dbReference type="OrthoDB" id="76786at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="341"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1201" mass="139843" checksum="A7017466A4B8A018" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JD4</accession>
    <name>Q73JD4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2641</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973239.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2641"/>
    <dbReference type="EnsemblBacteria" id="AAS13158">
        <property type="protein sequence ID" value="AAS13158"/>
        <property type="gene ID" value="TDE_2641"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2641"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2497"/>
    <dbReference type="eggNOG" id="COG3177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047250_0_0_12"/>
    <dbReference type="OMA" id="SRMEFAK"/>
    <dbReference type="OrthoDB" id="1232677at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="99"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="182"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="219"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for autoinhibition of adenylyltransferase activity" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="328" mass="37639" checksum="21834F6157EF725B" modified="2004-07-05" version="1">MSYEPPFKITSKAINLISQISEKIGEISALENTERTVQLRKKNRIKTIHSSLSIENNSLTIEQITAIIEGKRVLGPPNEIQEVKNAVQAYELLLNLNPYKQNDLLKAHQLMMNDLVKHSGKYRKGGVGIFDGKGVVHVAPPADRVPFLMNDLFDWLKSTDVHPLIKSCVFHYEFEFIHPFEDGNGRMGRLWQTVILTEWKPIFAWLPIETLIKENQKLYYKALGISDNNADSTEFIEFMLSIILKTIKEIITTELKITQKITQKITVNQQKIIASIKNNPYITQEELAEIVGIARLNIIKNMKKLQEQNIIKRIGADKSGYWQIIDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JF4</accession>
    <name>Q73JF4_TREDE</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2621</name>
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    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2621"/>
    <dbReference type="EnsemblBacteria" id="AAS13138">
        <property type="protein sequence ID" value="AAS13138"/>
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    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2621"/>
    <dbReference type="HOGENOM" id="CLU_3159003_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="48" mass="5653" checksum="0B59DB2A5F2EBCC3" modified="2004-07-05" version="1">MLPIFHLGFRLLQNFYIVLRIKNNASMKTITLFPFCFSNNIIHRGSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JI8</accession>
    <name>Q73JI8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacteriocin ABC transporter, bacteriocin-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS12948">
        <property type="protein sequence ID" value="AAS12948"/>
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    </dbReference>
    <dbReference type="GeneID" id="2739855"/>
    <dbReference type="KEGG" id="tde:TDE_2430"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2297"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1395473at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="379" mass="42724" checksum="9365531E3F46483B" modified="2004-07-05" version="1">MKSILYVEDLTYTGEVLQEQKTGIFSSVISIICLLALCTTAWLILGKKEEVVRASGMVRPIENVSFVKSFTAGKIQNIHFTSGQYVEKGAILLSIDDTVAQKERQNLEDLMLKIEEKIKDTEACIKSAEKDLMLVPFERKIAYKRMENYFSVKTNLEKALELNSRIFEEEKALPDFSLANQKIELLNLNVEKSKRDLEQYKNSFFHSLLSEKEALEFQKENLSNSIFKMEESLKLFTVYAPISGEVQEISSLNCGDNVFSGQEILKIVPSSSENIRVVLRLPSSKAGLVREDMKVRLKFPAFPHHEFGSLDGQVETILPDVFLGAKSSEYAVFVKLDGNTLPDKKGMAHFLKVGLDAEASIITETGSILSFILKRLEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JK0</accession>
    <name>Q73JK0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973017.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680355.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2418"/>
    <dbReference type="EnsemblBacteria" id="AAS12936">
        <property type="protein sequence ID" value="AAS12936"/>
        <property type="gene ID" value="TDE_2418"/>
    </dbReference>
    <dbReference type="GeneID" id="2739843"/>
    <dbReference type="KEGG" id="tde:TDE_2418"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2284"/>
    <dbReference type="eggNOG" id="COG2020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065200_4_3_12"/>
    <dbReference type="OMA" id="NLWIRIL"/>
    <dbReference type="OrthoDB" id="1734625at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="167" mass="18814" checksum="B90BEA1F3C9A981C" modified="2004-07-05" version="1">MKKENQEHLPVMGVGPVCIAIMIAFTAAGIALVKFNMLTSGDVGGGVITVLFVIAGILCIAGGIILWYAAVFSAKIDITIKSNRLETGGVYAIVRNPIYSAFLFICIGALLFCRNWYVLILPPLFWVYLTVFMKLTEERWLSERFGEEYKAYSKRVNRFIPWRKIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JM5</accession>
    <name>Q73JM5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972991.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2392"/>
    <dbReference type="EnsemblBacteria" id="AAS12910">
        <property type="protein sequence ID" value="AAS12910"/>
        <property type="gene ID" value="TDE_2392"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2392"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2260"/>
    <dbReference type="HOGENOM" id="CLU_081868_0_0_12"/>
    <dbReference type="OrthoDB" id="1964887at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="225" mass="25620" checksum="A33B526FD75E0C8B" modified="2004-07-05" version="1">MNPEMLPVSALSEKMTSLLSKKKPVFLGEFISLYKKEGPNNPDVSKILRHISGLEGIEYFSNTYQEMRTLYLTSHAVKEVKTSDGLVYERIDDPLNEGFDGLEILARHIDATFGDFIYKYRYLKEGRDIGMVCVNTQKITHPDMSLISLQPDAMALSLAVYDLDDYILIHCLSTAKFPTIPFIGGRVKRAFSSRLTAVYNWFMDEYKCAEKGIEYSAKKKNNSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JN6</accession>
    <name>Q73JN6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973045.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2446"/>
    <dbReference type="EnsemblBacteria" id="AAS12964">
        <property type="protein sequence ID" value="AAS12964"/>
        <property type="gene ID" value="TDE_2446"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2446"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2314"/>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034446_2_1_12"/>
    <dbReference type="OMA" id="HKYAAVV"/>
    <dbReference type="OrthoDB" id="654531at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="4">
        <location>
            <begin position="37"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="3">
        <location>
            <begin position="198"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="491" mass="54004" checksum="3B3C73B690745A82" modified="2004-07-05" version="1">MNSITELFPSDFTDDEKALAKTHFLKKLSVLTHSFYGGKLQTVPKCGLYGFNWFNVWYTPGVSAISTTIRDDNETSFALSNKGNLVAVVSDSTRVLGDGDCTPPGGLGVMEGKCMLMKYLGGVDSYPLCIDSIVRVDEEGKRGVKAGKHDPDKIIDFVRMLEPSVGAVNLEDIQQPDCFKVLDTLREVCEIPVWHDDAQGTACITLAGLLNAIKLAGKKMEDCKIVLLGAGASNTTIARLILADGGKPENMIICDSRGALHSGRKDIEEDKRYYRKWELCLQTNPKKIETFDEAMKGADVLIALSTPGPNTVTKEQVASMNKKAIVFTCANPIPEIWPHEAKAAGAFIVGTGRGDFPNQINNSVCFPGILKGALLVRAKKISDGMAIRCSHSIADYSEKKGINPDNIVVTMQDEDVFAVEAADVAMQAIKEGLARVTMTWDEAYKKAKKDIEESRSLTKMLMEKNFIKEPPQEFYEKALEYAIEQIKKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JQ4</accession>
    <name>Q73JQ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973053.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673991.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2454"/>
    <dbReference type="EnsemblBacteria" id="AAS12972">
        <property type="protein sequence ID" value="AAS12972"/>
        <property type="gene ID" value="TDE_2454"/>
    </dbReference>
    <dbReference type="GeneID" id="2739639"/>
    <dbReference type="KEGG" id="tde:TDE_2454"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2322"/>
    <dbReference type="eggNOG" id="ENOG502ZK2G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784926_0_0_12"/>
    <dbReference type="OrthoDB" id="1164663at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="341" mass="39160" checksum="5BE74464EB2E4D64" modified="2004-07-05" version="1">MGFTIVLLSFGFLALLLFLLTIYIYLRIVIAIGTDTDLPRWIYLIGSSLKGRFSSRQFDYVTDSTALKEATLFILNFVLANIVVFGAIYYRTHHFSKALYMCLKAEFSIVIVVLILSHVIKLIIVLSHRSNKPMYFYASSNAIVASMFFACFAFMLFFSLTGFPSDPIEVQVDKTNVIVGETKASELLSEGFTFYEKTADSEIVNERNDHFYYGKLLEIFRDGKSYGFVSVTPTGKDSDSLKNCVITYYEIDADSKQLSEVTFNHTDLSQLTIQDFKTRDIKDIFSLNPVDSEEIKNDTLFILKMQTTDYVLWKRYRIEANFNEDGTAYRYGARAQHVQWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JR8</accession>
    <name>Q73JR8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0033 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973064.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667494.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2466"/>
    <dbReference type="EnsemblBacteria" id="AAS12983">
        <property type="protein sequence ID" value="AAS12983"/>
        <property type="gene ID" value="TDE_2466"/>
    </dbReference>
    <dbReference type="GeneID" id="2739651"/>
    <dbReference type="KEGG" id="tde:TDE_2466"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2333"/>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165255_0_2_12"/>
    <dbReference type="OrthoDB" id="2042068at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="69" mass="7490" checksum="86C8870E1422D375" modified="2004-07-05" version="1">MSDIIVDARGLACPEPVVLTKKALAVNSAFVVLVDNETSKENIKRFCDNAKAKTKIEPSDDGWKIAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JX0</accession>
    <name>Q73JX0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">radA</name>
        <name evidence="8" type="ordered locus">TDE_2517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973115.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680482.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2517"/>
    <dbReference type="EnsemblBacteria" id="AAS13034">
        <property type="protein sequence ID" value="AAS13034"/>
        <property type="gene ID" value="TDE_2517"/>
    </dbReference>
    <dbReference type="GeneID" id="2739029"/>
    <dbReference type="KEGG" id="tde:TDE_2517"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2382"/>
    <dbReference type="eggNOG" id="COG1066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018264_0_0_12"/>
    <dbReference type="OMA" id="FELMRLA"/>
    <dbReference type="OrthoDB" id="505485at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="72"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="358"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="258"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="101"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS13034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="462" mass="49742" checksum="103C24061F53C98E" modified="2004-07-05" version="1">MAKKKTGDLAHRCNKCGYTQARWLGRCPECGEWNTFEEVTINQDYSAAERSIAEKFVKEAHSVPLDAIEANDAVRLSTGIAEFDRVLGGGAVKRSAILIGGEPGIGKSTLLLQAASASSSGSVKKVLYVSGEESGGQIRSRADRLNLPLKNIELLCTCRLEDVERVLNKVNPVFVIIDSIQTMYSADAGTIPGTINQLKLCAHELVSWVKERDSVLFLTAHVTKDGNIAGPKVLEHLVDTVISFERTEDDVRFLRALKNRFGSVDELGIFSMDESGLKAIDDSSSLFITNRTGPLPAGSAAVPVCEGSRVFMVEIQALTVPAKGVVTRVFSDKIDSARVSRIAAVLEKRIGLQFSDQDIYVNVAGGIRLKEPAADLAIALALYSARANIPAQKEGAYIGELSLAGEIRSVKKLKQRIKTAQSMGFTKVVSPPPSDSEAGDINTSQLFKAEDLSSAIKKVFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JY9</accession>
    <name>Q73JY9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973148.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680514.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2550"/>
    <dbReference type="EnsemblBacteria" id="AAS13067">
        <property type="protein sequence ID" value="AAS13067"/>
        <property type="gene ID" value="TDE_2550"/>
    </dbReference>
    <dbReference type="GeneID" id="2739915"/>
    <dbReference type="KEGG" id="tde:TDE_2550"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2410"/>
    <dbReference type="eggNOG" id="COG1451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065947_1_0_12"/>
    <dbReference type="OMA" id="NILARRW"/>
    <dbReference type="OrthoDB" id="1301886at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="18"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="231" mass="27103" checksum="60E3B21FC7F67A5A" modified="2004-07-05" version="1">MIIKIEGVEIEWAESKGRKLRLTISPKTAIPCIHVPKNYSQSKALDFVKENIAWIKKHQARIEEKIFKKNIKASLKDGSTVSLWGADYKIKILRAKKNASVAVDDDFIYLKEPFGADPKKRPSILNRLYKKELELYVEEILPFWEDKIKESASEIKYRDMKSKWGSCNSYTGIITLNTKLAALPCECAEMVLVHEFVHFKERLHNDRFKRYMTKYLPDWKERVKLLNSEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JZ0</accession>
    <name>Q73JZ0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_2549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973147.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680511.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2549"/>
    <dbReference type="EnsemblBacteria" id="AAS13066">
        <property type="protein sequence ID" value="AAS13066"/>
        <property type="gene ID" value="TDE_2549"/>
    </dbReference>
    <dbReference type="GeneID" id="2739914"/>
    <dbReference type="KEGG" id="tde:TDE_2549"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2409"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_12"/>
    <dbReference type="OMA" id="RFMAYEP"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="312"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="413"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS13066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="699" mass="75800" checksum="9C0B055D6F91E571" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K64</accession>
    <name>Q73K64_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen_deCOase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972957.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680278.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2358"/>
    <dbReference type="EnsemblBacteria" id="AAS12876">
        <property type="protein sequence ID" value="AAS12876"/>
        <property type="gene ID" value="TDE_2358"/>
    </dbReference>
    <dbReference type="GeneID" id="2739967"/>
    <dbReference type="KEGG" id="tde:TDE_2358"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2226"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_1_1_12"/>
    <dbReference type="OrthoDB" id="1104410at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="335" mass="38357" checksum="8EEDB507F1F04F1B" modified="2004-07-05" version="1">MKEKRKLILDAFNNKHVRRVPVGFWWHFADEYRQFRGLLDDGIIQATIDGTKKMYDDLKPDMVKIMSDGFFGHPSIMKNDINSIDDIKKIKSIGNLSPWYDKQIDMVNSILDYFDGEVAAFYNIFAPLNYIRLYTECYKKQPDLFVKLFFENPNAMLEASLEIAADLLVLADKLKGKTKLDGIYYSVQSVQSQDADLNFHQKYVSVSDKKVLDKINSLWDNNILHICGYGDYTNDLSFYKDYKAKVYNWAVNTEKVSLAEGKKFFGNACVLGGFDNNRGTLIDVGTDIEIENYVDSLIKEAGTTGVIIGADCTIAPEIGYKRLKQVRNYAEKYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KQ8</accession>
    <name>Q73KQ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972760.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668121.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2159"/>
    <dbReference type="EnsemblBacteria" id="AAS12679">
        <property type="protein sequence ID" value="AAS12679"/>
        <property type="gene ID" value="TDE_2159"/>
    </dbReference>
    <dbReference type="GeneID" id="2739145"/>
    <dbReference type="KEGG" id="tde:TDE_2159"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2040"/>
    <dbReference type="eggNOG" id="ENOG502ZBZR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093450_6_1_12"/>
    <dbReference type="OrthoDB" id="1668819at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011733">
        <property type="entry name" value="CHP02185_IM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09605">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02185">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="201" mass="21782" checksum="1B3D961385275A6E" modified="2004-07-05" version="1">MEKSNKFKTKDFVFIGIMTVVYIAVFMVIGFVTAAINPFLHAFSPAITGLVVGTIYLFLAIKVPKFGVFTISQLLLIMIVLILGMGYLPWLIGMFIGALLGDIAANTSKYKNKYTIAIASGFICLGSASGGVIPVLFFVEHYKKFCFERMQMNEAQVEQSIAASAGYLGVIILIATFVLGFAGVLIGSKILGKHFKNSGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KU1</accession>
    <name>Q73KU1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972727.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674571.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2126"/>
    <dbReference type="EnsemblBacteria" id="AAS12646">
        <property type="protein sequence ID" value="AAS12646"/>
        <property type="gene ID" value="TDE_2126"/>
    </dbReference>
    <dbReference type="GeneID" id="2739385"/>
    <dbReference type="KEGG" id="tde:TDE_2126"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2009"/>
    <dbReference type="eggNOG" id="ENOG502ZV84">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179358_0_0_12"/>
    <dbReference type="OMA" id="TEPNELH"/>
    <dbReference type="OrthoDB" id="2085026at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="76" mass="8900" checksum="0ADB7B815EDDF9B3" modified="2004-07-05" version="1">MPQISLYVKESHFEKIEKAAKNANKSISGWVLEKILPQIEPSYSNEFINLFGSVDDKTFQRPEQPKWEDDSPREFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KW2</accession>
    <name>Q73KW2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972706.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675561.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2105"/>
    <dbReference type="EnsemblBacteria" id="AAS12625">
        <property type="protein sequence ID" value="AAS12625"/>
        <property type="gene ID" value="TDE_2105"/>
    </dbReference>
    <dbReference type="GeneID" id="2740344"/>
    <dbReference type="KEGG" id="tde:TDE_2105"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1988"/>
    <dbReference type="eggNOG" id="COG3514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140900_2_0_12"/>
    <dbReference type="OrthoDB" id="1855549at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025528">
        <property type="entry name" value="BrnA_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14384">
        <property type="entry name" value="BrnA_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="92" mass="10653" checksum="B63D6A88256B1E6C" modified="2004-07-05" version="1">MNTIVTMTLDDLKKTPLTEEEKQTIRKAKSIPTDDCPKQSKEELAKFRPWYEVHQKSETSIKIDADVLEWFKAQGKGYKTKINSVLRSYAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KW4</accession>
    <name>Q73KW4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972704.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2103"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12623">
        <property type="protein sequence ID" value="AAS12623"/>
        <property type="gene ID" value="TDE_2103"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2103"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1986"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_844509_0_0_12"/>
    <dbReference type="OMA" id="ANCLESI"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="288" mass="32247" checksum="B63981B5339EDA08" modified="2004-07-05" version="1">MQQDSALLFETIIVNDGSPGTKELRRIIKTYAKRFKERGLPLVFLEHSKNLGTLEARRTATNAASGEYLTFADPDDELPPDALRILYDAACASGADIVHGSIAVFGTENEPEKRVTSFAQKAAQVYHGTLTGDEILRGFFIEHLYAAFVCGKLFQTALVQKAYGEIPFTYCTMAEDMLLYFFISLYAGKYLGIPDTVYKYRINTGLTSRRQITDLAGLQKVCSAASVFTVIFSYLDEHPDLGSDIREAVRDLGRSHYADNLKQLEICVVPSLQEEARAMLEEWWGMHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KY3</accession>
    <name>Q73KY3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA methyltransferase, TrmH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972685.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679885.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2084"/>
    <dbReference type="EnsemblBacteria" id="AAS12604">
        <property type="protein sequence ID" value="AAS12604"/>
        <property type="gene ID" value="TDE_2084"/>
    </dbReference>
    <dbReference type="GeneID" id="2741211"/>
    <dbReference type="KEGG" id="tde:TDE_2084"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1968"/>
    <dbReference type="eggNOG" id="COG0565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056931_0_1_12"/>
    <dbReference type="OMA" id="RRETINW"/>
    <dbReference type="OrthoDB" id="1637132at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
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    </dbReference>
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        <location>
            <begin position="6"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS12604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="251" mass="28205" checksum="FEE56BCCD95C4E17" modified="2004-07-05" version="1">MNFEKTIILCRPETSANIGAVCRVMANTGFSDLRITGTKEDYDETEVLKLALHASHVWKKARFYPPTIEGLKEAASDCSVLIGTSRRTGHKRKDLGMSPEDLCLDLKKFYGGRLGLVFGNERTGLIDEELNICSFSVNIPAEEDFGSYNLSHAVLILCYSLYIAEKNNPLTEKDNPSIEKNIYLQKASMKMIQENSEQICNYLSGLGLFKKGGKKTNETFFIELLSSAGASEFDIMHLTEIFKKLFFMYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KY5</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ordered locus">TDE_2082</name>
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    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972683.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12602">
        <property type="protein sequence ID" value="AAS12602"/>
        <property type="gene ID" value="TDE_2082"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3391914_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="32" mass="3774" checksum="C709B979AAD1066B" modified="2004-07-05" version="1">MQFIGLFSLTKLINCNRCFQAYLYISKAIFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KZ2</accession>
    <name>Q73KZ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GGDEF domain/EAL domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972676.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73KZ2"/>
    <dbReference type="STRING" id="243275.TDE_2075"/>
    <dbReference type="EnsemblBacteria" id="AAS12587">
        <property type="protein sequence ID" value="AAS12587"/>
        <property type="gene ID" value="TDE_2075"/>
    </dbReference>
    <dbReference type="GeneID" id="2741202"/>
    <dbReference type="KEGG" id="tde:TDE_2075"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1960"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011770_0_0_12"/>
    <dbReference type="OMA" id="IMWDLDN"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="602"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="746"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1004" mass="115495" checksum="A4CC85909E94004D" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KZ9</accession>
    <name>Q73KZ9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antigen, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972669.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679864.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2068"/>
    <dbReference type="EnsemblBacteria" id="AAS12580">
        <property type="protein sequence ID" value="AAS12580"/>
        <property type="gene ID" value="TDE_2068"/>
    </dbReference>
    <dbReference type="GeneID" id="2741195"/>
    <dbReference type="KEGG" id="tde:TDE_2068"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1953"/>
    <dbReference type="eggNOG" id="ENOG5031BZG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007801_1_0_12"/>
    <dbReference type="OrthoDB" id="1009714at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285940" evidence="1">
        <location>
            <begin position="23"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="826" mass="90901" checksum="1691194F5F2D8576" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L30</accession>
    <name>Q73L30_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glgC</name>
        <name evidence="7" type="ordered locus">TDE_2035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972638.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674820.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2035"/>
    <dbReference type="EnsemblBacteria" id="AAS12549">
        <property type="protein sequence ID" value="AAS12549"/>
        <property type="gene ID" value="TDE_2035"/>
    </dbReference>
    <dbReference type="GeneID" id="2740629"/>
    <dbReference type="KEGG" id="tde:TDE_2035"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1920"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_14_4_12"/>
    <dbReference type="OMA" id="QEWDVDE"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="424" mass="47370" checksum="EAB4F31B0D9C5DD2" modified="2004-07-05" version="1">MSKVLSIILGGGKGTRLYPLTMHRSKPAVPFGGKHRIIDIPLSNCINSGFRNIYIVTQFNSASLHIHIAKAYTFDTFSNGFVEILAAEQTFDNTGWYEGTADSIRKNLHHFRHQNPSHYLILAGDQLYRMDLKKFLNFHKESESDITVACTPVTREDASGFGIMKVNSDSLITEFMEKPGADKNIDDWKIPEKSLIKPNDPNKQYLASMGIYIFSAKIMEECLDSDHTDFGKEVIPAAINGKYKVSAFPHNGYWSDIGTIKSFYDATLDLTEITPKFDFYDAERPIYTHNRNLPPSKVNYAHLSRSICSEGCVITNSTINHSVIGVRSIIETGSFVEDSICMGADYYETHEEKETRLKEGSPGLGIGNHCRIRSAIIDKNVRIGNNVSIGMDQTPPDGDYGFYHVVGGIYVIVKNSVIPDNTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LD3</accession>
    <name>Q73LD3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4469 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972535.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679634.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12446">
        <property type="protein sequence ID" value="AAS12446"/>
        <property type="gene ID" value="TDE_1932"/>
    </dbReference>
    <dbReference type="GeneID" id="2740172"/>
    <dbReference type="KEGG" id="tde:TDE_1932"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1827"/>
    <dbReference type="HOGENOM" id="CLU_2412279_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027824">
        <property type="entry name" value="DUF4469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14734">
        <property type="entry name" value="DUF4469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4469" evidence="1">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="92" mass="9890" checksum="50DBE749C9A3A23F" modified="2004-07-05" version="1">MLKYSLKTETANIGPCIMGVSDKQNGTITIDSVMEILGSRLKFDPKDAGQGVLAVSGSKTVRCASVIENKSGRLIVLLNQVFRQADNGYITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LG0</accession>
    <name>Q73LG0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972507.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1904"/>
    <dbReference type="EnsemblBacteria" id="AAS12418">
        <property type="protein sequence ID" value="AAS12418"/>
        <property type="gene ID" value="TDE_1904"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1904"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1803"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068216_2_1_12"/>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="138" mass="16005" checksum="6CEEB6E9DF89F213" modified="2004-07-05" version="1">MNVKVININQQNQHPILKHCQTMCEYSVFVNTVRKWKGVDTQNGFQKAIEECIANNILKDYLKRKTREVLNMLLAEYDYEADIAVQRAEEREIAFAEGEERGSYQKAIETAKLMCRHNYPIAEICTMTGLSQEEIESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LM0</accession>
    <name>Q73LM0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1802</name>
        <name evidence="3" type="ordered locus">TDE_1842</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405</strain>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972406.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972446.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1802"/>
    <dbReference type="EnsemblBacteria" id="AAS12317">
        <property type="protein sequence ID" value="AAS12317"/>
        <property type="gene ID" value="TDE_1802"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12357">
        <property type="protein sequence ID" value="AAS12357"/>
        <property type="gene ID" value="TDE_1842"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1802"/>
    <dbReference type="KEGG" id="tde:TDE_1842"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1714"/>
    <dbReference type="HOGENOM" id="CLU_3259295_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="42" mass="5060" checksum="B2C197039A1E1C44" modified="2004-07-05" version="1">MRKKINFYLIILKLIKEINKIKVLQMVVVFIILGFIVKKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LM2</accession>
    <name>Q73LM2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1800</name>
        <name evidence="2" type="ordered locus">TDE_1840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405</strain>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972404.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972444.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010692225.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1800"/>
    <dbReference type="EnsemblBacteria" id="AAS12315">
        <property type="protein sequence ID" value="AAS12315"/>
        <property type="gene ID" value="TDE_1800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12355">
        <property type="protein sequence ID" value="AAS12355"/>
        <property type="gene ID" value="TDE_1840"/>
    </dbReference>
    <dbReference type="GeneID" id="2740502"/>
    <dbReference type="KEGG" id="tde:TDE_1800"/>
    <dbReference type="KEGG" id="tde:TDE_1840"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1712"/>
    <dbReference type="eggNOG" id="COG5304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171731_0_0_12"/>
    <dbReference type="OrthoDB" id="1933588at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="85" mass="9931" checksum="193D1855C4407B3D" modified="2004-07-05" version="1">MNTEKELYESIENDEWKAVKNFYDLRNDLKKAAKTMLMKKEKIDVILAKQDINNLKAKAFEEGMEYEIFAGSVLHKYLTGRLVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LM3</accession>
    <name>Q73LM3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972443.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679542.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1839"/>
    <dbReference type="EnsemblBacteria" id="AAS12354">
        <property type="protein sequence ID" value="AAS12354"/>
        <property type="gene ID" value="TDE_1839"/>
    </dbReference>
    <dbReference type="GeneID" id="2740501"/>
    <dbReference type="KEGG" id="tde:TDE_1839"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1745"/>
    <dbReference type="HOGENOM" id="CLU_087950_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="276" mass="32832" checksum="71B31C273DA4A625" modified="2004-07-05" version="1">MKNKVCFVITFVTTLIYSAYAQDKIDYLVLNKIKTVQEIIIENIKTKITVKLDENQKKEFLNNLSVVKSRDWGKCLLPYEVTIIYDDKSISFRTNGKTLGQFGTMAMYDFESDLKLLINSFFIMETEFPLYLEKTVKVKNQDIHLYQVNYSRKNLKFIQGLSSSKILDETHCRWKIGQELIDIQSSFTEKELKKHIEKENLKEVADYYIKELCKRDLFFSTYELHPLDEVNEKWIIYFVYVEKEHKGTKKYWDEVVFMLPDGTIVISENNFEEIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LN5</accession>
    <name>Q73LN5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, carbon-nitrogen family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972431.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679543.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1827"/>
    <dbReference type="EnsemblBacteria" id="AAS12342">
        <property type="protein sequence ID" value="AAS12342"/>
        <property type="gene ID" value="TDE_1827"/>
    </dbReference>
    <dbReference type="GeneID" id="2740489"/>
    <dbReference type="KEGG" id="tde:TDE_1827"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1733"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_4_12"/>
    <dbReference type="OrthoDB" id="1583074at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="295" mass="33534" checksum="59F4A767638BE018" modified="2004-07-05" version="1">MSKIIIALLQLTPGNSLVENMYIGIAACRKAKNMGADIALFPEMWSIGYEIPKSVNELKSKAISKNDAFIHSFSDLAKELQMAIGITFLEKYEPLPRNSICLFDRFGKELYTYAKVHTCIFGDEKNLMPGNDFYVSELDTERGCVKIGSMICYDREFPESARILMLKGAEILLVPNACPMEINRISQLRARAFENMVGIATVNYPKGKPDCNGHSTAFDGIAYKIDEPYSRDTLIIEAGEEEGIYIATFNIEELRKYRSREVHGNAYRQPTKYEILLSEEKQEPFIRKDYRKSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LT1</accession>
    <name>Q73LT1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972385.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957038.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1781"/>
    <dbReference type="EnsemblBacteria" id="AAS12296">
        <property type="protein sequence ID" value="AAS12296"/>
        <property type="gene ID" value="TDE_1781"/>
    </dbReference>
    <dbReference type="GeneID" id="2741225"/>
    <dbReference type="KEGG" id="tde:TDE_1781"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1696"/>
    <dbReference type="HOGENOM" id="CLU_1069352_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="260" mass="30932" checksum="DCA726E4CF653CD6" modified="2004-07-05" version="1">MKKKIIQLETNYLYYLSGVSRNPRIDITKVKSTLENFTVVISPWTFVELITTQDFTNEQKKIIVKYIINNQIGVQTFIENGKYYDFSRLINDYCYFLFSEPNKLNTFLKRVMKLKKDEEVKILNFYIIFITSFIYYLFYNKLEKLNINKNKKKCFTFCVFYLLEANNSFINRIIKKIINSHYVDFEENKTKKSLTELIGEYGYLISVIYDKVIEGSIHKLYPGFFERIYAFNDLTVNDGASSTSKQFIRLLNKFTSAKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M15</accession>
    <name>Q73M15_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972300.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957021.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1696"/>
    <dbReference type="EnsemblBacteria" id="AAS12211">
        <property type="protein sequence ID" value="AAS12211"/>
        <property type="gene ID" value="TDE_1696"/>
    </dbReference>
    <dbReference type="GeneID" id="2740868"/>
    <dbReference type="KEGG" id="tde:TDE_1696"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1622"/>
    <dbReference type="eggNOG" id="COG5476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028172_2_0_12"/>
    <dbReference type="OMA" id="FKEFPHT"/>
    <dbReference type="OrthoDB" id="421877at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009197">
        <property type="entry name" value="MlrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010799">
        <property type="entry name" value="MlrC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015995">
        <property type="entry name" value="MlrC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07364">
        <property type="entry name" value="DUF1485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07171">
        <property type="entry name" value="MlrC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012702">
        <property type="entry name" value="UCP012702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1485" evidence="2">
        <location>
            <begin position="3"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="MlrC_C" evidence="1">
        <location>
            <begin position="306"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="493" mass="54032" checksum="181DE0B60E2C071B" modified="2004-07-05" version="1">MKRILVGCINHESNSFNPIITGIEDFVIFRGEDVLTEGLKPYYSSTGIIETIQKWGWEVVPAVVARAVPNGLVDYNLYTELKKDFLAYIDKALLDAPIDGICLGLHGSLKVQNIGPAEGDLLKAIREKLPRIPLTTALDMHATVTDEMIRYCDGIVGYKTAPHIDCYETGVHAAELLKKALDASNKLCIGRVKIPMLVAGEKSETAAEPMKSLIASCVEAEKEEGLLAASVLLGFPWADSKDNGVTIVTTALNDQGLADRAALKIAKEFWAERHNFKFKVEHYDSFTSIKTAIESVMQNKEGPVFVSDSGDNPTAGSTGDSTECFEALLKQKEALKDLPTKVLYSGFFDKVAVEKCFEAGEGASLEITIGGTWDKINGKKIPCAVRVLKLVENYGVYNSRLALVEMGETIIVLTSNHIGFGDEELLPALDVNAEDYCIVIVKLGYLEPCFQKIAKRAILAESKGCSNEVLETLDYPQTPRPIYPLDKDMDIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M21</accession>
    <name>Q73M21_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972294.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1690"/>
    <dbReference type="EnsemblBacteria" id="AAS12205">
        <property type="protein sequence ID" value="AAS12205"/>
        <property type="gene ID" value="TDE_1690"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1690"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1617"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1288410_0_0_12"/>
    <dbReference type="OMA" id="ADRISNM"/>
    <dbReference type="OrthoDB" id="1405426at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="41"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="205" mass="23529" checksum="BFF625CFF2B839DF" modified="2004-07-05" version="1">MLSFDSNKEFALTRDLGVLKGIYLAPYMQVATALIGKARHAGGNMFRHQVDTMAILIDYGYIDSVLLKASLIHDVIEDIEDFNVNEILSIDSESGQVYELVLEVTKKKGQEKTEYLKNIIKNGSEKAKILKCADRISNMISLGFVTDSEFIERYCNETELYIFPIALEVNFEMYKELMALVVSRRQYLVECGYLEERVKKMRKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M36</accession>
    <name>Q73M36_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972279.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670987.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1674"/>
    <dbReference type="EnsemblBacteria" id="AAS12190">
        <property type="protein sequence ID" value="AAS12190"/>
        <property type="gene ID" value="TDE_1674"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1674"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1600"/>
    <dbReference type="eggNOG" id="ENOG5031DHK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2095814_0_0_12"/>
    <dbReference type="OrthoDB" id="2190095at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="119" mass="13864" checksum="C07731077B3633DB" modified="2004-07-05" version="1">MDSKDIQPQPRYKRFTIRFLDRSIRFLSASIFAFIIFYILSSSQDFLDSSLFIILNVLMSLCVLLIIFTFAAIAVRIFFMIRYKEINIIKFITDIFLLFLSIILAVLFSFLVVVAKGNV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M38</accession>
    <name>CLPP1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease proteolytic subunit 1</fullName>
            <ecNumber evidence="1">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endopeptidase Clp 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpP1</name>
        <name type="ordered locus">TDE_1672</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972277.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679367.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M38"/>
    <dbReference type="SMR" id="Q73M38"/>
    <dbReference type="STRING" id="243275.TDE_1672"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="PRIDE" id="Q73M38"/>
    <dbReference type="EnsemblBacteria" id="AAS12188">
        <property type="protein sequence ID" value="AAS12188"/>
        <property type="gene ID" value="TDE_1672"/>
    </dbReference>
    <dbReference type="GeneID" id="2740127"/>
    <dbReference type="KEGG" id="tde:TDE_1672"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1598"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_12"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <feature type="chain" id="PRO_0000179702" description="ATP-dependent Clp protease proteolytic subunit 1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <sequence length="197" mass="21751" checksum="88A2675C0D4CC417" modified="2004-07-05" version="1">MSTLVPYVIEQTGNGERSYDIFSRLLKDRIIFVDGEINDMSADLVVAQLLFLEAQNPDKDISLYINSPGGSVTAGLAIYDTMQHIRPDVQTICLGQCASMGAVLLAGGAKNKRYALPSSRVMIHQPWGGVQGQAVDINIQAKEIVRLKKLTIKYFAENTGKTEKQVAADMERDFFMSAEEALTYGIIDTVMNRRKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M47</accession>
    <name>Q73M47_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972268.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671003.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1663"/>
    <dbReference type="EnsemblBacteria" id="AAS12179">
        <property type="protein sequence ID" value="AAS12179"/>
        <property type="gene ID" value="TDE_1663"/>
    </dbReference>
    <dbReference type="GeneID" id="2739004"/>
    <dbReference type="KEGG" id="tde:TDE_1663"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1590"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1585739_0_0_12"/>
    <dbReference type="OrthoDB" id="1687246at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285833" evidence="3">
        <location>
            <begin position="22"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="51"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="167" mass="19229" checksum="81994031D698CDB3" modified="2004-07-05" version="1">MKKVRVLLLLLSVLFMFSCKSAPKQKEEKPAEPEKTQEQEVVKEETDKKANEKNMSDDYYTVYFAPQSYQIDQFTAQILKEIGEDLKAKNVKKIVIYGHSAKLDSQKDEDRIALQRAIAVASYFQKMKLFDANNIIVEGKGASEPARSHSEITDRFKNRRVEIHSVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MB8</accession>
    <name>NADK_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD kinase</fullName>
            <ecNumber evidence="1">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadK</name>
        <name type="ordered locus">TDE_1591</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972197.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679270.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MB8"/>
    <dbReference type="SMR" id="Q73MB8"/>
    <dbReference type="STRING" id="243275.TDE_1591"/>
    <dbReference type="EnsemblBacteria" id="AAS12108">
        <property type="protein sequence ID" value="AAS12108"/>
        <property type="gene ID" value="TDE_1591"/>
    </dbReference>
    <dbReference type="GeneID" id="2739788"/>
    <dbReference type="KEGG" id="tde:TDE_1591"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1521"/>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_0_12"/>
    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="OrthoDB" id="1463423at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
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        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
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        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000229709" description="NAD kinase">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="60"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <sequence length="284" mass="30737" checksum="CBB8D218AA802ADC" modified="2004-07-05" version="1">MKKVLIVLSIEKPNAKKICKEIEAFLSAKGIDSFVYKYDGISHSPELNEDYDLAISLGGDGTVLFTARYSAPRHIPVFPINLGRFGFIANIEPKEWEGELLHLLNGKQALHKRMLLSASINRKNKEIVKYEALNDAVVSGSGIAKLINLDISFNGISFGVFRADGVIVSTPTGSTAYSAASGGPILDPDVSAFVLTPISPFSLSNRPLVLPSSGQMKIKILPARAKDIIVSIDGQEMVSLQEDDEIIISESPNKVKMAGCSPDNFYKALRSKLGWSGSSSPKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MF6</accession>
    <name>Q73MF6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972158.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679212.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1552"/>
    <dbReference type="EnsemblBacteria" id="AAS12069">
        <property type="protein sequence ID" value="AAS12069"/>
        <property type="gene ID" value="TDE_1552"/>
    </dbReference>
    <dbReference type="GeneID" id="2739302"/>
    <dbReference type="KEGG" id="tde:TDE_1552"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1488"/>
    <dbReference type="eggNOG" id="ENOG5031D86">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1408183_0_0_12"/>
    <dbReference type="OrthoDB" id="1875252at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005700862" evidence="2">
        <location>
            <begin position="21"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="193" mass="22378" checksum="2179DFD68B908361" modified="2004-07-05" version="1">MKKLSIKPFLCLLFSVLIFTSGCSSVWSKKYKDDAGVMYGMIYDGNEEGVSGVNVKVNGGLKAVSDGQGRFILKFLYADIKDKKEQRIELEKEGYEKIEEVFYYEPMSLLHIRMESGEDILKEAESLIDEKEYRRAEESIDRVIKIEEYRDEGLFLKAVIKYKEGKKEEAAELLEKLKEKDNESIKSFLRKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MJ3</accession>
    <name>Q73MJ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_1515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972121.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1515"/>
    <dbReference type="TCDB" id="3.A.1.122.8">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12032">
        <property type="protein sequence ID" value="AAS12032"/>
        <property type="gene ID" value="TDE_1515"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1515"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1454"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_4_12"/>
    <dbReference type="OMA" id="TLCVNTT"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="18"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="277"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="373" mass="41075" checksum="6EE6B44F91E4F97B" modified="2004-07-05" version="1">MYFKMIMSSLLRRRSRMLVALMAIAIGSTVLSGLLTIYYDIPRQMGTVFRSYGANMIFLPSESDAKIKKEQIDKIKKEIDSGKLVGFAPYIYKPAKVNEQPYMIAATDLISAKNNSPYWLVRGQWPDKKKEVLIGHEISKAIGLSIGDNFIVNTPKPDGDVTVNEFKVSGIVTTGGVEEEFIFMSLEDIKNIVGYNDAFDVIECSIDGNRDYLNLIAEKVSNDVKGITPRLVKRVTESQDTVLSKLQALVWIVTIIVLFLTMICVTTTMMAVVVERRKEIGLKKALGASNKSVVIDFLGEAVMLGLMGGILGIGLGYLFANNVSISVFAREVSFPIRLAPFTVISSIVITIVASLFPVRATVDVDPALVLRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MK3</accession>
    <name>Q73MK3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972111.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671223.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1505"/>
    <dbReference type="EnsemblBacteria" id="AAS12022">
        <property type="protein sequence ID" value="AAS12022"/>
        <property type="gene ID" value="TDE_1505"/>
    </dbReference>
    <dbReference type="GeneID" id="2739711"/>
    <dbReference type="KEGG" id="tde:TDE_1505"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1444"/>
    <dbReference type="eggNOG" id="COG1585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116732_1_1_12"/>
    <dbReference type="OMA" id="ICRDNIA"/>
    <dbReference type="OrthoDB" id="1951939at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="3">
        <location>
            <begin position="55"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="147" mass="16759" checksum="EF79E672F3822E98" modified="2004-07-05" version="1">MGWWSIWLLVGVLCIGLELIIPGLVIIFFGFGAVFTSVFSLIPFINQALWLQIIIFVIFSVLSLAFLRKKFTPIFKGTIFYSDKKSDKEGEEFADVIETVFHNKEGRIKYQGTTWSARSLSEEIPAGSMVRVLRREGLTYIVEKAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MS5</accession>
    <name>Q73MS5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972038.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671344.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1432"/>
    <dbReference type="EnsemblBacteria" id="AAS11949">
        <property type="protein sequence ID" value="AAS11949"/>
        <property type="gene ID" value="TDE_1432"/>
    </dbReference>
    <dbReference type="GeneID" id="2739709"/>
    <dbReference type="KEGG" id="tde:TDE_1432"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1373"/>
    <dbReference type="eggNOG" id="ENOG5030KXI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047564_0_0_12"/>
    <dbReference type="OrthoDB" id="1408633at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="439" mass="51795" checksum="183F88B092BC4AE7" modified="2004-07-05" version="1">MPKIITCTGYGTTGSSAVTNIIEEFESVKSLSAEFECSFLHEPDGIRDLESALHEGHRLKSDLAIKRFLRLADVLNKQRSFKKYFNGNFLRHSKSFIDSICIAQWQGNWHRGTDTIKLSKEDLLYYNLAKQVFLNEYSYSRYSLFEPNSWHPAYHMRNKSYYAHFTDLFYLKAQEYIGKLIAEIEVHVDGEKILIDQFFPAYDISAYLNYAPDTKVIIVDRDPRDMYVLNKSSWGESYIPTDDVDTFIRWYRGIRFSQQQEVQNKNVLLLHFEDLIFNYETSLDEIKCFLNFTDKDHIKKLKCFNPAQSIKNTYKFKNYPQWKDDVLKIEYELSEYCYHFPDDFIDSKEINVDTNKPIEDCIKSADAVQSKKNLPLKYNHKLPVFLFGITNFGEAFESLAHRNTLKTKIKGLIKCGVFLCSFLFEYMYSVFIYCKYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MT3</accession>
    <name>Q73MT3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FdtA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972030.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679039.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1424"/>
    <dbReference type="EnsemblBacteria" id="AAS11941">
        <property type="protein sequence ID" value="AAS11941"/>
        <property type="gene ID" value="TDE_1424"/>
    </dbReference>
    <dbReference type="GeneID" id="2739701"/>
    <dbReference type="KEGG" id="tde:TDE_1424"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1365"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127501_0_0_12"/>
    <dbReference type="OMA" id="KRVYYIF"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd20292">
        <property type="entry name" value="cupin_QdtA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008894">
        <property type="entry name" value="QdtA_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05523">
        <property type="entry name" value="FdtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FdtA" evidence="1">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="138" mass="15837" checksum="4E316F254E6F3450" modified="2004-07-05" version="1">MIYSTADSKIIDLISQNNITHLNHKSVVPFEVKRIYYLYGVPENQERGAHAHKELFQLLLAASGSFNVELDDGKNKKKIFLNSTSKGLLIVPGIWRNLTNFSFGSVALVLASEYYTETDYIRNYDEFLKYRKINELGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MX0</accession>
    <name>Q73MX0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971992.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678969.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1386"/>
    <dbReference type="EnsemblBacteria" id="AAS11903">
        <property type="protein sequence ID" value="AAS11903"/>
        <property type="gene ID" value="TDE_1386"/>
    </dbReference>
    <dbReference type="GeneID" id="2741147"/>
    <dbReference type="KEGG" id="tde:TDE_1386"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1328"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_18_12"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="325"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="611" mass="66646" checksum="4A5794488DE714DE" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N23</accession>
    <name>Q73N23_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HflC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">HflC and HflK could regulate a protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the band 7/mec-2 family. HflC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971939.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678885.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1333"/>
    <dbReference type="MEROPS" id="I87.001"/>
    <dbReference type="EnsemblBacteria" id="AAS11850">
        <property type="protein sequence ID" value="AAS11850"/>
        <property type="gene ID" value="TDE_1333"/>
    </dbReference>
    <dbReference type="GeneID" id="2741067"/>
    <dbReference type="KEGG" id="tde:TDE_1333"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1281"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059167_1_1_12"/>
    <dbReference type="OMA" id="DFFAFYR"/>
    <dbReference type="OrthoDB" id="1714999at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052547">
        <property type="term" value="P:regulation of peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03405">
        <property type="entry name" value="SPFH_HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010200">
        <property type="entry name" value="HflC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911">
        <property type="entry name" value="PTHR42911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005651">
        <property type="entry name" value="HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01932">
        <property type="entry name" value="hflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="5">
        <location>
            <begin position="55"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="354" mass="40589" checksum="9B206747989609D6" modified="2004-07-05" version="1">MENYENTENGNTEDVRFESPSSKNKIKPEKNKKDKKGFGLFFFVVILLVLFFFLKPFYILNEGNVAIITKFGAVVKTEKEAGLHFKMPLIHTVNKYTAKLLRLDGDPQKILTLEKQYLKVDTTSRWRIVDVKKFYESLTTYDSAYSRLSDIVDSSVRDIISVNSLADVVRSSNIINESKKTEEFNLENAEVDLGSLKTEKVNFPVIKKGRETLADEILAKANSQLGEFGLEVVDLIFKGIKYSDELENSVFSRMIKERNQIAGTFRSTGDGEKLKILGELENEKRTILSQAYAESERIKGDADAKAVAIYAESYGKSPEFYSFWKSMEIYKNSLPETEKVLSTDMEYFQYLYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N65</accession>
    <name>Q73N65_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971897.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1290"/>
    <dbReference type="EnsemblBacteria" id="AAS11808">
        <property type="protein sequence ID" value="AAS11808"/>
        <property type="gene ID" value="TDE_1290"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1290"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1239"/>
    <dbReference type="eggNOG" id="ENOG5032GX8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_726952_0_0_12"/>
    <dbReference type="OrthoDB" id="1469729at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="389" mass="45073" checksum="7EB46A14C3A7B2D7" modified="2004-07-05" version="1">MFLFISCFSDNTKQEFPKEAKACADYVLQNYMTPESYVIEKFKDHDAVILGENHRIKHDPLLVQRLIPLLYENGIYTVAIEFALYEDQPLIDALVTASEYDEKLAQKINLNAFLSIGLGGYHEYCDIFKAAWKLNASLPPDSKKMRILGINDVLDWSLQKTKADRNNPEIRKKIFRNFSEKNWAYRVKTEVLDRGEKVLCYCGMHHAFSKYRQPIADESLGAFIRFGDIRFGNYLYEKIKDKVFTISLHYPWVSAQGYKAPSVLPVDGIIDYAMALLPKENRHFGVDTASSPFGLLTSQTSYYKYGYEPFMLKDFCDGYICQGPFTEYEGVTPIKDFINEDNIEYAKEHLWYPINQWPIQEINEGNASDAQIKRHHLKSIIEAVKDLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N89</accession>
    <name>Q73N89_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">purM</name>
        <name evidence="16" type="ordered locus">TDE_1266</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971873.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678769.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1266"/>
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        <property type="protein sequence ID" value="AAS11784"/>
        <property type="gene ID" value="TDE_1266"/>
    </dbReference>
    <dbReference type="GeneID" id="2740559"/>
    <dbReference type="KEGG" id="tde:TDE_1266"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1217"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_12"/>
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    <dbReference type="OrthoDB" id="923547at2"/>
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        <property type="reaction ID" value="UER00129"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
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        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="14">
        <location>
            <begin position="81"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="15">
        <location>
            <begin position="196"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AAS11784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="366" mass="39382" checksum="52642F5949076438" modified="2004-07-05" version="1">MNEMKNKNQEQPKGKSEDLSKDKSSVYSASGVNIDAGNEAVRLMSAAVRSTFNKSVLSDVGTFGGLFGTEELFKMKKPVLVGSTDGVGTKVKIAAEAGRYTTIGQDIVNHCIDDILVQGAKPLFFLDYVASSKLDPQMIADIVGGMAKACKESGCALIGGETAEMPGVYMEGEFDIAGTIVGAVDEEKILPKKNIKEGDLLIGLASDSPHTNGYSLIRTAFKGVDLNTVYPELKAPLHEVLLKPHRSYLNAIYPTLQEHPEIVKALAHITGGGFIENIPRVIPAGLVIKVKKGSWPVPPLYPLIQKLTGASGDEMYRVFNMGIGMIAVVSPDMAEKYRELVGEESWIIGKLEKAGNQTQKAVTILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NA1</accession>
    <name>Q73NA1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Smr domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971861.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678761.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1254"/>
    <dbReference type="EnsemblBacteria" id="AAS11772">
        <property type="protein sequence ID" value="AAS11772"/>
        <property type="gene ID" value="TDE_1254"/>
    </dbReference>
    <dbReference type="GeneID" id="2741430"/>
    <dbReference type="KEGG" id="tde:TDE_1254"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1206"/>
    <dbReference type="eggNOG" id="COG2840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055978_3_0_12"/>
    <dbReference type="OMA" id="ILEAWES"/>
    <dbReference type="OrthoDB" id="1888882at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="90"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="170" mass="19438" checksum="9A29EB2307D04319" modified="2004-07-05" version="1">MSKNFGDILDEWDKITGKPYGKKQIKKDEHLNKKNHKTLIKEDNSKKINPMEMWLRRYGVEDKDAQEEFTSVDYARQRKTLREMHCEDEIDLHGMTCDEAEAALNVFFENSIRRGLKKILIIHGKGNHSGGGAVLAPFVRSYLEKHKRAGECGHPKNADGGTGSTWVILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NE1</accession>
    <name>Q73NE1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal-body rod protein FlgC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">flgC</name>
        <name evidence="8" type="ordered locus">TDE_1213</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4 5">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971820.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671661.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1213"/>
    <dbReference type="EnsemblBacteria" id="AAS11731">
        <property type="protein sequence ID" value="AAS11731"/>
        <property type="gene ID" value="TDE_1213"/>
    </dbReference>
    <dbReference type="GeneID" id="2740107"/>
    <dbReference type="KEGG" id="tde:TDE_1213"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1168"/>
    <dbReference type="eggNOG" id="COG1558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123272_0_0_12"/>
    <dbReference type="OMA" id="YVAYPNI"/>
    <dbReference type="OrthoDB" id="1870921at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006299">
        <property type="entry name" value="FlgC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01395">
        <property type="entry name" value="FlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="7">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="151" mass="16576" checksum="6168DD2C65CCD875" modified="2004-07-05" version="1">MGLFTSINIAATGMGVERLRTDVISNNIANASSLETQEGGPFKRSRVIVGQKKSGIDWQTPFTPQNVERGVGEGVKVLSIEKDTSDTRWVYDPTHPKALKYGPKEGYVEYPNVNIVTEMVDLISASRAYEANLAVVNGAKDMFQRALDIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NH4</accession>
    <name>Q73NH4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron compound ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971786.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670725.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1178"/>
    <dbReference type="EnsemblBacteria" id="AAS11697">
        <property type="protein sequence ID" value="AAS11697"/>
        <property type="gene ID" value="TDE_1178"/>
    </dbReference>
    <dbReference type="GeneID" id="2740075"/>
    <dbReference type="KEGG" id="tde:TDE_1178"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1136"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_12"/>
    <dbReference type="OMA" id="FHIDAEI"/>
    <dbReference type="OrthoDB" id="1048863at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="262" mass="29890" checksum="AE2EDD88F89771EE" modified="2004-07-05" version="1">MTAVSAKDISLRYDKKDVVKSFSADFTQGKIISIIGPNGSGKSTILRSFARLLNTACGQISLFDTDIATVSKKEFAKRLAILLQHNISPEDITVKNLIYFGRCPHKKWYQQFEKRDEDILQQVLIQTDLVDFAEKKVCMLSGGERQRVWLAMALAQQPQVLLLDEPTTYLDIGYQLELLDLVYDLNRNTNLSIIMVLHDLNQAAQYSDEIIVLKDGKLYKKGTPQEIFTSELIKQIYGIDCKVIYDEEEHFPIVLPKRKGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NJ1</accession>
    <name>Q73NJ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971769.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956907.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1161"/>
    <dbReference type="EnsemblBacteria" id="AAS11650">
        <property type="protein sequence ID" value="AAS11650"/>
        <property type="gene ID" value="TDE_1161"/>
    </dbReference>
    <dbReference type="GeneID" id="2741493"/>
    <dbReference type="KEGG" id="tde:TDE_1161"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1120"/>
    <dbReference type="HOGENOM" id="CLU_2703741_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="73" mass="8771" checksum="5205350F847A01FF" modified="2004-07-05" version="1">MGEPFMITNLFIIISGARIFLLQKILELLPELVKARYKEFLQLYHSPILFTKRVTENTHYLKTRIYKWQTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NK7</accession>
    <name>Q73NK7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971753.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956892.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1145"/>
    <dbReference type="EnsemblBacteria" id="AAS11634">
        <property type="protein sequence ID" value="AAS11634"/>
        <property type="gene ID" value="TDE_1145"/>
    </dbReference>
    <dbReference type="GeneID" id="2740004"/>
    <dbReference type="KEGG" id="tde:TDE_1145"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1104"/>
    <dbReference type="eggNOG" id="ENOG502Z8BQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423316_0_0_12"/>
    <dbReference type="OMA" id="GTEANEW"/>
    <dbReference type="OrthoDB" id="223280at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="647" mass="73443" checksum="843CDEC55BB083CC" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NK8</accession>
    <name>Q73NK8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971752.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956891.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1144"/>
    <dbReference type="EnsemblBacteria" id="AAS11633">
        <property type="protein sequence ID" value="AAS11633"/>
        <property type="gene ID" value="TDE_1144"/>
    </dbReference>
    <dbReference type="GeneID" id="2740003"/>
    <dbReference type="KEGG" id="tde:TDE_1144"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1103"/>
    <dbReference type="HOGENOM" id="CLU_828857_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="335" mass="37447" checksum="5BE67C5B7A948D07" modified="2004-07-05" version="1">MGLLMGLGLAFGALGAGFNIFQGWNRSQQEQAEIRARQEEERRMREAQIAEQRAAAEREINYAKSVFKIEQEDAFRKADDIWHQGERIDMRADLDETLTGRAFNLAIKQSNAQDESLLHQEQRGKQNFQNTQGAFKAALGTSGVRAGANSSEGLLSQNEENFNQDLALMKKQRETQKEISLMSAFSNLKGGMFRIDEERDAANKAFRDSKQLRDDYSEGGRAVNLFNQKIANRRADLQGSINLQNLGGEFKQQAMQRAYDRAAYSFLDGLTDLFGGFGSGFNFGSNIAGFAKNWGGGSFGGRAGNFGSTAAALANYKRDFSDYKRKYRGPYMNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NL3</accession>
    <name>Q73NL3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971747.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1139"/>
    <dbReference type="EnsemblBacteria" id="AAS11628">
        <property type="protein sequence ID" value="AAS11628"/>
        <property type="gene ID" value="TDE_1139"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1139"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1098"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787405_0_0_12"/>
    <dbReference type="OrthoDB" id="2109623at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="352" mass="39598" checksum="8AECE38944B2EDD8" modified="2004-07-05" version="1">MPIAGNRNELTISLWRQWDGVVEADAYRGVFATANIKAYFDQTTDFLTIELAEVKTVTDIKDDQEQAHWCFLFSKNSFFKVYKNAELKAEVTAGNYPVDFSEGFTLGGGRTHATFDEVRMYKAVVTESEIRGLYRLVTKGTQVQQLKNIVTEATPKYLGVVETVPDTKTAIITKGERLGAVDANSGDWVLSGRTIGGWKVGVCYKWSGAQWLNLEPEVNYAKEYQSCLVHMFQIEELKQQTGHFGALFAKVLVAQKAMIDELLVNQAFIKNLVVQKLKIDTDDTTNQDFEAWFDELNGLKIRNKGEEIFKIDTNGDIYIKGATVTANKLIAPTLTEDPQNAVFGEIWFRKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NP2</accession>
    <name>Q73NP2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971718.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682414.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1110"/>
    <dbReference type="EnsemblBacteria" id="AAS11599">
        <property type="protein sequence ID" value="AAS11599"/>
        <property type="gene ID" value="TDE_1110"/>
    </dbReference>
    <dbReference type="GeneID" id="2739526"/>
    <dbReference type="KEGG" id="tde:TDE_1110"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1070"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_618116_0_0_12"/>
    <dbReference type="OMA" id="DEAHIRS"/>
    <dbReference type="OrthoDB" id="1942815at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="439" mass="49472" checksum="E978AD82B7C0412B" modified="2004-07-05" version="1">MLKTLYKITALVIFSFFVFSCSEKEEQVGVENKEAQSEVGSQAGLNSEKKDNGLQSGQDKTKTADAQYQKALNEASVIFEFEAVNKKINLSLKADENIKIEGAVPSEIPADGSVNEIFIAKNSLALLGDVKELTIHNAEILSGVKIIKAPALKSLDISFSGLKNIEFIDCKALENLILEGNKKMNKPDFSSLKGLKKLNLAKTTIREMDFSVFPRLECLDISSISLKKLDLTKNIELKELDCENSGLNTLDLTKNIKLQRLNCRANKLTDLALFQNKELKFLDCGKNNLDKLLIALNTKLQKLYCDSNEIKDLDLPSLKELEELYCYRNKIENLVVGSNRKLKNLFCFENKINEKSMKQLFDSLIAGDGYDIKTLVVYAEKNPNLTYKADKYFDHNFVPTEEMLNSSSFKFWKVYFTLYGLEDMGSIIDSLVQKTGEAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NR8</accession>
    <name>Q73NR8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Folylpolyglutamate synthetase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971692.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682395.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1084"/>
    <dbReference type="EnsemblBacteria" id="AAS11573">
        <property type="protein sequence ID" value="AAS11573"/>
        <property type="gene ID" value="TDE_1084"/>
    </dbReference>
    <dbReference type="GeneID" id="2739096"/>
    <dbReference type="KEGG" id="tde:TDE_1084"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1043"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_2_12"/>
    <dbReference type="OMA" id="DKDYHEM"/>
    <dbReference type="OrthoDB" id="1232874at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="4">
        <location>
            <begin position="135"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="450" mass="50546" checksum="F0002B35F4A53090" modified="2004-07-05" version="1">MNTEEFSKWLDAFINYERNAHKDENNLKKMRKFADFFGNPQDDFLSIHIAGSKGKGSVSTMIASILKEAGKKTGLYTSPHVSDFRERMTQAGSFFDDEAYSASYKKIVEGFGAILKKEPEIDPGWFEIVTVTAFLLFSMQKTDWAVIETGMGGRLDMTNILKPRACVLTPIELEHTQYLGDTLEKIAFEKAGIIKENTPVFCCKQPDGVLAVFKKRAAELNAEFFYILDIVKEPVNYSLSKAGLKIDMEFKNSHYLSKLFKRPISSNLKLLDLIQAENAVLAACTVKYLFPEMDEALIERGLASAWLPARFELLSDNPEIIIDGAHTKNSIALCMSTYTELVKEKGTLIFACAEDKNVRDMVPFFKDNFTKIIVTIPGASKKSNPDLSYTIFQEGLKASSCMVEKNADYEAVIKNEIIECREKKQPLLITGSFYLAAEAKRIHSLLSPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NS4</accession>
    <name>Q73NS4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971686.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682387.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1078"/>
    <dbReference type="EnsemblBacteria" id="AAS11567">
        <property type="protein sequence ID" value="AAS11567"/>
        <property type="gene ID" value="TDE_1078"/>
    </dbReference>
    <dbReference type="GeneID" id="2739090"/>
    <dbReference type="KEGG" id="tde:TDE_1078"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1038"/>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017490_1_0_12"/>
    <dbReference type="OMA" id="HVKNNIH"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="265"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="408" mass="46480" checksum="1B3C9440B467FB85" modified="2004-07-05" version="1">MEAKKLTERVYCIHADIHDRTARFEGIWLLPHGVSINSYVVKGEKTALIDIVKDWDGSVDSYRKQLESIGLSFSSFDYVILNHLEPDHADLINLVKEENPRAEILASSKGVALIKNFFKINEGVRAVKDGEVLDLGGGKKLVFYETPNIHWPETMMTYDPDDKILFSCDAFGSYGCIGEKIFDDQHTEDELKFFENEALRYYANIVASFSSFVNKGIEKLAALELKFICPSHGLLWRGNPSRIVNLYKKFADYNTGTGSGLEKTICIIWGSMYGYTKAGLDAVIEGIDEEGVPYSIYRIPDTDATFILGEAYRSAGLLLAMPTYEYKMFPPMAHILDLFERKHFVNKKVFRIGSWGWVGGAKKEYEEKIEKFKWTNIESHEWQGKLSDEDKRILKERGRELARAVKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NT0</accession>
    <name>Q73NT0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971680.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956874.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1072"/>
    <dbReference type="TCDB" id="3.A.1.5.47">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11561">
        <property type="protein sequence ID" value="AAS11561"/>
        <property type="gene ID" value="TDE_1072"/>
    </dbReference>
    <dbReference type="GeneID" id="2740833"/>
    <dbReference type="KEGG" id="tde:TDE_1072"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1032"/>
    <dbReference type="eggNOG" id="COG3889">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010991_1_0_12"/>
    <dbReference type="OMA" id="YNDTRYE"/>
    <dbReference type="OrthoDB" id="63045at2"/>
    <dbReference type="BRENDA" id="7.4.2.9">
        <property type="organism ID" value="6426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285867" evidence="1">
        <location>
            <begin position="23"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="39"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="871" mass="95556" checksum="F082AA2A62072DCA" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NV6</accession>
    <name>Q73NV6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971654.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1046"/>
    <dbReference type="EnsemblBacteria" id="AAS11535">
        <property type="protein sequence ID" value="AAS11535"/>
        <property type="gene ID" value="TDE_1046"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1046"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1006"/>
    <dbReference type="eggNOG" id="ENOG5032ZJK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138593_0_0_12"/>
    <dbReference type="OMA" id="CPIHCYK"/>
    <dbReference type="OrthoDB" id="1870180at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020483">
        <property type="entry name" value="Uncharacterised_YgbA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11756">
        <property type="entry name" value="YgbA_NO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="116" mass="14099" checksum="FC322228DE9DAA09" modified="2004-07-05" version="1">MNKDKKEQEKKLIAIMIDMYRSFKGREMSDEELDELFLYASKRIETCIYRRNDEKKPFCNVCPVHCYKSDMREKIRKVMRYAGPRLLFKRPILSLKHLFKTIYAKKHHPKPPGRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P21</accession>
    <name>Q73P21_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971588.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73P21"/>
    <dbReference type="STRING" id="243275.TDE_0978"/>
    <dbReference type="EnsemblBacteria" id="AAS11469">
        <property type="protein sequence ID" value="AAS11469"/>
        <property type="gene ID" value="TDE_0978"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0978"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.940"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1668633_0_0_12"/>
    <dbReference type="OrthoDB" id="956253at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="158" mass="17288" checksum="0882327403CF86CA" modified="2004-07-05" version="1">MEENSFRDIDALTSVTLPDGLKDIDRYVFYGCPNLVTLNLPSSLKYIGGISIRGLKVSSMVVPENIKVLNWYVLSNCPELTSVELPSTLTIMDFYVLSSDPKLKTVTCKAANPPAITAGQHVFENTPIASARLRVPAGSKALYQAAEGWKDFGTIVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P57</accession>
    <name>Q73P57_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Long-chain-fatty-acid--CoA ligase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971552.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682243.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0942"/>
    <dbReference type="EnsemblBacteria" id="AAS11433">
        <property type="protein sequence ID" value="AAS11433"/>
        <property type="gene ID" value="TDE_0942"/>
    </dbReference>
    <dbReference type="GeneID" id="2740975"/>
    <dbReference type="KEGG" id="tde:TDE_0942"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.908"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_9_12"/>
    <dbReference type="OMA" id="WLMQRAF"/>
    <dbReference type="OrthoDB" id="164380at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="575" mass="64081" checksum="FD7C07816A22EDC9" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P90</accession>
    <name>Q73P90_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II DNA modification methyltransferase M.TdeIII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tdeIIIM</name>
        <name evidence="4" type="ordered locus">TDE_0909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971519.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682204.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0909"/>
    <dbReference type="REBASE" id="6314">
        <property type="entry name" value="M.TdeIII"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11400">
        <property type="protein sequence ID" value="AAS11400"/>
        <property type="gene ID" value="TDE_0909"/>
    </dbReference>
    <dbReference type="GeneID" id="2739949"/>
    <dbReference type="KEGG" id="tde:TDE_0909"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.880"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039482_0_0_12"/>
    <dbReference type="OMA" id="KHGKICK"/>
    <dbReference type="OrthoDB" id="1071106at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001091">
        <property type="entry name" value="RM_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00508">
        <property type="entry name" value="S21N4MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="3">
        <location>
            <begin position="71"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="535" mass="62118" checksum="D85BC403BFA0D537" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P99</accession>
    <name>Q73P99_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971510.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677302.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0900"/>
    <dbReference type="EnsemblBacteria" id="AAS11391">
        <property type="protein sequence ID" value="AAS11391"/>
        <property type="gene ID" value="TDE_0900"/>
    </dbReference>
    <dbReference type="GeneID" id="2739940"/>
    <dbReference type="KEGG" id="tde:TDE_0900"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.871"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_12"/>
    <dbReference type="OMA" id="AMAMSCK"/>
    <dbReference type="OrthoDB" id="870493at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="262"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="294"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="474" mass="53548" checksum="C81305DD13F8DDCA" modified="2004-07-05" version="1">MAVELQNYSFSYDGRTQILNNINIKVNQGEFVVITGLSGCGKTTLIRVLNGLCPHFYSGTVQGRYELYGKDAKNMSIGELSKYWGSVFQDPRSQFLARKVKDELVIAMENACEDRVLMKNKLEEAARELEIEKILDTDMMYLSSGEKQKVAIGSVFCTQPKGFVLDEPSANLDSAATSGLAEFLKRVKEKGCTVVISEHRLHYLKKLIDRLIIMKDGQIIKDMSKHEIHSLNNFDLRNLGLRQFNLPKINVDKKVNGDNSFAACKGIVYIKNCYRILETVDLNLESGKVHVIVGENGAGKSSLCKIITGLYKQTEGGMYIDTAPVKKKERLQRTFFVGQDIDYQLYGYSIRNEFQIGNKRLTDEKIKACLDELHLKISLDTNPQVLSGGQKQRLLIGIAYLSGRDIIVFDEPTSGLDGFHMKIIADLFRYLAEKGKTIIVITHDIEFTAEVADTIIYMSKGKIQYHKYITNENR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-05-10" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PB5</accession>
    <name>TRMD_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmD</name>
        <name type="ordered locus">TDE_0884</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971494.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670221.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PB5"/>
    <dbReference type="SMR" id="Q73PB5"/>
    <dbReference type="STRING" id="243275.TDE_0884"/>
    <dbReference type="EnsemblBacteria" id="AAS11375">
        <property type="protein sequence ID" value="AAS11375"/>
        <property type="gene ID" value="TDE_0884"/>
    </dbReference>
    <dbReference type="GeneID" id="2739758"/>
    <dbReference type="KEGG" id="tde:TDE_0884"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.854"/>
    <dbReference type="eggNOG" id="COG0336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047363_0_1_12"/>
    <dbReference type="OMA" id="ILCGHYK"/>
    <dbReference type="OrthoDB" id="525632at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000060487" description="tRNA (guanine-N(1)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="130"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <sequence length="243" mass="27535" checksum="DFED87DCF7F345C7" modified="2004-07-05" version="1">MRFDVLTLFPEIPEAFFKTSIMAKAVEKGIISCNLVNIRDFAFDKHRSCDDIVYGGGAGMLLLPEPLSLALDSVNASSKRVIYVTPSGKPFNQELAKEFSSEEALVFVCGRYEGIDQRIIDEYVDDEISVGDYVMSSGELAALVIIDAVYRLIDGVISGESLEEESFSGFLLEYPQYTRPRNFKGKEVPEVLLSGHHLNIHKWRLKKRIEKTLKTRPDLIEKARNCGMWTKEAEKILKEFENE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-11-23" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PH3</accession>
    <name>Y826_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>UPF0339 protein TDE_0826</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_0826</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0339 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971436.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672132.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PH3"/>
    <dbReference type="SMR" id="Q73PH3"/>
    <dbReference type="STRING" id="243275.TDE_0826"/>
    <dbReference type="EnsemblBacteria" id="AAS11317">
        <property type="protein sequence ID" value="AAS11317"/>
        <property type="gene ID" value="TDE_0826"/>
    </dbReference>
    <dbReference type="GeneID" id="2739510"/>
    <dbReference type="KEGG" id="tde:TDE_0826"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.796"/>
    <dbReference type="eggNOG" id="COG3422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163886_1_2_12"/>
    <dbReference type="OMA" id="RREDCEH"/>
    <dbReference type="OrthoDB" id="1984963at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010879">
        <property type="entry name" value="DUF1508"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036913">
        <property type="entry name" value="YegP-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07411">
        <property type="entry name" value="DUF1508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160113">
        <property type="entry name" value="SSF160113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000218148" description="UPF0339 protein TDE_0826">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="58" mass="6250" checksum="10E6557F520A9A05" modified="2004-07-05" version="1">MAGKFEIYKDKSNKFRFRLKAGNGEVIAVGEAYESKAGCLSGIESVRKNAPDAAVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PQ9</accession>
    <name>Q73PQ9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971349.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681992.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0738"/>
    <dbReference type="EnsemblBacteria" id="AAS11230">
        <property type="protein sequence ID" value="AAS11230"/>
        <property type="gene ID" value="TDE_0738"/>
    </dbReference>
    <dbReference type="GeneID" id="2740292"/>
    <dbReference type="KEGG" id="tde:TDE_0738"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.714"/>
    <dbReference type="eggNOG" id="COG3077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154558_16_1_12"/>
    <dbReference type="OMA" id="ISFERIC"/>
    <dbReference type="OrthoDB" id="2086657at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="86" mass="9786" checksum="68C50E5F1BC6B23E" modified="2004-07-05" version="1">MTTISAKITQNDKISFERICDSMGINISSAINSFVKATIRENGLPFALKASEDPYIYSEENMKYLRKSIHQIETGKCQIHELKETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PR2</accession>
    <name>Q73PR2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971346.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681985.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0735"/>
    <dbReference type="EnsemblBacteria" id="AAS11227">
        <property type="protein sequence ID" value="AAS11227"/>
        <property type="gene ID" value="TDE_0735"/>
    </dbReference>
    <dbReference type="GeneID" id="2740099"/>
    <dbReference type="KEGG" id="tde:TDE_0735"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.712"/>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155761_1_1_12"/>
    <dbReference type="OMA" id="GEWRYRI"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="85" mass="9969" checksum="7462D47A20767030" modified="2004-07-05" version="1">MKVVLTETFKKQLKKLDATISKRVLDYLEQIELLDNPRSRGKALTSNLSGLWRYRVGDYRILCRICDDKLIITVIEIGHRSTVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PR4</accession>
    <name>Q73PR4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971344.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681975.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0732"/>
    <dbReference type="EnsemblBacteria" id="AAS11225">
        <property type="protein sequence ID" value="AAS11225"/>
        <property type="gene ID" value="TDE_0732"/>
    </dbReference>
    <dbReference type="GeneID" id="2740096"/>
    <dbReference type="KEGG" id="tde:TDE_0732"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.708"/>
    <dbReference type="eggNOG" id="ENOG5033R8E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622459_0_0_12"/>
    <dbReference type="OMA" id="YQTREET"/>
    <dbReference type="OrthoDB" id="1272067at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285885" evidence="1">
        <location>
            <begin position="21"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="440" mass="48883" checksum="E279ACD52A26547B" modified="2004-07-05" version="1">MKKNLLFLFLTASFFFFSCASLEDALDVKKPAYKETKEYTSMGEASSFLQAINKAKVGAIRQGVIDIIGSEAEKNNYERIEEELYNTEYPNKYVVNEKMDVLQKSKNGGVYIIKIKIPVKMNEVSAVLSKAGIFYQKNSSNKTMDDIVFGNGQSQGNPQVSQKPKDADLILKEAQASAEGKKNLQFLNNYIENMTYMVFDAEESDADRFLLKAAVETGNAFLLKQGYRAIDSKEVEKLKKDNALIYQESTDEGMSAIQLIAQKLNADVYMEIDAVTEGGYETSGYYGSAKITLKIFNPSTGELLGSVPYTSQKTFSRVSSYDAQSNAIQSAVNKALPMAVDQAKILLAKAYSRGIRYEIIINETPDSKSMARFRKALSGNVNDIKTLYQSSAQTKYAVSFFGTIDDLEAVIYDTADSVPGFENIKLVMLRGKTLTFKSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PR8</accession>
    <name>Q73PR8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971340.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681967.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0728"/>
    <dbReference type="EnsemblBacteria" id="AAS11221">
        <property type="protein sequence ID" value="AAS11221"/>
        <property type="gene ID" value="TDE_0728"/>
    </dbReference>
    <dbReference type="GeneID" id="2740092"/>
    <dbReference type="KEGG" id="tde:TDE_0728"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.704"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058050_4_1_12"/>
    <dbReference type="OMA" id="NIANGFY"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="281" mass="32233" checksum="2125C32F73E0021E" modified="2004-07-05" version="1">MTELTKNSIVYRARYMQEMQTILKNISNIKPIAGATGFLNHQTDEMIYLPEHILDLNFLPELKVISKTERYFEFGAAVTLNEILDLGKKNIPPSLYYSIEKIANNAIRSLATIGGNIATANPLSGTFLPMLALDAKLEIRTAENIEWVPFAKYIDKSYAEKREEKYIISRIRIPNETWTKSFYTRIGTPGYIGSDTASFLFLILIQKNILSDMRLFFASDKLIRNKEFDNLLLGRSLPLSQSEVPVIMQKAKQIFTPEQFSSEFHNSCFYNLLEDNLYNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PS9</accession>
    <name>Q73PS9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971329.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956803.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11210">
        <property type="protein sequence ID" value="AAS11210"/>
        <property type="gene ID" value="TDE_0717"/>
    </dbReference>
    <dbReference type="GeneID" id="2740624"/>
    <dbReference type="KEGG" id="tde:TDE_0717"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.694"/>
    <dbReference type="HOGENOM" id="CLU_1546879_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="173" mass="19557" checksum="C9F58ADD73B59CE2" modified="2004-07-05" version="1">MLFAFDFAPSWDFGHINIAGSFSKDSQILYGSGTLSDINLSDADTGVAFSFSPLEIESNQQLGKTNLFFINAEFSYNTFNNLYKIFRLAVFARINWLTESNIYKYRFMSGLEFSIMAEMSPFCDWKFPLIFKVFSAKTGFRLDYPAKPSFFCSAGITLSLPLYGLSQSANKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PT6</accession>
    <name>Q73PT6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971322.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11203">
        <property type="protein sequence ID" value="AAS11203"/>
        <property type="gene ID" value="TDE_0710"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0710"/>
    <dbReference type="HOGENOM" id="CLU_3105027_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="51" mass="6118" checksum="7CB5054E8004D2D2" modified="2004-07-05" version="1">MIEIKLSSLKNSSGIKCFYSSYLIPLEKNVLLFFIKNKRFDNKIYLFVRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PV2</accession>
    <name>Q73PV2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971306.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681918.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0694"/>
    <dbReference type="EnsemblBacteria" id="AAS11187">
        <property type="protein sequence ID" value="AAS11187"/>
        <property type="gene ID" value="TDE_0694"/>
    </dbReference>
    <dbReference type="GeneID" id="2739816"/>
    <dbReference type="KEGG" id="tde:TDE_0694"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.673"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="TTMRMIC"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="310" mass="35225" checksum="8AB215F6F7F3D7CD" modified="2004-07-05" version="1">MILTVKNLVKRYNEKTALDHFNMEVKEGEILGLLGPNGCGKTTAINCMLSLLKHGKGEIIIFGEEMKPNALHIKKRIGLVPQEVSVFYDFTVRQNIDYFCGLYVNNTQERKKLVDEAIDFVGLNNYASFRAKKLSGGLLRRLNIACGIAHKPELIFLDEPTVAVDAQSRNFILSGIKELAKRGSTIVYTTHYLEEVEELCDRIIIMDEGRDIANGTLEELHKLIRTSEKMVVEFVETKDNLQDELKKIPHVLEVTKNGNEFLISFENSINNLNELILFINNNSLAYTKLYSELPSLNDIFLELTGKELRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PW4</accession>
    <name>Q73PW4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secD</name>
        <name evidence="10" type="ordered locus">TDE_0681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971294.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681894.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0681"/>
    <dbReference type="EnsemblBacteria" id="AAS11175">
        <property type="protein sequence ID" value="AAS11175"/>
        <property type="gene ID" value="TDE_0681"/>
    </dbReference>
    <dbReference type="GeneID" id="2740240"/>
    <dbReference type="KEGG" id="tde:TDE_0681"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.662"/>
    <dbReference type="eggNOG" id="COG0342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007894_4_3_12"/>
    <dbReference type="OMA" id="MVVYYRL"/>
    <dbReference type="OrthoDB" id="121331at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="587" mass="64706" checksum="745B20DEA4B05E02" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q06</accession>
    <name>Q73Q06_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide/dipeptide ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971252.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681831.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0638"/>
    <dbReference type="EnsemblBacteria" id="AAS11133">
        <property type="protein sequence ID" value="AAS11133"/>
        <property type="gene ID" value="TDE_0638"/>
    </dbReference>
    <dbReference type="GeneID" id="2739363"/>
    <dbReference type="KEGG" id="tde:TDE_0638"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.616"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_0_12"/>
    <dbReference type="OMA" id="PSPPTWM"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="116"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="320" mass="35370" checksum="DAD793A4841A9DCE" modified="2004-07-05" version="1">MSEKKIASYDEPAKKLNLSPSDFEPVLRTKKTLQTTRVSIGFWEDVRRRFKKSKRALFSCAVLGLIILICSFGPILSGRSADDGNLKEKNLSPSFSHFFGTDELGRDIFTRVCKGGRVSLIIAIIGAAIDMGIGLIYGGLSAYTGGRTDTIMMRIVEILSSIPYLITAILISLIFGKGIFSIIIAMTITGWCFTARLVRGQVLQIKNQDFILAAQALGTGSFKIIIKHLLPNTVSIMIIALTFDIPSFIFGEAFLSYIGLGIQPPYTSWGVLASEAQKTMLFYPYQLFFPALFISLTILSLQIIGDALRDAMDPHLRKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q12</accession>
    <name>Q73Q12_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971246.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681819.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0632"/>
    <dbReference type="EnsemblBacteria" id="AAS11127">
        <property type="protein sequence ID" value="AAS11127"/>
        <property type="gene ID" value="TDE_0632"/>
    </dbReference>
    <dbReference type="GeneID" id="2739357"/>
    <dbReference type="KEGG" id="tde:TDE_0632"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_14_1_12"/>
    <dbReference type="OMA" id="YTITELQ"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="107" mass="11652" checksum="75A42E78BF61CDE5" modified="2004-07-05" version="1">MENLIINESEVSGCLLLSIEGSVNLYTSGDFEKKVYSAIKEHDTILDLSKVTSLSSSGIGVLMSAHNDSEDNGHKMYILNPAKDVKMALDSTGFSDVFNIIHSIDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q40</accession>
    <name>Q73Q40_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971218.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681784.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0604"/>
    <dbReference type="EnsemblBacteria" id="AAS11099">
        <property type="protein sequence ID" value="AAS11099"/>
        <property type="gene ID" value="TDE_0604"/>
    </dbReference>
    <dbReference type="GeneID" id="2739160"/>
    <dbReference type="KEGG" id="tde:TDE_0604"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.584"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064298_0_0_12"/>
    <dbReference type="OMA" id="RINMFLR"/>
    <dbReference type="OrthoDB" id="1238363at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014127">
        <property type="entry name" value="CHP02757"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09674">
        <property type="entry name" value="DUF2400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02757">
        <property type="entry name" value="TIGR02757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="266" mass="30719" checksum="465937BF4456A0D0" modified="2004-07-05" version="1">MSSQFKDLKKTLDKLVVKYEKPAFIPADPISIPHRFSKKEDIEIAGFFVSIFAWGNRTSILKSADKLMDILQNQPHAFLTQSTPAQLKIINTFYHRTLNGKDSLAIAKAIRRIYLSGSNFEELFKAKNQDEPLISRMSRFRKEFIKNMDPHNTKHIADMEGGSAAKRLNMFLRWMVRSKDKGVDFGLWKSVKPSELYLPLDVHCARRGRALGLLTRKQNDRKAVEEITERLREFCPEDPAKYDFALFAPEVEKALAERNYLHRNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q50</accession>
    <name>Q73Q50_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine protease domain, YopT-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971208.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0594"/>
    <dbReference type="EnsemblBacteria" id="AAS11089">
        <property type="protein sequence ID" value="AAS11089"/>
        <property type="gene ID" value="TDE_0594"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0594"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.574"/>
    <dbReference type="eggNOG" id="ENOG5032EYQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_983320_0_0_12"/>
    <dbReference type="OrthoDB" id="1114851at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285003" evidence="1">
        <location>
            <begin position="23"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="264" mass="30800" checksum="3CF770205EC2C6D9" modified="2004-07-05" version="1">MKKFLMITITVCLLAGGVNAFAYGINSFTVYDAQDNIVHKITAKSKVNALYLLFQESLQIAADEAFFMELPKDAQVLYRYVLSYNYGDDEQYFSFIVYKNYPLCRIPQLQEKEDIPKELTWKLFKYAYEIASRPAEVKKQLSYSAKNSYIRIYDDKGSLLLFTAGEKILDMFDTLFGKDIAEIEIEERNLKSLFTAESIHDGREVLVHYSFMDDDKIMKLYIYKDTKEMNITTDTGVLKVNLSEEAYRILSSPKSFQKEFEKRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q55</accession>
    <name>ACCA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="1">ACCase subunit alpha</shortName>
            <shortName evidence="1">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="1">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">accA</name>
        <name type="ordered locus">TDE_0589</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971203.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676956.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73Q55"/>
    <dbReference type="SMR" id="Q73Q55"/>
    <dbReference type="STRING" id="243275.TDE_0589"/>
    <dbReference type="EnsemblBacteria" id="AAS11084">
        <property type="protein sequence ID" value="AAS11084"/>
        <property type="gene ID" value="TDE_0589"/>
    </dbReference>
    <dbReference type="GeneID" id="2741552"/>
    <dbReference type="KEGG" id="tde:TDE_0589"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.569"/>
    <dbReference type="eggNOG" id="COG0825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_0_2_12"/>
    <dbReference type="OMA" id="TPWQRVQ"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000223846" description="Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01137"/>
        </source>
    </evidence>
    <sequence length="305" mass="33417" checksum="49EA71AE8D6EED9E" modified="2004-07-05" version="1">MSNKDQTNLLNNLKDIAQKAGLDISEELAKINAKLESSTALSKTWERVELARHSDRPRTLDYINLIFDNFTELHGDRFFGDDPAMIGGIGFIDGMPVTVIGTQKGRNLRETIDRNGGMANPEGYRKAMRLAKQAEKFKRPIITFIDTQGAYPGLGAEERGIGEAIAFNLREFSRLKTPIICIIIGEGGSGGALGIGVGDKIYMLENAIFSVISPEGCASILLRDSSRAKDAAAMLKITSQEVLDLKVINGIIPEPEKGAHTDPKKTADAIKEQILKDLADLTKRDPAVLVKYRSKKIRSIGKYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q80</accession>
    <name>Q73Q80_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971177.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681732.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0563"/>
    <dbReference type="EnsemblBacteria" id="AAS11058">
        <property type="protein sequence ID" value="AAS11058"/>
        <property type="gene ID" value="TDE_0563"/>
    </dbReference>
    <dbReference type="GeneID" id="2739808"/>
    <dbReference type="KEGG" id="tde:TDE_0563"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.547"/>
    <dbReference type="eggNOG" id="ENOG502ZMYT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110577_2_0_12"/>
    <dbReference type="OMA" id="NIWDYEE"/>
    <dbReference type="OrthoDB" id="1897239at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015068">
        <property type="entry name" value="DUF1877"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035944">
        <property type="entry name" value="YfbM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08974">
        <property type="entry name" value="DUF1877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111069">
        <property type="entry name" value="SSF111069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="165" mass="18826" checksum="DD2394D06C6B0CF5" modified="2004-07-05" version="1">MGMIANYQLISDRDLKKLMTEKDIADFTEELQEAENCILFDMDKMWDVLHFVLTGVSAGEPIEGNPLSEAIVGVDSFEGCEDFIGYTKKETIPLIVKKLNETDIDSLLENFSMQKCKKNKLYPNIWDYEDEKEEIIDELKCAFAGLKDFYNEAAQAGQNVLVSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QC1</accession>
    <name>Q73QC1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971136.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681656.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0522"/>
    <dbReference type="DNASU" id="2739259"/>
    <dbReference type="EnsemblBacteria" id="AAS11017">
        <property type="protein sequence ID" value="AAS11017"/>
        <property type="gene ID" value="TDE_0522"/>
    </dbReference>
    <dbReference type="GeneID" id="2739259"/>
    <dbReference type="KEGG" id="tde:TDE_0522"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.508"/>
    <dbReference type="eggNOG" id="ENOG502ZC6N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108537_0_0_12"/>
    <dbReference type="OMA" id="WACVNAR"/>
    <dbReference type="OrthoDB" id="1700639at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025368">
        <property type="entry name" value="DUF4272"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14094">
        <property type="entry name" value="DUF4272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="221" mass="25846" checksum="9672FD4FC099A3BA" modified="2004-07-05" version="1">MYIKPEDRREKSNAKIKGMGIACMEELPLRESSKEAKLKSSEEICDRAIACLLSIQLAEDIHNEQGYEESKELFLSLLEKYEVSGCLLEKEKRLFDGTYSEQDVIDVCWTYEAYWSLLWALGLVEDISYPNDICDVERAIRLVGDADGKTAFKAQCKLRGIEEILDMLDLHYRYHWATEEKRLRPETEIKDLNPDVLMERRRGLEWLISEESDWFDISMDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QD3</accession>
    <name>Q73QD3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971124.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681642.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0510"/>
    <dbReference type="EnsemblBacteria" id="AAS11005">
        <property type="protein sequence ID" value="AAS11005"/>
        <property type="gene ID" value="TDE_0510"/>
    </dbReference>
    <dbReference type="GeneID" id="2739607"/>
    <dbReference type="KEGG" id="tde:TDE_0510"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.496"/>
    <dbReference type="eggNOG" id="ENOG502ZA6Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114500_0_0_12"/>
    <dbReference type="OrthoDB" id="1277847at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="222" mass="25646" checksum="826A75E471F820A4" modified="2004-07-05" version="1">MDKLQYIRENEPLNILLMNECDIYFYKETGDTQFLENNEEYSLGCKSFAQDGSGGEYVFLEDGSIGFIGSEGEVGRAAESLDELLTFLIHTGCISDFSCKHIYKNKELLKTYCNGYISKIRERYKTQNKDWDKVRSDIANSLSLVFSPDKLENITMKFYKAATREPIFSCKYLDGKEEYICDSILSDIVGVWTMELVGMSREEIENYNQQPRCKRRGMSIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QF0</accession>
    <name>Q73QF0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971107.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681611.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0493"/>
    <dbReference type="EnsemblBacteria" id="AAS10988">
        <property type="protein sequence ID" value="AAS10988"/>
        <property type="gene ID" value="TDE_0493"/>
    </dbReference>
    <dbReference type="GeneID" id="2738978"/>
    <dbReference type="KEGG" id="tde:TDE_0493"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.478"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091968_1_0_12"/>
    <dbReference type="OMA" id="RPSWGYA"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="56"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="253" mass="29359" checksum="693CA39DB4C86D40" modified="2004-07-05" version="1">MEKQALLNQWLHEQETAHIKGWDFSHIRGRYKEEDDLPWDFGKIIKSYLSDTDYLLDMETGGGEFLLSFMTNAKHTAAIEGYEPNIKICEERLLPLGINFKACDGGDILPFENNYFDIITNRHGKYNVNEIKRTLKKGGVFLTQQVGAENDRDLVELLIGNIDIPFPEAYLNIARQEFADNGFDIIEEAEVYRPIEFYDVGALVWFARIIDWEFPGFEVEKYQKNLFKAQEILEKEGVIKGRIHRYYFAAAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QF7</accession>
    <name>Q73QF7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971100.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956754.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0486"/>
    <dbReference type="EnsemblBacteria" id="AAS10981">
        <property type="protein sequence ID" value="AAS10981"/>
        <property type="gene ID" value="TDE_0486"/>
    </dbReference>
    <dbReference type="GeneID" id="2741391"/>
    <dbReference type="KEGG" id="tde:TDE_0486"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.471"/>
    <dbReference type="eggNOG" id="COG4587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084465_0_1_12"/>
    <dbReference type="OMA" id="KTISWRM"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="266" mass="30188" checksum="7B6BD8F9922D630F" modified="2004-07-05" version="1">MKKYLSFFKIRFIANLQYRAAALAGISTQFAWGTLNIILFKAFYESSPENFPMGFSAFVSYIWMQQAFLAFFAMWTFESDITDSIVSGSIAYQMSKPINIYNLWFTRSVALRLARGLLRCFPVLIIASILPQPYRLIMPDLLTFFIFITSMILGLCTAAAFTCLIYVLCFFTVSPKGLQIVFFSASEMLMGQIIPIPFFPETIKKILEFSPFTGIQNIPLRIFSYDISSVDTGKKILLQVFWLLVLFLSGKIIARAAEKKLVVQGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QG0</accession>
    <name>Q73QG0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971097.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681579.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0483"/>
    <dbReference type="EnsemblBacteria" id="AAS10978">
        <property type="protein sequence ID" value="AAS10978"/>
        <property type="gene ID" value="TDE_0483"/>
    </dbReference>
    <dbReference type="GeneID" id="2741388"/>
    <dbReference type="KEGG" id="tde:TDE_0483"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.468"/>
    <dbReference type="eggNOG" id="COG4905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055257_2_2_12"/>
    <dbReference type="OMA" id="WWDYSDY"/>
    <dbReference type="OrthoDB" id="1898448at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010540">
        <property type="entry name" value="CmpB_TMEM229"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06541">
        <property type="entry name" value="ABC_trans_CmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="266" mass="30923" checksum="7FF82242C2B201C3" modified="2004-07-05" version="1">MALDYLILYFTIYSFIGWFCEVVYCSLLQRKFVLNRGMLYGPVCPIYGFGALILIFSLKNLIPYPIVLFFAAVLLTSSLEYAASFILEYLFDTLWWDYSKHKLNINGRVCALNSTLFGILGLALMYIVNPFISKYVNQIPDLFILIISKALLFIFIGDFIFTLKALIGLHDALLHIKNLTENFYTHLETLNIHERISESNIAESFNLLREKLKQDGYSAYEKVQEQLKLIAEKNKGHILSAFPNMRQRKNNLHLKLLKYFKEKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QG9</accession>
    <name>Q73QG9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971088.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681569.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0474"/>
    <dbReference type="EnsemblBacteria" id="AAS10969">
        <property type="protein sequence ID" value="AAS10969"/>
        <property type="gene ID" value="TDE_0474"/>
    </dbReference>
    <dbReference type="GeneID" id="2740521"/>
    <dbReference type="KEGG" id="tde:TDE_0474"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.459"/>
    <dbReference type="HOGENOM" id="CLU_177877_0_0_12"/>
    <dbReference type="OMA" id="CIEYDAK"/>
    <dbReference type="OrthoDB" id="1889931at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="104" mass="11934" checksum="63F7761F8028B42A" modified="2004-07-05" version="1">MTVSSFFPGHIRLRGEMIKDKDIFEAFEKAASSHKAVSKIERNERTGSLCIEYDAKALPLSKFEIFKEDLPELKKLSDAYISGKVEKEIIIEKISELWEKLKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QH6</accession>
    <name>Q73QH6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971081.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681562.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0467"/>
    <dbReference type="EnsemblBacteria" id="AAS10962">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284655" evidence="1">
        <location>
            <begin position="21"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="474" mass="53239" checksum="C1CB8387D16B1B57" modified="2004-07-05" version="1">MKKFFFTLVFILSISSLIFSEDDSLGDFGFDDEENGTESSVFSIDFGGAFYAGTEVFFDAFKKPENFKPPFPLWGSLHLEAKSPLAEAYASVNLNAKTIAAGMGETAEFFPGPLFPKWIDETYVQALTGPVVFGGGIKKINWGRANFFSVLDIVNPKDYGKPYEFYPEKIKKASPIFFLSAYLPKEMKLELVYLPVFEADEFALDGRWEKNTFANITRSLPSSADKEALFEAKKKLFSQQAPKANTFDYAQGGLRYSLTIDGKHDLGFQYFTGFLHEPNFKSDYKPSAHTEAEFTQVFDKAELTYNRYHQIGADYEAMFGQFTVQAEFAANITADLKGNNPDIYNPNLAWNLGLLYALPKNISLRLQAAETVRLLNSGINQDKLNLDTEKGNPITDTRLLFSISQTLVRGSLEWKLNAIVGIEDADFMINPELSWLIGTIDFDLGLGLFGGKKSGKLGRYQNNHFIKMSIGYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QR5</accession>
    <name>Q73QR5_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970992.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681398.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0378"/>
    <dbReference type="EnsemblBacteria" id="AAS10873">
        <property type="protein sequence ID" value="AAS10873"/>
        <property type="gene ID" value="TDE_0378"/>
    </dbReference>
    <dbReference type="GeneID" id="2739471"/>
    <dbReference type="KEGG" id="tde:TDE_0378"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.367"/>
    <dbReference type="HOGENOM" id="CLU_2439893_0_0_12"/>
    <dbReference type="OrthoDB" id="2009342at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="90" mass="10682" checksum="5AEA0D40B70A5059" modified="2004-07-05" version="1">MDFETYIDGAIKKMNSLGYKPTYFMQMRNDYGTIQAIKRLIHDPRPQGGFLKLHELGHPELTMESIVLEEQWHDLFTEEDRKAARNKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QS9</accession>
    <name>Q73QS9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0364</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970978.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681370.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0364"/>
    <dbReference type="EnsemblBacteria" id="AAS10859">
        <property type="protein sequence ID" value="AAS10859"/>
        <property type="gene ID" value="TDE_0364"/>
    </dbReference>
    <dbReference type="GeneID" id="2741084"/>
    <dbReference type="KEGG" id="tde:TDE_0364"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.354"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="11"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="310"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="348"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="518" mass="58646" checksum="44E262D3C788A9B0" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QU4</accession>
    <name>Q73QU4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoenolpyruvate synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="RefSeq" id="WP_002681327.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0349"/>
    <dbReference type="EnsemblBacteria" id="AAS10844">
        <property type="protein sequence ID" value="AAS10844"/>
        <property type="gene ID" value="TDE_0349"/>
    </dbReference>
    <dbReference type="GeneID" id="2741245"/>
    <dbReference type="KEGG" id="tde:TDE_0349"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.338"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005950_0_0_12"/>
    <dbReference type="OMA" id="WRSVKSH"/>
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    <dbReference type="Proteomes" id="UP000008212">
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    </dbReference>
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        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:phosphorylation"/>
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        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
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        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="SSF52009"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="16"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="1">
        <location>
            <begin position="749"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="825" mass="94300" checksum="569C8459223BE336" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R27</accession>
    <name>Q73R27_TREDE</name>
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        <recommendedName>
            <fullName evidence="1">SIR2_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS10761">
        <property type="protein sequence ID" value="AAS10761"/>
        <property type="gene ID" value="TDE_0266"/>
    </dbReference>
    <dbReference type="GeneID" id="2741250"/>
    <dbReference type="KEGG" id="tde:TDE_0266"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.259"/>
    <dbReference type="eggNOG" id="COG0846">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
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        <property type="entry name" value="SIR2-like"/>
    </dbReference>
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        <property type="entry name" value="Uncharacterised_Sir2-like"/>
    </dbReference>
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        <property type="entry name" value="SIR2_2"/>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033541">
        <property type="entry name" value="ORF25P_Sir2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIR2_2" evidence="1">
        <location>
            <begin position="102"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="263" mass="30254" checksum="DE98EDB1437452B1" modified="2004-07-05" version="1">MRDLISQYNEKKVILFVGAGVSKNLKLPTWSELIDQIAKDLDYDPDVFKTYGENLALAEYYRIIKGNIGPLRSWMDTNWHANGINISDSKIHELIAKAKFPIIYTTNYDRWLEKAFDAYSIAYTKIATVSDISKITDGVPQIVKFHGDFDYDATLVLDESSYYERLEFETPLDIKFRSDVLGKSVLFIGYSLSDVNVRYLYHKLKKLWKANVYGGVQPKSFFFTNRSNPIQAAILEQWGIKMIVSEEDNPQKALEVFLAKLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R30</accession>
    <name>Q73R30_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS10758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970877.1">
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    <dbReference type="RefSeq" id="WP_002681194.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0262"/>
    <dbReference type="EnsemblBacteria" id="AAS10758">
        <property type="protein sequence ID" value="AAS10758"/>
        <property type="gene ID" value="TDE_0262"/>
    </dbReference>
    <dbReference type="GeneID" id="2739687"/>
    <dbReference type="KEGG" id="tde:TDE_0262"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.257"/>
    <dbReference type="eggNOG" id="ENOG5031CPQ">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_806408_0_0_12"/>
    <dbReference type="OrthoDB" id="1919089at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="357" mass="42081" checksum="D1A7B113BD7856E7" modified="2004-07-05" version="1">MKKIILFSLLIFTSIPGFTYDYREILFGNNYENITECTDDEILKYFKNQKSIRDGDYGDKYVRLFEENYENGTVYRLLTSYETLNDENLSKIYENKMRLRQWVYIKVNGVFHEISYGYIYIQNSGDGTVTSWNEDNYGNVSVIERNNNIIGILEFNSAKRVISHSADSDDGESWETTERSTSANFKYWKDLQNESFYKNWLGDECLHLIRKDVEIPVINIDYSYPLIDKVRPFKYTIQNAFDGNPSTSYVEDTEDSTIKISLYSKNLNSNCIKMKIINGYAQNEMLYKNNNRIKVIDSFNEKSTAVTLKDKNLEPQIINWIDYSFYVKELYKGKKYNDTCIAELDFQSENGNWIFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R40</accession>
    <name>Q73R40_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970867.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681177.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0252"/>
    <dbReference type="EnsemblBacteria" id="AAS10748">
        <property type="protein sequence ID" value="AAS10748"/>
        <property type="gene ID" value="TDE_0252"/>
    </dbReference>
    <dbReference type="GeneID" id="2739677"/>
    <dbReference type="KEGG" id="tde:TDE_0252"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.247"/>
    <dbReference type="eggNOG" id="ENOG5032EYQ">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1022854_0_0_12"/>
    <dbReference type="OrthoDB" id="2113808at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284663" evidence="1">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="272" mass="31058" checksum="C8F25355F4BC456A" modified="2004-07-05" version="1">MIKMVKHIFFCAAFLLCAAFVFAADDNKVEDIPAIRVYDAKEVLVCELTEDVDIKAFNDLLLESVEVSVDDAAFVPAPTNAEIAYRYEIFKDSSNSISLLIYANSQIAYIPNTPKSDDMPDVFAWVLFGEAYNILSRPALLKKELIRYQNRYNNIFVYDAKGFLVSAASIPSALEMFGKIMDIYSGDIYENRFSGSVLPEKSVHKGRQLLYRYTVWSFNNETIRIYIYGNTDKAVLTKSFPDWAECTLSKEGYELFKNPKQLIKRLEKVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RB0</accession>
    <name>Q73RB0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0181</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970797.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681063.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0181"/>
    <dbReference type="EnsemblBacteria" id="AAS10678">
        <property type="protein sequence ID" value="AAS10678"/>
        <property type="gene ID" value="TDE_0181"/>
    </dbReference>
    <dbReference type="GeneID" id="2741606"/>
    <dbReference type="KEGG" id="tde:TDE_0181"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.177"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_12"/>
    <dbReference type="OMA" id="MNANISE"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="309"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="8">
        <location>
            <begin position="410"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="696" mass="74561" checksum="87FE5C00A86031F3" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RC7</accession>
    <name>Q73RC7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Low-potential electron donor to a number of redox enzymes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the flavodoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970779.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666607.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0163"/>
    <dbReference type="EnsemblBacteria" id="AAS10660">
        <property type="protein sequence ID" value="AAS10660"/>
        <property type="gene ID" value="TDE_0163"/>
    </dbReference>
    <dbReference type="GeneID" id="2739596"/>
    <dbReference type="KEGG" id="tde:TDE_0163"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.160"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_4_3_12"/>
    <dbReference type="OMA" id="FGSYDWG"/>
    <dbReference type="OrthoDB" id="1961680at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010087">
        <property type="entry name" value="Flav_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01753">
        <property type="entry name" value="flav_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="145" mass="15678" checksum="C3C6FA4D86175B4E" modified="2004-07-05" version="1">MAKIAVIYWSGTGNTQSMAESVLEGLKAGGAEASIFTVSEFGSKSIDDYDKIAFGCPAMGAEELEPDEFEPFFASIEGKLSGKKIALFGSYEWAGEGSGGEWMRNWEARSKDKGADLFEEGLIIYDAPTAAGKEKCKEFGERFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RE4</accession>
    <name>Q73RE4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thiamine ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_0145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970762.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681014.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0145"/>
    <dbReference type="TCDB" id="3.A.1.19.2">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10643">
        <property type="protein sequence ID" value="AAS10643"/>
        <property type="gene ID" value="TDE_0145"/>
    </dbReference>
    <dbReference type="GeneID" id="2739300"/>
    <dbReference type="KEGG" id="tde:TDE_0145"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.143"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="AMTREYM"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="8"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS10643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="210" mass="23145" checksum="DBE1ADF8C30F63EF" modified="2004-07-05" version="1">MENEKAFLQLKNIKKHFTEKDISISFELKKGKALALLGPSGCGKTTVLKIISGLVPPDSGEIILDGKNINHTPPGKRGIGMVFQDYALFPHLNVEENIIYGLVSQGMSKKEARKAITPLVELFHLEALQKRKTDLLSGGEKQRVSLARSLAVKPALILFDEPLSALDADLRLHLRKELRAKQESLGYTAVYVTHDKDEAAALADDVLYMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RM4</accession>
    <name>Q73RM4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="9">ATP-PFK</shortName>
            <shortName evidence="9">Phosphofructokinase</shortName>
            <ecNumber evidence="9">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pfk</name>
        <name evidence="9" type="synonym">pfkA</name>
        <name evidence="11" type="ordered locus">TDE_0064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="9"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970681.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666804.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0064"/>
    <dbReference type="EnsemblBacteria" id="AAS10562">
        <property type="protein sequence ID" value="AAS10562"/>
        <property type="gene ID" value="TDE_0064"/>
    </dbReference>
    <dbReference type="GeneID" id="2741679"/>
    <dbReference type="KEGG" id="tde:TDE_0064"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.65"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_7_4_12"/>
    <dbReference type="OMA" id="YGHERFA"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01981">
        <property type="entry name" value="Phosphofructokinase_II_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012004">
        <property type="entry name" value="PyroP-dep_PFK_TP0108"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000534">
        <property type="entry name" value="PPi_PFK_TP0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="10">
        <location>
            <begin position="80"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="252"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="360"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="178"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="9">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS10562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="438" mass="47810" checksum="A23D9D4FB40BB002" modified="2004-07-05" version="1">MKKTDFSISTLGECKIQSPIMLSETHGDLIANYVTDNEFIRYNLDASLGETGEPLTHADIIEKAGPRQKIYFSPNYVHAAIATCGGLCPGINDVIRAIVRCLWTRYGVRRISGIKFGYKGFISEYGFSPVPLTPEAVNGIHKTGGSFLGTSRGGGTRVTEIVDGIEQMNINMVFFIGGDGTQKGALEVSREIERRKLKISVIGIPKTIDNDLSFIQKSFGFDTAIAKATESVAAANMEASSQINGIGLVKLMGRESGFIATHTAIACHEAHFVLIPEVRFELGGENGFLKLLEKKLIENGYALIVAAEGAGQHLMNIEEETDASGNKKLADIGLFLKKEITEYFDKIGMHINLKYIDPSYQIRSSIAAPIDSVYCERLGNNAVHAAMAGKTRTLIGLVNNKFVHLPIEQVVSERKYVNPESSLWRDALDATGQPTTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RN2</accession>
    <name>Q73RN2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit omega</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_0056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970673.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666823.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0056"/>
    <dbReference type="EnsemblBacteria" id="AAS10554">
        <property type="protein sequence ID" value="AAS10554"/>
        <property type="gene ID" value="TDE_0056"/>
    </dbReference>
    <dbReference type="GeneID" id="2741671"/>
    <dbReference type="KEGG" id="tde:TDE_0056"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.58"/>
    <dbReference type="eggNOG" id="ENOG502ZVPX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187773_0_0_12"/>
    <dbReference type="OMA" id="SYQLSML"/>
    <dbReference type="OrthoDB" id="2018659at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="68" mass="7821" checksum="C0CDC5525A79B06F" modified="2004-07-05" version="1">MIFPLKELIEFDDNIYEITCASTRRAYQLAKIQDPNVEKSGDKVVSAGAKQIFTGEVNYQIERHPEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RP2</accession>
    <name>Q73RP2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970660.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680896.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0043"/>
    <dbReference type="EnsemblBacteria" id="AAS10541">
        <property type="protein sequence ID" value="AAS10541"/>
        <property type="gene ID" value="TDE_0043"/>
    </dbReference>
    <dbReference type="GeneID" id="2741658"/>
    <dbReference type="KEGG" id="tde:TDE_0043"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.45"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422062_0_0_12"/>
    <dbReference type="OMA" id="YSERASC"/>
    <dbReference type="OrthoDB" id="215967at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="412"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="581"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="627" mass="70946" checksum="B1842CD246AC9B1B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RP4</accession>
    <name>Q73RP4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bifunctional ligase/repressor BirA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Biotin--protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Biotin-[acetyl-CoA carboxylase] synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">birA</name>
        <name evidence="4" type="ordered locus">TDE_0041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:11756"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970658.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680895.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0041"/>
    <dbReference type="EnsemblBacteria" id="AAS10539">
        <property type="protein sequence ID" value="AAS10539"/>
        <property type="gene ID" value="TDE_0041"/>
    </dbReference>
    <dbReference type="GeneID" id="2741656"/>
    <dbReference type="KEGG" id="tde:TDE_0041"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.43"/>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_0_1_12"/>
    <dbReference type="OMA" id="AVWKHIE"/>
    <dbReference type="OrthoDB" id="1842956at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="94"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="2">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="2">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="352" mass="38248" checksum="48CE0B6AAB4F32F1" modified="2004-07-05" version="1">MGELISRTTSDILLDMLIEQNGSPLSGEEAALHLGLSRVSVWKAVQKLRDEGYEIEGGKNKGYILKSSSDVLNAFSIEKNLSAFAQSVCKGKVEVFKTIDSTNTEAKRRLTSSSRAESLHGTVLFAEHQSAGRGRFSRSFYSPKGAGLYFSLIFCPSIPARTEREVPSSDLYTAISATVICRCLKALGFAPQIKWVNDIYLNGKKICGILSEGIIDMETSSVQAVIIGIGLNVKESNFPPELKNKAGSLFTETGSSFSEAEVPSLNRNVLASSIMSSLIEALYGLHSQKNLMEEYKNLSLLTGKKVRVLPFAGIPYQALVLGISDLGHLIIETDDGKKEELISGEVSLELEP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q9X5A6</accession>
    <name>FLIP_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>Flagellar biosynthetic protein FliP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">fliP</name>
        <name type="ordered locus">TDE_2760</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1999-01" db="EMBL/GenBank/DDBJ databases">
            <title>Sequences of the tap1, flgD, flgE, orf4, motA, motB, fliL, fliM, fliY, and fliP Treponema denticola genes.</title>
            <authorList>
                <person name="Stamm L.V."/>
                <person name="Bergen H.L."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the flagellum-specific transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <dbReference type="EMBL" id="AF122909">
        <property type="protein sequence ID" value="AAD20625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973358.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680826.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9X5A6"/>
    <dbReference type="SMR" id="Q9X5A6"/>
    <dbReference type="STRING" id="243275.TDE_2760"/>
    <dbReference type="EnsemblBacteria" id="AAS13277">
        <property type="protein sequence ID" value="AAS13277"/>
        <property type="gene ID" value="TDE_2760"/>
    </dbReference>
    <dbReference type="GeneID" id="2740727"/>
    <dbReference type="KEGG" id="tde:TDE_2760"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2604"/>
    <dbReference type="eggNOG" id="COG1338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042028_1_0_12"/>
    <dbReference type="OMA" id="MPPNQIL"/>
    <dbReference type="OrthoDB" id="1049349at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005837">
        <property type="entry name" value="FliP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587:SF0">
        <property type="entry name" value="PTHR30587:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00951">
        <property type="entry name" value="FLGBIOSNFLIP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01103">
        <property type="entry name" value="fliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01060">
        <property type="entry name" value="FLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000191989" description="Flagellar biosynthetic protein FliP">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="271" mass="30920" checksum="09D70694B4BB66BD" modified="1999-11-01" version="1">MKKNLLILVFFGMILFIPVQVFSQSRFPEGTTAGRTDADPNRQAGRIPFIDFSIREPSTNKDVAFSVQLLIFITLISIAPSLLLLMTSFLRLSIVLDFVKRALSLQQVPPTQVLNGIAFFLTLFIMWPTFTQIYNNAYKPMSEGQIGIEEAYREAEKPMRYFMYKQMQKNPTHIRTFMAMSKLPKPDTLADVPTHILIAAFILHELTIAFQIGIFLYLPFIIIDMIVASILMSMGMIMLPPVQISMPFKLILFVMVDGWGLLFGKLFESFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>P62646</accession>
    <accession>Q73PZ6</accession>
    <name>CHEB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-glutamate methylesterase/protein-glutamine glutaminase</fullName>
            <ecNumber evidence="1">3.1.1.61</ecNumber>
            <ecNumber evidence="1">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cheB</name>
        <name type="ordered locus">TDE_0648</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="1"/>
    <dbReference type="EC" id="3.5.1.44" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971262.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677016.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P62646"/>
    <dbReference type="SMR" id="P62646"/>
    <dbReference type="STRING" id="243275.TDE_0648"/>
    <dbReference type="EnsemblBacteria" id="AAS11143">
        <property type="protein sequence ID" value="AAS11143"/>
        <property type="gene ID" value="TDE_0648"/>
    </dbReference>
    <dbReference type="GeneID" id="2740479"/>
    <dbReference type="KEGG" id="tde:TDE_0648"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.627"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_0_12"/>
    <dbReference type="OMA" id="MLEMHRA"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000158034" description="Protein-glutamate methylesterase/protein-glutamine glutaminase">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="5"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="1">
        <location>
            <begin position="178"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="372" mass="40348" checksum="0D6FAF7268D03CC8" modified="2004-07-19" version="1">MEDIRVLIVDDSALMRNLIGKIVDATPGLKIADKAMNGRFALQKLERVAPDVIVLDLEMPEMNGIEFLRELKKQNIKIPVVILSSIAKEGAKVTMDCLELGACDFITKPSGSESANLTTVSETLSKMLLAYGRRHQIETGTRSTDTTNSFSEPFKSTIPKPMTAAEPQKEEKPTPQREHGNIQIIAIGISTGGPNALRQVFASIDKDLPQPIVVVQHMPPGFTKEFALSLDKICPLEVKEAEDGDLIKPGRILIAPGGKHLVVEKRSLAAVAKVIDTEPQSGHKPSVDVLFGSVAKEYQNHALGIIMTGMGKDGAENITKLYTEGSRTIGQDEGSSVVYGMPRVAWEMGGVMEQVSLDNMAAAINRYGKEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J38</accession>
    <name>Q73J38_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligoendopeptidase F, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973336.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680798.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2738"/>
    <dbReference type="MEROPS" id="M03.010"/>
    <dbReference type="EnsemblBacteria" id="AAS13255">
        <property type="protein sequence ID" value="AAS13255"/>
        <property type="gene ID" value="TDE_2738"/>
    </dbReference>
    <dbReference type="GeneID" id="2740957"/>
    <dbReference type="KEGG" id="tde:TDE_2738"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2584"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030403_1_0_12"/>
    <dbReference type="OMA" id="CAFQFWK"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011976">
        <property type="entry name" value="Pept_M3B_oligopep-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02289">
        <property type="entry name" value="M3_not_pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="178"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS13255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="576" mass="66679" checksum="940FCD07B64E5A6F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J44</accession>
    <name>Q73J44_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973330.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2732"/>
    <dbReference type="EnsemblBacteria" id="AAS13249">
        <property type="protein sequence ID" value="AAS13249"/>
        <property type="gene ID" value="TDE_2732"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2732"/>
    <dbReference type="HOGENOM" id="CLU_3405985_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3449" checksum="8B849B16C632F76A" modified="2004-07-05" version="1">MKEYVIKTSPKLLCALSIFGVKLKKTFPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J71</accession>
    <name>Q73J71_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ISTde3, transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973303.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680749.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2705"/>
    <dbReference type="EnsemblBacteria" id="AAS13222">
        <property type="protein sequence ID" value="AAS13222"/>
        <property type="gene ID" value="TDE_2705"/>
    </dbReference>
    <dbReference type="GeneID" id="2739292"/>
    <dbReference type="KEGG" id="tde:TDE_2705"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2554"/>
    <dbReference type="eggNOG" id="COG3676">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044348_11_0_12"/>
    <dbReference type="OMA" id="SGRWINN"/>
    <dbReference type="OrthoDB" id="1667004at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024445">
        <property type="entry name" value="Tnp_ISXO2-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM01126">
        <property type="entry name" value="DDE_Tnp_IS1595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_IS1595" evidence="1">
        <location>
            <begin position="59"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="212" mass="24807" checksum="11A221B0B5920F07" modified="2004-07-05" version="1">MYTRLTTTKLNRIFLCFSEDITAAATAKITGINRNTVNRYFGIIREKILKYSIFEQTREISGNVRHISYFKKAKIRRKKIQEFIAARPVLGLLKKGKKIFVSLVHDDSHESLLSIIKGDLEKLISHQNKIEPFNTSLLKDCDQYRVFYNESEIKNEHTAGIENFLTFAKKRLAKFNGFSSGSFLLHLKECEFRYNHRDEDLCALIKKIFKKF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-29" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JG0</accession>
    <name>LSPA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="1">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Signal peptidase II</fullName>
            <shortName evidence="1">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lspA</name>
        <name type="ordered locus">TDE_2615</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973213.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680623.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JG0"/>
    <dbReference type="SMR" id="Q73JG0"/>
    <dbReference type="STRING" id="243275.TDE_2615"/>
    <dbReference type="EnsemblBacteria" id="AAS13132">
        <property type="protein sequence ID" value="AAS13132"/>
        <property type="gene ID" value="TDE_2615"/>
    </dbReference>
    <dbReference type="GeneID" id="2740789"/>
    <dbReference type="KEGG" id="tde:TDE_2615"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2472"/>
    <dbReference type="eggNOG" id="COG0597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083252_3_1_12"/>
    <dbReference type="OMA" id="NRWYFPA"/>
    <dbReference type="OrthoDB" id="1575081at2"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000289454" description="Lipoprotein signal peptidase">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <sequence length="173" mass="19150" checksum="D8E02EDEBE0FA95E" modified="2004-07-05" version="1">MNNKKDYYLPFLLTAIVIVVDQVTKILVVQYMSVNEVIPVIGDLVNLRFVYNTGAAFSLGAGFGEIARKILLVFLPFLLLIALTGAYLKSAELTRAQRWFICGILGGGFGNLIDRFFRSEGVVDFIDVKFFGILGMERWPTFNAADSFIVCCGIGLGVNLILQGIKQKKLKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JG4</accession>
    <name>Q73JG4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973209.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957276.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2611"/>
    <dbReference type="EnsemblBacteria" id="AAS13128">
        <property type="protein sequence ID" value="AAS13128"/>
        <property type="gene ID" value="TDE_2611"/>
    </dbReference>
    <dbReference type="GeneID" id="2740785"/>
    <dbReference type="KEGG" id="tde:TDE_2611"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2468"/>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025191_0_0_12"/>
    <dbReference type="OMA" id="RIHFSTR"/>
    <dbReference type="OrthoDB" id="1217774at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="739" mass="84052" checksum="55D0D6EB780C7739" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JL7</accession>
    <name>Q73JL7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Epimerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973000.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680329.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2401"/>
    <dbReference type="EnsemblBacteria" id="AAS12919">
        <property type="protein sequence ID" value="AAS12919"/>
        <property type="gene ID" value="TDE_2401"/>
    </dbReference>
    <dbReference type="GeneID" id="2740703"/>
    <dbReference type="KEGG" id="tde:TDE_2401"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2267"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_19_1_12"/>
    <dbReference type="OMA" id="HWHASPR"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="378" mass="41544" checksum="6B28A0ADF620F0E6" modified="2004-07-05" version="1">MTKRKILVTGSLGQIGSELVMFLRKEYGNDNVIASDIEKKDVPKVIGSGPFEKLDVLDGKKTLEVCKKYKVNTIIHLAALLSAVAEKNPQLAYQINLTGLHNMLELSREQKYSLFVPSSIAAFGPSTPADKTPQDTIQRPTSMYGVTKVAGELLCDYYHQKFGVDTRGVRFPGLISYEALPGGGTTDYAVHIYYEALKKGAYTSFIKKGTLMDMMYMPDALNAIFKLLEADPAKLKHRNAFNITAMSFAPETIAAEIKKHIPKFKMSYDVDPVRQAIADSWPNSLDDSCAKKEWGWKPKYNLESMTKDMLEKLSEKLGIELPNAKPAAVKVSTAKAPAAKKPAKSAKPTKTVKPAEKAPKAAAKKPAAKPSKGTEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JW9</accession>
    <name>Q73JW9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973116.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680483.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2518"/>
    <dbReference type="EnsemblBacteria" id="AAS13035">
        <property type="protein sequence ID" value="AAS13035"/>
        <property type="gene ID" value="TDE_2518"/>
    </dbReference>
    <dbReference type="GeneID" id="2739030"/>
    <dbReference type="KEGG" id="tde:TDE_2518"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2383"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_12"/>
    <dbReference type="OMA" id="NMAYFTP"/>
    <dbReference type="OrthoDB" id="1413173at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS13035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="276" mass="29634" checksum="95C7A3550549A49C" modified="2004-07-05" version="1">MSQTCNHECEGCNLTCNERTAAPNSFIESPNKLSSIKKVIAIISGKGGVGKSLITSLSAVQSQKKGYQCAILDADITGPSIPKAFGISGTVVGNDSGIFPAKTKTGIDIMSVNLLLENETDPVIWRGPVIAGTVKQFWTDVIWKDIDFMFIDMPPGTGDVPLTVFQSIPVDGIIVATSPQELVSMIVAKAVNMAKKMNIPIIGLVENFSYFTCPDNGKDYHIFGESGIDEIALEYGIPVLAKLPIDPEIAKACDKGKIENIDAPWFNPIVECIAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K20</accession>
    <name>Q73K20_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973169.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667298.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2571"/>
    <dbReference type="DNASU" id="2739936"/>
    <dbReference type="EnsemblBacteria" id="AAS13088">
        <property type="protein sequence ID" value="AAS13088"/>
        <property type="gene ID" value="TDE_2571"/>
    </dbReference>
    <dbReference type="GeneID" id="2739936"/>
    <dbReference type="KEGG" id="tde:TDE_2571"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2430"/>
    <dbReference type="eggNOG" id="COG4443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180137_1_0_12"/>
    <dbReference type="OMA" id="KFDIRDW"/>
    <dbReference type="OrthoDB" id="2012036at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017154">
        <property type="entry name" value="PC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037246">
        <property type="entry name" value="UCP037246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PC4" evidence="1">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="76" mass="8637" checksum="32094F31F64BD02D" modified="2004-07-05" version="1">MNNQDEFKFEITKSYGVISAGKGGWNTELNEVSWNGRDPKFDIRPWSPDHQKMGKGITLTRDELIALKKLLDEAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K48</accession>
    <name>Q73K48_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Precorrin-8W decarboxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2374</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972973.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680297.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2374"/>
    <dbReference type="EnsemblBacteria" id="AAS12892">
        <property type="protein sequence ID" value="AAS12892"/>
        <property type="gene ID" value="TDE_2374"/>
    </dbReference>
    <dbReference type="GeneID" id="2739983"/>
    <dbReference type="KEGG" id="tde:TDE_2374"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2242"/>
    <dbReference type="eggNOG" id="COG2242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094143_0_0_12"/>
    <dbReference type="OMA" id="RCKFVYA"/>
    <dbReference type="OrthoDB" id="1706318at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="187" mass="20542" checksum="B2A5EDC345EBB41F" modified="2004-07-05" version="1">MKNIKDSEFIRGEVPMTKFNIRSLSIAHLQIEKGDKLLDIGGGTGSVSVEAALQGADVLTVEFDKTAYALIKENAKKFGVKINLILGKAPEALLAAEYKDLQFDKCFIGGSGGELKNIFDYLESHLKKGGIICANFILIKNLNEFLELLEKYGYTEIEADLIQTASMGRTGLFKGENPIYIVRACKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K71</accession>
    <name>Q73K71_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972950.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680267.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2351"/>
    <dbReference type="EnsemblBacteria" id="AAS12869">
        <property type="protein sequence ID" value="AAS12869"/>
        <property type="gene ID" value="TDE_2351"/>
    </dbReference>
    <dbReference type="GeneID" id="2739960"/>
    <dbReference type="KEGG" id="tde:TDE_2351"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2219"/>
    <dbReference type="eggNOG" id="ENOG5031C4H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131004_0_0_12"/>
    <dbReference type="OMA" id="YECIALL"/>
    <dbReference type="OrthoDB" id="1860311at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="163" mass="18927" checksum="A87FFDEF6391254A" modified="2004-07-05" version="1">MEKHSVAADIKSILHEQIDLIDNIYNLQKAMYQGVLDRDWQESERNLSSLNEASVKFSDLDKRLYGLLQPDEDDYQEFDFYMHTKQFTSSEKKKIDSLYEKLKEKVFYSKIENDVFSNYVSHAQALVKGVVDIISEERNGKCYTAAGKRVNTEITSLVLNEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KB3</accession>
    <name>Q73KB3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12825">
        <property type="protein sequence ID" value="AAS12825"/>
        <property type="gene ID" value="TDE_2306"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2306"/>
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    <dbReference type="HOGENOM" id="CLU_3349897_0_0_12"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="37" mass="4435" checksum="C3FB23BA1B081150" modified="2004-07-05" version="1">MIESVKPADKLFDSFRYQVCVEKKRPEHCPAFFMLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KC5</accession>
    <name>Q73KC5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972893.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680206.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2293"/>
    <dbReference type="EnsemblBacteria" id="AAS12812">
        <property type="protein sequence ID" value="AAS12812"/>
        <property type="gene ID" value="TDE_2293"/>
    </dbReference>
    <dbReference type="GeneID" id="2740258"/>
    <dbReference type="KEGG" id="tde:TDE_2293"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2163"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004535_0_0_12"/>
    <dbReference type="OMA" id="QSLMNSM"/>
    <dbReference type="OrthoDB" id="791690at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="574"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="716"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="880"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1081" mass="123107" checksum="6490D3EA8068C18A" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KD1</accession>
    <name>Q73KD1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972887.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674352.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2287"/>
    <dbReference type="EnsemblBacteria" id="AAS12806">
        <property type="protein sequence ID" value="AAS12806"/>
        <property type="gene ID" value="TDE_2287"/>
    </dbReference>
    <dbReference type="GeneID" id="2740252"/>
    <dbReference type="KEGG" id="tde:TDE_2287"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2157"/>
    <dbReference type="eggNOG" id="COG0545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_0_1_12"/>
    <dbReference type="OMA" id="KYMSGHI"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000774">
        <property type="entry name" value="PPIase_FKBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036944">
        <property type="entry name" value="PPIase_FKBP_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01346">
        <property type="entry name" value="FKBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285927" description="Peptidyl-prolyl cis-trans isomerase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="156"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="249" mass="27563" checksum="6DFA24FDA95350AE" modified="2004-07-05" version="1">MKFIKNFTLILCCACLFFAFTSCKDKKAETEVPSENNAADEKEKISVTEEEVGYAFGVIIAQSAKQDGIKLNPKHILKGYNEAMAKDFKETGLQDAQTVLNKAFKMAQIEKAAKALEEANAFLEKNKAKEGVVVTESGLQYEVLSKGKEDFYPTANDEVEVNYIGKLIDESVFDDSYKSGSSVKIQLSRVIPGWKEGLQLMSQDAKFRLYVPPALAYGEQGITQGNTVIIPPNAVLIFDIELVNILPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KE2</accession>
    <name>Q73KE2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972876.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2276"/>
    <dbReference type="EnsemblBacteria" id="AAS12795">
        <property type="protein sequence ID" value="AAS12795"/>
        <property type="gene ID" value="TDE_2276"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2276"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2147"/>
    <dbReference type="eggNOG" id="ENOG5031CSF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1204341_0_0_12"/>
    <dbReference type="OrthoDB" id="1656675at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="243" mass="28224" checksum="C9F584254764592D" modified="2004-07-05" version="1">MSVNLLNLILFQCMLTNMQIAALMFLSFALAIIWAFIVIRKENLSVKPLLYIFLFSFFAVLISILMQTIVYFLSQDFLKTTGYAYGILFDCFIHSSLPEETVKALLFSIFVKLLWSDKMKNMDEITPAQNRANIRILMLLSVFYGLIFASFENLAYAIRYPEAIWLRSFTSNILHACLGVYYLEISMVQKTRNIIKPFLFTWGIHGLYNMFFSIGSYFVIFGIVIVFFVISNAVSRYDRFKSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KK2</accession>
    <accession>Q9ZGA2</accession>
    <name>MGLA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Galactose/methyl galactoside import ATP-binding protein MglA</fullName>
            <ecNumber evidence="1">7.5.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mglA</name>
        <name type="ordered locus">TDE_2216</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="DNA Seq." volume="11" first="419" last="431">
            <title>MglA and mglB of Treponema denticola; similarity to ABC transport and spa genes.</title>
            <authorList>
                <person name="Lepine G."/>
                <person name="Ellen R.P."/>
            </authorList>
            <dbReference type="PubMed" id="11328650"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-galactose(out) + H2O = ADP + D-galactose(in) + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:60156"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.5.2.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.</text>
    </comment>
    <dbReference type="EC" id="7.5.2.11" evidence="1"/>
    <dbReference type="EMBL" id="AF082511">
        <property type="protein sequence ID" value="AAD05298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972816.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680067.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KK2"/>
    <dbReference type="SMR" id="Q73KK2"/>
    <dbReference type="STRING" id="243275.TDE_2216"/>
    <dbReference type="EnsemblBacteria" id="AAS12735">
        <property type="protein sequence ID" value="AAS12735"/>
        <property type="gene ID" value="TDE_2216"/>
    </dbReference>
    <dbReference type="GeneID" id="2739492"/>
    <dbReference type="KEGG" id="tde:TDE_2216"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2093"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_12"/>
    <dbReference type="OMA" id="AKREIYQ"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="BRENDA" id="7.5.2.11">
        <property type="organism ID" value="6426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043211">
        <property type="term" value="F:ABC-type carbohydrate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015862">
        <property type="entry name" value="ABC_transpr_MglA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790:SF7">
        <property type="entry name" value="PTHR43790:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51260">
        <property type="entry name" value="MGLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000261376" description="Galactose/methyl galactoside import ATP-binding protein MglA">
        <location>
            <begin position="1"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="1">
        <location>
            <begin position="252"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAD05298." evidence="2" ref="1">
        <original>E</original>
        <variation>G</variation>
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="497" mass="55284" checksum="D70DFF1DA2EF0500" modified="2004-07-05" version="1">MSDVVLEIKNLSKSFGKNKVLDGINLTVRQGSVMGLMGENGAGKSTMMKCLFGIYTRDEGAISLLNKSIEFKNPKEALESGVAMVHQELNLCLDRTVTDNLFLGRYPTNFGIVDEIKMFESASSLFSSLNMNVNPKTIMRTMSVSQRQMVEIAKAVSYNAKLIVLDEPTSSLTEREVKKLFSIIRALQKKGVSFIYISHKMDEVFEVCDEVAVLRDGKMILSKPVAGTNMNEIISAMVGRSLDKRFPDVDNVPGEDFLKIENLKTKYAPVLEDISFTVRKGEILGLYGLVGAGRSELLEALFGIRTIESGSISINDKYLKFKSSKEAMAHGFALLTEERKLNGMFGKDTIEFNTVITNLNNYKTIGVLSKRKIREAANREIETMRTRCLSADQGISALSGGNQQKVIIGKWLERSPDVFLMDEPTRGIDVGAKYEIYQLIIKMAKEGKTIIVVSSEMPEILGITNRIAVMSNRRLAGIVNTKETDQETLLRLSAKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KL5</accession>
    <name>Q73KL5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972803.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680043.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2202"/>
    <dbReference type="EnsemblBacteria" id="AAS12722">
        <property type="protein sequence ID" value="AAS12722"/>
        <property type="gene ID" value="TDE_2202"/>
    </dbReference>
    <dbReference type="GeneID" id="2739478"/>
    <dbReference type="KEGG" id="tde:TDE_2202"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2078"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_4_1_12"/>
    <dbReference type="OMA" id="LWMTGLK"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="149"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="296" mass="32079" checksum="6AEC1FECEDCE7C24" modified="2004-07-05" version="1">MSNKIKSYLSAITAIVFFGSSFPFSRFALTHFGPEALGFLRCFLASLVLLIMGRFNKIRAPFKLKHIGLFFLSGALGFALYLIFFNMGIRTITAATSSIIIATTPIMTAAAASVIYSEKISNAGWFSILTAFCGVLVIILWKGILSVNIGILWTMSAAISFCGYNILSRKLAKMGYTSIEIVTYSMICAAAILSPFCIDGYKELSSAGFKYIGSLLYLGIFTSALGYFFFNKGIEIAEKTSDITNFLFFNPLIASILSYLALGETFNTGTAIGGTIIIASIIVFALKGEQKKAADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KM0</accession>
    <name>Q73KM0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2197"/>
    <dbReference type="EnsemblBacteria" id="AAS12717">
        <property type="protein sequence ID" value="AAS12717"/>
        <property type="gene ID" value="TDE_2197"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2197"/>
    <dbReference type="HOGENOM" id="CLU_3384326_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="33" mass="3764" checksum="E4016A4D65D7C8EE" modified="2004-07-05" version="1">MTGGHPFLTGTGCPLFLIFRLFFVKAYFSFTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KN0</accession>
    <name>Q73KN0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParB-like nuclease domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972788.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668053.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2187"/>
    <dbReference type="EnsemblBacteria" id="AAS12707">
        <property type="protein sequence ID" value="AAS12707"/>
        <property type="gene ID" value="TDE_2187"/>
    </dbReference>
    <dbReference type="GeneID" id="2740209"/>
    <dbReference type="KEGG" id="tde:TDE_2187"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2064"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150097_0_0_12"/>
    <dbReference type="OMA" id="FRRIWNA"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="133" mass="15590" checksum="3C7D3EEE38AACE10" modified="2004-07-05" version="1">MQIPIEKIKVRQRARKEFIEIEELAESLNRVGLLNPIIVDQNKVLIAGQRRLEAAKKLGWKTIEARVLSVEDESLALDIEIEENVQRQQFSNEELLNAFTRLNRLKNPGFFVRIWRSIKAFFKRLFGKKKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KQ1</accession>
    <name>Q73KQ1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">hypA</name>
        <name evidence="5" type="ordered locus">TDE_2166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972767.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675609.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2166"/>
    <dbReference type="EnsemblBacteria" id="AAS12686">
        <property type="protein sequence ID" value="AAS12686"/>
        <property type="gene ID" value="TDE_2166"/>
    </dbReference>
    <dbReference type="GeneID" id="2739152"/>
    <dbReference type="KEGG" id="tde:TDE_2166"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2047"/>
    <dbReference type="eggNOG" id="COG0375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126929_3_0_12"/>
    <dbReference type="OrthoDB" id="1995603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="113" mass="12614" checksum="E84EA3E7A35BFF7D" modified="2004-07-05" version="1">MHELSLVMEVVRRVDAIAKSNNVSEVDTIVLQIGEIATVVPHFVQACYPAAIDGTWMADTKLKIEMVKASVRCNNCNKVFDPIEYHGVCPACSCDEHEILTGREFVIKEIVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KU5</accession>
    <name>Q73KU5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DHH superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972723.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002683696.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2122"/>
    <dbReference type="EnsemblBacteria" id="AAS12642">
        <property type="protein sequence ID" value="AAS12642"/>
        <property type="gene ID" value="TDE_2122"/>
    </dbReference>
    <dbReference type="GeneID" id="2739381"/>
    <dbReference type="KEGG" id="tde:TDE_2122"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2005"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700087_0_0_12"/>
    <dbReference type="OMA" id="EMASHIH"/>
    <dbReference type="OrthoDB" id="869989at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="37"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="394" mass="44385" checksum="07F42BF7B6A4DC1D" modified="2004-07-05" version="1">MSSSNSETKKIKPISIGRKNAVMERIFELIYEKSSFLLLGHKHADEDCFSSVVAFGLLLRKFGKTVNIFLEDNVPDNLSFFADICRYNFISLFVNDVTEVINPDVVVILDTPKPDMIASNDAIEVFLKDKTLPKVEIDHHFAADADYSGDEDYRLTLRASSTCEIIGQMCLKLEKRPEILKKYGIHELYSRNIVLAMLTGMIGDAKMGNYLFKRRDKAFYDYFSKKFNSILHEKFNEGSQNISSVNEIVDVMEKLSDEDARIYESVMKNASYDGRVGVIILDEKQSDSLSSGIDYNQFLGVIKRATDNIAEKVHGVGISAYFDPVEISDKIQLRIRASGDVKGIDVRPILSEFGIEDGGGHPGAIGFRFPRTEIKDLPAYVEKISKKIKTLIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KV0</accession>
    <name>Q73KV0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0164 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972718.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679928.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2117"/>
    <dbReference type="EnsemblBacteria" id="AAS12637">
        <property type="protein sequence ID" value="AAS12637"/>
        <property type="gene ID" value="TDE_2117"/>
    </dbReference>
    <dbReference type="GeneID" id="2739376"/>
    <dbReference type="KEGG" id="tde:TDE_2117"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2000"/>
    <dbReference type="eggNOG" id="ENOG5033RFB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665499_0_0_12"/>
    <dbReference type="OMA" id="KWLIPNG"/>
    <dbReference type="OrthoDB" id="848913at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005362">
        <property type="entry name" value="UPF0164"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03687">
        <property type="entry name" value="UPF0164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="429" mass="47660" checksum="06E1C82EB1E4EC06" modified="2004-07-05" version="1">MKRIFQAVCISIFLIFPKIGLFCADISNFYSGVSSIFDIFTQKFEGETAFRSLLIPSGGRFEGLGGTFTALSNDISFFDANPAASALLKETELNVLHNSWIADSKLETLGYTQRKNHLGWGTSLRCFYIPFTEYGPLGQKKASGYYSETFLTANIAYNFFAGYDFKGLTVGGSIKTGIRSMPPFSGQGEAADPDNPTPQYKNASQQNGYAVLGDFGIMIRANVTKIFYSDEPNFYFGLSLKNFGPPIKGDIPPSYISLGFAYRPVNFFLFGIDVNQGINIVNIKNSGLPYGSLGFMFSITKYFNLLTGLGIKGGNPRFTLGGEVNLSDVQISANYTLDLSSQVTNISRISVGVKLLLGQDKRDEKLSTVKKLYVQALKEYNNKNYEKAIELWKEILTIDKRYDPAIEGIARAEQQLRLLEEIKKILFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L52</accession>
    <name>Q73L52_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972616.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679775.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12527">
        <property type="protein sequence ID" value="AAS12527"/>
        <property type="gene ID" value="TDE_2013"/>
    </dbReference>
    <dbReference type="GeneID" id="2740360"/>
    <dbReference type="KEGG" id="tde:TDE_2013"/>
    <dbReference type="HOGENOM" id="CLU_2398691_0_0_12"/>
    <dbReference type="OrthoDB" id="2133903at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="115" mass="13402" checksum="BC488EB223FC4985" modified="2004-07-05" version="1">MFIRVNPFLGISIFIYFISGAIMRLYLQIKGGRLISKRLNCLESLGIDKILLFIPEFVPLSVLKPIYEGLSIFDTEKYELEDYIKMLKIYRRIYVVPCFIGGSITLLYTFIRAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L66</accession>
    <name>Q73L66_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972602.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669823.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1999"/>
    <dbReference type="EnsemblBacteria" id="AAS12513">
        <property type="protein sequence ID" value="AAS12513"/>
        <property type="gene ID" value="TDE_1999"/>
    </dbReference>
    <dbReference type="GeneID" id="2740452"/>
    <dbReference type="KEGG" id="tde:TDE_1999"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1887"/>
    <dbReference type="eggNOG" id="COG0847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047806_7_1_12"/>
    <dbReference type="OMA" id="FHVYLNP"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006054">
        <property type="entry name" value="DnaQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00573">
        <property type="entry name" value="dnaq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="15"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="217" mass="24522" checksum="EC7DDE86D5AF1153" modified="2004-07-05" version="1">MSSYDWISAVYDKAVFTAFDTETTGTEAKAERVVEIGCVKFDIRGVIARYNVLIDPEKPMPPEAGKVNQITDEMLAGQPKFAEVLPDFLDFIRNTVLVAHNASFDINFINCELERCGKTKLTNKVFDTLTFARETLPGLQSYALQNLATQFGVQAVNAHRAEDDARVCMEFFKIAVSHFFEKNKDMLDYYKKDVDISEYLSTKDPETDGGKLVQNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L89</accession>
    <name>Q73L89_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972579.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679709.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1976"/>
    <dbReference type="EnsemblBacteria" id="AAS12490">
        <property type="protein sequence ID" value="AAS12490"/>
        <property type="gene ID" value="TDE_1976"/>
    </dbReference>
    <dbReference type="GeneID" id="2741539"/>
    <dbReference type="KEGG" id="tde:TDE_1976"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1867"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057504_0_2_12"/>
    <dbReference type="OMA" id="NTRELYY"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="287" mass="33678" checksum="D6E0954E508CA039" modified="2004-07-05" version="1">MKKLFKVTLRNDYAFKKVFGTEENKDVLQDLLECILDIPPENIAGLELLDKEFHKDSISDKTGVLDVKLRLKNNTIIDVEIQNRWNSEFVQRTIFYWAKMYTENLKTGEVYTKLPKCITINIVGEGFNLNSLLHSEYNVVEKHINDRLSDEFEIHFLNLAKVKDDENIGQDEKKKKLYNWLRFIETDDEEVRNMLAQESPIMAKANATINIMEMSPKEKWLYENRMKYEHDKASWKHVGYQEGIERGFADGAYQKSIETARIMKHEAFDLNIISKITGLSKEEIDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LA3</accession>
    <name>Q73LA3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972565.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669791.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1962"/>
    <dbReference type="EnsemblBacteria" id="AAS12476">
        <property type="protein sequence ID" value="AAS12476"/>
        <property type="gene ID" value="TDE_1962"/>
    </dbReference>
    <dbReference type="GeneID" id="2741525"/>
    <dbReference type="KEGG" id="tde:TDE_1962"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1854"/>
    <dbReference type="eggNOG" id="COG3905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173961_0_0_12"/>
    <dbReference type="OMA" id="DLAQNRK"/>
    <dbReference type="OrthoDB" id="2016452at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="83" mass="9793" checksum="92518AE11D4AEF69" modified="2004-07-05" version="1">MTTVRLPVEYEQRLNFLSTVKKKNKSDLIKEALDMLFHNEEMEIDSYELGKEYFGKYGSGNSNLSVSYKQKIKEKINAKYRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LC4</accession>
    <name>Q73LC4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972544.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679659.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1941"/>
    <dbReference type="EnsemblBacteria" id="AAS12455">
        <property type="protein sequence ID" value="AAS12455"/>
        <property type="gene ID" value="TDE_1941"/>
    </dbReference>
    <dbReference type="GeneID" id="2740181"/>
    <dbReference type="KEGG" id="tde:TDE_1941"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1834"/>
    <dbReference type="eggNOG" id="ENOG5030IF4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_315440_0_0_12"/>
    <dbReference type="OMA" id="HEDEHIK"/>
    <dbReference type="OrthoDB" id="126966at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="926" mass="103219" checksum="B2BA3CAFD50C1B4D" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LE9</accession>
    <name>GLPK_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol kinase</fullName>
            <ecNumber evidence="1">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycerokinase</fullName>
            <shortName evidence="1">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glpK</name>
        <name type="ordered locus">TDE_1916</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972519.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669730.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73LE9"/>
    <dbReference type="SMR" id="Q73LE9"/>
    <dbReference type="STRING" id="243275.TDE_1916"/>
    <dbReference type="EnsemblBacteria" id="AAS12430">
        <property type="protein sequence ID" value="AAS12430"/>
        <property type="gene ID" value="TDE_1916"/>
    </dbReference>
    <dbReference type="GeneID" id="2740414"/>
    <dbReference type="KEGG" id="tde:TDE_1916"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1813"/>
    <dbReference type="eggNOG" id="COG0554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_12"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="233605at2"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0319">Glycerol metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000020807" description="Glycerol kinase">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="410"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <sequence length="496" mass="55492" checksum="DD88EAF4C8702D76" modified="2004-07-05" version="1">MKKYVLAFDQGTTSCRAILFDKDGKKIETAQQEFSQIFPKQGWVEHDAMEIWGKQSGVAREVLERSGVSTQEIAAIGITNQRETTVVWNKNTGRPVCNAIVWQCRRTADICDALKEKGLSDSIRKKTGLIIDAYFSGTKIKWILDNVPEARTLAEKGELLFGNIDTWLIWNLTRGKVHVTDYTNASRTLLFNIHTLQWDKELLKAMDIPESMLPEVKPSSYVYGYTEEHTFGGSKIPIAGAAGDQQAALFGQACFEEGSAKNTYGTGCFMLMNTGDKIIESENGLLTTIAFGIDNSVKYALEGSSFIAGAAVQWLRDELKLIYTAHETEYYAGLVNDTNGVYFVPAFSGLGAPYWDMYARGALLGLTRGAKREHIVRAVLEAIAYQTKDVLYAMEKDSKINLKSLKVDGGACANNFLMQFQSDILNVPVLRPYEKETTALGAAYLAGLAVGFWKEQGEIKRIQDIEREFRPDMEEEKRKTLYAGWKKAVERSMKWA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LF4</accession>
    <name>DXS_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="1">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="1">DXP synthase</shortName>
            <shortName evidence="1">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dxs</name>
        <name type="ordered locus">TDE_1910</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="1">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972513.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957098.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73LF4"/>
    <dbReference type="SMR" id="Q73LF4"/>
    <dbReference type="STRING" id="243275.TDE_1910"/>
    <dbReference type="PRIDE" id="Q73LF4"/>
    <dbReference type="EnsemblBacteria" id="AAS12424">
        <property type="protein sequence ID" value="AAS12424"/>
        <property type="gene ID" value="TDE_1910"/>
    </dbReference>
    <dbReference type="GeneID" id="2740408"/>
    <dbReference type="KEGG" id="tde:TDE_1910"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1808"/>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_4_12"/>
    <dbReference type="OMA" id="QVGYHAQ"/>
    <dbReference type="OrthoDB" id="566385at2"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DXP_synthase_N"/>
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        <property type="entry name" value="Transket_pyr"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
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        <property type="entry name" value="SSF52518"/>
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        <property type="entry name" value="SSF52922"/>
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        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000256501" description="1-deoxy-D-xylulose-5-phosphate synthase">
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            <begin position="1"/>
            <end position="653"/>
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        <location>
            <position position="76"/>
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        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <sequence length="653" mass="71550" checksum="37D8480E37B0F973" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LH0</accession>
    <name>Q73LH0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ion-translocating oxidoreductase complex subunit B</fullName>
            <ecNumber evidence="5">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Rnf electron transport complex subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnfB</name>
        <name evidence="8" type="ordered locus">TDE_1894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 3 [4Fe-4S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972497.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="RefSeq" id="WP_002669703.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="STRING" id="243275.TDE_1894"/>
    <dbReference type="EnsemblBacteria" id="AAS12408">
        <property type="protein sequence ID" value="AAS12408"/>
        <property type="gene ID" value="TDE_1894"/>
    </dbReference>
    <dbReference type="GeneID" id="2739123"/>
    <dbReference type="KEGG" id="tde:TDE_1894"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1793"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="eggNOG" id="COG2878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053470_0_0_12"/>
    <dbReference type="OMA" id="MLPGANC"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RsxB_RnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4Fe-4S_dom"/>
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        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
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        <property type="entry name" value="Elect_transpt_cplx_RnfB/RsxB"/>
    </dbReference>
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        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S" evidence="7">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
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            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
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            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
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            <end position="236"/>
        </location>
    </feature>
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        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Hydrophobic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
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            <name>[4Fe-4S] cluster</name>
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            <label>1</label>
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        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
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            <label>1</label>
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    </feature>
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            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
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            <name>[4Fe-4S] cluster</name>
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            <label>2</label>
        </ligand>
    </feature>
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        <location>
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        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="150"/>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
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        <location>
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            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="282" mass="29497" checksum="FCFFEB1D86E62135" modified="2004-07-05" version="1">MNIILLTLAVSLVLSLLLGLLLGFFKKIFYVEPDKTAAAVREVLPGANCGACGYPGCDGFAAAVAAGDAPVNGCPVGAAPVAEAIGKIMGVNASASARVAVLTCQGSHDVCRDKCDYVGVKTCKAAKISINGTKECDWGCIGLGDCERACPFDAIHIKENGLPEVDYDKCTGCAVCVALCPQHVLTTVPKDQKGAIALCSCRNPRKPQIMKNCKRGCIKCMKCEKNCPTGAIKVIDGIPKVDYTLCDSCNKCVEGCPTKVLVLTENKVKFNSCTSCEGCQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LI6</accession>
    <name>Q73LI6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, WecB/TagA/CpsF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972480.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675248.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1876"/>
    <dbReference type="CAZy" id="GT26">
        <property type="family name" value="Glycosyltransferase Family 26"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12391">
        <property type="protein sequence ID" value="AAS12391"/>
        <property type="gene ID" value="TDE_1876"/>
    </dbReference>
    <dbReference type="GeneID" id="2739105"/>
    <dbReference type="KEGG" id="tde:TDE_1876"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1776"/>
    <dbReference type="eggNOG" id="COG1922">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063203_3_1_12"/>
    <dbReference type="OMA" id="KEPRRMW"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="246" mass="28683" checksum="C7831328028248DA" modified="2004-07-05" version="1">MAVKRINFLNVPLDVLHEEDIEETVMSLLNKEGPQQIIFMTIWDVLRARRNGEFRNMVKEAALCLPVSKSLIRGARFLKKDVPVRRQQFSVVIDFLNVIDSHYKSLYLFGGRQESLLVAEKNVRSTFPGLRLVGRFAGYYHKSMEPHIISAISKAAPSVVIIGKGVPGGRKWIYRNKEHFNSGIFIRYANLIDIFSKFKKRPSEKLFNSGWDFIIPVLKNPFRIFTFFGYIWYNILLLFYRLFRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LI8</accession>
    <name>Q73LI8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972478.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1874"/>
    <dbReference type="EnsemblBacteria" id="AAS12389">
        <property type="protein sequence ID" value="AAS12389"/>
        <property type="gene ID" value="TDE_1874"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1874"/>
    <dbReference type="HOGENOM" id="CLU_3298097_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="40" mass="4708" checksum="65327E051E4A9714" modified="2004-07-05" version="1">MLNKIEIFINFVNLCLTDEILDDRLKLDIGGKYKLKKIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LL6</accession>
    <name>Q73LL6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972450.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669606.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1846"/>
    <dbReference type="EnsemblBacteria" id="AAS12361">
        <property type="protein sequence ID" value="AAS12361"/>
        <property type="gene ID" value="TDE_1846"/>
    </dbReference>
    <dbReference type="GeneID" id="2740508"/>
    <dbReference type="KEGG" id="tde:TDE_1846"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1752"/>
    <dbReference type="eggNOG" id="ENOG503344K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176906_0_0_12"/>
    <dbReference type="OMA" id="CDNGCIL"/>
    <dbReference type="OrthoDB" id="2012265at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="85" mass="9696" checksum="0D46E63E9F110703" modified="2004-07-05" version="1">MQAIPVKSYDARIDSKKRITLRNALFEYFNVKEFADGTIVLEPRELTKPFTVSSNTLSMMDKSMENFNFGDVSDPIDISVYGDVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LM9</accession>
    <name>Q73LM9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1777</name>
        <name evidence="2" type="ordered locus">TDE_1833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405</strain>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972381.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972437.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679539.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1777"/>
    <dbReference type="EnsemblBacteria" id="AAS12292">
        <property type="protein sequence ID" value="AAS12292"/>
        <property type="gene ID" value="TDE_1777"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12348">
        <property type="protein sequence ID" value="AAS12348"/>
        <property type="gene ID" value="TDE_1833"/>
    </dbReference>
    <dbReference type="GeneID" id="2741221"/>
    <dbReference type="KEGG" id="tde:TDE_1777"/>
    <dbReference type="KEGG" id="tde:TDE_1833"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1693"/>
    <dbReference type="HOGENOM" id="CLU_1786044_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="145" mass="17201" checksum="61A78549389F4F89" modified="2004-07-05" version="1">MKTNYDALETATKQLSKIEKLFSDVDFRKYLSVKTNISIAANDKIVFFIVTGSRSFYGLDDIKYNIFPIYELLNYIETHEIIFCNRIYSYYDDKISFTENLKNFINDRPNQTCLNRALVKINEKIKIGNKTIYRETFQIDFKNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LQ2</accession>
    <name>Q73LQ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972414.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669589.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12325">
        <property type="protein sequence ID" value="AAS12325"/>
        <property type="gene ID" value="TDE_1810"/>
    </dbReference>
    <dbReference type="GeneID" id="2739240"/>
    <dbReference type="KEGG" id="tde:TDE_1810"/>
    <dbReference type="HOGENOM" id="CLU_1618271_0_0_12"/>
    <dbReference type="OrthoDB" id="2116753at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="164" mass="19730" checksum="304625C1BE2F9779" modified="2004-07-05" version="1">MFSSIILESVKEYIPNSYIENNEKYDFIVGSKVKKKLVFKIIHNYIFIFSRINNNDFSLLIHEISEKIKNIKVKVCIIYIHDFDLVEENNKFLFFIKKCKRVNSFIRINSSNGQVYFSTNKDLENKICSERYVFLLNEYKFAIKNIWQNELNNFYDICFKIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LW8</accession>
    <name>Q73LW8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972348.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679463.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1744"/>
    <dbReference type="TCDB" id="2.A.51.1.6">
        <property type="family name" value="the chromate ion transporter (chr) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12259">
        <property type="protein sequence ID" value="AAS12259"/>
        <property type="gene ID" value="TDE_1744"/>
    </dbReference>
    <dbReference type="GeneID" id="2740589"/>
    <dbReference type="KEGG" id="tde:TDE_1744"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1667"/>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018106_1_0_12"/>
    <dbReference type="OMA" id="WIKEEEF"/>
    <dbReference type="OrthoDB" id="1884249at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="195" mass="21255" checksum="7479941FD8BE2BA6" modified="2004-07-05" version="1">MNKANRFKTYASLFASFFKIGLVTFGGGLAMLPILKRDLVDSKGWLTEDEILDYFAIGQSTPGVIAVNVATFVGYKRGGLIGSIFSTSGIVFPSLIIISLIAAFVSNFNELVWVQKALKGINVAVSVLLVKAVFSFGKKTVFDLCTFLIAALSFVLMFAFKVQGVWIVIGSALSGWLFQTIKSSRLLKKNKGEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M00</accession>
    <name>Q73M00_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar filament outer layer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">flaA</name>
        <name evidence="6" type="ordered locus">TDE_1712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the outer layer of the flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Periplasmic flagellum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972316.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670927.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1712"/>
    <dbReference type="EnsemblBacteria" id="AAS12227">
        <property type="protein sequence ID" value="AAS12227"/>
        <property type="gene ID" value="TDE_1712"/>
    </dbReference>
    <dbReference type="GeneID" id="2740884"/>
    <dbReference type="KEGG" id="tde:TDE_1712"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1637"/>
    <dbReference type="eggNOG" id="ENOG50329D7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821088_0_0_12"/>
    <dbReference type="OMA" id="EDMSGME"/>
    <dbReference type="OrthoDB" id="735776at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006714">
        <property type="entry name" value="FlaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016369">
        <property type="entry name" value="FlaA_Spirochaetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04620">
        <property type="entry name" value="FlaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002892">
        <property type="entry name" value="Flagellin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285973" description="Flagellar filament outer layer protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="349" mass="39289" checksum="1943E7762CAD004A" modified="2004-07-05" version="1">MKKTFILVAMAFLLMGAVAVAEEAIIIDFALLNADIIADPNGKMTQNRRTVMDYGKVAGASYTDEQKALMRTSLALEQWDVELNSSAQNPLSVATSTIKEAEVRAEGEKFAGQKLMGVRILFPEWTNNANAKIKPGFLIPAYEKMAQVDDQGNLQEPTAEDKASGKSRFEDGYGVVRNTGVIKSIAVNTYGMNFPHGLYVLLRDQNNVVKRYFMGYLLFDGWRELVWNNPSYIANVKSRELRLYPVYPTALPHVAFEGFLITRDAAHDGGDAIAYFKDVKIIYDKAVLTTVRDFADEDLWGIQEERETKRKKIEVEKFGHTQVLRFLEQEKMATEEGFTPSEGSEKNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M31</accession>
    <name>Q73M31_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">V-type ATPase, K subunit</fullName>
            <ecNumber evidence="7">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpK</name>
        <name evidence="7" type="ordered locus">TDE_1679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972284.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669353.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1679"/>
    <dbReference type="EnsemblBacteria" id="AAS12195">
        <property type="protein sequence ID" value="AAS12195"/>
        <property type="gene ID" value="TDE_1679"/>
    </dbReference>
    <dbReference type="GeneID" id="2740134"/>
    <dbReference type="KEGG" id="tde:TDE_1679"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1605"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126047_1_0_12"/>
    <dbReference type="OMA" id="IGAWKKC"/>
    <dbReference type="OrthoDB" id="1819847at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="80"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="140" mass="14352" checksum="8A05AFEC3275D155" modified="2004-07-05" version="1">MTFGFFGAAAALGISAIGSAIGLAIAGQSTIGAWKRCYLNNKPAPFSLVAFAGAPLTQTLYGFLLMNRMLTSSQSDWFLLGLGLVCGVSIAASAIAQGKASASGSDAMAETGKGFVQYITIVGLCETVALFVMVFGMMKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M62</accession>
    <name>Q73M62_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972253.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669261.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1647"/>
    <dbReference type="EnsemblBacteria" id="AAS12164">
        <property type="protein sequence ID" value="AAS12164"/>
        <property type="gene ID" value="TDE_1647"/>
    </dbReference>
    <dbReference type="GeneID" id="2739756"/>
    <dbReference type="KEGG" id="tde:TDE_1647"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1574"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136757_0_1_12"/>
    <dbReference type="OMA" id="YAQQENS"/>
    <dbReference type="OrthoDB" id="1851915at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="115" mass="13360" checksum="1BCBAD7690B4DA5F" modified="2004-07-05" version="1">MTTLIDVQFIAGKDGKPEYAVIPFKVFQTLCNHKVREFNEKETIPHEVIKKIHLEDMSSIQAWREYLNLTQTEIAEKMGISQAAYSQMETSKKNRKATLEKIAQAMNIDYLQLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M95</accession>
    <name>Q73M95_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972220.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679301.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1614"/>
    <dbReference type="EnsemblBacteria" id="AAS12131">
        <property type="protein sequence ID" value="AAS12131"/>
        <property type="gene ID" value="TDE_1614"/>
    </dbReference>
    <dbReference type="GeneID" id="2740855"/>
    <dbReference type="KEGG" id="tde:TDE_1614"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1543"/>
    <dbReference type="eggNOG" id="ENOG5032KME">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_747921_0_0_12"/>
    <dbReference type="OrthoDB" id="1636936at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="330" mass="37423" checksum="DDF6DE7C96578920" modified="2004-07-05" version="1">MEFNIKKIPFFLCTLFFLHSLTAQNSLPPNIQKIIKNGFTKKTPADVSSFIEAEIKKVSSNEEKIIALSVLADYEERFDLFLRAGRHYLEAAELSPEKERKTLLTKALGAYLLADNISESSELCHNRLLPIIETPFSKEDIKVLVLFEWLKLKSDEKSSLENIKKYVTDSKFAEFHPAMLLTLWWVDGDKKAENTLIKKFPNSIEAAVVRGEAFLSPKTFWYLMPQNRDFKESLADSASESVSLSQGETLGLAQNNEVPAAKFYQTGFFKTENFAKGLADELKKKGFTVTIKKEERGEDAFFSVLVKDDGKGDMVIRLKSEGYEAVPIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MM8</accession>
    <name>Q73MM8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972086.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678138.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1480"/>
    <dbReference type="EnsemblBacteria" id="AAS11997">
        <property type="protein sequence ID" value="AAS11997"/>
        <property type="gene ID" value="TDE_1480"/>
    </dbReference>
    <dbReference type="GeneID" id="2741595"/>
    <dbReference type="KEGG" id="tde:TDE_1480"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1419"/>
    <dbReference type="eggNOG" id="ENOG502ZYHU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143566_1_0_12"/>
    <dbReference type="OMA" id="FSHVRLY"/>
    <dbReference type="OrthoDB" id="1569941at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="139" mass="16050" checksum="5FA67D62CB7AAFDA" modified="2004-07-05" version="1">MKKSILSLVFLVLIFSLFTIAPAFSQKIEEADVYYVNVQILKIFTHSDGYYIIYRRAGLKHAEVFIPKSWLDPKDGRARLELVNTRVNPYLSFYLKDGKFDRIKIAAPRDLGSPIWGVLKDPNKYNGKFDGVESLELKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MS6</accession>
    <name>Q73MS6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972037.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1431"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11948">
        <property type="protein sequence ID" value="AAS11948"/>
        <property type="gene ID" value="TDE_1431"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1431"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1372"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_0_12"/>
    <dbReference type="OMA" id="WIHTDYS"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="41"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="231"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="498" mass="57656" checksum="5975AB9CBAB1E96F" modified="2004-07-05" version="1">MHGRIKYVFLVTDKSRCIFNKMNNQKKTKLLFITYTHSNGGGAEKVLTTLVNNLDTKKYEIAIQEIVGFYVKQEPISSNIKLLTPLINGTHESRFNKHFTQYCIEKYPVLIRAIKSFDEYDVIVTWNYQIPSFMIQAFPDKKTISWFHTDIYDLSPKLMSLNDKYNLKLQDSAWNYADRIVTISNKSLQSLKDIFPQYLNKTKIIYNAFDIENTKVQASKVNINECMRYTYPILACVGRLEKRKNFSLVIQAAAKLQKENICCHVLIIGDGEEKGNLIRLVNELRMTEVVSFLGYKQNPLPYIQIADMLCISSFAEGFPTVVLEAMTLEKPFVTTPVAGASEELADNGNCGLVADWDVDDYAEKIKTLLTDKDLYDRMSKNCIKKIKEFSIENTVIRFDELVSSLPEKGNSGFRRIDKATAVKKIRRAYIWCPNFAIQRLRFSISTFFMKPSIRNFALTGYYFLRLLFYIPTLPIRFFTQPAILQRSENHFKDEKCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MY6</accession>
    <name>Q73MY6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="16">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="16">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="16">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">nnrE</name>
        <name evidence="14" type="synonym">nnrD</name>
        <name evidence="18" type="ordered locus">TDE_1370</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15 16">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 16">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 16">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15 16">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="16"/>
    <dbReference type="EC" id="5.1.99.6" evidence="16"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971976.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678947.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1370"/>
    <dbReference type="EnsemblBacteria" id="AAS11887">
        <property type="protein sequence ID" value="AAS11887"/>
        <property type="gene ID" value="TDE_1370"/>
    </dbReference>
    <dbReference type="GeneID" id="2741131"/>
    <dbReference type="KEGG" id="tde:TDE_1370"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1316"/>
    <dbReference type="eggNOG" id="COG0062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_2_12"/>
    <dbReference type="OMA" id="HNGGDAL"/>
    <dbReference type="OrthoDB" id="1748633at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12 14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="17">
        <location>
            <begin position="8"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="401"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AAS11887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="496" mass="54145" checksum="B24B9483C0679AF0" modified="2004-07-05" version="1">MQNVFYSLRELDKRAEEDFNLKNGILMENAARGSAEKIKNLFPLKKRDEKKTLQIVCGSGDNGGDGLALARILADDFNIHVIILKEPKSELCKLQYERLKALNIRTAKNILPESDILFDAFLGTGLKGLLKAEDKKTIEKINKVKAFKIACDIPSGLNLDGEASPNAVLCNMTFSMGALKQAFYSDEAKDITGKIEVIDLGLPRSLYEQNEKSNVFLLEKEDMLLPSRKKQNTHKGSFGHAGIIVGEKNGAALLAASAALEFGAGLVTLIGENRERPKNLKADFMYDGKFEAGKFNVKKFTSIAIGQGLGRKNDGLFSILKVKETQSMPMVIDADIFYYAELKKILPELSAAVLTPHPKEFSSLLNIAGFGSLSIEEIQKKRFILALSFSKKFPKLVLVLKGANTLIAHNGKICINTLGSPSLSKAGSGDVLTGLICSLLAQGYKPLDAAITGSLAHSLASQNSRASYSLTASKLIKNLEKLEAEQFKESKARQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N08</accession>
    <name>Q73N08_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678909.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73N08"/>
    <dbReference type="STRING" id="243275.TDE_1348"/>
    <dbReference type="EnsemblBacteria" id="AAS11865">
        <property type="protein sequence ID" value="AAS11865"/>
        <property type="gene ID" value="TDE_1348"/>
    </dbReference>
    <dbReference type="GeneID" id="2739449"/>
    <dbReference type="KEGG" id="tde:TDE_1348"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1296"/>
    <dbReference type="eggNOG" id="COG2976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073066_0_0_12"/>
    <dbReference type="OMA" id="KSDLVLW"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="311" mass="35839" checksum="EE6267D513B99DA0" modified="2004-07-05" version="1">MEFSKGRSHKNFSNKKRSFKKILIVLLFLLCVTSAVYFLYIYNKNYAGIPSMKEVYADWAEKNYESVYQKTASILKRRAYDGEALAMRGFASYYIFAEQTDFSVSYSYLNDSILNLRQAMYCVSKSQQPKIAYVLGKAYYQKGYYYADLALKYLDIAYNSGEKFADLSEFRGMSASLLGEPERAIDAFSDALSHNPSDLLFFALAENYIKISDKQNAKLYLFETIDKTKDTLLELKCRYLLGSLFLEENKIDDAVKEFNTILEKDMTSADAHYGLGVVYELQGDMIKARAEWRKALKFDPLHVKTRAKLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N96</accession>
    <name>Q73N96_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid carrier family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_1259</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.</text>
    </comment>
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        <property type="protein sequence ID" value="AAS11777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971866.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956936.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1259"/>
    <dbReference type="EnsemblBacteria" id="AAS11777">
        <property type="protein sequence ID" value="AAS11777"/>
        <property type="gene ID" value="TDE_1259"/>
    </dbReference>
    <dbReference type="GeneID" id="2741435"/>
    <dbReference type="KEGG" id="tde:TDE_1259"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1211"/>
    <dbReference type="eggNOG" id="COG1115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024867_1_0_12"/>
    <dbReference type="OMA" id="ILMAPEY"/>
    <dbReference type="OrthoDB" id="883596at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001463">
        <property type="entry name" value="Na/Ala_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30330">
        <property type="entry name" value="PTHR30330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01235">
        <property type="entry name" value="Na_Ala_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00175">
        <property type="entry name" value="NAALASMPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00835">
        <property type="entry name" value="agcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00873">
        <property type="entry name" value="NA_ALANINE_SYMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="474" mass="50848" checksum="2F6C1B23E463B848" modified="2004-07-05" version="1">MEQFLQNLTSLVSSANGFIWGVYFLIPLLCGTGLFFTIRLGGVQFTKFGAGWKRLFGNFSLSGKEAGKHGMSSFQAVATAIAAQVGTGNLVGAMTALIMGGPGAIFWMWLAALAGMATNFAEASIAQIYKTKDDSGQTVGGPAYYISAGLKNKVGEGFAKFLAGFFAIAIILALGFMGNMVQANSISDAFQNAFHIPTWVTGAVLAVIAGIIFMGGVKRIASVTEKVVPIMAIVYIVVGLIVIIINAAQIPEMFAMIFKGAFNPRAVWGGALGFGMGRAVRYDVARGLFSNEAGMGSTPHAHAVADVKHPVEQGVLGIVAVFIDTFIVLNITVFTVLSSGIVQFEGGEATMKGIKLVQEAFAQHLFGSTFGYLFIAICLFFFAFSTIIGWYYFGETNIRYLFGTKGLIPYQLLVIIFIFVGSLLKIDLVWELTDFFNGIMVIPNLIALLFLSGTVAKVLKDYNKGLPYDASQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NB2</accession>
    <name>Q73NB2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemolysin C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tlyC</name>
        <name evidence="5" type="ordered locus">TDE_1243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971850.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678735.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1243"/>
    <dbReference type="EnsemblBacteria" id="AAS11761">
        <property type="protein sequence ID" value="AAS11761"/>
        <property type="gene ID" value="TDE_1243"/>
    </dbReference>
    <dbReference type="GeneID" id="2741185"/>
    <dbReference type="KEGG" id="tde:TDE_1243"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1195"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_3_0_12"/>
    <dbReference type="OMA" id="QMISIKA"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="108"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="258" mass="29272" checksum="4A0481D78170E9A6" modified="2004-07-05" version="1">MGIIDLFKKKGNVNNILKEGLNEEKRDMIRGVVDLSDTAVKEVMIPRIDVDFLALDTPSDEILDRISESGHSRFPVYDESIDNVIGILYVKDIIKLLTKNQKIELDKIVRRAFFVPESKRIDALLAEFKRRHIHIAVAVDEYGGVSGIVCMEDIIEEIVGDIQDEFDNEGEDITEIAPGVWLCDARVDLDDLAETIKSDDLPVDEFETLGGFVFDLFGKIPAKYEKTAWNDFDFIVQDMDGHKVKTVKIVHNKNSMQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ND8</accession>
    <name>Q73ND8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar assembly protein fliH, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971824.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668471.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1217"/>
    <dbReference type="EnsemblBacteria" id="AAS11735">
        <property type="protein sequence ID" value="AAS11735"/>
        <property type="gene ID" value="TDE_1217"/>
    </dbReference>
    <dbReference type="GeneID" id="2740111"/>
    <dbReference type="KEGG" id="tde:TDE_1217"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1172"/>
    <dbReference type="eggNOG" id="COG1317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077967_0_0_12"/>
    <dbReference type="OMA" id="CIIETDF"/>
    <dbReference type="OrthoDB" id="1285795at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018035">
        <property type="entry name" value="Flagellar_FliH/T3SS_HrpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02108">
        <property type="entry name" value="FliH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FliH" evidence="3">
        <location>
            <begin position="162"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="308" mass="35008" checksum="0A9B60A60F0AFDF3" modified="2004-07-05" version="1">MAKTIFRGFEVNKNNNDVVFLQLNKTFQEEPEEIIEEKVPVYEGPTVEDLKKEAEDFKLEWEKQKEKMISDAKAEADKIIEDAQNAAFDEVKRQTDEAQVIAQNAKKDAEDIIAEAEQKARDIIADSEKNKDSVNRDAYKEGFNRGREEGFKEGNLEVQRLTDRLHTIINKTMDRRQEILSETEQQIVDLVLLMTRKVVKVISENQRNVVVSNVVHALRKVKGRGDVVIRVNLADVKMTTEHIQNFISAAENIKNITVVEDSTVDQGGCIIETDFGAVDARIASQLNELEQKILEISPIKTKIKTGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NE0</accession>
    <name>Q73NE0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Flagellar M-ring protein FliF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fliF</name>
        <name evidence="14" type="ordered locus">TDE_1215</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliF family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971822.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678706.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1215"/>
    <dbReference type="EnsemblBacteria" id="AAS11733">
        <property type="protein sequence ID" value="AAS11733"/>
        <property type="gene ID" value="TDE_1215"/>
    </dbReference>
    <dbReference type="GeneID" id="2740109"/>
    <dbReference type="KEGG" id="tde:TDE_1215"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1170"/>
    <dbReference type="eggNOG" id="COG1766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028108_2_0_12"/>
    <dbReference type="OMA" id="NYEVNRI"/>
    <dbReference type="OrthoDB" id="167675at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009431">
        <property type="term" value="C:bacterial-type flagellum basal body, MS ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013556">
        <property type="entry name" value="Flag_M-ring_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000067">
        <property type="entry name" value="FlgMring_FliF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046:SF0">
        <property type="entry name" value="PTHR30046:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08345">
        <property type="entry name" value="YscJ_FliF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01009">
        <property type="entry name" value="FLGMRINGFLIF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00206">
        <property type="entry name" value="fliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="12">
        <location>
            <begin position="64"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF_C" evidence="13">
        <location>
            <begin position="260"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAS11733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="567" mass="64762" checksum="F07CEF95A13B7EAB" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NE4</accession>
    <name>XERC_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xerC</name>
        <name type="ordered locus">TDE_1209</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971816.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678705.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NE4"/>
    <dbReference type="SMR" id="Q73NE4"/>
    <dbReference type="STRING" id="243275.TDE_1209"/>
    <dbReference type="EnsemblBacteria" id="AAS11727">
        <property type="protein sequence ID" value="AAS11727"/>
        <property type="gene ID" value="TDE_1209"/>
    </dbReference>
    <dbReference type="GeneID" id="2740103"/>
    <dbReference type="KEGG" id="tde:TDE_1209"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1164"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_2_12"/>
    <dbReference type="OMA" id="HSFASHM"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0229">DNA integration</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000070047" description="Tyrosine recombinase XerC">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Core-binding (CB)" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="1">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <sequence length="305" mass="35185" checksum="8A795654E45D0F5C" modified="2004-07-05" version="1">MNEVFESYLTYSAGVRQFTKATIDSYKNDLIIFEEWLKELDLNIFELKASDIRIFIAELADKKIAPASINRMMSTLRGFYKYALRFNLTKMNPISSVRNLKLAQKLPVFMFPKQAQEFCRLPSNAGILWETRDAALFASLYSTGCRVSELAGLDIKDLDKTLSYAIVFGKGKKERKVFFAEFAKEYLREYLKERSDLVEKFKGQVQKDGKGKIRDTLFINQKAQPLTSRGIRYIIDRYVELSPELKHLSPHAFRHSFASTLITRGADIRVVQELLGHESVSTTQRYTHITAEQLQNLYKTAHPHS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NF6</accession>
    <name>MRAZ_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraZ</name>
        <name type="ordered locus">TDE_1197</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971804.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678680.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NF6"/>
    <dbReference type="SMR" id="Q73NF6"/>
    <dbReference type="STRING" id="243275.TDE_1197"/>
    <dbReference type="EnsemblBacteria" id="AAS11715">
        <property type="protein sequence ID" value="AAS11715"/>
        <property type="gene ID" value="TDE_1197"/>
    </dbReference>
    <dbReference type="GeneID" id="2741158"/>
    <dbReference type="KEGG" id="tde:TDE_1197"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1152"/>
    <dbReference type="eggNOG" id="COG2001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107907_0_2_12"/>
    <dbReference type="OMA" id="RGQERCL"/>
    <dbReference type="OrthoDB" id="1684767at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000108551" description="Transcriptional regulator MraZ">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 2" evidence="2">
        <location>
            <begin position="77"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <sequence length="144" mass="16410" checksum="8E76AF49D8A8A64E" modified="2004-07-05" version="1">MTGEYKNTLDEKGRIMFPAKIRAELPDSNLVITRGVGNCLWIFTADKWKKFSDEIMKKTSLFKAQSLLVMRRLIAPAQEIEVDKNGRISIPQSLRECAGLEKDCIILGLGKCFELWDLKQYEKYLKESEPDFSEAAEALGEIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NI3</accession>
    <name>Q73NI3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage DNA-binding protein, excisionase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971777.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956915.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1169"/>
    <dbReference type="EnsemblBacteria" id="AAS11658">
        <property type="protein sequence ID" value="AAS11658"/>
        <property type="gene ID" value="TDE_1169"/>
    </dbReference>
    <dbReference type="GeneID" id="2740066"/>
    <dbReference type="KEGG" id="tde:TDE_1169"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1127"/>
    <dbReference type="eggNOG" id="COG3311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140176_0_3_12"/>
    <dbReference type="OMA" id="TCKYLEL"/>
    <dbReference type="OrthoDB" id="2076478at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="3"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="81" mass="9685" checksum="6037253672523644" modified="2004-07-05" version="1">MIMNMKQVMELTGYTQSYIYNLVHKKMIPVYKPNGGRLFFVKEEIEQWLLGGRQMTSEEMHKEADKMLLDMAARRSKRRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NJ4</accession>
    <name>Q73NJ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage terminase, small subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971766.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956905.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1158"/>
    <dbReference type="EnsemblBacteria" id="AAS11647">
        <property type="protein sequence ID" value="AAS11647"/>
        <property type="gene ID" value="TDE_1158"/>
    </dbReference>
    <dbReference type="GeneID" id="2741490"/>
    <dbReference type="KEGG" id="tde:TDE_1158"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1117"/>
    <dbReference type="eggNOG" id="ENOG5030Y67">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1348430_0_0_12"/>
    <dbReference type="OMA" id="CIDSINE"/>
    <dbReference type="OrthoDB" id="1645100at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038713">
        <property type="entry name" value="Terminase_Gp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005335">
        <property type="entry name" value="Terminase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03592">
        <property type="entry name" value="Terminase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="203" mass="22988" checksum="255EB4F980C94DE1" modified="2004-07-05" version="1">MAKIAKAKDESKAKIKPKVEDWAEELNEQQRLFVLYYCTDEWCFLNGTLAYRKAYPKCKSDEAAATGASKLLRIAKVKKSARSLLKLTRELDDELTAYKILKTYEHLAFYNPADIITNTGELLKPLKELGPLAICVEQIQTFYTKDGAPCTVVKLANRHKALTVLMKYLSLVKPEINMEAMMPVAMISDKTSIAEWQTETKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NS9</accession>
    <name>Q73NS9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971681.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670594.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1073"/>
    <dbReference type="TCDB" id="3.A.1.5.47">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11562">
        <property type="protein sequence ID" value="AAS11562"/>
        <property type="gene ID" value="TDE_1073"/>
    </dbReference>
    <dbReference type="GeneID" id="2740834"/>
    <dbReference type="KEGG" id="tde:TDE_1073"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1033"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_12"/>
    <dbReference type="OMA" id="TFVVIQF"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="BRENDA" id="7.4.2.9">
        <property type="organism ID" value="6426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="119"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="346" mass="39096" checksum="BE7215A2B5D3E4D4" modified="2004-07-05" version="1">MYKWYALKRILRGVVIYSILIFIFSFLFNQINEKVQRSQIMEMVRAEAKGLKNMTAEQIMAWRKDQELTLIRQYKLDRPLVERVLHNAKRVLTFDFGKSTTIKSLTGSQEVIKILGEAIPRTLLLFTTAFVINTLIGLALGLKKAQKPGSRLDKTTSLITLIIYGMPSWWLAMLLIFVFVYKIPLFPSGGVNSVPVPEGIWFVFDRLQHLALPILTLVFLGFWSTAYVIRNLVLGTLQEDFIMSARARGIPEKKVLHGHTLRTSAPPLVTMILLSFLASMSGSIIYEGIFSWPGLGQLYWIAVQQNDIPVLMGDLAITTGLYQAGLIILDLVYGFLDPRIKVGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NV9</accession>
    <name>Q73NV9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971651.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670521.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1043"/>
    <dbReference type="EnsemblBacteria" id="AAS11532">
        <property type="protein sequence ID" value="AAS11532"/>
        <property type="gene ID" value="TDE_1043"/>
    </dbReference>
    <dbReference type="GeneID" id="2741317"/>
    <dbReference type="KEGG" id="tde:TDE_1043"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1003"/>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028799_3_0_12"/>
    <dbReference type="OMA" id="PYSSKQY"/>
    <dbReference type="OrthoDB" id="1558251at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="377" mass="42205" checksum="822184B7611E1207" modified="2004-07-05" version="1">MRGLSFNHKTIFVYVFKELLLYFIVSFLFFFFIFFVNQILLMAEEILSKKAPTKDVLLLLFYSLPFIIATTAPYAALIGTLMCLGRFSADHEFISMNALGISTSFILIPVFALGVFVSVGSFITNDILIPRGTIKFNEVLYNIASSTPALELESYSVKRNENSIVVSGLIKDNSIHDLLIIDSSQRGAKRFLSSSQTDVKKSNDRSIIMQLEMLNPRLLNLDLNNRSKFDVVYGESITYNVLAKDVAPKFISSSGPDKMTSYDLIKDIKQKKEAGDTSPRLLNIYIMELHRKFSVPFGAFFFVLLAFAISRAGKTYDQSTGFIVGLLISVAYWAFLIGGQMLCLESGLNINGALVMWFPNVLLVICTAVIAIKRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NZ9</accession>
    <name>Q73NZ9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrE</name>
        <name evidence="6" type="ordered locus">TDE_1001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971610.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682319.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1001"/>
    <dbReference type="EnsemblBacteria" id="AAS11491">
        <property type="protein sequence ID" value="AAS11491"/>
        <property type="gene ID" value="TDE_1001"/>
    </dbReference>
    <dbReference type="GeneID" id="2739078"/>
    <dbReference type="KEGG" id="tde:TDE_1001"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.961"/>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_1_1_12"/>
    <dbReference type="OMA" id="ENPFTWA"/>
    <dbReference type="OrthoDB" id="1280396at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="54"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="138"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="234" mass="25762" checksum="8894316B77198E0B" modified="2004-07-05" version="1">MHKDEKKIAEVQKKYGALLAKTAFELGALKLSPNEPFTWASGYRMPIYNDNRRFLALPEMRRTIAEAFAELLKAVDFDPEWLAGTATAGIPHSVSLGDLLQKSVSYVRSGGKDHGLKNQIEGLGANADYKGADVLVVEDLISTGGSSIKAVEAVRNANGKVPFCFAIFSYGFAEAEKAFAELKPSCIPVTILNYDIMLDEAVKQNYISEENKKSLGEWRLDPFGWGEKHGFPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P02</accession>
    <name>Q73P02_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971607.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11488">
        <property type="protein sequence ID" value="AAS11488"/>
        <property type="gene ID" value="TDE_0998"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0998"/>
    <dbReference type="HOGENOM" id="CLU_2756616_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="70" mass="7963" checksum="0EEBBD9684919C44" modified="2004-07-05" version="1">MVKSFSYVLAIKSFLKIVYYDYTLKAVFLKVIGGKNSNFGLKKKNDFGPQRDLDFLKMYNPRVSAGCTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P25</accession>
    <name>Q73P25_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971584.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0974"/>
    <dbReference type="EnsemblBacteria" id="AAS11465">
        <property type="protein sequence ID" value="AAS11465"/>
        <property type="gene ID" value="TDE_0974"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0974"/>
    <dbReference type="HOGENOM" id="CLU_3384319_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="33" mass="3736" checksum="93D60B403BE7E194" modified="2004-07-05" version="1">MAENEGGETTTEINAIKLHRIKQRSPQGTRRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P49</accession>
    <name>Q73P49_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971560.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0950"/>
    <dbReference type="EnsemblBacteria" id="AAS11441">
        <property type="protein sequence ID" value="AAS11441"/>
        <property type="gene ID" value="TDE_0950"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0950"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.914"/>
    <dbReference type="HOGENOM" id="CLU_3158997_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="48" mass="5906" checksum="C2178B3A75B37A61" modified="2004-07-05" version="1">MADNIAKKREEFKMGRLFYNPFTYALKYKYKIFIIVNIKIHTFPIRHP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P66</accession>
    <name>ACKA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetate kinase</fullName>
            <ecNumber evidence="1">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ackA</name>
        <name type="ordered locus">TDE_0933</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971543.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956840.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73P66"/>
    <dbReference type="SMR" id="Q73P66"/>
    <dbReference type="STRING" id="243275.TDE_0933"/>
    <dbReference type="EnsemblBacteria" id="AAS11424">
        <property type="protein sequence ID" value="AAS11424"/>
        <property type="gene ID" value="TDE_0933"/>
    </dbReference>
    <dbReference type="GeneID" id="2740966"/>
    <dbReference type="KEGG" id="tde:TDE_0933"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.901"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_12"/>
    <dbReference type="OMA" id="KIITCHI"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword id="KW-0479">Metal-binding</keyword>
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            <position position="148"/>
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        <location>
            <position position="7"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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            <position position="14"/>
        </location>
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        <location>
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            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
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            <end position="285"/>
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    </feature>
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            <end position="335"/>
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        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <sequence length="397" mass="43539" checksum="D186D665604ED3E6" modified="2004-07-05" version="1">MKILVINCGSSSLKYQLIDMTNEDVLVKGLVERIGIEGSRIKHEKKGMDAVLIEEKMNDHKRAIQLVLEALIDKNHGVVKSMDEITAVGHRVVHGGEEFNKSVLLDDRVMAGIKECIDLAPLHNPANIMGIEACKALMPKTPMVAVFDTAFHQTMPAENYIYALPYEYYEKYKIRRYGFHGTSHRFVSEKASETLKNNSADFKVITCHLGNGSSLAAIKGGKCVDTSMGLTPLEGLVMGTRSGDLDPAILPFIMNKEKLSADEMSNVLNKKSGVFGISGVSSDFRDIETAAKEGNKRAQLALDVFCNRVRKYIASYAAQLGGVDALVFTAGIGENSIELREKICHGLEFLGVELDSEKNKVRGKLTDASKASSKVKVLIIPTNEELMIAKDTMALVK</sequence>
</entry>
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            <fullName evidence="4">Adenylate/guanylate cyclase catalytic domain protein</fullName>
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        <name evidence="4" type="ordered locus">TDE_0932</name>
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    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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            <end position="39"/>
        </location>
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            <end position="811"/>
        </location>
    </feature>
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            <end position="904"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="936" mass="106385" checksum="1FD8C626A44D138F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Tettelin H."/>
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                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="345"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="377"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="581" mass="65302" checksum="CDD3F740229B004B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P94</accession>
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            <fullName evidence="6">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ordered locus">TDE_0905</name>
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    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <dbReference type="EnsemblBacteria" id="AAS11396">
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        <property type="gene ID" value="TDE_0905"/>
    </dbReference>
    <dbReference type="GeneID" id="2739945"/>
    <dbReference type="KEGG" id="tde:TDE_0905"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.876"/>
    <dbReference type="eggNOG" id="COG0619">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProt"/>
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        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
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        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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            <end position="43"/>
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            <end position="237"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS11396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="238" mass="26777" checksum="487D2D2DAF05470F" modified="2004-07-05" version="1">MQKIKTTVDVRTLLFLDIVIMVFMLISGKAEVTLCSFIVAAAVPVITGLYGVLLCYTVLFAVLFFYYQVILHLHFPMFQSAVFSVIGILAFIVQRIIPFTLLGTVIQKQKNISEITMALDRMRLPRGVILSIAVMFRYFPAIKDDFLIIIDAMKLKGLYTSKCAAILHPIRTMEFIIVPMLFKSLKTVEELSCAALVKGIENTDKKTSYFDVKLRPIDAVFPLAAIIVLTASMYAKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PF6</accession>
    <name>Q73PF6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">TDE_0843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    <dbReference type="GeneID" id="2739620"/>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.812"/>
    <dbReference type="eggNOG" id="ENOG5033THS">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813628_0_0_12"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="341" mass="37726" checksum="4D94F1C667C75FF1" modified="2004-07-05" version="1">MVNMTNFFVPLAKKTDFNVSVKHIQSVIEILEDCDPKENIADKINLMIREQTIKPEQVRSILSVSLLDKWNYKVVSENLKFILDDASSFVAEVAKWSGIDLVFGYDHPDLGFIVINPKNPAAAQVIQGFRKNELLLIFVGKQDRGSVDAGLADSVISAIHKLFEKKACSVPASVKAGPFVYVEPKKAAPVKVKKAVTKKPGKKNKAASAPVKVQASSVPSHLERPSAVATGPKKMSQLVSVPVSNELFHNGNVEAWKRIIRSYTAKYQDAEVMVYYDGERIVDINTLFKWGKVKHGSTIQFAVSAAEINDLSKLSKYFRQGASPMFEAFLRGSPDTVLNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PF7</accession>
    <name>Q73PF7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic filament protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cfpA</name>
        <name evidence="2" type="ordered locus">TDE_0842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_002672116.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0842"/>
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    </dbReference>
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    <dbReference type="KEGG" id="tde:TDE_0842"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.811"/>
    <dbReference type="eggNOG" id="ENOG5033SJ6">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="682" mass="78512" checksum="67C0103B48966511" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PM1</accession>
    <name>RL24_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplX</name>
        <name type="ordered locus">TDE_0778</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971388.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670017.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PM1"/>
    <dbReference type="SMR" id="Q73PM1"/>
    <dbReference type="STRING" id="243275.TDE_0778"/>
    <dbReference type="EnsemblBacteria" id="AAS11269">
        <property type="protein sequence ID" value="AAS11269"/>
        <property type="gene ID" value="TDE_0778"/>
    </dbReference>
    <dbReference type="GeneID" id="2740656"/>
    <dbReference type="KEGG" id="tde:TDE_0778"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.751"/>
    <dbReference type="eggNOG" id="COG0198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093315_2_3_12"/>
    <dbReference type="OMA" id="HVKPTQE"/>
    <dbReference type="OrthoDB" id="2040741at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000241683" description="50S ribosomal protein L24">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <sequence length="104" mass="11531" checksum="622735AB81C10F0D" modified="2004-07-05" version="1">MAGKMKIRRNDSVEIIAGKERGKRGEVVKVLQEDNKVIVGGLNMIKKAMRKRSQQDQGGIVEIEAPISASNVMVICKKCGKTRIAYEIKDGKKTRICRKCGEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PQ8</accession>
    <name>Q73PQ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971350.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0739"/>
    <dbReference type="EnsemblBacteria" id="AAS11231">
        <property type="protein sequence ID" value="AAS11231"/>
        <property type="gene ID" value="TDE_0739"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0739"/>
    <dbReference type="HOGENOM" id="CLU_3085894_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="52" mass="6043" checksum="8577928328581074" modified="2004-07-05" version="1">MIAEEILIPIESQIRSKLILSFCVIFADIVVIYNTSYYNVIHKLPKIKYPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PT4</accession>
    <name>Q73PT4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971324.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0712"/>
    <dbReference type="TCDB" id="2.A.79.1.5">
        <property type="family name" value="the threonine/serine exporter (thre) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11205">
        <property type="protein sequence ID" value="AAS11205"/>
        <property type="gene ID" value="TDE_0712"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0712"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.689"/>
    <dbReference type="eggNOG" id="COG2966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070277_0_0_12"/>
    <dbReference type="OMA" id="ITRLCIQ"/>
    <dbReference type="OrthoDB" id="1425894at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE" evidence="2">
        <location>
            <begin position="16"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="260" mass="28206" checksum="44649BA3CB30A4C2" modified="2004-07-05" version="1">MRKIMEEEKNSALIFRIALAAGELLIKNGAEMHRTEETILRICSSHGITGLAVFITPTVILIGNDKKEGSTYIKNIKVRGSNIHKISLVNEFSRNFTQGKISENEALEILKNIDAEKNYPYWLVLTTSGIGCGLFSVLLGGTLNDFIVTFIATFAAVFLNDRITQFSKTVFLGNFIAGFFVGIITILFYHIGFVKNLDMIIVGAVLSLVPGVAFTSGIRDFILGDLVSGIARTSEAVLIAVAIAFGIGSVLFSYSLLGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PU4</accession>
    <name>Q73PU4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971314.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681925.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0702"/>
    <dbReference type="EnsemblBacteria" id="AAS11195">
        <property type="protein sequence ID" value="AAS11195"/>
        <property type="gene ID" value="TDE_0702"/>
    </dbReference>
    <dbReference type="GeneID" id="2739824"/>
    <dbReference type="KEGG" id="tde:TDE_0702"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.680"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="CEGYRRP"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="241" mass="25969" checksum="06E279F97206332D" modified="2004-07-05" version="1">MSAIVTAQLTKKYGGITAVDNLNLTVEQGELFALLGVNGAGKTTTIKMLSCLIKPTSGDALLLGNSIISASHAIKKKINISPQETAVAANLSVLENLELIAGIYGQDSKTAKKNAYEIAQKFKLENELNKKAKHLSGGMQRRLSIAMALISDPQILFLDEPTLGLDVLARRELWASIKELKGKVTIILTTHYMDEVETLSDRVGIMSKGKLKAMGTVQELTMQTDTVKLEDAFVILSGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PV4</accession>
    <name>Q73PV4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971304.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0692"/>
    <dbReference type="EnsemblBacteria" id="AAS11185">
        <property type="protein sequence ID" value="AAS11185"/>
        <property type="gene ID" value="TDE_0692"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0692"/>
    <dbReference type="HOGENOM" id="CLU_218470_0_0_12"/>
    <dbReference type="OrthoDB" id="2205738at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="42" mass="4914" checksum="AD1ECA5CE2BF4865" modified="2004-07-05" version="1">MINSSAEIQPHCLSIEFCALHKTSYYCMRFVNKPLEKTFFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PY2</accession>
    <name>Q73PY2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971276.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677040.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0663"/>
    <dbReference type="EnsemblBacteria" id="AAS11157">
        <property type="protein sequence ID" value="AAS11157"/>
        <property type="gene ID" value="TDE_0663"/>
    </dbReference>
    <dbReference type="GeneID" id="2739211"/>
    <dbReference type="KEGG" id="tde:TDE_0663"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.643"/>
    <dbReference type="eggNOG" id="COG3077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154558_16_1_12"/>
    <dbReference type="OrthoDB" id="2086657at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="85" mass="9866" checksum="09F9855E917F9B4E" modified="2004-07-05" version="1">MAQINVNIRMDSEVKQEAEQLFDSLGMNMTTAFNIFIRQSLRIGGIPFKIISDERGFYNKYNQKKLHAAAKRMNEGKYIVHDIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PY7</accession>
    <name>Q73PY7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_0658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971271.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681853.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0658"/>
    <dbReference type="EnsemblBacteria" id="AAS11152">
        <property type="protein sequence ID" value="AAS11152"/>
        <property type="gene ID" value="TDE_0658"/>
    </dbReference>
    <dbReference type="GeneID" id="2739206"/>
    <dbReference type="KEGG" id="tde:TDE_0658"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.638"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022800_2_3_12"/>
    <dbReference type="OMA" id="SGIIVLY"/>
    <dbReference type="OrthoDB" id="366413at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027022">
        <property type="entry name" value="ABC_permease_BceB-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018968">
        <property type="entry name" value="ABC_permease_BceB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="638"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="85"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="681" mass="78442" checksum="4E4A6EC9D3A5898C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q11</accession>
    <name>Q73Q11_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-alanyl-D-alanine carboxypeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971247.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681821.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0633"/>
    <dbReference type="EnsemblBacteria" id="AAS11128">
        <property type="protein sequence ID" value="AAS11128"/>
        <property type="gene ID" value="TDE_0633"/>
    </dbReference>
    <dbReference type="GeneID" id="2739358"/>
    <dbReference type="KEGG" id="tde:TDE_0633"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.611"/>
    <dbReference type="eggNOG" id="COG1876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054193_4_0_12"/>
    <dbReference type="OMA" id="ERYDIYL"/>
    <dbReference type="OrthoDB" id="1593541at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003709">
        <property type="entry name" value="Pept_M15B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02557">
        <property type="entry name" value="VanY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VanY" evidence="1">
        <location>
            <begin position="111"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="266" mass="31935" checksum="0882783BFA7F7B92" modified="2004-07-05" version="1">MYFTPKKIFSLFLFFAFMFFIYPNDKISDEDIYKKVYTYISKRFPKQIFNKINNNREIFFKDLNVVLKNEKEDELILVDKLNFLDKSYEPKNIILLYDVKDRKYLLERYDIYLAKIAERPLQKLAEAAKKEGIEIMISSGYRSYIYQANLFSKYVNVYGKKDVQFFSAPPGASQHQLGTVIDLGSIDDSYADTAEGKWMFKNAWKYGWSLSYPKDMEHITGYKWESWHYRYLGVEACKFQKEWFGDIQQYMLEFIDLWKKEKAKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q20</accession>
    <name>Q73Q20_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Precorrin-6X reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0624</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971238.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681810.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0624"/>
    <dbReference type="EnsemblBacteria" id="AAS11119">
        <property type="protein sequence ID" value="AAS11119"/>
        <property type="gene ID" value="TDE_0624"/>
    </dbReference>
    <dbReference type="GeneID" id="2740469"/>
    <dbReference type="KEGG" id="tde:TDE_0624"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.602"/>
    <dbReference type="eggNOG" id="COG2099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068627_0_0_12"/>
    <dbReference type="OMA" id="THPFAIN"/>
    <dbReference type="OrthoDB" id="1726104at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016994">
        <property type="term" value="F:precorrin-6A reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003723">
        <property type="entry name" value="Precorrin-6x_reduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36925">
        <property type="entry name" value="PTHR36925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02571">
        <property type="entry name" value="CbiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00715">
        <property type="entry name" value="precor6x_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51014">
        <property type="entry name" value="COBK_CBIJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="252" mass="28240" checksum="571D55EFFB4E14DA" modified="2004-07-05" version="1">MIWIIGGTTEAGSLADFLKAKNEPYIMSVATEESRDFFKNHKLKIGRMDALQMEQFCIEEKISLIADLSHPYALIVSQNAKKTAQNLNLKYLRFTRGTSQSSTDLEQNNFYIFEDMEGLCSFLKELKSSTVFFTTGSKTVSDFEAFRSSNRFVYRILPTADSIEKCKNAGVATQDIIAMTGPFSQNLNEAMFKEYGASYIVMKDSGDAGGTREKLAACEALNIKALILGRGKEEGIIEFEEFKKEVLKYGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q53</accession>
    <name>Q73Q53_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA carboxylase, biotin carboxylase</fullName>
            <ecNumber evidence="7">6.4.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">accC</name>
        <name evidence="7" type="ordered locus">TDE_0591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.4.1.2" evidence="7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971205.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681761.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0591"/>
    <dbReference type="EnsemblBacteria" id="AAS11086">
        <property type="protein sequence ID" value="AAS11086"/>
        <property type="gene ID" value="TDE_0591"/>
    </dbReference>
    <dbReference type="GeneID" id="2741554"/>
    <dbReference type="KEGG" id="tde:TDE_0591"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.571"/>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_12"/>
    <dbReference type="OMA" id="FVEICSH"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="6">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="120"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="439" mass="47443" checksum="8129597EA1ED5721" modified="2004-07-05" version="1">MIKKILIANRGEIAVRVIRSCREMGIKTVAVYSTADKDCLHVLLADEAVCIGPPPSAKSYLNKEALITAALCTSCEAVHPGVGFLSENAGFAREVENAGLFWIGPKPDTIEMLGDKVRARETAVKSGLPVTPGSDGAIKELAEAKKTAEKCGYPVIIKAASGGGGKGMRIVYKESELAENLKIASAEAEANFADGTVYIEKYLVDPRHVELQILGNGKGAVSVLGERDCSVQKNHQKLIEESPSPAVSEEMREAMCKGAVSLFSSLKYRGAGTIEFLVSGNNFYFMEVNARIQVEHPVSEMITGTDIIAEQIRVCTGENMKFAQGILPTKGWAIEARINARSPGLIKNLRVPGGNGVRFDSFLYQGYSVVPFYDSMTAKLIVHGADRANAIQKLLCALDELKIEGITCNIEEQKIILNSKKFKSGVFGTGLYEELFGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q75</accession>
    <name>Q73Q75_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971182.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681738.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0568"/>
    <dbReference type="EnsemblBacteria" id="AAS11063">
        <property type="protein sequence ID" value="AAS11063"/>
        <property type="gene ID" value="TDE_0568"/>
    </dbReference>
    <dbReference type="GeneID" id="2741004"/>
    <dbReference type="KEGG" id="tde:TDE_0568"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.552"/>
    <dbReference type="eggNOG" id="ENOG5031DMP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2344179_0_0_12"/>
    <dbReference type="OrthoDB" id="2009069at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="99" mass="10920" checksum="6004C621F797DAA1" modified="2004-07-05" version="1">MIPIQGLGLLYVMVIYIGGISLISKLSFISSQSSKVQTIVILISHIILSTINYFLSRFLNRNGVKHSVAGARLENSVIALSLILLFVICLMIYGEFFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QA1</accession>
    <name>Q73QA1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971156.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002665857.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0542"/>
    <dbReference type="EnsemblBacteria" id="AAS11037">
        <property type="protein sequence ID" value="AAS11037"/>
        <property type="gene ID" value="TDE_0542"/>
    </dbReference>
    <dbReference type="GeneID" id="2740530"/>
    <dbReference type="KEGG" id="tde:TDE_0542"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111226_4_1_12"/>
    <dbReference type="OMA" id="IEICYNP"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="160" mass="18049" checksum="274653E7D964F3C6" modified="2004-07-05" version="1">MLHLEKVNGKNIWDILKLQVSEAQKSFVAANDISIIEAYITITANGYAFPFGIYDNETPVGFLMIGFDVHDDWIDAPEIAKGNYNLWRLMIDKAYQNNGFGKDAVKLALDFVKTFPCGKAEYCWLSYEPENQVARKLYSSFGFVETGDTDGEELISALKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QB3</accession>
    <name>Q73QB3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imm12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971144.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672522.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0530"/>
    <dbReference type="EnsemblBacteria" id="AAS11025">
        <property type="protein sequence ID" value="AAS11025"/>
        <property type="gene ID" value="TDE_0530"/>
    </dbReference>
    <dbReference type="GeneID" id="2741749"/>
    <dbReference type="KEGG" id="tde:TDE_0530"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.516"/>
    <dbReference type="eggNOG" id="ENOG5033N8S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149396_0_0_12"/>
    <dbReference type="OMA" id="EYTTEFC"/>
    <dbReference type="OrthoDB" id="1728733at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029088">
        <property type="entry name" value="Imm12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15560">
        <property type="entry name" value="Imm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Imm12" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="146" mass="16637" checksum="34E9E12355F26164" modified="2004-07-05" version="1">MEVILSTVIGGEITVEVDGGKIVHSLIIKMRNSLKEHFKKIFFEGLDRIKINVYISGDVSSYCDKTGITATRYFRAKTEYTTEFCIDKNYWSLEPVLPVDRKFILFMENSLIQLGGIIEKKLKAAGYNFDGELFKEIVLKSLRGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QF5</accession>
    <name>Q73QF5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971102.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0488"/>
    <dbReference type="EnsemblBacteria" id="AAS10983">
        <property type="protein sequence ID" value="AAS10983"/>
        <property type="gene ID" value="TDE_0488"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0488"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.473"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092082_1_0_12"/>
    <dbReference type="OMA" id="PTIYDLT"/>
    <dbReference type="OrthoDB" id="1654505at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002901">
        <property type="entry name" value="MGlyc_endo_b_GlcNAc-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01832">
        <property type="entry name" value="Glucosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="LYZ2" evidence="2">
        <location>
            <begin position="73"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="201" mass="22731" checksum="5485B9282704E302" modified="2004-07-05" version="1">MRCIFSETITMRKRIFYIFIFGLSFLFFSCLSFFVRPPHLIESRGRCSADDLTVFFMSQNPKVDRAKVKRLAQFYIEEAETEGINSDIAFSQMCLETGFLRFGGLVSEEMNNFCGLGSLGDGKKGESFPSEKTGVLAHVQHLKAYATAKPLVRPQADPRYKYVNPKGKAPTIYGLAGTWAADPNYGKKLENILTRLYKSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QJ7</accession>
    <name>Q73QJ7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971060.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0446"/>
    <dbReference type="EnsemblBacteria" id="AAS10941">
        <property type="protein sequence ID" value="AAS10941"/>
        <property type="gene ID" value="TDE_0446"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0446"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.433"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038154_0_0_12"/>
    <dbReference type="OMA" id="ENEWRHH"/>
    <dbReference type="OrthoDB" id="983414at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="394"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="499" mass="56348" checksum="960FA20200420CFB" modified="2004-07-05" version="1">MSLIFFNLLLISAFSEDAVLNFGGKLGWNNLFYSRNIEQRNGKFGFQSLGLTSASHNITETTDMYLSFDFKDTIEETGNYTVANSSIIHLGAEKAKIGEGAALFHYNSNNESLTLKPSKTSFFAGTKILKSFTIEFWLCPQTTESGSTILRWWTSLVEGRKTMYQNIAASIFNNKLEWSFLNIWQDKNNKGLDVRLSGKSNIIPEIWSHHLITYDETTGLLEYRMNGKSEAIVYMTETGRESNQVLYSALGTSSDVLIGLNYSGLIDELKVTNFFSQFGMPWEISSLFEKYPQDGGRIETNIIDTGGNKSQPRVLKALYDKPEQTDAEFFIRAADSPFNWNGTYPEWKSIRPNEEIKNISGRFFQIACNIYPDAEGLKSPLIHSFSLEYEKDNLPLPPSKLIARAGDSSVELFWSPSIDTDVKGYLIYFGNKKGEYFVEGSPIDVGNVISYKIENLKNGKIYFFAIAAYDEENGEHAGDTSKEVWARPLQSKKEGKNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QL2</accession>
    <name>Q73QL2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971045.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0431"/>
    <dbReference type="EnsemblBacteria" id="AAS10926">
        <property type="protein sequence ID" value="AAS10926"/>
        <property type="gene ID" value="TDE_0431"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0431"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.418"/>
    <dbReference type="HOGENOM" id="CLU_698170_0_0_12"/>
    <dbReference type="OrthoDB" id="2063919at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="15"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="374" mass="41326" checksum="B7E36932E83A0483" modified="2004-07-05" version="1">MINGGKQTSKDENEGDYTVKQGDTLSKIAREHYPDASTKELSEKIKEIAKNSGIENPDLIRPGQKIVFGDKESSVSSSSSTPSEPSQTQTDSSSTTSQEEYGDKTDYSERGDTEPDMTENTPNKQEKSYGKEKQVNGNGQHSSDEKNSNKQESSFGISIADIKTKKGFFKQDNKLKKIDNDKTIDTSEKFKNQLNNLKTITQDIMDGEHKNKNEYDPDANIFKGQDPKSLTNTIVNFVTNHYEKLPLLGGFGLIAGALYLGNETVRNGINSLIETRGTITKPLNENSNFSFSSLPGTSNTKEGETVYYVQPQFGIDIKTPFKSGAGAGNIYVENRIRTNLDVYSTKTGPFPQLTGKDNNPFSTLQVDIGVQIQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QM0</accession>
    <name>Q73QM0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971037.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002685101.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0423"/>
    <dbReference type="EnsemblBacteria" id="AAS10918">
        <property type="protein sequence ID" value="AAS10918"/>
        <property type="gene ID" value="TDE_0423"/>
    </dbReference>
    <dbReference type="GeneID" id="2739587"/>
    <dbReference type="KEGG" id="tde:TDE_0423"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.410"/>
    <dbReference type="HOGENOM" id="CLU_049884_0_0_12"/>
    <dbReference type="OrthoDB" id="2105747at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010103">
        <property type="entry name" value="Clustered_lipoprot_TREDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09710">
        <property type="entry name" value="Trep_dent_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01781">
        <property type="entry name" value="Trep_dent_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="421" mass="50081" checksum="1D65182C4B1CE5C1" modified="2004-07-05" version="1">MKKDKLKLIFILILAALLFSCSKELKEQKPEETKVESSAKIEPKENEFLSKPEYNTHVKSPEQIKELEEKYKRSEAYEEKLKQLRTELDKKEDILRYKCPVFMSIDNLAQQKAPALYSHADNLDFIHFYEIKKDGEFCYCKYKAPTQNGGILDYQVTYKWYNIEQMYLPLSYDLLSETNMVKINDELIENQVHGSIYSMENDEKKDEMIKLFEDYENTQYPLYLEVANTDWKTGAKTEGYKQYDMKILDYVKGNFTNSGYDEYFVMFYRDHPNPEIDDQFIERVRCFIVSEDKIINDYYISNSGGFFYPGLRYDKLSEVKDFGFKFSQGWIADFNQNGINEIYLAALFDIYGGGLLIIEYNDGSFVSGYVYDNRYDIVGIDWYKKMIIIKDKSRSGEWIDDYQWNDTLKEFILLKRKYRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QM6</accession>
    <name>Q73QM6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971031.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0417"/>
    <dbReference type="EnsemblBacteria" id="AAS10912">
        <property type="protein sequence ID" value="AAS10912"/>
        <property type="gene ID" value="TDE_0417"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0417"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.404"/>
    <dbReference type="HOGENOM" id="CLU_3318657_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="39" mass="4086" checksum="6B8B6D075444A3FB" modified="2004-07-05" version="1">MSSLLDGNFYTPNGSSFIAVSFTGNPATFKLVIGCKADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QP9</accession>
    <name>Q73QP9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide/dipeptide ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0394</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971008.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676750.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0394"/>
    <dbReference type="EnsemblBacteria" id="AAS10889">
        <property type="protein sequence ID" value="AAS10889"/>
        <property type="gene ID" value="TDE_0394"/>
    </dbReference>
    <dbReference type="GeneID" id="2739403"/>
    <dbReference type="KEGG" id="tde:TDE_0394"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.383"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_12"/>
    <dbReference type="OMA" id="MQEDYMR"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS10889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="320" mass="35905" checksum="AD76C25A8D0BA402" modified="2004-07-05" version="1">MKKYILKRSFSAFITIIVVFTINFIIINIAPGNPIKTMMGKETDNIEQTKALEEKYGLNKPLYEQYFRYLKNISTGDLGISIIYNKPVSKMILEKIGPTILLVLTAAVISLLLGTAMGIVAARKEGGFIDVSLSGINYVLNALPSFWLALMLIILFSTKLKWLPTFGMTDPRAGYTGIKYIKDVIIHLILPITTLVLIELPLYFRIAKSSVLQVTNEDFIMTLRAAGMNEKKIFRKYIFKNAILPTITVFGISLAYLITGVALIEIVFAWPGTGRLVLNAINQRDYPVLMGIYLIMSIAIAVMMMVVDIVYAIVDPRIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QQ6</accession>
    <name>Q73QQ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">(R)-hydroxyglutaryl-CoA dehydratase activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hgdC</name>
        <name evidence="4" type="ordered locus">TDE_0387</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971001.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681412.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0387"/>
    <dbReference type="EnsemblBacteria" id="AAS10882">
        <property type="protein sequence ID" value="AAS10882"/>
        <property type="gene ID" value="TDE_0387"/>
    </dbReference>
    <dbReference type="GeneID" id="2740319"/>
    <dbReference type="KEGG" id="tde:TDE_0387"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.376"/>
    <dbReference type="eggNOG" id="COG1924">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066597_0_0_12"/>
    <dbReference type="OMA" id="GKGANYF"/>
    <dbReference type="OrthoDB" id="1837697at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="249" mass="26993" checksum="7E68486AFC511BE8" modified="2004-07-05" version="1">MHYIGIDIGSTATKTVIMDENKKNILYKNRIPSGWNSKETGEAVLDWIKETLQNKDFKITATGYGRVSVPFADKTLTEISCHGKGAHFLAKKDVTVIDIGGQDTKVILVKDGLVIDFIMNDKCSAGTGKFLELMANRLGLSLQEISEYAARGKDLNLSSVCTVFAESEVTSLMGKGSPREDIARGVINQIVSKVVSLANRKPRSDLYFLTGGFSSNDYIIEEISKKLEASVLSDDLGVFAGAIGACILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QZ6</accession>
    <name>Q73QZ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970911.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0297"/>
    <dbReference type="EnsemblBacteria" id="AAS10792">
        <property type="protein sequence ID" value="AAS10792"/>
        <property type="gene ID" value="TDE_0297"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0297"/>
    <dbReference type="HOGENOM" id="CLU_2940465_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="60" mass="7323" checksum="8EF6C4B1911E8AC7" modified="2004-07-05" version="1">MLIFLIQMRYGCIIVLIYSLFLFFPEFHRVHFSCHISHIMLYHFFSIITIFIINGSYYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R41</accession>
    <name>Q73R41_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophanase</fullName>
            <ecNumber evidence="7">4.1.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">L-tryptophan indole-lyase</fullName>
            <shortName evidence="7">TNase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">tnaA</name>
        <name evidence="10" type="ordered locus">TDE_0251</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-tryptophan = indole + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19553"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16881"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="EC" id="4.1.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Amino-acid degradation; L-tryptophan degradation via pyruvate pathway; indole and pyruvate from L-tryptophan: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the beta-eliminating lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.1" evidence="7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970866.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956705.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0251"/>
    <dbReference type="EnsemblBacteria" id="AAS10747">
        <property type="protein sequence ID" value="AAS10747"/>
        <property type="gene ID" value="TDE_0251"/>
    </dbReference>
    <dbReference type="GeneID" id="2739676"/>
    <dbReference type="KEGG" id="tde:TDE_0251"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.246"/>
    <dbReference type="eggNOG" id="COG3033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047223_0_0_12"/>
    <dbReference type="OMA" id="MFPHIPY"/>
    <dbReference type="OrthoDB" id="91973at2"/>
    <dbReference type="UniPathway" id="UPA00332">
        <property type="reaction ID" value="UER00452"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009034">
        <property type="term" value="F:tryptophanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00544">
        <property type="entry name" value="Tryptophanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011166">
        <property type="entry name" value="Beta-eliminating_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013440">
        <property type="entry name" value="TNase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018176">
        <property type="entry name" value="Tryptophanase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001386">
        <property type="entry name" value="Trpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00853">
        <property type="entry name" value="BETA_ELIM_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="9">
        <location>
            <begin position="47"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR611166-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="459" mass="51669" checksum="9C41D32C048D7C72" modified="2004-07-05" version="1">MKKYVPEPFRIKMVEPIKMTTREDRIKYLEKAKYNMFNLRGEDVYIDLLTDSGTNAMSDKQWGGVMVGDEAYAGGKSYFKLVDAGKDIFGYEFIQPVHQGRAAEKVLFPLLLKKGQVAISNMFFDTTRAHVTLAGGRPLDCVCKEAKKPSEYAPFKGNMDVEKLEQLINEHGKEKVGMIVMTITNNSAGGQPVSIQNIRDVAKIAKKYGILFNIDAARFAENAYFVKQREEEFKNKPIKEIIREMFSYADTFTMSAKKDAIVNMGGLIGIKNNQEIYQMIKGNCISFEGFITYGGLSGRDLEALAIGLYEGIDEEYLKYRNASMEYLASQLLDAGVAIQNPAGGHGVYVDANAMFPHIPYYQFPGHTLCVELYKEAGIRTCDIGSFMLGNDPETGEQIKSEFEFARLAIPRRVYTQSHLDVIAGALINIKERASQVKGYKIIWEPPILRHFQAHLEPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R48</accession>
    <name>Q73R48_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970859.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681159.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0243"/>
    <dbReference type="EnsemblBacteria" id="AAS10740">
        <property type="protein sequence ID" value="AAS10740"/>
        <property type="gene ID" value="TDE_0243"/>
    </dbReference>
    <dbReference type="GeneID" id="2741442"/>
    <dbReference type="KEGG" id="tde:TDE_0243"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.238"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_12"/>
    <dbReference type="OMA" id="LAYGMEQ"/>
    <dbReference type="OrthoDB" id="870493at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="261"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="296"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="491" mass="55156" checksum="B558D989C49ABA1F" modified="2004-07-05" version="1">MLSLKDISYKTRTGLLILDNINLEIKKGEFVVITGKSGSGKSTLGSVINGLISHYYDGVLTGEAYLNGKDIRTMELSQIGCMVGCVFQDPRSQFFMTDPFSETAFGCSNMLLNREEILKRVDNSLKLLGINHLKEKSIFKLSSGEKQKLAIASCYAMSPDIFLFDEPTANLDIHSIFDLENILRSLKEEGKTIIVLEHRLFYLSALCSRMLVMDKGRITGEYSKDEFLELQKNNKNIRPIYLENLDTVHSKSIIDKTTPLFEIKNISYSHSKQEKTDVLKDISIRAYEKEVIGIIGENGAGKTTLAKLCTGLLKEKSGSVLIKGEKRSYKKRAGSMYFVMQDSDYQLFGNTVADELDIGKKGGGLSGTEKETVLSDFEILDLKEWHPLALSRGQKQRLTIAAAFCNNCKILFLDEPTSGLDKHSMDLVSKSVLTEANAGRLIFVISHDYEFLLSVCNRIIYLKSGMVHADFNLNNDTKKMLWELLSKKEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R61</accession>
    <name>Q73R61_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">recF</name>
        <name evidence="9" type="ordered locus">TDE_0230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970846.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681135.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0230"/>
    <dbReference type="EnsemblBacteria" id="AAS10727">
        <property type="protein sequence ID" value="AAS10727"/>
        <property type="gene ID" value="TDE_0230"/>
    </dbReference>
    <dbReference type="GeneID" id="2739082"/>
    <dbReference type="KEGG" id="tde:TDE_0230"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.223"/>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040267_0_1_12"/>
    <dbReference type="OMA" id="GESWSYA"/>
    <dbReference type="OrthoDB" id="891841at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="360" mass="41553" checksum="342AF306BE4A0BAF" modified="2004-07-05" version="1">MPFLSASFYNFRNLENATVDISSPEVFLVGKNGQGKTNFLEALYVSSYGTSFRTRSLAQICTKDEKEFSIRALYKESDNISHTISIIIQDKKKDIQKNFKKIKNSKELISTIPCILFHGDDIEFAVGTPSRKRFFIDQSVSLCNSDFIEVLVKYSKALKSRNVILEQKKASLLDSIDEIFASLALLITNERKNIVEEYAKHFSLIYEEISGVSGVEMVYRPSVKVESEEDLLILLAEKRQNDLIDRTSSTGPHRDRIHFIKDKKPFTERASNGQRRLISLVLRMIQAKIYSEKTGRKPIFLMDDILLELDPEKRQKFMELLPPYEQLFCTFLPGEPYKNYQKENTKIFFVEDGKFSVERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R68</accession>
    <name>Q73R68_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970839.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681126.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0223"/>
    <dbReference type="EnsemblBacteria" id="AAS10720">
        <property type="protein sequence ID" value="AAS10720"/>
        <property type="gene ID" value="TDE_0223"/>
    </dbReference>
    <dbReference type="GeneID" id="2740777"/>
    <dbReference type="KEGG" id="tde:TDE_0223"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.216"/>
    <dbReference type="HOGENOM" id="CLU_1260987_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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        <location>
            <begin position="24"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS10720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="219" mass="25052" checksum="6CC458B3C6C039A0" modified="2004-07-05" version="1">MAIRKVIFLTLLIMMLSSCTTSGYDSFRTRESSFNQTQIVTSNSAFSKEMITTILETKFPPNKIVSIAILFIDKQSPYSADFSIEIMKKSNLINGVEKFVSVPSIMIPNKLTFDDIQQIGIRSLCEYTLVFYSESRTEMSFTQFIKGEIEFKSDVEFSLIDNQTTAVIASDRLVTKIMKKNKFFNDKIIEQAKNEVFNEQANILVVKLNALFSSKYQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
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            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
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    </feature>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
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                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
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                <person name="Kolonay J."/>
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                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
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                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
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                <person name="Sodergren E."/>
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                <person name="Weinstock G.M."/>
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            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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        </location>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS10640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0142"/>
    <dbReference type="EnsemblBacteria" id="AAS10640">
        <property type="protein sequence ID" value="AAS10640"/>
        <property type="gene ID" value="TDE_0142"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0142"/>
    <dbReference type="HOGENOM" id="CLU_3399002_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="31" mass="3288" checksum="7D880CDB61A35C5C" modified="2004-07-05" version="1">MIFHMLPPPVLSGSGNRASVRTALCGYVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RG0</accession>
    <name>Q73RG0_TREDE</name>
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        <submittedName>
            <fullName evidence="9">HAMP domain/GGDEF domain/EAL domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_0128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
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            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="RefSeq" id="WP_002680994.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="EnsemblBacteria" id="AAS10626">
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        <property type="gene ID" value="TDE_0128"/>
    </dbReference>
    <dbReference type="GeneID" id="2739584"/>
    <dbReference type="KEGG" id="tde:TDE_0128"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.128"/>
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    <dbReference type="OrthoDB" id="1635706at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dCache_1"/>
    </dbReference>
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        <property type="entry name" value="GGDEF_dom"/>
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        <property type="entry name" value="Nucleotide_cyclase"/>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
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            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10626.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="801" mass="91939" checksum="B7CD0F16DAEBD696" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RJ0</accession>
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            <fullName evidence="4">Conserved domain protein</fullName>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AAS10596">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.98"/>
    <dbReference type="eggNOG" id="COG0726">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229452_0_0_12"/>
    <dbReference type="OMA" id="CGHTIIS"/>
    <dbReference type="OrthoDB" id="1624082at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025303">
        <property type="entry name" value="PdaC"/>
    </dbReference>
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        <property type="entry name" value="PdaC/RsiV-like_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13739">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284665" evidence="1">
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            <begin position="21"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PdaC" evidence="3">
        <location>
            <begin position="50"/>
            <end position="135"/>
        </location>
    </feature>
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        <location>
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            <end position="235"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10596.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="239" mass="26602" checksum="62F9A650AAD4E1FB" modified="2004-07-05" version="1">MKSKIMVLFCFVLFVFSLNASGAAETSSHDAIGGATESNSKAEVKQAAVHCELKIDFPTFEDVPALNAIVSKTVKGKVTAFWNNYYSVSPDDMAKSSTPQNFELIIGYDDIVRDGNYISFVLSVYEYMGGAHGLTSLVPINYDIKTKKLVSLSDVVRPASKNWLVKLSNEARKILMEKVKKGDLSSDESMIKEGTEPKLENFKVFKIENGKIKIIFEQYQVAPYSEGLPEIIIPIDFFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RJ6</accession>
    <name>SYC_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.16</ecNumber>
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        <alternativeName>
            <fullName evidence="1">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="1">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysS</name>
        <name type="ordered locus">TDE_0092</name>
    </gene>
    <organism>
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        <lineage>
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    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970709.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666765.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73RJ6"/>
    <dbReference type="SMR" id="Q73RJ6"/>
    <dbReference type="STRING" id="243275.TDE_0092"/>
    <dbReference type="EnsemblBacteria" id="AAS10590">
        <property type="protein sequence ID" value="AAS10590"/>
        <property type="gene ID" value="TDE_0092"/>
    </dbReference>
    <dbReference type="GeneID" id="2741707"/>
    <dbReference type="KEGG" id="tde:TDE_0092"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.93"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_12"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000159510" description="Cysteine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="279"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <sequence length="492" mass="55951" checksum="251EF31954334EC4" modified="2004-07-05" version="1">MSLKLHNTLGNKKEEFIPIHEGKAGVYGCGPTVYDYAHIGNLRTYVFQDILVKTLRFLGYDVTHVMNITDVGHLTDDEDSGEDKMVKSAEERGKSVLEIAEFYTKAFFNDTERLNIERPGIVCKATEHINEMIELIKRIEANGHTYMAGGNLYYDISTFPKYGELANINLEDLKAGARIEIDKNKRNPHDFVLWFTKSKFENQALVWDSPWGRGYPGWHIECSAMSMKYLGEQIDIHKGGIDHIRVHHTNEIAQSEGATGKKWVNYWLHNEFLVMNKGKMSKSAGSFIILEDVINKGFSALDYRFLLLGGHYRSQLTFSWEAMETAKNGRKNLNNRVAKWLDGLSDSEIMEYAALTENLNLKSAKDMIKNEKARSCFDNFIAAMEDDLSTPKALSELQLLIKEKDIPQKDVLTVLAAMDSILGIKLIEESFNTLKDKGSIEIDESEILKLIEERASAKLDKNYKLADEIRDKLKGMGIILEDQAGKTTWKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RM0</accession>
    <name>Q73RM0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, M20/M25/M40 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970685.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680921.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0068"/>
    <dbReference type="EnsemblBacteria" id="AAS10566">
        <property type="protein sequence ID" value="AAS10566"/>
        <property type="gene ID" value="TDE_0068"/>
    </dbReference>
    <dbReference type="GeneID" id="2741683"/>
    <dbReference type="KEGG" id="tde:TDE_0068"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.69"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_2_2_12"/>
    <dbReference type="OMA" id="STFEPTM"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010182">
        <property type="entry name" value="ArgE/DapE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01910">
        <property type="entry name" value="DapE-ArgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="202"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="411" mass="45319" checksum="C77877FB0E22D66B" modified="2004-07-05" version="1">MSTFKKITDFIESKTNDIIGLERLLTSIPAMAPESDGDGELKKCEALEKYLKEAGFSNFERLDAPDERVSSKIRPNLIVTIPGKNDKERLWIMSHLDVVPPGDLSKWESDPWTVIEKDGKLIGRGVEDNQQGLVSSVFAALAFIKLGITPEHTIKLLFVADEEVGSQYGIIYLLNKHNLFTNDDLILVPDGGDPKGETIEIAEKTGLWLKVITKGVQTHASMPNTGKNAFVAACDLALRLNDLENHFNKKDDLFSPNYSTFQPTKKEANVPNVNTIPGDDVFYVDCRILPSYDVNEVLKEMQKRASEVEKKYGVGIRFEYDEPEASPATPKDAKIVSLLSSAVKKVKGIETSTIGIGGGTVAACLRSKGFNAVVWSSLDDSCHQPNEYAFIKNIISDAKVMAAMMFGVENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RR0</accession>
    <name>Q73RR0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970642.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680884.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0025"/>
    <dbReference type="EnsemblBacteria" id="AAS10523">
        <property type="protein sequence ID" value="AAS10523"/>
        <property type="gene ID" value="TDE_0025"/>
    </dbReference>
    <dbReference type="GeneID" id="2741640"/>
    <dbReference type="KEGG" id="tde:TDE_0025"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.27"/>
    <dbReference type="eggNOG" id="ENOG50343GE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1748856_0_0_12"/>
    <dbReference type="OMA" id="VYEIYWM"/>
    <dbReference type="OrthoDB" id="1350653at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="152" mass="18213" checksum="9C5CCD7A2E5355DA" modified="2004-07-05" version="1">MFDMKPVIIKKIFKNQPHYILTWSPLKKADKYQINRAVPAMSGVYELYKMDKEKHLNLLSVTHAWYGGLRSNIREAIDPDTKTDPERRKILEDDDIELYYRYSCSDSFGDLLDVVWFLHSTYFPDDIRVESSNRYENFFLTERAPDKVYWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RR3</accession>
    <name>Q73RR3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970639.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666906.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73RR3"/>
    <dbReference type="STRING" id="243275.TDE_0022"/>
    <dbReference type="EnsemblBacteria" id="AAS10520">
        <property type="protein sequence ID" value="AAS10520"/>
        <property type="gene ID" value="TDE_0022"/>
    </dbReference>
    <dbReference type="GeneID" id="2741637"/>
    <dbReference type="KEGG" id="tde:TDE_0022"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.24"/>
    <dbReference type="eggNOG" id="ENOG5031CGS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121469_0_0_12"/>
    <dbReference type="OMA" id="EYALRID"/>
    <dbReference type="OrthoDB" id="1782798at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="189" mass="21787" checksum="6E3EE415F7BA47F1" modified="2004-07-05" version="1">MVDPIFSDEFLMSPEIKDIAVLEIPKFIDAADNEIAASALKISKAFGRGASFEIYTDKTNVDAEKNLIESFRKNIQLLVQKTWVEKDDEECKEDTLYRINCLCEKLISSEHSAAYKESFEDCFAILHDVVTLLFGDLVKTDSFVEYAFRIDPDFGFFWYYVTRLSKVEIISEEKARYASLLAMFFLANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RR7</accession>
    <name>Q73RR7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970635.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680874.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0018"/>
    <dbReference type="EnsemblBacteria" id="AAS10516">
        <property type="protein sequence ID" value="AAS10516"/>
        <property type="gene ID" value="TDE_0018"/>
    </dbReference>
    <dbReference type="GeneID" id="2741633"/>
    <dbReference type="KEGG" id="tde:TDE_0018"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.20"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108963_0_0_12"/>
    <dbReference type="OMA" id="KHSASKM"/>
    <dbReference type="OrthoDB" id="1862973at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285939" evidence="2">
        <location>
            <begin position="23"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="68"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="166" mass="18747" checksum="EDB5153D74870724" modified="2004-07-05" version="1">MKNILKILAIMALFSFVLTSCGTPPTPPPEEKPAPVVVEEPTPAPEPVKEAAPEPKPVVEEPRDVPVKEYVVVEGDTLSEIALKFYGTREKAYYFPIIMTLNPGRIQHPDKLTPKTKLLIPDFELFMKHSASKMLARPEFEKCIKIYEDEGKSGVVESLRRRLKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RS5</accession>
    <name>Q73RS5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MutT/nudix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970627.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680868.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0010"/>
    <dbReference type="EnsemblBacteria" id="AAS10508">
        <property type="protein sequence ID" value="AAS10508"/>
        <property type="gene ID" value="TDE_0010"/>
    </dbReference>
    <dbReference type="GeneID" id="2741625"/>
    <dbReference type="KEGG" id="tde:TDE_0010"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.12"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_8_2_12"/>
    <dbReference type="OMA" id="IFVRQYR"/>
    <dbReference type="OrthoDB" id="1831818at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="42"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="188" mass="21297" checksum="1CE8BEAB3C4E5047" modified="2004-07-05" version="1">MEKNNEIVWKPTVSREILKTRVFSVCEKDSISPEGEKKTFISLKAPSWVIVIPVYQNSSGEDIFVMVQQWRHGSESVCIEFPGGVVDKGEKPEDAALRELLEETGRTPKNIKCLSTLSPNPAIMENSCTVFLAELDKGEVKQNLDEDEFLNILEIPVKKVIQNMGNPPYTHAIMNAALFLYLKEKQYH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-05" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>P62477</accession>
    <name>RSMH_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmH</name>
        <name type="synonym">mraW</name>
        <name type="ordered locus">TDE_1198</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971805.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678681.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P62477"/>
    <dbReference type="SMR" id="P62477"/>
    <dbReference type="STRING" id="243275.TDE_1198"/>
    <dbReference type="EnsemblBacteria" id="AAS11716">
        <property type="protein sequence ID" value="AAS11716"/>
        <property type="gene ID" value="TDE_1198"/>
    </dbReference>
    <dbReference type="GeneID" id="2741159"/>
    <dbReference type="KEGG" id="tde:TDE_1198"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1153"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_2_0_12"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="OrthoDB" id="1272633at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000108736" description="Ribosomal RNA small subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <sequence length="315" mass="35696" checksum="53B87832D34D2939" modified="2004-07-05" version="1">MQPVHTSVLLEECLEFLKPDASDNLFVDGTLGEGGHTEAFLKRYPQLNAIGVDADVSIQERAKERLKPFGERIRFHLGWSDEFFKNYPKDFAPPNLILLDLGISMFHYVKSGRGFSFSSDEPLDMRLNPELRLSAADIVNSYNEKDLADLIFNYGEERYSRKIASRIVEQRAAAAFSNAKELADCIYKAVPQNYRHGKIHPATKTFQALRIAVNGELDRLPRLLEAAFSVLAPNGRLGLITFHSLEDRIVKFYFKELGKSCTCPENMPICKCGGRPRAEVLTKKAVKASDEEIRLNPPSRSARLRVVRKIDYRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73IZ4</accession>
    <name>Q73IZ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TDE_2783</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973381.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680844.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2783"/>
    <dbReference type="EnsemblBacteria" id="AAS13300">
        <property type="protein sequence ID" value="AAS13300"/>
        <property type="gene ID" value="TDE_2783"/>
    </dbReference>
    <dbReference type="GeneID" id="2739172"/>
    <dbReference type="KEGG" id="tde:TDE_2783"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2626"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_12"/>
    <dbReference type="OMA" id="GIYMTHE"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="318"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="10">
        <location>
            <begin position="419"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS13300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="705" mass="76834" checksum="52437FD35F82195F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J30</accession>
    <name>Q73J30_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hsdM-2</name>
        <name evidence="6" type="ordered locus">TDE_2746</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
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            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="TDE_2746"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.2592"/>
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        <property type="entry name" value="DNA_methylase_A-5"/>
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        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
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    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="HsdM_N" evidence="5">
        <location>
            <begin position="15"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="4">
        <location>
            <begin position="130"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS13263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="480" mass="53237" checksum="385A4D6EB882D5D3" modified="2004-07-05" version="1">MAKKEATQAKPEQALTKKVWNMADVLAAAGIGFTDYIIQLTYLLFLKMDFEKESYGLGSALPDGSKWKDIVQLDGPDQLAKYEKILEVLQAADGLIGAIFTEAQNKIAKPALLKKLIGMIDEENWFSMDGDLKGAIYESILEKNGQDKKSGAGQYFTPRPLINAMVDVVQPKITETVADPACGTGGFLLSAYDYMRKQSDEQSKVEFLQTKALRGNDITPLVVTLASMNLYLHDIGVDTTPIKCEDSLEHEPEHLVDVILANPPFGARPAGSVDISTMRSDLIVTTSNNQLNFLQHMMVMLKDGGRAGIVLPDNVLFADGAGEILRKKLLKDFNLHTILRLPTGIFYANGVKANVLFFEKGSPTQETWYYDYRTGIKHTLATKPLKRSDLEDFVSCYCAGHVEDRKETWSPENPNGRWRKYHVDELLARDKTGLDISWIKDGSDTVDCSLAELMQTIQTKSANIAAAVTELSKLIEGIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J76</accession>
    <name>Q73J76_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Citrate carrier protein, CCS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sodium:citrate (SCF) symporter family.</text>
    </comment>
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        <property type="protein sequence ID" value="AAS13217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680734.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2700"/>
    <dbReference type="EnsemblBacteria" id="AAS13217">
        <property type="protein sequence ID" value="AAS13217"/>
        <property type="gene ID" value="TDE_2700"/>
    </dbReference>
    <dbReference type="GeneID" id="2739287"/>
    <dbReference type="KEGG" id="tde:TDE_2700"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2550"/>
    <dbReference type="eggNOG" id="COG3493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041211_0_1_12"/>
    <dbReference type="OMA" id="NMGGTGD"/>
    <dbReference type="OrthoDB" id="1093189at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008514">
        <property type="term" value="F:organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="2-OHcarboxylate_transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40033">
        <property type="entry name" value="PTHR40033"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="2HCT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YxkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="1" id="KW-0769">Symport</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
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            <end position="31"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="269"/>
        </location>
    </feature>
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            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="334"/>
        </location>
    </feature>
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        <location>
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            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="430" mass="45161" checksum="1BCDA7F149FD7FDF" modified="2004-07-05" version="1">MVNEKKKYEILGMPLTLFGIISAVVIAAIWWNKLPGGMIGALLLMMVLGEVLNIIGDNTPIVKTFFGGGPIVIIFASSALAYYNILPEGILKNTSTFMKSGGFLDFYIAALITGSILGMDRKLLIKAAIRYFPCIIGSVAAALVLVALGAPIFGMKATEAIAYIGIPIMGGGMGAGAVPISQVFSSALKIPTEQILSKLVPAVALGNALAIVAGGVLNKLGKIKPSWTGNGQLLASGTFEVPNDEELQRHFSLLEFGIAIVIATAFFTWGNIVSNLFKLIGVNIHTYAWMIISVAVVKAANILPKNFENACALWYKFVAKNFTAALLVGIGIAYTNLGDIIGAFSISYVVLVLLVVIGAGLIGKLVGFYPIEAAITAGLCMANMGGTGDVAVLTASKRMELMPFAQISSRLGGAFIILLASFLVPLFFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J77</accession>
    <name>Q73J77_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antigen, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973297.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680732.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2699"/>
    <dbReference type="EnsemblBacteria" id="AAS13216">
        <property type="protein sequence ID" value="AAS13216"/>
        <property type="gene ID" value="TDE_2699"/>
    </dbReference>
    <dbReference type="GeneID" id="2739286"/>
    <dbReference type="KEGG" id="tde:TDE_2699"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2549"/>
    <dbReference type="eggNOG" id="COG4372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_483897_0_0_12"/>
    <dbReference type="OMA" id="YRIIHAV"/>
    <dbReference type="OrthoDB" id="1143400at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007926">
        <property type="entry name" value="Borrelia_P83"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05262">
        <property type="entry name" value="Borrelia_P83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="555" mass="61777" checksum="38E2C7262EEE4869" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J93</accession>
    <name>Q73J93_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Jag_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973280.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667114.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2682"/>
    <dbReference type="EnsemblBacteria" id="AAS13199">
        <property type="protein sequence ID" value="AAS13199"/>
        <property type="gene ID" value="TDE_2682"/>
    </dbReference>
    <dbReference type="GeneID" id="2739269"/>
    <dbReference type="KEGG" id="tde:TDE_2682"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2534"/>
    <dbReference type="eggNOG" id="COG1315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026157_1_0_12"/>
    <dbReference type="OMA" id="TGHVKFK"/>
    <dbReference type="OrthoDB" id="379544at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005646">
        <property type="entry name" value="FapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038247">
        <property type="entry name" value="Jag_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032782">
        <property type="entry name" value="KhpB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38032">
        <property type="entry name" value="PTHR38032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03961">
        <property type="entry name" value="FapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jag_N" evidence="1">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="656" mass="72536" checksum="9D29A006A12A3840" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JE2</accession>
    <name>Q73JE2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973231.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680654.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2633"/>
    <dbReference type="EnsemblBacteria" id="AAS13150">
        <property type="protein sequence ID" value="AAS13150"/>
        <property type="gene ID" value="TDE_2633"/>
    </dbReference>
    <dbReference type="GeneID" id="2740807"/>
    <dbReference type="KEGG" id="tde:TDE_2633"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2489"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_5_2_12"/>
    <dbReference type="OMA" id="MNINQKS"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="87" mass="10449" checksum="C15CD26F7489AB3D" modified="2004-07-05" version="1">MNINQKSKFKHLTAFILVILAEDPRNRRDIDTEQLQDFPGFTIGMFTVYCCLRSLKREGSVTIWKEDIEIRKHNFKVFLQKFNERKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JH7</accession>
    <name>Q73JH7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973196.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680583.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2598"/>
    <dbReference type="EnsemblBacteria" id="AAS13115">
        <property type="protein sequence ID" value="AAS13115"/>
        <property type="gene ID" value="TDE_2598"/>
    </dbReference>
    <dbReference type="GeneID" id="2741302"/>
    <dbReference type="KEGG" id="tde:TDE_2598"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2456"/>
    <dbReference type="eggNOG" id="ENOG5033D2Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102574_0_0_12"/>
    <dbReference type="OMA" id="YKRNIFF"/>
    <dbReference type="OrthoDB" id="1391139at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="203" mass="25248" checksum="AFA6F3FE2D8D67F0" modified="2004-07-05" version="1">MKRRFFFFVILCFFIFSGQVFPYFVEYKEQYYKLYHIHYEQDPDDIVENIYWLERAINADFCNPLHALGKITTKKEWEKYRYMFMMHLNLKMVEQHLRLGSKYDKQAAYFYNYPWKEQNIESLSKAEEFYETALVYWHEAKLWAEKANMREFQFLFLDSLPFWENERARIASGDLNYERTIKRELLRLQKVREDFMNMDDSTY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JJ4</accession>
    <name>RL1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplA</name>
        <name type="ordered locus">TDE_2424</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973023.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667601.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JJ4"/>
    <dbReference type="SMR" id="Q73JJ4"/>
    <dbReference type="STRING" id="243275.TDE_2424"/>
    <dbReference type="EnsemblBacteria" id="AAS12942">
        <property type="protein sequence ID" value="AAS12942"/>
        <property type="gene ID" value="TDE_2424"/>
    </dbReference>
    <dbReference type="GeneID" id="2739849"/>
    <dbReference type="KEGG" id="tde:TDE_2424"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2291"/>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_12"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="OrthoDB" id="1671455at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000125767" description="50S ribosomal protein L1">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <sequence length="226" mass="24680" checksum="64EA0D054DD01F23" modified="2004-07-05" version="1">MKHGKNYKNALAKYDSAASYELPKAVDIVKELKYAKFDETVEVHVSLTLGKGQSVRDTLVLPHQFRGEKKVLVFCTDDRVKEALDAGAAYAGSTEYIEKVKGGWLDFDIAVATPDMMKDVGRLGMVLGRRGLMPNPKTGTVTTDIASAINELKKGRVEFRADKGGVVHLPVGKVSMDSSKIVENVQALINETMRKKPADAKGDYIRSVSISSTMGPGVWVDYKVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JK9</accession>
    <name>Q73JK9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973008.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680344.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2409"/>
    <dbReference type="EnsemblBacteria" id="AAS12927">
        <property type="protein sequence ID" value="AAS12927"/>
        <property type="gene ID" value="TDE_2409"/>
    </dbReference>
    <dbReference type="GeneID" id="2740711"/>
    <dbReference type="KEGG" id="tde:TDE_2409"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2275"/>
    <dbReference type="eggNOG" id="COG3247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091585_8_0_12"/>
    <dbReference type="OMA" id="GITHIVY"/>
    <dbReference type="OrthoDB" id="1908504at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005325">
        <property type="entry name" value="DUF308_memb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03729">
        <property type="entry name" value="DUF308"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="173" mass="18854" checksum="64D4991569C72D83" modified="2004-07-05" version="1">MSEKKLSYSMIFLAIAVMSTVLGLVCIFNPDSITRIIVTIVGISLIVYGLVEIYQFLSIKMNTFLVLGIILIGLGLLCLVNPSAVLGLIGLVLGLFLICLGAVEVKKSFDLKRYGVKLWWLWLIFAGIVCLIGLSGLFNPASISGLFASLIGFGFLINGISSIWLFFVLKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JN3</accession>
    <name>Q73JN3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973035.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680375.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2436"/>
    <dbReference type="EnsemblBacteria" id="AAS12954">
        <property type="protein sequence ID" value="AAS12954"/>
        <property type="gene ID" value="TDE_2436"/>
    </dbReference>
    <dbReference type="GeneID" id="2739861"/>
    <dbReference type="KEGG" id="tde:TDE_2436"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2304"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071023_2_0_12"/>
    <dbReference type="OMA" id="CLEAKNI"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="254" mass="29708" checksum="2EECCC9E714A8D13" modified="2004-07-05" version="1">MIKKFEDLTLQDDFMFCKVMQNEGLCKMLIEMILSDTIGKITYISVQHNLKNYEQAKSVRFDVLVQTENGKFYDVEMQVSNEKNIPKRMRFYQAAIDISFLDKGNSYNNLNDSFIIFICTFDAIGKNRPIYTFENICLEAKNISLQDGTKKIIINAEAFKDTEDKELKEFLKYLKTGKAKSEFTRRIEEMIQTVKQNEQARQEYRLMSTFEMDAMDRGAYKTKKETAKLMKQKNFDIALIKEITGLPETEIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JP7</accession>
    <name>Q73JP7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973060.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2462"/>
    <dbReference type="EnsemblBacteria" id="AAS12979">
        <property type="protein sequence ID" value="AAS12979"/>
        <property type="gene ID" value="TDE_2462"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2462"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2329"/>
    <dbReference type="HOGENOM" id="CLU_3318654_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="39" mass="4535" checksum="C5D11BA99FDDB936" modified="2004-07-05" version="1">MAIFKNLVGFLKMADEFKIKSLYFDDLILNIANKVKETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JS3</accession>
    <name>Q73JS3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973085.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680453.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2487"/>
    <dbReference type="EnsemblBacteria" id="AAS13004">
        <property type="protein sequence ID" value="AAS13004"/>
        <property type="gene ID" value="TDE_2487"/>
    </dbReference>
    <dbReference type="GeneID" id="2741460"/>
    <dbReference type="KEGG" id="tde:TDE_2487"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2353"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_18_6_12"/>
    <dbReference type="OMA" id="QTWREAY"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="168" mass="19575" checksum="BB9D2EC5539C33E1" modified="2004-07-05" version="1">MVRLAELKDLSRVAEINVYGWRNTYRGIVDDNFLFCELSVEKSIERLKEKVNTQNSTSKLYVYEDDKDGIIKGMMRTGMCRDSDKPDSFELMAIYVEKAFERSGVGSKLITYFQKEAKEAGIHELCIWVFQENRIARSFYEHHGFKPDGKTQVHEALKAPEMRYVKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JT0</accession>
    <name>Q73JT0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973077.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680447.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2479"/>
    <dbReference type="EnsemblBacteria" id="AAS12996">
        <property type="protein sequence ID" value="AAS12996"/>
        <property type="gene ID" value="TDE_2479"/>
    </dbReference>
    <dbReference type="GeneID" id="2741452"/>
    <dbReference type="KEGG" id="tde:TDE_2479"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2345"/>
    <dbReference type="eggNOG" id="ENOG5031PAP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1905844_0_0_12"/>
    <dbReference type="OrthoDB" id="2036105at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="2">
        <location>
            <begin position="15"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="129" mass="14292" checksum="00E83BCECCEADF5C" modified="2004-07-05" version="1">MYLDKAAAMELVDGDMEIYMSLLETFIEAYEKDEAEIDRLNVLLGASAEAILSDDVLRENVRKTAHKIKGSSYTVGANILGDSAKNIEKFLVEPSNIKSPANIELLDGFLAKFKENYGNTLKEMKTVIA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JT1</accession>
    <name>UVRC_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein C</fullName>
            <shortName evidence="1">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrC</name>
        <name type="ordered locus">TDE_2478</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973076.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680446.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JT1"/>
    <dbReference type="SMR" id="Q73JT1"/>
    <dbReference type="STRING" id="243275.TDE_2478"/>
    <dbReference type="EnsemblBacteria" id="AAS12995">
        <property type="protein sequence ID" value="AAS12995"/>
        <property type="gene ID" value="TDE_2478"/>
    </dbReference>
    <dbReference type="GeneID" id="2741451"/>
    <dbReference type="KEGG" id="tde:TDE_2478"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2344"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_12"/>
    <dbReference type="OMA" id="HIECFDN"/>
    <dbReference type="OrthoDB" id="1036075at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000227488" description="UvrABC system protein C">
        <location>
            <begin position="1"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <sequence length="652" mass="73707" checksum="5C4443561EEA42A5" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JT4</accession>
    <name>Q73JT4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2501"/>
    <dbReference type="EnsemblBacteria" id="AAS13018">
        <property type="protein sequence ID" value="AAS13018"/>
        <property type="gene ID" value="TDE_2501"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2501"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2368"/>
    <dbReference type="eggNOG" id="COG0745">
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    <dbReference type="HOGENOM" id="CLU_681423_0_0_12"/>
    <dbReference type="OMA" id="TPCILET"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="206"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="324" mass="36050" checksum="C17DF0D3C7E9FFD5" modified="2004-07-05" version="1">MGRKIAKVDIALLASYGVKKVISKPVKVDELLFSIGIILGTTFPMDPTPCILETRVNEDVIFIELAQGLNRDKLELLQFRIIELIESYKLAEAKILIILTDLNLTYADTANLEYLIDNILAVKVVSPKNVKLLTLNQFVTDFFSQNPDYKMIEVVGSLGQALSALLQTTEDKIAVTQTMLNPDNEQNENASNLETRFKLDTAEKLSIAVIDDDLVVRKMMTAIFSGLNAEVTLFENGEDFLNKVENDVYDVVFLDMIMPGMSGIDVLNGAKKKGITTPFVILSSVTQRDSVIKALEKGAKRYILKPIKKETVLRKMEEVLGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JT8</accession>
    <name>Q73JT8_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973095.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2497"/>
    <dbReference type="EnsemblBacteria" id="AAS13014">
        <property type="protein sequence ID" value="AAS13014"/>
        <property type="gene ID" value="TDE_2497"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2497"/>
    <dbReference type="HOGENOM" id="CLU_3384327_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="33" mass="4011" checksum="C56FA42D6991E966" modified="2004-07-05" version="1">MKKLFSQIDICCKKFLWEILWLTNRTLSIILVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JZ1</accession>
    <name>Q73JZ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
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            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973146.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13065">
        <property type="protein sequence ID" value="AAS13065"/>
        <property type="gene ID" value="TDE_2548"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2548"/>
    <dbReference type="HOGENOM" id="CLU_3223408_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="44" mass="5100" checksum="85FC4B3130AE91C4" modified="2004-07-05" version="1">MEPPASVPVNEIQTCYCLKPPASCRELFLRIVFLFALLNTLFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JZ4</accession>
    <name>Q73JZ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS13062">
        <property type="protein sequence ID" value="AAS13062"/>
        <property type="gene ID" value="TDE_2545"/>
    </dbReference>
    <dbReference type="GeneID" id="2739910"/>
    <dbReference type="KEGG" id="tde:TDE_2545"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2406"/>
    <dbReference type="eggNOG" id="ENOG5031CJJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1299268_0_0_12"/>
    <dbReference type="OMA" id="TTEIEWN"/>
    <dbReference type="OrthoDB" id="1421451at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="214" mass="23592" checksum="0AA871746B38921F" modified="2004-07-05" version="1">MDSGIFITDNRLKFSQDLANKLRDKGLKVCLSSEYKEDNKESGVTTEIEWNRSSLFSLQAIPLKLKNINIAADTSILIFDAPAYSKIYPGTDALSIDKTISDLVSANAALSLVLKNYYIKKGQGRLIFVHRDADIPCGNPNISAASAAFARIAEETVDTVRKTELPGVQTLLVKLEGFEDEVFADWLCNQIASPVLSRSPGRWVKAGQRSFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K59</accession>
    <name>Q73K59_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High-affinity branched chain amino acid ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972962.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680283.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2363"/>
    <dbReference type="EnsemblBacteria" id="AAS12881">
        <property type="protein sequence ID" value="AAS12881"/>
        <property type="gene ID" value="TDE_2363"/>
    </dbReference>
    <dbReference type="GeneID" id="2739972"/>
    <dbReference type="KEGG" id="tde:TDE_2363"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2231"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="IMMQKIM"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="235" mass="25808" checksum="D28E4B551DC66699" modified="2004-07-05" version="1">MLLEVKDLHVSYGEIKAIRGINFNINQGEIVTIIGSNGAGKSTTLNSLAGLIKPASGTVLFNGEDVTKLESYELVKKGISLSPEGRQIFPRMSVIENLELGGYFRTRAELEKGKNNVFELFPILKERSWQAGGTLSGGEQQMLAIGRALMASPKILILDEPSLGLAPIIVKEIFKMIRRIRDEGITVLLVEQNAKMALSISDRGYVLETGKIRLEGKSKELLNNEEVHKLYLGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KA5</accession>
    <name>Q73KA5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972914.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2314"/>
    <dbReference type="EnsemblBacteria" id="AAS12833">
        <property type="protein sequence ID" value="AAS12833"/>
        <property type="gene ID" value="TDE_2314"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2314"/>
    <dbReference type="HOGENOM" id="CLU_2572855_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="81" mass="9557" checksum="1C15BD962179A3B4" modified="2004-07-05" version="1">MSLWYSIALFAVNYNFLGFFLFNRSERKALSLRSTSQRCFDSILNNTFLNLPLAFLAGLAVLFYIFKNYSTFTWKRLHNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KA7</accession>
    <name>Q73KA7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972912.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2312"/>
    <dbReference type="EnsemblBacteria" id="AAS12831">
        <property type="protein sequence ID" value="AAS12831"/>
        <property type="gene ID" value="TDE_2312"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2312"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2182"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071023_5_0_12"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="172" mass="19572" checksum="5C2103ED5010E5CE" modified="2004-07-05" version="1">MRRQPLNFAQNFCFLTQPTDCQKLCNNAGFQRTAKPLAARGKEMGSKGKGKTTALNGGLSFPLSKIIINADAFNNTKNKALKGFLEYLKTGKTKNEFTRRIEEMIQTVKQNEQARQEYRLMSTFEMDARYKGFTEGTYNNKKETAKILKQLGDSIQKIMQVTGLPEEEIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KD3</accession>
    <name>Q73KD3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972885.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680176.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2285"/>
    <dbReference type="EnsemblBacteria" id="AAS12804">
        <property type="protein sequence ID" value="AAS12804"/>
        <property type="gene ID" value="TDE_2285"/>
    </dbReference>
    <dbReference type="GeneID" id="2740035"/>
    <dbReference type="KEGG" id="tde:TDE_2285"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2155"/>
    <dbReference type="eggNOG" id="ENOG5032M6Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_566114_0_0_12"/>
    <dbReference type="OMA" id="ILEYRCK"/>
    <dbReference type="OrthoDB" id="397678at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="470" mass="53541" checksum="D05D75976AE93BA8" modified="2004-07-05" version="1">MLKHNSFFIYLFISLNVLFAQENIYDKILEYRCKNDTDIVLIENEAAIALNNYKSVRLNSIFAFDFSSTLNFNLSSEKDKSGFSVQPSVSAGMPLYNNLGLKLSAPYSYKMGKSSQDFSLGLSGDIYSQARKRKKQEIETSLEALKEAEKKVKSVKELAEKKLLTDIQKILSEYSALLAKRLSGIQADINYKQILAEGYSETSSKLRTARLNLISSERTEKETEFSFEVSARLFFESCGLDIPKKDEDEFFIRLAKSLPKQKLISMENLKAENYKPLLKAENDYKKLLEKNKMDLSPFSASASLGYSYTMNQNKNISSGLQLMFPGVRLDTGLSLSLDSASVPAMQVSFSINPLAIYDYYLNKKNVSLKEAGEKIKLGNTRNNFAKEFNTFKLKWEQLEWQQIRYAEELDIYKENAEEHAKWFQRGLINALENKQASLQYITALLGSADSNIAVHIFNAELKEAFDIEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KI0</accession>
    <name>Q73KI0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972838.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12757">
        <property type="protein sequence ID" value="AAS12757"/>
        <property type="gene ID" value="TDE_2238"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2238"/>
    <dbReference type="HOGENOM" id="CLU_3259298_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="42" mass="4790" checksum="E6A62F1060EB64C4" modified="2004-07-05" version="1">MLFFSKIYCTQQHILPVRLHRFTAMDGGGSKLPRVLDASLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KI8</accession>
    <name>Q73KI8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972830.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2230"/>
    <dbReference type="EnsemblBacteria" id="AAS12749">
        <property type="protein sequence ID" value="AAS12749"/>
        <property type="gene ID" value="TDE_2230"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2230"/>
    <dbReference type="HOGENOM" id="CLU_2048685_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="120" mass="14180" checksum="52710E7C2679B6FC" modified="2004-07-05" version="1">MSVLNNSNAVFSTVFFCSIKNLPFLNQKANKTNSILLGKGEEFVQQYFLPFQSRRKVETLHNNPQVCRIPKRGRQQFLTLYSNPNRELLYHIPRELTEKFVLFCEFHNLQKTYHTSQVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KP6</accession>
    <name>Q73KP6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972772.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680012.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2171"/>
    <dbReference type="EnsemblBacteria" id="AAS12691">
        <property type="protein sequence ID" value="AAS12691"/>
        <property type="gene ID" value="TDE_2171"/>
    </dbReference>
    <dbReference type="GeneID" id="2740193"/>
    <dbReference type="KEGG" id="tde:TDE_2171"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2050"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088936_0_0_12"/>
    <dbReference type="OMA" id="PIWKECY"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="60"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="254" mass="29374" checksum="9F4F2E472E81D7F9" modified="2004-07-05" version="1">MNNYIKLNEDRWNNVKNDYTEPLTHEELEEVRNNSISVALTVGKKVPKEWFEKANGKKILGLACGGGQQGPVFAIKGYDVTIMDFSKSQLQRDDMVAKREDLKINTVQGDMTKPFPFENETFDIIFNPVSNVYIEDLENMYKEASRVLKKGGLLMVGFMNPWIYMYDADIVWDKPDEELLLKFSIPFNSKELEEEGKITINPEYGYEFSHTLETQIRGQLKNGLAMIDFYESCDKRHRLSCYGNDYIATLCIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KQ0</accession>
    <name>Q73KQ0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridine nucleotide-disulphide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972768.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680008.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2167"/>
    <dbReference type="EnsemblBacteria" id="AAS12687">
        <property type="protein sequence ID" value="AAS12687"/>
        <property type="gene ID" value="TDE_2167"/>
    </dbReference>
    <dbReference type="GeneID" id="2739153"/>
    <dbReference type="KEGG" id="tde:TDE_2167"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2048"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014111_0_0_12"/>
    <dbReference type="OMA" id="KCISVFD"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="846"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="914" mass="101881" checksum="22E32CA9726D4FBE" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KR5</accession>
    <name>Q73KR5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972753.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668137.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2152"/>
    <dbReference type="EnsemblBacteria" id="AAS12672">
        <property type="protein sequence ID" value="AAS12672"/>
        <property type="gene ID" value="TDE_2152"/>
    </dbReference>
    <dbReference type="GeneID" id="2739138"/>
    <dbReference type="KEGG" id="tde:TDE_2152"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2033"/>
    <dbReference type="eggNOG" id="COG3027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116623_5_0_12"/>
    <dbReference type="OMA" id="DQSPQHM"/>
    <dbReference type="OrthoDB" id="2053327at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="99" mass="11243" checksum="E22B70C13B74D89D" modified="2004-07-05" version="1">MSKGQLNIDVLGTSFAIQANETDEYLSRIYNHYLNVLDQVKQTSKVSDPLKLAILTGILVTDELYKEEFSGQNSQELIQKACDMEKSAMRMIEKINEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L71</accession>
    <name>Q73L71_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972597.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1994"/>
    <dbReference type="EnsemblBacteria" id="AAS12508">
        <property type="protein sequence ID" value="AAS12508"/>
        <property type="gene ID" value="TDE_1994"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1994"/>
    <dbReference type="HOGENOM" id="CLU_3367954_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="35" mass="4484" checksum="709623C5CC2B8729" modified="2004-07-05" version="1">MTFYYYFMKKMIYVVKFWEKIEIFFAPCPFFVLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LE2</accession>
    <name>Q73LE2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972526.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1923"/>
    <dbReference type="EnsemblBacteria" id="AAS12437">
        <property type="protein sequence ID" value="AAS12437"/>
        <property type="gene ID" value="TDE_1923"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1923"/>
    <dbReference type="HOGENOM" id="CLU_2959481_0_0_12"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="59" mass="6727" checksum="A152CEF10ACCE934" modified="2004-07-05" version="1">MYIFNLRVLLCKTLEAGTTAIHSGMQNPRLCKKLIEMILSDTIGKIAYISIQHNINTYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LE5</accession>
    <name>Q73LE5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972523.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679626.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1920"/>
    <dbReference type="EnsemblBacteria" id="AAS12434">
        <property type="protein sequence ID" value="AAS12434"/>
        <property type="gene ID" value="TDE_1920"/>
    </dbReference>
    <dbReference type="GeneID" id="2740418"/>
    <dbReference type="KEGG" id="tde:TDE_1920"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1817"/>
    <dbReference type="eggNOG" id="ENOG5032FZA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130453_0_0_12"/>
    <dbReference type="OMA" id="MNDANRF"/>
    <dbReference type="OrthoDB" id="1884588at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285958" evidence="1">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="119" mass="13349" checksum="931A7A3AFF512BF2" modified="2004-07-05" version="1">MKRFALFFLFLISLSLLACSKEDPLQTLDLPSDSAMNDANRFALIIETYVSLLDKPGDDGITVSHARKFDVFPVEGLEIVKEDGEQVLWVNLGKGWIQRSSVQLYSSKEKVLTAAKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LP5</accession>
    <name>Q73LP5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972421.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957063.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1817"/>
    <dbReference type="EnsemblBacteria" id="AAS12332">
        <property type="protein sequence ID" value="AAS12332"/>
        <property type="gene ID" value="TDE_1817"/>
    </dbReference>
    <dbReference type="GeneID" id="2739247"/>
    <dbReference type="KEGG" id="tde:TDE_1817"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1727"/>
    <dbReference type="eggNOG" id="ENOG5032MUT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943143_0_0_12"/>
    <dbReference type="OrthoDB" id="2114326at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="277" mass="33128" checksum="BD9E77D19504F18F" modified="2004-07-05" version="1">MKKKYLLIVIIFSLIFINCKQNRELLFEKMISSASKRKEKIYLSFNDANQKSGNKYYDYIINSKGINLDYYYKWALTNQETNFVFELMNCELTTGDLALSILWDRFRFDDENMEGLFPIEIVDKYRKTGSNNLYKWVQEDINHRVYITNKTMEIILQKEGVNREININEIKKSIMKKYVKGRDYIITCEFLRWGPTVTGVSWPKYYLWINIFNPNSYELVAEGAIRVALIENEKESQKLDITDFIKFDDNKQNIQEFEKVFPHAIVEQIAYRNDIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LV7</accession>
    <name>Q73LV7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972359.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1755"/>
    <dbReference type="EnsemblBacteria" id="AAS12270">
        <property type="protein sequence ID" value="AAS12270"/>
        <property type="gene ID" value="TDE_1755"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1755"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1678"/>
    <dbReference type="HOGENOM" id="CLU_3349895_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="37" mass="4455" checksum="B43E2AF2486DE36E" modified="2004-07-05" version="1">MNLQNKIRNTHNITKKGLDVKSKIRYYLTIFKEFKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M09</accession>
    <name>Q73M09_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972306.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679410.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1702"/>
    <dbReference type="EnsemblBacteria" id="AAS12217">
        <property type="protein sequence ID" value="AAS12217"/>
        <property type="gene ID" value="TDE_1702"/>
    </dbReference>
    <dbReference type="GeneID" id="2740874"/>
    <dbReference type="KEGG" id="tde:TDE_1702"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1627"/>
    <dbReference type="HOGENOM" id="CLU_122423_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284596" evidence="1">
        <location>
            <begin position="27"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="185" mass="21715" checksum="FE1079112ACA05DD" modified="2004-07-05" version="1">MFLKRKIDLVKKSLFLCLFLIMGSFAATLNAAEKAEFVINDEPFIYKGVSLIPWKKYTREEIEKKLGKPDWHEDNPGGWCRSYEEKIIFNFNQENSFDGLAFNHPEKLKGLNIYGLLISKNDNHSSIVKKLIELKKNFNIIYKTNYRRLKFEITIKSKFGNIKLIINCSDSDKQEVTDVSLWYMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M18</accession>
    <name>Q73M18_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972297.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679397.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1693"/>
    <dbReference type="EnsemblBacteria" id="AAS12208">
        <property type="protein sequence ID" value="AAS12208"/>
        <property type="gene ID" value="TDE_1693"/>
    </dbReference>
    <dbReference type="GeneID" id="2740148"/>
    <dbReference type="KEGG" id="tde:TDE_1693"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1619"/>
    <dbReference type="eggNOG" id="ENOG5031D3G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1061474_0_0_12"/>
    <dbReference type="OrthoDB" id="2114375at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285830" evidence="1">
        <location>
            <begin position="24"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="262" mass="29062" checksum="51392EA5690BBE66" modified="2004-07-05" version="1">MKKLSFTVAAAAVVVGMVLLCTACQFDGQKIVDQFLLGSYGTYSWNSDNTKLTIKSNENNFQKHFAGLGKNSVTLKKETVGAAKYLTSPEYYLDAKSMDGDVWQGIFYLNGYGFRTIKITLKSGGRCEIQPGLSVEEGIKFPEDLTITGSLESNAGKILPKAPSTTGMPTYTKQFFAAVKSDSLKTKWVDDNEVETFTYYRKDQENMMVTETWKGSPQLFVKGTDAGVYYKRILKYDNTNTFVSGTFEIFIPKGTALPAVFP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M34</accession>
    <name>RS18_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsR</name>
        <name type="ordered locus">TDE_1676</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972281.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M34"/>
    <dbReference type="SMR" id="Q73M34"/>
    <dbReference type="STRING" id="243275.TDE_1676"/>
    <dbReference type="EnsemblBacteria" id="AAS12192">
        <property type="protein sequence ID" value="AAS12192"/>
        <property type="gene ID" value="TDE_1676"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1676"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1602"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148710_0_3_12"/>
    <dbReference type="OMA" id="QKKYCRF"/>
    <dbReference type="OrthoDB" id="1940575at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000111253" description="30S ribosomal protein S18">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <sequence length="89" mass="10537" checksum="147975375D683AE0" modified="2004-07-05" version="1">MEANMQENIREGEDKRKGRSFYRKKVCRFCAQKVKIDYKEPDALRRFITERGKILPRRITGTCAKHQRKLAVEIKRARAVALLPFVMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M74</accession>
    <name>Q73M74_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972241.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679319.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1635"/>
    <dbReference type="EnsemblBacteria" id="AAS12152">
        <property type="protein sequence ID" value="AAS12152"/>
        <property type="gene ID" value="TDE_1635"/>
    </dbReference>
    <dbReference type="GeneID" id="2739744"/>
    <dbReference type="KEGG" id="tde:TDE_1635"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1563"/>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149290_2_0_12"/>
    <dbReference type="OMA" id="NYGEQRF"/>
    <dbReference type="OrthoDB" id="2065431at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="95" mass="11469" checksum="CF8B063FF0ED7B59" modified="2004-07-05" version="1">MIFEWDEIKNETNIKKHDGISFKIAARVFLDSKRIEKYDEQHSTLEEQRWNAIGLVEDVLFVVFTERKNDIIRIISARKANQEEINEYYSNYDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M86</accession>
    <name>Q73M86_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH HARE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972229.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679309.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1623"/>
    <dbReference type="EnsemblBacteria" id="AAS12140">
        <property type="protein sequence ID" value="AAS12140"/>
        <property type="gene ID" value="TDE_1623"/>
    </dbReference>
    <dbReference type="GeneID" id="2740864"/>
    <dbReference type="KEGG" id="tde:TDE_1623"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1551"/>
    <dbReference type="eggNOG" id="COG2958">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074541_1_0_12"/>
    <dbReference type="OMA" id="PRKYYYS"/>
    <dbReference type="OrthoDB" id="703698at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007759">
        <property type="entry name" value="Asxl_HARE-HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05066">
        <property type="entry name" value="HARE-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51913">
        <property type="entry name" value="HTH_HARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HTH HARE-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="320" mass="37324" checksum="9C43353EC245F9A1" modified="2004-07-05" version="1">MEKQYTFFDLIIEVFEKVKKPMTPEEVWEKAVEFSFDKKLGSSGKTPAATVGARLYVDAKEKAEKSTFIQVSKRPSRFILRSLNISGSEIKREIEKKENAELKQNNESNFNERDLHPLLVKYVYSNPHFNCYTKTIYQENSVKRVKGANEWLHPDLVGVYFPFKDYSKETMKLQTSLNVNSIKLFSFEMKKNIDYSNLRQYFFQAVSNSSWANEGYLVCLKIDEDPNFRNELQRLSNAFGIGIIKLNAENISESEIICNARYNENIDWDTLERLSEDNPDFNKFISDLTEDIALGKVKSTYDKVITDDKFENYLKEKSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MA1</accession>
    <name>Q73MA1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972214.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679291.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1608"/>
    <dbReference type="EnsemblBacteria" id="AAS12125">
        <property type="protein sequence ID" value="AAS12125"/>
        <property type="gene ID" value="TDE_1608"/>
    </dbReference>
    <dbReference type="GeneID" id="2740849"/>
    <dbReference type="KEGG" id="tde:TDE_1608"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1537"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_8_2_12"/>
    <dbReference type="OMA" id="YYDEIFP"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="239" mass="27485" checksum="9630233C67B6BE0C" modified="2004-07-05" version="1">MNVYDLIAEHYSGLFPLETEKLEFIQHLCPLPGRLCDAGCATGELVMGLYQKGYDICGLDLNEKMIGIAEKKASCIRKTGELMFYHADIADIMQFGKFKGVLCFGNTLPHLRDEEALRRFFGSVYRSLEEHGIFIVEVLNYDRILDDKKMDFKDKETKDFIFKRNYDFLPGGNIRFTIEFTDKQRSTVGSDFTVLHPLKRQMLLALFKQTGFKSVSAYSDYSFTESRAEDYAVVYTANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MD2</accession>
    <name>Q73MD2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972183.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678265.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12094">
        <property type="protein sequence ID" value="AAS12094"/>
        <property type="gene ID" value="TDE_1577"/>
    </dbReference>
    <dbReference type="GeneID" id="2739774"/>
    <dbReference type="KEGG" id="tde:TDE_1577"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1506"/>
    <dbReference type="eggNOG" id="ENOG50302BP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1041848_0_0_12"/>
    <dbReference type="OMA" id="ISDNEVM"/>
    <dbReference type="OrthoDB" id="1148574at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285840" evidence="2">
        <location>
            <begin position="23"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="285" mass="32631" checksum="97114B68712A5409" modified="2004-07-05" version="1">MKKKLLFFLIFISILFSTFITSCSNNKEKEIVYEKIKPKRIIKNNILIVLGKDYYERKDILKYLENEYALGSPDSHVRVLPYSDMVKATKQPRLRMINEKIEEQKTTILISIGIPEGGGRYLIQAAENNPELSIISLLPMDEILPLEAASDIVVDFQIPKEIMNEEKDFLISDNEVMLLLVAAIFAGEDINAHKKNIKIFPIEEFQQAFFTAQTILGKTLFTNHHYTIKPYTDSDTGLQSHRYILIYKDFDESQETDISDDKENSGENETENDGIINPDKLEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MG0</accession>
    <name>Q73MG0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein TDE_1548</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972154.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1548"/>
    <dbReference type="EnsemblBacteria" id="AAS12065">
        <property type="protein sequence ID" value="AAS12065"/>
        <property type="gene ID" value="TDE_1548"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1548"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1484"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140930_4_1_12"/>
    <dbReference type="OrthoDB" id="1883809at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="95" mass="10178" checksum="A6C19B1D3D24D9B5" modified="2004-07-05" version="1">MKNAKEIQAKIANIKSDLDQEVVEGVSGGGLVKIRLKGSFEVESIFLDPIAVDNRDVPMLQDLVRAAHNDAVAKLKELLQNKLGPLASLAGGLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MI6</accession>
    <name>Q73MI6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[Citrate [pro-3S]-lyase] ligase</fullName>
            <ecNumber evidence="1">6.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">citC</name>
        <name evidence="3" type="ordered locus">TDE_1522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP + holo-[citrate lyase ACP] = acetyl-[citrate lyase ACP] + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23788"/>
            <dbReference type="Rhea" id="RHEA-COMP:10158"/>
            <dbReference type="Rhea" id="RHEA-COMP:13710"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82683"/>
            <dbReference type="ChEBI" id="CHEBI:137976"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.22"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.2.1.22" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972128.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679169.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1522"/>
    <dbReference type="EnsemblBacteria" id="AAS12039">
        <property type="protein sequence ID" value="AAS12039"/>
        <property type="gene ID" value="TDE_1522"/>
    </dbReference>
    <dbReference type="GeneID" id="2739728"/>
    <dbReference type="KEGG" id="tde:TDE_1522"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1461"/>
    <dbReference type="eggNOG" id="COG3053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063190_0_0_12"/>
    <dbReference type="OMA" id="YVFVLSE"/>
    <dbReference type="OrthoDB" id="1354563at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008771">
        <property type="term" value="F:[citrate (pro-3S)-lyase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02169">
        <property type="entry name" value="Citrate_lyase_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005216">
        <property type="entry name" value="Citrate_lyase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013166">
        <property type="entry name" value="Citrate_lyase_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40599">
        <property type="entry name" value="PTHR40599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08218">
        <property type="entry name" value="Citrate_ly_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005751">
        <property type="entry name" value="Acet_citr_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00764">
        <property type="entry name" value="Citrate_ly_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Citrate_ly_lig" evidence="2">
        <location>
            <begin position="151"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="342" mass="38823" checksum="6C40122D7EF41491" modified="2004-07-05" version="1">MTNLQKINLELKSQKEKFTALLKENGLIADSLESVYGIFDEADNLAACGGREKNILKCFAVKDEFKGLGLTDEILSALLKDAYGEGYKFFFIFTKRSSVSFFTGAGFINLASSDDSSLLYRGEKTVEKVLKNELFPYCPDGILGSISDEGNAAIVMNANPFTLGHRYLIEKALDYCGSKSRLFVFAVETDKSFFSFNDRFMLIKKNTEDLKNVVVLPSSQFLISGATFPSYFLKEKSLISKNQTQLDARIFLKYFVPLFNIKIRFLGEEPLDPSTEIYNQTLLNELPPQCEVKIIERKKTQNQQIISATQVRKAFQNNSLEEVRSFLPEITYNFLRSLKQKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MK1</accession>
    <name>Q73MK1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-serine dehydratase</fullName>
            <ecNumber evidence="8">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">sdhB</name>
        <name evidence="10" type="ordered locus">TDE_1507</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="8"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972113.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671219.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1507"/>
    <dbReference type="EnsemblBacteria" id="AAS12024">
        <property type="protein sequence ID" value="AAS12024"/>
        <property type="gene ID" value="TDE_1507"/>
    </dbReference>
    <dbReference type="GeneID" id="2739713"/>
    <dbReference type="KEGG" id="tde:TDE_1507"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1446"/>
    <dbReference type="eggNOG" id="COG1760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086592_0_0_12"/>
    <dbReference type="OMA" id="HTAGACR"/>
    <dbReference type="OrthoDB" id="1720141at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004643">
        <property type="entry name" value="Fe-S_L-Ser_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036692">
        <property type="entry name" value="SDH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00719">
        <property type="entry name" value="sda_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="146"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS12024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="220" mass="23631" checksum="1A44860D61D316A9" modified="2004-07-05" version="1">MDIFDIIGPIMIGPSSSHTAGAVRIGYLTRVLLAEPAIKARVYLHGSFAYTYKGHGTDRAIAAGIMGMKPENERIRNSLTLAKEQGLDITFEPIDIPNAHPNTALIEVTGIDGKELSVQGSSIGGGNILITKINGKPVELSGKNPTLVVEYQDIPGRIAAITSVTAKHKINISQIHIGRDYRGGTATMCLQMDGLSVGPELKEDILQIDHIYNVILIQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MK6</accession>
    <name>Q73MK6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chorismate mutase</fullName>
            <ecNumber evidence="2">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroH</name>
        <name evidence="3" type="ordered locus">TDE_1502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.4.99.5" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972108.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679161.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1502"/>
    <dbReference type="EnsemblBacteria" id="AAS12019">
        <property type="protein sequence ID" value="AAS12019"/>
        <property type="gene ID" value="TDE_1502"/>
    </dbReference>
    <dbReference type="GeneID" id="2739903"/>
    <dbReference type="KEGG" id="tde:TDE_1502"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1441"/>
    <dbReference type="eggNOG" id="COG4401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133236_1_1_12"/>
    <dbReference type="OMA" id="CIRVMMT"/>
    <dbReference type="OrthoDB" id="2021052at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02185">
        <property type="entry name" value="AroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008243">
        <property type="entry name" value="Chorismate_mutase_AroH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21164">
        <property type="entry name" value="PTHR21164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07736">
        <property type="entry name" value="CM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005965">
        <property type="entry name" value="Chor_mut_AroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01796">
        <property type="entry name" value="CM_mono_aroH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51167">
        <property type="entry name" value="CHORISMATE_MUT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>prephenate</name>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR005965-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="125" mass="13860" checksum="8728CAF934FA7E3E" modified="2004-07-05" version="1">MSLIKKLRALRGAVCCEDSEESISSAAVNLYSRILRENSLSEKDIVSIHFTVTSDIRALNPASALRKNGFAKNTALFCALEPGMKGGLPKTIRILIYYYSRKKPIHIYMGGAEVLRPDLISKTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MK9</accession>
    <name>Q73MK9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylosuccinate lyase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972105.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679156.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1499"/>
    <dbReference type="EnsemblBacteria" id="AAS12016">
        <property type="protein sequence ID" value="AAS12016"/>
        <property type="gene ID" value="TDE_1499"/>
    </dbReference>
    <dbReference type="GeneID" id="2739900"/>
    <dbReference type="KEGG" id="tde:TDE_1499"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1438"/>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_0_1_12"/>
    <dbReference type="OMA" id="TQVNPCD"/>
    <dbReference type="OrthoDB" id="347727at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006188">
        <property type="term" value="P:IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013539">
        <property type="entry name" value="PurB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08328">
        <property type="entry name" value="ASL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="2">
        <location>
            <begin position="387"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="480" mass="53846" checksum="DEEFBACCD423D634" modified="2004-07-05" version="1">METRSIFKNISPIDHRYSLPQGGLYDELSVFLSEEAGIVYCAMAEMAIVKAHLKIAEEKKGSLLPKLSGELEKTLDDIALNIDPSEVYEEEHKTQHNIRALVNVLKKKVPENTAPLVHLGATSADILDTAFSMRIRDAVIKVIIPLLKKTELLLCDIAEREAETPQVGRTHGQHAVPITFGYAVSEYVARLGKSILKMEDLVKDLRGKFAGAVGAYNAASLIVSDPMRFEKIYLDYLGLKPSEYSHQLVEPEYMLRLLLEANIAFGIIANLADDLRNLQRTEIGEVFEYFSATQVGSSTMPQKRNPWNSEHVKSLWKAFSPRIMSFYMDQISEHQRDLSNSASQRFIADYLTGLALAFNRMNSILKGLQADRENMLKNLLQGGGKVRGGVMAEPAYILLAECGVSDAHEVIRKITLAAENQKISFYEALKAEEKVFALVTERLKELNFDKPEEFFANPERYRGLANVKAKALAEKYKALM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MQ8</accession>
    <name>MUTS2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease MutS2</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mutS2</name>
        <name type="ordered locus">TDE_1450</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972056.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679109.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MQ8"/>
    <dbReference type="SMR" id="Q73MQ8"/>
    <dbReference type="STRING" id="243275.TDE_1450"/>
    <dbReference type="EnsemblBacteria" id="AAS11967">
        <property type="protein sequence ID" value="AAS11967"/>
        <property type="gene ID" value="TDE_1450"/>
    </dbReference>
    <dbReference type="GeneID" id="2741413"/>
    <dbReference type="KEGG" id="tde:TDE_1450"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1391"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011252_2_1_12"/>
    <dbReference type="OMA" id="IHAIIND"/>
    <dbReference type="OrthoDB" id="256392at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01069">
        <property type="entry name" value="mutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000093411" description="Endonuclease MutS2">
        <location>
            <begin position="1"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="743"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="352"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <sequence length="818" mass="92265" checksum="7AED37B69936A209" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MR4</accession>
    <name>Q73MR4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972050.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679079.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1444"/>
    <dbReference type="EnsemblBacteria" id="AAS11961">
        <property type="protein sequence ID" value="AAS11961"/>
        <property type="gene ID" value="TDE_1444"/>
    </dbReference>
    <dbReference type="GeneID" id="2741407"/>
    <dbReference type="KEGG" id="tde:TDE_1444"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1385"/>
    <dbReference type="eggNOG" id="COG1236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_5_2_12"/>
    <dbReference type="OMA" id="YLDGMIW"/>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="15"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="257"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="470" mass="53185" checksum="F145B60DACB3D7CC" modified="2004-07-05" version="1">MAIKFYSLGAAEEVTGSKHILEVDGHKYLIDCGAFQGKRAEADKKNRDFNVPAPELEAVILTHGHYDHCGLLPLLGKHGFTGNIYATPATRDIANLVMMDSARIQARDREYLSKQAAKKGETFKWVPLFDEADVIQTVNQFVTISYHRPAWIGPNVQLEFYDAGHILGSAMAVITAKDSDGKEVKIAFTGDLGRKNKAIIRDPDIIPPVDYIVIESTYGNRRHEETDNALKLLAEKTQEIVQNKGKMIIPAFAVERTQEIVYYFHLLVDKRIIPDIPIYVDSPMAVNATSIFQVHPECYDAQTHEAFLIHHKNPFGFNSLKFITSVAESKELNNIDGPMVIISADGMCEFGRITHHLANNIEKPSTKVLLVGFMAEDTLGRRLQNKEQEVKIFGEWHQVRAEILQINAFSAHADYFESREWLDSLKNPKLKTIFLVHGEPKAQTYFTQYLNENGYNDVKTVKYGRTYKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MX3</accession>
    <name>Q73MX3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971989.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1383"/>
    <dbReference type="EnsemblBacteria" id="AAS11900">
        <property type="protein sequence ID" value="AAS11900"/>
        <property type="gene ID" value="TDE_1383"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1383"/>
    <dbReference type="HOGENOM" id="CLU_1685793_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="156" mass="16992" checksum="AF638E103503C64D" modified="2004-07-05" version="1">MSEFYIPSVWNTLGRAGKWIIKKKTNTSMSTVMKNIMIITNTVITSISTMNIMNMNTMDTAITIITIITNIATMNIAAVGMTMKKKIAVCVDTITMGTVMMNITTTVPAAMTTTNMTTADTIITGIVMMTIMNIALADTIIQAVAVNIITAPQKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N00</accession>
    <name>Q73N00_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971962.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678920.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1356"/>
    <dbReference type="EnsemblBacteria" id="AAS11873">
        <property type="protein sequence ID" value="AAS11873"/>
        <property type="gene ID" value="TDE_1356"/>
    </dbReference>
    <dbReference type="GeneID" id="2739457"/>
    <dbReference type="KEGG" id="tde:TDE_1356"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1304"/>
    <dbReference type="eggNOG" id="COG3221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_810724_0_0_12"/>
    <dbReference type="OMA" id="VWYPNES"/>
    <dbReference type="OrthoDB" id="988224at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="331" mass="36277" checksum="39E046BF8F307905" modified="2004-07-05" version="1">MKHKIILVLAAVCLFFGCTKNETQKPVTMVFLPNESSDAMKDARQAFMEIISEAVGRPVEIKTTTDYNIALEAIISGNADMAYIGAEGYINAHKRNPAIVPVVTNSGPSGTLEDALYYSFIAVRTEDAAQYKDEDGYDLNRLKGKNISFVSTSSTSGFVIPATLFVKKFGLTGTDELIQGNSVFSKVLFAGSHQGSQVNLFRKDAEAAAFAIPQTIGVYDLIEGEAYQTGAAYKVVEGAIEPFDKFPGSEITIIQSIPVLNAPIVMNTKTLSPEEQNKIQEALTSEKTANNPGIFKIKDSYKKGMYPKYTEKTKLVKTTDAWYDKIRNLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N33</accession>
    <name>Q73N33_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971929.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11840">
        <property type="protein sequence ID" value="AAS11840"/>
        <property type="gene ID" value="TDE_1323"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1323"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1272"/>
    <dbReference type="HOGENOM" id="CLU_3259294_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="42" mass="4624" checksum="08CDF2710A11436E" modified="2004-07-05" version="1">MSIYSYKVTINGQIPLEKKAPFEAFIENASKGGISLVFPAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N39</accession>
    <name>Q73N39_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971923.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678850.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1317"/>
    <dbReference type="EnsemblBacteria" id="AAS11834">
        <property type="protein sequence ID" value="AAS11834"/>
        <property type="gene ID" value="TDE_1317"/>
    </dbReference>
    <dbReference type="GeneID" id="2739575"/>
    <dbReference type="KEGG" id="tde:TDE_1317"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1266"/>
    <dbReference type="eggNOG" id="ENOG502ZZU7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1618269_0_0_12"/>
    <dbReference type="OrthoDB" id="2069143at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="164" mass="18968" checksum="27E92778DDA9117C" modified="2004-07-05" version="1">MHFDKKTLRFLLEFIFIFTIFVLPPMLNKRDFTPPPQPEGFFYVLVFISKIVFFAAYEEILYRIYLPYRIKSFYGENPESFKSAFAVYEILPVIFFALAHRYLGPFNVLYAAAAGIIFRVLYVLIQKKASTKCSITIASIKAALCVIVLHSVHNGIIYLLIFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N66</accession>
    <name>Q73N66_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1289"/>
    <dbReference type="EnsemblBacteria" id="AAS11807">
        <property type="protein sequence ID" value="AAS11807"/>
        <property type="gene ID" value="TDE_1289"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1289"/>
    <dbReference type="HOGENOM" id="CLU_3334243_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="38" mass="4614" checksum="4BD015C86BBA0BC9" modified="2004-07-05" version="1">MKFYVNFFGGKYEKLTKENLFIRNSGNMCVFIYFLFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N67</accession>
    <name>Q73N67_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971895.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1288"/>
    <dbReference type="EnsemblBacteria" id="AAS11806">
        <property type="protein sequence ID" value="AAS11806"/>
        <property type="gene ID" value="TDE_1288"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1288"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1238"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084787_0_0_12"/>
    <dbReference type="OMA" id="CFIGPIA"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="292" mass="34957" checksum="665E5202945CCF3D" modified="2004-07-05" version="1">MEGNINKKVIKDLCILFILYFFAFFMLSYAGKFLFKNFYNYYYTLFVKYNGIFGSLLFLLFIIIFYLFYSKDLKIIFTYKKLNFSFVVKGLIYLSSIMMIYYIISFIFDNSFLFNFFKYFNDVLTGKKNITVYDILILEKLQRPRFEPFMLIGTVIIGPIFEEIFYRGLLYNKLKEISNTLIAVFISSILFAFLHIPGYGFNIKMFSLVLDGILLTYCYEKTDNIYVPILVHSINNFFIFLFKYVYFYFLIVIYFIIFIAGIIMAIQEIKIYLKKRKIFNEVQTDTLAETEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N78</accession>
    <name>Q73N78_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fe-hydrogenase large subunit family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1277</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971884.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678778.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1277"/>
    <dbReference type="EnsemblBacteria" id="AAS11795">
        <property type="protein sequence ID" value="AAS11795"/>
        <property type="gene ID" value="TDE_1277"/>
    </dbReference>
    <dbReference type="GeneID" id="2740570"/>
    <dbReference type="KEGG" id="tde:TDE_1277"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1227"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039046_0_1_12"/>
    <dbReference type="OMA" id="FMTTSCC"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027631">
        <property type="entry name" value="FeFe_hydrog_B1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04105">
        <property type="entry name" value="FeFe_hydrog_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="493" mass="54287" checksum="DFF5C41BADBDF581" modified="2004-07-05" version="1">MLNINNNTSNIKREILVRIAKLQFEGKLQEGVHYIPREMVPRNSTPIRCCIFHDREIMRHRVIARLGCSLENYDEEKTLAQFAKEALEREKPTWPMLTVLDEACNACVKSKYMITNACQACVARPCMMNCPKTAIAISGGRARIDEEKCINCGICLKNCPYHAVIKIPVPCEEACPVGAISKDENGKERIDYHKCIFCGNCMRECPFGAMMDKGQIVDVIKHLMSGKKVSALYAPAVAAQFKAVPGQLESALKKAGFNKVWEVAIGADITADREASEFEERMEHGHILMTTSCCPAYVRAVKKHVPALVPCISDTRSPMHYTAELAKKEDPDCVTVFIGPCLAKRREGLEDEFVDYVLSIEELGALLTAKEIDISKEEALPGKITPTSSGRGFAASGGVAEAVRVRLKKPENLRPVLINGLNKEGMKQLASYGKIQSGELPHDSSTPNLVEVMSCEGGCIGGPSVITNQKLAASQLKKYADEGLSYSREKDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N99</accession>
    <name>Q73N99_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971863.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668533.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1256"/>
    <dbReference type="EnsemblBacteria" id="AAS11774">
        <property type="protein sequence ID" value="AAS11774"/>
        <property type="gene ID" value="TDE_1256"/>
    </dbReference>
    <dbReference type="GeneID" id="2741432"/>
    <dbReference type="KEGG" id="tde:TDE_1256"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1208"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_1_12"/>
    <dbReference type="OMA" id="LYKNCKH"/>
    <dbReference type="OrthoDB" id="1094814at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="136"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="392" mass="44768" checksum="D29563C023771F79" modified="2004-07-05" version="1">MNTYNAEHIKDLSFFNKNVYLDKKFLLLIPETPLTAELKAILNEWDFSLLYSDGEPSSFMSVRTDTASGKDVLDSSKENEIISDKLKKQKEIMEETENKFWDFLRFTDKIFTDYTMKKILEPRLVFDKIKELCDFVKSDKKNILLIEMQKYSSPTNYLVMHSLRSSIFAIIIGLQLKMPPHRLIELGAACLLHEIGMFRLPPQYYMYDAPLSEEGKKALFTHPVLSYNILKTSSFSLPICLGALEHHERENGHGYPRGLTREKISMYGKIIAVACSYEAATAPRPYKEAQDASSGIVEMIKNTNGQYDETILKALLYSLSFYPVGMYVHLSNGKIAKVIDVNPDDPRFPIVQIYGKTTPTGDPVIVQTKANEVTVKRQLSKEELKSIDRNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NP5</accession>
    <name>Q73NP5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nusA</name>
        <name evidence="10" type="ordered locus">TDE_1107</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971715.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682413.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1107"/>
    <dbReference type="EnsemblBacteria" id="AAS11596">
        <property type="protein sequence ID" value="AAS11596"/>
        <property type="gene ID" value="TDE_1107"/>
    </dbReference>
    <dbReference type="GeneID" id="2740237"/>
    <dbReference type="KEGG" id="tde:TDE_1107"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1066"/>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029242_2_1_12"/>
    <dbReference type="OMA" id="MDIDMSA"/>
    <dbReference type="OrthoDB" id="384865at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NusA_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="KH_5" evidence="9">
        <location>
            <begin position="233"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="495" mass="55345" checksum="BA1C3D93D6132FAD" modified="2004-07-05" version="1">MSEGIIEAIREFAQEKGIDDDFVLHIVEQALKASYKKQFGTDANAVFNEETGKIYSKKIITEDAKNPVFDISLEEAKKLAPSCEAGDELLVEVDPKSLGINSVKVGMQRAIQCIREMQKDTLYAEYSTKVGEIIIGYYHRERNGNIYVDLGKVEGLLPKKYQCPGDHFGRNAAAGEESRIKALVREVKKHRQSNVVQLILSRTDAEFVRQILEVEVPEIESGIVKIHNIVREPGYRTKIAVSTDRDDIDPVGACVGAKGARIQAVIAELDDEKIDILPYSEDPKAYIKSALSPAEVMDVMILDAEKRKALAIVSDSQLSLAIGKHGLNVRLANRLVDWNIDVKTEEQFKQMDIYTDARKAVENLFTDETSDEDEEYEEISNVAELPGITEDILTVLRNNEIEDIQDLINMEDDEIRALEGLTTEMADTLLDIIANAVEVVEDDGDESDEESEPVSDDEGEVEEFECPECGHKITTDMTKCPNCGVDLAFEYEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NX3</accession>
    <name>Q73NX3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hsp20/alpha crystallin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971637.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670499.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1029"/>
    <dbReference type="EnsemblBacteria" id="AAS11518">
        <property type="protein sequence ID" value="AAS11518"/>
        <property type="gene ID" value="TDE_1029"/>
    </dbReference>
    <dbReference type="GeneID" id="2741507"/>
    <dbReference type="KEGG" id="tde:TDE_1029"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.990"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_8_4_12"/>
    <dbReference type="OMA" id="WREPFVD"/>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="34"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="146" mass="16454" checksum="D2F8C0E8D9809C4F" modified="2004-07-05" version="1">MNSLSLFSPSFTDSVFDALDRSLGPNFGVFAPIKNASCGMPSVDIRETEKAYVMEVDLPGYSEKDVEISLKDRLMTISSSKKEEKEDKGAEYIIKERSSRHFMRRFTLPEDINSDEVSAKFENGVLVVNIPRKPDTQPKQIEIKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P08</accession>
    <name>Q73P08_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971601.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0992"/>
    <dbReference type="EnsemblBacteria" id="AAS11482">
        <property type="protein sequence ID" value="AAS11482"/>
        <property type="gene ID" value="TDE_0992"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0992"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.954"/>
    <dbReference type="eggNOG" id="COG0212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_2_2_12"/>
    <dbReference type="OMA" id="NTEEYCK"/>
    <dbReference type="OrthoDB" id="1816478at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="167"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="229" mass="26047" checksum="FD81C3988EAF0DB8" modified="2004-07-05" version="1">MNLTQATGNRLKMLKEEKAKVRKLIKEYFKSPKVKSLIQKTEELQNTEEYCKNFLNKIPKYGEAKTVFAYHPINEEFPTLGLLRQAAEDKKTIGLPLVLGKDLVFKKMEFRNGKLEPVQIGTFGIMEPAEEALNLFPQTQEEKKTAPLEFPLLILVPGRAFSKKGERMGRGGGFYDRFFEKLFKSIKKEEVCLAGLCFSGQILDTIPMGEFDHPVDLVVTEAEVYLYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P40</accession>
    <name>Q73P40_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NusG_II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971569.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682268.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0959"/>
    <dbReference type="EnsemblBacteria" id="AAS11450">
        <property type="protein sequence ID" value="AAS11450"/>
        <property type="gene ID" value="TDE_0959"/>
    </dbReference>
    <dbReference type="GeneID" id="2740767"/>
    <dbReference type="KEGG" id="tde:TDE_0959"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.923"/>
    <dbReference type="eggNOG" id="COG5341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130936_3_0_12"/>
    <dbReference type="OMA" id="PIICMPN"/>
    <dbReference type="OrthoDB" id="1864717at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038690">
        <property type="entry name" value="NusG_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024045">
        <property type="entry name" value="NusG_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07009">
        <property type="entry name" value="NusG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="NusG_II" evidence="2">
        <location>
            <begin position="17"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="116" mass="13073" checksum="8B36AA7815514CBC" modified="2004-07-05" version="1">MKKFFKRIRLFDVIMLAVIIVFITSTALFIYSADSSTLYLSVRTPKGDWIYPMDTDISFVVEGETGPVSIRIENNEAFVVSSTCSNKTCITAPKLKNHGDWNACLPNKVFLSVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P84</accession>
    <name>Q73P84_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971525.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="RefSeq" id="WP_010956836.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0915"/>
    <dbReference type="EnsemblBacteria" id="AAS11406">
        <property type="protein sequence ID" value="AAS11406"/>
        <property type="gene ID" value="TDE_0915"/>
    </dbReference>
    <dbReference type="GeneID" id="2739955"/>
    <dbReference type="KEGG" id="tde:TDE_0915"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.885"/>
    <dbReference type="HOGENOM" id="CLU_2995337_0_0_12"/>
    <dbReference type="OrthoDB" id="714984at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="57" mass="6610" checksum="5DA616BE4369DB3A" modified="2004-07-05" version="1">MAENKGGGKSISRIIFFNYDIMINFSDIIKAKKMPLCHKQYLCDKREDCLERALQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PC0</accession>
    <name>Q73PC0_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="43" mass="4927" checksum="3E59454C69365EC6" modified="2004-07-05" version="1">MKFVLADTSVWSLAFRKKQLTSDDKKLLDYLSNIDLADIGRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PC1</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0878</name>
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    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS11369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS11369">
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    <dbReference type="PATRIC" id="fig|243275.7.peg.848"/>
    <dbReference type="eggNOG" id="COG5450">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179376_0_0_12"/>
    <dbReference type="OMA" id="KENNYAY"/>
    <dbReference type="OrthoDB" id="2064132at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019239">
        <property type="entry name" value="VapB_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09957">
        <property type="entry name" value="VapB_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="65" mass="7687" checksum="D90AFC8BF41C1D52" modified="2004-07-05" version="1">MATNLAINEELLDTAYKIGGYSTKKETVNTALEEFIKRRKSEDLIKLFGQVEYDPHYNYKKMRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PG0</accession>
    <name>Q73PG0_TREDE</name>
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            <fullName evidence="2">Rhodanese-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
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            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0839"/>
    <dbReference type="EnsemblBacteria" id="AAS11330">
        <property type="protein sequence ID" value="AAS11330"/>
        <property type="gene ID" value="TDE_0839"/>
    </dbReference>
    <dbReference type="GeneID" id="2739616"/>
    <dbReference type="KEGG" id="tde:TDE_0839"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.808"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097478_0_0_12"/>
    <dbReference type="OMA" id="QECTVDD"/>
    <dbReference type="OrthoDB" id="1385159at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Rhodanese-like_dom"/>
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    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
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    <dbReference type="Pfam" id="PF00581">
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        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="142"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="235" mass="27046" checksum="84B94BC75D6C82F4" modified="2004-07-05" version="1">MKIRFLLFIVLIVNISLISCGIEVEVEDVKGSRLEYLNSDSNKDSILVIDVRPYDKYKQGHLSHAINIPLNEIKNRLREITDWKDKPVYVYSETNDESFKAAEILVGNRFSQIYNAEGVNQYNYKTVTYNSVRGIVFEEMLKDPDALILDCRTKSFYDIGHIEGAISFPIFEIENNLDKIPDKNKKLLLYCNVGTASSRAAYELSNLGYTKIYNSIDGVAEYPFKLVREEEEDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PH2</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ordered locus">TDE_0827</name>
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    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971437.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0827"/>
    <dbReference type="EnsemblBacteria" id="AAS11318">
        <property type="protein sequence ID" value="AAS11318"/>
        <property type="gene ID" value="TDE_0827"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0827"/>
    <dbReference type="HOGENOM" id="CLU_2977929_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="58" mass="6526" checksum="01A751BB0C81466F" modified="2004-07-05" version="1">MGVFYSCLVSASPIYKRLIQKLPKGLPPFGIRHCYKVFGLFFRQGKNKVVGINLKGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PQ6</accession>
    <name>Q73PQ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971352.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956807.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73PQ6"/>
    <dbReference type="STRING" id="243275.TDE_0741"/>
    <dbReference type="EnsemblBacteria" id="AAS11233">
        <property type="protein sequence ID" value="AAS11233"/>
        <property type="gene ID" value="TDE_0741"/>
    </dbReference>
    <dbReference type="GeneID" id="2740295"/>
    <dbReference type="KEGG" id="tde:TDE_0741"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.715"/>
    <dbReference type="eggNOG" id="COG4964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_412742_0_0_12"/>
    <dbReference type="OrthoDB" id="1490218at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284997" evidence="2">
        <location>
            <begin position="36"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="3">
        <location>
            <begin position="70"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="3">
        <location>
            <begin position="135"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="3">
        <location>
            <begin position="230"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="657" mass="70362" checksum="C18623B387289CED" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PW1</accession>
    <name>Q73PW1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971297.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681896.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73PW1"/>
    <dbReference type="STRING" id="243275.TDE_0685"/>
    <dbReference type="EnsemblBacteria" id="AAS11178">
        <property type="protein sequence ID" value="AAS11178"/>
        <property type="gene ID" value="TDE_0685"/>
    </dbReference>
    <dbReference type="GeneID" id="2740244"/>
    <dbReference type="KEGG" id="tde:TDE_0685"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.665"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_9_12"/>
    <dbReference type="OMA" id="MSEKVWF"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="265" mass="29469" checksum="BA848E24499385D4" modified="2004-07-05" version="1">MEKIAIVAGGSSGIGLEITKALVLKDYFVYTMSRREFLSLPQEKSKHISLDITDEENLTKAFSDIWEKEGRIDLAVCASGFGISGAVEFTNLEEAKKQMDVNFFGAFLFIKTAASYMRPQSFGKIFVISSIAGEIAIPFQGFYSASKAALGKLLEAFRAELQPFGVDCALIMPGDVATPFTAARNKSNLGDDVYNGRISKSVSKMEKDEQKGMNPEKLGKFVACLAEKRKVGFFYPYNWTYSFLLLLYRILPRSLALFIVKKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PX6</accession>
    <name>Q73PX6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971282.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681874.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0669"/>
    <dbReference type="EnsemblBacteria" id="AAS11163">
        <property type="protein sequence ID" value="AAS11163"/>
        <property type="gene ID" value="TDE_0669"/>
    </dbReference>
    <dbReference type="GeneID" id="2739662"/>
    <dbReference type="KEGG" id="tde:TDE_0669"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.650"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057504_0_2_12"/>
    <dbReference type="OMA" id="YINISKM"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="292" mass="34328" checksum="702A54237B45E03F" modified="2004-07-05" version="1">MEKLFKITLRNDYAFKKVFGVEENKDVLQDLLECILDIPPEDIAGLELLDKEFHKEFLSEKLGILDIKLRLNNGTFVDIEIQNVWYFDFPERTLYYWSKMYNEGIKQGQDYTKLPKCITINLIGKGFNKNKRLHNKYLVLEKDTKEPLVSKLEIHILNLEKARLLKEGQYKDYKAKRLLNWLKFIETDEREVREVLEQESPMMRKANTTIELMEMSPRDKWLYESRMKYEHDKASCISEGYRQGIEQGIQQGFADGAHQNKLETARNLTEMGFAVEVIAKATGLSIEEIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q26</accession>
    <name>Q73Q26_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971232.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0618"/>
    <dbReference type="EnsemblBacteria" id="AAS11113">
        <property type="protein sequence ID" value="AAS11113"/>
        <property type="gene ID" value="TDE_0618"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0618"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.596"/>
    <dbReference type="HOGENOM" id="CLU_3349893_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="37" mass="4039" checksum="2F2E126F6D81532D" modified="2004-07-05" version="1">MFKGDTPLKSSPITPKKEKCGLGTYAPKNPVFSKSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q39</accession>
    <name>Q73Q39_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971219.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956784.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0605"/>
    <dbReference type="EnsemblBacteria" id="AAS11100">
        <property type="protein sequence ID" value="AAS11100"/>
        <property type="gene ID" value="TDE_0605"/>
    </dbReference>
    <dbReference type="GeneID" id="2739161"/>
    <dbReference type="KEGG" id="tde:TDE_0605"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.585"/>
    <dbReference type="HOGENOM" id="CLU_1348431_0_0_12"/>
    <dbReference type="OMA" id="HLYNMQV"/>
    <dbReference type="OrthoDB" id="1714979at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="194" mass="21967" checksum="04F7F2C8692A1809" modified="2004-07-05" version="1">MAKKASETKTTKKAKTPAKAAAKKTAKTSAKKTISAYKQSAAEKKLVTELAELTKQMDAEGLLFLIEQARVHLYNMQVEALEEDLQAIEEKRAKTVSVKKAQPKKDFRIERASDGSVYHIISGGKWKLINADELFSILKIVNAKLDDNEIRLNLIHWFFKERGDFVGDLGLADTHDPRWLELIKLLKTNFKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QD0</accession>
    <name>Q73QD0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4261 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971127.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956760.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0513"/>
    <dbReference type="EnsemblBacteria" id="AAS11008">
        <property type="protein sequence ID" value="AAS11008"/>
        <property type="gene ID" value="TDE_0513"/>
    </dbReference>
    <dbReference type="GeneID" id="2739610"/>
    <dbReference type="KEGG" id="tde:TDE_0513"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.499"/>
    <dbReference type="eggNOG" id="ENOG502ZA5G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065762_1_0_12"/>
    <dbReference type="OMA" id="YEIMAYK"/>
    <dbReference type="OrthoDB" id="1629859at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025357">
        <property type="entry name" value="DUF4261"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14080">
        <property type="entry name" value="DUF4261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4261" evidence="1">
        <location>
            <begin position="165"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="240" mass="27065" checksum="DB0315A3C5F0982E" modified="2004-07-05" version="1">MPMFKGDRGYSLDKVIQDLKSYWGLKVGEIEGDDNTATFKIDEELVALALMPAPIPAAEFESIYNYSYLWKDAEKEIQEHTQHAIVSLLGSNTPAVERYSLLSKLNASILRTCETAIGIYQGASTLLLPKNLYIDFTDLLLDDILPIQLWVYIGIINSDEKSSVYTYGMKEFGKSEIEIIDAKMKGSELYDFLLPVLDYVLQQDVTLQHGETIGFTEEQKIKITESKAVFLDGNSLKLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QD8</accession>
    <name>Q73QD8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971119.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002665928.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0505"/>
    <dbReference type="EnsemblBacteria" id="AAS11000">
        <property type="protein sequence ID" value="AAS11000"/>
        <property type="gene ID" value="TDE_0505"/>
    </dbReference>
    <dbReference type="GeneID" id="2739602"/>
    <dbReference type="KEGG" id="tde:TDE_0505"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.491"/>
    <dbReference type="eggNOG" id="COG3041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161929_4_1_12"/>
    <dbReference type="OMA" id="DHRECHV"/>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004386">
        <property type="entry name" value="Toxin_YafQ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40588">
        <property type="entry name" value="PTHR40588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15738">
        <property type="entry name" value="YafQ_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006156">
        <property type="entry name" value="YafQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00053">
        <property type="entry name" value="TIGR00053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="93" mass="11114" checksum="BEB001B6721C5F21" modified="2004-07-05" version="1">MKYEIKFTNQFKKDIKLAKKQNKNLDKLLKVIDLLSNGEKLEAKYRDHDLSGNYKGTRECHIEPDWLLVYEIRNDVLVLMLYRLGSHSELFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QH7</accession>
    <name>Q73QH7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2281 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971080.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672644.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0466"/>
    <dbReference type="EnsemblBacteria" id="AAS10961">
        <property type="protein sequence ID" value="AAS10961"/>
        <property type="gene ID" value="TDE_0466"/>
    </dbReference>
    <dbReference type="GeneID" id="2739220"/>
    <dbReference type="KEGG" id="tde:TDE_0466"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.451"/>
    <dbReference type="eggNOG" id="ENOG5031D14">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163140_9_1_12"/>
    <dbReference type="OrthoDB" id="2097967at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018739">
        <property type="entry name" value="DUF2281"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10047">
        <property type="entry name" value="DUF2281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2281" evidence="1">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="69" mass="8173" checksum="1BF3E151A14AAD82" modified="2004-07-05" version="1">MPYIALEKKINNLTLEQQQSVYDYVNFLLYQNTAAKNQKNIRRKPGGLEGKFYMAEDFDKTPECFKDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QJ9</accession>
    <name>Q73QJ9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamine amidotransferase class-I domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971058.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681526.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0444"/>
    <dbReference type="EnsemblBacteria" id="AAS10939">
        <property type="protein sequence ID" value="AAS10939"/>
        <property type="gene ID" value="TDE_0444"/>
    </dbReference>
    <dbReference type="GeneID" id="2740426"/>
    <dbReference type="KEGG" id="tde:TDE_0444"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.431"/>
    <dbReference type="eggNOG" id="COG2071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030756_2_1_12"/>
    <dbReference type="OMA" id="PEYWAET"/>
    <dbReference type="OrthoDB" id="1628378at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011697">
        <property type="entry name" value="Peptidase_C26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044668">
        <property type="entry name" value="PuuD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43235">
        <property type="entry name" value="PTHR43235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07722">
        <property type="entry name" value="Peptidase_C26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="241" mass="26851" checksum="EBD929B734476AEF" modified="2004-07-05" version="1">MKKPLIGITGSCLYETSQSLFAGYERMYTNADYVNSVLAAGGVPLMLPIIDDEDAIQRQLENLSGIIIMGGHDVEPHFFNEEPLSCLGEILPKRDVYELSLIKAAKALKKPVLGICRGMQILNVAFGGSLYQDLSLIKRDIQIQHVQKARPQERTHSIKTEAASIMQKVFGKEDMVNSYHHMAVKDLAKDFKITAYAPDGVVEAIEYTGEGFIMGVQFHPEMMAAVHKASLDLFKEFINRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QK8</accession>
    <name>Q73QK8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent DNA helicase, RecQ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971049.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681501.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0435"/>
    <dbReference type="EnsemblBacteria" id="AAS10930">
        <property type="protein sequence ID" value="AAS10930"/>
        <property type="gene ID" value="TDE_0435"/>
    </dbReference>
    <dbReference type="GeneID" id="2740581"/>
    <dbReference type="KEGG" id="tde:TDE_0435"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.422"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_9_7_12"/>
    <dbReference type="OMA" id="IAVDECH"/>
    <dbReference type="OrthoDB" id="54580at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="120"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="313"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS10930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="567" mass="63746" checksum="06F164D08ACD0AC1" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QP0</accession>
    <name>Q73QP0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971017.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681431.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0403"/>
    <dbReference type="EnsemblBacteria" id="AAS10898">
        <property type="protein sequence ID" value="AAS10898"/>
        <property type="gene ID" value="TDE_0403"/>
    </dbReference>
    <dbReference type="GeneID" id="2740149"/>
    <dbReference type="KEGG" id="tde:TDE_0403"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.391"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057504_0_2_12"/>
    <dbReference type="OMA" id="DINKEHS"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="284" mass="33631" checksum="665FAEBA9BC0C08E" modified="2004-07-05" version="1">MEKLFKITLRNDYAFKRVFGVEENKDVLQDLLECILDIQPEDIAGLELLDKEFHKDSISDKTGVLDVKLRLKNNTIIDIEIQNRWNSEFVQRTIFYWAKMYTENLKTGEVYTKLPKCITINIVGEGFDLNSLIHSEYNVVEKHLNDRLSDELEIHFLNLAKVKEQDENIESDEKKKKLYNWLKFIETDDEEVRNMLAQESPMMRKANSTIELMEMSPKEKWLYENRMKYEHDKASWKHVGYQEGIEQGSYQKALETARLMKQANCELDFIIQMTGLSKEEIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QR6</accession>
    <name>Q73QR6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970991.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0377"/>
    <dbReference type="EnsemblBacteria" id="AAS10872">
        <property type="protein sequence ID" value="AAS10872"/>
        <property type="gene ID" value="TDE_0377"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0377"/>
    <dbReference type="HOGENOM" id="CLU_3405971_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3553" checksum="CCBD037CE06C26A9" modified="2004-07-05" version="1">MSFEKNKIENNLKIAQAYIYIKPKPRICQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QT7</accession>
    <name>Q73QT7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970970.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681342.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0356"/>
    <dbReference type="EnsemblBacteria" id="AAS10851">
        <property type="protein sequence ID" value="AAS10851"/>
        <property type="gene ID" value="TDE_0356"/>
    </dbReference>
    <dbReference type="GeneID" id="2740163"/>
    <dbReference type="KEGG" id="tde:TDE_0356"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.345"/>
    <dbReference type="eggNOG" id="COG4925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099043_2_1_12"/>
    <dbReference type="OMA" id="MRDVNGN"/>
    <dbReference type="OrthoDB" id="1961657at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041183">
        <property type="entry name" value="Cyclophilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18050">
        <property type="entry name" value="Cyclophil_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclophil_like2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="118" mass="13013" checksum="2086170C02711476" modified="2004-07-05" version="1">MKITITANGKTLTASLYDNSSSRALVELLQKGAITIEMHDYGNFEKVGDLPISLPRNDKQTNTDAGDLILYQGKSFVIYYDKNSWNFTLLGKLEGITKAELKKLLGTGNVTVILENAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QW5</accession>
    <name>Q73QW5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">cas1</name>
        <name evidence="9" type="ordered locus">TDE_0328</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970942.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681291.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0328"/>
    <dbReference type="EnsemblBacteria" id="AAS10823">
        <property type="protein sequence ID" value="AAS10823"/>
        <property type="gene ID" value="TDE_0328"/>
    </dbReference>
    <dbReference type="GeneID" id="2741544"/>
    <dbReference type="KEGG" id="tde:TDE_0328"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.317"/>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055263_1_0_12"/>
    <dbReference type="OMA" id="GHFRAYK"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019855">
        <property type="entry name" value="CRISPR-assoc_Cas1_NMENI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03639">
        <property type="entry name" value="cas1_NMENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="290" mass="33381" checksum="C5224A25F7543D4C" modified="2004-07-05" version="1">MSWRTVVISNRAKLDLHLNHLVVRGEKTQKVFIEEISVLIIETTAVSITAALLNELIKQKVKVIFCDEKRNPASELIGYYGSHDTSEKIRLQIKWDKNIKQLVWTEVVTEKIRQQKYLLEKLNLPQASLLAEYITDIDINDKTNKEAHAAKAYFAALFGAGFSRSLDIPINAALNYGYSILLSAFNREIIANGYITQLGIFHDNMFNPFNLGSDLMEPFRPLVDAEVFKLNPQKFEHEEKLKIVSVINKKVLINNKEHYLNKAIEIFVHSIFDALNEKDISQINFYRNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QX3</accession>
    <name>Q73QX3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TDE_0320</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970934.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681279.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0320"/>
    <dbReference type="EnsemblBacteria" id="AAS10815">
        <property type="protein sequence ID" value="AAS10815"/>
        <property type="gene ID" value="TDE_0320"/>
    </dbReference>
    <dbReference type="GeneID" id="2739327"/>
    <dbReference type="KEGG" id="tde:TDE_0320"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.309"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_12"/>
    <dbReference type="OMA" id="DLMIPRV"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="208"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="272"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS10815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="432" mass="48389" checksum="9B654B33283EECBE" modified="2004-07-05" version="1">MKFELALMIIEFIALLFCAFFFSATETAITAITRTEYKAIKKSRTKKSRRLAFLIERKDEIVSATLIGTNFVNTLSSALITAFVIDMYGQQHIPAATAITTVLIIIFAEILPKAVAAYNAVEITKTFLVPLSVVRLFLKPFIFVFSLMSNFIIKLVSKKQNNQSSELSEDYLETLINISLADGTFQTGEHELIKRAVRLHELKLQSIMTKKEDIVSLDINSSLENMVSIFRKTMFSRLPVYKGEKDKIIGSVHYKDILFYRSHNTEMDINKIIRRALFIPKTANIFSAIKTMSKNKRNMAFVIDEYGSTAGLITIDDISTAIFGSIQDEYSKTKTNPLSGMKIVDGTHILIPGAVPIIQLNSILNTDFHSDYNDTIGGLILETAEYLPKEGELITIGEVDFKVEKVETSKIISLIADVSKLTAGAQFPKAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QY5</accession>
    <name>Q73QY5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970922.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0308"/>
    <dbReference type="EnsemblBacteria" id="AAS10803">
        <property type="protein sequence ID" value="AAS10803"/>
        <property type="gene ID" value="TDE_0308"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0308"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.297"/>
    <dbReference type="eggNOG" id="ENOG502ZUN4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_834039_0_0_12"/>
    <dbReference type="OMA" id="GMEYRYR"/>
    <dbReference type="OrthoDB" id="1968322at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285911" evidence="1">
        <location>
            <begin position="21"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="349" mass="40160" checksum="6761C79E40274401" modified="2004-07-05" version="1">MKKILCLIFCFMMTAGFSQNKEELKNNNEEESLNISKFNILPHYFGFPLSVKFGWLYRQNNFSVFPNTGIFFSADNGPAISSSIGMFVQKDFFKWDINAFYDFVPFTMHKKASDQIVYARNNFIFVINRLKISFPARVGRRLVNEIKFTGSQKELLPKTITEISQGIRFDVYLADLGYLKATTSFSFFTDWIPESRFVNYRLKFDLPVTFKLYYVDVGFVYTFYNTGRINSKNINAAADYQIEKSQEAMTRRFSFKDVQKYSSMHIWGAEIRWYAARTGVNSSGFFISAFADAGFGSNEVKKINLIAECGLGAGYTLFDNVPFTFQAGFNQDFKPIFFLGVVSRIIQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R07</accession>
    <name>Q73R07_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_0286</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970900.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681225.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0286"/>
    <dbReference type="EnsemblBacteria" id="AAS10781">
        <property type="protein sequence ID" value="AAS10781"/>
        <property type="gene ID" value="TDE_0286"/>
    </dbReference>
    <dbReference type="GeneID" id="2741603"/>
    <dbReference type="KEGG" id="tde:TDE_0286"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.276"/>
    <dbReference type="eggNOG" id="COG4987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523662_0_0_12"/>
    <dbReference type="OrthoDB" id="580239at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="317"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="349"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="536" mass="60477" checksum="C3B79A6E4C533A5D" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R14</accession>
    <name>Q73R14_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676624.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0279"/>
    <dbReference type="EnsemblBacteria" id="AAS10774">
        <property type="protein sequence ID" value="AAS10774"/>
        <property type="gene ID" value="TDE_0279"/>
    </dbReference>
    <dbReference type="GeneID" id="2741596"/>
    <dbReference type="KEGG" id="tde:TDE_0279"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.269"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049285_1_1_12"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="324" mass="36802" checksum="51B756820085B783" modified="2004-07-05" version="1">MNKTRKTVIKNNKISHISEFNLGGFSQKVLVEGKRDDLPILITLHGGPGTPIPLCVGCRGMFPEFTDNFITVCWDQLGCGINNYKIDDNFTINRFVQMTCDLIDSIKKEFPNNKLFIFSASWGSILSLSVTEKKAKVIDGVLAIGQIVKNIFYNEEVYNALKESGVSERIINRIKNTDIDNIKSKDLQLVSCLLRKKTNAYNNKKSKPLEIGKIILGLFQSPDYTFKDFKAMFINGYKDNISLWNEILRIDLSEKLKNVSVPYYILQGETDIVSPTKIIKELCESSGNKNLHYRVVGNSGHLPNKEMMEELFKVLLSIKRIFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R23</accession>
    <name>Q73R23_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970884.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956708.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0270"/>
    <dbReference type="EnsemblBacteria" id="AAS10765">
        <property type="protein sequence ID" value="AAS10765"/>
        <property type="gene ID" value="TDE_0270"/>
    </dbReference>
    <dbReference type="GeneID" id="2741254"/>
    <dbReference type="KEGG" id="tde:TDE_0270"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.262"/>
    <dbReference type="HOGENOM" id="CLU_813629_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="341" mass="39794" checksum="A0C1054C8BE80823" modified="2004-07-05" version="1">MKKIFFLTVVYCSLLISCKNNSDGKKLSYDGKILTEQLTQREFDYSKAKEELNRERTDSRIPFTMNFYGCLGKPVLKAEGNNDVYVMLDSGSTRNWFYYSLLEKINVTEDDFIQKVVEYIKQNELELIKNHSSEKEVAQYLKNEWSNYNLNYLASVSFGDISLRYDPNVNETFDGVLGAEFLLNYDRVTIDFINQYIILNDEKLDGAALKMYQSPNDEFDIYFEYRGQPEFGMIDTGNYGFTPRHNFGDRNQQYDINDYSNYGYGYKDKVPITPRVMYSYNDIKIGEVIYNNMNGAYSTIKGSGFNKGAQSHMMKLNGLGNVFFYNHIIQFDFVDMQFIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R44</accession>
    <name>Q73R44_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970863.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681167.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10744">
        <property type="protein sequence ID" value="AAS10744"/>
        <property type="gene ID" value="TDE_0248"/>
    </dbReference>
    <dbReference type="GeneID" id="2741447"/>
    <dbReference type="KEGG" id="tde:TDE_0248"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.243"/>
    <dbReference type="eggNOG" id="COG3189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137928_1_0_12"/>
    <dbReference type="OMA" id="RRWFGHR"/>
    <dbReference type="OrthoDB" id="1831995at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="122" mass="14214" checksum="9DEB92FA868B5F42" modified="2004-07-05" version="1">MGKLLWKRVYDLPEKGDGFRILADRLWPRGISKEKACISEWAKEITPSSGLRQAYHRSEIDYKTFSELYAKELVQNPCTKDFTDKIKAELKNRNVTVLYANKDVEQSHIPVLQRFIEKVLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R46</accession>
    <name>Q73R46_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0245</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970861.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681164.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0245"/>
    <dbReference type="EnsemblBacteria" id="AAS10742">
        <property type="protein sequence ID" value="AAS10742"/>
        <property type="gene ID" value="TDE_0245"/>
    </dbReference>
    <dbReference type="GeneID" id="2741444"/>
    <dbReference type="KEGG" id="tde:TDE_0245"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.240"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OMA" id="ANRTGQM"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="328"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="361"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="572" mass="63511" checksum="C003BE6497E2F1AF" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R98</accession>
    <name>Q73R98_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970809.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0193"/>
    <dbReference type="EnsemblBacteria" id="AAS10690">
        <property type="protein sequence ID" value="AAS10690"/>
        <property type="gene ID" value="TDE_0193"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0193"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.189"/>
    <dbReference type="eggNOG" id="ENOG5033VMJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_403286_0_0_12"/>
    <dbReference type="OMA" id="HIPVRTI"/>
    <dbReference type="OrthoDB" id="666201at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="658" mass="76020" checksum="906FCFB913DE80CA" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RA3</accession>
    <name>Q73RA3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine/AMP deaminase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970804.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681076.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0188"/>
    <dbReference type="EnsemblBacteria" id="AAS10685">
        <property type="protein sequence ID" value="AAS10685"/>
        <property type="gene ID" value="TDE_0188"/>
    </dbReference>
    <dbReference type="GeneID" id="2741035"/>
    <dbReference type="KEGG" id="tde:TDE_0188"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.184"/>
    <dbReference type="eggNOG" id="COG1816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039228_2_0_12"/>
    <dbReference type="OMA" id="ANSKSIM"/>
    <dbReference type="OrthoDB" id="554648at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="PTHR43114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A_deaminase" evidence="3">
        <location>
            <begin position="147"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="299" mass="34060" checksum="5AEF435DC9AD8163" modified="2004-07-05" version="1">MRDFDYYKKQPKADTHNHLNLSMEYSDYKKWAGFEIPNFPRKMNGLDEMHEIIGQYTRPACTTAQHVIDLIEMSIMTAIKDNVVCIEGSVDIGFIKQFNENLDAFLEGISGIVKKYKNKIKIIPELGISKTIDQSFLKQWIEPMISSKVFKNIDLYGPEVSEGIEQCVYIFKLAEKYGLKKKAHVGEFSDAASVKYFVEMFNLDEVQHGIGAAQNDKVLQFLADRKIRCNVCPQSNIMLGAAKDLKSHPLRKMMDAGVPISIGTDDILFFGKTNSEQFYDLVSEKVITEEEADQLMAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RB7</accession>
    <name>Q73RB7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TDE_0174</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970790.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681057.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0174"/>
    <dbReference type="EnsemblBacteria" id="AAS10671">
        <property type="protein sequence ID" value="AAS10671"/>
        <property type="gene ID" value="TDE_0174"/>
    </dbReference>
    <dbReference type="GeneID" id="2739347"/>
    <dbReference type="KEGG" id="tde:TDE_0174"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.171"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025154_2_1_12"/>
    <dbReference type="OMA" id="VYFPGSP"/>
    <dbReference type="OrthoDB" id="241792at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="150"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase_C" evidence="11">
        <location>
            <begin position="358"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS10671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="478" mass="53659" checksum="9CA31526263027E2" modified="2004-07-05" version="1">MIDNALFSDFYELTMAQGFWKKGNNTKTVFEMFFRSNPFKGGYSVFAGLEPLLKTIQNFHFEKSDIDWLKSLGIFEKDFLEYIAGFKFSGNIWAMKEGSLVFPNEPLIRIEADTVEALLLEGLILNMINFQTLIATKTARIWLASKKGSIMEFGLRRAQGNDGAMSATRAAYIGGAFGTSNSLAAKELGIPALGTMAHSWIMSFKSEEDAFQAYADMYPDNSIFLIDTYDTLRSGIVNAIKVGKRLQEKGKNFGVRLDSGDIYYLSKDVRKRLDEAGCTKAKISVSNELTEEIVESLVQNNAPIDSWGVGTHMVTGGNEASLTGVYKMAARKSLGEAEWTPVMKFSDNPAKMTNPACKQVWRLYNPDGTFKADVLTLEDEKIEEGVEQTFYHPANDYQNFTFTPTKIEALLEKRIENGKAVGKAPSLKEIKAYAEKQLDSLDYTSKRLLNPHIYKVSLSEKMRDLKQQLIKNKPVFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RE6</accession>
    <name>Q73RE6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine ABC transporter, thiamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970760.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681007.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0143"/>
    <dbReference type="TCDB" id="3.A.1.19.2">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10641">
        <property type="protein sequence ID" value="AAS10641"/>
        <property type="gene ID" value="TDE_0143"/>
    </dbReference>
    <dbReference type="GeneID" id="2739298"/>
    <dbReference type="KEGG" id="tde:TDE_0143"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.141"/>
    <dbReference type="eggNOG" id="COG4143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_6_1_12"/>
    <dbReference type="OMA" id="PTTNWMY"/>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13545">
        <property type="entry name" value="PBP2_TbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005948">
        <property type="entry name" value="ThiB-like"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01254">
        <property type="entry name" value="sfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285041" evidence="1">
        <location>
            <begin position="24"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="336" mass="36798" checksum="7970D1E32EA1DE8D" modified="2004-07-05" version="1">MKNHLRSILIFSFLIIGCAALFAGGAKESDGTKVVVYTTKSFAADYGPGPKIAELFKAKTGKEVEYVICKEGILNRVILEGKASTADVLIGIDNHLIEKARKAKVLKAYKPTAADKIDSAVLIADDWLLTPFDYGYFAFMFDTKAKIKKPSSLKELIEPAYAKKIVILDPSSSTTGLGLAAWTRAVFGDNYLDFWKALKPNIFAMAPKWSTGYGYFTAGEAPIAISYTSSLASHVLYDKTDRFQPLIFEEGHIIQIEGMGIAANAANTKGAKEFIDFMLTEEAQSLLPETQFMYPVIKGLALPASYKDVPKPAKVLRIPSEDQTESVNAVINVLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RH9</accession>
    <name>Q73RH9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="7">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="7">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pheS</name>
        <name evidence="9" type="ordered locus">TDE_0109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680967.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="EnsemblBacteria" id="AAS10607">
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        <property type="gene ID" value="TDE_0109"/>
    </dbReference>
    <dbReference type="GeneID" id="2741724"/>
    <dbReference type="KEGG" id="tde:TDE_0109"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.109"/>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_2_2_12"/>
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    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00282">
        <property type="entry name" value="Phe_tRNA_synth_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022917">
        <property type="entry name" value="Phe_tRNA_ligase_alpha_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
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    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="263"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="515" mass="58108" checksum="36403258913E8FA9" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RJ1</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="TDE_0097"/>
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    <dbReference type="HOGENOM" id="CLU_106303_3_0_12"/>
    <dbReference type="OMA" id="NLIFMFP"/>
    <dbReference type="OrthoDB" id="1382593at2"/>
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    <dbReference type="InterPro" id="IPR012545">
        <property type="entry name" value="DUF1697"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439">
        <property type="entry name" value="PTHR36439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08002">
        <property type="entry name" value="DUF1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008502">
        <property type="entry name" value="UCP008502"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="174" mass="19917" checksum="7A0FC916F7A095F0" modified="2004-07-05" version="1">MDYIALLRGINVGNSIKINMKELKTLFEQCGFSNVSTYINSGNVIFKSNDKKNSITENIEKALHITSGNEVKVLVKTKSEVVEIANSIPGDWQNNDDLKTDVAYLFESIDNENIINELPIKKEYIQVIYVKGALIWNVRREDYNKSHLNKIISHKAYKDMTIRNVNTARYLAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RJ3</accession>
    <name>Q73RJ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970712.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673249.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0095"/>
    <dbReference type="EnsemblBacteria" id="AAS10593">
        <property type="protein sequence ID" value="AAS10593"/>
        <property type="gene ID" value="TDE_0095"/>
    </dbReference>
    <dbReference type="GeneID" id="44155124"/>
    <dbReference type="KEGG" id="tde:TDE_0095"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.95"/>
    <dbReference type="HOGENOM" id="CLU_216967_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="47" mass="5499" checksum="2CEA082A1C6CDA7E" modified="2004-07-05" version="1">MKTLLRFIKSNRKSGNPQRSELLTPQEKIQEQALVWKAHVGVNYFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RJ4</accession>
    <name>Q73RJ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
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            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970711.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0094"/>
    <dbReference type="EnsemblBacteria" id="AAS10592">
        <property type="protein sequence ID" value="AAS10592"/>
        <property type="gene ID" value="TDE_0094"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0094"/>
    <dbReference type="HOGENOM" id="CLU_3141865_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="49" mass="5961" checksum="9A8374578395AD5F" modified="2004-07-05" version="1">MGLDFLEITAIKRKKLQVFLNFYTKIHKILLKSLDLFIFLKYIRCIKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RL8</accession>
    <name>Q73RL8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma-70 factor, region 2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0070"/>
    <dbReference type="EnsemblBacteria" id="AAS10568">
        <property type="protein sequence ID" value="AAS10568"/>
        <property type="gene ID" value="TDE_0070"/>
    </dbReference>
    <dbReference type="GeneID" id="2741685"/>
    <dbReference type="KEGG" id="tde:TDE_0070"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.71"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_5_12"/>
    <dbReference type="OMA" id="HEQLGRW"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="275" mass="31742" checksum="C5FECCB4B42841E7" modified="2004-07-05" version="1">MTENLLLQYIKDSKKYPLLSAEQEAELADEVKKGNTEAIEVLVTSNLRLVIKMAKKFSSNENQILELIQEGNMGLMKAASKFSKSFKVRFSSYAAWWIKQSFIRYLNSADKVIKLPVRKEALIRQVHKEEENYKIKYGILPSYSQLAEIMKEKVDIIAQIKSFNYTDICSLDDPVDNERSANLYDFIPCNTYNPEEEFIDNEFKEKLNKCLEILNDREKDVLRNRYGLDGTMTSTTFAVLGKKYSISAESIRQTQLRALKKLRADTNKIKAMVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RM1</accession>
    <name>Q73RM1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970684.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673293.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0067"/>
    <dbReference type="EnsemblBacteria" id="AAS10565">
        <property type="protein sequence ID" value="AAS10565"/>
        <property type="gene ID" value="TDE_0067"/>
    </dbReference>
    <dbReference type="GeneID" id="2741682"/>
    <dbReference type="KEGG" id="tde:TDE_0067"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.68"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694328_0_0_12"/>
    <dbReference type="OMA" id="ERIWFIY"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="199"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="415" mass="46963" checksum="6857F1DAC7826D1B" modified="2004-07-05" version="1">MLQLSFLNFKKGSYILIEGKSDTDHFYIIQSGKVQVAKEDEVVAEEGGNVLGPGDFLGVVSCMSGHTQIETAIALTDALLISVPYGQFPHLIEKNTSVAMKIIYSFSKKMRYLDEALTRITLKRNVVTGISHLFTIGEYYLRMSKFDLALYAYYHYLKAQPKGEFADAAQKRVMAIKAMGVKIPMEVLEPPTNQMIRLYDKEHMIFCECQSGTELYIIQKGHVKITKILDNNEVLLAVLKEGDMFGEMALLENKPRSASAIVTEEGCQLLAVNRQNFNQMVSTQPQLIARLTTTFADRIWAMYKQLANTLIKDHVEKMYDMLAIQLEKSRIKPVKGKYHTFNFGPVELANMCGIPKEEVSEAVTKFLKQPIVRCDGSKISITDELELSKQAAYFKKMQEIEKSRINARAKSGGYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RN3</accession>
    <name>Q73RN3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flagellar biosynthesis protein FlhA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">flhA</name>
        <name evidence="8" type="ordered locus">TDE_0055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970672.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002684593.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0055"/>
    <dbReference type="EnsemblBacteria" id="AAS10553">
        <property type="protein sequence ID" value="AAS10553"/>
        <property type="gene ID" value="TDE_0055"/>
    </dbReference>
    <dbReference type="GeneID" id="2741670"/>
    <dbReference type="KEGG" id="tde:TDE_0055"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.57"/>
    <dbReference type="eggNOG" id="COG1298">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015346_3_0_12"/>
    <dbReference type="OMA" id="MAINPGQ"/>
    <dbReference type="OrthoDB" id="436367at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042194">
        <property type="entry name" value="FHIPEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042193">
        <property type="entry name" value="FHIPEP_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042196">
        <property type="entry name" value="FHIPEP_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006301">
        <property type="entry name" value="FlhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005419">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00949">
        <property type="entry name" value="TYPE3IMAPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01398">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS10553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="698" mass="76631" checksum="16B6B0E63F4ECEC0" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RN4</accession>
    <name>Q73RN4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase, iron-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970668.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676322.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0051"/>
    <dbReference type="EnsemblBacteria" id="AAS10549">
        <property type="protein sequence ID" value="AAS10549"/>
        <property type="gene ID" value="TDE_0051"/>
    </dbReference>
    <dbReference type="GeneID" id="2741666"/>
    <dbReference type="KEGG" id="tde:TDE_0051"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.53"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_12"/>
    <dbReference type="OMA" id="LPHIMEY"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="383" mass="41606" checksum="490C588FBB57F84D" modified="2004-07-05" version="1">MADFVFKLSSKVILGNYSLARIGEEVVKFGNNFMFVVDPFFEDMGLVDKVRKSLEEKNISLFVFNGFEQTADSEVIERALSLARGAHIRGVIACGDMTACAIGRAIAALYNEDKPVYRYIEGEPITAESLPLIQVPTTCCDPFLFGNSSFIVDSRNRTVNLLKIKEDLCDLVIFDSNTYAGLAPNAMTSMIFAGLCSTFEAYVSTRGSFFSETILGKAVEIFLISLDPQHEKLVGMPREELVAQAACLSAIGIAASAPGLGTAIALAAGGRYRISKSLIATILLPHVINDAISSSLSKTVAVARMLGETMLEGGDAAEVAKRGVEEIRRRLAEANLPIRLKDIDLTIESLVPVAEDAARLSFMNYSPRPLANHDIFEIIKQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RN7</accession>
    <name>Q73RN7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970665.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680905.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0048"/>
    <dbReference type="EnsemblBacteria" id="AAS10546">
        <property type="protein sequence ID" value="AAS10546"/>
        <property type="gene ID" value="TDE_0048"/>
    </dbReference>
    <dbReference type="GeneID" id="2741663"/>
    <dbReference type="KEGG" id="tde:TDE_0048"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.50"/>
    <dbReference type="eggNOG" id="ENOG5030VJJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1304413_0_0_12"/>
    <dbReference type="OrthoDB" id="1843992at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="211" mass="24309" checksum="F8667C2ED9BBEF67" modified="2004-07-05" version="1">MKKIKTVFFMTILVFILTGCELLDSLAKETEIIKQIKDEDLRGYTVTWLIFADDSDALKSAAYKKAASYYKKTSENAGLKDQFQIIVVSDGIEKAIREKVKEAGFDADCFPLKWNGNVKNKYNPNDKKNYSVFFDKNGRALFSMTEDWKFENYGGLADYSLEAAGLNNINELKNPLTFFNTLNKFKEDDIFKFINNAVNLNQKDILRYFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RP3</accession>
    <name>Q73RP3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphate acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pta</name>
        <name evidence="6" type="ordered locus">TDE_0042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.8" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970659.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666863.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0042"/>
    <dbReference type="EnsemblBacteria" id="AAS10540">
        <property type="protein sequence ID" value="AAS10540"/>
        <property type="gene ID" value="TDE_0042"/>
    </dbReference>
    <dbReference type="GeneID" id="2741657"/>
    <dbReference type="KEGG" id="tde:TDE_0042"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.44"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019723_0_1_12"/>
    <dbReference type="OMA" id="TMLVKMG"/>
    <dbReference type="OrthoDB" id="1301815at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008959">
        <property type="term" value="F:phosphate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012147">
        <property type="entry name" value="P_Ac_Bu_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004614">
        <property type="entry name" value="P_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
        <property type="entry name" value="P_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00651">
        <property type="entry name" value="pta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTA_PTB" evidence="5">
        <location>
            <begin position="3"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="335" mass="35718" checksum="8A1F8C3B0AA2371D" modified="2004-07-05" version="1">MSFVDEMKRKAKMYANRLVLPEGTEERTLKAARSIVDEKLVSELFLIGSDDAVYAAASKAGVKLGGIKIIDPKKSEWLDSFAESYYEKRKAKGMTLEQAKIEMSAELGFAAMMLVQDKADAMVAGALNTTADVLRAGLKVIGTLPGMKTASSCFLMDTKNPKLGANGVFIFSDCAVIPTPSSEQLADIACSAAISCRTFAGVEPIVAMLSFSTKGSGGDKDENILRVREAVKILQERKPDFVFDGEIQLDCAIVPSVMQKKAADSPVKGQANTLIFPDLGAGNIGYKLVQRIAGAEALGPFLQGFAKPISDLSRGCSVDDIITTSAVTLVQAGRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-06-07" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>P61987</accession>
    <name>CBID_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalt-precorrin-5B C(1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.195</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cobalt-precorrin-6A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cbiD</name>
        <name type="ordered locus">TDE_1595</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:26285"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60063"/>
            <dbReference type="ChEBI" id="CHEBI:60064"/>
            <dbReference type="EC" id="2.1.1.195"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbiD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972201.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669153.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61987"/>
    <dbReference type="SMR" id="P61987"/>
    <dbReference type="STRING" id="243275.TDE_1595"/>
    <dbReference type="DrugBank" id="DB09130">
        <property type="generic name" value="Copper"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12112">
        <property type="protein sequence ID" value="AAS12112"/>
        <property type="gene ID" value="TDE_1595"/>
    </dbReference>
    <dbReference type="GeneID" id="2739792"/>
    <dbReference type="KEGG" id="tde:TDE_1595"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1525"/>
    <dbReference type="eggNOG" id="COG1903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041273_1_0_12"/>
    <dbReference type="OMA" id="YHGKLIK"/>
    <dbReference type="OrthoDB" id="1282567at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043780">
        <property type="term" value="F:cobalt-precorrin-5B C1-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046140">
        <property type="term" value="P:corrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="PTHR35863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="SSF111342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00312">
        <property type="entry name" value="cbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000141689" description="Cobalt-precorrin-5B C(1)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00787"/>
        </source>
    </evidence>
    <sequence length="363" mass="39700" checksum="1BFDCA84511D87BC" modified="2004-06-07" version="1">MKLDLYIDKDGQKLRCGYTTGSCAAAAAKAAALILGGETMTSVKIDTPAGLVLDLPVEHCRSYKNKDGTAIGEAAVQKDAGDDPDSTDGIYIYARVSYRNDGKVLIDGGEGIGRITKKGLFGEVGEAAINPVPRQMIEKEVLKVSKKGFNVEIFSPQGAEIGKKTFNKNIGVEGGISIIGTKGIVYPMSEDAIKKTIYLEIDGILQNSEKKEILLVPGNYGEGLKEKLNTIIDLPTVKISNYIGDSLSYAYSKGFKTMTLLGHIGKFAKLSIGIFNTHNRTADTRMEAFVYYLAMHGADKKTIETVNAFLTAEEAFNYLVENKIEMILKAMERGAEERIKKYLKDDSLSIRVLIYSMKYGLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q3V8B6</accession>
    <name>Q3V8B6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Flagellar biosynthetic protein FliR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fliR</name>
        <name evidence="11" type="ordered locus">TDE_0053</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970670.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673318.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0053"/>
    <dbReference type="EnsemblBacteria" id="AAS10551">
        <property type="protein sequence ID" value="AAS10551"/>
        <property type="gene ID" value="TDE_0053"/>
    </dbReference>
    <dbReference type="GeneID" id="2741668"/>
    <dbReference type="KEGG" id="tde:TDE_0053"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.55"/>
    <dbReference type="eggNOG" id="COG1684">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063626_2_0_12"/>
    <dbReference type="OMA" id="APQFNIF"/>
    <dbReference type="OrthoDB" id="1942709at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
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        <property type="entry name" value="Bac_export_1"/>
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        <property type="entry name" value="TYPE3IMRPROT"/>
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        </location>
    </feature>
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            <end position="143"/>
        </location>
    </feature>
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            <end position="199"/>
        </location>
    </feature>
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        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021717"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS10551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="264" mass="29225" checksum="AF61C4C25D63CB14" modified="2011-07-27" version="1">MQPFDFILDKEPIFLLAAVRIFAILMTSPLMSMRNVSRIAKVALAGLTAFMVTPYAYPNFGNLNAFSLEYLLLLLGEGLIGVLTGFFISILFSTFSTAGQFFSFQMGFGASGVFDALAQVENPLVGQYFNFIAVLIFLRINGFQRLFLGGIMKSIEHVNCFLFLERQEELSTYLLGAVGNLFLNAMIIALPVMGTLILIHITMGLLTKAAPQMNLLSEGFPITILTAFFILALALPFFINTFEIILEKGFSDFWRLLDSLGGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q73IZ5</accession>
    <name>Q73IZ5_TREDE</name>
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        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2782</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AAS13299">
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="283"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="352"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="387"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS13299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="596" mass="66720" checksum="13570AB4444183F1" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J46</accession>
    <name>Q73J46_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, TatD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680785.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2730"/>
    <dbReference type="EnsemblBacteria" id="AAS13247">
        <property type="protein sequence ID" value="AAS13247"/>
        <property type="gene ID" value="TDE_2730"/>
    </dbReference>
    <dbReference type="GeneID" id="2740949"/>
    <dbReference type="KEGG" id="tde:TDE_2730"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2578"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_0_12"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="OrthoDB" id="915852at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="257" mass="29033" checksum="8DD5EEE87A833072" modified="2004-07-05" version="1">MQIFDTHAHVGLIYSDPIEQLRVVQEARQGSVTRIVSICNSLHDFSKVYETLRFSPAVYHAVGVSPSEVTSPGKDWQKTIEESLKLPNVVAVGEIGLDYCKKYGDKRSQIELFIAQLDIASKAGFPVIIHNREAGKDLLDILKERIPKEGGVLHCYSEDDIYAKEALELPLYFSFAGNLTYRNARNLHDTVLALPLDRIVVESESPFMPPSVYRGQRNMPANTIETVKFMAEMLSMDIEELADQLWKNSCTLFRLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J50</accession>
    <name>Q73J50_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide binding domain/GGDEF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973324.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680781.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2726"/>
    <dbReference type="EnsemblBacteria" id="AAS13243">
        <property type="protein sequence ID" value="AAS13243"/>
        <property type="gene ID" value="TDE_2726"/>
    </dbReference>
    <dbReference type="GeneID" id="2740945"/>
    <dbReference type="KEGG" id="tde:TDE_2726"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2574"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_836629_0_0_12"/>
    <dbReference type="OMA" id="ISENTSW"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="185"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="322" mass="35909" checksum="C0A74A164364A7AB" modified="2004-07-05" version="1">MISDGQKIKALSNTPLFAGWDEVYLKDIADMVGIDSYQKGDIIFKQDTRGDRFYIIVEGNVIILSPEDNSVLAEFVSGEMFGETAMLTQEEQKAIASANENSIILSFPKDGIPMEEVFKDNPVTYAQLLKSFLVMVSRRTRKANSLIKENSPIMQELQKQVYGDKLTGLLNKAYLEENIADFMKGSFSLIMMKPDNFKAINDTYGHEKGDACLTFIGNHLSHFLDTDSVLIRYQGNEFAVLTPDQGRDGAASLAEKIKAALENLDISPVVNSPFKLSMSLGVLLYPDTKIEKTEFIKQCSEMPLIGRARGGSQILFEEDINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JB9</accession>
    <name>Q73JB9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalt chelatase</fullName>
            <ecNumber evidence="3">4.99.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbiK</name>
        <name evidence="3" type="ordered locus">TDE_2656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.99.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973254.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680703.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2656"/>
    <dbReference type="EnsemblBacteria" id="AAS13173">
        <property type="protein sequence ID" value="AAS13173"/>
        <property type="gene ID" value="TDE_2656"/>
    </dbReference>
    <dbReference type="GeneID" id="2741101"/>
    <dbReference type="KEGG" id="tde:TDE_2656"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2510"/>
    <dbReference type="eggNOG" id="COG4822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036584_1_1_12"/>
    <dbReference type="OMA" id="FMFVAGD"/>
    <dbReference type="OrthoDB" id="1100154at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016852">
        <property type="term" value="F:sirohydrochlorin cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019251">
        <property type="term" value="P:anaerobic cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010388">
        <property type="entry name" value="Anaerobic_Co-chelatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06180">
        <property type="entry name" value="CbiK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033579">
        <property type="entry name" value="Anaer_Co_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR033579-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR033579-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="251" mass="28607" checksum="416812A19F626C77" modified="2004-07-05" version="1">MKKAIVIASFGTSYAETREKTIDTIEKEAAGRFKDYEIFKAYTSNMVRAILKKRDSINVASPKEIIQELQEKGFSEIYIQPTHIIPGEEYEKLQFENTILGQPLLHENADLDEIIKALELKKPEDDTAIVFMGHGSSHEADKFYEIMQNKLNSQGLENVLIGTVEGSVELKDILPILAERKIKKIELYPFMMVAGDHAHNDMAGNEEDSWYTILKNEGYEVNANLKGLGEYPMIREILYKSLENTINCRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JC6</accession>
    <name>Q73JC6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973247.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680691.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2649"/>
    <dbReference type="EnsemblBacteria" id="AAS13166">
        <property type="protein sequence ID" value="AAS13166"/>
        <property type="gene ID" value="TDE_2649"/>
    </dbReference>
    <dbReference type="GeneID" id="2741094"/>
    <dbReference type="KEGG" id="tde:TDE_2649"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2504"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="IEGHVQY"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="289" mass="33107" checksum="5E70206473CD38F1" modified="2004-07-05" version="1">MISDDVLKIEKLKFSIGRGKKAFSLNDISFSVPRGCVTGLIGENGAGKTTLIRLLLDMYLPESGKVFLFGEELKRENIEIKEKIGFVINDNFFSPLYTAKKAGKFLAGIYKNWNQELYEKYLNDFKIHPSRFLTALSSGTMQKLQIAIALSHGAELLILDEPLNFLDPVSKKEFLDLLRNFMLDENHSILISSHQTNELEKICDEIIFISEGKKIFDSSLENINKNYGLLKIDEKAFKSLYSNDYIGYRKTDYAYEVLVSDKGNQKFTGMVCEDASLEDIMYFYTRRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JE0</accession>
    <name>Q73JE0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973233.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680658.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2635"/>
    <dbReference type="EnsemblBacteria" id="AAS13152">
        <property type="protein sequence ID" value="AAS13152"/>
        <property type="gene ID" value="TDE_2635"/>
    </dbReference>
    <dbReference type="GeneID" id="2740809"/>
    <dbReference type="KEGG" id="tde:TDE_2635"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2491"/>
    <dbReference type="eggNOG" id="COG1247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_4_4_12"/>
    <dbReference type="OMA" id="IFAHNQP"/>
    <dbReference type="OrthoDB" id="1809950at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="166" mass="19341" checksum="34A62B5F4F8A4D74" modified="2004-07-05" version="1">MDIHFNKLTEKYKKETIDIFNYYIEHTTAAYRSEKVDYDFFSALVDENVVSAYAVMNNSNDVIGFCMLEKYKNIRTFNELGDCMYFIKSEMTGKGVGRNMLSLIENDAKQNGIKKLVVDISDENEKSIAFHKKHGFVEYGRLKNCWRKFGRNIGIVYMYKDIGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JF9</accession>
    <name>Q73JF9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2616</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973214.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667217.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2616"/>
    <dbReference type="EnsemblBacteria" id="AAS13133">
        <property type="protein sequence ID" value="AAS13133"/>
        <property type="gene ID" value="TDE_2616"/>
    </dbReference>
    <dbReference type="GeneID" id="2740790"/>
    <dbReference type="KEGG" id="tde:TDE_2616"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2473"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_5_12"/>
    <dbReference type="OMA" id="MEDAWGN"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="219" mass="25442" checksum="83D89189DF43CC44" modified="2004-07-05" version="1">MSDLFSSFSRFAKSFPKGSLIFAEFEPGSSFYLIQSGRVQLIKIINGFEKNLDILQPGEIFGEMAILDNSPRSASAIAYDDVMALEFNKENFEILMKGNPAIAMRLLKTFVRRIYAQRRRFMILTIEDRPARIADVFLMLDETQPNLDRSTEMRSFDTTIEEVARWAGLSKEETEDNMRKFIDQGRISVYDDRIIVQNMTDLTRYVNTRRSKEQNLYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JH6</accession>
    <name>Q73JH6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">tmk</name>
        <name evidence="5" type="ordered locus">TDE_2599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973197.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2599"/>
    <dbReference type="EnsemblBacteria" id="AAS13116">
        <property type="protein sequence ID" value="AAS13116"/>
        <property type="gene ID" value="TDE_2599"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2599"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2457"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_1_3_12"/>
    <dbReference type="OMA" id="QMAYLFA"/>
    <dbReference type="OrthoDB" id="1585072at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="9"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="209" mass="23798" checksum="3B5AF89B222AAB2D" modified="2004-07-05" version="1">MILPNFVVFEGIDGSGTTSQIRLLKERFESEDKSSLVSFTQEPTSGPIGTLIRSALQGSFKLAPETMTRLFAADRCEHIYGLQGILKQVNDGRAVFSDRYVFSSLAYQTAAGAADLAKLQNDGFPLPEFLFFFDLPVDISMNRVMGRSNVLEIYEEKTFQYKVQDEYKKIIDEYRLKEPNMNIVIINAVEQIEEIHEKLWSILKDLPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JI5</accession>
    <name>Q73JI5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Treponemal membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973032.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674029.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2433"/>
    <dbReference type="EnsemblBacteria" id="AAS12951">
        <property type="protein sequence ID" value="AAS12951"/>
        <property type="gene ID" value="TDE_2433"/>
    </dbReference>
    <dbReference type="GeneID" id="2739858"/>
    <dbReference type="KEGG" id="tde:TDE_2433"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2300"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1165409_0_0_12"/>
    <dbReference type="OMA" id="YTVRPWA"/>
    <dbReference type="OrthoDB" id="1649981at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025511">
        <property type="entry name" value="DUF4398"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14346">
        <property type="entry name" value="DUF4398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4398" evidence="1">
        <location>
            <begin position="79"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="233" mass="26801" checksum="2D0FD7A873830E93" modified="2004-07-05" version="1">MKKLITILIFLLVLIPLFALSYDDNEYQRKSRAYMELATKAYDEGDYDAAIEYSKLAESYAQQSSEFIQRMLAKTEAEQEMNKARTRFTWAKANGAEEKYPDAYKTAEEALNAGSIAFDNENYDVAVVCAQRVMDALSVVKGKDDTGLAELPSQYRIRTWRGERDCLWNIAAKKEVYGNPFMWRKLYEANKDKLPDPTNPNWVEPDIILTIPSIKGEKRSGLYDPSISYKHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JJ2</accession>
    <name>Q73JJ2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">nusG</name>
        <name evidence="9" type="ordered locus">TDE_2426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973025.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667597.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2426"/>
    <dbReference type="EnsemblBacteria" id="AAS12944">
        <property type="protein sequence ID" value="AAS12944"/>
        <property type="gene ID" value="TDE_2426"/>
    </dbReference>
    <dbReference type="GeneID" id="2739851"/>
    <dbReference type="KEGG" id="tde:TDE_2426"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2293"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067287_1_1_12"/>
    <dbReference type="OMA" id="DGPFNGF"/>
    <dbReference type="OrthoDB" id="2027986at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="185" mass="20754" checksum="14AC8BEAC35CB055" modified="2004-07-05" version="1">MAKAWYILHTYSGYENKIERTIRTLIEKGIISADFVTDIKIPEELVIENKGGKKRNVKRKFLPGYMLVEMNLPDLGWKSVCSEIRKIQGVTGFLGTAGNEKPQPISPDEAKEILQKTGEIKGDKNIRVIQNFSEGQHVKIIEGAFASFTGVIDEVMADKNKLRVMVAIFGRTTPVEVEMSQAEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JQ8</accession>
    <name>Q73JQ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973049.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957234.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2450"/>
    <dbReference type="EnsemblBacteria" id="AAS12968">
        <property type="protein sequence ID" value="AAS12968"/>
        <property type="gene ID" value="TDE_2450"/>
    </dbReference>
    <dbReference type="GeneID" id="2739635"/>
    <dbReference type="KEGG" id="tde:TDE_2450"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2318"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077687_0_0_12"/>
    <dbReference type="OMA" id="KEREYDF"/>
    <dbReference type="OrthoDB" id="1691070at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="209"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="242"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="300" mass="33952" checksum="F184C9DEBF47F9DB" modified="2004-07-05" version="1">MNVAIFYDEKKKDAAMAIKNIIISHECDVTLYNEDEIWKDENLHTPRHIMKNITHVLFIYSKNPAAYLGFMFFLGYATGLNLPVLVLEESEKLELPKNFLRSFVMLTIKSFESYFEVEKKRFTENQLKELARAKLLENGYSLFIPNYVRAVKNNEKEIVELFIDAGFDPSQKDSLGTPVLSLAVRNKCLETLELLLERGATINLCAEDRNYSALMDAAQVGYIEAVQALLEKKADTNIQSKDGQTALILSVGRREADIVEMLVKHGADYNIKDGLGMSALGYAKLFGDKKILSLFGEQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JR0</accession>
    <name>Q73JR0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973072.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673963.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2474"/>
    <dbReference type="EnsemblBacteria" id="AAS12991">
        <property type="protein sequence ID" value="AAS12991"/>
        <property type="gene ID" value="TDE_2474"/>
    </dbReference>
    <dbReference type="GeneID" id="2739659"/>
    <dbReference type="KEGG" id="tde:TDE_2474"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2340"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_12"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="164" mass="18827" checksum="7BD1D66CE86C22BA" modified="2004-07-05" version="1">MEILIRPTEKKDLPLVKALWADGDVMKFVGFPDGLVQTDEEMARWYDWVLKNSPLSMHYSIFEGEVYCGETWYSIDTVHDNLTSLDIKLFAKARGRGIASKALSFAIEQARLKGAKKVWVNPVPQNEKAIKLYKRLGFSASKVPEHILKKEGEDGYIYMEKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JW6</accession>
    <name>Q73JW6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973119.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2521"/>
    <dbReference type="EnsemblBacteria" id="AAS13038">
        <property type="protein sequence ID" value="AAS13038"/>
        <property type="gene ID" value="TDE_2521"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2521"/>
    <dbReference type="HOGENOM" id="CLU_216968_0_0_12"/>
    <dbReference type="OrthoDB" id="2228567at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="39" mass="4629" checksum="437D9EEF3E8150B8" modified="2004-07-05" version="1">MRANFALLYAVSHFVAKRRKISNAQKLMFLPLAYFNRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JZ2</accession>
    <name>Q73JZ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973145.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2547"/>
    <dbReference type="EnsemblBacteria" id="AAS13064">
        <property type="protein sequence ID" value="AAS13064"/>
        <property type="gene ID" value="TDE_2547"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2547"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2408"/>
    <dbReference type="HOGENOM" id="CLU_2670004_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="75" mass="8818" checksum="386A9F389483E458" modified="2004-07-05" version="1">MLQHDILLEKKLNFFSKTTRQNKKNVYTTPPPEFFAINRISAVPLTYFQKSVFKRANRKTILKNNSRQEAGGFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K04</accession>
    <name>Q73K04_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973159.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680537.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2561"/>
    <dbReference type="EnsemblBacteria" id="AAS13078">
        <property type="protein sequence ID" value="AAS13078"/>
        <property type="gene ID" value="TDE_2561"/>
    </dbReference>
    <dbReference type="GeneID" id="2739926"/>
    <dbReference type="KEGG" id="tde:TDE_2561"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2420"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_12"/>
    <dbReference type="OMA" id="TERVLFM"/>
    <dbReference type="OrthoDB" id="1721927at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="227" mass="25643" checksum="2579CC0699C54F45" modified="2004-07-05" version="1">MVKINSLKFKYPNSKKEVLKNINLEVNQGDYISIVGENGCGKSTLLKLILKLLKIQKGEIIINAKKIGYLPQKKENLNDFPITLFELLNSYRKILKIRESDCALKALERVNLTEYKNSLVGELSGGQLQKLYIARALIGDPDLLILDELSTGIDVQGQKEIYSFVKDLNVKKGLTVISVDHNLDAAIFNSTKIFHIKNGEGHLCNPQQYTSEFFNPNFVQFKPKGEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-01-04" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K67</accession>
    <name>CSRA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translational regulator CsrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">csrA</name>
        <name type="ordered locus">TDE_2355</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsrA/RsmA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972954.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667708.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73K67"/>
    <dbReference type="SMR" id="Q73K67"/>
    <dbReference type="STRING" id="243275.TDE_2355"/>
    <dbReference type="EnsemblBacteria" id="AAS12873">
        <property type="protein sequence ID" value="AAS12873"/>
        <property type="gene ID" value="TDE_2355"/>
    </dbReference>
    <dbReference type="GeneID" id="2739964"/>
    <dbReference type="KEGG" id="tde:TDE_2355"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2223"/>
    <dbReference type="eggNOG" id="COG1551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164837_0_0_12"/>
    <dbReference type="OMA" id="IHRKEVY"/>
    <dbReference type="OrthoDB" id="2032250at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00167">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003751">
        <property type="entry name" value="CsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036107">
        <property type="entry name" value="CsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34984">
        <property type="entry name" value="PTHR34984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02599">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117130">
        <property type="entry name" value="SSF117130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00202">
        <property type="entry name" value="csrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_0000177093" description="Translational regulator CsrA">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00167"/>
        </source>
    </evidence>
    <sequence length="75" mass="8637" checksum="72704BE7D92371C5" modified="2004-07-05" version="1">MLILSRKTNQKILIGDDIEITIIDIRGDQVKIGVDAPPSVKVFREEIYQEIQNENRAALVRDTELNLPELHIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K87</accession>
    <name>Q73K87_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SanA protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972932.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680249.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2333"/>
    <dbReference type="EnsemblBacteria" id="AAS12851">
        <property type="protein sequence ID" value="AAS12851"/>
        <property type="gene ID" value="TDE_2333"/>
    </dbReference>
    <dbReference type="GeneID" id="2739428"/>
    <dbReference type="KEGG" id="tde:TDE_2333"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2202"/>
    <dbReference type="eggNOG" id="COG2949">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051474_0_1_12"/>
    <dbReference type="OMA" id="YDEPDAM"/>
    <dbReference type="OrthoDB" id="1879123at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="DUF218" evidence="2">
        <location>
            <begin position="51"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="226" mass="25996" checksum="DA1F12945B42A5E5" modified="2004-07-05" version="1">MKSKPIKKIALCIIFLFALILIGIVSINIYMLSYSKPYIYKNISALPEKYVVIVPGAKVYKNTVSHVVRDRIEAAVNCLKNKKAERVLISGDHGRKGYDEVNRMRIFMQDVYGTDENLIFMDHAGFSTYETMYRAREIFCIEDAVVVTQAFHTARAVYIGRKLGLDVIAYEAPEVLRYSRETRISWEIREALARVKTFFLVMFNVKPTFLGKKIPITGNAKDSWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KF4</accession>
    <name>Q73KF4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2264</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
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                <person name="Weinstock G.M."/>
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            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
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                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
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                <person name="Sodergren E."/>
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                <person name="Weinstock G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Tettelin H."/>
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                <person name="Davidsen T.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="80" mass="9350" checksum="743CD9C22835579B" modified="2004-07-05" version="1">MIVSLVPVGNSRGVRLPKLVLDKVSSADKFEVEVSEKGILLKPIKYEPRKGWEEAFRKMHQNNEDLAEDIPEPRDFQWEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KI5</accession>
    <name>Q73KI5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron compound ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972833.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680086.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2233"/>
    <dbReference type="EnsemblBacteria" id="AAS12752">
        <property type="protein sequence ID" value="AAS12752"/>
        <property type="gene ID" value="TDE_2233"/>
    </dbReference>
    <dbReference type="GeneID" id="2741338"/>
    <dbReference type="KEGG" id="tde:TDE_2233"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2109"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_3_12"/>
    <dbReference type="OMA" id="AWKRGVH"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="339" mass="35972" checksum="70B0A3BE30F0BBCD" modified="2004-07-05" version="1">MKLQFKLAGSIAACILVLILGIGIGSVFVPPQDIIKIIFSKIAQKEISCIEPTFVAIVWNVRLPRVLVAFLAGGSLAVSGAVMQSILKNPLASSYTMGVSSGAALGAALVILTGFTLPLIPAFTLPLAGTLAGLLTVYASVKVASLVDRNFENSTIILTGIVFSLFINGIITIIIALNRDGMARLIFWQMGSFASQNIKNFNVLLPICAAATLILTSLSHEMDLLTFGEEQAKTMGVDTKKVKWGLLFLASALTGTVISFVGIIGFIDLISPHIVRKLVGARHKIVVPVSFCIGGTAMVLCDMTARTILSPQELPVGAITALAGAPFFCYVYFKGRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KJ1</accession>
    <name>Q73KJ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972827.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680079.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2227"/>
    <dbReference type="EnsemblBacteria" id="AAS12746">
        <property type="protein sequence ID" value="AAS12746"/>
        <property type="gene ID" value="TDE_2227"/>
    </dbReference>
    <dbReference type="GeneID" id="2739503"/>
    <dbReference type="KEGG" id="tde:TDE_2227"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2103"/>
    <dbReference type="eggNOG" id="COG4330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081833_1_0_12"/>
    <dbReference type="OMA" id="WLLFLPN"/>
    <dbReference type="OrthoDB" id="1450712at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009793">
        <property type="entry name" value="DUF1361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07099">
        <property type="entry name" value="DUF1361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="219" mass="26110" checksum="83B308A6E49D30D0" modified="2004-07-05" version="1">MRHYFKNIFRIKSTFALMFLSFFCIFLSVCRIFIAENYFLLFLVWNLFLAFVPWLISSTLYLSKNNNKIIFIVFMTIWLLFFPNALYIVTDFIHLKTAASTMRWYDLILLFSYSFAGLFYGFVSLDFIEAKMQKLFNIKYPQIFSIFAIYLSAFGIYLGRFLRWNSWDLVTNLSSVLSDLFLPIKNPFIHARTWAFILLLGTLFNLLYISYKSFGEKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KK4</accession>
    <name>Q73KK4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972814.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668012.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2214"/>
    <dbReference type="EnsemblBacteria" id="AAS12733">
        <property type="protein sequence ID" value="AAS12733"/>
        <property type="gene ID" value="TDE_2214"/>
    </dbReference>
    <dbReference type="GeneID" id="2739490"/>
    <dbReference type="KEGG" id="tde:TDE_2214"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2091"/>
    <dbReference type="eggNOG" id="COG4226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134927_1_1_12"/>
    <dbReference type="OMA" id="MTYKGYA"/>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="111" mass="12628" checksum="E3FBD196B20A9143" modified="2004-07-05" version="1">MIEYKGYIGKIEYDPEAKILHGDVINTRDVITFQGTSVAEIEKAFIDSVDDYINWCREENIEPEKPYSGKFNIRISPELHKKIAINAKSLNLSLNTFVEKALQHELASTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KK7</accession>
    <name>Q73KK7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972811.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675657.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2211"/>
    <dbReference type="EnsemblBacteria" id="AAS12730">
        <property type="protein sequence ID" value="AAS12730"/>
        <property type="gene ID" value="TDE_2211"/>
    </dbReference>
    <dbReference type="GeneID" id="2739487"/>
    <dbReference type="KEGG" id="tde:TDE_2211"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2088"/>
    <dbReference type="eggNOG" id="ENOG5032NAV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1389684_0_0_12"/>
    <dbReference type="OrthoDB" id="1380617at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="199" mass="22049" checksum="208FD6C769D398C2" modified="2004-07-05" version="1">MKTNRKTRAAVLITAALIVLLFSGCAFLEGMAASPDRPSRSLSVGDRVGDKTIVWENTGAGSWKFLAMGTPSEPMPWDLDSSRHISIKNLSSGMGDGKENSIFLKREFESNGSKTHTVKNSAVMYCISRGGWLPSRDEAEKIAQFTSKDFWTSHCEASSKAYYYSPLQRGLQSKWRNDREPVVAIPVYYLDAQGNVTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KL2</accession>
    <name>Q73KL2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF126 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972806.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680049.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2206"/>
    <dbReference type="EnsemblBacteria" id="AAS12725">
        <property type="protein sequence ID" value="AAS12725"/>
        <property type="gene ID" value="TDE_2206"/>
    </dbReference>
    <dbReference type="GeneID" id="2739482"/>
    <dbReference type="KEGG" id="tde:TDE_2206"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2083"/>
    <dbReference type="eggNOG" id="COG1786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1701225_0_0_12"/>
    <dbReference type="OrthoDB" id="1578044at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01356">
        <property type="entry name" value="AcnX_swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012016">
        <property type="entry name" value="AcnX_sub2_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002840">
        <property type="entry name" value="AcnX_swivel_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01989">
        <property type="entry name" value="DUF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004966">
        <property type="entry name" value="UCP004966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF126" evidence="1">
        <location>
            <begin position="47"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="147" mass="15476" checksum="E28523F51CD2553B" modified="2004-07-05" version="1">MKTFKGRVIVPGTVSAEALVSSQGFNTLASFQKALMFGDKKAHCSDQNNLDLYKKEIAGKALCLPQTIGSTTGGMVIFCAASMGRQPACMLFSEPIDSLAAAGVILAANFTDNSIPTVDNLGKEFLAAVKSGSRVQVKENGEVIIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KL4</accession>
    <name>Q73KL4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na+/H+ antiporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_2204</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972804.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675647.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12723">
        <property type="protein sequence ID" value="AAS12723"/>
        <property type="gene ID" value="TDE_2204"/>
    </dbReference>
    <dbReference type="GeneID" id="2739480"/>
    <dbReference type="KEGG" id="tde:TDE_2204"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2081"/>
    <dbReference type="eggNOG" id="COG2056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037927_0_0_12"/>
    <dbReference type="OMA" id="MMAFIAF"/>
    <dbReference type="OrthoDB" id="1000841at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032813">
        <property type="entry name" value="Na_H_antiport_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13726">
        <property type="entry name" value="Na_H_antiport_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiport_2" evidence="8">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="142"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="433" mass="45810" checksum="FEEA082F7428632D" modified="2004-07-05" version="1">MFNPVVIAVIVMMVLCLLKINILIAIMISGIVGGIIGGLGLQNTISILISGMGGNAETALSYILLGTLAAAITSTSIVELLAVKLQKWLKNKKALFVLIIAFIGCFSQNAIPVHIAYIPILIPPLLVVMNKMKLDRRAMACGLTFSVKWPYVAFPAGFGLIFHGIISDSMTQNGLQFNKMDVWKAMALPGAGMILGLFIAVFFSYRKPREYKTVEADIKAENEVKNIKFTSREWFTLLAIAAAFVTQILSGSMPLGGLVGILVLLVTRVIKVKDADQTMAEGIKLMGFIAFVMLVAAGFAEVIKATKAVDALVVSSANLIGGSKLLGAIIMLLIGLGITMGIGTSFGTIPVIATIYVPLGMKLGFSPMAIACLLGTAGALGDAGSPASDSTLGPTAGLNADGQHDHIWDTCVPTFLHYNIPLMIFATIAAMFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KW3</accession>
    <name>Q73KW3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972705.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679910.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2104"/>
    <dbReference type="EnsemblBacteria" id="AAS12624">
        <property type="protein sequence ID" value="AAS12624"/>
        <property type="gene ID" value="TDE_2104"/>
    </dbReference>
    <dbReference type="GeneID" id="2740343"/>
    <dbReference type="KEGG" id="tde:TDE_2104"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1987"/>
    <dbReference type="eggNOG" id="ENOG5031BZG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007801_1_0_12"/>
    <dbReference type="OrthoDB" id="484965at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="852" mass="94676" checksum="FE9B95A683F729D6" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KZ8</accession>
    <name>Q73KZ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972670.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668289.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2069"/>
    <dbReference type="EnsemblBacteria" id="AAS12581">
        <property type="protein sequence ID" value="AAS12581"/>
        <property type="gene ID" value="TDE_2069"/>
    </dbReference>
    <dbReference type="GeneID" id="2741196"/>
    <dbReference type="KEGG" id="tde:TDE_2069"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1954"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_0_12"/>
    <dbReference type="OMA" id="GSYFKEP"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="125" mass="13262" checksum="009C28A9A014FE3F" modified="2004-07-05" version="1">MKEIIATNKAPSAIGPYSQGIKANGFVFTSGQIPLDPATGAFPEGIKAQTRQSLLNVKAILEQAGTSIDKVIKTTVFLSDMNNFAAMNEVYAEIFGSSNHPSRSAVQVARLPKDALVEIEVIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L06</accession>
    <name>Q73L06_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972662.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12573">
        <property type="protein sequence ID" value="AAS12573"/>
        <property type="gene ID" value="TDE_2060"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2060"/>
    <dbReference type="eggNOG" id="ENOG5031DVM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2588677_0_0_12"/>
    <dbReference type="OrthoDB" id="2185502at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="80" mass="9157" checksum="D0B7A80E1E6526B3" modified="2004-07-05" version="1">MLPIHRCIMINKLNYSSGGCAGFSPVSLLILKINLRTLFVYNLRVIINISKKKASPQRDTNGDLLSIYYPTYFQPYPKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L08</accession>
    <name>Q73L08_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972660.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679851.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2058"/>
    <dbReference type="EnsemblBacteria" id="AAS12571">
        <property type="protein sequence ID" value="AAS12571"/>
        <property type="gene ID" value="TDE_2058"/>
    </dbReference>
    <dbReference type="GeneID" id="2740652"/>
    <dbReference type="KEGG" id="tde:TDE_2058"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1943"/>
    <dbReference type="eggNOG" id="COG5266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058596_0_0_12"/>
    <dbReference type="OMA" id="PFGNYAG"/>
    <dbReference type="OrthoDB" id="1382281at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019613">
        <property type="entry name" value="DUF4198"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10670">
        <property type="entry name" value="DUF4198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285943" evidence="1">
        <location>
            <begin position="21"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="272" mass="30090" checksum="4D9A6CDE9CD9D913" modified="2004-07-05" version="1">MKKRTGIVLFLFLVSMASFAHFQMIYTPTSRVEGNSVDFKIVFTHPAESGHAMDVGKNEAGEIKGFEKFFSVHKAKIQDLLPSLKKTEFTTSENTASAYDLTLNKDNGFRGGGDWALIAVPHPYYEGAEDKYIQQITKVFINKAGLDTDWSARCAEGYPEIMPLVKPYDVWVGGLFRGTVVDSKGKPVPNAEIEVEYINFDVNMKKSKFEKKAKTKNAAAVILADENGNFSFVPHKAGYWGFAALGAGNVKEFAGKELSQDAVLWIEAVPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L15</accession>
    <name>Q73L15_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972653.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679831.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2051"/>
    <dbReference type="EnsemblBacteria" id="AAS12564">
        <property type="protein sequence ID" value="AAS12564"/>
        <property type="gene ID" value="TDE_2051"/>
    </dbReference>
    <dbReference type="GeneID" id="2740645"/>
    <dbReference type="KEGG" id="tde:TDE_2051"/>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149290_1_1_12"/>
    <dbReference type="OMA" id="MYIQLGM"/>
    <dbReference type="OrthoDB" id="2065431at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="102" mass="12077" checksum="45E49D04F5378BA3" modified="2004-07-05" version="1">MENGNTTQRLFEWDYEKEQRNMKIHKISFETARLVFNDNNRIELFDINHSGAEDRIITIGKVDKVLFVVYTERGEKTRIISARAATKAERRLYGNSYIGFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L34</accession>
    <name>Q73L34_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972634.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12545">
        <property type="protein sequence ID" value="AAS12545"/>
        <property type="gene ID" value="TDE_2031"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2031"/>
    <dbReference type="HOGENOM" id="CLU_3405979_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3697" checksum="A4A5B54E514381F7" modified="2004-07-05" version="1">MILNKKPKLPLWKLGKNYFRRFYVLPTFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LA7</accession>
    <name>Q73LA7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972561.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957111.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1958"/>
    <dbReference type="EnsemblBacteria" id="AAS12472">
        <property type="protein sequence ID" value="AAS12472"/>
        <property type="gene ID" value="TDE_1958"/>
    </dbReference>
    <dbReference type="GeneID" id="2741521"/>
    <dbReference type="KEGG" id="tde:TDE_1958"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1850"/>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035234_0_0_12"/>
    <dbReference type="OMA" id="KEAFFAC"/>
    <dbReference type="OrthoDB" id="956253at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="458" mass="49662" checksum="F664E4576D974B68" modified="2004-07-05" version="1">MKQIKTLLTAEEKVNLQLLEITDGMLTRVTDSNKLIGSLVLPDSVVEIGMGAFYCCTGLTSVKIPDSVHKIDKWSFFSCTALTSVAISKSVTEIGSMVFTGCINLTKLTVDSANPVYCTENNIIYTKDKKKLIAAASGLEHIVIPDSVTDIGGPFYDCTRLANLTVGSENTVYYSENNIIYTKDKKKLIAAASGLESVVIPEGVTEIGEHAFSACSVLTDVVIPNTVTDIAKSAFYGCTRLTKLIVDIENPVYCSENNIIYTKDKKKLIAVAGGLEHIVIPDTVSDIGGWGFFDCTRLTHLSVDSENPVYCSEGNIIYTKDKKKLIAAASCLRSVVIADGVTEIPSWGFSACSNLTDVVIPDTVTEIGDMAFFDCSFLTNVIIPNNVTTIGDHAFSYCSKLKTVIIDSAVVTDIEDNAFENVHADVHFTVKTDKVKALLKKSDSSIRDEQITVVQVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LB3</accession>
    <name>Q73LB3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972555.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679669.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1952"/>
    <dbReference type="EnsemblBacteria" id="AAS12466">
        <property type="protein sequence ID" value="AAS12466"/>
        <property type="gene ID" value="TDE_1952"/>
    </dbReference>
    <dbReference type="GeneID" id="2740192"/>
    <dbReference type="KEGG" id="tde:TDE_1952"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1844"/>
    <dbReference type="eggNOG" id="ENOG5030RM3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103694_0_0_12"/>
    <dbReference type="OrthoDB" id="1997703at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026002">
        <property type="entry name" value="ATC_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14196">
        <property type="entry name" value="ATC_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="216" mass="24953" checksum="B3455BD40DD7B133" modified="2004-07-05" version="1">MKMTSEKIFEIPQMSADWIRNELNKKFQPDEAEKKYREVIETYEKFANDAPSIGGKDNPMSKNFYGALSAFAYYECMNRSMLPDEITAMCYGMMIGNKKGGQLSRFNLNNRLVQKLFHGLFGLRARKLNKHKEDGSWNNTWGMKINPLHHKEGISIHLIGCPIADFAKKNGYGELMPYFCETDKAVMEHFGGTLYREHTVADGYEDCDYWIKNKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LE1</accession>
    <name>Q73LE1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12438.1"/>
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    </dbReference>
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        <property type="gene ID" value="TDE_1924"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000008212">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="70" mass="8312" checksum="0754B151BF9A13A3" modified="2004-07-05" version="1">MVNLITGTDCGGINSSKFFIIYYFFQIITINIMRRGKCEKIRRTQMVKRFEDLTFTRRLIKNVPPCTFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LG2</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ordered locus">TDE_1902</name>
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    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="32" mass="3810" checksum="551BCCE1F763F254" modified="2004-07-05" version="1">MSHKNSPIKNFCNKYQFAKKVFSRSLFTNCIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LJ3</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ordered locus">TDE_1869</name>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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        <property type="protein sequence ID" value="AAS12384.1"/>
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        <property type="gene ID" value="TDE_1869"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="40" mass="4814" checksum="8394B6556A7EB1A9" modified="2004-07-05" version="1">MYKNDEITVIQNEKTTCIITDTNLIDFFTRNDEHYNLSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LM4</accession>
    <name>Q73LM4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
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    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1838"/>
    <dbReference type="EnsemblBacteria" id="AAS12353">
        <property type="protein sequence ID" value="AAS12353"/>
        <property type="gene ID" value="TDE_1838"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.1744"/>
    <dbReference type="eggNOG" id="COG1724">
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    </dbReference>
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    <dbReference type="OMA" id="MDSRTLI"/>
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    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="65" mass="7168" checksum="5F2C57A3E8F94368" modified="2004-07-05" version="1">MIGYKMTAKEIEKILKADGWYFVTAKGSHNQYKHTVKSGKVTVPNHKGDIPIGTVKAILKQAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LP3</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ordered locus">TDE_1819</name>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972423.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1819"/>
    <dbReference type="EnsemblBacteria" id="AAS12334">
        <property type="protein sequence ID" value="AAS12334"/>
        <property type="gene ID" value="TDE_1819"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1819"/>
    <dbReference type="HOGENOM" id="CLU_3334246_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="38" mass="4650" checksum="7BE8EAC07CF9190E" modified="2004-07-05" version="1">MEIDIADFISGYKSEQFVSNYDDWNYKDVISHLFEWIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LX7</accession>
    <name>Q73LX7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972339.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1735"/>
    <dbReference type="EnsemblBacteria" id="AAS12250">
        <property type="protein sequence ID" value="AAS12250"/>
        <property type="gene ID" value="TDE_1735"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1735"/>
    <dbReference type="HOGENOM" id="CLU_3334244_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="38" mass="4612" checksum="FDF7C94E62676D71" modified="2004-07-05" version="1">MAKVPISFFLHRFYIAFFICKCYNKDIEIYDKEYANGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LY9</accession>
    <name>Q73LY9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972327.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679442.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1723"/>
    <dbReference type="EnsemblBacteria" id="AAS12238">
        <property type="protein sequence ID" value="AAS12238"/>
        <property type="gene ID" value="TDE_1723"/>
    </dbReference>
    <dbReference type="GeneID" id="2739181"/>
    <dbReference type="KEGG" id="tde:TDE_1723"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1647"/>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_747723_0_0_12"/>
    <dbReference type="OMA" id="GWQASMN"/>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038901">
        <property type="entry name" value="HEXDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21040">
        <property type="entry name" value="PTHR21040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285971" description="Beta-N-acetylhexosaminidase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_20" evidence="6">
        <location>
            <begin position="44"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="354" mass="40483" checksum="4DE1EA3F2B3E09D9" modified="2004-07-05" version="1">MTTKTLKEKAMVLVPFLLLLLLQPAVYAQTNGTMPKRKFVIAFHASVNTDKTGKNLIKELPDLQKRGINTLFLEIGYNYQWKSDPKLYNKYVLSETVAREIAAECRRLSIDLIPEINCLGHQSWENETFALLKAYPELDETPGLYPSNKDIYCRSLCSSNEKVYTILFGLIDEITEVFSVKKIHVGLDEVFLIGEDACPLCRGKDKAELFAGAVNRLYDHCVKKRGFTMYMWGDRLIDSEDEDSGYKGEYESSCNGTYPAVDLIPKDIIICDWHYDELERYGSIPYFLNKGFRVLPTSFKGIKAVNALIDYSLLYKDNPAMLGHMYTAWDNFTNKNLSRYKPMVKTIDKLKAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LZ3</accession>
    <name>Q73LZ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972323.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679434.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1719"/>
    <dbReference type="EnsemblBacteria" id="AAS12234">
        <property type="protein sequence ID" value="AAS12234"/>
        <property type="gene ID" value="TDE_1719"/>
    </dbReference>
    <dbReference type="GeneID" id="2739177"/>
    <dbReference type="KEGG" id="tde:TDE_1719"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_3_12"/>
    <dbReference type="OMA" id="GLTPFHW"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031011">
        <property type="entry name" value="Reg_MarR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04472">
        <property type="entry name" value="reg_rSAM_mob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="145" mass="16704" checksum="51ABDFE8B03530E3" modified="2004-07-05" version="1">MEMNGGFLVTKIKQLGDRIFEKILSEKNIDAFNGAQGRILYVLWQEDGIPIGSLSIKCGLAITSLTTMLERMENQGLISRVQSETDKRKILLFLTEKAHALKDEYNSVSDEMGSIYYKGFSEEEITRFEECLDRIRKNLEEWQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M19</accession>
    <name>Q73M19_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972296.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12207">
        <property type="protein sequence ID" value="AAS12207"/>
        <property type="gene ID" value="TDE_1692"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1692"/>
    <dbReference type="HOGENOM" id="CLU_3391911_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="32" mass="3799" checksum="D30928B831664033" modified="2004-07-05" version="1">MKLIAKILKRIKFYSCGGKGYPLPFQYRLNNH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M71</accession>
    <name>COAE_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name type="ordered locus">TDE_1638</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972244.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679322.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M71"/>
    <dbReference type="SMR" id="Q73M71"/>
    <dbReference type="STRING" id="243275.TDE_1638"/>
    <dbReference type="EnsemblBacteria" id="AAS12155">
        <property type="protein sequence ID" value="AAS12155"/>
        <property type="gene ID" value="TDE_1638"/>
    </dbReference>
    <dbReference type="GeneID" id="2739747"/>
    <dbReference type="KEGG" id="tde:TDE_1638"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1566"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057180_2_2_12"/>
    <dbReference type="OMA" id="DVDKEYH"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000173025" description="Dephospho-CoA kinase">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="DPCK" evidence="1">
        <location>
            <begin position="22"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <sequence length="223" mass="25840" checksum="65B061519113D9E5" modified="2004-07-05" version="1">MDSVLNGRQSRQSLDAPSEPILIGLSGPSCSGKNTASTILQDYGFYCIDADAVSRKVFTEHEKEILNLFQAEAEKRGINLKNENGIDKKAFALLVFSDEELLKKHEAFILPIIEEKIWEEIKRAFTEKPERPILLNAPTLHKTSFIKKCLFILYIDAPFILRLIRAKKRDRLPLKNIWLRFSKQKKFFSQYFFLNADTIVVKNFWSSASLKRKLLQEVKKRGF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MC7</accession>
    <name>GLGA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycogen synthase</fullName>
            <ecNumber evidence="1">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Starch [bacterial glycogen] synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgA</name>
        <name type="ordered locus">TDE_1582</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972188.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679256.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MC7"/>
    <dbReference type="SMR" id="Q73MC7"/>
    <dbReference type="STRING" id="243275.TDE_1582"/>
    <dbReference type="CAZy" id="GT5">
        <property type="family name" value="Glycosyltransferase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12099">
        <property type="protein sequence ID" value="AAS12099"/>
        <property type="gene ID" value="TDE_1582"/>
    </dbReference>
    <dbReference type="GeneID" id="2739779"/>
    <dbReference type="KEGG" id="tde:TDE_1582"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1512"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_18_5_12"/>
    <dbReference type="OMA" id="TWCPWYM"/>
    <dbReference type="OrthoDB" id="83240at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000188659" description="Glycogen synthase">
        <location>
            <begin position="1"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <sequence length="491" mass="55970" checksum="F1E6A19779BFADAE" modified="2004-07-05" version="1">MKIMMVTSELVPFAKVGGLADAVTALSIALAEKRHDVRVVMPRYYKIDRKNLKQIPGAMAVHLGPYEHWVGVYESNLPSSKVKVYFIDHEQAFGRDGVYGSAFEPDFSDNTKRFSLLAHAAFQVCRKQAWIPDVVHAHDWAAGLVPVLLRFTEKNTEFKNTASVFTIHNMGYQGVYSKHTFPDTGLDWNDFYTTGFEDWDRINFLKAALVSSDMLTTVSPSYAEEIKRPEFGFRMDGILRYREKELTGILNGVDTSIWNPSKDEYIPYRYNSKTLEEKEKNKSVLQERFGLEIDISVPVFGMISRLVDQKGISELFGPMYGSAFKICSDIKLQMVVLGSGESWCEKELNFLSQRLPNFRCYIGYNEELSHLIEAGSDFFLMPSRYEPCGLNQMYSLLYGTLPIVRKTGGLADTVENYNEETGEGTGFVLDYLSPQSIYDTVGWAAYAWYNKKDHIKKMRTKAMSKKFGWNIAAEKYLKVYADAIEKKASML</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MK5</accession>
    <name>Q73MK5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">rho</name>
        <name evidence="12" type="ordered locus">TDE_1503</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972109.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668994.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1503"/>
    <dbReference type="EnsemblBacteria" id="AAS12020">
        <property type="protein sequence ID" value="AAS12020"/>
        <property type="gene ID" value="TDE_1503"/>
    </dbReference>
    <dbReference type="GeneID" id="2739904"/>
    <dbReference type="KEGG" id="tde:TDE_1503"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1442"/>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016377_2_1_12"/>
    <dbReference type="OMA" id="TRLCRAH"/>
    <dbReference type="OrthoDB" id="1619125at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="175"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="293"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="305"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS12020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="548" mass="61856" checksum="30B48A7A05B88876" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ML3</accession>
    <name>Q73ML3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972101.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671240.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1495"/>
    <dbReference type="EnsemblBacteria" id="AAS12012">
        <property type="protein sequence ID" value="AAS12012"/>
        <property type="gene ID" value="TDE_1495"/>
    </dbReference>
    <dbReference type="GeneID" id="2739896"/>
    <dbReference type="KEGG" id="tde:TDE_1495"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1434"/>
    <dbReference type="eggNOG" id="ENOG5032MGY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1348429_0_0_12"/>
    <dbReference type="OrthoDB" id="1849948at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="206" mass="23953" checksum="4F0691BCB27FEC54" modified="2004-07-05" version="1">MKVLVFDRKIETLAFLCEKLENHGIITIAAENGSKFICNYLDPELDAIIVATKELAHYSLNEARLIKKIYKDITICTYFHEDCYNIKNINIVSSSGIPENIRGNEKILKIILSKCKRRPDLNKDYIYSLPKKSGILLKHLIINRQKGLSDEEISTIFWGEKIPSKQNSIYNHVYNLKKSLKKSFSNRYTILKANKRYRLIKLKKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MM7</accession>
    <name>Q73MM7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972087.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679144.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1481"/>
    <dbReference type="EnsemblBacteria" id="AAS11998">
        <property type="protein sequence ID" value="AAS11998"/>
        <property type="gene ID" value="TDE_1481"/>
    </dbReference>
    <dbReference type="GeneID" id="2739882"/>
    <dbReference type="KEGG" id="tde:TDE_1481"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1420"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053649_0_0_12"/>
    <dbReference type="OMA" id="AWEKNWG"/>
    <dbReference type="OrthoDB" id="884913at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039968">
        <property type="entry name" value="YghO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41368">
        <property type="entry name" value="PTHR41368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="378" mass="44368" checksum="8A9ED3B350592AC6" modified="2004-07-05" version="1">MDKISLFEVNNSKLLNEFALLPFELYKNDSSWVPPIISEYKKYVSGADNSLCDVGPHVKMVAKIEGKTVGRILYGIDEKLNDYKKMKVGYISQFECIEDYAVAEKMLNAAKEWFLQKGMDRIKGPLSLPGGEDNRGFITDNFETRTYIMNTYNKKYYNDFFIKYGFEKYWDCYAYHARFDDVDASRYVRLAPLVEKRYGFHVDTIDLKNNVEREAGDIHSILLNSEPEEWEDFMPMTRKEIDMVVKQLISFADEELIFIARSNEGKPIGFNVTLPDYNDVLKHLKGKLFPFGIFKFLYYKRKMKRLRTFVLFVDPQYHNKGVSAAIYSRLYQAAIKKGYLEGEGSTIWEYNIPMITDIEKTGAKRDIVYRIYQYHLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MN6</accession>
    <name>Q73MN6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar hook-associated protein 2</fullName>
            <shortName evidence="5">HAP2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Flagellar cap protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fliD</name>
        <name evidence="8" type="ordered locus">TDE_1472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Periplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Periplasmic flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FliD family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972078.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679139.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1472"/>
    <dbReference type="EnsemblBacteria" id="AAS11989">
        <property type="protein sequence ID" value="AAS11989"/>
        <property type="gene ID" value="TDE_1472"/>
    </dbReference>
    <dbReference type="GeneID" id="2741587"/>
    <dbReference type="KEGG" id="tde:TDE_1472"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1413"/>
    <dbReference type="eggNOG" id="COG0373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028399_0_0_12"/>
    <dbReference type="OMA" id="FIGAYNE"/>
    <dbReference type="OrthoDB" id="883503at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009421">
        <property type="term" value="C:bacterial-type flagellum filament cap"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040026">
        <property type="entry name" value="FliD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010809">
        <property type="entry name" value="FliD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003481">
        <property type="entry name" value="FliD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30288">
        <property type="entry name" value="PTHR30288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07195">
        <property type="entry name" value="FliD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02465">
        <property type="entry name" value="FliD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliD_N" evidence="6">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="FliD_C" evidence="7">
        <location>
            <begin position="378"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="591"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="652" mass="73303" checksum="935BF20329893B73" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MN8</accession>
    <name>Q73MN8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972076.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668946.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1470"/>
    <dbReference type="EnsemblBacteria" id="AAS11987">
        <property type="protein sequence ID" value="AAS11987"/>
        <property type="gene ID" value="TDE_1470"/>
    </dbReference>
    <dbReference type="GeneID" id="2741585"/>
    <dbReference type="KEGG" id="tde:TDE_1470"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1411"/>
    <dbReference type="eggNOG" id="ENOG5031EHQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_170137_1_0_12"/>
    <dbReference type="OMA" id="HIYYRRV"/>
    <dbReference type="OrthoDB" id="1991781at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="86" mass="10173" checksum="258BB2C39E42B452" modified="2004-07-05" version="1">MIVSEIKDIEKEDTHIYYRQKYVGTAIYTILGREQNGKVEFFVEHKPTGETEIQVQMIDKIDYPVLQIMMELKACVRRLIEARKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MQ1</accession>
    <name>Q73MQ1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MAF_flag10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972063.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679114.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1457"/>
    <dbReference type="EnsemblBacteria" id="AAS11974">
        <property type="protein sequence ID" value="AAS11974"/>
        <property type="gene ID" value="TDE_1457"/>
    </dbReference>
    <dbReference type="GeneID" id="2741572"/>
    <dbReference type="KEGG" id="tde:TDE_1457"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1398"/>
    <dbReference type="eggNOG" id="COG2604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034548_0_0_12"/>
    <dbReference type="OMA" id="SIDCQHI"/>
    <dbReference type="OrthoDB" id="912403at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAF_flag10" evidence="1">
        <location>
            <begin position="198"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="507" mass="57365" checksum="B42D4113F20BCB20" modified="2004-07-05" version="1">MNFFDKNIEALKKINLKLAEDIINSDDNSDYSSDKDVSKTGFDLPLLKNGKLLHSKYDPLKEASRLFTGNENFILFCGLGAGIHIEFFLNNFKSKYCAVTEASFSNFKSLFKIIDFSHLILNKNLSFLPPLESENFEKEFINSYIPAIHGNFEIKILRPWEDFYNEKIQTFEKKIQASLEKIQADVSTQAAFGKIWMRNIMQNLKTASLIRPFIPKTDPSKKAYILGAGPSLESALENIKKYRDSIVLFASDTAFPVLISAGIEADFFVTMDPQNISYAHCFKPFTKSTVGIFDLCSNPILAREFLKNGNSFFFTKSAHPFAQYASFFSPFPYMETGSGTVALAARSAALSLGFKDLEFFGLDFAYTGGKAYAAGTYLSKQFEKTSSKTSPLETKFCDLMFRTEVKKTQENGKITYTTALLDGYKAFFKGVISLNSASPVWKKEDFSIFQYEEFIRHLKTPACKDKKMLTTALLPYFAYLNKRLSKNISNFADVELVLSQILEYTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MV7</accession>
    <name>Q73MV7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="3">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972006.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678987.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1400"/>
    <dbReference type="EnsemblBacteria" id="AAS11917">
        <property type="protein sequence ID" value="AAS11917"/>
        <property type="gene ID" value="TDE_1400"/>
    </dbReference>
    <dbReference type="GeneID" id="2741267"/>
    <dbReference type="KEGG" id="tde:TDE_1400"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1342"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025662_0_0_12"/>
    <dbReference type="OMA" id="VLMPSPY"/>
    <dbReference type="OrthoDB" id="1152435at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041856">
        <property type="entry name" value="NAD+_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="5">
        <location>
            <begin position="337"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="650" mass="72388" checksum="EE7900BA578911D2" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MY1</accession>
    <name>COAD_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="1">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaD</name>
        <name type="ordered locus">TDE_1375</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971981.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678956.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MY1"/>
    <dbReference type="SMR" id="Q73MY1"/>
    <dbReference type="STRING" id="243275.TDE_1375"/>
    <dbReference type="EnsemblBacteria" id="AAS11892">
        <property type="protein sequence ID" value="AAS11892"/>
        <property type="gene ID" value="TDE_1375"/>
    </dbReference>
    <dbReference type="GeneID" id="2741136"/>
    <dbReference type="KEGG" id="tde:TDE_1375"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1320"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100149_0_1_12"/>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="OrthoDB" id="1846503at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000156299" description="Phosphopantetheine adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <sequence length="160" mass="18162" checksum="8A8807B4418BCFCA" modified="2004-07-05" version="1">MVKAVFAGSFDPPTFGHLNVIERAQKIFTEVHVVIAVNNNKNYLFSGEERKHMMEELTQKWDNVFVNTWNSLIVNYAEKIGANVLIRGVRNVSDFSYEFDLAVMNKGLNQKIETVFMVPDTKYFVLRSSSIKELASFGGNLSGMVPPIVEKALKEKIEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MZ0</accession>
    <name>Q73MZ0_TREDE</name>
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        <submittedName>
            <fullName evidence="3">CDP-alcohol phosphatidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
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        <property type="protein sequence ID" value="AAS11883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971972.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671441.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1366"/>
    <dbReference type="EnsemblBacteria" id="AAS11883">
        <property type="protein sequence ID" value="AAS11883"/>
        <property type="gene ID" value="TDE_1366"/>
    </dbReference>
    <dbReference type="GeneID" id="2739467"/>
    <dbReference type="KEGG" id="tde:TDE_1366"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1312"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110585_1_0_12"/>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="193" mass="22721" checksum="208E0E5E38C89DA3" modified="2004-07-05" version="1">MIYNKTFDIQKKIFINTLTLLRIPLSIMFNVMLLYEERRLFLYGILFLVIALTDFFDGKLARYYNVQSRVGAVLDVTTDFFFIFTTACVMYKQGLLPVGMIIIILIKFTEFCITSYLFDKKLKKNKLLFFDKIGRFVAVILYSIPIIILILHALLNKYLFNVILFCVYITIGFLSILSFYARVSKIIRYKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MZ7</accession>
    <name>Q73MZ7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971965.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678921.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11876">
        <property type="protein sequence ID" value="AAS11876"/>
        <property type="gene ID" value="TDE_1359"/>
    </dbReference>
    <dbReference type="GeneID" id="2739460"/>
    <dbReference type="KEGG" id="tde:TDE_1359"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1306"/>
    <dbReference type="HOGENOM" id="CLU_604006_0_0_12"/>
    <dbReference type="OrthoDB" id="1740217at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="455" mass="52100" checksum="4DFA32E6DFD05B89" modified="2004-07-05" version="1">MMLLCSIFLNAEIPVEKANFSLTQSIDLNFNYNLKAEAKNPFFELYTEAKMREYRPKFALMPQGFSLKFSPLLYREKKQLYPALSFFYGGITKSSFLNLMLLKESFEKKPFYKGIGFAPKYLIGISKSKFDASLGTEFAIKNFNLVFFSEQKPKELWPDLSFCTVYKKENETALFNMSFFSSLTNSAYSQFNLKAPAYDQFYSGEFILAEKGTVSSVFLLAGGIKIPYGKISGIGESDLNFLGKAEYNFQSEYFEANAGTMFENDGTLKAFFQPKISVDALDLGFSYNFLRKYFEKKKLFKNFHSGGMGLGLSFTKCKFSGEIYYNDSSWDLKGQIKIPINLFFNTLFSIKGNTKLEEKSQNPFIVKNYSFSSDIKIKFNKSFNLNISASFMQKNKTVKINKSPYIVWEKGVFNFSTQAEFIKKTRLTSNSFKGEIILETAKPFIKGSLAYKISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N36</accession>
    <name>Q73N36_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ComEC/Rec2-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971926.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956948.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1320"/>
    <dbReference type="EnsemblBacteria" id="AAS11837">
        <property type="protein sequence ID" value="AAS11837"/>
        <property type="gene ID" value="TDE_1320"/>
    </dbReference>
    <dbReference type="GeneID" id="2739578"/>
    <dbReference type="KEGG" id="tde:TDE_1320"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1269"/>
    <dbReference type="eggNOG" id="COG0658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036608_0_0_12"/>
    <dbReference type="OMA" id="KVITIRQ"/>
    <dbReference type="OrthoDB" id="1682001at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="7">
        <location>
            <begin position="252"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="524" mass="57270" checksum="46B394FFFC2F6884" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N46</accession>
    <name>Q73N46_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Modulator of DNA gyrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971916.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678843.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1310"/>
    <dbReference type="EnsemblBacteria" id="AAS11827">
        <property type="protein sequence ID" value="AAS11827"/>
        <property type="gene ID" value="TDE_1310"/>
    </dbReference>
    <dbReference type="GeneID" id="2739568"/>
    <dbReference type="KEGG" id="tde:TDE_1310"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1259"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_646900_0_0_12"/>
    <dbReference type="OMA" id="FEIVTDC"/>
    <dbReference type="OrthoDB" id="667641at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_M" evidence="2">
        <location>
            <begin position="122"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="1">
        <location>
            <begin position="228"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="432" mass="48658" checksum="F4CCA30BCFB2985B" modified="2004-07-05" version="1">MKDKIISILKNKKNIDGYRLVLTKIRSGEMFLVRDKMDMNRAKNVLHTSLTVYKDFEEAGKKYRGSADASLSPTMDEEEINKKIEEAAFAAQFVKNEWYPLSRPSSEKPFSLSSSFDTENLNEELVKIQKAIYKKRDTKAEINSTEIFIDNMEVQIVNSEGVDVRFKKYKGYIEVITDCSIGKEEVEIYGDNSFSTESEKLIDNMVSEQLKETEERALAEKAKHLKSVNVIITNTAAASFFDFYISQASASMVYTKSSAAKLGENFQGSGVKGDKVNIKLVPNMAGSPYSAPYDGDGLLLKEHELYKDGIVKTYHGSIKFAHYLNVEPTGNIINFEVGAGAKTEADLKKEPYVEILTFSDFFQDEVTGDFGGEFRLARYFDGKALHIINNGSISGNMFDAQKEFYFSKERVQHSNYLGPKSIMIPNMEVLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N48</accession>
    <name>Q73N48_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transketolase</fullName>
            <ecNumber evidence="3 8">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tkt</name>
        <name evidence="10" type="ordered locus">TDE_1308</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971914.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678841.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1308"/>
    <dbReference type="EnsemblBacteria" id="AAS11825">
        <property type="protein sequence ID" value="AAS11825"/>
        <property type="gene ID" value="TDE_1308"/>
    </dbReference>
    <dbReference type="GeneID" id="2739566"/>
    <dbReference type="KEGG" id="tde:TDE_1308"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1257"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_12"/>
    <dbReference type="OMA" id="HHTEGIE"/>
    <dbReference type="OrthoDB" id="188169at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="9">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="675" mass="73240" checksum="1D4DD0C150D82B41" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N58</accession>
    <name>Q73N58_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971904.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668609.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1298"/>
    <dbReference type="EnsemblBacteria" id="AAS11815">
        <property type="protein sequence ID" value="AAS11815"/>
        <property type="gene ID" value="TDE_1298"/>
    </dbReference>
    <dbReference type="GeneID" id="2741052"/>
    <dbReference type="KEGG" id="tde:TDE_1298"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1248"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1517268_0_0_12"/>
    <dbReference type="OMA" id="RERETMV"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="177" mass="19909" checksum="0A3D683DF31F882E" modified="2004-07-05" version="1">MNKVEMDRDIFFQEVKQTAFFSCMEDADLMQIIDFSEILSYERGESIITEGTENNGFFVLLSGKLEIVKSGKWGDVKIGILQNNASFGETSLFKDQPATATVNALDPSTILLISKEQFTAYINAHPKAGNVILTYIVFSLLQKLNTTNKERVQEKNLEFSPEDLAFMVDMFTPPTEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-07" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N77</accession>
    <name>Y1278_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0340 protein TDE_1278</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_1278</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0340 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971885.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678780.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73N77"/>
    <dbReference type="SMR" id="Q73N77"/>
    <dbReference type="STRING" id="243275.TDE_1278"/>
    <dbReference type="EnsemblBacteria" id="AAS11796">
        <property type="protein sequence ID" value="AAS11796"/>
        <property type="gene ID" value="TDE_1278"/>
    </dbReference>
    <dbReference type="GeneID" id="2740571"/>
    <dbReference type="KEGG" id="tde:TDE_1278"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1228"/>
    <dbReference type="eggNOG" id="COG4475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106658_0_0_12"/>
    <dbReference type="OMA" id="FIGMHLR"/>
    <dbReference type="OrthoDB" id="1634553at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00800">
        <property type="entry name" value="UPF0340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028345">
        <property type="entry name" value="Antibiotic_NAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006340">
        <property type="entry name" value="DUF436"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04260">
        <property type="entry name" value="DUF436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007510">
        <property type="entry name" value="UCP007510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110710">
        <property type="entry name" value="SSF110710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01440">
        <property type="entry name" value="TIGR01440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000213033" description="UPF0340 protein TDE_1278">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00800"/>
        </source>
    </evidence>
    <sequence length="186" mass="19763" checksum="07355EBAB3EA2B0B" modified="2004-07-05" version="1">MSGIDLEKIKEETIAALNELLEAASLKAGDILVLGCSTSEVSGGVIGKASNEEAGRTIVSALLSVLEPKGIFLAVQGCEHINRALVIEKESQEKYGFEEVSVVPALHAGGAASLAAYNLFKSPVMIEHVRAHAGIDIGDTEIGMHVKFVQVPVRLKTKYIGSARLTALKSRPKLIGGERAVYEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N85</accession>
    <name>Q73N85_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971877.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678773.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1270"/>
    <dbReference type="EnsemblBacteria" id="AAS11788">
        <property type="protein sequence ID" value="AAS11788"/>
        <property type="gene ID" value="TDE_1270"/>
    </dbReference>
    <dbReference type="GeneID" id="2740563"/>
    <dbReference type="KEGG" id="tde:TDE_1270"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1221"/>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100275_2_0_12"/>
    <dbReference type="OrthoDB" id="1430018at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="144" mass="16265" checksum="82AD71E9D5C42D3F" modified="2004-07-05" version="1">MSTFRAKVRREEKFRMKCESGNHTMLLDEPLKAGGTDLAMNPVEALLSSLGACKCINAWIFADQFGINLKDIVFEMEGDIGALEKVDNCLPLIFKSIHTKITVFSDNTEEEIKKFIEYIELRCPVRNTIINQVPCTSEIIIGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NA8</accession>
    <name>Q73NA8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4469 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971854.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678739.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1247"/>
    <dbReference type="EnsemblBacteria" id="AAS11765">
        <property type="protein sequence ID" value="AAS11765"/>
        <property type="gene ID" value="TDE_1247"/>
    </dbReference>
    <dbReference type="GeneID" id="2741423"/>
    <dbReference type="KEGG" id="tde:TDE_1247"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1199"/>
    <dbReference type="eggNOG" id="ENOG503295Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092785_0_0_12"/>
    <dbReference type="OMA" id="GPYITEV"/>
    <dbReference type="OrthoDB" id="1207078at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd12843">
        <property type="entry name" value="Bvu_2165_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027824">
        <property type="entry name" value="DUF4469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14734">
        <property type="entry name" value="DUF4469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4469" evidence="1">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="240" mass="25375" checksum="55CC08FBF9F5EB89" modified="2004-07-05" version="1">MLKYCLRENLLTPAPDDYMAQAADVRSYTLDEIIGLMMQKGSTLTRADVAATLQVYGEVCAALIADGSAVNTPLMNTSLSISGVFNGAADTFDKKRHTVNLNMSAGTLLRDAVSKIKCEKTESTSTGPYITEVTDIVSGKVNEVLTKGGIIQLTGSRLKFDAKDSKQGIFFVPETGAPESAAVSASVIAENKPARLMAVIPADLAAGTYYIEVRTKLSGGGTKLKTVKKGTFGKPLTVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NC3</accession>
    <name>Q73NC3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971839.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1232"/>
    <dbReference type="EnsemblBacteria" id="AAS11750">
        <property type="protein sequence ID" value="AAS11750"/>
        <property type="gene ID" value="TDE_1232"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1232"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1187"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_1_3_12"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="270"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="559" mass="61553" checksum="495057CCE31205F2" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NC6</accession>
    <name>Q73NC6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971836.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678723.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1229"/>
    <dbReference type="DNASU" id="2741171"/>
    <dbReference type="EnsemblBacteria" id="AAS11747">
        <property type="protein sequence ID" value="AAS11747"/>
        <property type="gene ID" value="TDE_1229"/>
    </dbReference>
    <dbReference type="GeneID" id="2741171"/>
    <dbReference type="KEGG" id="tde:TDE_1229"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1184"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_4_12"/>
    <dbReference type="OMA" id="FCNTYLV"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="195" mass="22252" checksum="2B3B1E57F256B3B5" modified="2004-07-05" version="1">MKVYLHFSPQFFANTYLIGNEITKEAVIIDPAKITEKMIHQIEKNEFNLKAVLLTHDLEHPYETGLNTILKIYSPKVYAGSCFSENVTINTLRGDGCIDVAGYSVRYFAIPAHSSYSYMFQIENMVFTGTSLSAGMIGQTSNMYAERTLRNILKTKLMCFEDNLIIMPFYGPPTSIGVERKYNASFFQDFEKKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NG3</accession>
    <name>Q73NG3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971797.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670742.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11708">
        <property type="protein sequence ID" value="AAS11708"/>
        <property type="gene ID" value="TDE_1190"/>
    </dbReference>
    <dbReference type="GeneID" id="2741151"/>
    <dbReference type="KEGG" id="tde:TDE_1190"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1147"/>
    <dbReference type="eggNOG" id="ENOG5031HFK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126479_1_0_12"/>
    <dbReference type="OrthoDB" id="1951376at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="146" mass="16558" checksum="727DA929E1DC4DEA" modified="2004-07-05" version="1">MKICRKIILLVLTISVLFVFSCKTNEKKNAPAQANGDLSKYELVAEAATKQCPVMLDEITRLDSVQYKGKENALIYNYSIINVKKSDLPANATDLAAGMMRDTMLSKLKGQAALDMFRKDKVKLVYVFKDMEGKDLFVFDFKHTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NL8</accession>
    <name>Q73NL8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971742.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11623">
        <property type="protein sequence ID" value="AAS11623"/>
        <property type="gene ID" value="TDE_1134"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1134"/>
    <dbReference type="HOGENOM" id="CLU_3278172_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="41" mass="4664" checksum="F5F5C2514F956C5F" modified="2004-07-05" version="1">MKIKNYKLKLSLVIVSSILTLLILGSIGFFILKIKLKLGRF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NP7</accession>
    <name>RBFA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name type="ordered locus">TDE_1105</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971713.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670660.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NP7"/>
    <dbReference type="SMR" id="Q73NP7"/>
    <dbReference type="STRING" id="243275.TDE_1105"/>
    <dbReference type="EnsemblBacteria" id="AAS11594">
        <property type="protein sequence ID" value="AAS11594"/>
        <property type="gene ID" value="TDE_1105"/>
    </dbReference>
    <dbReference type="GeneID" id="2740235"/>
    <dbReference type="KEGG" id="tde:TDE_1105"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1064"/>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089475_6_5_12"/>
    <dbReference type="OMA" id="CSLSINH"/>
    <dbReference type="OrthoDB" id="1971380at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000102760" description="Ribosome-binding factor A">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <sequence length="132" mass="14687" checksum="D65816FADF560E39" modified="2004-07-05" version="1">MSEFRLARLGEQIREEISALICSGKIKDPRVSSLLSINRVIVSGDLAYAKVYVSSFLDEHKTKQGVRGLENASGFIRTSLAKKLHVRQCPELTFIFDKSIKEGIDMVNKLESLEYFTDPDEDEGTAGSSEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NU0</accession>
    <name>Q73NU0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter, ATP-binding protein, HlyB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_1062</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971670.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671827.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1062"/>
    <dbReference type="EnsemblBacteria" id="AAS11551">
        <property type="protein sequence ID" value="AAS11551"/>
        <property type="gene ID" value="TDE_1062"/>
    </dbReference>
    <dbReference type="GeneID" id="2740823"/>
    <dbReference type="KEGG" id="tde:TDE_1062"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1022"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="379"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="413"/>
            <end position="420"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="625" mass="70671" checksum="CE57DF8E83D9B231" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P04</accession>
    <name>Q73P04_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971605.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671898.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0996"/>
    <dbReference type="CAZy" id="GH63">
        <property type="family name" value="Glycoside Hydrolase Family 63"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11486">
        <property type="protein sequence ID" value="AAS11486"/>
        <property type="gene ID" value="TDE_0996"/>
    </dbReference>
    <dbReference type="GeneID" id="2739073"/>
    <dbReference type="KEGG" id="tde:TDE_0996"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.957"/>
    <dbReference type="eggNOG" id="COG3408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025779_0_0_12"/>
    <dbReference type="OMA" id="INSLMWD"/>
    <dbReference type="OrthoDB" id="70058at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="PTHR23403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="477" mass="55358" checksum="EBA491667047F91E" modified="2004-07-05" version="1">MNKRDFPRVHFYDQDFVDIYDRTWAWVHDFWHSTGDGKQGTEGFFIYPEADGNFLNQYETIFSSFFFVYSNKNYTPNSALDFFYDRQEENGAIRNRYDFDTKEPVLKRDNPEGLGMPLFAWAEYNIYHKTGNKKRVKDIMPVLIKYMDWIDKMFKSDNGLYKSPLETVNMPNTPRKESVFLTDFNSALAVNALYMSALGDILNDKEIDFQYKRLYFTIKTRINSMMWNEEDGFYYDLDAEGKQIKKKTLAGFWPMLAEIPNEDKAALLVEHLSNPKTFGVDHPFPSLAANEPEYDENGNGACGSVFPILNFVVVKGLEKYNRWEIARECVIRHLYYVLETLSPAGNSKKQGFLWEAYSPVKEGPAQWKGKPAFPRKQYLLSVGLSTISLMIENVIGLSISLPRKTVNWTVPNLEVMGIENLSLKRNLITILSSKSQRGWEIHMESEKLYYFTINILNEKKKTLPIPSGKCSMLIDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P69</accession>
    <name>Q73P69_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_0930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971540.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670316.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0930"/>
    <dbReference type="EnsemblBacteria" id="AAS11421">
        <property type="protein sequence ID" value="AAS11421"/>
        <property type="gene ID" value="TDE_0930"/>
    </dbReference>
    <dbReference type="GeneID" id="2740395"/>
    <dbReference type="KEGG" id="tde:TDE_0930"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.898"/>
    <dbReference type="eggNOG" id="COG1284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063199_0_0_12"/>
    <dbReference type="OMA" id="FITIHDV"/>
    <dbReference type="OrthoDB" id="1747063at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="219"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="281" mass="30482" checksum="CE51FB6D97706764" modified="2004-07-05" version="1">MKEKLLSFFYIVCGVLMIASGIHFFLLPSKLSLGGATGMALVLSKYLPLSTGALLVVVNIFLFALGFLIIGNKFGLKTVCASLGLSGAVWLLEIFVPLQGPIVNDKFLQLVIAVILYGGGVGIVLNQYASTGGSDIFAMILQKYFGLDLGKGCLITDFTITVFAGFAYGPEIALFSLVGVIINGLVIDSTIDGLNMSKYCVINTDKPDELCRFMVELGRSANVYKATGAYTRAERSVIQTVMSRRDFVKLKSYLAANDPKAFMVVTNAHSVFGWHWRRIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P73</accession>
    <name>Q73P73_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphonate ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971536.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682228.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0926"/>
    <dbReference type="EnsemblBacteria" id="AAS11417">
        <property type="protein sequence ID" value="AAS11417"/>
        <property type="gene ID" value="TDE_0926"/>
    </dbReference>
    <dbReference type="GeneID" id="2740391"/>
    <dbReference type="KEGG" id="tde:TDE_0926"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.894"/>
    <dbReference type="eggNOG" id="COG3639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064254_1_2_12"/>
    <dbReference type="OMA" id="RWENNIR"/>
    <dbReference type="OrthoDB" id="1209768at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="271" mass="29987" checksum="79423EF70C037442" modified="2004-07-05" version="1">MIGTTKKIKIRRFSKQRVLILFVLIFLSSLTIISLFQMEKPDYGIQKAFLQFTEYSKDLFFFPKLSQKYSYADIFFSLLVSLSLALLTTVFGVVLAFFLGIAASENLSNKHLVKIIRTAMSLIRSVPTIIWVLIFSVVANIGAEAAVLGMSFHSTAYLVKGFSESFDGIDKKTIEALRACGASYIEIISQAVLPASINNLISWSFFRFEINFGNAVAVGAAAGAGGIGYELFMAGSLNFNMSEVGFISYLIFGTAIILEISSTRIRNRIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PC8</accession>
    <name>Q73PC8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971481.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0871"/>
    <dbReference type="EnsemblBacteria" id="AAS11362">
        <property type="protein sequence ID" value="AAS11362"/>
        <property type="gene ID" value="TDE_0871"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0871"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.841"/>
    <dbReference type="HOGENOM" id="CLU_3190265_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="46" mass="5665" checksum="93C3DB1D34A110F2" modified="2004-07-05" version="1">MTKCGQYEEPLKDYLLYRIFRQKARSLYCFTTEKKLRPPPKRQPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="134" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PG1</accession>
    <name>Q73PG1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion-translocating oxidoreductase complex subunit C</fullName>
            <ecNumber evidence="8">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rnf electron transport complex subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nqrA</name>
        <name evidence="8" type="synonym">rnfC</name>
        <name evidence="11" type="ordered locus">TDE_0838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971448.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682097.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0838"/>
    <dbReference type="EnsemblBacteria" id="AAS11329">
        <property type="protein sequence ID" value="AAS11329"/>
        <property type="gene ID" value="TDE_0838"/>
    </dbReference>
    <dbReference type="GeneID" id="2739615"/>
    <dbReference type="KEGG" id="tde:TDE_0838"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.807"/>
    <dbReference type="eggNOG" id="COG4656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010808_6_0_12"/>
    <dbReference type="OMA" id="YPMGSEK"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00461">
        <property type="entry name" value="RsxC_RnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026902">
        <property type="entry name" value="RnfC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13375">
        <property type="entry name" value="RnfC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01945">
        <property type="entry name" value="rnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="441"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="480" mass="50924" checksum="7F10B9089423238C" modified="2004-07-05" version="1">MGIKSFKGGVHPPERKAVSPSDSVIRVLPSNKSVWIPITQGGMPNTPLVSVGDLVARGQKIAETDKFMSAPVHSSVSGKVKKIEPHLVTGNTENLCFLIEIDEENREEFMPPLDPFTCTKEEALKRVRDAGITGMGGASFPTHVKLSPPPDAKIEYVIANGAECEPYLCTDAATIFSDSDSIVDGLAITMRIVGAKQGIIALEDNKKDLVPVLEKAISKIKANPIAAGAYDISVQLCKTKYPQGGEKTLTDAVVNREIPSGGLPFQIGCVIQNVGTLKAISEAFRLGKPLIDRALTIGGGACEKPLNVIAPIGTCVGDLIPSVVSLKPGVVKIISGGPMMGFAMKNADFPIQKNTSGVLFLTKEEISLEEESPCIGCGKCIDVCSCHLSPVLIVRALNAGNTEEAIRCGLLDCVECGTCAYTCPARIKLVQRVKIGKQIAREEKQKRDAKAAAKAAAAEKKAAEAQKQEPEAKKTEEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PI0</accession>
    <name>Q73PI0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0819</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971429.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682081.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0819"/>
    <dbReference type="EnsemblBacteria" id="AAS11310">
        <property type="protein sequence ID" value="AAS11310"/>
        <property type="gene ID" value="TDE_0819"/>
    </dbReference>
    <dbReference type="GeneID" id="2739561"/>
    <dbReference type="KEGG" id="tde:TDE_0819"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.791"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_12"/>
    <dbReference type="OMA" id="YFAALMC"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="336"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="368"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="578" mass="65316" checksum="8B005D1567C7D84F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PM6</accession>
    <name>RS3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsC</name>
        <name type="ordered locus">TDE_0773</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971383.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670002.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PM6"/>
    <dbReference type="SMR" id="Q73PM6"/>
    <dbReference type="STRING" id="243275.TDE_0773"/>
    <dbReference type="PRIDE" id="Q73PM6"/>
    <dbReference type="EnsemblBacteria" id="AAS11264">
        <property type="protein sequence ID" value="AAS11264"/>
        <property type="gene ID" value="TDE_0773"/>
    </dbReference>
    <dbReference type="GeneID" id="2740313"/>
    <dbReference type="KEGG" id="tde:TDE_0773"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.746"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_12"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="OrthoDB" id="1132353at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000130225" description="30S ribosomal protein S3">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="239" mass="26614" checksum="8AE11EE78FE4D18E" modified="2004-07-05" version="1">MGQKVNPTGLRLGINKTWSSRWYAGPRNYADLLLEDLKIRAMIQEIPECKNADIAEVEIIRHPQRITIMIHTARPGVIIGVKGANIENIGAIIQKKLGKKVQIKIKEVKRAELRAALVAQNVARQLAGRASFRKVLKQACFNTMRSGAQGIKIRISGRLGGAEMSRTEEMKEGRVPLHTLRADIDYGFAEADTTYGKIGVKVWLYSGMMFGGEQKEDAGALLKKQRRPRTEKPAQAGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PN8</accession>
    <name>Q73PN8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971370.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0759"/>
    <dbReference type="EnsemblBacteria" id="AAS11251">
        <property type="protein sequence ID" value="AAS11251"/>
        <property type="gene ID" value="TDE_0759"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0759"/>
    <dbReference type="HOGENOM" id="CLU_2014245_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="123" mass="14076" checksum="F3BB22D52C59087B" modified="2004-07-05" version="1">MSSGTEWNSPAGCLGSVLQPKKVTQQINNKITQNLIVLKYIILIGFSKTYFYKFCKFSKKNKKNAGLTLIYKSFRITSQFSNHTGAEIRLKGKHGVIPSRSRRCKRIVFLKYVTREIGEGLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PN9</accession>
    <name>Q73PN9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron compound ABC transporter, periplasmic iron compound-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971369.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682022.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0758"/>
    <dbReference type="EnsemblBacteria" id="AAS11250">
        <property type="protein sequence ID" value="AAS11250"/>
        <property type="gene ID" value="TDE_0758"/>
    </dbReference>
    <dbReference type="GeneID" id="2739877"/>
    <dbReference type="KEGG" id="tde:TDE_0758"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.733"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_7_0_12"/>
    <dbReference type="OMA" id="YELSESC"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284994" evidence="1">
        <location>
            <begin position="20"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="67"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="331" mass="37393" checksum="4E410E2698E4A311" modified="2004-07-05" version="1">MKKIFFRSMLLLLAVSVFLGCSPKEDQSQNSGKAMSKMEGAHYPVTITTYNYAGEPVDLTFEKAPEKVAAFYQSPIETMLALGLSDKLILAVGLDDPVKDEFKEAFSKVNYRDKRPEKEEIIDMEPDFIFAWSSLFGEKRYGDVKFWHDRGTKTYIWQNSGLKKEDALENEYQDILNIGKIFNVEDKAQEIVDKMKTEIAAAKKHVEGKTKVKAIIIEVEKEGQYRVYGERTIGGQIAMQVGADLVGKDKKGIGKEELIELNPDVIFTVYFGDYIEKDQSIEMLTKDNALQSIAALQNKKVFPINLSEVYASGIRTYDGIKTIISGLYPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PR3</accession>
    <name>Q73PR3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971345.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73PR3"/>
    <dbReference type="STRING" id="243275.TDE_0733"/>
    <dbReference type="TCDB" id="1.B.48.6.1">
        <property type="family name" value="the curli fiber subunit porin, cgsa, csgg (csgg) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11226">
        <property type="protein sequence ID" value="AAS11226"/>
        <property type="gene ID" value="TDE_0733"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0733"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.709"/>
    <dbReference type="eggNOG" id="ENOG5033UPB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047252_0_0_12"/>
    <dbReference type="OrthoDB" id="1657553at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="448" mass="50797" checksum="373212038A249E1D" modified="2004-07-05" version="1">MVVWFIPLKEMNKKLFFVILIVFFFSRPFYAQKVSEKKDIAVFATSYYGRHIPNEFIEMIDEAIMNVFFNLERFNIIGLEYRLASTDVDIFIELINRSREENTELPESVLMGLEAFTKADWEKTVNSYYVVMPIIKDYSISMERYDDLFLGETDGYRVEIALEFYIYSSKEDLREKIDIKISSIDKTYEKAYNTALKSLSKKLDLELRKIEAFTIKTGIIKAEKGTVHFELGKKMGVKLGDEYVVLSEDGRREIGLIVVTETESDFSKGLILYSKKPLNLGDAIKEVPHGPFEYRAYALGEFGLFFAERGLYDGGGTFGINVSGTRGFYRFRPCFGVEMTFDSQSPKILSIGAPITIFGGAEIGNTYLRRLQILPTIQFYYTMIVTDSKKSIPIPAGAGLKAFVHTSFLVTKNFKIGGDVGIKTGATFYNGIGGILRFIAGIGFTIKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-12-15" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q54</accession>
    <name>ACCD_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta</fullName>
            <shortName evidence="1">ACCase subunit beta</shortName>
            <shortName evidence="1">Acetyl-CoA carboxylase carboxyltransferase subunit beta</shortName>
            <ecNumber evidence="1">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">accD</name>
        <name type="ordered locus">TDE_0590</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971204.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672437.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73Q54"/>
    <dbReference type="SMR" id="Q73Q54"/>
    <dbReference type="STRING" id="243275.TDE_0590"/>
    <dbReference type="EnsemblBacteria" id="AAS11085">
        <property type="protein sequence ID" value="AAS11085"/>
        <property type="gene ID" value="TDE_0590"/>
    </dbReference>
    <dbReference type="GeneID" id="2741553"/>
    <dbReference type="KEGG" id="tde:TDE_0590"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.570"/>
    <dbReference type="eggNOG" id="COG0777">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_1_1_12"/>
    <dbReference type="OMA" id="PEGLWIK"/>
    <dbReference type="OrthoDB" id="504557at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01395">
        <property type="entry name" value="AcetylCoA_CT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00515">
        <property type="entry name" value="accD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000389896" description="Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01136"/>
        </source>
    </evidence>
    <sequence length="263" mass="28918" checksum="2436DC6A17634FC7" modified="2004-07-05" version="1">MDCPSCKVSYDEEVFTDNLMVCPHCNCHLRIEPRQRITYLTDENSFQELYPNLKTCNPIEMEGYEEKISAAEEKASLNEAVITGSCKIKGRDALLALMSFHFMGGSMGSVVGEKISRLMLKGATERIPVIIYATSGGARMQEGLFSLMQMAKTSSAAAELDEKGVPLFIMLCDPTTGGVTASFAMLGDITAAEPGALIGFAGPRVIEGTIRQQLPEGFQRAEFQLEKGFVDCIVPRQEQRQFFARMIDAHSLGLKETPKKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q85</accession>
    <name>Q73Q85_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971172.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681728.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0558"/>
    <dbReference type="EnsemblBacteria" id="AAS11053">
        <property type="protein sequence ID" value="AAS11053"/>
        <property type="gene ID" value="TDE_0558"/>
    </dbReference>
    <dbReference type="GeneID" id="2739803"/>
    <dbReference type="KEGG" id="tde:TDE_0558"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.543"/>
    <dbReference type="eggNOG" id="ENOG502Z8Z9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1336434_0_0_12"/>
    <dbReference type="OrthoDB" id="1062129at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="210" mass="25446" checksum="6D2066651D483BF5" modified="2004-07-05" version="1">MTAKKFAQYMEKQCKGINNFSLEAIFEEYIVLVSGKRIGVLYQEKFYVLYAPTFEKTENILPCFKPVNLFNWKYYQFIEVTNLEDKENLEKIIHYVYHELYFLKEVVIDIGFIFQSYRGYPETIYTLYEENLTFLNFAYEKKLIKENPVDREGRIIKLLYTNLDLTETGQKILYDLYNKWLTYTDKNDADSLKRAWNIKQLEKYYQKLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q96</accession>
    <name>Q73Q96_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971161.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0547"/>
    <dbReference type="EnsemblBacteria" id="AAS11042">
        <property type="protein sequence ID" value="AAS11042"/>
        <property type="gene ID" value="TDE_0547"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0547"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.532"/>
    <dbReference type="eggNOG" id="ENOG502Z8KH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_820723_0_0_12"/>
    <dbReference type="OrthoDB" id="584849at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="303" mass="34556" checksum="C2F32BA8A132BD1A" modified="2004-07-05" version="1">MEEPVNKQTDTTKMRFSEFLVYASVILGAVLFALQVIKKGGSGFSNLATAILLPPVMALFNARKRTGRSIFIFMAVAIFSLYMFLVYIIISVPVRAPVFTINNTKIKMAYTTVADIVANGFDIYVKQDNPSGRDYKKLLSSGAFKKYPVDRSILVEKGFRRNNTAIPYANYLLVKDGFVIGSIGLYGHKKKDTVLEDCKIIHLKLDEYCISDARANSIRYCLDDVELLVPLQQETLQKTFDKKLWLVPPKNTTDITQLHYGIKWSTGSDHLFWNEYFAYIHFNESNDMTSFEISTEIARDWNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QB5</accession>
    <name>Q73QB5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971142.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681666.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0528"/>
    <dbReference type="EnsemblBacteria" id="AAS11023">
        <property type="protein sequence ID" value="AAS11023"/>
        <property type="gene ID" value="TDE_0528"/>
    </dbReference>
    <dbReference type="GeneID" id="2741747"/>
    <dbReference type="KEGG" id="tde:TDE_0528"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.514"/>
    <dbReference type="HOGENOM" id="CLU_1383644_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="197" mass="22609" checksum="E72CADF70DFDF876" modified="2004-07-05" version="1">MKTTLFPNWTLDDTDDTGAISEYFHNEKIPFTEETMIKCLKMKRNKYEIYWAVLALRMLGTQKAIQYLKEVSTYKNLDVQGASVLTIAYLAEGSENEYLASLLLNKDFKAKWYAAVAFNHKPDGKAVPYAAKYGVKTIKSSKNKPEAGSLIVEYLARFAPENELAKKIFARINKDFENLSPKEQEVFTVNFPHIFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QH0</accession>
    <name>Q73QH0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heavy metal translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971087.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681568.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0473"/>
    <dbReference type="TCDB" id="3.A.3.32.5">
        <property type="family name" value="the p-type atpase (p-atpase) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10968">
        <property type="protein sequence ID" value="AAS10968"/>
        <property type="gene ID" value="TDE_0473"/>
    </dbReference>
    <dbReference type="GeneID" id="2740520"/>
    <dbReference type="KEGG" id="tde:TDE_0473"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.458"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_3_12"/>
    <dbReference type="OMA" id="FIVAHGV"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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    </dbReference>
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        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
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        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
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        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase-IB_hvy"/>
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    </dbReference>
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        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS10968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="699" mass="75380" checksum="7C15FC98AB80695F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QK6</accession>
    <name>Q73QK6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PBS lyase HEAT-like repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681511.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0437"/>
    <dbReference type="EnsemblBacteria" id="AAS10932">
        <property type="protein sequence ID" value="AAS10932"/>
        <property type="gene ID" value="TDE_0437"/>
    </dbReference>
    <dbReference type="GeneID" id="2740583"/>
    <dbReference type="KEGG" id="tde:TDE_0437"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.424"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035419_0_0_12"/>
    <dbReference type="OMA" id="ESNRYPN"/>
    <dbReference type="OrthoDB" id="429052at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284646" evidence="2">
        <location>
            <begin position="32"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="489" mass="54916" checksum="5CF66C985D35408D" modified="2004-07-05" version="1">MKTLKKELNFFLKPGVLSLLFILSFAVKLGAQETAQPPSENKAAQADEKKKKEVSEFEEKRDTILYGIGDDILELIKRLKADEDDRFDTDLQKVFAETKIPAIREALFAYFAEKKNDCLKADALMLLENKDDAPQETVRSAISYIRDLEIYEGIDFLRQILKDEESEYRDLCISAIGKIGKPEDAVFLTELFDSEASDDEKKSLIIKQNIMFALEDLHTPEIWDFLIRTAEDSDQNSIIRGSAVSALGKIGDERAIPILSEIFESKDPILRTAAIKGIAGFKDVKAKSVLTQAFKDSYYKVRLQAVQSAKEEKAEDAVPFILYRAKKDPENVVKLAAIEALSHFNNAEANEWLIDSFNEERTGLSIRLKIAESLLKNNFDVIFDDVKKAALKAISDKQKSKFSAELGKVISTIENRGTAPIAEAYLNHKDPIFKSIGLDMFKRNKYPELVPLVSLIAEDEKNGALSRRAKDLLQSGNTNSAQNNQTGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QL0</accession>
    <name>Q73QL0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0433"/>
    <dbReference type="EnsemblBacteria" id="AAS10928">
        <property type="protein sequence ID" value="AAS10928"/>
        <property type="gene ID" value="TDE_0433"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0433"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.420"/>
    <dbReference type="HOGENOM" id="CLU_201993_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="54" mass="6299" checksum="DE68228AF98F66B3" modified="2004-07-05" version="1">MKSKNRLFIAIIFILILLYGCKTTDTSKKQNYSQAEYFNMAGSTAKEKKIYQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QQ5</accession>
    <name>Q73QQ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971002.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681413.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0388"/>
    <dbReference type="EnsemblBacteria" id="AAS10883">
        <property type="protein sequence ID" value="AAS10883"/>
        <property type="gene ID" value="TDE_0388"/>
    </dbReference>
    <dbReference type="GeneID" id="2740320"/>
    <dbReference type="KEGG" id="tde:TDE_0388"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.377"/>
    <dbReference type="eggNOG" id="COG1775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114972_0_0_12"/>
    <dbReference type="OrthoDB" id="1938330at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="265" mass="31116" checksum="3C03717429D55BC9" modified="2004-07-05" version="1">MIDISFLENLRREAYVEAAENYLSSANVIGIFGEDLPLDILYAYGLLPVPCEGTDSAIFKFGDMENVCDVIKSSVIYLKTDKCPILFSCSMYLIENTCTHFFNKLKENTDKKVILYKGKSELEKNIQEVYGKKFDNLKYLKAKEILDYIESVLKKIDEYSDLSAEEAFLLRYYTPYILDLERRKKYFDDICNSIKFKTEKNIIQKIIALCPRGSYKTILKEVKKEAYINPKENRVIRLCRGWNNADYGYKYCPYKYNMNVMYQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QT3</accession>
    <name>Q73QT3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970974.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681349.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0360"/>
    <dbReference type="EnsemblBacteria" id="AAS10855">
        <property type="protein sequence ID" value="AAS10855"/>
        <property type="gene ID" value="TDE_0360"/>
    </dbReference>
    <dbReference type="GeneID" id="2741080"/>
    <dbReference type="KEGG" id="tde:TDE_0360"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.349"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OMA" id="MSVMMAT"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="340"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="580" mass="64124" checksum="3B10335E1E0E2B47" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QX6</accession>
    <name>Q73QX6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970931.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956716.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0317"/>
    <dbReference type="EnsemblBacteria" id="AAS10812">
        <property type="protein sequence ID" value="AAS10812"/>
        <property type="gene ID" value="TDE_0317"/>
    </dbReference>
    <dbReference type="GeneID" id="2740516"/>
    <dbReference type="KEGG" id="tde:TDE_0317"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.306"/>
    <dbReference type="eggNOG" id="COG3877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132137_0_0_12"/>
    <dbReference type="OMA" id="YPTAKAR"/>
    <dbReference type="OrthoDB" id="1943427at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018658">
        <property type="entry name" value="DUF2089"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024064">
        <property type="entry name" value="FdhE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09862">
        <property type="entry name" value="DUF2089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144020">
        <property type="entry name" value="SSF144020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="126" mass="13915" checksum="D743A4946A6289B3" modified="2004-07-05" version="1">MIEVIGTCPVCGDSFTVSELHCSKCNSSLKGEFELCEFCRLTKEQKYFVKMFLKNRGSIRDMEKELGISYPTVRNKIEEINAALGLSDGSLPSINVSEVLQKIKNGELSVDSAVSFLTGEPGEEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QX7</accession>
    <name>Q73QX7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0316</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970930.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681273.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0316"/>
    <dbReference type="EnsemblBacteria" id="AAS10811">
        <property type="protein sequence ID" value="AAS10811"/>
        <property type="gene ID" value="TDE_0316"/>
    </dbReference>
    <dbReference type="GeneID" id="2740515"/>
    <dbReference type="KEGG" id="tde:TDE_0316"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.305"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OMA" id="IRIACAD"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="17"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="322"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="355"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="529" mass="59354" checksum="648E43D284017EDF" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-07" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QZ3</accession>
    <name>AMPA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="1">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Leucine aminopeptidase</fullName>
            <shortName evidence="1">LAP</shortName>
            <ecNumber evidence="1">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pepA</name>
        <name type="ordered locus">TDE_0300</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="1"/>
    <dbReference type="EC" id="3.4.11.10" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970914.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681245.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73QZ3"/>
    <dbReference type="SMR" id="Q73QZ3"/>
    <dbReference type="STRING" id="243275.TDE_0300"/>
    <dbReference type="MEROPS" id="M17.013"/>
    <dbReference type="EnsemblBacteria" id="AAS10795">
        <property type="protein sequence ID" value="AAS10795"/>
        <property type="gene ID" value="TDE_0300"/>
    </dbReference>
    <dbReference type="GeneID" id="2740287"/>
    <dbReference type="KEGG" id="tde:TDE_0300"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.288"/>
    <dbReference type="eggNOG" id="COG0260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_2_2_12"/>
    <dbReference type="OMA" id="MKNTGPR"/>
    <dbReference type="OrthoDB" id="356206at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0031">Aminopeptidase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000165806" description="Probable cytosol aminopeptidase">
        <location>
            <begin position="1"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <sequence length="476" mass="52167" checksum="74DC93DD8AB56F9D" modified="2004-07-05" version="1">MKFNIAKKGGVVAQLVFEEKIEGGYLNHLKEKELFSGKAEDVYYTLDSNLKAQLFIGLGKEEKIDLEVLRKTFFKAASELLKNKVEEVELNIPKLNNLCNYKTAEAIAEGMLHATYKYDKFKSDRKEQTEITVNYNPEKGKEDRAEKGINEAVKLMEAVFLTRDLVNQPANVIYPETLAKIAKEKLEAKGVKVTVHGKKEIEALKMEAFLNVARASTKEPKLIVMEYYNNPGSNEKIALVGKGLTYDSGGYAIKPATSMVDMFTDMGGSGTVIGAMHALADLKAKVNVVAVVASCENMISGDGYRNGDIIGSMSGKTIEIINTDAEGRLTLADAVYYATNNLGATKLIDLATLTGACVSALGEQVSGAVTNNDEFFSELVKANERAGEIVWRMPTIEYYKKMNESKVADLKNSGGKLGGMMTAGLFVGSFLAKEDIPWIHIDIAGTAYITEKFGYLKENATGTLVKSLYYMLSKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R32</accession>
    <name>Q73R32_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-sulfur cluster-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970875.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681189.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0260"/>
    <dbReference type="EnsemblBacteria" id="AAS10756">
        <property type="protein sequence ID" value="AAS10756"/>
        <property type="gene ID" value="TDE_0260"/>
    </dbReference>
    <dbReference type="GeneID" id="2739685"/>
    <dbReference type="KEGG" id="tde:TDE_0260"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.255"/>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_918090_0_0_12"/>
    <dbReference type="OMA" id="ENCSACK"/>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0408">Iron</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="237"/>
        </location>
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        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS10756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="303" mass="33868" checksum="3823F5EA4944217D" modified="2004-07-05" version="1">MKAVIIVFSPSGHTLIAAHMIQKKIKDKGGAADIINITKDDSLLFASKSERQKILEDRLQDFDVLFVGAPVYAGHAESHILSILESLPLPDQKRSKIAVPFITYGGAHSFIALEEMGRALKKKKYVPVLGIKLASFHTLSRFFHTKILENKPGDMEEGLIETAVNKVFALCSHKEHIKDNSASFAYTKGPMRFILKLLSQEKIHGKFKTVSIIRENCSACKKCISVCPINNFIFTDGRVSIKNQKNCILCGECFYNCGCNAIDFAYRTVAQKRLNDGNIVFEKDISAIYPKKYGYINNKGDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RE8</accession>
    <name>Q73RE8_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0141"/>
    <dbReference type="EnsemblBacteria" id="AAS10639">
        <property type="protein sequence ID" value="AAS10639"/>
        <property type="gene ID" value="TDE_0141"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="34" mass="3643" checksum="EC84B7F1133531C4" modified="2004-07-05" version="1">MNFYFSYAKLTSAGVLLQAENIPAKGCPHGCPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RJ9</accession>
    <name>Q73RJ9_TREDE</name>
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        <submittedName>
            <fullName evidence="3">Transglutaminase-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0089"/>
    <dbReference type="EnsemblBacteria" id="AAS10587">
        <property type="protein sequence ID" value="AAS10587"/>
        <property type="gene ID" value="TDE_0089"/>
    </dbReference>
    <dbReference type="GeneID" id="2741704"/>
    <dbReference type="KEGG" id="tde:TDE_0089"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.90"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_492500_0_0_12"/>
    <dbReference type="OMA" id="TSHKDII"/>
    <dbReference type="OrthoDB" id="353872at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
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        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
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        <property type="entry name" value="IPT_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="418"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="559" mass="62515" checksum="619198E4EE1AF0B3" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RM7</accession>
    <name>Q73RM7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fic family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673299.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0061"/>
    <dbReference type="EnsemblBacteria" id="AAS10559">
        <property type="protein sequence ID" value="AAS10559"/>
        <property type="gene ID" value="TDE_0061"/>
    </dbReference>
    <dbReference type="GeneID" id="2741676"/>
    <dbReference type="KEGG" id="tde:TDE_0061"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.62"/>
    <dbReference type="eggNOG" id="COG3177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046381_0_0_12"/>
    <dbReference type="OMA" id="EFKGAWR"/>
    <dbReference type="OrthoDB" id="1232677at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003812">
        <property type="entry name" value="Fido"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036597">
        <property type="entry name" value="Fido-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040198">
        <property type="entry name" value="Fido_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13504">
        <property type="entry name" value="PTHR13504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02661">
        <property type="entry name" value="Fic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140931">
        <property type="entry name" value="SSF140931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51459">
        <property type="entry name" value="FIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fido" evidence="4">
        <location>
            <begin position="108"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="201"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for autoinhibition of adenylyltransferase activity" evidence="3">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640198-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="348" mass="39633" checksum="0908AAB3AD53F40B" modified="2004-07-05" version="1">MRPFNYSEIKNQKWDSGTLGLIAAIYKEAGKQEMYLKQRPEELEKLVEIAKIQSTEASNAIEGIVTTSTRIKQLVKEKTTPKNRDEQEIAGYRDVLNIIHESFDAIPLSQNYILQLHKILYSHMNNPMAGRIKSVQNYISAAYSDNHTEILFTPLAPFETSEALDKICEEYNRVIGNMEVEPLIAIPVFIHDFLCIHPFNDGNGRMSRLLTTLLLYRNGFYVGKYISLEAKIAKNKDLYYDALGRAQIGWHEGEEDVVPFIKYLLGTVLAAYRDFADRFALVEIKLPALETVRRAALNKIGRFTKQDIRELCPSLSISSIEGGLRKLVSAGELKREGSGKNICYYRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RQ5</accession>
    <name>Q73RQ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolipoprotein diacylglyceryl transferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970647.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680889.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0030"/>
    <dbReference type="EnsemblBacteria" id="AAS10528">
        <property type="protein sequence ID" value="AAS10528"/>
        <property type="gene ID" value="TDE_0030"/>
    </dbReference>
    <dbReference type="GeneID" id="2741645"/>
    <dbReference type="KEGG" id="tde:TDE_0030"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.32"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_1_2_12"/>
    <dbReference type="OMA" id="FTVIIDI"/>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="259" mass="29880" checksum="0AECA2A091FB3629" modified="2004-07-05" version="1">MQPYISFFKFEIPSYGLMIALGIIVANIIGGIVIKKEKLDINDFIIIEAYLFLSGIIGAKLLYLLIAKDSIEWSKIFDLNYFHSLIESGFVFYGGVIGGLLIIPFIKKIHKIKVEVYLKKSIFMLPLIHAFGRVGCFLAGCCYGIPYCGYFNVVFPKNSFAPQGINLFPIQLCEAFFLILLSFFLLYLTLKNKSRLTVLIYLFCYSIIRFILEFLRYDSARGKVLFFSTSQWISLIILIYTIIYFSKHCIFSKNRLRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RS0</accession>
    <name>Q73RS0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970632.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676283.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0015"/>
    <dbReference type="EnsemblBacteria" id="AAS10513">
        <property type="protein sequence ID" value="AAS10513"/>
        <property type="gene ID" value="TDE_0015"/>
    </dbReference>
    <dbReference type="GeneID" id="2741630"/>
    <dbReference type="KEGG" id="tde:TDE_0015"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.17"/>
    <dbReference type="eggNOG" id="ENOG5030DBM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_818713_0_0_12"/>
    <dbReference type="OMA" id="CQQETIF"/>
    <dbReference type="OrthoDB" id="1890188at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="345" mass="37597" checksum="13C8474B6A5B627A" modified="2004-07-05" version="1">MKFRRYIFILIPMIFIGFTACNNRPIFAAIEQEVELKEFSVGGNVLSLVATDTMVYASNLAGVYSKSKNYDGPWSKILPAERTQKLAKNAANVFASFVTGPVKFYDESTKTWSAVSGSDDIHVIAGDTTVFGYDSNQKKVFKIGIAGINNPIATGEVNFLYAAGNYVVVQSKNSAKLYKADASPAVEISNLPSGVKGMCSTGNPNEVFVLAGSTVYYINGGTWNNKISISKSPVSISYFKERKTILLGCDKGYTEIQLDNAHTTDLSKAKQLNPGNSGSTTPPGSYSQYQTTLGSYYTYPVLGVERGNAGSGKYAVFMGIYSGTITRNTGLWGFYSDKKREWNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="145" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RS7</accession>
    <name>Q73RS7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Copper-translocating P-type ATPase</fullName>
            <ecNumber evidence="13">3.6.3.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">TDE_0008</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.4" evidence="13"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970625.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680864.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0008"/>
    <dbReference type="EnsemblBacteria" id="AAS10506">
        <property type="protein sequence ID" value="AAS10506"/>
        <property type="gene ID" value="TDE_0008"/>
    </dbReference>
    <dbReference type="GeneID" id="2741623"/>
    <dbReference type="KEGG" id="tde:TDE_0008"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.9"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_12"/>
    <dbReference type="OMA" id="ITFFGWM"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="828"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS10506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="891" mass="94685" checksum="ACE6BD0430896CF1" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7ITG6</accession>
    <name>F7ITG6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide/dipeptide ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971678.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671815.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1070"/>
    <dbReference type="EnsemblBacteria" id="AAS11559">
        <property type="protein sequence ID" value="AAS11559"/>
        <property type="gene ID" value="TDE_1070"/>
    </dbReference>
    <dbReference type="GeneID" id="2740831"/>
    <dbReference type="KEGG" id="tde:TDE_1070"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1030"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_2_12"/>
    <dbReference type="OMA" id="WPGMGTF"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="121"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="341" mass="38580" checksum="EC45F94FAD81DF0D" modified="2011-07-27" version="1">MANNNVSGSKSLFEILFPYVRYIFKRLVSIIPVLIIMSVAIFILINLMPGDPILAMLDPEKTKAMTPEERALYIENMRKFLGYDKGPVERYFLWMGDTFRGEFGYSIKYNKPVNEFIGTYIKRSFRINIWGFLLAFLISIPVGITAAVKKNSFFDKTVTVLTIVGISLPSFFLALLLIMVFVIFMQILPFSGMSDPRGILPDWHYIILPVTVVVLTSLVGLIRYVRSAMIEILKSDYIRTARAKGLSEKVVIYRHAFQNALIPVVTLIGLYIPGLFGGSIVVEKIFAYPGMGLLMNYAYGFKDRAVLQTVLLFFGLLTLLGNIFIDVGYMVVDPRIREGKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>P60974</accession>
    <name>LGT_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="1">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lgt</name>
        <name type="ordered locus">TDE_1399</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972005.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678985.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P60974"/>
    <dbReference type="SMR" id="P60974"/>
    <dbReference type="STRING" id="243275.TDE_1399"/>
    <dbReference type="EnsemblBacteria" id="AAS11916">
        <property type="protein sequence ID" value="AAS11916"/>
        <property type="gene ID" value="TDE_1399"/>
    </dbReference>
    <dbReference type="GeneID" id="2741266"/>
    <dbReference type="KEGG" id="tde:TDE_1399"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1341"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_1_0_12"/>
    <dbReference type="OMA" id="TDVPWAI"/>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000172705" description="Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <sequence length="338" mass="38424" checksum="337ED5A3BB71ECCC" modified="2004-04-26" version="1">MLLAIQYPSWLHPEIIPGLPFLRWYGLMYLVAFGIAYFLFSYQVKHGEFERYSGCQKAMTQDDISDLFIWGILGLILGARIFGTLVYNPETYLKAPWLIFWPFARDGAGNLTFTGFQGMSYHGGFIGGFLGVILWTKKSKFKFAAVADLMAVSIPLGYTFGRLGNFANGELYGRITTSKIGMIFPQTPISDRFYLAESWVRDFAEQAGLLVQDGASMINLPRHPSQLYEAFFEGIILWLILWLLRKKKPFDGFLVCVYTLGYGFFRFFIEYFRQPDANKGYPISFGTGAANIYVYESWKNISTGQILCSLMILASLAAMLILYLQEKKLKEKKGNIDG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-06-07" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>P61708</accession>
    <name>SYA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>Alanine--tRNA ligase</fullName>
            <ecNumber>6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Alanyl-tRNA synthetase</fullName>
            <shortName>AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">alaS</name>
        <name type="ordered locus">TDE_1659</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two domains; the N-terminal catalytic domain (in this organism this is shorter than usual) and the editing domain; the C-terminal C-Ala domain found in most orthologs is missing. The editing domain removes incorrectly charged amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972264.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679355.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61708"/>
    <dbReference type="SMR" id="P61708"/>
    <dbReference type="STRING" id="243275.TDE_1659"/>
    <dbReference type="EnsemblBacteria" id="AAS12175">
        <property type="protein sequence ID" value="AAS12175"/>
        <property type="gene ID" value="TDE_1659"/>
    </dbReference>
    <dbReference type="GeneID" id="2739000"/>
    <dbReference type="KEGG" id="tde:TDE_1659"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1586"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_0_2_12"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="OrthoDB" id="91428at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000075236" description="Alanine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="600" mass="67091" checksum="575D13322A37E394" modified="2004-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q3V8B5</accession>
    <name>Q3V8B5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Flagellar biosynthetic protein FlhB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">flhB</name>
        <name evidence="13" type="ordered locus">TDE_0054</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the type III secretion exporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970671.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680909.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0054"/>
    <dbReference type="EnsemblBacteria" id="AAS10552">
        <property type="protein sequence ID" value="AAS10552"/>
        <property type="gene ID" value="TDE_0054"/>
    </dbReference>
    <dbReference type="GeneID" id="2741669"/>
    <dbReference type="KEGG" id="tde:TDE_0054"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.56"/>
    <dbReference type="eggNOG" id="COG1377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041013_1_2_12"/>
    <dbReference type="OMA" id="DEYKQQE"/>
    <dbReference type="OrthoDB" id="1424100at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:bacterial-type flagellum assembly"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FlhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
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        <property type="entry name" value="PTHR30531"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
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        <property type="entry name" value="flhB"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11 12" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
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            <end position="82"/>
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            <end position="135"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="172"/>
            <end position="193"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
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            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS10552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="390" mass="44434" checksum="08EAB7744E23B4BA" modified="2011-07-27" version="1">MISGKSPLLYRKYFSQEDLLLNKTIGLQWFAAEDEGRTEDPTEYKIRKAREEGRVAKSQDLNAAMVVLLPVISLIIMGPYIFKSLMQVIAFFFERCTTEDVVNGTWFRIFVLYFFKTVFPITGVALISGVLGNIIQNRGFLFSTKPIQPDFKRVTPNFARFFKRALFSAEGLFNLAKSLFKVVIIGFIGYLVIKNNITKMIALLQSDFPNSIIFIAKTAAQILVYAAVALVLLSIPDYFFQKRQFSESLKMSKTEVTDEYKELEGDPMVKAQINRQMQAILQKTGIKNVPDADVVITNPTHYAVALQWKQGIMPAPMVISKGVDATAQNIKRIARENNIPTIENVPLARALYANVDLGQIIPSEYYQSLSIIFLKIYSMKEKEMLRKRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J86</accession>
    <name>Q73J86_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="protein sequence ID" value="AAS13207"/>
        <property type="gene ID" value="TDE_2690"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3105032_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="51" mass="5747" checksum="4C094BD6A6CDA8BD" modified="2004-07-05" version="1">MQINNPDAEHRGCCSHKVVAVGFNTLCYDAERRGIKTSARIKIIKLSFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JB0</accession>
    <name>Q73JB0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Inosine-5'-monophosphate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.205</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">guaB</name>
        <name evidence="12" type="ordered locus">TDE_2665</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="12"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973263.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680711.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2665"/>
    <dbReference type="EnsemblBacteria" id="AAS13182">
        <property type="protein sequence ID" value="AAS13182"/>
        <property type="gene ID" value="TDE_2665"/>
    </dbReference>
    <dbReference type="GeneID" id="2741110"/>
    <dbReference type="KEGG" id="tde:TDE_2665"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2518"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_12"/>
    <dbReference type="OMA" id="HDYHMTL"/>
    <dbReference type="OrthoDB" id="532857at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="167"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="312"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS13182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="504" mass="55652" checksum="119DC3C4C747B28A" modified="2004-07-05" version="1">MAFFYDEPSHTFSEYLLVPRLSGVEHIPQAVSLKTPLTKYKKGEEPKISLNIPLVSSIMQSVSDHNMAVALAREGGLSFIFGSQSIESEAKMVTKVKNYRAGFVESDSNLTPEHHLSDVLDLKDRTDHTTVAVTHDGTGHGKLLGVVTGRDYRIGHTDLNTKVKEFMTPIERLHVAEEGISLKKAQDIIWEFKLNSLPILDKKGCLVAFVFRKDYESNTENPLELLDEKKRYMVGAGINTRDYEERVPALVEAGADVLCIDSSDGFSDWQKQTIQFVKEKYGDSIPIGAGNVVDADGFNFLADAGADFIKVGIGGGSICITRETKGIGRGQATALIEVAKARDEYFKKKGVYIPICSDGGIVFDYHITLALAMGSDFCMLGRYFARFDESPTNKVLINGNYMKEYWGEGSARARNWQRYDSGGEKKLSFEEGVDSYVPYAGKLHDNVAVTLNKIRSTMCNCGVLSIPEFQRDAKITLVSSASIIEGGPHDVVLKDMSHSSSSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JB5</accession>
    <name>Q73JB5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DZANK-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973258.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667147.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2660"/>
    <dbReference type="EnsemblBacteria" id="AAS13177">
        <property type="protein sequence ID" value="AAS13177"/>
        <property type="gene ID" value="TDE_2660"/>
    </dbReference>
    <dbReference type="GeneID" id="2741105"/>
    <dbReference type="KEGG" id="tde:TDE_2660"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2514"/>
    <dbReference type="eggNOG" id="COG1933">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144861_0_0_12"/>
    <dbReference type="OMA" id="ENCNTEV"/>
    <dbReference type="OrthoDB" id="1938458at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS13177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="119" mass="13868" checksum="252AABDBB03293C3" modified="2004-07-05" version="1">MDKVQKGHSPKFFCENCGQEVKRNTKVCPHCGRFFASVRCPSCNYMGHTDEFINGCPSCGFAVSSDSNKNTKKYHRNKLKEYRAKYKSNRYDDPLPWWIYSLVIGSLALLIIYIFYFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JE8</accession>
    <name>Q73JE8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973225.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680648.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2627"/>
    <dbReference type="EnsemblBacteria" id="AAS13144">
        <property type="protein sequence ID" value="AAS13144"/>
        <property type="gene ID" value="TDE_2627"/>
    </dbReference>
    <dbReference type="GeneID" id="2740801"/>
    <dbReference type="KEGG" id="tde:TDE_2627"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2484"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_6_0_12"/>
    <dbReference type="OMA" id="MSEATHQ"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="202" mass="23320" checksum="AD6DB80C93F7F1D5" modified="2004-07-05" version="1">MPRDKTANHIKIIAAAKAEFMEKGFDKSSMRSISKRCGMTAAGIYRHCVDKEDLFDQIVAPAVDRINAWLDAHVARYAEAVQKEKHIQWRDSEIDMMREIIYPNMEEYHLLLAKSRGSKYEHFLHDLTEGQQTQLLKYLPMLKAQGYAVKDIDSKELHLLLSAYTTALFEPVIHNYSLEEALHCLKAVEAFFVPGWKQLFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JF8</accession>
    <name>Q73JF8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973215.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673627.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2617"/>
    <dbReference type="EnsemblBacteria" id="AAS13134">
        <property type="protein sequence ID" value="AAS13134"/>
        <property type="gene ID" value="TDE_2617"/>
    </dbReference>
    <dbReference type="GeneID" id="2740791"/>
    <dbReference type="KEGG" id="tde:TDE_2617"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2474"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846407_0_0_12"/>
    <dbReference type="OrthoDB" id="477513at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="281"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="333" mass="36908" checksum="CAF478B1F0A44DA4" modified="2004-07-05" version="1">MPKAINYKANSVVYFSGDFDERVFLLNTGSIALTSIDIETGEQVTDYIKTGEFFGVKSALGNYPREESAMVLTDSIVYSFTSKEFEAFAQTNTRIILQMIKVFSRQLRTIHKQLASLLDSEEEKNPEEGLFNVMNAFYSSQHYKAAGQVGTRYKAIYPNGKYISQVDQIVRSTAEVAGRSFGNAEGHNNDAVLAHHEKPAAVTDGTVHLAYNKAEDLFEKGEFEAAYDQYHAVIEAGAGDEITDNAYIGAGKSLHSQKEYVRCLQLLTGFISQHPKSSKIGDALMYLGMCYMDMERPDKAIAFFDKAAILSGADIIGKIRELQKECSSRLQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JL6</accession>
    <name>Q73JL6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973001.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680331.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2402"/>
    <dbReference type="EnsemblBacteria" id="AAS12920">
        <property type="protein sequence ID" value="AAS12920"/>
        <property type="gene ID" value="TDE_2402"/>
    </dbReference>
    <dbReference type="GeneID" id="2740704"/>
    <dbReference type="KEGG" id="tde:TDE_2402"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2268"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_1_0_12"/>
    <dbReference type="OMA" id="YHFYPGS"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="73"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="297" mass="33934" checksum="7309B9785BC46561" modified="2004-07-05" version="1">MKEAEFWKKESSFLENEDDKIRCLLCPHRCLIKEGQSSRCLSRKNIGGKLYSLNYGKVLGAALDPIEKKPLYRFYPSTYIFSVGTFGCNFDCLFCQNHSLVHSVPKKIEEKTNNYQDEVSPEELIGAVLKTPSIGIAFTYNEPTVWYEYIKDVLPIAKEKDLKTVLVTNGFIEEEPLKKILPMIDAMNIDLKSFSPQFYTKVCKGKIEPVINTIKKAASQIHLEVTCLVIEGYNSGDDEMEALSQMLAKIRPDIPLHISAFYPAYKMRDKAPTRPETIRHLCKTAQRNLKYVYPGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JV5</accession>
    <name>Q73JV5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2506</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973104.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680474.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2506"/>
    <dbReference type="EnsemblBacteria" id="AAS13023">
        <property type="protein sequence ID" value="AAS13023"/>
        <property type="gene ID" value="TDE_2506"/>
    </dbReference>
    <dbReference type="GeneID" id="2741479"/>
    <dbReference type="KEGG" id="tde:TDE_2506"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2373"/>
    <dbReference type="eggNOG" id="COG1313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062674_0_0_12"/>
    <dbReference type="OMA" id="GGEPTPN"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="PTHR43075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="64"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS13023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="331" mass="37274" checksum="5DACC25BC6439420" modified="2004-07-05" version="1">MLSFEDFSFKEYDSCTLCPKNCKVNRNKGEKGFCRETRDLRLAWAGLHFGEEPPITGAGGSGTIFVTGCNLRCSFCQNYQISQEGMGRAVNLEEFVNLCFVLEKEGAENINIVTGSHAIPAIALSLKEAKDRGLKIPVVWNSSAYETEEAISLLSDCVDGWLPDLKTLNPQISSQVFYAPDYPETATRAILKMAGLSPLKICMENKKKYPLGKLYSGVIVRHLALPSRIADSKAVLRWFAKNLRGRALISVMTQYTPVKRTSGIKNYSLFENRMLNLKEDETLKDLLSSLKIDEGFYQELVASDDWLPDFNRVQTFSSELSKPLWHWKQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JX5</accession>
    <name>Q73JX5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3887 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973136.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680505.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2538"/>
    <dbReference type="EnsemblBacteria" id="AAS13055">
        <property type="protein sequence ID" value="AAS13055"/>
        <property type="gene ID" value="TDE_2538"/>
    </dbReference>
    <dbReference type="GeneID" id="2739050"/>
    <dbReference type="KEGG" id="tde:TDE_2538"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2401"/>
    <dbReference type="eggNOG" id="ENOG5031H76">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1884868_0_0_12"/>
    <dbReference type="OrthoDB" id="2047497at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024981">
        <property type="entry name" value="DUF3887"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13026">
        <property type="entry name" value="DUF3887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3887" evidence="1">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="135" mass="15940" checksum="B316BFC023801CD2" modified="2004-07-05" version="1">MKPLKIFFLFVSFVLLWSCKPKETSETFHIPFLKEKAEEIIFMINDKDWEGIRNLSTEEFKKNLDEEFINVNTKIFFEPAGKYLYTKEAYFLETKDKNSGEVIGVVIVKVGYENKTLCYTFNFAKDTKLIGFFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K03</accession>
    <name>Q73K03_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973160.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680541.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2562"/>
    <dbReference type="EnsemblBacteria" id="AAS13079">
        <property type="protein sequence ID" value="AAS13079"/>
        <property type="gene ID" value="TDE_2562"/>
    </dbReference>
    <dbReference type="GeneID" id="2739927"/>
    <dbReference type="KEGG" id="tde:TDE_2562"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2421"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_3_1_12"/>
    <dbReference type="OMA" id="WVVLRGM"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS13079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="269" mass="28592" checksum="4AFE1DD584995EF1" modified="2004-07-05" version="1">MLQYGFMQNAFIVSFFIGILCPSIGLFLVLRRYSLIGDTLSHSSLAGVTLALASGINPILGAFIFTTAAGALIEALRNAFKEYQDLILSIVLSLSVGIAITLISSGTVRANAETYLFGSVLTVSSSDLITVIALSILSLVTLGLMYHKMVYIALDEDIAKIIGVKVRLINYLFSGLTAATIAVSLKIVGMLVLSSMIALPVATALQLKISFKKTLIFSIFISVADIMLGLVLSYHLNVAPGGFTALVSVIVLILTIGINSFLKHNKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K27</accession>
    <name>Q73K27_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973188.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2590"/>
    <dbReference type="EnsemblBacteria" id="AAS13107">
        <property type="protein sequence ID" value="AAS13107"/>
        <property type="gene ID" value="TDE_2590"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2590"/>
    <dbReference type="HOGENOM" id="CLU_3349898_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="37" mass="4713" checksum="8DE5BCFA0EDBD7A4" modified="2004-07-05" version="1">MTYYMNLCRFVQIKEYDDEKNMYIFKLFTYGDFFGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K43</accession>
    <name>Q73K43_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972978.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680303.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2379"/>
    <dbReference type="EnsemblBacteria" id="AAS12897">
        <property type="protein sequence ID" value="AAS12897"/>
        <property type="gene ID" value="TDE_2379"/>
    </dbReference>
    <dbReference type="GeneID" id="2740681"/>
    <dbReference type="KEGG" id="tde:TDE_2379"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2247"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_11_0_12"/>
    <dbReference type="OrthoDB" id="1854645at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="379" mass="42554" checksum="C3F7F417F1557DD8" modified="2004-07-05" version="1">MKAFLKITLIAIKDNFITFILVYLCLPIFFVGYNGFLQKDKFKAETNEKTISVFLDDEDKTFLSEQLISTLNSSSLKDFIQIEDETNAKYKIKIPKGYQTAVEENKEFDILIIGKEKSSASITFLSNIIKNISSSINGNYKMAKAITASGQSKELMDKYLNIQKESSKPIGKIFMHPALHSMSSYEAYAISISIFLFFMFVMEILNPTYKKKAAGLTLRINSMPKKAAYIFNAQIISLALKVFVAITIYLLIFRLLRVSFMGNPILLLIYAASFSLVTGCIACSLVSINKQELVYTIVIIIFFVFVVLGTVLFSIPNENKIAKLFLKCNVSQIITNPLRNIVVENSFGGMIGSLLIMLTFGAVFYTLGLLMASFKKTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KE0</accession>
    <name>Q73KE0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972878.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2278"/>
    <dbReference type="EnsemblBacteria" id="AAS12797">
        <property type="protein sequence ID" value="AAS12797"/>
        <property type="gene ID" value="TDE_2278"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2278"/>
    <dbReference type="HOGENOM" id="CLU_2482360_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="87" mass="10634" checksum="1A5F6866C4B8DFF3" modified="2004-07-05" version="1">MRVIILNYLRKAFIKVFICEWFILYFNRPGPHTPGAIFLYIVQNKHSRFKVLMPINKLKKIYSKLLKRYLFFFIYVLGCVSWKKIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KH9</accession>
    <name>Q73KH9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972839.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2239"/>
    <dbReference type="EnsemblBacteria" id="AAS12758">
        <property type="protein sequence ID" value="AAS12758"/>
        <property type="gene ID" value="TDE_2239"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2239"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2113"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_1_0_12"/>
    <dbReference type="OMA" id="WFINARY"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="52"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="330" mass="36070" checksum="CA7F91D198572FAF" modified="2004-07-05" version="1">MLDEDSGSEGSGNWNSQSYDFVLVTPPANGIVGVAPDYALPYTDEWWKGVFRAGRKVKLSPYKLGKTEVTYKLWKEVYDEAVKPEHGYTFQNAGQKGSDGTGNDEEQPVTMVSWRDCIVWCNAYTEMKLGSDEQCVYRESNASGAAVLKDATATTACDAAYADMGKKGFRLPTEAEWEYAARRQNDNTNATDYGEGGSNVWLTKLNSASGAKDRWDTAETGEVAWYSGNSGNKTHPVGKRRANALGLYDMSGNVWEWCFDGYDNNPASNDAAYVQGGIVTDPQGGASGSARVDRGGSWDNGVRYCSVGFRFSCSPGHRYYGLGFRLACLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KJ6</accession>
    <name>Q73KJ6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972822.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680076.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2222"/>
    <dbReference type="EnsemblBacteria" id="AAS12741">
        <property type="protein sequence ID" value="AAS12741"/>
        <property type="gene ID" value="TDE_2222"/>
    </dbReference>
    <dbReference type="GeneID" id="2739498"/>
    <dbReference type="KEGG" id="tde:TDE_2222"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2099"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080737_0_0_12"/>
    <dbReference type="OMA" id="EHYSNMD"/>
    <dbReference type="OrthoDB" id="706925at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="76"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="294" mass="33111" checksum="5E977E351954849E" modified="2004-07-05" version="1">MQQTLMEYVKDILPEIAKHTMKNPAVTPENVLQKGNPALSKILDDMVDDLALENSEFRHPEHLKEFLDEVNKGKKGIILAEHYSNMDYPAFINLMKKTGTKGTELAEKCIAMAGLKLGEDNPYVAAFASAYDRIYIYPSRSIKSIKDPEVLAEELKRSKMINLASMRALEKAKEAGRVILVYPAGTRYRPGKPETKKGVKEIDSYIKMSDIMLLVSSNGNCLRISDSGDMTEDTVWKDRLIFDASPVINCEEYREKIKAEHGDLTGIDKKQAVVDQVMADLEKMHEANEIGRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KK9</accession>
    <name>Q73KK9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CarB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972809.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73KK9"/>
    <dbReference type="STRING" id="243275.TDE_2209"/>
    <dbReference type="EnsemblBacteria" id="AAS12728">
        <property type="protein sequence ID" value="AAS12728"/>
        <property type="gene ID" value="TDE_2209"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2209"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2086"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029016_5_0_12"/>
    <dbReference type="OMA" id="GYMSGWT"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="BRENDA" id="6.3.2.49">
        <property type="organism ID" value="6426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="98"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="543" mass="60680" checksum="A90C64DAD0E5BFC4" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KT6</accession>
    <name>Q73KT6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalamin biosynthesis protein CbiM, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2131</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972732.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668179.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2131"/>
    <dbReference type="EnsemblBacteria" id="AAS12651">
        <property type="protein sequence ID" value="AAS12651"/>
        <property type="gene ID" value="TDE_2131"/>
    </dbReference>
    <dbReference type="GeneID" id="2739390"/>
    <dbReference type="KEGG" id="tde:TDE_2131"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2013"/>
    <dbReference type="eggNOG" id="COG0310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052508_1_0_12"/>
    <dbReference type="OMA" id="PWGTSGH"/>
    <dbReference type="OrthoDB" id="1632785at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="197" mass="20827" checksum="C3DA5FF3FC1F9659" modified="2004-07-05" version="1">MHISDGGLSTAVCAVGYAASAVGIAFAVKGTKEEDIPKISLMAGTFFAISLIMIPIPPSSVHPLMCGLIGIIVGRRAPLAFFPALLLQALLFQHGGITTLGANTLMLSISSILSAIIFYNWKSDNVLLKGMVVGALSVIFVVLVLSVLLMTGGSFAKETFIAIFVSHSVVMAVEAVITGFAVKLMMKARPDWFKRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KU8</accession>
    <name>Q73KU8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycine reductase complex selenoprotein GrdB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">grdB-2</name>
        <name evidence="2" type="ordered locus">TDE_2119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GrdB/GrdF/GrdH family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972720.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957155.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2119"/>
    <dbReference type="GeneID" id="2739378"/>
    <dbReference type="KEGG" id="tde:TDE_2119"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2002"/>
    <dbReference type="eggNOG" id="COG1978">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053106_0_0_12"/>
    <dbReference type="OMA" id="NPDHIES"/>
    <dbReference type="OrthoDB" id="571652at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030700">
        <property type="term" value="C:glycine reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030699">
        <property type="term" value="F:glycine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010186">
        <property type="entry name" value="Gly_red_sel_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010187">
        <property type="entry name" value="Various_sel_PB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07355">
        <property type="entry name" value="GRDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01917">
        <property type="entry name" value="gly_red_sel_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01918">
        <property type="entry name" value="various_sel_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <keyword evidence="2" id="KW-0712">Selenocysteine</keyword>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="431" mass="46302" checksum="CFC58B92416762C7" modified="2008-02-26" version="2">MSKVIVHYINQFFAGKGGEDMADYKPEVIDGTAGPGTGIQGALGDAGKIVKTIICGDNFFNEHEEEAVAFVKKVLTDTKADLLIAGPGFNAGRYGMACGNAAKVAFELGIPAISGLYEENPGYDVFKAFMYTIKTGNSAVSMREAVPAIGALAKKLLKGEQICCPEKEGLLPRGVRQNYFAEERGAKRAVDMLIKKIKGEAFVTEYPMPVFDRVPPQPPVKDITKAKIALVTSGGVVPKGNPDHIEASNASHYGEYSIAGMAALSSKDSETAHGGYDPTYCNANPNRVLPVDVLRDLEKEGKIGKLHDKYYTTVGNGTAVKRAKKFAEEIVQKLVKDGVQAVILTSTUGTCTRCGATMVKEIERFLPVVHIATVVPISKTVGANRIVPAVAIPHPLGDPKMNDADEKKLRRSLVEKALKALETPISEQTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KX6</accession>
    <name>Q73KX6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter, amino acid-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972692.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679892.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2091"/>
    <dbReference type="EnsemblBacteria" id="AAS12611">
        <property type="protein sequence ID" value="AAS12611"/>
        <property type="gene ID" value="TDE_2091"/>
    </dbReference>
    <dbReference type="GeneID" id="2740330"/>
    <dbReference type="KEGG" id="tde:TDE_2091"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1975"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_4_12"/>
    <dbReference type="OMA" id="FDKSEPY"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="47"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="277" mass="31014" checksum="AC9F1BC5DB10A16E" modified="2004-07-05" version="1">MRNKLNSKAVFFAVILLFSLIFSCKKNEINEISSNDVSLAEVLVRSKIIVGVNAYNPPICFYNNKNEIIGFDIDVFEEIADIMNIKAEFRTIVPTEVNELINTGAIDCIASGFSYSDERNEAYELSQAYLRNSVVILTLRSRNIRTMADLKGKKIGGQKGSLGADLIKNNPDLMSQIHSLNDSYENIPQILEDLKTLGIDACVGDISLMAEYLNKESGVYSLVEQAIALDSYVYAFKKGNKALKAEIERVLYILEKKGVLEKISRKWFGVDLLIFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L98</accession>
    <name>Q73L98_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972570.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679695.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1967"/>
    <dbReference type="EnsemblBacteria" id="AAS12481">
        <property type="protein sequence ID" value="AAS12481"/>
        <property type="gene ID" value="TDE_1967"/>
    </dbReference>
    <dbReference type="GeneID" id="2741530"/>
    <dbReference type="KEGG" id="tde:TDE_1967"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1859"/>
    <dbReference type="eggNOG" id="COG1302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056712_0_0_12"/>
    <dbReference type="OMA" id="RMIDKIT"/>
    <dbReference type="OrthoDB" id="1010640at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="298" mass="34015" checksum="47AAEDCAB076A098" modified="2004-07-05" version="1">MIDFKKILKKISWKIKGVSVYALVGESGTGKSFRAQLLAEKYGIKLIIDDGLLIYNDKIIAGQSAKREKTFLAAVKVALFDDKKHRDGVAKALQSHSFKKILILGTSEKMVNKIAARLQIPQPQKIIKIEDIASREEIETAMRSRRVEGKHVIPVPSIEVQRTYPQIFYDKIRLFFKNKKTPFVGTEQSKLFEKSVVRPEFSKVGTVEISESALTQMVFNCIEEYDKEVVIKKLNIKKEEGGYRLDLTVDIPFGTQLTGKINQLQKYIIEQIERYTGILIIQINVIIDKIINREDSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LG7</accession>
    <name>Q73LG7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">purN</name>
        <name evidence="4" type="ordered locus">TDE_1897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972500.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679594.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1897"/>
    <dbReference type="EnsemblBacteria" id="AAS12411">
        <property type="protein sequence ID" value="AAS12411"/>
        <property type="gene ID" value="TDE_1897"/>
    </dbReference>
    <dbReference type="GeneID" id="2739126"/>
    <dbReference type="KEGG" id="tde:TDE_1897"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1796"/>
    <dbReference type="eggNOG" id="COG0299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_0_1_12"/>
    <dbReference type="OMA" id="TGITIHY"/>
    <dbReference type="OrthoDB" id="1815747at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="3"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="13"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="2">
        <location>
            <begin position="91"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="194" mass="21878" checksum="0F145A21A8B6DB07" modified="2004-07-05" version="1">MKKKLAVLVSGNGSNLQAVIDGIKNGSIDYKIEAVVSNKKEAFALSRAEREGIKTIYLPFKKGSSRNEYDALLAEKVKEFKPDYVLLLGWMRILTDSFIATFKDRLINLHPALPGTFPGTEAIERQYEAFMKGEISRCGIMTHFVPDEGVDSGPVIFTEEVPVFQGDRLEDFEKRVHEAEHRLVIKTLKFLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LK8</accession>
    <name>Q73LK8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972458.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669612.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1854"/>
    <dbReference type="EnsemblBacteria" id="AAS12369">
        <property type="protein sequence ID" value="AAS12369"/>
        <property type="gene ID" value="TDE_1854"/>
    </dbReference>
    <dbReference type="GeneID" id="2740043"/>
    <dbReference type="KEGG" id="tde:TDE_1854"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1759"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_4_1_12"/>
    <dbReference type="OMA" id="SHNWIRK"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="107" mass="12485" checksum="DE4C993DD831F934" modified="2004-07-05" version="1">MSAFEKLRKNGINISEKDIKIIAAKYSIKEISVFGSSIRDDFDTDSDIDLLIEFYNSETISLYDIIDIQEYFEKITQRPVDIVEPEGLRNPYRRENILKTKEILYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LL9</accession>
    <name>Q73LL9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972447.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681206.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1843"/>
    <dbReference type="EnsemblBacteria" id="AAS12358">
        <property type="protein sequence ID" value="AAS12358"/>
        <property type="gene ID" value="TDE_1843"/>
    </dbReference>
    <dbReference type="GeneID" id="2740505"/>
    <dbReference type="KEGG" id="tde:TDE_1843"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1749"/>
    <dbReference type="eggNOG" id="ENOG5030YGM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1038036_0_0_12"/>
    <dbReference type="OrthoDB" id="1702172at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="268" mass="32668" checksum="C7625F6419F97FE9" modified="2004-07-05" version="1">MEENELIQKVKEYTYYLTDEYLEEVCKDLLQIKDINLFFEKCYENDAIHEWKSPCSFICDSVTHSHKYRELILKKYENDCIYKFCEKMLFDSSYTRRREALIIICDTLNIHRIKCKKLLEEYFLFVIEKDPLLLYDYIMEFTWLYAYEIRIRKNLYSKILNLNNEFANLTLLEYLDSLVVPFFSRDGLLKYKILSKLTRDKSRCVNSFAEKIKKNMLIKNYNKHIETKTYILGNAKLEFINIMFMNKTETYNKDDFINFYLNYVKENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LN3</accession>
    <name>Q73LN3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972433.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002683308.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1829"/>
    <dbReference type="EnsemblBacteria" id="AAS12344">
        <property type="protein sequence ID" value="AAS12344"/>
        <property type="gene ID" value="TDE_1829"/>
    </dbReference>
    <dbReference type="GeneID" id="2740491"/>
    <dbReference type="KEGG" id="tde:TDE_1829"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1735"/>
    <dbReference type="eggNOG" id="COG3577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643941_0_0_12"/>
    <dbReference type="OrthoDB" id="550720at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284590" evidence="1">
        <location>
            <begin position="28"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="426" mass="47543" checksum="654E3F17D5EC6A6C" modified="2004-07-05" version="1">MKQNQCKLIKMLSASLIFFCFFSGIFAQNEAECEKAVQAVAEACNEKSVTNVLPYLAEDFSIAGQSGNRAKAILQQLLAGVGTVISYEKTESFMEDGKLILKYSIEYSQVGKKESVFIFNKDNLIVEAELMKIKVKTLSSEERTIEYNTNKITSIPFIFAGNLPLVDVLLEGESRLFLLDSGAPFSILNSKYIEGLNTGTKKLGSFQDVSGNVSSPNMDITNVKELEFAGSKIKNQKIVVLDMTRLEQSLKTDGIYGLIGYDMLKEYDVFLDYQKKQLTLIRPDSYDSFIKANTLKVDSKIPCKMAGHIPAIEVSIGNKIYKLGLDTGAEFNLLDSFYFNELEPSLTNKEKTELSGAGGIKQEIYQAELKTMKIGGKTYKNVKTVFSDISHLRKKPDSYDGLLGYPFFSAQPTLISYKRGEIILFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LR9</accession>
    <name>Q73LR9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, carbon-nitrogen family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972397.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957047.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1793"/>
    <dbReference type="EnsemblBacteria" id="AAS12308">
        <property type="protein sequence ID" value="AAS12308"/>
        <property type="gene ID" value="TDE_1793"/>
    </dbReference>
    <dbReference type="GeneID" id="2741237"/>
    <dbReference type="KEGG" id="tde:TDE_1793"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1706"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_4_12"/>
    <dbReference type="OMA" id="IPNAIGY"/>
    <dbReference type="OrthoDB" id="1583074at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="295" mass="33435" checksum="6242AADCC9FBE010" modified="2004-07-05" version="1">MSKIIIALLQLTPGNSLVENMYIGIAACRKAKNMGADIALFPEMWSIGYEIPKSVNELKSKAISKNDAFIHSFSDLAKELQMAIGITFLEKYEPLPRNSICLFDRFGKELYTYAKVHTCIFGDEKNLMPGNDFYVSELDTERGCVKIGSMICYDREFPESARILMLKGAEILLVPNACPMEINRISQLRARAFENMVGIATVNYPKGKPDCNGHSTAFDGIAYEIDEPYSRDTLIIEAGEEEGIYIATFNIEELRKYRSREVHGNAYRQPTKYEILLSEEKQEPFIRKDYGKSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LT0</accession>
    <name>Q73LT0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972386.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1782"/>
    <dbReference type="EnsemblBacteria" id="AAS12297">
        <property type="protein sequence ID" value="AAS12297"/>
        <property type="gene ID" value="TDE_1782"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1782"/>
    <dbReference type="HOGENOM" id="CLU_3349896_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="37" mass="4074" checksum="6AD83D27FF89B8FC" modified="2004-07-05" version="1">MFCHESCLDGRLRLPFLCNFRANFAAAMRIGKAANAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LV4</accession>
    <name>Q73LV4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972362.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679496.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1758"/>
    <dbReference type="EnsemblBacteria" id="AAS12273">
        <property type="protein sequence ID" value="AAS12273"/>
        <property type="gene ID" value="TDE_1758"/>
    </dbReference>
    <dbReference type="GeneID" id="2740603"/>
    <dbReference type="KEGG" id="tde:TDE_1758"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1680"/>
    <dbReference type="HOGENOM" id="CLU_1371680_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="194" mass="22894" checksum="A04C4571D372868A" modified="2004-07-05" version="1">MLKLQFKKLYFLLLILTLSLILIIIFTSIYLNNNNKAESYFIDRIQDFEVYFVNNNYIFVSFSGNGSFLYGGIIHKDKFKNEEDLYFKNIKNRLNSEDSYKFKLNNYPDNAVIYIGNYDSDKNIEVFFYEFMGISIELPIEITPLGKVQKQGVFNNVFLIFSIIMNMFFSYIFVFICCILVLAVLMTHMGIKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LW2</accession>
    <name>Q73LW2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972354.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679471.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1750"/>
    <dbReference type="EnsemblBacteria" id="AAS12265">
        <property type="protein sequence ID" value="AAS12265"/>
        <property type="gene ID" value="TDE_1750"/>
    </dbReference>
    <dbReference type="GeneID" id="2740595"/>
    <dbReference type="KEGG" id="tde:TDE_1750"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1673"/>
    <dbReference type="HOGENOM" id="CLU_1895264_0_0_12"/>
    <dbReference type="OrthoDB" id="2065603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16332">
        <property type="entry name" value="Prp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007422">
        <property type="entry name" value="Peptidase_Prp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036764">
        <property type="entry name" value="Peptidase_Prp_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04327">
        <property type="entry name" value="Peptidase_Prp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118010">
        <property type="entry name" value="SSF118010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="128" mass="13631" checksum="845FDE23D3237B4F" modified="2004-07-05" version="1">MVKIRLLSNAENCFSAFESSGHAGGNYAGSDHADFGDNDGKPEKGGNIVCAAVTILLKTAVLSLSSAQKESSSLKAEIRADNPGYLSAKITAFSGDDKPRLQYLLEFLTIGLMAIEAEYPDCLDLQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LY5</accession>
    <name>Q73LY5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972331.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669420.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1727"/>
    <dbReference type="EnsemblBacteria" id="AAS12242">
        <property type="protein sequence ID" value="AAS12242"/>
        <property type="gene ID" value="TDE_1727"/>
    </dbReference>
    <dbReference type="GeneID" id="2739185"/>
    <dbReference type="KEGG" id="tde:TDE_1727"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1651"/>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100275_2_1_12"/>
    <dbReference type="OMA" id="PVEYYLA"/>
    <dbReference type="OrthoDB" id="1430018at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="138" mass="14925" checksum="A60A3E8DF185E8DC" modified="2004-07-05" version="1">MAKEFRTKAEIDLGEGFKVECEASGKKIIADEPLSFGGTDLGMNPIELLLSGLGACKCVTSKVIAKKKGLKLDYLAVECIGFFRPGTLGLSDIETIYHIKSDASDEELEKFMALVDDSCPVHATIKNPAPIAHKLIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M04</accession>
    <name>Q73M04_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972311.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669387.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1707"/>
    <dbReference type="EnsemblBacteria" id="AAS12222">
        <property type="protein sequence ID" value="AAS12222"/>
        <property type="gene ID" value="TDE_1707"/>
    </dbReference>
    <dbReference type="GeneID" id="2740879"/>
    <dbReference type="KEGG" id="tde:TDE_1707"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1632"/>
    <dbReference type="eggNOG" id="COG1664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072799_4_3_12"/>
    <dbReference type="OMA" id="TDVVICD"/>
    <dbReference type="OrthoDB" id="1968497at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="138" mass="15174" checksum="95B1B140700B0FE2" modified="2004-07-05" version="1">MKRNNKYKEKNVTVLGKETVFDGVMKFSETLQIEGKFIGAIDSQGSLYISKNADCRVQYIKAASIVVEGVIVGSLSAADKVDLKSGSSVKGDITAGRLRIADKVSFEGSVKMIKNNSFPEKNFFSIKSDQLKEQLSRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M14</accession>
    <name>GPMA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="1">BPG-dependent PGAM</shortName>
            <shortName evidence="1">PGAM</shortName>
            <shortName evidence="1">Phosphoglyceromutase</shortName>
            <shortName evidence="1">dPGM</shortName>
            <ecNumber evidence="1">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmA</name>
        <name type="synonym">gpm</name>
        <name type="ordered locus">TDE_1697</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972301.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670958.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M14"/>
    <dbReference type="SMR" id="Q73M14"/>
    <dbReference type="STRING" id="243275.TDE_1697"/>
    <dbReference type="EnsemblBacteria" id="AAS12212">
        <property type="protein sequence ID" value="AAS12212"/>
        <property type="gene ID" value="TDE_1697"/>
    </dbReference>
    <dbReference type="GeneID" id="2740869"/>
    <dbReference type="KEGG" id="tde:TDE_1697"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1623"/>
    <dbReference type="eggNOG" id="COG0588">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_1_1_12"/>
    <dbReference type="OMA" id="RMLPYWY"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000179933" description="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <sequence length="247" mass="28592" checksum="C8E88E215339B654" modified="2004-07-05" version="1">MRLVLVRHGESEWNKLNLFTGWTDVDLSEKGVEEAKEGGTYLKKEGFDFDICYTSYLKRAIHTLNYILSQMDREWLPVIKTWKLNERHYGGLQGLNKAETAEKYGEDQVKIWRRSFDIAPPVLEEGDKRCPYLQEQYRGIEKSELPLTESLKDTIARAVPFFEKTIKPQMLEGKRILITAHGNSLRALVKYFENLSDEEIISVNIPTGVPLVYEFDKNFKVLSKRYLGDQEKINAKINAVANQGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M50</accession>
    <name>Q73M50_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine Rich Repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972265.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679357.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1660"/>
    <dbReference type="EnsemblBacteria" id="AAS12176">
        <property type="protein sequence ID" value="AAS12176"/>
        <property type="gene ID" value="TDE_1660"/>
    </dbReference>
    <dbReference type="GeneID" id="2739001"/>
    <dbReference type="KEGG" id="tde:TDE_1660"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1587"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_250231_0_0_12"/>
    <dbReference type="OrthoDB" id="956253at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1518" mass="164372" checksum="E7DF471A9F9A4F97" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M52</accession>
    <name>Q73M52_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Basic membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972263.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669285.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73M52"/>
    <dbReference type="STRING" id="243275.TDE_1658"/>
    <dbReference type="EnsemblBacteria" id="AAS12174">
        <property type="protein sequence ID" value="AAS12174"/>
        <property type="gene ID" value="TDE_1658"/>
    </dbReference>
    <dbReference type="GeneID" id="2738999"/>
    <dbReference type="KEGG" id="tde:TDE_1658"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1585"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034646_2_0_12"/>
    <dbReference type="OMA" id="KKEFAIN"/>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285975" evidence="1">
        <location>
            <begin position="21"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="358" mass="40422" checksum="9ABDE4CB9DEC397F" modified="2004-07-05" version="1">MKKNIFIAVMLVGFLGLLSAQNDLQVIAQVNLSKKEPITLGQLKKLVKFAESQGGNIATNDDKKLVLESLMRTKLLVQAAEKENIKISNSQVDNAFNDVLSQYVKYPITESEFAKLIKQKENISLDEFMKKQTGCTVEELKKIIKDNLIIQNYIASKHQAEIVKMATPTDAQIRSYYEMKKGELVRPDMVKMLFVAVKKEGKDKEEIDKINELHKKVKKNIKEIANIKKNAEAGNYVAQEGYIPKTAEGAQLLNATPEALMEIFSKDVNYIFDIQDRVDSRQFFVITEKLNAKILTLSDVPDPSSTVTLYDQIKALLSQGLALNAIQSIIQTTYEGLRTDDNCKILKSDAELDKLLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MA3</accession>
    <name>Q73MA3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972212.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679289.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1606"/>
    <dbReference type="EnsemblBacteria" id="AAS12123">
        <property type="protein sequence ID" value="AAS12123"/>
        <property type="gene ID" value="TDE_1606"/>
    </dbReference>
    <dbReference type="GeneID" id="2740847"/>
    <dbReference type="KEGG" id="tde:TDE_1606"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1535"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_6_0_12"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="225" mass="26112" checksum="A45144E12D1A543E" modified="2004-07-05" version="1">MGNGDFDLTHKKILECGKKIFKEKGFEKANLREICAQAGVTTGAFYGHFKDKEALFSELVQPVITDIEYHYSLLKQQSFTMYKKETVITKQTIESILDLKLKGAVGMVSYFFDNKDIFELLAFCSYGTKHEHFLDEIIEKEDENHLKILEMIHGKKKAAQVITKKGIHLLNHAYLYALSEVAVHCETKEEAEHNAYLIADFFNEGWKKMRTGQFNYELKLIYNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MB3</accession>
    <name>Q73MB3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972202.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669155.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1596"/>
    <dbReference type="EnsemblBacteria" id="AAS12113">
        <property type="protein sequence ID" value="AAS12113"/>
        <property type="gene ID" value="TDE_1596"/>
    </dbReference>
    <dbReference type="GeneID" id="2739793"/>
    <dbReference type="KEGG" id="tde:TDE_1596"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1526"/>
    <dbReference type="eggNOG" id="ENOG502Z8PK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093450_5_0_12"/>
    <dbReference type="OrthoDB" id="1668819at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011733">
        <property type="entry name" value="CHP02185_IM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09605">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02185">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="193" mass="21657" checksum="9E747C94E62B5A58" modified="2004-07-05" version="1">MEGKRNFQIKDLIITALMVLCSQILYRILSFLFMSPYTMLLTMPIWAIIGAIAYFLVPAKTKNPWMILLFCILTSIIGFYPPYIISCIIGGVLAMLIARIKGIENYKGLTIGYILFCVLASFGGMYVPFLFYAEQTLNAYKEMFGAEYLETLTKLVSPTITVIMLIITALCGCIGALISKKLLKKHFEKAGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MB9</accession>
    <name>Q73MB9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, DegT/DnrJ/EryC1/StrS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972196.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679269.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1590"/>
    <dbReference type="EnsemblBacteria" id="AAS12107">
        <property type="protein sequence ID" value="AAS12107"/>
        <property type="gene ID" value="TDE_1590"/>
    </dbReference>
    <dbReference type="GeneID" id="2739787"/>
    <dbReference type="KEGG" id="tde:TDE_1590"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1520"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_2_0_12"/>
    <dbReference type="OMA" id="GVAFREY"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="341" mass="37651" checksum="1555089075D3613A" modified="2004-07-05" version="1">MKIPVYSSTIRRSEMDAVLTCMVEEKIGPGEMNQKLIKQVCETFQTAGAAAFRSPAIALNYALKALNLENEALVIISSLAPSWQYVELNRQGYKPIVLDVEADSVFPSFESIENAVQAGGRVLVLHETLGFLPDMEKILSLNIPVIEDISQSAGAAYKEKYAGSMGVFSILGLEEKDILTGGGGAVLLAPERRNAIVLKKLYDESPLTDQLPDINASLAFVQLKQMAKNMEQRKEMHESYIRSLMQGKHKTIAQKEDTVNPVYSFPVILNSGVSDVQKYAAKKDIDIELAFKNSTVEYLKENQESFINASSLLLRCVLFPLYPRLGAKKSSEIARVLATLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MD0</accession>
    <name>Q73MD0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibronectin/fibrinogen-binding protein, internal deletion</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972185.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679249.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1579"/>
    <dbReference type="EnsemblBacteria" id="AAS12096">
        <property type="protein sequence ID" value="AAS12096"/>
        <property type="gene ID" value="TDE_1579"/>
    </dbReference>
    <dbReference type="GeneID" id="2739776"/>
    <dbReference type="KEGG" id="tde:TDE_1579"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1508"/>
    <dbReference type="eggNOG" id="COG1293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022481_2_0_12"/>
    <dbReference type="OMA" id="ANDLWMH"/>
    <dbReference type="OrthoDB" id="713667at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="2">
        <location>
            <begin position="349"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="471" mass="54001" checksum="8F87BD7AAED3921B" modified="2004-07-05" version="1">MSLNNKEIDLILEELKLEGFFIQKIIQPSYTALVFYLYKDKPLTLFISLDAGACRLHSTRKKIPKFDKPMRFMELLKSRIKGGKILKAEQLNEDRIIRLHIASGAGDFFLYLRLWSGAANIVLTDENNLIIDAFYRRPKKGEISGGTWLTPEPQKIKKQDYCVREYDKTKTFNEAVEEWYINNAPKVSKEALLDEAENLYGTKILKIEKALLKLKAKREEFLNAQSLKNAGDLLFSNLHLIKKGMKFIELEDYTKNGAKITITLEPLKTPQENANLYYEKYKKAVSGLEALEEDIISAEKEIEKLKEKIEKIKTEENPYLIQKILQKEKIPVQQKAKNTKSAPGLKFFSEGWTILVGRTAAENDELLRHFVKGTDLWLHTRDYAGGYVFIKARAGKSIPLPVLIKAGNLAVFYSKARKNGQADLYTTQVKYLRRAKNAPKGTVLPTHEKNLSIKLDEKILKQLEEEKISAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MG3</accession>
    <name>Q73MG3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyl transferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972151.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679200.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1545"/>
    <dbReference type="EnsemblBacteria" id="AAS12062">
        <property type="protein sequence ID" value="AAS12062"/>
        <property type="gene ID" value="TDE_1545"/>
    </dbReference>
    <dbReference type="GeneID" id="2740907"/>
    <dbReference type="KEGG" id="tde:TDE_1545"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1481"/>
    <dbReference type="eggNOG" id="COG2236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080904_1_2_12"/>
    <dbReference type="OMA" id="QEYFDFK"/>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="200" mass="23423" checksum="66F5CAA6F971F0C0" modified="2004-07-05" version="1">MKEFLNYNTVRDNGFILARKMYDEGYVPDVIYASMRGGAYLANVISEFFKIAYKDEKKILYSTVVAHSYSGVHNNSEIVLDGWTLHPSKLPAEALVLLVDDIFDSGATINYLVDELIKQGLKRENIKIAVHDYKYFHDKKEQYEHHPDYWCRKHDIYTEKDNLWIHYMSHELVGLSNKELEENYYSKNPALKDVFKGIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MH3</accession>
    <name>Q73MH3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972141.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679190.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1535"/>
    <dbReference type="EnsemblBacteria" id="AAS12052">
        <property type="protein sequence ID" value="AAS12052"/>
        <property type="gene ID" value="TDE_1535"/>
    </dbReference>
    <dbReference type="GeneID" id="2740897"/>
    <dbReference type="KEGG" id="tde:TDE_1535"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1472"/>
    <dbReference type="eggNOG" id="COG1692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068238_0_0_12"/>
    <dbReference type="OMA" id="KSRVSAC"/>
    <dbReference type="OrthoDB" id="1127353at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005235">
        <property type="entry name" value="YmdB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36303">
        <property type="entry name" value="PTHR36303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13277">
        <property type="entry name" value="YmdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004789">
        <property type="entry name" value="DR1281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="267" mass="29325" checksum="0F14B13A82CE9FE2" modified="2004-07-05" version="1">MNILYIAEITGKAGVWLVKTQLSNLKEKYKADFVIANANSATGSGGLGKQHAVYLKKLGIDCITSGDLIFQKKDLVDDLPKTPHVLRPFNLPSESPGNGWKIFNLKPNKKIAVVSVIGRIGHHKIMAENPFTETEKLVSRLKEEADIIFVDFSSFATAEKQALGFLLSGKVSALIGSGTRVQTADECILENKTAYITDAGRTGSLNSVGGYAIEDKIREYRTCLPDFGKDAWARPVLQGLFIKTDDEGNAIEIKRIFEESELCKDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MK0</accession>
    <name>Q73MK0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972114.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679162.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1508"/>
    <dbReference type="EnsemblBacteria" id="AAS12025">
        <property type="protein sequence ID" value="AAS12025"/>
        <property type="gene ID" value="TDE_1508"/>
    </dbReference>
    <dbReference type="GeneID" id="2739714"/>
    <dbReference type="KEGG" id="tde:TDE_1508"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1447"/>
    <dbReference type="eggNOG" id="ENOG503324G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134846_2_0_12"/>
    <dbReference type="OrthoDB" id="1669251at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025531">
        <property type="entry name" value="DUF4418"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14387">
        <property type="entry name" value="DUF4418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="131" mass="14410" checksum="595A66F1599FA3E1" modified="2004-07-05" version="1">MKRYIFSALIIIIGLLVLFAPFGFAHVCHPKADGSFMKCHWMGEAVRLLGGLIALSGLAFFICKKSRFGISVYNIGTGVSLILLETLVIGTCKHPNMSCNVYTKPIVILLAIALIAVSLVYVFLSRKEKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MM6</accession>
    <name>Q73MM6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase, M24 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972088.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679150.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1482"/>
    <dbReference type="EnsemblBacteria" id="AAS11999">
        <property type="protein sequence ID" value="AAS11999"/>
        <property type="gene ID" value="TDE_1482"/>
    </dbReference>
    <dbReference type="GeneID" id="2739883"/>
    <dbReference type="KEGG" id="tde:TDE_1482"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1421"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011781_2_4_12"/>
    <dbReference type="OMA" id="YRPGKWG"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="3">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="307"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24_C" evidence="4">
        <location>
            <begin position="525"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="585" mass="65579" checksum="0B450EF017257EB3" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MV6</accession>
    <name>Q73MV6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DedA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the DedA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972007.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668779.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1401"/>
    <dbReference type="EnsemblBacteria" id="AAS11918">
        <property type="protein sequence ID" value="AAS11918"/>
        <property type="gene ID" value="TDE_1401"/>
    </dbReference>
    <dbReference type="GeneID" id="2741268"/>
    <dbReference type="KEGG" id="tde:TDE_1401"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1343"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_4_1_12"/>
    <dbReference type="OMA" id="MHIILEF"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032818">
        <property type="entry name" value="DedA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30353">
        <property type="entry name" value="PTHR30353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="207" mass="23188" checksum="8B869A50E145D79C" modified="2004-07-05" version="1">MLTAFLNWIGNYITYFPLVAFIGLLLGGFNIPISEDILVAMSAIFSQGEKASIPNFLAALYAGAFISDCMVYGWGRLIAKGSISTGLFSKIITKENTYRLLKALQKHGIFTFIICRFIPFGVRNVVSMTSGFVKYPFYKFFIYDLIAAICNITVLYSLVYFFGRKGGDFMKIFGIVMFVLFLAAGAYLVTSGKLFQFADKKLDQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N28</accession>
    <name>Q73N28_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971934.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668656.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1328"/>
    <dbReference type="EnsemblBacteria" id="AAS11845">
        <property type="protein sequence ID" value="AAS11845"/>
        <property type="gene ID" value="TDE_1328"/>
    </dbReference>
    <dbReference type="GeneID" id="2741062"/>
    <dbReference type="KEGG" id="tde:TDE_1328"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1276"/>
    <dbReference type="HOGENOM" id="CLU_142314_0_0_12"/>
    <dbReference type="OrthoDB" id="2006757at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="146" mass="16484" checksum="3193A1279CCAE6B7" modified="2004-07-05" version="1">MKRISTILIYLGIGAILFAQSAEKVDEILASKTLTIGQACYLVGTSTGEVDDKSSYETAFNKFKGLKMFENKKHDEPIRFDEFSNLALQYSSIEHGLWYGIAKNPHYAFRQLKTMKLIPHKTVPSSHITPFTAINLLAKIMPKEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N44</accession>
    <name>Q73N44_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF853 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971918.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678845.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1312"/>
    <dbReference type="EnsemblBacteria" id="AAS11829">
        <property type="protein sequence ID" value="AAS11829"/>
        <property type="gene ID" value="TDE_1312"/>
    </dbReference>
    <dbReference type="GeneID" id="2739570"/>
    <dbReference type="KEGG" id="tde:TDE_1312"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1261"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028164_1_1_12"/>
    <dbReference type="OMA" id="TTEYGNI"/>
    <dbReference type="OrthoDB" id="600220at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033186">
        <property type="entry name" value="HerA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05872">
        <property type="entry name" value="DUF853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF853" evidence="2">
        <location>
            <begin position="12"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="431"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="515" mass="57344" checksum="6B63DF475CA64EFE" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N87</accession>
    <name>Q73N87_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II restriction endonuclease TdeI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tdeIR</name>
        <name evidence="2" type="ordered locus">TDE_1268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971875.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678771.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1268"/>
    <dbReference type="REBASE" id="6310">
        <property type="entry name" value="TdeI"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11786">
        <property type="protein sequence ID" value="AAS11786"/>
        <property type="gene ID" value="TDE_1268"/>
    </dbReference>
    <dbReference type="GeneID" id="2740561"/>
    <dbReference type="KEGG" id="tde:TDE_1268"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1219"/>
    <dbReference type="eggNOG" id="ENOG502Z8N2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095681_0_0_12"/>
    <dbReference type="OMA" id="HHIMCSI"/>
    <dbReference type="OrthoDB" id="711070at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010324">
        <property type="entry name" value="DRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041368">
        <property type="entry name" value="DRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043025">
        <property type="entry name" value="DRP_PD-(D/E)XK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06044">
        <property type="entry name" value="DpnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17726">
        <property type="entry name" value="DpnI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DpnI_C" evidence="1">
        <location>
            <begin position="186"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="256" mass="30090" checksum="0459D8012013277F" modified="2004-07-05" version="1">MIYRFDISLIKKYHSKSQIVRVLTEDWVLRNFNCPICGKLKIEAYPNNYPAGDFFCKNCKSDFELKSKESISGKLPNIITDGAYKTMIERITSYRNPNFLFLTYKDYEVSNFILIPNHFFTPSIILKRKPLSNTARRAGWIGCNIDISKIPDAGKIFIIKDQIETDSKEIINKYAKIKSLKKTNIESRGWLLDIIACIEKINTEEFSLNQIYAFENELKLKHPENNFIKDKIRQQLQYLRDKGFVKFLERGKYKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N97</accession>
    <name>Q73N97_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GrdX protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971865.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668535.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1258"/>
    <dbReference type="EnsemblBacteria" id="AAS11776">
        <property type="protein sequence ID" value="AAS11776"/>
        <property type="gene ID" value="TDE_1258"/>
    </dbReference>
    <dbReference type="GeneID" id="2741434"/>
    <dbReference type="KEGG" id="tde:TDE_1258"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1210"/>
    <dbReference type="eggNOG" id="ENOG5032Y6H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132073_1_0_12"/>
    <dbReference type="OrthoDB" id="2037478at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="131" mass="15458" checksum="32D75477402B866C" modified="2004-07-05" version="1">MQKDSQTNQRLIITNNPKVKAFYEEDRTGLKNRYALKFLDSRDEVFKTVRDLIHSNWKLLNHAMAGNIPLHKHPYRSMALEQQEKLDTNSLILWESAMERVKRGKTPPYPDDVLEDFQELDYNLFSGSVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N98</accession>
    <name>Q73N98_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971864.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677773.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1257"/>
    <dbReference type="EnsemblBacteria" id="AAS11775">
        <property type="protein sequence ID" value="AAS11775"/>
        <property type="gene ID" value="TDE_1257"/>
    </dbReference>
    <dbReference type="GeneID" id="2741433"/>
    <dbReference type="KEGG" id="tde:TDE_1257"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1209"/>
    <dbReference type="eggNOG" id="ENOG5033YSU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086052_0_0_12"/>
    <dbReference type="OMA" id="CNEYEEA"/>
    <dbReference type="OrthoDB" id="1002609at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="270" mass="31533" checksum="69BB6E343336500E" modified="2004-07-05" version="1">MKLKVLFVIFNIVLILLLFTVFFLPLFYADGSFMREFWKANWFFGPVFLILILFVNIMFLKNRLLIKYIESEDWSSLASLLEKKIYTKKRITYKSSLLLAESLLLLGDFTSMNKFCDFLKDNKPKYISKLGPKFAAAKMISGNYQDVFEFSSSLPVLKTTASEWIVFYSALSLQMMKNYEKSAALFTKVSDSAKNPLIKCLSTYFVVNVLQTYSQLTEEEIKAKALLLHSRINKNYTYESWKAYTESEKQEIHVMILTKIIDDVTSWLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NC1</accession>
    <name>Q73NC1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971841.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678730.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1234"/>
    <dbReference type="EnsemblBacteria" id="AAS11752">
        <property type="protein sequence ID" value="AAS11752"/>
        <property type="gene ID" value="TDE_1234"/>
    </dbReference>
    <dbReference type="GeneID" id="2741176"/>
    <dbReference type="KEGG" id="tde:TDE_1234"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1188"/>
    <dbReference type="eggNOG" id="ENOG50348TB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032724_0_0_12"/>
    <dbReference type="OMA" id="NPAMIFH"/>
    <dbReference type="OrthoDB" id="776762at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038636">
        <property type="entry name" value="Wzi_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004286006" evidence="1">
        <location>
            <begin position="27"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="561" mass="63615" checksum="FA050636F49B7A11" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ND6</accession>
    <name>Q73ND6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar FliJ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_1219</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliJ family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971826.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678708.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1219"/>
    <dbReference type="EnsemblBacteria" id="AAS11737">
        <property type="protein sequence ID" value="AAS11737"/>
        <property type="gene ID" value="TDE_1219"/>
    </dbReference>
    <dbReference type="GeneID" id="2740113"/>
    <dbReference type="KEGG" id="tde:TDE_1219"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1174"/>
    <dbReference type="eggNOG" id="COG2882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139638_0_0_12"/>
    <dbReference type="OMA" id="KEWMKED"/>
    <dbReference type="OrthoDB" id="2086136at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012823">
        <property type="entry name" value="Flagell_FliJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02050">
        <property type="entry name" value="FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02473">
        <property type="entry name" value="flagell_FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="154" mass="18335" checksum="A05C6867196AE00B" modified="2004-07-05" version="1">MKRFEFRLEKLLNLREFYEHQAEIDLAHAIAHKDYIDLQLKQIAKLKVKTGTEFNPETDKIDITDLHNAQNYIILLDKKKDELLEKLVLAEQIIEEKRKIYIEAASKRKVISKLKEKKRALWEKENIKAEETYIDDIVTYKFGQNKTIAVNNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NG4</accession>
    <name>Q73NG4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="2">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pntB</name>
        <name evidence="11" type="ordered locus">TDE_1188</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+)(in) + NAD(+) + NADPH = H(+)(out) + NADH + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971796.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956923.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1188"/>
    <dbReference type="EnsemblBacteria" id="AAS11707">
        <property type="protein sequence ID" value="AAS11707"/>
        <property type="gene ID" value="TDE_1188"/>
    </dbReference>
    <dbReference type="GeneID" id="2741149"/>
    <dbReference type="KEGG" id="tde:TDE_1188"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1144"/>
    <dbReference type="eggNOG" id="COG1282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007866_2_1_12"/>
    <dbReference type="OMA" id="FEMEAIN"/>
    <dbReference type="OrthoDB" id="218925at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB" evidence="10">
        <location>
            <begin position="10"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="PNTB" evidence="10">
        <location>
            <begin position="497"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="484"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="682" mass="71315" checksum="6A0FC2D4E0D7DA50" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NJ2</accession>
    <name>Q73NJ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971768.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956906.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1160"/>
    <dbReference type="EnsemblBacteria" id="AAS11649">
        <property type="protein sequence ID" value="AAS11649"/>
        <property type="gene ID" value="TDE_1160"/>
    </dbReference>
    <dbReference type="GeneID" id="2741492"/>
    <dbReference type="KEGG" id="tde:TDE_1160"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1119"/>
    <dbReference type="HOGENOM" id="CLU_576092_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="474" mass="54279" checksum="DA0F804BFA681BC6" modified="2004-07-05" version="1">MADGKTLTWRKFPRDTITNPALLFIAKKLPKERQHQVFTLFVALYCNADDDGVVDLSDLAVFSYTCIMSEDDLVDLLYRFLDRHIIEEITISGVPAYRIAGWLDPYPGRMTAAEKQAAYRSRIAEKKQPEKRSFLGSKGRQAPPAENPIDTPKPDVSDDTDAVYDEAGELSDDEILALFLRLEKEDEMEAPIKIVEPPESAAAETPKSVTERYPDVTGVTGEKNEVTAENCSVTQRYPTPLKTEETDRRDRERQTEGEEIETEEREMRDRETERETDRGEIDIEDTEQKKRKGRKRKDKTHTDRAENPARAPTGEILKEREAEEKETEEPPEREREPAPELAAVAEDTKKTKREAERRRACFKILWTFFNDKNPMGFVDEEAELLACAELAKMIVKLEDEKNTAEIIACQFTNSFNRLLNKGGYFENMPCTPIMLLKPGNYSKVFYSVSKILHPKDQGGMHWAAELKKVMDNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NK4</accession>
    <name>Q73NK4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1148</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971756.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956895.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1148"/>
    <dbReference type="EnsemblBacteria" id="AAS11637">
        <property type="protein sequence ID" value="AAS11637"/>
        <property type="gene ID" value="TDE_1148"/>
    </dbReference>
    <dbReference type="GeneID" id="2741480"/>
    <dbReference type="KEGG" id="tde:TDE_1148"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1107"/>
    <dbReference type="HOGENOM" id="CLU_1969544_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="127" mass="14255" checksum="77BB24021158B748" modified="2004-07-05" version="1">MINLYLDKRLELSSDQAITTTAESQNAIDFGTDSCSADGKRIDFRIKEKFQGGTSLKFILQDSANGTSFDDKLTSTTFNTAVLVESQKEPFYSLVIPKGLRRYIRVKYDVQGTFTKGKIHAILNTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NL9</accession>
    <name>Q73NL9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971741.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956880.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1133"/>
    <dbReference type="TCDB" id="1.E.49.1.1">
        <property type="family name" value="the putative treponema 4 tms holin (tre4hol) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11622">
        <property type="protein sequence ID" value="AAS11622"/>
        <property type="gene ID" value="TDE_1133"/>
    </dbReference>
    <dbReference type="GeneID" id="2739992"/>
    <dbReference type="KEGG" id="tde:TDE_1133"/>
    <dbReference type="eggNOG" id="ENOG5032AV1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2132415_0_0_12"/>
    <dbReference type="OrthoDB" id="2215413at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="101" mass="11067" checksum="EA5063E93BEB1174" modified="2004-07-05" version="1">MKNKFMFFVIVGLVILSIFIVNYGQSITTDCIGAVIGLAGGALAVFDTVKYSRRKIALVPLWIGILILIVTGFIQFKGVIILAAFGFAALGLYIYFRLTEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-03-08" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NM0</accession>
    <name>AROC_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chorismate synthase</fullName>
            <shortName evidence="1">CS</shortName>
            <ecNumber evidence="1">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroC</name>
        <name type="ordered locus">TDE_1132</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="1">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971740.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682425.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NM0"/>
    <dbReference type="SMR" id="Q73NM0"/>
    <dbReference type="STRING" id="243275.TDE_1132"/>
    <dbReference type="EnsemblBacteria" id="AAS11621">
        <property type="protein sequence ID" value="AAS11621"/>
        <property type="gene ID" value="TDE_1132"/>
    </dbReference>
    <dbReference type="GeneID" id="2739991"/>
    <dbReference type="KEGG" id="tde:TDE_1132"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1092"/>
    <dbReference type="eggNOG" id="COG0082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_0_0_12"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="981870at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000405973" description="Chorismate synthase">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="302"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <sequence length="361" mass="38655" checksum="CE22B60A39A28C28" modified="2004-07-05" version="1">MGANSFGRFFTLTTFGESRSAGVGAVIDGCPAGIPLCADDIQKELNRRKPGSSGPFSTKRNEDDICEILSGVFEGRTLGSPIAVLVRNKETSSKDYENLKDVYRPGHADYSYDLKYGHRDYRGGGRSSGRETIGRLIGGAVAKKMLEAFAIKDGKKTIEVQVRAEEIAGIKTSLPLKEDEALPEPIFEKLSALASNGDSAGCILSCSVLNVSEGLGSPVFGKLDAVLSQALMSIGAVKGIEIGGGFYSASITGSENNDISKNFSGGILGGISCNMDYPLNLNHENGRKDENTCQIDFRIAVKPVPSIKMNQASFNKKGEKCMLSVGGNHDICLFPRIVPVVEAMCYLVLADAFLVSKIERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NS1</accession>
    <name>Q73NS1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971689.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682391.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1081"/>
    <dbReference type="EnsemblBacteria" id="AAS11570">
        <property type="protein sequence ID" value="AAS11570"/>
        <property type="gene ID" value="TDE_1081"/>
    </dbReference>
    <dbReference type="GeneID" id="2739093"/>
    <dbReference type="KEGG" id="tde:TDE_1081"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1041"/>
    <dbReference type="eggNOG" id="ENOG502ZNE8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104656_0_0_12"/>
    <dbReference type="OMA" id="PEPYTEN"/>
    <dbReference type="OrthoDB" id="2040023at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285865" evidence="3">
        <location>
            <begin position="25"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="169" mass="19187" checksum="2E487FE980B5C95E" modified="2004-07-05" version="1">MKHTKKIAFLIFFVSLFSVFPVYAEDTKVSKTPDPYGAEEFKQWQKDLRRFEIITFGALPFVSLLSFWAYDIGRSIAHKGDPAYNPWPLKDAKIAVKLTEKEQLGVFLTAVGISLGVAIIDITYRSIKRANAKKLEEKNEEPAILLIPIEENKSEETETSKTEESDDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NS7</accession>
    <name>Q73NS7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971683.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670599.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1075"/>
    <dbReference type="TCDB" id="3.A.1.5.47">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11564">
        <property type="protein sequence ID" value="AAS11564"/>
        <property type="gene ID" value="TDE_1075"/>
    </dbReference>
    <dbReference type="GeneID" id="2739087"/>
    <dbReference type="KEGG" id="tde:TDE_1075"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1035"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_12"/>
    <dbReference type="OMA" id="PYHTIGK"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="BRENDA" id="7.4.2.9">
        <property type="organism ID" value="6426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="325" mass="36460" checksum="180600052954883B" modified="2004-07-05" version="1">MENKEVVLDVKNLRLYYHTSAGIVKALDDVSFTLHAGETLGLVGESGCGKTTTGMALLKMPSPPGRVEENSQIIINGRDIVPLSDSEIRKNVRWQEISMVFQGAMNSLTPVYTIGKQMLETLREHKEMSDKEAQDLMEEYLGYVGLPPEVLNRYPHELSGGMKQRVVIASGLFLKPKLVILDEPTTALDVIVQAQIINLLKELKKKFKLSFIFITHDLSLEAEISDRICVMYAGKIAELGTNEQIYGKEPLHPYTQKLLQATPLLRKRVSELSYIPGTPPDLISPPKGCRFNPRCHCTMDKCFEVEPPLIEVEPGHQVACWRCVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NT6</accession>
    <name>Q73NT6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971674.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670564.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1066"/>
    <dbReference type="EnsemblBacteria" id="AAS11555">
        <property type="protein sequence ID" value="AAS11555"/>
        <property type="gene ID" value="TDE_1066"/>
    </dbReference>
    <dbReference type="GeneID" id="2740827"/>
    <dbReference type="KEGG" id="tde:TDE_1066"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1026"/>
    <dbReference type="eggNOG" id="ENOG5032177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2774764_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="69" mass="7915" checksum="1728475AB876DB79" modified="2004-07-05" version="1">MFFRDHDHSLKSKRRQAMEENEELNHLREEANLEKGDVPALIIAALTTLLPIAAVIVLAYYLISMFIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NU1</accession>
    <name>Q73NU1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein, HlyB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_1061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.1021"/>
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    </evidence>
    <sequence length="594" mass="68213" checksum="11CDC59BF40328B1" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NU2</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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        <source>
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        <source>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
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                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
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                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
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            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="entry name" value="DctM"/>
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        <property type="entry name" value="dctM"/>
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        </location>
    </feature>
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    </feature>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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        <location>
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    </feature>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="430"/>
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    <feature type="transmembrane region" description="Helical" evidence="3">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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    </feature>
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        <location>
            <begin position="203"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="AAS11508.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="615" mass="66195" checksum="D6AD2256848DB818" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NY3</accession>
    <name>Q73NY3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971626.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670484.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11507">
        <property type="protein sequence ID" value="AAS11507"/>
        <property type="gene ID" value="TDE_1018"/>
    </dbReference>
    <dbReference type="GeneID" id="2740998"/>
    <dbReference type="KEGG" id="tde:TDE_1018"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.979"/>
    <dbReference type="eggNOG" id="ENOG503017P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150098_0_0_12"/>
    <dbReference type="OMA" id="NIFTSTM"/>
    <dbReference type="OrthoDB" id="1962277at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="142" mass="15460" checksum="FB700014D1449AEE" modified="2004-07-05" version="1">MKRTVGLVVLQIALAFFLIVAGVLGLIRSTAGELGQTIALLDAVFRSQTITTIIIITLAVAELIAGVFLIVEFFSGEIRLTNVILLVFMILWIVNIVLIDIIGSINGNIFTSTMSVLNYLSQLSRHLMILGAIIAVKYKSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P00</accession>
    <name>Q73P00_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxyacid dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971609.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682316.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1000"/>
    <dbReference type="EnsemblBacteria" id="AAS11490">
        <property type="protein sequence ID" value="AAS11490"/>
        <property type="gene ID" value="TDE_1000"/>
    </dbReference>
    <dbReference type="GeneID" id="2739077"/>
    <dbReference type="KEGG" id="tde:TDE_1000"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.960"/>
    <dbReference type="eggNOG" id="COG2084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_1_0_12"/>
    <dbReference type="OMA" id="IFVDHTT"/>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="3">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="4">
        <location>
            <begin position="169"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="292" mass="31489" checksum="7D2DC737881D4334" modified="2004-07-05" version="1">MKVENCDVGFIGLGVMGKSMAERLRAAGAKMHVFTRTKKSAEEILSKGAIWYDDPASLAPNCKIIFTIVGYPQDVEETYFGEKGLLKTAKPGTIFADMTTSSPILAKKIYDEAKKKECFSVDAPVSGGDIGAKNGTLSIMAGGDESAFKELEPFFACMGKTWALQGGAGAGQHTKMANQIAVAANLFGTVEAVCYAEAAGLDPHKMLSAIGGGAAGSWQILNNGPKMLQKDFAPGFYIKHFLKDLNITLNVAKELKLHIPVLELAQNFFNKMNEEGYAEKGTQAIYEYYKTL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P19</accession>
    <name>SYN_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="1">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">asnS</name>
        <name type="ordered locus">TDE_0980</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971590.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682293.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73P19"/>
    <dbReference type="SMR" id="Q73P19"/>
    <dbReference type="STRING" id="243275.TDE_0980"/>
    <dbReference type="EnsemblBacteria" id="AAS11471">
        <property type="protein sequence ID" value="AAS11471"/>
        <property type="gene ID" value="TDE_0980"/>
    </dbReference>
    <dbReference type="GeneID" id="2740552"/>
    <dbReference type="KEGG" id="tde:TDE_0980"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.942"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_12"/>
    <dbReference type="OMA" id="DNMDLAE"/>
    <dbReference type="OrthoDB" id="1138123at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176471" description="Asparagine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <sequence length="473" mass="54287" checksum="BAA24B3D92DF1EC1" modified="2004-07-05" version="1">MIHLIKDILTSEPKGQAIDVYGWVRTKRETKNLVFIEINDGSCFASIQATFDRDTGLDNNTEALLKKAGTGVSVKVSGNLVPSPAAGQRVELQANNIHIFGDADQEKYPLQKKRHSMEFLRDIAHLRARTNTFGAVARIRSQMAYAIHTFFQERGFQYVHTPIITGSDCEGAGEMFHVTTFDIEETVKKALKEKKDPDSFKIDYSQDFFGKQANLTVSGQLEGETYATALSRIYTFGPTFRAENSNTSRHLAEFWMVEPEMSFFTIKENMELAEEFIVYLLKWALEKCKEDLEFFDSRIKKGLIEMLKNVVNTPFTRLTYTEAIAELEKHIDRFEFKPYWGCDLQSEHERFLTEEVYKGPVIVTNYPKEIKSFYMKLNEDGKTVRAMDVLVPGLGEIIGGSEREENLDILQGRIKELGLREEDYWWYLDLRRYGTVPHSGFGLGFERLLLYVTGMGNIRDVIPFPRAPKLAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P63</accession>
    <name>Q73P63_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971546.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0936"/>
    <dbReference type="EnsemblBacteria" id="AAS11427">
        <property type="protein sequence ID" value="AAS11427"/>
        <property type="gene ID" value="TDE_0936"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0936"/>
    <dbReference type="HOGENOM" id="CLU_3367947_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="35" mass="4177" checksum="0ED81D71CC361441" modified="2004-07-05" version="1">MGSLFDLRYIQAKTMLKAEYSKNIFKPSKKRELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PA8</accession>
    <name>Q73PA8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0891</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971501.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682171.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0891"/>
    <dbReference type="EnsemblBacteria" id="AAS11382">
        <property type="protein sequence ID" value="AAS11382"/>
        <property type="gene ID" value="TDE_0891"/>
    </dbReference>
    <dbReference type="GeneID" id="2739765"/>
    <dbReference type="KEGG" id="tde:TDE_0891"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.861"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_5_1_12"/>
    <dbReference type="OMA" id="IVAGDTW"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="306" mass="35534" checksum="A6E4FC79B09A1284" modified="2004-07-05" version="1">MKFERILEIIIYLLNHEKVSAKYLAEYFDVSVRTIQRDMVSIAEAGIPVYTLGGRYGGYAVLENYKIKNINIKNSEQQIIISALESLATSYTNDKLNSLIEKYNAIIEKEGGQKVFWDFSVTKENKKVQDSNMLLEKAIGGKNYIVFDYRNSEGKSSHVCAEPLAIHYKWYAWYLFAYPKETKEYRTFKVARMQNLVISKERSFIKHGDIQQKMKEAELAYYKTCINIEIIFSEKEIPLIEEYFPDSVIEKLSSQKCKTHIHVPAKERLWKALLLSFGDAVTVVSPKDYKEDLIKTAETFLSNYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PC5</accession>
    <name>Q73PC5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971484.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0874"/>
    <dbReference type="EnsemblBacteria" id="AAS11365">
        <property type="protein sequence ID" value="AAS11365"/>
        <property type="gene ID" value="TDE_0874"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0874"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.844"/>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045647_5_3_12"/>
    <dbReference type="OMA" id="DGWRFYT"/>
    <dbReference type="OrthoDB" id="1771906at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="171" mass="19181" checksum="7055C2045B4BCDA6" modified="2004-07-05" version="1">MVEAILYLEGDPLTDEALCKISGLSPEIVSDAIKALQESYASPQSGIELAKMMGGWVIMPKKDLWEHLKDRYGKKNEGRLSRAAMETLSIIAYSQPVTRAEIEAIRGVSADNMIRLLIEKDLIKEVGKKDVPGKPAMFGTTKEFLKIFRLNSIADLPKLDETERERFELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PD6</accession>
    <name>Q73PD6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MgtC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_0863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971473.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677254.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0863"/>
    <dbReference type="EnsemblBacteria" id="AAS11354">
        <property type="protein sequence ID" value="AAS11354"/>
        <property type="gene ID" value="TDE_0863"/>
    </dbReference>
    <dbReference type="GeneID" id="2741374"/>
    <dbReference type="KEGG" id="tde:TDE_0863"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.832"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079292_0_0_12"/>
    <dbReference type="OMA" id="FMLIIMI"/>
    <dbReference type="OrthoDB" id="2022224at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="227" mass="24435" checksum="C640D753D41A8D5F" modified="2004-07-05" version="1">MDAGALTDKIIIIRLLLSFLAGCCIGMERSGKRQVAGLRTHILICVGACGMMLISIWLPQMSGKGDTARIAAQVVSGMGFLGAGAILKIGANVKGLTTAASIWVIAGIGLAIGSGLYTAGIVMTVISLVTLSLVNRLELKIFPVRQNKFLEIYFHGNKPPMTEIINVLSDYSASIVSTNVRSSKSSKEHSKVVLFINVPKRLDISKMTEDFQKIEEVDTIVLREKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PF5</accession>
    <name>Q73PF5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">TDE_0844</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971454.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682103.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0844"/>
    <dbReference type="EnsemblBacteria" id="AAS11335">
        <property type="protein sequence ID" value="AAS11335"/>
        <property type="gene ID" value="TDE_0844"/>
    </dbReference>
    <dbReference type="GeneID" id="2739621"/>
    <dbReference type="KEGG" id="tde:TDE_0844"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.813"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015345_0_2_12"/>
    <dbReference type="OMA" id="HFFHEVG"/>
    <dbReference type="OrthoDB" id="997616at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEP-utilizers" evidence="13">
        <location>
            <begin position="409"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="14">
        <location>
            <begin position="522"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="883"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="921"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="834"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="606"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="749"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="770"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="772"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AAS11335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="935" mass="103781" checksum="ECADA8CF50E98575" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PI3</accession>
    <name>Q73PI3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, M20/M25/M40 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971426.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682078.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0816"/>
    <dbReference type="EnsemblBacteria" id="AAS11307">
        <property type="protein sequence ID" value="AAS11307"/>
        <property type="gene ID" value="TDE_0816"/>
    </dbReference>
    <dbReference type="GeneID" id="2739558"/>
    <dbReference type="KEGG" id="tde:TDE_0816"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.788"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_12"/>
    <dbReference type="OMA" id="ECSCANV"/>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="188"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="397" mass="43417" checksum="4EAF876411572BB5" modified="2004-07-05" version="1">MSNDFILKNVSNLEEYLISTRRYLHENPEVSHKEYQTSTFLKQEIKKLEFEIIETPGTGFIAILDTGKEGKTVALRTDIDALPIQENVMNLRKKKVSVSKNDGAMHACAHDGHMAIILAAAKILNEMKDLLAGKIIFMFEESEEAGGGAEQLIEILKNYKIDAIYGNHLVSFIEAGKISVDAGPVMAGAILVDFKVIGKGGHGSRPDLSISPIFGSANVLTALASAWSNQIDVTKTVTLGLGSINGGTVFNVIPDEVKITGSLRFYDSEEGEKAINIMKTTSKHAAMSQNCSVEFTEGANQIAVHPVINDIKLSKIARDGINEILPGVLTQGVKWFASESFSKYNCLAPIVFAFVGIKNLEEGMGAEHHNEFFDMDEKALYYGTAAQVKFVYDYLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PJ6</accession>
    <name>Q73PJ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971413.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682060.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11294">
        <property type="protein sequence ID" value="AAS11294"/>
        <property type="gene ID" value="TDE_0803"/>
    </dbReference>
    <dbReference type="GeneID" id="2739545"/>
    <dbReference type="KEGG" id="tde:TDE_0803"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.776"/>
    <dbReference type="eggNOG" id="ENOG5030QXQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_554259_0_0_12"/>
    <dbReference type="OrthoDB" id="547436at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="492" mass="55951" checksum="4800575D20B4D58D" modified="2004-07-05" version="1">MKTTKICSLFLILVSLFALLTGCASMYIHGSTPVQRAASAADLLIGGNVSDDYIRVYNTEVSKAERSIMDMISKAERNDIYYADIADNISDWMLLYSRISTLQRMYPEGLRGKREFAVFETRDYSNLKDTAYTRATEALYNEALRIVQISGNDPKNISKALANLKRAKKYSHHLDNEIDSLGAETAYNAAEALAYTNKPDNLLQASEYYMLANSWISGYRGSLEKSRLAKEKAAYFYIEEGSYNLKLKDYTAFRHAKASFKKAEKIIPGIASREIAEVNRKLTVRLAIVKPDNNYTDEDRIRRAITSELVSANSGPEIIEITFIRGGINSIFNLIDIRDADLALIPSDNYGKVKEIYGPVYPVNKNVSKTINGVVYNGIIMEQSQLVTVYAQNDFVLYDIRTWRKTELRYFSTETNKLSKNFTARYYSGAPEAKPADFDPGFLYESGQYKRFFPELMNEKNSMNLINNYGSLSSYGKELCNVIRNLQYIERR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PM7</accession>
    <name>RL22_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplV</name>
        <name type="ordered locus">TDE_0772</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971382.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PM7"/>
    <dbReference type="SMR" id="Q73PM7"/>
    <dbReference type="STRING" id="243275.TDE_0772"/>
    <dbReference type="EnsemblBacteria" id="AAS11263">
        <property type="protein sequence ID" value="AAS11263"/>
        <property type="gene ID" value="TDE_0772"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0772"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.745"/>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_3_1_12"/>
    <dbReference type="OMA" id="KRIQPRA"/>
    <dbReference type="OrthoDB" id="1666043at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000125253" description="50S ribosomal protein L22">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <sequence length="118" mass="13336" checksum="928320C2332B3F34" modified="2004-07-05" version="1">MTERTGYRATTKFLIASPTKVRPVANVVKNKPYPEAMAILENMPQKGAVLISQTMKSAASNALYKNKQLDEDMLFVKEIMIDEGPRLKRIWCRGKGRADILLKRMCHITVVVDERAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PW2</accession>
    <name>Q73PW2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971296.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0683"/>
    <dbReference type="EnsemblBacteria" id="AAS11177">
        <property type="protein sequence ID" value="AAS11177"/>
        <property type="gene ID" value="TDE_0683"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0683"/>
    <dbReference type="HOGENOM" id="CLU_3334242_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="38" mass="4407" checksum="6D2201930FDAB98C" modified="2004-07-05" version="1">MFNKISKDWAGAAPLPSSNYRLVNAIFSKIFKKKFIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PW6</accession>
    <name>Q73PW6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase, class V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971292.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681891.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0679"/>
    <dbReference type="EnsemblBacteria" id="AAS11173">
        <property type="protein sequence ID" value="AAS11173"/>
        <property type="gene ID" value="TDE_0679"/>
    </dbReference>
    <dbReference type="GeneID" id="2739672"/>
    <dbReference type="KEGG" id="tde:TDE_0679"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.660"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_4_12"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010969">
        <property type="entry name" value="Cys_dSase-rel_unknwn_funct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01977">
        <property type="entry name" value="am_tr_V_EF2568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="2"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="382" mass="41179" checksum="8383CFFBC26FA147" modified="2004-07-05" version="1">MIYLDNSATTLQKPESVAQEVFRGIASHQFGNPGRGAHSTAHAALTELFKTRQTLAKLFNIKNPLNVALCQNATSALNLVIKSLFSGKENTHVITTVLEHNSVLRPLYQLEKDGAELSIIPIQDGFLCYELIEKEVKSNTKAIIVNHCSNVIGSICNLDYVHSICKKHGLILIVDASQSAGTIPIDASKYGQSIFCFTGHKGLYGPQGTGGIIVNGTFEFAPVFSGGSGVRSFDKTHPSEMPDIFEAGTMNVPSFMGLNAGASYVLKTGISSIQKKLADLKLLFIEEIKTIPNLKIYGNPWSEKTGAVVGINIGDIPSGEISRLLDEEFGIASRPGAHCAPLVHKALGTEEQGIVRFSFSSFNTFEEVKQAAEALKQIAQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PX0</accession>
    <name>Q73PX0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971288.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681887.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0675"/>
    <dbReference type="EnsemblBacteria" id="AAS11169">
        <property type="protein sequence ID" value="AAS11169"/>
        <property type="gene ID" value="TDE_0675"/>
    </dbReference>
    <dbReference type="GeneID" id="2739668"/>
    <dbReference type="KEGG" id="tde:TDE_0675"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.656"/>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071599_0_0_12"/>
    <dbReference type="OMA" id="QGDYGLW"/>
    <dbReference type="OrthoDB" id="1264438at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="6"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="285" mass="32942" checksum="869852F95867B179" modified="2004-07-05" version="1">MTEKIEKLKQVLSEAETIVIGAGSGLSTSAGFTYSGERFEKYFSDFEVKYGFHDMYSGGFTPFESLEELWAYWSRNIMINRYMDPPKPVYKDLFSLVKDKDYFVITTNVDHCFQKAGFDKNRLFYTQGDYGLFQCSEPCHEKTYDNEKQIRAMWEFRDEMKVPTELVPRCPVCGKPMSMNLRADHTFVTDKGWYKASKQYEKFLQTRNIIKNGEQEGDGKVLFLELGVGGNTPGIIKYPFWQMTEKNPNARYACINFGEAVVPPKIEKQSICINDDIGEVLKKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PY5</accession>
    <name>Q73PY5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971273.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956794.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0660"/>
    <dbReference type="EnsemblBacteria" id="AAS11154">
        <property type="protein sequence ID" value="AAS11154"/>
        <property type="gene ID" value="TDE_0660"/>
    </dbReference>
    <dbReference type="GeneID" id="2739208"/>
    <dbReference type="KEGG" id="tde:TDE_0660"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.640"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_5_1_12"/>
    <dbReference type="OMA" id="RLPPVMF"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="301" mass="34601" checksum="36A21470989EC92D" modified="2004-07-05" version="1">MRSERLFEIVFILLSRKQTTAQELAKKFGVSVRTIYRDMDILSSAGIPVYTMQGTGGGIFIDESYTINKSILTKGEQEKILLALQCLSPIDEIHTESILNRLSAIFQKNADWIRIDYSRWDNKNDHHLFKTLKDAILERRAVKLEYLSSYGEKTERTVYPLRLLYKSKAWYAECYCTEKNACRLFRLTRILSIIKTLKTFNRADLLGKIPDDKKAAPPPLTNIKLKCTAKTAYRLYDEFPPELIAKNSDGSYTLNAALPFDSWVCGFILSLGTEVEILEPENLKTEIAQLAEEIMKKHRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q42</accession>
    <name>Q73Q42_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">fabH</name>
        <name evidence="10" type="ordered locus">TDE_0602</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971216.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681779.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0602"/>
    <dbReference type="EnsemblBacteria" id="AAS11097">
        <property type="protein sequence ID" value="AAS11097"/>
        <property type="gene ID" value="TDE_0602"/>
    </dbReference>
    <dbReference type="GeneID" id="2739158"/>
    <dbReference type="KEGG" id="tde:TDE_0602"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.582"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_4_0_12"/>
    <dbReference type="OMA" id="WGSEGDK"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="107"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="222"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="239"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="311" mass="33384" checksum="3F9F806042A807DB" modified="2004-07-05" version="1">MAIIIKTTGKSIPKKIMHNSDFPASLDTSDEWIRSHTGIGSRYIASQEDTSASLGAEACKQVLANENLNPQDIDLIICATATAEYQGFPSNACLIQKELGAKNAACFDLSAACSGFLYAIDTAAALMERHGRRYALVCGTEVLSKIIDWQDRSTCVLFGDGAGAALLENTFDNSKRGIGSVILGSDGTGYEALYMADHLKMNGRTVYNFAVGVITETVKSLLQKENINMEDVDLVVCHQANKRILEAAAKRLNTDMSKFACNMENYGNTSAASIPITLDDLRLQGKLTEGTTIITAGFGAGLTWGGAVIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q72</accession>
    <name>Q73Q72_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971185.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73Q72"/>
    <dbReference type="STRING" id="243275.TDE_0571"/>
    <dbReference type="EnsemblBacteria" id="AAS11066">
        <property type="protein sequence ID" value="AAS11066"/>
        <property type="gene ID" value="TDE_0571"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0571"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.555"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_1_2_12"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284637" evidence="1">
        <location>
            <begin position="37"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="513"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="760" mass="83090" checksum="38C1AE13F7111F2B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QB8</accession>
    <name>Q73QB8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971139.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002665878.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0525"/>
    <dbReference type="EnsemblBacteria" id="AAS11020">
        <property type="protein sequence ID" value="AAS11020"/>
        <property type="gene ID" value="TDE_0525"/>
    </dbReference>
    <dbReference type="GeneID" id="2739262"/>
    <dbReference type="KEGG" id="tde:TDE_0525"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.511"/>
    <dbReference type="eggNOG" id="COG3656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105848_0_0_12"/>
    <dbReference type="OMA" id="EATIYQD"/>
    <dbReference type="OrthoDB" id="1636280at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014469">
        <property type="entry name" value="DUF2271"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10029">
        <property type="entry name" value="DUF2271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="177" mass="20057" checksum="8FDFC00882C82B89" modified="2004-07-05" version="1">MRKIILTILIIFTAFSVNISAGELNIQKNTISISFDFSKKLRLASNQFAVWVENENGMLVKNLFVTDFTAGKGWEKRPESLPSWRKAVKDADIDGISSATPKSGKIQLQWDIKNENGEPVEKGIYKIFIEANIKWENTVLFTCEIKVDDNVTIGEITEKISGKDYNKQTLIKNVEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QC8</accession>
    <name>Q73QC8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971129.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681648.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0515"/>
    <dbReference type="EnsemblBacteria" id="AAS11010">
        <property type="protein sequence ID" value="AAS11010"/>
        <property type="gene ID" value="TDE_0515"/>
    </dbReference>
    <dbReference type="GeneID" id="2739252"/>
    <dbReference type="KEGG" id="tde:TDE_0515"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.501"/>
    <dbReference type="eggNOG" id="ENOG502Z9QZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831038_0_0_12"/>
    <dbReference type="OrthoDB" id="1906975at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="337" mass="38786" checksum="87FD9C97507B7077" modified="2004-07-05" version="1">MQVKLDKISEWTTTGFKLNNGAYQYAPINAKNHFARGKDEFVIWGSGDDGTSYGIVWIKAGRWSFIPSPAQKKSWNKPVLLDTGSDILIISGEDKKAWWVSSPEQKPCEVVSENLCAAENITEISTLGEKGVYPIICRVDGEVFAANSFTSLHYDNETHTLHWDKQLITVFTNEKVRSNFMLSLGRAEGIHHKMDFSYSYPQIGSLMIKDNSIYAFVEADTINPCSLSQFKYYWYLELTQDGIYKRQIWGKEKLERLAQKHGLRGKFSAQKEYLILSPIFKTDEWKGKQKLLRLSDLELLDITLPRGYSKFRIMDIWDNHVFISDEIDHIALCRMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QE5</accession>
    <name>Q73QE5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971112.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681620.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0498"/>
    <dbReference type="EnsemblBacteria" id="AAS10993">
        <property type="protein sequence ID" value="AAS10993"/>
        <property type="gene ID" value="TDE_0498"/>
    </dbReference>
    <dbReference type="GeneID" id="2738983"/>
    <dbReference type="KEGG" id="tde:TDE_0498"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.483"/>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2235385_0_0_12"/>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="105" mass="12423" checksum="572C76990CD8BFF9" modified="2004-07-05" version="1">MFIGREKELSYLNEFYQKPGLGMTVIYGRRRIDKFTLISEFVKDKKVIFYTATKVGKERNLELFSKQVTDVFLAGIEDRSFRTIRLHDSLQDEKTVLVSLDEMYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QH9</accession>
    <name>Q73QH9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NifU domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971078.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681558.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0464"/>
    <dbReference type="EnsemblBacteria" id="AAS10959">
        <property type="protein sequence ID" value="AAS10959"/>
        <property type="gene ID" value="TDE_0464"/>
    </dbReference>
    <dbReference type="GeneID" id="2739218"/>
    <dbReference type="KEGG" id="tde:TDE_0464"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.450"/>
    <dbReference type="eggNOG" id="COG0694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060555_4_3_12"/>
    <dbReference type="OMA" id="CSVNQMT"/>
    <dbReference type="OrthoDB" id="2010888at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="1">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="75" mass="8163" checksum="52B434E69EACD9F3" modified="2004-07-05" version="1">MLVKEEIEKGIALVRPYLQADGGDIELDSVDEAGKVYVKLKGACGSCPMAIYTLKMGVEEQLKDMFPEVTEVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QR0</accession>
    <name>Q73QR0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970997.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681408.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0383"/>
    <dbReference type="EnsemblBacteria" id="AAS10878">
        <property type="protein sequence ID" value="AAS10878"/>
        <property type="gene ID" value="TDE_0383"/>
    </dbReference>
    <dbReference type="GeneID" id="2740315"/>
    <dbReference type="KEGG" id="tde:TDE_0383"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.372"/>
    <dbReference type="HOGENOM" id="CLU_1685804_0_0_12"/>
    <dbReference type="OrthoDB" id="1175836at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="156" mass="18386" checksum="80548DF9DF847165" modified="2004-07-05" version="1">MGKIIGLIACSSTKLGKNSPAEKYLAKDIYKGHTFILSKEEGLKKYKCEEWYILSGKYGLLDKDEYISYYNLYLGKQSTEYKKKWAEDVLNKLKSKYELKNDIFYIFGGKSYYEHLMPHLNCVVFRYKNSNCIDLDKKNEYRNGKPHDSKSDRIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QU8</accession>
    <name>Q73QU8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein DmcB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dmcB</name>
        <name evidence="6" type="ordered locus">TDE_0345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970959.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="IntAct" id="Q73QU8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0345"/>
    <dbReference type="EnsemblBacteria" id="AAS10840">
        <property type="protein sequence ID" value="AAS10840"/>
        <property type="gene ID" value="TDE_0345"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0345"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.334"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_18_12"/>
    <dbReference type="OMA" id="ERMSASC"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="124"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="410" mass="43720" checksum="DDF88253B745D4DA" modified="2004-07-05" version="1">MSIRILGIIILIITLAVIYAVAHYMLHPIRKTVSALKDIAQGKGDLTVRLPINGNDEITDLSEYFNQTIEKIGAAIKNVGKNSVSMEAIGEELASNMTQTASAINEISANIEGVKNQTLTQAASVTETAATIEQIVRTIKQLNNSIENQAASVARSTASIEEMVANIASITQTLEKTYDVVKNLASATEDGKETIITSNSVTQKIAEESGSLMEASSVIQHIASQTNLLAMNAAIEAAHAGEAGKGFAVVADEIRKLAEDSATQGKTITSTLKTLSSEIESLSVSSKTVEDKFSTIFNLSEQVKSMSDRLTEAMHEQENGSKEVLGAIKNINTVTVEVQAGSEEMLKGGEGVAEEMLKLDNLTRMITDSMNEMAAGAVQINNAVQEVNAITQKNKTSIENLAAEVGKFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QV4</accession>
    <name>Q73QV4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970953.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681311.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0339"/>
    <dbReference type="EnsemblBacteria" id="AAS10834">
        <property type="protein sequence ID" value="AAS10834"/>
        <property type="gene ID" value="TDE_0339"/>
    </dbReference>
    <dbReference type="GeneID" id="2739338"/>
    <dbReference type="KEGG" id="tde:TDE_0339"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.328"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_6_0_12"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="205" mass="23421" checksum="A2D022CCBF61ABD0" modified="2004-07-05" version="1">MSKSEDTKQLILDTAKREFLEKGYNAASVRTIAKKAGLTTGAIFRYYADKAALFEALVSEAADGLVEQFKAAQEAHFELIPQERTSESRDLSTEYLRHFVNYVYDRFDEFKLVLCGAEGTKYANYIHDLVELDVARTETYYRLLREKGKIKGSISLELHHMITSAYFTAVFETVVHDMPREQAMGYVEEIAVFFNSGWDGLLKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QX9</accession>
    <name>Q73QX9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970928.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681269.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0314"/>
    <dbReference type="EnsemblBacteria" id="AAS10809">
        <property type="protein sequence ID" value="AAS10809"/>
        <property type="gene ID" value="TDE_0314"/>
    </dbReference>
    <dbReference type="GeneID" id="2740513"/>
    <dbReference type="KEGG" id="tde:TDE_0314"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.303"/>
    <dbReference type="eggNOG" id="ENOG5031CP2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1093904_0_0_12"/>
    <dbReference type="OMA" id="ISMIDIP"/>
    <dbReference type="OrthoDB" id="1305860at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="250" mass="27709" checksum="C9F35D31246402E3" modified="2004-07-05" version="1">MIFIEKKLLFISLVISFIFMIITAFWAYSVGMRIPLKGDSEFVLFLGFIFSGLQLIITINIIIGAIKKKKDFFTLMETIRAGGILSQEKIKKLGSAGFALQEALEASSTITAQKSLKIASLNGLMRSLISMIDIPIVVVNLNGEIIDASQKIKTEKNYNKDLNISDLIPQANIREAFKEASISHLPVEQGNNLLIPVFSTLGDITYFLIDTSKHGALTKFINNFIPPQKEESAKQAKKGFFKILGTSKKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R87</accession>
    <name>SYE_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="1">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gltX</name>
        <name type="ordered locus">TDE_0204</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970820.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681104.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73R87"/>
    <dbReference type="SMR" id="Q73R87"/>
    <dbReference type="STRING" id="243275.TDE_0204"/>
    <dbReference type="EnsemblBacteria" id="AAS10701">
        <property type="protein sequence ID" value="AAS10701"/>
        <property type="gene ID" value="TDE_0204"/>
    </dbReference>
    <dbReference type="GeneID" id="2739810"/>
    <dbReference type="KEGG" id="tde:TDE_0204"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.198"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_12"/>
    <dbReference type="OMA" id="WDEGPFF"/>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000119686" description="Glutamate--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="251"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <sequence length="506" mass="58234" checksum="9E3D62E7D58393F2" modified="2004-07-05" version="1">MQVKVRYAPSPTGFQHIGGVRTALFNYLFARSKGGKFVLRIEDTDRTRYSEEYEQNLYDTLEWLGLEWDEGGPKGGPCAPYIQSQRFDIYRKYAQELVDKGFAYYCFCDSERLDRIRKIQTMNKMPPGYDRACRNLTDEEIKAKMDEGIPYVIRLKVPLEGSTKFTDALLGDIEWKNEDINPDQILLKSDGFPTYHLANIVDDHLMGITHVMRAQEWLPSTPMHVIMYKAFGWEPPQFCHLPMVMGNDGQKLSKRHGATSCNEFRNKGYLKEAIINYVAMLGCSYEDGRDMYSLSDLEKLFDIKHLNKAPAVFDYKKLEWFNGQYMREKTDEELFALTWPYIANSGLFGKINEEELKKAGCRFENQTYLKPTQEQKEILMKVMPLVKERLHLLSEITEMVRFLFEEPAVPPAEEIIPKKLDAETTKKVLQKAIEVMPKILGLDDHAGGEVFRAEADAMGIKMGDFMMPVRMTVTGSRISPPLVGSIQILGIEKAIKRIEKAIAERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R92</accession>
    <name>Q73R92_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970815.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0199"/>
    <dbReference type="EnsemblBacteria" id="AAS10696">
        <property type="protein sequence ID" value="AAS10696"/>
        <property type="gene ID" value="TDE_0199"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0199"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.194"/>
    <dbReference type="eggNOG" id="ENOG502ZQCQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133861_1_0_12"/>
    <dbReference type="OrthoDB" id="1789299at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="169" mass="18873" checksum="8CF70002511BA060" modified="2004-07-05" version="1">MPIGVATTNKIPTYSLYHSFSIESIEKKVYDVFMTDLQPLSWMILVFIGLFLIVFAYVLFSASAKHASGKKIRQTGKKGSPGVCPVCGTVLARDEQVKSAVYPGADDRLCYIYGCPHCYPGCEKGVQRQCPVCHKTVPNEAHLIARYFDRKKGKKRVHILGCSNCRFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RB9</accession>
    <name>Q73RB9_TREDE</name>
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            <fullName evidence="3">Nuclease SbcCD, C subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681054.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0171"/>
    <dbReference type="EnsemblBacteria" id="AAS10668">
        <property type="protein sequence ID" value="AAS10668"/>
        <property type="gene ID" value="TDE_0171"/>
    </dbReference>
    <dbReference type="GeneID" id="2739523"/>
    <dbReference type="KEGG" id="tde:TDE_0171"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.168"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004785_2_1_12"/>
    <dbReference type="OMA" id="ISHVQEM"/>
    <dbReference type="OrthoDB" id="1143316at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="6"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="451"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="720"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="809"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1030" mass="117667" checksum="EA7480ED35817387" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RF7</accession>
    <name>Q73RF7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970749.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666651.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0132"/>
    <dbReference type="EnsemblBacteria" id="AAS10630">
        <property type="protein sequence ID" value="AAS10630"/>
        <property type="gene ID" value="TDE_0132"/>
    </dbReference>
    <dbReference type="GeneID" id="44155125"/>
    <dbReference type="KEGG" id="tde:TDE_0132"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.132"/>
    <dbReference type="HOGENOM" id="CLU_212166_1_0_12"/>
    <dbReference type="OrthoDB" id="2171310at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="56" mass="6450" checksum="7B0A2074A50593C0" modified="2004-07-05" version="1">MSPVEPKKDKEEFKLVKSGDIDVYVKNKINASNDTLFVKYKKVLFSEKLIVEGIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RG1</accession>
    <name>Q73RG1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970744.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673197.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0127"/>
    <dbReference type="EnsemblBacteria" id="AAS10625">
        <property type="protein sequence ID" value="AAS10625"/>
        <property type="gene ID" value="TDE_0127"/>
    </dbReference>
    <dbReference type="GeneID" id="2739583"/>
    <dbReference type="KEGG" id="tde:TDE_0127"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.127"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_8_12"/>
    <dbReference type="OrthoDB" id="1958941at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="104" mass="11992" checksum="F5E06D6347FF1CFD" modified="2004-07-05" version="1">MSYDYESILAKNIRRIRHKLEISQMELALRADVSIAFINAIENKQKWVSAATLSKITDALNTTPYELFLTDDISQEDLTIIAGRHDELIKDLNKLLKKYTSNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RI1</accession>
    <name>Q73RI1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-amylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970724.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680963.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
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    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="541" mass="63725" checksum="4FB61BA527A9F98E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RP9</accession>
    <name>Q73RP9_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970653.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0036"/>
    <dbReference type="EnsemblBacteria" id="AAS10534">
        <property type="protein sequence ID" value="AAS10534"/>
        <property type="gene ID" value="TDE_0036"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0036"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.38"/>
    <dbReference type="eggNOG" id="COG1569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116617_4_0_12"/>
    <dbReference type="OMA" id="SCEGTPY"/>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="130" mass="14962" checksum="7DF4307E78AD2446" modified="2004-07-05" version="1">MISAILFPDGKVAKVFSHLLENHTVIISSYTKEECKKVFENKFPFKKELLGIFFDGITFEEFKSPDTIDENKYPKVRDIKDLPVLVSAILSDSDILITGDKDFEDVKIDKPLIFTPSKYFELIAEKYGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RQ7</accession>
    <name>Q73RQ7_TREDE</name>
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        <submittedName>
            <fullName evidence="9">ABC transporter, ATP-binding protein, HlyB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_0028</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970645.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680887.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0028"/>
    <dbReference type="EnsemblBacteria" id="AAS10526">
        <property type="protein sequence ID" value="AAS10526"/>
        <property type="gene ID" value="TDE_0028"/>
    </dbReference>
    <dbReference type="GeneID" id="2741643"/>
    <dbReference type="KEGG" id="tde:TDE_0028"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.30"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="370"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="404"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="624" mass="71606" checksum="7F9CA09BF236F57A" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RQ8</accession>
    <name>Q73RQ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DHH superfamily protein, subfamily 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0027</name>
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    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970644.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680886.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0027"/>
    <dbReference type="EnsemblBacteria" id="AAS10525">
        <property type="protein sequence ID" value="AAS10525"/>
        <property type="gene ID" value="TDE_0027"/>
    </dbReference>
    <dbReference type="GeneID" id="2741642"/>
    <dbReference type="KEGG" id="tde:TDE_0027"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.29"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046377_1_0_12"/>
    <dbReference type="OMA" id="DDRVHMG"/>
    <dbReference type="OrthoDB" id="1040743at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="18"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="194"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="327" mass="36532" checksum="F711C0B50C9B67D5" modified="2004-07-05" version="1">MEEKLSTLCSVLSKDQPVLVQTHDFPDHDALGAAYALLKLLETYGYKVEIAYGGHIQSLSLIEFVEYLNYPLLKLDEIDDLKKYQVVIVDGSPFKGTVKYVGGILKAVIDHHPERIQSTAAYTDIRVGIGACSSIIWSYWKESGKEYDEITATAMIAGIQLDTAFLSRGVSKLDLDAYYELYFKSDVQKTYQMIKTTINICDLEEIGRAFTDYLRIDNFLIVELSEDYSRAILSVVADFLIWIKDISFVIVLETDGPEYKLSARSRDKNLDAGWLIQEAVKDMGSGGGHAHMAGGVIDAERYCGKTVFLNSIIKLANSEQGNNCGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RR2</accession>
    <name>Q73RR2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970640.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680882.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0023"/>
    <dbReference type="EnsemblBacteria" id="AAS10521">
        <property type="protein sequence ID" value="AAS10521"/>
        <property type="gene ID" value="TDE_0023"/>
    </dbReference>
    <dbReference type="GeneID" id="2741638"/>
    <dbReference type="KEGG" id="tde:TDE_0023"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.25"/>
    <dbReference type="eggNOG" id="COG3393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076898_0_0_12"/>
    <dbReference type="OMA" id="KASHESC"/>
    <dbReference type="OrthoDB" id="1270792at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="159"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="298" mass="34237" checksum="0B12C75DC4C3075A" modified="2004-07-05" version="1">MKCSVIHLTNKNIDLFIDNILPYEYLCINLAECLKKQKRFFDMGQELFTFIKADIFFSCDKEFIGILFLAAHGVLLHCFTKEITDDIAKYIKNNFLKHTNPLSVMGEKNTSIYLEQLINESLSLVPARFENYKLLTLKTKPLTPNFFCTRASDNLNTKLEFIKPQIEDAELLCPMEIEYNESEVLAPGVKASHESCLKLLKKRINNHALYAVKKDGKYIAKAGINASGFRWNQIGGVFTIPEYRNKGVGAANMMMLTNDCFQYNKKCALFVKIKNPAARQMYKKIGFTESCDFRISYF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RR6</accession>
    <name>FTHS_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="1">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formyltetrahydrofolate synthetase</fullName>
            <shortName evidence="1">FHS</shortName>
            <shortName evidence="1">FTHFS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fhs</name>
        <name type="ordered locus">TDE_0019</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970636.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956670.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73RR6"/>
    <dbReference type="SMR" id="Q73RR6"/>
    <dbReference type="STRING" id="243275.TDE_0019"/>
    <dbReference type="EnsemblBacteria" id="AAS10517">
        <property type="protein sequence ID" value="AAS10517"/>
        <property type="gene ID" value="TDE_0019"/>
    </dbReference>
    <dbReference type="GeneID" id="2741634"/>
    <dbReference type="KEGG" id="tde:TDE_0019"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.21"/>
    <dbReference type="eggNOG" id="COG2759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003601_3_3_12"/>
    <dbReference type="OMA" id="CGEIMTM"/>
    <dbReference type="OrthoDB" id="177859at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000199405" description="Formate--tetrahydrofolate ligase">
        <location>
            <begin position="1"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="64"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01543"/>
        </source>
    </evidence>
    <sequence length="554" mass="59521" checksum="408B1B43A2DA6308" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RT0</accession>
    <name>Q73RT0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-threonine aldolase, low-specificity</fullName>
            <ecNumber evidence="4">4.1.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ltaE</name>
        <name evidence="4" type="ordered locus">TDE_0005</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.1.2.5" evidence="4"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970622.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680857.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0005"/>
    <dbReference type="EnsemblBacteria" id="AAS10503">
        <property type="protein sequence ID" value="AAS10503"/>
        <property type="gene ID" value="TDE_0005"/>
    </dbReference>
    <dbReference type="GeneID" id="2741620"/>
    <dbReference type="KEGG" id="tde:TDE_0005"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.6"/>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049619_1_0_12"/>
    <dbReference type="OMA" id="ETDCEVF"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004793">
        <property type="term" value="F:threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="351" mass="39295" checksum="E3D4C00E9A2710EC" modified="2004-07-05" version="1">MYFFINDYSEGCHPKILKALTETNEEQTVGYGCDEYCAEAADLILKELDAPQSKVYFFSGGTQTNLTMIASVLRPHQGVIAADTGHINVHESGAIEACGHKVLTIESANGKITAEQAEALIRAHYDDPTAEHMVQPGMIYISNPTELGTIYSKKELQALKLTAQKYSVPLYVDGARLGTALTADNNDLSLADMARYTDAFYIGGTKMGALFGEALIINNQDLQKDFRYIQKQKGGLFAKGRLLGLQFKTLFKDKLYFEIGRTMNETAKMIRKGFSDRGFSFFMKSETNQSFPIIENSLLAKIEKEFKCEFWAKISENQTAVRFCTSWATTKEAVKKLFEYVDEINSNAIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73IZ9</accession>
    <name>Q73IZ9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PspC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2778</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973376.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673411.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2778"/>
    <dbReference type="EnsemblBacteria" id="AAS13295">
        <property type="protein sequence ID" value="AAS13295"/>
        <property type="gene ID" value="TDE_2778"/>
    </dbReference>
    <dbReference type="GeneID" id="2740745"/>
    <dbReference type="KEGG" id="tde:TDE_2778"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2622"/>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143433_0_2_12"/>
    <dbReference type="OMA" id="FMNPLMI"/>
    <dbReference type="OrthoDB" id="2022704at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS13295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="77" mass="8622" checksum="F8509115EB152C7E" modified="2004-07-05" version="1">MKKRLCKSSRDKKILGVCAGLAEYLGVDPVLIRLLWIIFALVVGSGIIAYIIAAIIMPYDTEVKDDDDESYEYAPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J04</accession>
    <name>Q73J04_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973371.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2773"/>
    <dbReference type="EnsemblBacteria" id="AAS13290">
        <property type="protein sequence ID" value="AAS13290"/>
        <property type="gene ID" value="TDE_2773"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2773"/>
    <dbReference type="HOGENOM" id="CLU_3190268_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="46" mass="5445" checksum="A6B6C3210BDB85EE" modified="2004-07-05" version="1">MLSSPGYFLPQKNFVKFAVFPFKLSFLKKVFYSLVMLIPNNFLPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J20</accession>
    <name>Q73J20_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacterial extracellular solute-binding protein, family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973354.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957310.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2756"/>
    <dbReference type="EnsemblBacteria" id="AAS13273">
        <property type="protein sequence ID" value="AAS13273"/>
        <property type="gene ID" value="TDE_2756"/>
    </dbReference>
    <dbReference type="GeneID" id="2740723"/>
    <dbReference type="KEGG" id="tde:TDE_2756"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2601"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_0_4_12"/>
    <dbReference type="OMA" id="HFINNGA"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284549" evidence="1">
        <location>
            <begin position="21"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="76"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="539" mass="61317" checksum="78DD6469A92E825D" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J33</accession>
    <name>Q73J33_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type I restriction-modification system, S subunit, truncation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973341.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680806.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2743"/>
    <dbReference type="REBASE" id="6395">
        <property type="entry name" value="S.TdeORF2746BP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13260">
        <property type="protein sequence ID" value="AAS13260"/>
        <property type="gene ID" value="TDE_2743"/>
    </dbReference>
    <dbReference type="GeneID" id="2740962"/>
    <dbReference type="KEGG" id="tde:TDE_2743"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2589"/>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021095_7_4_12"/>
    <dbReference type="OMA" id="NCTIIGR"/>
    <dbReference type="OrthoDB" id="827072at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="24"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="175" mass="19690" checksum="678D46976E1E2287" modified="2004-07-05" version="1">MLSCYYEKFGDVTETAVEMFSAIPESWTWCHFGDVADVINGKNQSQVEDDTGEYPIYGSGGIMGYANDYICPKNCTIIGRKGSINNPIFVEEKFWNVDTAFGLAPSSIVLPRYLFYFCKSFDFTSLDSSTTLPSLTKTSIRSILFPLPPFVAQQRILDKIDELFSQLEKIALNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J67</accession>
    <name>Q73J67_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BNR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973307.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680753.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2709"/>
    <dbReference type="EnsemblBacteria" id="AAS13226">
        <property type="protein sequence ID" value="AAS13226"/>
        <property type="gene ID" value="TDE_2709"/>
    </dbReference>
    <dbReference type="GeneID" id="2739296"/>
    <dbReference type="KEGG" id="tde:TDE_2709"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2558"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001329_0_0_12"/>
    <dbReference type="OMA" id="IPGNPYW"/>
    <dbReference type="OrthoDB" id="30276at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285791" evidence="1">
        <location>
            <begin position="20"/>
            <end position="1554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1554" mass="171780" checksum="3E482808BC445C03" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J73</accession>
    <name>Q73J73_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973301.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673490.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2703"/>
    <dbReference type="EnsemblBacteria" id="AAS13220">
        <property type="protein sequence ID" value="AAS13220"/>
        <property type="gene ID" value="TDE_2703"/>
    </dbReference>
    <dbReference type="GeneID" id="2739290"/>
    <dbReference type="KEGG" id="tde:TDE_2703"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2552"/>
    <dbReference type="eggNOG" id="COG3026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074356_1_0_12"/>
    <dbReference type="OMA" id="NKSGPFM"/>
    <dbReference type="OrthoDB" id="963283at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033399">
        <property type="entry name" value="Put_LolA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17131">
        <property type="entry name" value="LolA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284534" evidence="1">
        <location>
            <begin position="26"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="261" mass="29592" checksum="FBE7C4F46F4A06C9" modified="2004-07-05" version="1">MNKSLLKKAVILFALTVLCIGFTFAEDGKSIVQKSLDVKRPKFTHSALKMTLVDSKGNTEERMIEQWAKDPGDKTGAAVIVFKKPASVKDTRFLQIVNKDRANDKWIYLPALRTVRRIAGAEGSKPFMGTDADYDDLETRKIDDDTHTLLGEETVDSYNCWKVESTAVDPKSSRYSKKITYIDKVTCIPVMAEMYDKKGALLKVLKVEKLEQKNGYWIPIKGNLTNVQTKHSTHLEILNIEIDKPINDKMFTQNFLNTGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JE9</accession>
    <name>Q73JE9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2626</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973224.1">
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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    <dbReference type="KEGG" id="tde:TDE_2626"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2483"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="26"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="340"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS13143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="581" mass="63937" checksum="56F93BDB22A8E790" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JM8</accession>
    <name>Q73JM8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">cobD</name>
        <name evidence="11" type="ordered locus">TDE_2389</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the CobD/CbiB family.</text>
    </comment>
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        <property type="protein sequence ID" value="AAS12907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972988.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680319.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2389"/>
    <dbReference type="EnsemblBacteria" id="AAS12907">
        <property type="protein sequence ID" value="AAS12907"/>
        <property type="gene ID" value="TDE_2389"/>
    </dbReference>
    <dbReference type="GeneID" id="2740691"/>
    <dbReference type="KEGG" id="tde:TDE_2389"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2257"/>
    <dbReference type="eggNOG" id="COG1270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054212_0_0_12"/>
    <dbReference type="OMA" id="WGYRNER"/>
    <dbReference type="OrthoDB" id="2029688at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS12907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="357" mass="40357" checksum="73C6004BE087640E" modified="2004-07-05" version="1">MNFNFLSFSDFVFSHINFFILFCAIILDFILGDPYSFPHPVKFIGSLIKKEKVLARFCFSSPRGLKFAGFLIVIFNVSLSFCLVFFFLKLLYPYKILYFVFSVWISYTCLAARCLQKESIKVFTALQMSLEEGRKQIANIVGRDAEPLDEKGVSRACVETIAENTSDGVIAPLFFMMLLGPAGGIAYKAVNTMDSMLGYKNEKYADLGFFPAKVDDIVNYIPARLSALLILAGSFFCKLRRPAQEGSQKRISNKIIPKLATIKRGFKIWRRDCRKHSSPNSAHPESAAAGLLGLKLGGPNYYGGELVEKPFIGDEVFEIEDEDIKRCIQLMYASEIFMFGLYAFLFFGNVFSVFSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JQ1</accession>
    <name>Q73JQ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973056.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2458"/>
    <dbReference type="EnsemblBacteria" id="AAS12975">
        <property type="protein sequence ID" value="AAS12975"/>
        <property type="gene ID" value="TDE_2458"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2458"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2326"/>
    <dbReference type="HOGENOM" id="CLU_3105031_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="51" mass="5654" checksum="3205B62EF3F00088" modified="2004-07-05" version="1">MKIRMAYCLSFSSSEGTKNSTTEEKYVQVVAVGFNTLRYDVGVGVLNPPHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JR9</accession>
    <name>Q73JR9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3343 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973063.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675925.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2465"/>
    <dbReference type="EnsemblBacteria" id="AAS12982">
        <property type="protein sequence ID" value="AAS12982"/>
        <property type="gene ID" value="TDE_2465"/>
    </dbReference>
    <dbReference type="GeneID" id="2739650"/>
    <dbReference type="KEGG" id="tde:TDE_2465"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2332"/>
    <dbReference type="eggNOG" id="ENOG5031CM0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167443_4_1_12"/>
    <dbReference type="OrthoDB" id="1844146at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021778">
        <property type="entry name" value="Se/S_carrier-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11823">
        <property type="entry name" value="DUF3343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3343" evidence="1">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="86" mass="9822" checksum="1B28F02915408C46" modified="2004-07-05" version="1">MKEYLITFHTHYDSLVCMRAVNKTDNAKTGELTAKLVPVPRSVSSSCGTALKLIFKEGLAFDKDYFSQFDYDAFYYLSEDGKYVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JT5</accession>
    <name>Q73JT5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DJ-1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973098.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673829.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2500"/>
    <dbReference type="EnsemblBacteria" id="AAS13017">
        <property type="protein sequence ID" value="AAS13017"/>
        <property type="gene ID" value="TDE_2500"/>
    </dbReference>
    <dbReference type="GeneID" id="2741473"/>
    <dbReference type="KEGG" id="tde:TDE_2500"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2367"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_2_12"/>
    <dbReference type="OMA" id="TSYPAMK"/>
    <dbReference type="OrthoDB" id="1421548at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="184" mass="19047" checksum="739D9F4520044098" modified="2004-07-05" version="1">MKKAFLFLANGFEDVEALTPIDYLRRAGIDLITVGVGGKTIVSSHKVPITCDIVLEEALQKDGDLIAVILPGGLPNSSTLAGSEAVREFAKKTLAGGGIVAAICAAPALALGSWGLLEGKNYTCYPGMGQDLSTKPKAGERVIRDGNIITACAAGAAEEFAFAIVEAICGKTALNKLKTEVVAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JU6</accession>
    <name>RF1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide chain release factor 1</fullName>
            <shortName evidence="1">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prfA</name>
        <name type="ordered locus">TDE_2489</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973087.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680455.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JU6"/>
    <dbReference type="SMR" id="Q73JU6"/>
    <dbReference type="STRING" id="243275.TDE_2489"/>
    <dbReference type="EnsemblBacteria" id="AAS13006">
        <property type="protein sequence ID" value="AAS13006"/>
        <property type="gene ID" value="TDE_2489"/>
    </dbReference>
    <dbReference type="GeneID" id="2741462"/>
    <dbReference type="KEGG" id="tde:TDE_2489"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2355"/>
    <dbReference type="eggNOG" id="COG0216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_12"/>
    <dbReference type="OMA" id="ISDHRVG"/>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000263386" description="Peptide chain release factor 1">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="361" mass="41353" checksum="541975F277EDC1F1" modified="2004-07-05" version="1">MKERLDNLRKRLVEVEKEVENPNLIKDVAKYKETMREHSYLSKLMEEYDNYLSIEKQIEDSKLLIQEESDAELKEMAREELHSLEAAFEKSEADLKMLLIPPDPLEEKNIIMEIRGGTGGDEAALFAADLFRMYTHYAEMKNWKYEVLSLNETELGGYKEITFSISGKYVYGSLRYESGVHRVQRVPETEGSGRIHTSAVTVAVLPEAEETEIEINQEDLRIDVMRAGGPGGQCVNTTDSAVRITHIPTGLVVICQDEKSQIKNKAKAMRVLRSRLYDLEESKKQAERAQNRKSQVGSGDRSERIRTYNFPQNRVTDHRINLTLYKLDAVMQGSLDELIDALCIAAREEMMKAADHHLEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K07</accession>
    <name>Q73K07_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973156.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680530.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2558"/>
    <dbReference type="EnsemblBacteria" id="AAS13075">
        <property type="protein sequence ID" value="AAS13075"/>
        <property type="gene ID" value="TDE_2558"/>
    </dbReference>
    <dbReference type="GeneID" id="2739923"/>
    <dbReference type="KEGG" id="tde:TDE_2558"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2417"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_12"/>
    <dbReference type="OMA" id="HIMAFTI"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="340"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS13075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="552" mass="60964" checksum="A08E91FB5185754F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K28</accession>
    <name>Q73K28_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_2589</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973187.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667252.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2589"/>
    <dbReference type="EnsemblBacteria" id="AAS13106">
        <property type="protein sequence ID" value="AAS13106"/>
        <property type="gene ID" value="TDE_2589"/>
    </dbReference>
    <dbReference type="GeneID" id="2741293"/>
    <dbReference type="KEGG" id="tde:TDE_2589"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2448"/>
    <dbReference type="eggNOG" id="COG1362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590123_0_0_12"/>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="OrthoDB" id="304020at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS13106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="468" mass="51816" checksum="994EA3766C6EE6DA" modified="2004-07-05" version="1">MDLSYKQKSAWENLTKAELSELGKLSDSYLDFLDNGKTERECTVEIIKQAKKHGFKSLEEVVKSGSAKKGTKVYLNNKEKSVVLMVLGDDITQGMNIIGAHIDSPRLDLKQMPLFEESNMAFLKTHYYGGVKKYQWTTIPLAIHGVIFTKEGKKVDICIGEDEKDPVLFINDLLIHLSKKQLQETMSEGITGEQLNILVGNQKPSSKEKKDDKKEESKNPVKDNILKILNEKYGIIEEDFRVAELEVVPAGKARNVGFDSSLIAGHGHDDRVCAYTSLKAILEVESPKRTAVALFADKEEIGSVGNTGMQALYFENMVAEIAALNKNYRDIDVRRAFANSYMLSADVSAGFDPAFPSVFEKMNSAYIGNGICINKYTGSGGKGGSNDANAEFLQRIRKIFDDNKVVWQTAELGKIDAGGGGTIAYIIAKYGAEVVDCGVPVLSMHAPFEILSKADLYMAYKAYRAFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K49</accession>
    <name>Q73K49_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Precorrin-6Y C5,15-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972972.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680295.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2373"/>
    <dbReference type="EnsemblBacteria" id="AAS12891">
        <property type="protein sequence ID" value="AAS12891"/>
        <property type="gene ID" value="TDE_2373"/>
    </dbReference>
    <dbReference type="GeneID" id="2739982"/>
    <dbReference type="KEGG" id="tde:TDE_2373"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2241"/>
    <dbReference type="eggNOG" id="COG2241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089162_2_0_12"/>
    <dbReference type="OMA" id="DPCFSGL"/>
    <dbReference type="OrthoDB" id="1195697at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="199" mass="22492" checksum="EA3C5AC1B73A1D1D" modified="2004-07-05" version="1">MPLTVAGAGPGNIELLTQEAIRAIKDADIVAGFERIASDVRPIRNDVKTLKGISEILDLPIETKKVLVLASGDPCFFGITEFIKNKNIKIEKVITGISSMQYFMAKIQKQWQTLPFYSFHGRETDFTEMHSKDSFFILTDKTNNPDIISARLKEEGFKGRLFVGYNLSYPDESIEEYTIGDKIIVKSFLNTVLVQNEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K50</accession>
    <name>Q73K50_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972971.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667698.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2372"/>
    <dbReference type="EnsemblBacteria" id="AAS12890">
        <property type="protein sequence ID" value="AAS12890"/>
        <property type="gene ID" value="TDE_2372"/>
    </dbReference>
    <dbReference type="GeneID" id="2739981"/>
    <dbReference type="KEGG" id="tde:TDE_2372"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2240"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_7_0_12"/>
    <dbReference type="OMA" id="INVWTTW"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284898" description="Thioredoxin domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="50"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="202" mass="22099" checksum="F2C0449F5F4D127B" modified="2004-07-05" version="1">MKKLHFYVLTAIFAGILFASCTKTEAQGDKEAEKPLTAKEIAAESEAKILSDGQNRLTFSTKDLDGNTVTSDIFENYDVTLVNIWGTFCGPCKTELPHLEAAYKAYADKKVNVIAVTADLPQDDAETLALAKDIWKDAGCTFKALVTVDSFLPMYEQLACFPTSFMVDKKGQVIPGTLHLGSLNKEGFEKLFDKALKAVASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K93</accession>
    <name>Q73K93_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobQ</name>
        <name evidence="4" type="ordered locus">TDE_2326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972926.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2326"/>
    <dbReference type="EnsemblBacteria" id="AAS12845">
        <property type="protein sequence ID" value="AAS12845"/>
        <property type="gene ID" value="TDE_2326"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2326"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2195"/>
    <dbReference type="eggNOG" id="COG1492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019250_0_0_12"/>
    <dbReference type="OMA" id="PSGNGRM"/>
    <dbReference type="OrthoDB" id="744477at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="286" mass="31765" checksum="C52B7A7290EAD482" modified="2004-07-05" version="1">MCSKPMASIMIQGTTSSAGKSLFCTGLCRIFKKKGLKVVPFKSQNMSSIFFTTADGKKISSAQALQARAAGIEPRPEMNPILLIPKTDVGSKVIILGEEKKEMKAREYFEYKKTCKPMILKTFQKLEKENDIVVIEGAGSPAEINLNQNDIVNMGMAEMADAPVLLIADIDRGGVFAQLYGTVMLLPEKDRKRIKGMIINKFRGDKSLLDPGIKMIEDLVKIPVIATIPYMHLELADEDSLIDDDKRCNTQAQSDAELEKELDKLAALIEENSDMDFIFKTAFTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KA6</accession>
    <name>Q73KA6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972913.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680227.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2313"/>
    <dbReference type="EnsemblBacteria" id="AAS12832">
        <property type="protein sequence ID" value="AAS12832"/>
        <property type="gene ID" value="TDE_2313"/>
    </dbReference>
    <dbReference type="GeneID" id="2740278"/>
    <dbReference type="KEGG" id="tde:TDE_2313"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2183"/>
    <dbReference type="eggNOG" id="COG3210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010206_0_0_12"/>
    <dbReference type="OrthoDB" id="1485738at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284555" evidence="1">
        <location>
            <begin position="23"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="834" mass="88649" checksum="BAFCD7EC958576AE" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KG1</accession>
    <name>Q73KG1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-nucleotidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2257</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972857.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680122.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73KG1"/>
    <dbReference type="STRING" id="243275.TDE_2257"/>
    <dbReference type="EnsemblBacteria" id="AAS12776">
        <property type="protein sequence ID" value="AAS12776"/>
        <property type="gene ID" value="TDE_2257"/>
    </dbReference>
    <dbReference type="GeneID" id="2740007"/>
    <dbReference type="KEGG" id="tde:TDE_2257"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2130"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_3_12"/>
    <dbReference type="OMA" id="HYADGQN"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005144189" evidence="1">
        <location>
            <begin position="25"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="51"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="347"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="533" mass="57837" checksum="DDD6039D66103814" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KJ5</accession>
    <name>Q73KJ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972823.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2223"/>
    <dbReference type="EnsemblBacteria" id="AAS12742">
        <property type="protein sequence ID" value="AAS12742"/>
        <property type="gene ID" value="TDE_2223"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2223"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2100"/>
    <dbReference type="HOGENOM" id="CLU_3376591_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="34" mass="3684" checksum="E68C4F1CA95A305D" modified="2004-07-05" version="1">MINSSAEIQPHCLSAEFAFQANIALLYAVCKQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KK5</accession>
    <name>Q73KK5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972813.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680062.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2213"/>
    <dbReference type="EnsemblBacteria" id="AAS12732">
        <property type="protein sequence ID" value="AAS12732"/>
        <property type="gene ID" value="TDE_2213"/>
    </dbReference>
    <dbReference type="GeneID" id="2739489"/>
    <dbReference type="KEGG" id="tde:TDE_2213"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2090"/>
    <dbReference type="eggNOG" id="ENOG5032SSN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_0_0_12"/>
    <dbReference type="OMA" id="NIHSPHP"/>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="85" mass="9623" checksum="624C905E5CF10433" modified="2004-07-05" version="1">MNTKNKKTLENIYKRPVPADIFWTDIESLFISLGAEISEGAGSRIRVKLNNTRAVFHRPHPEKITDKGAVNSVRRFLENAGVEND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KM3</accession>
    <name>BIOF_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>8-amino-7-oxononanoate synthase</fullName>
            <shortName>AONS</shortName>
            <ecNumber>2.3.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>7-keto-8-amino-pelargonic acid synthase</fullName>
            <shortName>7-KAP synthase</shortName>
            <shortName>KAPA synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>8-amino-7-ketopelargonate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Alpha-oxoamine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_2194</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42288"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78846"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="EC" id="2.3.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972795.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680038.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KM3"/>
    <dbReference type="SMR" id="Q73KM3"/>
    <dbReference type="STRING" id="243275.TDE_2194"/>
    <dbReference type="EnsemblBacteria" id="AAS12714">
        <property type="protein sequence ID" value="AAS12714"/>
        <property type="gene ID" value="TDE_2194"/>
    </dbReference>
    <dbReference type="GeneID" id="2740216"/>
    <dbReference type="KEGG" id="tde:TDE_2194"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2071"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_12"/>
    <dbReference type="OMA" id="PFFRVHE"/>
    <dbReference type="OrthoDB" id="479874at2"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008890">
        <property type="term" value="F:glycine C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010962">
        <property type="entry name" value="AONS_Archaea/Firmicutes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004723">
        <property type="entry name" value="AONS_Archaea/Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00858">
        <property type="entry name" value="bioF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01825">
        <property type="entry name" value="gly_Cac_T_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0093">Biotin biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000381130" description="8-amino-7-oxononanoate synthase">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="209"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="240"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="395" mass="43001" checksum="77659D565DDA5D12" modified="2004-07-05" version="1">MSNIHDMEFLQKKVQELKEQGLYKELVTLEGPSDAECVINGKKVINLSSNNYLGFANHPRLKKAAIEAIEKYGAGAGAVRPIIGNMKIHDDLEKLLAEFKREEAVLAFQSGFNCNAGVIQALTDKGDLIISDQLNHASIIDGTRLSKADKAVFQHSDMADLERVLKEKRNNYNNVLIITDGVFSMDGDIAKLPEIVALAEKYNCLTYVDDAHSSGVLGESGRGTVDHFKLHGRVDVAMGTLSKAIGVVGGYVAGKKVTIDWLKNRGRPFLFSTGLPPAAVGAAIEAVKMLMESTEYTDKLWANAKHFKEGLGKLGYNIGHSETPITPIIIGDEAKTLEFSKKLFENGLFSGPIVFPTVPKGTGRVRCMVTAGHTTEQLDRAVKICEKVGKEMGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KS8</accession>
    <name>Q73KS8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972740.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679957.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2139"/>
    <dbReference type="EnsemblBacteria" id="AAS12659">
        <property type="protein sequence ID" value="AAS12659"/>
        <property type="gene ID" value="TDE_2139"/>
    </dbReference>
    <dbReference type="GeneID" id="2739398"/>
    <dbReference type="KEGG" id="tde:TDE_2139"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2020"/>
    <dbReference type="HOGENOM" id="CLU_1065342_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284565" evidence="1">
        <location>
            <begin position="21"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="261" mass="29933" checksum="062909052B18C910" modified="2004-07-05" version="1">MKSKLMILCLSLLLTACAPKESQEIFVKKIDHFMLTCKEPKELYNMLVYTFDLPIAWPYRSMGTFTSGGVEFGNCVLEAIDFKIEEDISGIIGMAFEPAMKVSDIQDRLREKGFKETNLYSNQYWKNLICNDLSTGGTVFFCEYQIPVKKTEKEPGGNLGLRYVEKVKIAYSDYNKALDLWRKLLVPHKETKEGLWEIESSPNIEIIKSDYDGFISFEVKVKSLEKVRSFLSEKDLIGEDTGSSVYTDPKKTYGVLFEFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KT2</accession>
    <name>Q73KT2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972736.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679949.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2135"/>
    <dbReference type="EnsemblBacteria" id="AAS12655">
        <property type="protein sequence ID" value="AAS12655"/>
        <property type="gene ID" value="TDE_2135"/>
    </dbReference>
    <dbReference type="GeneID" id="2739394"/>
    <dbReference type="KEGG" id="tde:TDE_2135"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2016"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071023_2_0_12"/>
    <dbReference type="OMA" id="YIFENIC"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="250" mass="29525" checksum="1531C53EEB689EC5" modified="2004-07-05" version="1">MIKRFEDLTLQDDFMFCKVMQNPDLCKRLIEMILSDTIGKITYISIQHNIKNYEQAKSVRFDVLVQTENGKFYDIEMQVSNEKNTPKRMRFYQAAIDISFLDKGNSYNNLNDSFIIFICTFDAIGKNRPIYIFENICIEDKNISLQDRTKKVIINSEAFENTEDKELKEFLEYLKTGKAKSEFTREIEAMIQTIKQNEQARQEYRLMSTFEMDIKDSVKRETAKLMKQKNFDIALIKEITGLPETEIEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KT9</accession>
    <name>Q73KT9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972729.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957157.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2128"/>
    <dbReference type="EnsemblBacteria" id="AAS12648">
        <property type="protein sequence ID" value="AAS12648"/>
        <property type="gene ID" value="TDE_2128"/>
    </dbReference>
    <dbReference type="GeneID" id="2739387"/>
    <dbReference type="KEGG" id="tde:TDE_2128"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2011"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_13_3_12"/>
    <dbReference type="OMA" id="GMWAVAM"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="429" mass="48576" checksum="422CA295DBF15660" modified="2004-07-05" version="1">MQIKKRTEKRNLFLIYFGTITSLIGDEIGSVAISIWVALQTDNPINFALVYSAAKFSRIVFSLFSGSIVDSFNKKKILYLSDSAQFVLNIFILFLILLNLDFKLKVFLFCLISFLQGFCLSIFKPSSRAILPEIINKENLKKANSVLEMSKSLISMLAVIFAAGLVMLLGCEVCILINALTFFISALSEIFIRYDFKKKDEQKKMESKLKKIFDGYRYVLSEKELLRFALLGSCLNFFCTPIFSNILTYQFKTVFMFNWQSTFPFLNKFLKDEKSFLALLSTIVFFGLGIGNILGSLASRKVSGKNIKFFALVLPAFSFLILGFYFWFLKENNFLFNVILLGSIISSSALLAGFSMGVFNVYVTSLYQKKVRSEFSGRFFAFNTVLIQISSPIGMLIGSSIAAIGIFYPVFLFAGGILFFSYIVYCRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L69</accession>
    <name>Q73L69_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4065 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972599.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957123.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1996"/>
    <dbReference type="EnsemblBacteria" id="AAS12510">
        <property type="protein sequence ID" value="AAS12510"/>
        <property type="gene ID" value="TDE_1996"/>
    </dbReference>
    <dbReference type="GeneID" id="2740449"/>
    <dbReference type="KEGG" id="tde:TDE_1996"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1884"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107055_0_0_12"/>
    <dbReference type="OMA" id="VSMPHGP"/>
    <dbReference type="OrthoDB" id="1702165at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025272">
        <property type="entry name" value="SocA_Panacea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13274">
        <property type="entry name" value="DUF4065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4065" evidence="1">
        <location>
            <begin position="26"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="186" mass="21258" checksum="A31C81A7DC63748E" modified="2004-07-05" version="1">MNIHKLIEVVNYMLKKYEYRLNYTKLLKMLYLADRQSYDDTGSPITGDTYTALKAGPILSNTYNLIRNKGNQNDQNLWNSRFLKDAYDLVALTDKIPCNTLSDYEKEVLDGIDSKFHNYTFTDLIEYTHANCPEWKAPKDSALPISIESILQALGKSPDEIAFIIEEEESFAQEEAALAQLSELNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L72</accession>
    <name>Q73L72_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aspartate ammonia-lyase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972596.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679739.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1993"/>
    <dbReference type="EnsemblBacteria" id="AAS12507">
        <property type="protein sequence ID" value="AAS12507"/>
        <property type="gene ID" value="TDE_1993"/>
    </dbReference>
    <dbReference type="GeneID" id="2740446"/>
    <dbReference type="KEGG" id="tde:TDE_1993"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1882"/>
    <dbReference type="eggNOG" id="COG1027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_12"/>
    <dbReference type="OMA" id="EICENYV"/>
    <dbReference type="OrthoDB" id="734949at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="2">
        <location>
            <begin position="406"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="463" mass="50783" checksum="6A17E234DB99FD7B" modified="2004-07-05" version="1">MRREHDLLGELDIPEDAYYGIQTFRSVENFQITGLRLCDFPDFIKGLAYTKQAAAEANHELGYLSDEVYKAMIQACKEVAEGKFDKEFVVDMIQGGAGTSTNMNANEVIANRANEILGKAKGTYSPCHPNNHVNFAQSTNDAYPTAAKLGISLNTPALIDELKSLVASFRKKAQELGENIKMGRTQLQDAVPMTLGQEFESYAASLENEIPQIQFARENLHTINMGATAIGTGINSDPNYTPKVTSHLAKISGLDLKAAKNMIAATNDTSDFVTYSSQLKRLSAKLSKICSDLRLLSSGPRTGLYDISLPPMQPGSSIMPGKVNPVIPEVVNQVCYRVIGNDTAVILAAESGQLELNVFEPVIIYSIFESIKLLINAMKTLRERCVTGIVGNYEHCKESVHRSIGLVTALNPVIGYEASSDIAKTALRDNRSVYDLVLERGLLSKEKLDEVLKPENMTKPRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LC9</accession>
    <name>Q73LC9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972539.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679651.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1936"/>
    <dbReference type="EnsemblBacteria" id="AAS12450">
        <property type="protein sequence ID" value="AAS12450"/>
        <property type="gene ID" value="TDE_1936"/>
    </dbReference>
    <dbReference type="GeneID" id="2740176"/>
    <dbReference type="KEGG" id="tde:TDE_1936"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1829"/>
    <dbReference type="HOGENOM" id="CLU_2902974_0_0_12"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="62" mass="7095" checksum="35BA534AAB1693D2" modified="2004-07-05" version="1">MVVDEKSGNPILLSQKAYRAIRNCRTTPCDVIVNDVLNFDERIKRPTLEKTVSTEGILIYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LD7</accession>
    <name>Q73LD7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AP_endonuc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972531.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669752.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1928"/>
    <dbReference type="EnsemblBacteria" id="AAS12442">
        <property type="protein sequence ID" value="AAS12442"/>
        <property type="gene ID" value="TDE_1928"/>
    </dbReference>
    <dbReference type="GeneID" id="2740168"/>
    <dbReference type="KEGG" id="tde:TDE_1928"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1823"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1106722_0_0_12"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="AP_endonuc_2" evidence="2">
        <location>
            <begin position="61"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="251" mass="29126" checksum="4DAE0C3DED15F27E" modified="2004-07-05" version="1">MKNKLIKAVRTIADFDLNLFNELNLGLELQDFTEPCLTDSEIYSLLNEYEKKLPSLKGIKSMHGSFIDLNIASFNRDIAAYSRKMYKRDLFFAKLLNLDFIIFHTQIMPWFKEDFKFDLFLKSNAEFFNEAVENSGFKGCVVLENVCEKDSSLTAKLIEAVALPQVKLNLDWGHALISGEKIESWFSNNQKHIAYMHLHSNDGKNDLHNPVSKEDFAKLSDLLEKYGLNCPICLEYWDIDIKKEMERISLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LF5</accession>
    <name>Q73LF5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dacA</name>
        <name evidence="12" type="ordered locus">TDE_1909</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972512.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669723.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1909"/>
    <dbReference type="EnsemblBacteria" id="AAS12423">
        <property type="protein sequence ID" value="AAS12423"/>
        <property type="gene ID" value="TDE_1909"/>
    </dbReference>
    <dbReference type="GeneID" id="2740407"/>
    <dbReference type="KEGG" id="tde:TDE_1909"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1807"/>
    <dbReference type="eggNOG" id="COG1624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038561_0_1_12"/>
    <dbReference type="OMA" id="ILWQGEL"/>
    <dbReference type="OrthoDB" id="1300262at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045585">
        <property type="entry name" value="CdaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19293">
        <property type="entry name" value="CdaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="85"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS12423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="274" mass="30475" checksum="EA72812C8EE65897" modified="2004-07-05" version="1">MEFIRNITAFYSSYLRPVFDVLLLAFLMYKAYQILLKTQAIQLIKGAMSILVIYAVAMIFNLKTLLWLLNTLGPGLVIGVAIVFQPELRKIFLKIGQSNWLRTGKHSNHSHIDSVVTAAEILSDKRRGMLVVFMRRNNLKDIIDTGTKLNAGLSSSLLVTIFGHDTPLHDGAAIVQNGMIVSAGCFLPLSEQQDIRKSFGTRHRAAIGVSEETDAVVLVVSEETGALSLAYDSHLYYDLSADEVVAQLEQLLEIKKYFAQEESLDLAEALQDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LK1</accession>
    <name>Q73LK1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972465.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12376">
        <property type="protein sequence ID" value="AAS12376"/>
        <property type="gene ID" value="TDE_1861"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1861"/>
    <dbReference type="HOGENOM" id="CLU_2670003_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="75" mass="8055" checksum="DB94206C9DF4FBE8" modified="2004-07-05" version="1">MCEPFIGYLNNLIIASIIKAGIPRTIAPANKTGISQKTSLNARTKIPPTIPKTAAIIPKTKTIIKKAINIFPSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LQ4</accession>
    <name>Q73LQ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972412.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957058.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1808"/>
    <dbReference type="EnsemblBacteria" id="AAS12323">
        <property type="protein sequence ID" value="AAS12323"/>
        <property type="gene ID" value="TDE_1808"/>
    </dbReference>
    <dbReference type="GeneID" id="2739238"/>
    <dbReference type="KEGG" id="tde:TDE_1808"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1720"/>
    <dbReference type="eggNOG" id="ENOG50342EW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_846789_0_0_12"/>
    <dbReference type="OMA" id="CHFTRDI"/>
    <dbReference type="OrthoDB" id="2138811at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="321" mass="36758" checksum="F5A37A6844E7B405" modified="2004-07-05" version="1">MQDTIESILKDLFSVDFKKVSNELCVDMYNSLSNSLSANKNEVSIVTELCSVIDNRKYKKFSFHAKKIHGKASNVEFKNKNRVTVKELSDMAVISILTDNKKILFEKTAFIQNKKEIGQNKWDIEQDQLFLLRNFPTFIPKTGLLRRLKNNNVILINRTKSLGNYGLFQKPGEMIIVNAETIFTTQKNGNVVYNDLLSASQHTISSSNIFWLPYYDDFICDLFHYLYRFQLSICNKGIIPFIDTCPISLNIYDVIQNLVNFNIGEVASINSNIINSDLAEINNVLLNSIGLRFENFVISEDPEFESNIAVLVFQIDIGNME</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LQ6</accession>
    <name>Q73LQ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972410.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957057.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1806"/>
    <dbReference type="EnsemblBacteria" id="AAS12321">
        <property type="protein sequence ID" value="AAS12321"/>
        <property type="gene ID" value="TDE_1806"/>
    </dbReference>
    <dbReference type="GeneID" id="2739236"/>
    <dbReference type="KEGG" id="tde:TDE_1806"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1718"/>
    <dbReference type="eggNOG" id="ENOG502ZV1P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140900_2_0_12"/>
    <dbReference type="OMA" id="NHEINYE"/>
    <dbReference type="OrthoDB" id="1855549at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025528">
        <property type="entry name" value="BrnA_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14384">
        <property type="entry name" value="BrnA_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="90" mass="10333" checksum="F345F5403E59EC49" modified="2004-07-05" version="1">MITSKKLTAERLEEIKNYPISYDEDSPKLTKEQIARLRPVHEAYWNVTPIKKKISIKIDADILAVLQSLGKGYQTRINSILREAITTGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LR8</accession>
    <name>Q73LR8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972398.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957048.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1794"/>
    <dbReference type="EnsemblBacteria" id="AAS12309">
        <property type="protein sequence ID" value="AAS12309"/>
        <property type="gene ID" value="TDE_1794"/>
    </dbReference>
    <dbReference type="GeneID" id="2741238"/>
    <dbReference type="KEGG" id="tde:TDE_1794"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1707"/>
    <dbReference type="HOGENOM" id="CLU_423317_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="647" mass="75426" checksum="42A1D2ECD9822E9B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LS9</accession>
    <name>Q73LS9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972387.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1783"/>
    <dbReference type="EnsemblBacteria" id="AAS12298">
        <property type="protein sequence ID" value="AAS12298"/>
        <property type="gene ID" value="TDE_1783"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1783"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1697"/>
    <dbReference type="HOGENOM" id="CLU_212846_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="55" mass="6380" checksum="68E04D4985438BBF" modified="2004-07-05" version="1">MGADYKRVKLEVYSFNKNIEDNKKFTEDIKELGVQHQNNDIIPSILKANKIDKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LT2</accession>
    <name>Q73LT2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972384.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1780"/>
    <dbReference type="EnsemblBacteria" id="AAS12295">
        <property type="protein sequence ID" value="AAS12295"/>
        <property type="gene ID" value="TDE_1780"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1780"/>
    <dbReference type="HOGENOM" id="CLU_3278173_0_0_12"/>
    <dbReference type="OrthoDB" id="2210742at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="41" mass="4779" checksum="98F53A7921089546" modified="2004-07-05" version="1">MLNHYSDSILLTDDEGSIKIIKEFDEELYGFLISLRMDNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LU4</accession>
    <name>Q73LU4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972372.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669505.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1768"/>
    <dbReference type="EnsemblBacteria" id="AAS12283">
        <property type="protein sequence ID" value="AAS12283"/>
        <property type="gene ID" value="TDE_1768"/>
    </dbReference>
    <dbReference type="GeneID" id="2740613"/>
    <dbReference type="KEGG" id="tde:TDE_1768"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1688"/>
    <dbReference type="HOGENOM" id="CLU_2412286_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="92" mass="11351" checksum="D7FCFD589B8C0E5C" modified="2004-07-05" version="1">MINYIHGGYLSEFEEYILIKVNNGKIIEQGKYNLENYKNKKQQAFERFYGSAKYNESWNSIKNNFEDNIEENYKKEIMKDCEYLYLYDFYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LV9</accession>
    <name>Q73LV9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE</name>
        <name evidence="10" type="ordered locus">TDE_1753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972357.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679490.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1753"/>
    <dbReference type="EnsemblBacteria" id="AAS12268">
        <property type="protein sequence ID" value="AAS12268"/>
        <property type="gene ID" value="TDE_1753"/>
    </dbReference>
    <dbReference type="GeneID" id="2740598"/>
    <dbReference type="KEGG" id="tde:TDE_1753"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1676"/>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_12"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="OrthoDB" id="1597849at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="9">
        <location>
            <begin position="6"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS12268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="339" mass="37240" checksum="2E8618A68F5CEA8D" modified="2004-07-05" version="1">MIKRVLVTGGAGFIGSHIVADLCEKGYEPIILDNFSNSSPKIIPVLEKICSKKLELVQIDIKDKEKLFNFFKSTSIDAVIHLAAYKAVGESVEKPLKYYENNISGLVNLLLAMQEHKVKNFIFSSSATVYGDAKVVPIPENSPISAANPYGRTKLMSEEILKDTAFSDKDLSIIALRYFNPIGAHKSADIGELPSGIPNNLFPYIAQVALGKLPHLNVFGNDYDTPDGTCIRDYIHILDLASGHTVAIEKIASGFKGFDVYNLGTGIGYSVLDIVNAFKKASGIDLPVKPAARRAGDVPRSCANPDKANKELNWKAKYNLEEMCKDGWAWYKKHPEGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LZ9</accession>
    <name>Q73LZ9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972317.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670926.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1713"/>
    <dbReference type="EnsemblBacteria" id="AAS12228">
        <property type="protein sequence ID" value="AAS12228"/>
        <property type="gene ID" value="TDE_1713"/>
    </dbReference>
    <dbReference type="GeneID" id="2740885"/>
    <dbReference type="KEGG" id="tde:TDE_1713"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1638"/>
    <dbReference type="HOGENOM" id="CLU_133297_0_0_12"/>
    <dbReference type="OrthoDB" id="1899700at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="152" mass="17705" checksum="AFA6D0744B8E0917" modified="2004-07-05" version="1">MNYIKTKIIAAFLLIVIIIVVLFTSVLNKKYDRYVMFFKNSITGKIDTEIRYVPIQNIMEPEAAFFEELMLGPVNHYCYSFIRAGSKLLSCFVKEGVLYADLPVVFIEDIKQELDSDEIRYLLQKNIFTNCKDLKAAHIFVEGIEIYELLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M01</accession>
    <name>Q73M01_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RelA/SpoT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972315.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1711"/>
    <dbReference type="EnsemblBacteria" id="AAS12226">
        <property type="protein sequence ID" value="AAS12226"/>
        <property type="gene ID" value="TDE_1711"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1711"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1636"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676041_0_0_12"/>
    <dbReference type="OMA" id="LVYKAEF"/>
    <dbReference type="OrthoDB" id="1938730at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="2">
        <location>
            <begin position="29"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="388" mass="45157" checksum="1115B82F8C63753F" modified="2004-07-05" version="1">MPHLNILIVRIEEFLRSIVKITSAPTYKTRVKSFNSYYLKLLKFPPKKDTSDLPVLTDILGVRIICPFLQDINEVERILLKNFKIIEVERKGSERTFREFGYESVHFLLDIPEEFKVGLVLPKNLIFEIQLRTILQDAWAEVEHELVYKSEFSPFDQPLKRKLASINASLSLADIIFQEIRDYQNKLNAELEKRRFEFYSMADEYTAQVLPETNIVQHDNVEHGEELKLAETIDDLILSAIEAHNQNLFDKAEKIYTKIIEQNPNDIVLSVVYKHRGMAYFAQANYEGAYADFLQSCKYNSANFRSFYYVGIALTLLNRDDEAIEYFTKSLEINKFQAHVYFRRALSYFKLALYPEAARDLDSASDLGLAEEDAKKLRIAIAKKIDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M07</accession>
    <name>Q73M07_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972308.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679411.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1704"/>
    <dbReference type="EnsemblBacteria" id="AAS12219">
        <property type="protein sequence ID" value="AAS12219"/>
        <property type="gene ID" value="TDE_1704"/>
    </dbReference>
    <dbReference type="GeneID" id="2740876"/>
    <dbReference type="KEGG" id="tde:TDE_1704"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1629"/>
    <dbReference type="eggNOG" id="ENOG5030V73">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1509966_0_0_12"/>
    <dbReference type="OrthoDB" id="2117301at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284594" evidence="1">
        <location>
            <begin position="25"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="178" mass="20843" checksum="0D654D1C92801BF3" modified="2004-07-05" version="1">MILKRKKNIFICVLFCIFLVQIYANDVSEVKINDGPIILRGKKFEFYKTHTKEDIEKKIGKPTFYRHKPGRYDVVYEDDGFIISLTNDGIFEYIGINFEIVHRADVKGFIIERGNTYSQIIKKLEKKKLDFTVKDSDNSIYITVKFFTKNIGNTQLEIWLPDKKNSEVIGLIYARADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M10</accession>
    <name>Q73M10_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
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            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="243275.TDE_1701"/>
    <dbReference type="EnsemblBacteria" id="AAS12216">
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    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="375" mass="39841" checksum="62359BCC98963C46" modified="2004-07-05" version="1">MDDLMNVVGGDTTINTRGIDVCNPSPEPDYIIDDDGNHHHAPSPSPTNPKPAPGTGNPGNPPNTGNDGDGGGDSKDPTEDTPSDPGNPVNDDGGNGSSGGTPDNGDDETGGNTNLPTDDDGDIGNGSVGNGGQTTTPPAANINTTQTTQAADVSPKPVSPAERARSILANLTNPIEQTVNAKTGCKNDMLAAYYDDKLTNKKLSFDASYKEVQDDLPMQKDKNGKVIYPNTCKYNSTIGAVRLSGYTYKDDLTKEDVEKITNKAVSSKKCKLHTDVIKEVFGLDAVYYEIPAGLSEKELKALVGDNPAMIRFPQRAFWGNDKLPEDGEHGIGYVNGGFIEPYMGRHGESWKDVRGARSTADFTSNLGGLYFEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M49</accession>
    <name>Q73M49_TREDE</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ordered locus">TDE_1661</name>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12177.1"/>
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    <dbReference type="RefSeq" id="WP_002671005.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="gene ID" value="TDE_1661"/>
    </dbReference>
    <dbReference type="GeneID" id="2739002"/>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.1588"/>
    <dbReference type="eggNOG" id="COG4704">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125018_2_2_12"/>
    <dbReference type="OMA" id="FVYQDIN"/>
    <dbReference type="OrthoDB" id="2066470at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018673">
        <property type="entry name" value="DUF2141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09912">
        <property type="entry name" value="DUF2141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="142" mass="16273" checksum="F450E9B860E44E6D" modified="2004-07-05" version="1">MKKIIFIFTILLTVFTGLYSEETGPEFEVTLNITNIETIEGKLFLSIYQDAQSFKKKEPLKTVSVQVDGKEMTITEKLPQGEYVFFVYQDINKNDKLDRNFLGMPKEPVGYGNHKGGRPGGFNKLKIEIKENKSVDIKLFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M57</accession>
    <name>Q73M57_TREDE</name>
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            <fullName evidence="8">ABC transporter, ATP-binding/permease protein</fullName>
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    <gene>
        <name evidence="8" type="ordered locus">TDE_1652</name>
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    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972258.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679340.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1652"/>
    <dbReference type="EnsemblBacteria" id="AAS12169">
        <property type="protein sequence ID" value="AAS12169"/>
        <property type="gene ID" value="TDE_1652"/>
    </dbReference>
    <dbReference type="GeneID" id="2738993"/>
    <dbReference type="KEGG" id="tde:TDE_1652"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1578"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_496893_0_0_12"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="83"/>
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            <begin position="135"/>
            <end position="159"/>
        </location>
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            <end position="184"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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            <end position="382"/>
        </location>
        <ligand>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="555" mass="61542" checksum="EDC171F744C47DA6" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M80</accession>
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        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
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    </protein>
    <gene>
        <name evidence="16" type="primary">lpdA</name>
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        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972235.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679315.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1629"/>
    <dbReference type="EnsemblBacteria" id="AAS12146">
        <property type="protein sequence ID" value="AAS12146"/>
        <property type="gene ID" value="TDE_1629"/>
    </dbReference>
    <dbReference type="GeneID" id="2739738"/>
    <dbReference type="KEGG" id="tde:TDE_1629"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1557"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_3_12"/>
    <dbReference type="OMA" id="HMVGDRM"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="2"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="331"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="303"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="39"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AAS12146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="453" mass="48416" checksum="AA06E397E5C0B7C2" modified="2004-07-05" version="1">MYDLIVLGGGPGGYVAAIKAGRAGLKTALIEKNRLGGTCLNKGCIPTKYLLHTAEVFGSFAENDLGLSGENLKYDIKAIYEKKNAVVDKLVGGIEKLIENAGVDFYNGEGKITSKSSVSVNGKELEFKNLIIATGSSVFAPPIAGIETAMTSDDILGKEPVDFKSVIIIGGGVIGIEFATVYANLGKEVTIVELEKTILPPFDRDIAMQQAIVLKKRGVKIINGAMVTKIEKTGCTFTLKEKEESITADAVIVCIGRIAEIKDIGLDSAGIEYDKRGIITDACMKTNVEGIYAIGDAVKGNVMLAHNAENQGHLVVENIVNNTKHEKQDVIPSCVYSTPEIAGVGLSEKEAEAKGITVKIGKVPMGSNGKSVLSGLDVGFIKVLFNEEDRIVGCQMMCDSATDMIGAIGTLVTNKAKRENILKSMYPHPTVVEAFYEAVEDVEKSATHMIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MA8</accession>
    <name>Q73MA8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972207.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679286.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1601"/>
    <dbReference type="EnsemblBacteria" id="AAS12118">
        <property type="protein sequence ID" value="AAS12118"/>
        <property type="gene ID" value="TDE_1601"/>
    </dbReference>
    <dbReference type="GeneID" id="2740842"/>
    <dbReference type="KEGG" id="tde:TDE_1601"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1531"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_6_0_12"/>
    <dbReference type="OMA" id="ECFIGEY"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="215" mass="24900" checksum="28EB5868AE780D7F" modified="2004-07-05" version="1">MSYCSDITKNRILECAKEEFLRNGFEKAQVGEIAKTANVTTGAIYRHFKNKEELFFTLIEDVYEYTLDIVTDVEIRSTDKASMPLSEETDNVVIEALFSETMRFVDYMYEHFDEFKLLLACSKGSRVENFAEEIADRYTHKNMKLIQATAGKKSSATKIKELEVHIITKGYITSLCECIIHAIPYNDVSRYIKSIVTFQYYGWGGLLNELRIYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MB6</accession>
    <name>Q73MB6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fe-hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_1593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972199.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671107.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1593"/>
    <dbReference type="EnsemblBacteria" id="AAS12110">
        <property type="protein sequence ID" value="AAS12110"/>
        <property type="gene ID" value="TDE_1593"/>
    </dbReference>
    <dbReference type="GeneID" id="2739790"/>
    <dbReference type="KEGG" id="tde:TDE_1593"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1523"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018240_2_1_12"/>
    <dbReference type="OMA" id="CMRCIQV"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036991">
        <property type="entry name" value="Fe_hydrogenase_ssu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013352">
        <property type="entry name" value="Fe_hydrogenase_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02256">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00902">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02512">
        <property type="entry name" value="FeFe_hydrog_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="8">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="596" mass="66659" checksum="B2DEC88EAFEB6B03" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MC3</accession>
    <name>Q73MC3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972192.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679263.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1586"/>
    <dbReference type="EnsemblBacteria" id="AAS12103">
        <property type="protein sequence ID" value="AAS12103"/>
        <property type="gene ID" value="TDE_1586"/>
    </dbReference>
    <dbReference type="GeneID" id="2739783"/>
    <dbReference type="KEGG" id="tde:TDE_1586"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1516"/>
    <dbReference type="eggNOG" id="ENOG5032TWX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1730617_0_0_12"/>
    <dbReference type="OMA" id="DTECSLY"/>
    <dbReference type="OrthoDB" id="1840462at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="160" mass="17583" checksum="33257C74C555B9F9" modified="2004-07-05" version="1">MKHTYKTRIYRVLVNAAMGLALAVIVSFIVGFFIPSNIVRALVFIAILAGYVWLVIINNIITIEVDDKTLTIKKGKKTDIYDIATTAVRAKIVTSTYGRSSAGSDTECSLYLTRPGEEEVLVDCELIGISHFNELLENLGITGDSVAKLDTENTTEKHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MH2</accession>
    <name>Q73MH2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972142.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671188.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1536"/>
    <dbReference type="EnsemblBacteria" id="AAS12053">
        <property type="protein sequence ID" value="AAS12053"/>
        <property type="gene ID" value="TDE_1536"/>
    </dbReference>
    <dbReference type="GeneID" id="2740898"/>
    <dbReference type="KEGG" id="tde:TDE_1536"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1473"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003728_14_0_12"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="PTHR15704"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="174" mass="19885" checksum="39EDCEE636375C87" modified="2004-07-05" version="1">MQESAQFFNDTGVSMSMQGFHNEAIACLKKGLALEPDNSLMWLNLGLSYYAAKRQNDSKFALFQSLKYNPYEADAWDSLGLVLFETGDIDQAERAFESAIKLEPENGRVWNNYGTVLFNKENYRAARRAFESAVTLDPEMGDAVFNLRDTYLELGMNDLAERCNKILKEMDYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MK2</accession>
    <name>Q73MK2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-serine dehydratase</fullName>
            <ecNumber evidence="1">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sdhA</name>
        <name evidence="3" type="ordered locus">TDE_1506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-sulfur dependent L-serine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972112.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671221.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1506"/>
    <dbReference type="EnsemblBacteria" id="AAS12023">
        <property type="protein sequence ID" value="AAS12023"/>
        <property type="gene ID" value="TDE_1506"/>
    </dbReference>
    <dbReference type="GeneID" id="2739712"/>
    <dbReference type="KEGG" id="tde:TDE_1506"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1445"/>
    <dbReference type="eggNOG" id="COG1760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022305_2_0_12"/>
    <dbReference type="OMA" id="FVEVPCV"/>
    <dbReference type="OrthoDB" id="225730at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004642">
        <property type="entry name" value="Ser_deHydtase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00718">
        <property type="entry name" value="sda_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDH_alpha" evidence="2">
        <location>
            <begin position="19"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="296" mass="30464" checksum="8E21A946E45482A2" modified="2004-07-05" version="1">MKTIEYKKIEDLIQKAAENSLRISDIILEDQSSALEETKEQCFERMQEHLNVMLEAIDKGTNPDIRSTSGLTGGDAYKIYERSENGKALCGPLLANGIRMAMAVSELNASMGKIVAAPTAGSCGILPGAIGAVLKTKDVKKEDAVMSLFTAGAIGMVIANTASISGAEGGCQAECGSASAMAAGAIVEMCGGTPEMVGHATAIALKCILGLVCDPVAGLVEVPCVKRNASGVSLAFTAAELALAGIKSAIPVDEVIIAMKKVGDSIPSALRETAEGGLACTATGKRLQKEIFGKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MK7</accession>
    <name>Q73MK7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ppdK</name>
        <name evidence="15" type="ordered locus">TDE_1501</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972107.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679160.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1501"/>
    <dbReference type="EnsemblBacteria" id="AAS12018">
        <property type="protein sequence ID" value="AAS12018"/>
        <property type="gene ID" value="TDE_1501"/>
    </dbReference>
    <dbReference type="GeneID" id="2739902"/>
    <dbReference type="KEGG" id="tde:TDE_1501"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1440"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015345_0_2_12"/>
    <dbReference type="OMA" id="RRFVQMY"/>
    <dbReference type="OrthoDB" id="997616at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="13">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="13">
        <location>
            <begin position="317"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="12">
        <location>
            <begin position="439"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="14">
        <location>
            <begin position="538"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="896"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="910"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="853"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="764"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="785"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="786"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="787"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AAS12018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="933" mass="102429" checksum="0E657D88FECACDD0" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MN0</accession>
    <name>Q73MN0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972084.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668953.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1478"/>
    <dbReference type="EnsemblBacteria" id="AAS11995">
        <property type="protein sequence ID" value="AAS11995"/>
        <property type="gene ID" value="TDE_1478"/>
    </dbReference>
    <dbReference type="GeneID" id="2741593"/>
    <dbReference type="KEGG" id="tde:TDE_1478"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1417"/>
    <dbReference type="eggNOG" id="ENOG5031CDJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1539354_0_0_12"/>
    <dbReference type="OMA" id="WFNIFEI"/>
    <dbReference type="OrthoDB" id="1471418at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="180" mass="21054" checksum="FCA3135E1BD2C72E" modified="2004-07-05" version="1">MNNDEILFPLLEKGDIKRTMELASNENKKPFEIVSEGMNIVTASILADIPSVYKMDLIRKVGALFSTQEYCELLNQKMFTLKPEERDKLKDQGILINRETTLPYCQWFNIFEIAFPWLPLSVFEDFALYLRDEKKLILDKETIEIVRDNFSISKRYSERELSRLFDSNALKDPADIDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MQ5</accession>
    <name>Q73MQ5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972059.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679111.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1453"/>
    <dbReference type="CAZy" id="GH36">
        <property type="family name" value="Glycoside Hydrolase Family 36"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11970">
        <property type="protein sequence ID" value="AAS11970"/>
        <property type="gene ID" value="TDE_1453"/>
    </dbReference>
    <dbReference type="GeneID" id="2741416"/>
    <dbReference type="KEGG" id="tde:TDE_1453"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1394"/>
    <dbReference type="eggNOG" id="COG3345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009640_2_1_12"/>
    <dbReference type="OMA" id="FNSWEAT"/>
    <dbReference type="OrthoDB" id="131906at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002252">
        <property type="entry name" value="Glyco_hydro_36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031704">
        <property type="entry name" value="Glyco_hydro_36_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16875">
        <property type="entry name" value="Glyco_hydro_36N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005536">
        <property type="entry name" value="Agal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00743">
        <property type="entry name" value="GLHYDRLASE36"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_36N" evidence="6">
        <location>
            <begin position="26"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="363"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="473"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="774" mass="89011" checksum="6E6D053D215613B9" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MW3</accession>
    <name>Q73MW3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971999.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671401.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1393"/>
    <dbReference type="EnsemblBacteria" id="AAS11910">
        <property type="protein sequence ID" value="AAS11910"/>
        <property type="gene ID" value="TDE_1393"/>
    </dbReference>
    <dbReference type="GeneID" id="2741260"/>
    <dbReference type="KEGG" id="tde:TDE_1393"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1335"/>
    <dbReference type="eggNOG" id="ENOG5032I09">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1377595_0_0_12"/>
    <dbReference type="OMA" id="REFFAFG"/>
    <dbReference type="OrthoDB" id="1834273at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="197" mass="22127" checksum="E43CAC030285635C" modified="2004-07-05" version="1">MAANKKLIVFLFGLCPIIPAASNFAYGIVLTVSLWVIFFLGILGNYVGKLIDINRFNYVFVSIFMITGTALVNALLEGILPIIHGPLQVYTYILTFSYIIFLGLKQYYEDSESLDLPIWYSVLILSLSALREFFAFGSLSFPVSSGFLSLRLPYFSNHPLFRFLGTTAGAFIILGLIIWIYFSVTKELPTVKMGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N07</accession>
    <name>Q73N07_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mreB</name>
        <name evidence="3" type="ordered locus">TDE_1349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971955.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668696.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1349"/>
    <dbReference type="EnsemblBacteria" id="AAS11866">
        <property type="protein sequence ID" value="AAS11866"/>
        <property type="gene ID" value="TDE_1349"/>
    </dbReference>
    <dbReference type="GeneID" id="2739450"/>
    <dbReference type="KEGG" id="tde:TDE_1349"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1297"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_12"/>
    <dbReference type="OMA" id="MVICIPS"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="161"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="209"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="289"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="344" mass="37157" checksum="E9FB113D6AE0936F" modified="2004-07-05" version="1">MGFFKRFSTDIGIDLGTCNTIIYVNGKGIVVNEPSVVAVERGTKRVVAVGSEAKRMLWKTPGNIVAIRPLKDGVIADMDTTEKMIRYFVSKILPKHRFVKPRMVIGIPSCITDVESNAVYESAMKAGAGDVKVLEESLVAAIGANIPIHEPAGNMVCDIGGGTTEVSVISLCGMVVTNAIRVGGDEFDQAIIKHVRSVDNLIIGEQTAERVKISIGNASPEKTIEKVEIKGTDAITGLPRRLEIDSVEVREALKEPVTQIVEEIKRTLAQTPPELTADIVERGIVMTGGGSLLKGLPKLIAKEARVPVILAENPMDCVAIGAGRYYEVFRDMTVDRSLYDSLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N34</accession>
    <name>Q73N34_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971928.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678867.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11839">
        <property type="protein sequence ID" value="AAS11839"/>
        <property type="gene ID" value="TDE_1322"/>
    </dbReference>
    <dbReference type="GeneID" id="2739580"/>
    <dbReference type="KEGG" id="tde:TDE_1322"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1271"/>
    <dbReference type="eggNOG" id="ENOG5030V9B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101808_0_0_12"/>
    <dbReference type="OMA" id="MSSFIQM"/>
    <dbReference type="OrthoDB" id="2114470at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="238" mass="27598" checksum="2964E94F5A310C5C" modified="2004-07-05" version="1">MKTKHGIIFLSLGIFIFSSCITVKYYGTDTTAFETKYFGNIIEFKKSAVADSNDIILNGKEDFRLGFDPLYPNEVDLMKWTGKIWFNDIFYDIQINYRQKKGNYGIENIRKVDIQNLPPIYKFEKFNISGSQAIWEKSVHESELPVKLATFSVENVEFYVLLTSMYTVATMKDNMSSFIQMVKSKDQVFHIVSSDGIIYAEFTKDKYKLFEVNNSKLDSKKLWPCIAVFSIVRIICSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N37</accession>
    <name>Q73N37_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971925.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678862.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1319"/>
    <dbReference type="EnsemblBacteria" id="AAS11836">
        <property type="protein sequence ID" value="AAS11836"/>
        <property type="gene ID" value="TDE_1319"/>
    </dbReference>
    <dbReference type="GeneID" id="2739577"/>
    <dbReference type="KEGG" id="tde:TDE_1319"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1268"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056728_0_0_12"/>
    <dbReference type="OMA" id="LINTYTE"/>
    <dbReference type="OrthoDB" id="1965031at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="390" mass="43965" checksum="99FE5999595B6D8A" modified="2004-07-05" version="1">MKRIAFVLVFIFCVFSIFAVDQDELLNLRKDFISAGIDVKAVILRSLSQSEDKSLIPIYQDAVEYVKTSYAILQNDDRLLNIGIIAVTKLGELNELKASASIRYLFSTVENEDFQIACLKSLSKLVQKDSAFTDYLNSLYDSGLSDLLSGKASNVNLLRVYAEALGNFADPSSFDVLIKTLFYPVNDGLKDTVKTALNNISFNYFDEILAKTMQKNIQYIWTLYLLAKENKRIEGPELGRISELVIDYGLKNLKGADLESSENLIEETLPVLSALKWSKASSQVNKFFYYAQGLRKTSPRGDELLIKIIDCMGNLGTIECSQNLSIFLGVLNSETEKTKQYSEPLVLSVITALRKLGDKTAFDYLLYVEYLNYSETVKQASRNAIEELKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N38</accession>
    <name>Q73N38_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PilZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971924.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678853.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1318"/>
    <dbReference type="EnsemblBacteria" id="AAS11835">
        <property type="protein sequence ID" value="AAS11835"/>
        <property type="gene ID" value="TDE_1318"/>
    </dbReference>
    <dbReference type="GeneID" id="2739576"/>
    <dbReference type="KEGG" id="tde:TDE_1318"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1267"/>
    <dbReference type="eggNOG" id="COG5581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_749921_0_0_12"/>
    <dbReference type="OMA" id="FWRKDDA"/>
    <dbReference type="OrthoDB" id="1203468at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="217"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="384" mass="44760" checksum="545B114216A32E5A" modified="2004-07-05" version="1">MYILVVFFIVFLLFTAFSFTLPGRRFLDLIRFFTEGKDRGFLFSNLLLLWRTANYVGLEDKTRLFWSVAALDECIRFIARQVENKLDADVSQKMQILLNKLYDYRTKIELEEVQKKRRIESTHEIYIGQICIIFVPRETTVYGKLMANTKNELVFALFDASAERAEKVNWQNKAVRVYFWKQNDAGYVFSSEAVKAKKIEDRIEIYIKHSKKIVRTQKRKSVRASCDIEGLMFPLRAGDPYNSDYEIQGGVKSNIKDISEDGAMFFVKGKAAKGIRMKLQFKLKNTEIVMCGKIVRFVYDQPLNKSRVHFQCEFLDQKMKNVILSYIYNIATTDDNTEFINNILKEENNDHSVADQKIKDNDFLQDGLTDGQMLYDFAESKGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N41</accession>
    <name>Q73N41_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971921.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1315"/>
    <dbReference type="DNASU" id="2739573"/>
    <dbReference type="EnsemblBacteria" id="AAS11832">
        <property type="protein sequence ID" value="AAS11832"/>
        <property type="gene ID" value="TDE_1315"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1315"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1264"/>
    <dbReference type="eggNOG" id="COG2604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026503_0_0_12"/>
    <dbReference type="OMA" id="PQYWNTR"/>
    <dbReference type="OrthoDB" id="912403at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAF_flag10" evidence="1">
        <location>
            <begin position="229"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="578" mass="65813" checksum="AE8461AE69F712DC" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N76</accession>
    <name>Q73N76_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">purL</name>
        <name evidence="9" type="ordered locus">TDE_1279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971886.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1279"/>
    <dbReference type="EnsemblBacteria" id="AAS11797">
        <property type="protein sequence ID" value="AAS11797"/>
        <property type="gene ID" value="TDE_1279"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1279"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1229"/>
    <dbReference type="eggNOG" id="COG0046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003100_0_0_12"/>
    <dbReference type="OMA" id="FIEPYQG"/>
    <dbReference type="OrthoDB" id="26038at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="8">
        <location>
            <begin position="8"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="108"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="241"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="484"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="623"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
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                <person name="Shvartsbeyn A."/>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971845.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668509.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1238"/>
    <dbReference type="EnsemblBacteria" id="AAS11756">
        <property type="protein sequence ID" value="AAS11756"/>
        <property type="gene ID" value="TDE_1238"/>
    </dbReference>
    <dbReference type="GeneID" id="2741180"/>
    <dbReference type="KEGG" id="tde:TDE_1238"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1191"/>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094156_0_0_12"/>
    <dbReference type="OMA" id="STFWNDD"/>
    <dbReference type="OrthoDB" id="1996603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="116" mass="12275" checksum="C948068DAAEF4123" modified="2004-07-05" version="1">MGGLGIALLVLFVIICAIIIFLVLLQNEEGDSLGGLFSGGSNSAFGSKSSNVLTRATYVVVALFFVTTFLLALITKTPSDSGLSEEAMKKQTETSTDWWKSDDGTDSGTETKKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ND0</accession>
    <name>Q73ND0_TREDE</name>
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        <submittedName>
            <fullName evidence="5">Zinc ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">troB</name>
        <name evidence="5" type="ordered locus">TDE_1225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971832.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678718.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1225"/>
    <dbReference type="EnsemblBacteria" id="AAS11743">
        <property type="protein sequence ID" value="AAS11743"/>
        <property type="gene ID" value="TDE_1225"/>
    </dbReference>
    <dbReference type="GeneID" id="2741167"/>
    <dbReference type="KEGG" id="tde:TDE_1225"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1180"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_12"/>
    <dbReference type="OMA" id="SVWDVVM"/>
    <dbReference type="OrthoDB" id="1721927at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="255" mass="28572" checksum="55364DA2700A88D9" modified="2004-07-05" version="1">MNTGAEHLKENLIPAFCVEDLTLAYREKPVLWDIDVCVPQGAMEAVVGPNGAGKSTLLKAMMGILPIASGEIKIFGKSYKSQRKRIAYVPQRSSVDWDFPTTVFDVVLMGSYGNLGWIKRPGQKEKKEAMSALEKVGMLEFAKRQISELSGGQQQRVFLARALVQNADLYFMDEPFQGVDAATEQAIVKLLKELKENGKTLLVVHHDLQTVKDYFDRVLLLNVRLIAEGSIEEVFTEENLRKTYGGRIAYNSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NN1</accession>
    <name>Q73NN1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971729.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670683.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1121"/>
    <dbReference type="EnsemblBacteria" id="AAS11610">
        <property type="protein sequence ID" value="AAS11610"/>
        <property type="gene ID" value="TDE_1121"/>
    </dbReference>
    <dbReference type="GeneID" id="2739537"/>
    <dbReference type="KEGG" id="tde:TDE_1121"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1081"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1453807_0_0_12"/>
    <dbReference type="OMA" id="FAALEYW"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="40"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="180" mass="20856" checksum="7D5B7C3AA98DB12F" modified="2004-07-05" version="1">MTAIKELKVDEKSPLFDKTGMLYKEFPSDFRQIRYFTLLIVQSAPLEIKGINLLEQQISEIIKNAVKHGNRCNPSKKVKVWYEFSSTHAHLIVEDEGEGFKEIDKWNEFNRKRLECLHKQDFANLGAYVSFRTARSDEYDGGNALFAALEYWDGGFIFNKKKNGVAMLKKYPQKKHGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NT5</accession>
    <name>Q73NT5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1067</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971675.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682378.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1067"/>
    <dbReference type="EnsemblBacteria" id="AAS11556">
        <property type="protein sequence ID" value="AAS11556"/>
        <property type="gene ID" value="TDE_1067"/>
    </dbReference>
    <dbReference type="GeneID" id="2740828"/>
    <dbReference type="KEGG" id="tde:TDE_1067"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1027"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_12"/>
    <dbReference type="OMA" id="CHFPEDP"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="70"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="105"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="385" mass="43585" checksum="A15AE5AC2DE74B39" modified="2004-07-05" version="1">MSKILLETRGLKQYFPTGKTRNERKTLKRIADEALKVCAGMFNTKVGMSQLMDMYKSGKDLGKELTDLILDYETYSDLHGQNLCVIANDGIDLVIHEGETVGLVGESGCGKSTLGRTILKLYKPTAGEIFFEGENITNYTVTQMMPLRKKMQIIFQDPYSSLNPKMTVGQIIGEALLEHGMFKKKDPAYEKYVKEIMNTCGLADYMIYRYPHEFSGGQRQRIGIARALALKPKFIVCDEAVSALDVSIQSQIINLLNDLQKEFNLSYLFISHDLSVVKHISDRIGVMYLGNMVEFTDKREMYANPLHPYTKVLLSAIPETDLQKMRTKRRILLEGDIPSNIITPTGCKFHTRCPIAKDICKREIPQFKEEKPGHFVACHFSGAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NY5</accession>
    <name>Q73NY5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971624.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1015"/>
    <dbReference type="EnsemblBacteria" id="AAS11505">
        <property type="protein sequence ID" value="AAS11505"/>
        <property type="gene ID" value="TDE_1015"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1015"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.975"/>
    <dbReference type="HOGENOM" id="CLU_3012956_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="67" mass="7518" checksum="393E06F6A55B5019" modified="2004-07-05" version="1">MGINEKIRPWPMIERIKTIKDAMGKSGIASAVLRAFENGRIKGKINKIKTSISLTKKSDIESSQVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P53</accession>
    <name>Q73P53_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971556.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670347.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0946"/>
    <dbReference type="EnsemblBacteria" id="AAS11437">
        <property type="protein sequence ID" value="AAS11437"/>
        <property type="gene ID" value="TDE_0946"/>
    </dbReference>
    <dbReference type="GeneID" id="2740979"/>
    <dbReference type="KEGG" id="tde:TDE_0946"/>
    <dbReference type="HOGENOM" id="CLU_1767236_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="147" mass="16363" checksum="11BD0D705B09C83C" modified="2004-07-05" version="1">MASAWLAGLEFTHFAGEVLKIGRPCPILSFEFCLSAKHRKNVTTAVRGGKAVKPNRQNVFCGAERIVIEFYAGNAAGRMSMALNSIKFFKSTTSRQSIGVVDLIVLPLPIHYHVNRFLLFAFGMQQVKMPHLNKKNTPSFLIGCFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P77</accession>
    <name>Q73P77_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971532.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682222.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0922"/>
    <dbReference type="EnsemblBacteria" id="AAS11413">
        <property type="protein sequence ID" value="AAS11413"/>
        <property type="gene ID" value="TDE_0922"/>
    </dbReference>
    <dbReference type="GeneID" id="2740387"/>
    <dbReference type="KEGG" id="tde:TDE_0922"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.890"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OMA" id="HRISSIM"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="337"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="597" mass="67157" checksum="8399A3011876FF89" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PA7</accession>
    <name>Q73PA7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971502.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682172.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0892"/>
    <dbReference type="EnsemblBacteria" id="AAS11383">
        <property type="protein sequence ID" value="AAS11383"/>
        <property type="gene ID" value="TDE_0892"/>
    </dbReference>
    <dbReference type="GeneID" id="2739766"/>
    <dbReference type="KEGG" id="tde:TDE_0892"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.862"/>
    <dbReference type="eggNOG" id="COG3694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071040_0_1_12"/>
    <dbReference type="OMA" id="WDFNERY"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="262" mass="30609" checksum="FF70BC14FDEB2392" modified="2004-07-05" version="1">MKKYLLILKAYFKGSLMNLMEYKFNFISGGTFELVWLFMYLIFIDTIFIHTETVNGWDKYRMLMLTFQGGLMDSVFTFLIVPGLKRLPEMINAGTLDFILLKPLNQRFTISFNEFDIPQIKNIIINITGLTYCFIKLNIRMTPLKLLLYILLSLNGFFLIYSIMFILMSLAFWFMRMDIVMGIGSELITIGNKPMQIYPRLLQKILIFVIPLFVCFIFPILFAVKDLSVSYILYSFAASFIFFLLSNFIFKKGVRRYVGSGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PH4</accession>
    <name>MURE_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
            <ecNumber evidence="1">6.3.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murE</name>
        <name type="ordered locus">TDE_0825</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.-" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971435.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PH4"/>
    <dbReference type="SMR" id="Q73PH4"/>
    <dbReference type="STRING" id="243275.TDE_0825"/>
    <dbReference type="PRIDE" id="Q73PH4"/>
    <dbReference type="EnsemblBacteria" id="AAS11316">
        <property type="protein sequence ID" value="AAS11316"/>
        <property type="gene ID" value="TDE_0825"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0825"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.795"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022291_4_1_12"/>
    <dbReference type="OMA" id="CFMEVSS"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
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    </dbReference>
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    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
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    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000325326" description="UDP-N-acetylmuramyl-tripeptide synthetase">
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            <begin position="1"/>
            <end position="532"/>
        </location>
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        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="127"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
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        <location>
            <position position="240"/>
        </location>
    </feature>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <sequence length="532" mass="58878" checksum="3CFC23707CAD863E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
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    <organism evidence="10 11">
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        <lineage>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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            <end position="72"/>
        </location>
    </feature>
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    </feature>
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    </feature>
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</entry>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Tettelin H."/>
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                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
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                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
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                <person name="Amin A."/>
                <person name="Vashisth P."/>
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                <person name="Xiang Q."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
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        <location>
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        <location>
            <begin position="355"/>
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        <ligand>
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        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS11303.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
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    </evidence>
    <sequence length="537" mass="61107" checksum="6B1C496D56C31C90" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PJ5</accession>
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        <name evidence="4" type="ordered locus">TDE_0804</name>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
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                <person name="Howell J.K."/>
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                <person name="Amin A."/>
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                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Tettelin H."/>
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                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
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                <person name="Selengut J."/>
                <person name="Ren Q."/>
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                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
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                <person name="Tsegaye G."/>
                <person name="Malek J."/>
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                <person name="Shatsman S."/>
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                <person name="Amin A."/>
                <person name="Vashisth P."/>
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                <person name="Sodergren E."/>
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                <person name="Weinstock G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
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                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
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                <person name="Ren Q."/>
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                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971351.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0740"/>
    <dbReference type="EnsemblBacteria" id="AAS11232">
        <property type="protein sequence ID" value="AAS11232"/>
        <property type="gene ID" value="TDE_0740"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0740"/>
    <dbReference type="HOGENOM" id="CLU_3206546_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="45" mass="5005" checksum="E35B5E4AD1BC4DD4" modified="2004-07-05" version="1">MKAVQDTRCRKRCKSGDVSAGVSLPKLVLKIVHGYTIFKHSPYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q04</accession>
    <name>Q73Q04_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_0640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971254.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681835.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0640"/>
    <dbReference type="EnsemblBacteria" id="AAS11135">
        <property type="protein sequence ID" value="AAS11135"/>
        <property type="gene ID" value="TDE_0640"/>
    </dbReference>
    <dbReference type="GeneID" id="2739365"/>
    <dbReference type="KEGG" id="tde:TDE_0640"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.618"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_12"/>
    <dbReference type="OMA" id="RDQTYMM"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="357"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="458"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="744" mass="81700" checksum="1F594359EB9CF616" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q94</accession>
    <name>Q73Q94_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TfoX N-terminal domain family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971163.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681704.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0549"/>
    <dbReference type="EnsemblBacteria" id="AAS11044">
        <property type="protein sequence ID" value="AAS11044"/>
        <property type="gene ID" value="TDE_0549"/>
    </dbReference>
    <dbReference type="GeneID" id="2740537"/>
    <dbReference type="KEGG" id="tde:TDE_0549"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.534"/>
    <dbReference type="eggNOG" id="COG3070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151771_1_0_12"/>
    <dbReference type="OMA" id="EYILYYR"/>
    <dbReference type="OrthoDB" id="2040341at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007076">
        <property type="entry name" value="TfoX_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04993">
        <property type="entry name" value="TfoX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfoX_N" evidence="1">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="106" mass="12175" checksum="73A6FB6E7564CA01" modified="2004-07-05" version="1">MASSKEYLNFILNQLSELEDISYRAMMGEYILYYKGKIVGGIYDDRLLVKSVKSAIAYMPNAGYELPYDGAKEMLLVDDVDSKDFLTGLFKTMFDELPAPKPKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QC0</accession>
    <name>Q73QC0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971137.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0523"/>
    <dbReference type="EnsemblBacteria" id="AAS11018">
        <property type="protein sequence ID" value="AAS11018"/>
        <property type="gene ID" value="TDE_0523"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0523"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.509"/>
    <dbReference type="eggNOG" id="ENOG502Z7NH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091303_0_0_12"/>
    <dbReference type="OMA" id="GNVAVFW"/>
    <dbReference type="OrthoDB" id="1060869at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025335">
        <property type="entry name" value="DUF4241"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14025">
        <property type="entry name" value="DUF4241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="197" mass="22511" checksum="E528F50A6BDA8082" modified="2004-07-05" version="1">MPMGTVHFPTGNILVRDPLVYLNKSEEPYLQKVPTGIFPLETLVAEIEEDHYRYVATRVRFSDEKAAVYREALIGNEDLDDVDEESFFGFNVDAGLATVVDVKARDAYCDFESRWVNENPGKNIYDDYFAKEFEKSYAANPRFQRDGGDWINYPLEGTDLTVPMIQSGFGDGKYPVYFGYDKNDAICELVIEYIFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QC3</accession>
    <name>Q73QC3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971134.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681651.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0520"/>
    <dbReference type="EnsemblBacteria" id="AAS11015">
        <property type="protein sequence ID" value="AAS11015"/>
        <property type="gene ID" value="TDE_0520"/>
    </dbReference>
    <dbReference type="GeneID" id="2739257"/>
    <dbReference type="KEGG" id="tde:TDE_0520"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.506"/>
    <dbReference type="eggNOG" id="COG4282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113681_0_0_12"/>
    <dbReference type="OrthoDB" id="1776264at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="40"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="195" mass="22967" checksum="EF5A0A66691270DF" modified="2004-07-05" version="1">MQLIDKIKQIEKYICEHFEEWDLDDPVEEEYLDDYQEISGASEEEISAFEEKLGITLPEDFKELYRYKNGSKYLSILPCVIDEIEMPFNLMSLQTVTNTKEHFQNRDALLTEFTDYFTNEDIENMKDSRIKPYLFNKKWIPFAEYCDSCFLMLDFDPDTAGKEGQIICYIHDPDKVVYAAPSITELIDDIIAEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QI9</accession>
    <name>Q73QI9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP_bind_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971068.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0454"/>
    <dbReference type="EnsemblBacteria" id="AAS10949">
        <property type="protein sequence ID" value="AAS10949"/>
        <property type="gene ID" value="TDE_0454"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0454"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.441"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_5_2_12"/>
    <dbReference type="OMA" id="IGDEACP"/>
    <dbReference type="OrthoDB" id="1051352at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="67"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="276" mass="31571" checksum="A4F64064ADE292BC" modified="2004-07-05" version="1">MFSKFFISALKFIQHLYSLSAGSLLKQKPLSFFKKNIILISMANPKLFRTIDRAVFDYKMIEEGDRILLAASGGKDSTALAEYFSMRLKRPSPRFEVHAMHIATDVAPPLSPDLIKMFENWNIPLTIKTVSVLGRLKPNEKMNCWWCSTQRRTELNKFAMEEGFNKIALGHHLDDILETLLMNSLEKGILSTMPPVLKFEKYPVTMIRPLCLADLPMIIRHSEQAGYICSTCTCNFQENSARKTARSRLDRLTGGSYKLKINLFNSLKNILPEYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QN4</accession>
    <name>Q73QN4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971023.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672736.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0409"/>
    <dbReference type="EnsemblBacteria" id="AAS10904">
        <property type="protein sequence ID" value="AAS10904"/>
        <property type="gene ID" value="TDE_0409"/>
    </dbReference>
    <dbReference type="GeneID" id="2740155"/>
    <dbReference type="KEGG" id="tde:TDE_0409"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.396"/>
    <dbReference type="eggNOG" id="COG3807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137994_1_0_12"/>
    <dbReference type="OMA" id="ASYKGSH"/>
    <dbReference type="OrthoDB" id="2036545at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="158" mass="17488" checksum="45F14ABEE28E24B8" modified="2004-07-05" version="1">MKKSKILCLLMFFVVLGILTAEKSSKKMYVNIKETWIKSDSGFFAKDLVRVRYGDQVYLLEEKGKWMKVSPVSNPNIVGWLPKANLTKKKIVGSFDKKTSAEAKELSLAGKGLTEGSGSEFSSSGKKNYAAVDSVEGIKINPSDLHFFIKEGLLEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QN6</accession>
    <name>Q73QN6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase (NADPH), homotetrameric</fullName>
            <ecNumber evidence="2">1.4.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gltA</name>
        <name evidence="2" type="ordered locus">TDE_0407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.4.1.13" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971021.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681438.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0407"/>
    <dbReference type="EnsemblBacteria" id="AAS10902">
        <property type="protein sequence ID" value="AAS10902"/>
        <property type="gene ID" value="TDE_0407"/>
    </dbReference>
    <dbReference type="GeneID" id="2740153"/>
    <dbReference type="KEGG" id="tde:TDE_0407"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.394"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_3_12"/>
    <dbReference type="OMA" id="QETQCEQ"/>
    <dbReference type="OrthoDB" id="671513at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006004">
        <property type="entry name" value="Glut_synth_NADPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01316">
        <property type="entry name" value="gltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="503" mass="55095" checksum="338B8B0A00B7D194" modified="2004-07-05" version="1">MENINKECHKHVTHEDLSDRAKQLWADLKGKTLTPKERAQIPIQEMPTLDPHKRASLMNEVAMGYTDEQARIEAERCLNCKNKPCVKGCPVGIPIPEFIAEIQKGDYKKAVDIIKTTNLLPAICGRVCPQEKQCQAFCTVGKMLKSTEQAVAIGRLERFVADWERNNNKITIPPVAPETGKKVAIIGSGPAGLTVAADVRREGHSVTVFEAFHKTGGVMVYGIPEFRLPKEIVAKEVENLEKMGVEFKTNFLVGRTETLEQLLKEDGYDAAFIGTGAGLPKFMGIEGENLIGVFSANEYLTRANLMKAYDAEHSDTPLYEAETLAVIGGGNVAMDAARMGYRLGCKKVYCIYRRTRAEMPARIEEVAHAEEEGVEFCFLQNPTRIIGDKEGKVCAIEVLDYELGEPDESGRRKPVAKPGTEHQIKVDAVIVALGNDSNPLMAQTSHGLEVTKKGNIVVDENQKTSIEGVWAGGDIVLGAATVILAMGEGRKAAAAINEYLKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QP3</accession>
    <name>Q73QP3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971014.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681428.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0400"/>
    <dbReference type="EnsemblBacteria" id="AAS10895">
        <property type="protein sequence ID" value="AAS10895"/>
        <property type="gene ID" value="TDE_0400"/>
    </dbReference>
    <dbReference type="GeneID" id="2739409"/>
    <dbReference type="KEGG" id="tde:TDE_0400"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.389"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_12"/>
    <dbReference type="OMA" id="FLRTYMY"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="306" mass="35040" checksum="39A8B1C9621DC970" modified="2004-07-05" version="1">MEFKQLEIFIKLVENLSFSTTASELNISQPTVSLTLKQLEEELDTPLFLRSTRELKLTEAGNKLYNEAKNILAERDKLIEKFIHPERKVITIGASTIPAGYLLPSIVREFKKKHPDIYIKVEEKNSLETIKKVSLNTVDIGIVGMKIEDENCEFLPIYKDEFVFISANNSYYQKLKKSNPNLKRIAEEPFIIREAGSAVKQNMELILKSQKIDLDSINISASINDTEVIKQLTAEGLGTSFISRIAVEDMVKNKKLIAFELGDVPHQYRNIYLVWNKKINYASHIKDFLNCTECFKVKTAIEEKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QR8</accession>
    <name>Q73QR8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_0375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970989.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681393.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0375"/>
    <dbReference type="EnsemblBacteria" id="AAS10870">
        <property type="protein sequence ID" value="AAS10870"/>
        <property type="gene ID" value="TDE_0375"/>
    </dbReference>
    <dbReference type="GeneID" id="2739468"/>
    <dbReference type="KEGG" id="tde:TDE_0375"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.365"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_12"/>
    <dbReference type="OMA" id="INNGEIW"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015408">
        <property type="term" value="F:ABC-type ferric iron transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03259">
        <property type="entry name" value="ABC_Carb_Solutes_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015853">
        <property type="entry name" value="ABC_transpr_FbpC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS10870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="316" mass="35934" checksum="AEBAB501721E8228" modified="2004-07-05" version="1">MYLELTNLTKTYKEKNAVKNISFNLEKGKLLCLLGPSGCGKSTVLKSIGGFLKPDSGKIILDGKEITNDPPENRNVSTVFQSYGLFPHMNVLSNIIYGLKFKKMPKAERVEAGMKMIKTMGLSGYEKKHISELSGGEQQRVALARSLIIRPKLLLLDEPLSNLDAKLRINMRKEIKQIQKEFNITTIFVTHDQSEAFEIADKIILMNNGEIIQEGTAESLYNQPASEFALDFIGTNNKIENSYIRPEKIKVFKSLPEENMGNFEEAQIINIIFKGEIIELFLKTKEKELKAIVLNNDCNYQKNERVYITYIKENLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QV7</accession>
    <name>Q73QV7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970950.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681303.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0336"/>
    <dbReference type="EnsemblBacteria" id="AAS10831">
        <property type="protein sequence ID" value="AAS10831"/>
        <property type="gene ID" value="TDE_0336"/>
    </dbReference>
    <dbReference type="GeneID" id="2739335"/>
    <dbReference type="KEGG" id="tde:TDE_0336"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.325"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041771_2_3_12"/>
    <dbReference type="OMA" id="EIAYVYQ"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS10831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="372" mass="41825" checksum="830B4365776EFF48" modified="2004-07-05" version="1">MYQENKHRLQTISFFVLLAGMLILVGKLFLPYASVLLWSAVIYVLVRPLYNKILSRMNKEKKTFPIKKRLLAGSFAIITVLVVAGVLFFVVIKIFGQGKILVQNIQSFLENINNSESGFSKTDIAAIVNRLSMGTVDISNLDLQKEFLNLLSSSSDKILRYATSLVKNAGSFFLSLVFFAFALYFFYVDGAYLFSLLKHAIPIDNETSDKLFSKIGEITTNLFKGLFLVSFYQCLASFIVYLIFGVQSALLLAILTFFSTFLPIVGCGLIWFPVGVGLCFTDGLVKGLIFLVVAGSIISFMDNFLRPFFLKDRIKIHPLLIFFSMLGGVSMFSFDGIILGPMIVILFFTILDMALDIEEKKENDEDNFEHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QZ5</accession>
    <name>Q73QZ5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2075 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970912.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681239.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0298"/>
    <dbReference type="EnsemblBacteria" id="AAS10793">
        <property type="protein sequence ID" value="AAS10793"/>
        <property type="gene ID" value="TDE_0298"/>
    </dbReference>
    <dbReference type="GeneID" id="2740285"/>
    <dbReference type="KEGG" id="tde:TDE_0298"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.286"/>
    <dbReference type="eggNOG" id="COG3410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031446_0_0_12"/>
    <dbReference type="OMA" id="LDLKNFH"/>
    <dbReference type="OrthoDB" id="512912at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018647">
        <property type="entry name" value="SLFN_3-like_DNA/RNA_helicase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09848">
        <property type="entry name" value="DUF2075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2075" evidence="1">
        <location>
            <begin position="234"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="652" mass="75626" checksum="AD88F7B98A46F00B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QZ7</accession>
    <name>Q73QZ7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate formimidoyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_0296</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-histidine degradation into L-glutamate; L-glutamate from N-formimidoyl-L-glutamate (transferase route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.5" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970910.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681237.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0296"/>
    <dbReference type="EnsemblBacteria" id="AAS10791">
        <property type="protein sequence ID" value="AAS10791"/>
        <property type="gene ID" value="TDE_0296"/>
    </dbReference>
    <dbReference type="GeneID" id="2740283"/>
    <dbReference type="KEGG" id="tde:TDE_0296"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.285"/>
    <dbReference type="eggNOG" id="COG3643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040037_0_0_12"/>
    <dbReference type="OMA" id="DEDHNRL"/>
    <dbReference type="OrthoDB" id="780971at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00555"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030409">
        <property type="term" value="F:glutamate formimidoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013802">
        <property type="entry name" value="Formiminotransferase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037070">
        <property type="entry name" value="Formiminotransferase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004227">
        <property type="entry name" value="Formiminotransferase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012886">
        <property type="entry name" value="Formiminotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02971">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07837">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01221">
        <property type="entry name" value="FTCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01222">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="SSF55116"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02024">
        <property type="entry name" value="FtcD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0290">Folate-binding</keyword>
    <keyword evidence="5" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FTCD_N" evidence="8">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="FTCD" evidence="7">
        <location>
            <begin position="182"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="299" mass="33342" checksum="FC62D20F3AFDC3AE" modified="2004-07-05" version="1">MMNKIIECVPNFSNGRDPEVLEKIIAPFRGKENVKLLDYESDKDHNRSVVTVIGEPEELKKTVVEAIGIAASLIDLRKHEGAHPRMGATDVVPFIPIKNSTMEECIELSKEVGKLIWEQHKIPVFLYEKSASSPARENLSNIRKGQFEGMAEKVKQPEWKPDFGGTEIHPSAGVTAVGCRMPLVAFNVNLATNDLSIADKIAKKVRFIGGGLRFVKAMGVDLTERGIVQVSMNMTDYTKTSLYQSYEMVKMEAKRYGVNVVGTEIVGLTPMAALMDVASYYLQIENFEFSQIIEARLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QZ9</accession>
    <name>Q73QZ9_TREDE</name>
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        <submittedName>
            <fullName evidence="3">TrkA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970908.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681234.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0294"/>
    <dbReference type="EnsemblBacteria" id="AAS10789">
        <property type="protein sequence ID" value="AAS10789"/>
        <property type="gene ID" value="TDE_0294"/>
    </dbReference>
    <dbReference type="GeneID" id="2741385"/>
    <dbReference type="KEGG" id="tde:TDE_0294"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.283"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_3_3_12"/>
    <dbReference type="OMA" id="AIGANIQ"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:potassium ion transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="134"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="245" mass="27291" checksum="B1C1D21DE3B6F36B" modified="2004-07-05" version="1">MKKFAIMGLGTFGVRMLDELIKIGAEVIIIEQNKDLIEMYKSKASSAIVLEEISELSVRKILPSKVDTVIVDFGRKVELSVISTTILKNLGIANIVVRAQSDEHGRLLKTVGATRIIYPDSEAAKRTTPILAADLLLKFMPISKNLALAEVGVEARYVGKSLAESNIRKDMGVNIIARRKKESEDFIFMDDPEYKFEEDDVLLVVASEEHIYNFSGGKISLKNNLKKDGEIKPSIFKNLFSSKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R20</accession>
    <name>Q73R20_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970887.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681209.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0273"/>
    <dbReference type="EnsemblBacteria" id="AAS10768">
        <property type="protein sequence ID" value="AAS10768"/>
        <property type="gene ID" value="TDE_0273"/>
    </dbReference>
    <dbReference type="GeneID" id="2741566"/>
    <dbReference type="KEGG" id="tde:TDE_0273"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.264"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OMA" id="DINAIRM"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="338"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="373"/>
            <end position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="588" mass="64923" checksum="2DF06CA72D614075" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R45</accession>
    <name>Q73R45_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970862.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681165.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0246"/>
    <dbReference type="EnsemblBacteria" id="AAS10743">
        <property type="protein sequence ID" value="AAS10743"/>
        <property type="gene ID" value="TDE_0246"/>
    </dbReference>
    <dbReference type="GeneID" id="2741445"/>
    <dbReference type="KEGG" id="tde:TDE_0246"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.241"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_6_1_12"/>
    <dbReference type="OMA" id="MEHGFSG"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="189" mass="22003" checksum="20BC8159FB9DE0A1" modified="2004-07-05" version="1">MQVLKEEVKDRILTAAEKVFYEQDYRSAKLTDIAEQADIPVALIYTYFKNKEGLFDEVVAGVLDKIIKMMEDEEKMEAGSPYERFNRGGASQLPKLLKNRIKLIILIDKSSGTKHENAKDMWVKRLEQHIKDGLKRYSKTKHDPMLAHILANNYVEGLMEIARHYKNEKWAEDMLFVLNKCYFNGVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R60</accession>
    <name>Q73R60_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">dnaN</name>
        <name evidence="13" type="ordered locus">TDE_0231</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970847.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681136.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0231"/>
    <dbReference type="EnsemblBacteria" id="AAS10728">
        <property type="protein sequence ID" value="AAS10728"/>
        <property type="gene ID" value="TDE_0231"/>
    </dbReference>
    <dbReference type="GeneID" id="2739083"/>
    <dbReference type="KEGG" id="tde:TDE_0231"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.224"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038149_4_0_12"/>
    <dbReference type="OMA" id="YLIMPVR"/>
    <dbReference type="OrthoDB" id="1040142at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="130"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="246"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS10728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="367" mass="41760" checksum="B31A44132875074E" modified="2004-07-05" version="1">MKISFDRDTLLKEISIAQEIIATKTALTILSNVLLSVKDGSLTIKATDIKVSFETKIPVNIIEEGSTTVFCDKFAGILSSLPAGEVEIEQKDQKLTIKSVVKKAKFQLKTIPENDFPAFTEPTNVNFFNIPTKEFKEMIHQTIFSVSDDETRYFMNGVYIENKEDTLYFIATDGRRLAHIKKNFGIPIPEFKGVIVPPKILNIINKRASDEGNIEVGIGEKNIFFNFNSYKFSSVLIDGQFPNYERVIPENQNLSFEVSRTEFIEALKRVSLLVELKTRRIFLNILPGSLIISSQENEIGSAREEIPCKYDGQEVMLALNYVYIEDPLKTITSDRIKVEFTEAMKAITLKPEPEEDFFHIIMPMQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R62</accession>
    <name>Q73R62_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATPase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970845.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681134.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0229"/>
    <dbReference type="EnsemblBacteria" id="AAS10726">
        <property type="protein sequence ID" value="AAS10726"/>
        <property type="gene ID" value="TDE_0229"/>
    </dbReference>
    <dbReference type="GeneID" id="2739081"/>
    <dbReference type="KEGG" id="tde:TDE_0229"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.222"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029852_0_0_12"/>
    <dbReference type="OMA" id="KIQRIWF"/>
    <dbReference type="OrthoDB" id="358981at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="626" mass="73157" checksum="D58375864552A9A3" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R90</accession>
    <name>Q73R90_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FlgM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970817.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0201"/>
    <dbReference type="EnsemblBacteria" id="AAS10698">
        <property type="protein sequence ID" value="AAS10698"/>
        <property type="gene ID" value="TDE_0201"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0201"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.196"/>
    <dbReference type="eggNOG" id="ENOG502ZRHI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184596_0_0_12"/>
    <dbReference type="OMA" id="DPSYIND"/>
    <dbReference type="OrthoDB" id="1846356at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035890">
        <property type="entry name" value="Anti-sigma-28_factor_FlgM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031316">
        <property type="entry name" value="FlgM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04316">
        <property type="entry name" value="FlgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101498">
        <property type="entry name" value="SSF101498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FlgM" evidence="2">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="93" mass="10535" checksum="F812814DDE1691D6" modified="2004-07-05" version="1">MMIEKLGGIDPIKNLQNTQKPRRMEKVEVSDSVQVSPEAQKLSEIYFAMDAVKAAPDIRREKIEEVARKLQDPSYIDSILDQTADKILDSLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R91</accession>
    <name>Q73R91_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmI</name>
        <name evidence="8" type="ordered locus">TDE_0200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970816.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956696.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0200"/>
    <dbReference type="EnsemblBacteria" id="AAS10697">
        <property type="protein sequence ID" value="AAS10697"/>
        <property type="gene ID" value="TDE_0200"/>
    </dbReference>
    <dbReference type="GeneID" id="2739016"/>
    <dbReference type="KEGG" id="tde:TDE_0200"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.195"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_4_0_12"/>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="OrthoDB" id="1059309at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018063">
        <property type="entry name" value="SAM_MeTrfase_RsmI_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01296">
        <property type="entry name" value="RSMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS10697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="223" mass="24341" checksum="8F2E44FBC88BE690" modified="2004-07-05" version="1">MGILFVVATPIGNLKDISFRALETFQEADFIACEDTRHTLGLLTHYEISKPLISCRAVNEAAASEKIVKLLDEGKKIAYASDAGTPAISDPGSILVRTARKAGHTIIPIPGASAFGAIMSIAGTYDKTVVFEGFLSPKAGKRKRRLQELFDFGAGFVLYESPYRIVKLLADIAEIDSNRELIIGRELTKLHEEIIKGPASEVLQNFEKRPSIKGEFSVFVTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RA0</accession>
    <name>Q73RA0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970807.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681082.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0191"/>
    <dbReference type="EnsemblBacteria" id="AAS10688">
        <property type="protein sequence ID" value="AAS10688"/>
        <property type="gene ID" value="TDE_0191"/>
    </dbReference>
    <dbReference type="GeneID" id="2741610"/>
    <dbReference type="KEGG" id="tde:TDE_0191"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.187"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_34_4_12"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017255">
        <property type="entry name" value="AcTrfase_GNAT_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037663">
        <property type="entry name" value="Acetyltransf_GNAT_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="142" mass="16178" checksum="1180AAC4EDE86D01" modified="2004-07-05" version="1">MIIREVTIDDYKDIRNLNKNALGYDFPLEKTKTQLEKILTGKEAKIFGAFVDNKLIGYVHIADYECSFNDSLKNIMGIAVDPSYRKQGIGRDLLTKAETWARDTGAAGIRLVSSVGRTEAHKFYEAMGYTSKKEQKNFRKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RB2</accession>
    <name>Q73RB2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970795.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0179"/>
    <dbReference type="EnsemblBacteria" id="AAS10676">
        <property type="protein sequence ID" value="AAS10676"/>
        <property type="gene ID" value="TDE_0179"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0179"/>
    <dbReference type="HOGENOM" id="CLU_3359075_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="36" mass="4181" checksum="79B4713A0D900CC6" modified="2004-07-05" version="1">MREGMVYFITMIEKTSIAITSLLAKKVQKVFQKYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RC2</accession>
    <name>Q73RC2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970784.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681050.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0168"/>
    <dbReference type="EnsemblBacteria" id="AAS10665">
        <property type="protein sequence ID" value="AAS10665"/>
        <property type="gene ID" value="TDE_0168"/>
    </dbReference>
    <dbReference type="GeneID" id="2739520"/>
    <dbReference type="KEGG" id="tde:TDE_0168"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.165"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_10_0_12"/>
    <dbReference type="OMA" id="TQRGMGT"/>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="133" mass="15085" checksum="297D78460B7ABFEB" modified="2004-07-05" version="1">MKVIYDQNRPIYLQIVEKIKCKIVYGELKPGDKIPSMSDMSVEMDVNPNTIFRVYKQLEGEGITESKRGLGSFVVNEPDLVGKLTEEMADQIILPAIEGLRNLKFSDEQIIESIKAKLKINNPDAEHRGMLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RS9</accession>
    <name>Q73RS9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Snf2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970623.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0006"/>
    <dbReference type="EnsemblBacteria" id="AAS10504">
        <property type="protein sequence ID" value="AAS10504"/>
        <property type="gene ID" value="TDE_0006"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0006"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.7"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_21_8_12"/>
    <dbReference type="OMA" id="MPCKHIA"/>
    <dbReference type="OrthoDB" id="325071at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022138">
        <property type="entry name" value="Helicase_SWF/SNF-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12419">
        <property type="entry name" value="DUF3670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="109"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="745"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1194" mass="134081" checksum="7731AAADB0453948" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RT2</accession>
    <name>Q73RT2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970620.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680854.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0003"/>
    <dbReference type="EnsemblBacteria" id="AAS10501">
        <property type="protein sequence ID" value="AAS10501"/>
        <property type="gene ID" value="TDE_0003"/>
    </dbReference>
    <dbReference type="GeneID" id="2741617"/>
    <dbReference type="KEGG" id="tde:TDE_0003"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.4"/>
    <dbReference type="eggNOG" id="ENOG502Z9XC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101764_0_0_12"/>
    <dbReference type="OMA" id="AYTTISW"/>
    <dbReference type="OrthoDB" id="1522031at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032479">
        <property type="entry name" value="DUF5058"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16481">
        <property type="entry name" value="DUF5058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="239" mass="26291" checksum="197908CC90B80C3C" modified="2004-07-05" version="1">MFDVNSSVLFWFAGIVILFVLIQSVFFLIKALRRAKELNMSQKKIKQIISGAAIFTVAPAISIILGMISLSKFLGLPLPWLRLSVLGALTYELTAASTAASVLDIPLDEPIANATAYTTISWVMALGIISGIVVIALFLPKMQKNLIKMKSKDEKWSKLLIDALFMGMISAFLGMIFSEIRLGLKGWIPVFVMFFSAFLMLVCGLVVKKTRAKWLESYAMPISLLGGMAFSIPITMLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>F7IVL3</accession>
    <name>F7IVL3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligopeptide/dipeptide ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971677.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682380.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1069"/>
    <dbReference type="EnsemblBacteria" id="AAS11558">
        <property type="protein sequence ID" value="AAS11558"/>
        <property type="gene ID" value="TDE_1069"/>
    </dbReference>
    <dbReference type="GeneID" id="2740830"/>
    <dbReference type="KEGG" id="tde:TDE_1069"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1029"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_2_12"/>
    <dbReference type="OMA" id="TRPWLFW"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="96"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="338" mass="38385" checksum="A980EF46D3342F10" modified="2011-07-27" version="1">MAQEENKNFSEKDEVILSPAQQIRIKFRNNRLAMMGFYMFVTIVLLVVVTHFYTKFTGYDFAKTDPTIKNNPPSWIHPFGTDKYGRDTFMRVLEGGWISLQVGFLSTFMAVTIGLTMGSVAGFFGGRVDNIIMRLIEILSSFPFLAIAYTLSAIFRERPPEFRLYVIVIILGLLSWTGLARLIRGQILALREQEFIVATRALGIKRRNQIFRHLVPNVLATVVVSATLTFASSILSEAFLSFLNLSVTEPIPTWGALLSKASENSTSLRTFWWIWIFPGAMLFFFIMSINLIGEGLRDSIDPKAEYTTKAQRKEARARRKEEKRLAKQAKQTVKEAAV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-24" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>P61538</accession>
    <name>RUVB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvB</name>
        <name type="ordered locus">TDE_1914</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972517.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679608.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61538"/>
    <dbReference type="SMR" id="P61538"/>
    <dbReference type="STRING" id="243275.TDE_1914"/>
    <dbReference type="EnsemblBacteria" id="AAS12428">
        <property type="protein sequence ID" value="AAS12428"/>
        <property type="gene ID" value="TDE_1914"/>
    </dbReference>
    <dbReference type="GeneID" id="2740412"/>
    <dbReference type="KEGG" id="tde:TDE_1914"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1811"/>
    <dbReference type="eggNOG" id="COG2255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055599_1_0_12"/>
    <dbReference type="OMA" id="IHRMSRP"/>
    <dbReference type="OrthoDB" id="874197at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000165622" description="Holliday junction ATP-dependent DNA helicase RuvB">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="61"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="343" mass="37905" checksum="7DB75D4E3ABAE5A6" modified="2004-05-24" version="1">MSDDFEVVRPEEQAGDEKDRDLRPRSLVDFQGQTKAKENLSVFIKAARERGESLDHLFLIGPPGLGKTTLAQITANELGVDFKVTGAPALDKPKDLAGILTTLTERSVFFIDEIHRLKPAIEEMLYIAMEDYELDWIIGQGPGARTVRIPIPPFTLVGATTRAGMVSSPLISRFGIVQRFEFYSHEELASIISRSASILEIEIEKKAAIALARCSRGTPRVANRLLRRMRDFAQVAGKSSIDEMTVAAGLKQLNIDGLGLETYDRQILRSIIENYSGGPVGAETLAISIGESQDTLEDYYEPYLIQSGLLQRTPRGRMVTLKAYEHLGLNPPKLGDGQEGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73IZ7</accession>
    <name>Q73IZ7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973378.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2780"/>
    <dbReference type="EnsemblBacteria" id="AAS13297">
        <property type="protein sequence ID" value="AAS13297"/>
        <property type="gene ID" value="TDE_2780"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2780"/>
    <dbReference type="HOGENOM" id="CLU_3349900_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="37" mass="4302" checksum="0754C404EC0E024C" modified="2004-07-05" version="1">MSFCNYRCIIEGGGIENAKTLLENIYRNFMHGSCFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J05</accession>
    <name>Q73J05_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter, ATP-binding protein, truncation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973370.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673416.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13289">
        <property type="protein sequence ID" value="AAS13289"/>
        <property type="gene ID" value="TDE_2772"/>
    </dbReference>
    <dbReference type="GeneID" id="2740739"/>
    <dbReference type="KEGG" id="tde:TDE_2772"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2617"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_61_13_12"/>
    <dbReference type="OMA" id="IQEYGTH"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="52" mass="6190" checksum="F744282E39E9AA06" modified="2004-07-05" version="1">MIAHRLSTVRNTDKIVLVENGTIQEYGTHDELIELKGRYYEMFTKQVENYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J27</accession>
    <name>Q73J27_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973347.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667012.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2749"/>
    <dbReference type="EnsemblBacteria" id="AAS13266">
        <property type="protein sequence ID" value="AAS13266"/>
        <property type="gene ID" value="TDE_2749"/>
    </dbReference>
    <dbReference type="GeneID" id="2740716"/>
    <dbReference type="KEGG" id="tde:TDE_2749"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2595"/>
    <dbReference type="eggNOG" id="COG4226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134927_1_1_12"/>
    <dbReference type="OMA" id="PNTDEEC"/>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="116" mass="13232" checksum="0EA4FA1B69A163AF" modified="2004-07-05" version="1">MKDFLEYKDYLGSVHFNADDEIFYGKIECIDDLISFEGNTVNDLKTAFIEAVEDYIELCKEAGKPAEKSYKGSFNIRISPAIHKKAKRQAIMQGISLNQFIQQAVEQAVTYNARQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J70</accession>
    <name>Q73J70_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Eisen J.A."/>
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                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
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                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Davidsen T.M."/>
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                <person name="Fouts D.E."/>
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    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2595"/>
    <dbReference type="EnsemblBacteria" id="AAS13112">
        <property type="protein sequence ID" value="AAS13112"/>
        <property type="gene ID" value="TDE_2595"/>
    </dbReference>
    <dbReference type="GeneID" id="2741299"/>
    <dbReference type="KEGG" id="tde:TDE_2595"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2453"/>
    <dbReference type="eggNOG" id="ENOG502ZFEP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_780621_0_0_12"/>
    <dbReference type="OMA" id="IHFANWK"/>
    <dbReference type="OrthoDB" id="1155109at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="348" mass="39944" checksum="7C0DFD35A5162BF5" modified="2004-07-05" version="1">MKVKRYFTILLLGLTTFFLHAKSLPDYELLKDNLKLVVFRKTGNFCLYNLSIRGKGKYTPLYDDRSLGRTNKFYVYKDNKVYELKKRVGKPVTIEADGDSIKIVYDFDDSFYVTQKLSFTEQTYGTGGPLLKIETIVENTSGSTAEFALKALFDTKLGEDRKIPLYTDLRTGIFRETVLEPKFEKDSAIISANSDLACLFLLNHSEAKIPAQIYVANWERLQSIKWLPKAVQGRLFSTQYSHNDSALLFVWPNEVLENSDSLKVTMFIGCYDFLRKKNTSVKEDVSDKTNSPVPQDKAEPPKNEKDYQYIQALLDKILEVESNPDMASDEYIEDLIKQTDNAIQNIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JI2</accession>
    <name>Q73JI2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma-54-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973191.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680578.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2593"/>
    <dbReference type="EnsemblBacteria" id="AAS13110">
        <property type="protein sequence ID" value="AAS13110"/>
        <property type="gene ID" value="TDE_2593"/>
    </dbReference>
    <dbReference type="GeneID" id="2741297"/>
    <dbReference type="KEGG" id="tde:TDE_2593"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2451"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_12"/>
    <dbReference type="OMA" id="HEHEIAN"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="2">
        <location>
            <begin position="142"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="378" mass="43228" checksum="D1D4A813FF020817" modified="2004-07-05" version="1">MKDCVYSAYSKEDAKHFIKEVGSLWNVSLTFDSSKIVDILKEKHFDFVIIDAESGGLFLPDTLELIKNEFPHIHIFIIIHCKQNDLQYNLLNSHVSEVFEIPKDFKGIYDKIENFFPEELCKEKTPAYTKEDENIQIIKKEIIGISKEICELREFIYRAANSNLPVLLSGETGVGKGVTANLIHRLSQVKNKKFLPINVSCIPESLAESFLFGTEEGSFTGAVKKEGAFFEASGGTIFLDEMETLSPDIQAKLLHVLESGLIRPVGSTKSKQVEFRLIAAANEDLQKMIDEKKFRQDLYYRLHVLHHEIPPLRNRKEDIKYIAQAYLTKAEKTISDRAQAKLNFHNWPGNIRELYNCLDRACNLAGDGEKIENRHIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JK5</accession>
    <name>Q73JK5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973012.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680349.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2413"/>
    <dbReference type="EnsemblBacteria" id="AAS12931">
        <property type="protein sequence ID" value="AAS12931"/>
        <property type="gene ID" value="TDE_2413"/>
    </dbReference>
    <dbReference type="GeneID" id="2739838"/>
    <dbReference type="KEGG" id="tde:TDE_2413"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2279"/>
    <dbReference type="eggNOG" id="ENOG502ZBBM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1179499_0_0_12"/>
    <dbReference type="OrthoDB" id="1652838at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="221" mass="26482" checksum="75EB7FF0886AFB79" modified="2004-07-05" version="1">MHIIYETNGLGFLGWITDLPGAYIRGKTLEEARGKVNKEIALYNEWLNFEKAIDMQINEEIKKSDLHIEDADSDIIFDSELIDFDKQDDFLFWCDKVLLSGTKTEEIYKRMKNKSLIDITMKRKTFYGDVYCTINDQYRHIVNVQNYYLNQIGTEMDIGDEFRLNRMEFIEKLKEKYLKEGNKLYRNESEDWTVKKVIRRAIWHDRIHIRAIERMENRLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JK8</accession>
    <name>Q73JK8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973009.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957226.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2410"/>
    <dbReference type="EnsemblBacteria" id="AAS12928">
        <property type="protein sequence ID" value="AAS12928"/>
        <property type="gene ID" value="TDE_2410"/>
    </dbReference>
    <dbReference type="GeneID" id="2740712"/>
    <dbReference type="KEGG" id="tde:TDE_2410"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2276"/>
    <dbReference type="eggNOG" id="COG1168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_15_0_12"/>
    <dbReference type="OMA" id="NEVCDVN"/>
    <dbReference type="OrthoDB" id="1462898at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027619">
        <property type="entry name" value="C_S_lyase_PatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04350">
        <property type="entry name" value="C_S_lyase_PatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="40"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="404" mass="46583" checksum="05848E637DD2BF37" modified="2004-07-05" version="1">MSINKTRKYDFENTLPRKNIGSAKWELMYQWKPDVSDGIIPLSVADMEFKNPPEITEGLKEYLDRLILGYSTRYADYDNAVINWLKRKHDYSVSPEMIMQTPGIVNAFFAAVNAFTEKGDGVIVMRPVYYPFSMAIEMNERELVNCSLLCDKDNYYTIDYEKFERLAKQPKNKLLIFCSPHNPVGRVWKKEELKKLAEIALENNVIVFSDEIWNDLVMPGYKHTLMASISKEIAANTITATAPSKTFNVAGLATSNIIVENENLRTKYYNMLQKMRSSSVNALGFKACEIAYTQCDKWLEELLQVLDNNQKLVKNYFDSNFPMLKSRFIEGTYLQWIDFRALGMDNQTLENFMHNEAQFFTDEGYVFGSEGDGFERINVGCPTKILQQHLEMLGDALKKKLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JP9</accession>
    <name>Q73JP9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase, class V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973058.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680415.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2460"/>
    <dbReference type="EnsemblBacteria" id="AAS12977">
        <property type="protein sequence ID" value="AAS12977"/>
        <property type="gene ID" value="TDE_2460"/>
    </dbReference>
    <dbReference type="GeneID" id="2739645"/>
    <dbReference type="KEGG" id="tde:TDE_2460"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2327"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_4_12"/>
    <dbReference type="OMA" id="APHIINF"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010969">
        <property type="entry name" value="Cys_dSase-rel_unknwn_funct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01977">
        <property type="entry name" value="am_tr_V_EF2568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="5"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="388" mass="41863" checksum="CCA13944902B6FF2" modified="2004-07-05" version="1">MKKRIFLDNAAGAFPKTPGLDQALAMALNMGTGNINRSTYTETEEAGLAVIETRELLCKLFNFQPATHVIFTSGVTASLNYIIKGFLKSGDRVLTSSFEHNAVMRPLVQMEKIGVKIDRVPAILKNGGTFVDTSLIESMIRPETRLAVFSHASNVTGFIQPIEEIASILKKHNIPLVIDGAQSAGHIPVDLTQLNPAAFCFTGHKGLLGPQGTGGILFDKDFAKEVEPLITGGTGSASDSEETPSFMPDKFEAGTQNIIGIAGLHHSLKWLDAFGIQNIHKREQKLLKLFLDGIKGLPIKIAGGESAENRVGIVSIDFSEFMDNAEAGASLEEKYGILTRCGLHCSPSAHKSIGTFPQGTVRFSTGPFTIEEEIETAIRAIKELCPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JS9</accession>
    <name>Q73JS9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973079.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2481"/>
    <dbReference type="EnsemblBacteria" id="AAS12998">
        <property type="protein sequence ID" value="AAS12998"/>
        <property type="gene ID" value="TDE_2481"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2481"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2347"/>
    <dbReference type="HOGENOM" id="CLU_3278174_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="41" mass="4981" checksum="2830D988477A7119" modified="2004-07-05" version="1">MMNIGITKNFFSFLRNYLSFRIKFSPLAFLPIIYYPYNILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JV0</accession>
    <name>Q73JV0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2511</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973109.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680478.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2511"/>
    <dbReference type="EnsemblBacteria" id="AAS13028">
        <property type="protein sequence ID" value="AAS13028"/>
        <property type="gene ID" value="TDE_2511"/>
    </dbReference>
    <dbReference type="GeneID" id="2739023"/>
    <dbReference type="KEGG" id="tde:TDE_2511"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2377"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_12"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034775">
        <property type="term" value="P:glutathione transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014223">
        <property type="entry name" value="ABC_CydC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02868">
        <property type="entry name" value="CydC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="24"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="342"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="375"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS13028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="555" mass="61176" checksum="FFF3ED5E3A0D4540" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JV7</accession>
    <name>TSAD_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="1">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsaD</name>
        <name type="synonym">gcp</name>
        <name type="ordered locus">TDE_2504</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973102.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680472.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JV7"/>
    <dbReference type="SMR" id="Q73JV7"/>
    <dbReference type="STRING" id="243275.TDE_2504"/>
    <dbReference type="PRIDE" id="Q73JV7"/>
    <dbReference type="EnsemblBacteria" id="AAS13021">
        <property type="protein sequence ID" value="AAS13021"/>
        <property type="gene ID" value="TDE_2504"/>
    </dbReference>
    <dbReference type="GeneID" id="2741477"/>
    <dbReference type="KEGG" id="tde:TDE_2504"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2371"/>
    <dbReference type="eggNOG" id="COG0533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_0_2_12"/>
    <dbReference type="OMA" id="HLEGHIY"/>
    <dbReference type="OrthoDB" id="1257362at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000303601" description="tRNA N6-adenosine threonylcarbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <sequence length="338" mass="36564" checksum="B64CDF1BDDA2F5E4" modified="2004-07-05" version="1">MKILGIESSCDETAAAVVEDGNKILSNIVATQIPFHKMYNGVVPEIASRKHTEWILPVVKQALAEAGLSLKEIDGIAATGRPGLMGSLLVGLTFAKTLAWSSNKPFIAVNHMLGHLYASHLENDIPYPYLGLLVSGGHSIICKVNNFDDIEVLGTTIDDAPGEAFDKVAKFYNLGYPGGAVIDKLAKSGNPKAANFPMPIIHKEGHKYDVSYSGLKTAVINQIDQFWNKDFEKTPENIAAAFQTRAVKILLRPLLDASIDTGLKTIVAGGGVAANSLLREKLAEHKELKCIFPSLKFCTDNAAMIAGLGYHYLKRGDRTPFTVEASARVEGFSKKGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K38</accession>
    <name>Q73K38_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972983.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680314.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2384"/>
    <dbReference type="EnsemblBacteria" id="AAS12902">
        <property type="protein sequence ID" value="AAS12902"/>
        <property type="gene ID" value="TDE_2384"/>
    </dbReference>
    <dbReference type="GeneID" id="2740686"/>
    <dbReference type="KEGG" id="tde:TDE_2384"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2252"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_8_4_12"/>
    <dbReference type="OMA" id="PALNEMN"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="196" mass="22474" checksum="80DC145EC4312BB7" modified="2004-07-05" version="1">MKIVLIRHGITVTNKKRIFSFDDSLLAEEAYPMLDGLKPKLKDFSSFKVYSSPFKRALQTAEYLGLKNIQTDKRLQEYNFGIFKGLTFEEAQTKYPIEAKNWIENNDSSAPPEGETSFEHFKRTSDFLEEAALKDENIIIVTHYGTITMALAWALDNFSLRNKFAPKNSTISILEVFLSDNKNEITHKGIEVFNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K61</accession>
    <name>Q73K61_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">High-affinity branched chain amino acid ABC transporter, amino acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972960.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674234.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2361"/>
    <dbReference type="EnsemblBacteria" id="AAS12879">
        <property type="protein sequence ID" value="AAS12879"/>
        <property type="gene ID" value="TDE_2361"/>
    </dbReference>
    <dbReference type="GeneID" id="2739970"/>
    <dbReference type="KEGG" id="tde:TDE_2361"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2229"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_6_2_12"/>
    <dbReference type="OMA" id="MEFTGAR"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284900" evidence="4">
        <location>
            <begin position="28"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="5">
        <location>
            <begin position="37"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="385" mass="42461" checksum="BE369BE8FB97B64E" modified="2004-07-05" version="1">MKKIRIYILSLLSVILILNSCTGKDEAKTTEDKATKPIYFAWYGPLTGDAKQYGDTEKIAVELALKDINDAGNGVLGGRKIIVDFYDDKNDAKEAVNIANKIVAEKKYLAVVGGFGSTPSMAAAPIYEKAKIINYSPTSSHADFSSLGKFMFRNTPTQQIETTQYADYVYTKLGIKSVAILNVNDDWGNNIAKIFTNEFVKLGGKITDLQTYIPNQTSDFTPMISKAKTTNPEAFFPVAYYQDSANIVRQAKNLDFNVQMILSSSTLKQELIDLAGDIVEGAFIMNAYSPDINTPEFIRVIGEYTKRTGKQGDAFVMQTYDVVKQLATAVDMAGSDDPVVVRETLANMKGYNALSGPYNMNELGDAVRSLVPMFIKNGKFTRIDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K81</accession>
    <name>SYL_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="1">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuS</name>
        <name type="ordered locus">TDE_2339</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972938.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680258.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73K81"/>
    <dbReference type="SMR" id="Q73K81"/>
    <dbReference type="STRING" id="243275.TDE_2339"/>
    <dbReference type="EnsemblBacteria" id="AAS12857">
        <property type="protein sequence ID" value="AAS12857"/>
        <property type="gene ID" value="TDE_2339"/>
    </dbReference>
    <dbReference type="GeneID" id="2739434"/>
    <dbReference type="KEGG" id="tde:TDE_2339"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2207"/>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_12"/>
    <dbReference type="OMA" id="TFMVLAP"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000152108" description="Leucine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="629"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <sequence length="858" mass="98404" checksum="087F7974B04C5837" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K86</accession>
    <name>Q73K86_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972933.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680251.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2334"/>
    <dbReference type="EnsemblBacteria" id="AAS12852">
        <property type="protein sequence ID" value="AAS12852"/>
        <property type="gene ID" value="TDE_2334"/>
    </dbReference>
    <dbReference type="GeneID" id="2739429"/>
    <dbReference type="KEGG" id="tde:TDE_2334"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2203"/>
    <dbReference type="HOGENOM" id="CLU_952967_0_0_12"/>
    <dbReference type="OrthoDB" id="1639761at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="292" mass="34356" checksum="EE3ED0E559F8D4FE" modified="2004-07-05" version="1">MEKIKCPKCKSIMQEFDIKSKKVSKYEDCIRRCIQCQIGASNAQINPTFIYKDYRNNIPSNLLEHLNETLEKTLNTTNRENKKIKLGFSTSEDAVSWIFIKYFLVNDKLPVLQKILNLEDEISEILMWGVPQINRDLGCTENLKHICDSLGEDKKYYTEPDIIIITKSESVFVEVKVKSGNDKQAADNRNYDKYLLDKFYTDIEAAKKSSYYELIRNWTIGNIFAENNFKLINLAPQKLFSNENQDSDFKLFINSLKNSRNFIQLSWEAVFKNLKESDIEEYFYNELEKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KD2</accession>
    <name>Q73KD2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MazG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972886.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680184.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2286"/>
    <dbReference type="EnsemblBacteria" id="AAS12805">
        <property type="protein sequence ID" value="AAS12805"/>
        <property type="gene ID" value="TDE_2286"/>
    </dbReference>
    <dbReference type="GeneID" id="2740036"/>
    <dbReference type="KEGG" id="tde:TDE_2286"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2156"/>
    <dbReference type="eggNOG" id="COG3956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038356_0_1_12"/>
    <dbReference type="OMA" id="HPHIYGD"/>
    <dbReference type="OrthoDB" id="1099129at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="281" mass="32071" checksum="4F34AA1D7C5A5CD5" modified="2004-07-05" version="1">MENSQLIESFEALFNVIKRLRGPGGCPWDIAQTPMSMRKSLLEEAYEAADAIEEHHNTGQNAEHVKEELGDILLNVLMISYMYEQEGLFSTADIMKNLTEKLIRRHPHVFGETEGYEGPESDKKASTPESVLNQWENIKEKIERPKAESILDSIPKNFPPMLRALKISKKAAKAGFEWTEIGGLIEKMEEETAEFAEAVKSGSEAAMEDEIGDVFFVAVNAARFLKIDPEMALMHANKKFERRFRFVEAEMKKNGLELLPENGEKMEEFWNKAKLKERSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KF2</accession>
    <name>Q73KF2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reverse transcriptase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972866.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680154.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2266"/>
    <dbReference type="EnsemblBacteria" id="AAS12785">
        <property type="protein sequence ID" value="AAS12785"/>
        <property type="gene ID" value="TDE_2266"/>
    </dbReference>
    <dbReference type="GeneID" id="2740016"/>
    <dbReference type="KEGG" id="tde:TDE_2266"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2138"/>
    <dbReference type="eggNOG" id="COG3344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013584_0_0_12"/>
    <dbReference type="OMA" id="VRYMDDF"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="328" mass="38809" checksum="4A47B0F2EC620479" modified="2004-07-05" version="1">MKRKGNLYHKITEWNNLIAAFYNASRGKRLKPDVLLYEKNLYTNLKTLQNYLINQTVLLGSYRFFKIYDPKERIICAAPFNERVLHHAIINITESVFEKFQIYDSYACRKNKGTQAALLRALYFSRRFKYFLKLDMKKYFDSIPHSKLSLLLTCKFKDKALLHLFNKLIASYSVTEGWGVPIGNLTSQYFANFYLSFFDHYAKEKMNVRGYIRYMDDVLLFSDNLKDIKLIQKKAKNFLSCELDLTLKEEIIGMVKNGIPFLGFLVKPQGIYLSQKKKKRLKKKIKDYVHKFKIAYWTEEEFALHITPVFAHIAISRCRAYCNKYLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KH3</accession>
    <name>Q73KH3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972845.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667902.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2245"/>
    <dbReference type="EnsemblBacteria" id="AAS12764">
        <property type="protein sequence ID" value="AAS12764"/>
        <property type="gene ID" value="TDE_2245"/>
    </dbReference>
    <dbReference type="GeneID" id="2741350"/>
    <dbReference type="KEGG" id="tde:TDE_2245"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2119"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_1_1_12"/>
    <dbReference type="OMA" id="DWKEHIR"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
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        <property type="entry name" value="TopoIIA_CS"/>
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        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Toprim" evidence="6">
        <location>
            <begin position="399"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="605" mass="67955" checksum="6D6B5FC36D54F302" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KH6</accession>
    <name>Q73KH6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antigen, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972842.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680099.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73KH6"/>
    <dbReference type="STRING" id="243275.TDE_2242"/>
    <dbReference type="EnsemblBacteria" id="AAS12761">
        <property type="protein sequence ID" value="AAS12761"/>
        <property type="gene ID" value="TDE_2242"/>
    </dbReference>
    <dbReference type="GeneID" id="2741347"/>
    <dbReference type="KEGG" id="tde:TDE_2242"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2116"/>
    <dbReference type="eggNOG" id="ENOG5031BZG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007801_1_0_12"/>
    <dbReference type="OrthoDB" id="1009714at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="821" mass="90912" checksum="48AB335CEB8A295B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KN4</accession>
    <name>Q73KN4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CpXC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972784.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680030.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2183"/>
    <dbReference type="EnsemblBacteria" id="AAS12703">
        <property type="protein sequence ID" value="AAS12703"/>
        <property type="gene ID" value="TDE_2183"/>
    </dbReference>
    <dbReference type="GeneID" id="2740205"/>
    <dbReference type="KEGG" id="tde:TDE_2183"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2060"/>
    <dbReference type="eggNOG" id="ENOG5031C85">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1282737_0_0_12"/>
    <dbReference type="OMA" id="DANTEYI"/>
    <dbReference type="OrthoDB" id="1045248at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025682">
        <property type="entry name" value="CpXC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14353">
        <property type="entry name" value="CpXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CpXC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="218" mass="24954" checksum="BB1CB3CCD8F73D76" modified="2004-07-05" version="1">MKIHCPCDASFEIEHHAKINLDKEPEILKKIADGSYLTFKCPQCGRKVRSEIKTRIEWPSKKLILLFVPEADRIACLSSCTGLKEINEKTKKTEKIEYEKADETPVIGYSELAERLAVVEAGLDPHAMEVLKFFILDSGKDIKGKKIKIFFHSVNNDGSFEFYVYGLKEDQVAVMKIPVKLYDSICQDIKNKKKSEIFTAVYLGNYLSYQNIFTEGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KP7</accession>
    <name>Q73KP7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972771.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2170"/>
    <dbReference type="EnsemblBacteria" id="AAS12690">
        <property type="protein sequence ID" value="AAS12690"/>
        <property type="gene ID" value="TDE_2170"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2170"/>
    <dbReference type="HOGENOM" id="CLU_3174428_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="47" mass="5918" checksum="5CCBB0D72BCAE0C8" modified="2004-07-05" version="1">MRKRIPIITISVRLVEMLLMWQRDVWQCRQKYFYLIKKTGIYPFNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KR4</accession>
    <name>Q73KR4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972754.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679989.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2153"/>
    <dbReference type="EnsemblBacteria" id="AAS12673">
        <property type="protein sequence ID" value="AAS12673"/>
        <property type="gene ID" value="TDE_2153"/>
    </dbReference>
    <dbReference type="GeneID" id="2739139"/>
    <dbReference type="KEGG" id="tde:TDE_2153"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2034"/>
    <dbReference type="eggNOG" id="ENOG502ZM78">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116322_0_0_12"/>
    <dbReference type="OMA" id="YREDQKE"/>
    <dbReference type="OrthoDB" id="2051240at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="154" mass="17075" checksum="DCE61D9A3524EDE5" modified="2004-07-05" version="1">MLNLDQVRLLENKVERAVQMIKSLHTEKDALKKEIEARDRRISELEKLIIVFKDDQSKIEEGIINALNQLSAFEDASYTKKHETRPSASEFETAAPVSAGSKPEPFSTPSTKTSSQQAPAADPVSEEPVSSNLQKDLDDVLGQSSDASKQMDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KW1</accession>
    <name>Q73KW1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972707.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679912.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2106"/>
    <dbReference type="EnsemblBacteria" id="AAS12626">
        <property type="protein sequence ID" value="AAS12626"/>
        <property type="gene ID" value="TDE_2106"/>
    </dbReference>
    <dbReference type="GeneID" id="2740345"/>
    <dbReference type="KEGG" id="tde:TDE_2106"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1989"/>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149290_2_0_12"/>
    <dbReference type="OrthoDB" id="2065431at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="95" mass="11525" checksum="2061062F214ABD38" modified="2004-07-05" version="1">MIFEWDEIKNENNIKKHDGISFKIAARVFLDSKRREKYDEQHSTLEEQRWNAIGLVEDVLFVVFTERKNDIIRLISARKANQEEINEYYSNYDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L33</accession>
    <name>Q73L33_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972635.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679810.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12546">
        <property type="protein sequence ID" value="AAS12546"/>
        <property type="gene ID" value="TDE_2032"/>
    </dbReference>
    <dbReference type="GeneID" id="2740379"/>
    <dbReference type="KEGG" id="tde:TDE_2032"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1916"/>
    <dbReference type="eggNOG" id="COG4571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801532_0_0_12"/>
    <dbReference type="OMA" id="GMESTEW"/>
    <dbReference type="OrthoDB" id="1748611at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020080">
        <property type="entry name" value="OM_adhesin/peptidase_omptin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000036">
        <property type="entry name" value="Peptidase_A26_omptin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01278">
        <property type="entry name" value="Omptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69917">
        <property type="entry name" value="SSF69917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="332" mass="37248" checksum="98224EB2710FE0E8" modified="2004-07-05" version="1">MSGFDRRIIILIFLFLSAHSISSEEGKTSFSFSVSPSLIAGSGFEYVFSTDSHIRSKLDWPLLPAGGLTADTEFKLKNGLYFSFISSFIIPAYSGQIFDYDYLNPYDSSMLTHFSEHKAYVKKGLDLNLNIGFMKLLVEYKTSSNKKIRVSCAPSIGIRYILNAWDAMDGYTKYPPDTNPPSPVLPDTPTISVAGLGISYKQSFILPSVGVLFRFELPREWKIDLSTQLCPSAIGFAEDFHYKREDGGLKFVDVFTKKNLSFYLYLSAEKRLSKHFSFFSSIDYTSITAYHGKLFTYYLKSGILKSSSSTGSVGAALYSTRINLGFIFHIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LB8</accession>
    <name>Q73LB8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972550.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1947"/>
    <dbReference type="EnsemblBacteria" id="AAS12461">
        <property type="protein sequence ID" value="AAS12461"/>
        <property type="gene ID" value="TDE_1947"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1947"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1839"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_2_12"/>
    <dbReference type="OMA" id="MIFGNWM"/>
    <dbReference type="OrthoDB" id="1215743at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="310" mass="32875" checksum="52729B3EDEB74A24" modified="2004-07-05" version="1">MVYFNFNISLCYIAYTIPLLVTSLGGLYSERSGVVNLGLEGLMLVGSFAAAITIHLLEGLIPSGLLIPIGLLAAVIMGILYSLLHAFASITLKADQIISGTAINMLAAALTVYTARAILGSGNVRVNSIIRKDIPGLANIPVLGPLFFSQSYWSTWLVLAILVFSWFLLYKTSFGLRLRACGEHPSAVASAGVNVHKMRYFAVCASGALAGLGGAVILVTYSGEFNGSVDGLGFLALAALIFGQWKPLGILGATFFFGFARTVANVSQVIPSLSLIPPVWLKMFPYMVTLIALVLFSKNSAAPKADGEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LI1</accession>
    <name>Q73LI1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972485.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679578.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1882"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12396">
        <property type="protein sequence ID" value="AAS12396"/>
        <property type="gene ID" value="TDE_1882"/>
    </dbReference>
    <dbReference type="GeneID" id="2739111"/>
    <dbReference type="KEGG" id="tde:TDE_1882"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1784"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_12"/>
    <dbReference type="OMA" id="DWVYVVP"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="427" mass="49826" checksum="C5A9E1C30F7D5996" modified="2004-07-05" version="1">MFKLKENFLLGVATASTQIEGGRVNSNWNDFCDRKMTNDGSDVARANMHYEKVEKDTELLKKMGIQTYRMSLEWARIEPEKGKFDTKAIDHYKEELSLLKKAGIRPLISLYHFSHPMWFENSGGFTKKENVEVFLNYVKTCISELGNLCSDYVTINEPNVYAVQSFFLGLWPPEKKSIAKTLKVMNVLIAAHCKAYDLIHEIRKEKGLTDTRVSFAHHMQAFHPKDKNRKADQRAAKRISKIFQDGIMEACFKGEFSFPFKNILNIKKKNYVDFIAINYYSRQAVRGLSYKAFENTPKNDLGWDIYPLGLIECAQTCYNCLPLPIVISENGTCDNKDEFRCRYIYDHLKLISESPLPFEAYYHWCFIDNFEWKEGEAARFGLVHCNYETQERTIKKSGEFYSEMIKKRGVDKSMMEKYIEPCKYNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LN4</accession>
    <name>Q73LN4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972432.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957071.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12343">
        <property type="protein sequence ID" value="AAS12343"/>
        <property type="gene ID" value="TDE_1828"/>
    </dbReference>
    <dbReference type="GeneID" id="2740490"/>
    <dbReference type="KEGG" id="tde:TDE_1828"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1734"/>
    <dbReference type="HOGENOM" id="CLU_1022852_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="272" mass="32095" checksum="9A97D4091838C669" modified="2004-07-05" version="1">MNIYENLATQAITSFFYNEALWKKEIVFDFLLKPFNLQLLDIAEVKAQDNLKGTVPDFTIITKNSEKLRYEVKINNSGLTISEYDKDTRDAYLIRKNYSFREEIPIPKDKILFWEDLFEIIDKKGATTDFARFDLIREYMCEDIHTLLFTPHEVAMLYSPDTIIAVYEMKEKLLEICRKFLDANVTKYEYKGKLDSKYGIGCYFKKKGAPEYDLFIGLSPHAEKYYSIAKYISGDNWDYFELDKEILAKCNTEEELQQEFNKNAEDVMLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LS3</accession>
    <name>Q73LS3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972393.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681200.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1789"/>
    <dbReference type="EnsemblBacteria" id="AAS12304">
        <property type="protein sequence ID" value="AAS12304"/>
        <property type="gene ID" value="TDE_1789"/>
    </dbReference>
    <dbReference type="GeneID" id="2741233"/>
    <dbReference type="KEGG" id="tde:TDE_1789"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1702"/>
    <dbReference type="eggNOG" id="ENOG5033EAK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169602_0_0_12"/>
    <dbReference type="OrthoDB" id="2009568at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="91" mass="10822" checksum="91043E4B990693CA" modified="2004-07-05" version="1">MEESTFDKYIKNDIKQKKKFDKEYNNFLLSEFILEKMEEENISVRELARKAEVSPTIIQKLRNNKTAGKINYQTFLSVVNSLGYRVNIERI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LW1</accession>
    <name>RL21_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplU</name>
        <name type="ordered locus">TDE_1751</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972355.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669481.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73LW1"/>
    <dbReference type="SMR" id="Q73LW1"/>
    <dbReference type="STRING" id="243275.TDE_1751"/>
    <dbReference type="EnsemblBacteria" id="AAS12266">
        <property type="protein sequence ID" value="AAS12266"/>
        <property type="gene ID" value="TDE_1751"/>
    </dbReference>
    <dbReference type="GeneID" id="2740596"/>
    <dbReference type="KEGG" id="tde:TDE_1751"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1674"/>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061463_3_3_12"/>
    <dbReference type="OMA" id="HRQEITR"/>
    <dbReference type="OrthoDB" id="1949059at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000270742" description="50S ribosomal protein L21">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <sequence length="103" mass="11339" checksum="36D33BF091FC1F4C" modified="2004-07-05" version="1">MYALIEYKGKQYKAEKGAKLVVDKLSAESGSKIDIDTVLLISDGDKVTVGTPYVSGAKVSATVGDSFRERKIIVYKHKAKKNYHRTQGHRQAHTCITVDNIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LZ6</accession>
    <name>Q73LZ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972320.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669403.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1716"/>
    <dbReference type="EnsemblBacteria" id="AAS12231">
        <property type="protein sequence ID" value="AAS12231"/>
        <property type="gene ID" value="TDE_1716"/>
    </dbReference>
    <dbReference type="GeneID" id="2740888"/>
    <dbReference type="KEGG" id="tde:TDE_1716"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1641"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_8_5_12"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="125" mass="14102" checksum="4207F9F2A5A5EF5E" modified="2004-07-05" version="1">MFLNSVAIRTDEMEKSLEFYEKVLGFTFNYMMSAAPGKRIAFLTEPDSGMNLELISHDVSKPQNGSRLSLTVQVDQISEAEKYLKAKNVRITAPPRTVKDGKKILTAVDPNGVEIDFIEFKKENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M03</accession>
    <name>Q73M03_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding protein, HU family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972313.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669390.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1709"/>
    <dbReference type="EnsemblBacteria" id="AAS12224">
        <property type="protein sequence ID" value="AAS12224"/>
        <property type="gene ID" value="TDE_1709"/>
    </dbReference>
    <dbReference type="GeneID" id="2740881"/>
    <dbReference type="KEGG" id="tde:TDE_1709"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1634"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_2_3_12"/>
    <dbReference type="OMA" id="MIVRSEL"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="106" mass="12059" checksum="23425EBBCB94217C" modified="2004-07-05" version="1">MKQKRSKIDIIDSVYRNNPQYQLKQINAIANLFLDELSVLLQQGIPVEIRGLGSFDFAVLHGRKNARNPKTGEAVLTADRCKVRFKPGKELKEALHKIDTQELIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M12</accession>
    <name>Q73M12_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972303.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670956.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1699"/>
    <dbReference type="EnsemblBacteria" id="AAS12214">
        <property type="protein sequence ID" value="AAS12214"/>
        <property type="gene ID" value="TDE_1699"/>
    </dbReference>
    <dbReference type="GeneID" id="2740871"/>
    <dbReference type="KEGG" id="tde:TDE_1699"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1625"/>
    <dbReference type="HOGENOM" id="CLU_1098116_0_0_12"/>
    <dbReference type="OMA" id="YSDMFTL"/>
    <dbReference type="OrthoDB" id="2142998at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="244" mass="27803" checksum="D0482D886B8B7D33" modified="2004-07-05" version="1">MLKSGNMRAFFVTIFIVLSFALFSEADVKNMHEFSYGIEADLSRKGRLEAFSYVMNYGFFIPKLSSGLGVKTGSDSISGTLYGKYSPLKLKYFSLGVHAIYNLNLFTGYCIENNFLLGANLSAGKLDKVLFSFDISYLLKLTDFYKLPIIPLIKDNTLALSLKLESLIKDKFLLRFKIASYSMHNYPLFFTPIFSLETAWILSSEIRLNNFFSVKYSDMFTLTSYHSNMMMGISLVFKILPRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M70</accession>
    <name>Q73M70_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sporulation related repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972245.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679323.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1639"/>
    <dbReference type="EnsemblBacteria" id="AAS12156">
        <property type="protein sequence ID" value="AAS12156"/>
        <property type="gene ID" value="TDE_1639"/>
    </dbReference>
    <dbReference type="GeneID" id="2739748"/>
    <dbReference type="KEGG" id="tde:TDE_1639"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1567"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1000922_0_0_12"/>
    <dbReference type="OMA" id="FWIQIAS"/>
    <dbReference type="OrthoDB" id="1321583at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="3">
        <location>
            <begin position="192"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="276" mass="30437" checksum="425E292F4D2F9996" modified="2004-07-05" version="1">MEQKKILWIVLFISLFALIIFGVGLYLYAPFRNKSTMTAAQISDLGRIEADKTDTSVDPLQWTRNPESIPPLEPDSTTLVNIANNITVVNGEGQTGTTETSINVSDLTNTQKDEKTASLPENLAANLNTNQEGNKKNSDTETQTTPAKEANQNTGVASVKGVTSNTVQKPKTEKKTPQKTEKPAVKTSPAQKTVSTLYWVQTASLTSRLNAEAARDTLTSKHMKAEIFTKETATGLTHRVRVGPFKNKTEAEYWLKKIKEIKGFEGSYVTQDRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M78</accession>
    <name>Q73M78_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Citrate lyase alpha chain</fullName>
            <shortName evidence="1">Citrase alpha chain</shortName>
            <ecNumber evidence="1">2.8.3.10</ecNumber>
            <ecNumber evidence="1">4.1.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Citrate (pro-3S)-lyase alpha chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Citrate CoA-transferase subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">citF</name>
        <name evidence="2" type="ordered locus">TDE_1631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + citrate = (3S)-citryl-CoA + acetate</text>
            <dbReference type="Rhea" id="RHEA:19405"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57321"/>
            <dbReference type="EC" id="2.8.3.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>citrate = acetate + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:10760"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="EC" id="4.1.3.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.8.3.10" evidence="1"/>
    <dbReference type="EC" id="4.1.3.6" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972237.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679316.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1631"/>
    <dbReference type="EnsemblBacteria" id="AAS12148">
        <property type="protein sequence ID" value="AAS12148"/>
        <property type="gene ID" value="TDE_1631"/>
    </dbReference>
    <dbReference type="GeneID" id="2739740"/>
    <dbReference type="KEGG" id="tde:TDE_1631"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1559"/>
    <dbReference type="eggNOG" id="COG3051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046521_2_0_12"/>
    <dbReference type="OMA" id="VDYPNYP"/>
    <dbReference type="OrthoDB" id="1099538at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009346">
        <property type="term" value="C:ATP-independent citrate lyase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008815">
        <property type="term" value="F:citrate (pro-3S)-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008814">
        <property type="term" value="F:citrate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006472">
        <property type="entry name" value="Citrate_lyase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40596">
        <property type="entry name" value="PTHR40596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04223">
        <property type="entry name" value="CitF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009451">
        <property type="entry name" value="Citrt_lyas_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01584">
        <property type="entry name" value="citF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="498" mass="53871" checksum="E4A97E636F95E7E3" modified="2004-07-05" version="1">MNNILGREGLDNPFKGAFVNKKNAKYELTKNVKPAFGKNVSQALDEFKLHDGMVISFHHHLRNGDYVLDMVMREIKKRGIKDLTVMASSIFPCHEILVELMEDGTVTQLMTSYMSGPVAKAVSYGKCKKPVIMTTHGGRPRMILEKEVTIDAAFLASPCVDDQGNISGSEGRSFCGSLGYAVADAQMAKKTIAITDTRVSKVKRADIEGRFVDMVVEVDKIGDPAGIVSGTTQITKDPIGLKIARDCRTLIEHSGLFKNGFSMQTGAGGISLAVADEMHRAMKEKNIKGSFGCGGITGYFVKMLEEGLFEDLYDVQCFDLSAVDSIEKNANHHKISADLYANPNNPDHVAGKLDVVILGASEIDLDYNVNVTTGSDGIILGGSGGHADTAAGAKLSIIVSKLFNARISCLVDKVRTVTTPGETIDVFVTDRGIAINPRHADLIKKLKAETNLEIKTIEELKEIAESFTGKPQVKPRSGEVVGISTYRDGTVLDVINKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M87</accession>
    <name>Q73M87_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972228.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1622"/>
    <dbReference type="EnsemblBacteria" id="AAS12139">
        <property type="protein sequence ID" value="AAS12139"/>
        <property type="gene ID" value="TDE_1622"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1622"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1550"/>
    <dbReference type="HOGENOM" id="CLU_3067328_0_0_12"/>
    <dbReference type="OrthoDB" id="1178320at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="53" mass="5869" checksum="156E749EACF89083" modified="2004-07-05" version="1">MPQVLVKAHAALDSAVDKLYRKTAFSDDAARTAFLFELYLKKTEGVLAGKRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ME0</accession>
    <name>Q73ME0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972174.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1568"/>
    <dbReference type="EnsemblBacteria" id="AAS12085">
        <property type="protein sequence ID" value="AAS12085"/>
        <property type="gene ID" value="TDE_1568"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1568"/>
    <dbReference type="HOGENOM" id="CLU_2811183_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="67" mass="8281" checksum="DCBAC8E1F27475BD" modified="2004-07-05" version="1">MIFFYYCKYFKYLIFRTAIESDGGALKSAVLNFVFFIILKNKIEQFAKRRLLLNFWYKKYDHIFDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MJ4</accession>
    <name>Q73MJ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972120.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679164.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1514"/>
    <dbReference type="TCDB" id="3.A.1.122.8">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12031">
        <property type="protein sequence ID" value="AAS12031"/>
        <property type="gene ID" value="TDE_1514"/>
    </dbReference>
    <dbReference type="GeneID" id="2739720"/>
    <dbReference type="KEGG" id="tde:TDE_1514"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1453"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_4_12"/>
    <dbReference type="OMA" id="IFWAFNI"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="329"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="425" mass="46335" checksum="F9E492D3F9DC6DB0" modified="2004-07-05" version="1">MFWRMIAGALFRQKGKMVMIAFTIALGASLSTSMLNTMLGVGDKVNQELKTYGANINVAHKESSLLDDIYGEESGNTKKFLKEDELYKIKTIFWAYNIVDYAPFLNVQVDYDGADKPVRLSGTWFDFRIDLHTGQEVITGIRRMRTWWEVNGNWVSDDDNSSCMVGSLFAGRNNLKVGDEIKLTSAVASKTLKVSAIFNSGSNEDEVIFTTLHTAQEFLGKTNVCESIEVSALTTPDNDLARKAARNPLSLTIKEMEIWYCTAYVSSICYQIQEVITDAVAKPIRQVAESEGAILNKTSLLMLLITVLSLIASALGISNLVTASVMDRRAEIGLKKAIGASNTAVTVSVLTEVMVIGIIGGAAGYFVGLGLTQIIGRSVFGSAIPPAPMVIPIVVLIIFLITLLGSLPSVRYLLKLNPTEVLHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MJ5</accession>
    <name>Q73MJ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972119.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1513"/>
    <dbReference type="EnsemblBacteria" id="AAS12030">
        <property type="protein sequence ID" value="AAS12030"/>
        <property type="gene ID" value="TDE_1513"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1513"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1452"/>
    <dbReference type="HOGENOM" id="CLU_218470_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="44" mass="5073" checksum="C3A5F154EFF718F3" modified="2004-07-05" version="1">MGEVLNSSVQMAPLCLADEFAFRQTSHYCMRFVNKPLEKTFFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MR0</accession>
    <name>Q73MR0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="8" type="ordered locus">TDE_1448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972054.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679098.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1448"/>
    <dbReference type="EnsemblBacteria" id="AAS11965">
        <property type="protein sequence ID" value="AAS11965"/>
        <property type="gene ID" value="TDE_1448"/>
    </dbReference>
    <dbReference type="GeneID" id="2741411"/>
    <dbReference type="KEGG" id="tde:TDE_1448"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1389"/>
    <dbReference type="eggNOG" id="COG0796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052344_2_2_12"/>
    <dbReference type="OMA" id="MPWGPRT"/>
    <dbReference type="OrthoDB" id="1718671at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="13"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="190"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="271" mass="30422" checksum="D519903FAD1870F4" modified="2004-07-05" version="1">MTLKQNVQYVFIDSGIGGLPYLRHLKELEPQSSCAYVADTKHFPYGEKTLEDVIEYTEDLVKKIIEKLKPSVIIIACNTMTVSALSHLRKKFEIPFVGTVPAIKPAALTSKNKKIAVLATERTVNDIYVQNLIEEFGADCKFFMRADSVLVSKIENTLLSGSEEDKKAGIRPAVEFFKSAGTDTAVLGCTHFLHLRDEFKSECEPDIKIVDSLDGVVNQALKISPPQKSKTDEKLKNIQKDIFYITSEKTEESTKKYSAYAELFNMTLGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N27</accession>
    <name>Q73N27_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971935.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668661.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1329"/>
    <dbReference type="EnsemblBacteria" id="AAS11846">
        <property type="protein sequence ID" value="AAS11846"/>
        <property type="gene ID" value="TDE_1329"/>
    </dbReference>
    <dbReference type="GeneID" id="2741063"/>
    <dbReference type="KEGG" id="tde:TDE_1329"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1277"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_437284_0_0_12"/>
    <dbReference type="OMA" id="YRGKIIW"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="328"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="587" mass="66679" checksum="0F41D408602BE15F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N62</accession>
    <name>Q73N62_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971900.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668604.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1293"/>
    <dbReference type="EnsemblBacteria" id="AAS11811">
        <property type="protein sequence ID" value="AAS11811"/>
        <property type="gene ID" value="TDE_1293"/>
    </dbReference>
    <dbReference type="GeneID" id="2741047"/>
    <dbReference type="KEGG" id="tde:TDE_1293"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1242"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_12"/>
    <dbReference type="OMA" id="NVQFQRM"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_M" evidence="3">
        <location>
            <begin position="109"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="229"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="460" mass="50213" checksum="F229797E431FC9E2" modified="2004-07-05" version="1">MKFDDLKSHARLFSEYTELRVQNDSFMTVAAVNGDLINNVQARKAGVCARSFKDGVWGFASSPEQTDEAIASSIKSANENVKFLAKKTGSGQAELPAFTGQGTYGKYDPSKDADQKEAIDFIKDLENYTAKKYPELQSRIFRISANGTERHLITSDKADAHTYISRANLVMSFKLLSEGQPIDLYDVFGGYGQFKNLFDKPNLYYSKIDEMVENLKQKAAGVYAKPGIHDVVLGPDLAGILAHEAIGHTTESDFVMSGSIAADFMNKEVATPLVTLVDFAYECNGKICPVPIWIDDEGVAAKDAVIIKDGILRSYMHNKQSAAIFKVDPTGNARANEFSDEPLVRMRNTAILPGKDKLKDMIASIDDGYYFVRSSNGQADSTSEFMFGVVLGYEIKNGKIGRAVKDCTIAGVAFDMLKTVTMVSDDMSWSNAGMCGKKQLINVGMGGPAIKCKIGVGGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N80</accession>
    <name>Q73N80_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide/dipeptide ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971882.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678777.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1275"/>
    <dbReference type="EnsemblBacteria" id="AAS11793">
        <property type="protein sequence ID" value="AAS11793"/>
        <property type="gene ID" value="TDE_1275"/>
    </dbReference>
    <dbReference type="GeneID" id="2740568"/>
    <dbReference type="KEGG" id="tde:TDE_1275"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1226"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_2_12"/>
    <dbReference type="OMA" id="RKEWYAN"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="317" mass="35295" checksum="E160332EEEBFB6B2" modified="2004-07-05" version="1">MKLKYVIKRLLIAIPTFLGITFFTYLILSMAGSPLDAYLADPRITVMELERKRNSLGLDQPIIIQYFIWLKNFFNMDLGFSFQSQRPVTQMIFERMGITALLAGSSLILSLLISIPLGIFSASKPNSFRDHASSAFSFILVATPNFFMGLILIYFCAIKLRLLPSGGLFDASGKKTTLMLLKHMILPTLVLSFQQIGSWMRYMRGSMLEVLQEDYITTARAKGLKRNQIYYTHALKNSLIPIITVVGMSIPSLVGGAVVTEQVFGWPGIGTLMVQAINAKDYPVIMGITVNISIAVLIANLITDLAYGLVDPRISYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NA6</accession>
    <name>Q73NA6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971856.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678750.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1249"/>
    <dbReference type="EnsemblBacteria" id="AAS11767">
        <property type="protein sequence ID" value="AAS11767"/>
        <property type="gene ID" value="TDE_1249"/>
    </dbReference>
    <dbReference type="GeneID" id="2741425"/>
    <dbReference type="KEGG" id="tde:TDE_1249"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1201"/>
    <dbReference type="eggNOG" id="ENOG5033HFX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_855109_0_0_12"/>
    <dbReference type="OrthoDB" id="1642933at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="311" mass="35726" checksum="295948E7A6677EC7" modified="2004-07-05" version="1">MEGILIPQQVFVGDSAEFLFPIDDLQSFDPSILMSGSFKIDKIKQNTMMDITSIQIKKQKTKEYISINFTPWETGAISFPPLDEAGIYDSIPQVFISSILETAKVEVIQPPRPPLLLPGTSYLLYLIASVSAVFIFTSIMIFSAVKKHFFVYSFSKAQRIRIKVLNKSLRKLKRQVSSVSSSDSLEGITKRKDWLKKFEFAFRRYCFSLTSSEAVLKSGEGESLTYSEILESLKRKFESTYGVYFEFEKIFFKLQALRFGAADLKEINFEMESIYFLNQTFKLMKIAESEIQKIINADQKEKLKYKADTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NI8</accession>
    <name>Q73NI8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971772.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956910.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1164"/>
    <dbReference type="EnsemblBacteria" id="AAS11653">
        <property type="protein sequence ID" value="AAS11653"/>
        <property type="gene ID" value="TDE_1164"/>
    </dbReference>
    <dbReference type="GeneID" id="2741496"/>
    <dbReference type="KEGG" id="tde:TDE_1164"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1123"/>
    <dbReference type="HOGENOM" id="CLU_2636988_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="77" mass="8681" checksum="D63AAE928302F7B2" modified="2004-07-05" version="1">MKTKSADVSSQWNEKRKTVLGLTLTFPSSEEKQKALEFLNSGGRKPAAFMLYLLDKEMERAGLKKMVVGKPADSYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NM5</accession>
    <name>Q73NM5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1127</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971735.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682422.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1127"/>
    <dbReference type="EnsemblBacteria" id="AAS11616">
        <property type="protein sequence ID" value="AAS11616"/>
        <property type="gene ID" value="TDE_1127"/>
    </dbReference>
    <dbReference type="GeneID" id="2739543"/>
    <dbReference type="KEGG" id="tde:TDE_1127"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1088"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024320_0_0_12"/>
    <dbReference type="OMA" id="PSYWDAY"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="373"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="407"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="441"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="577"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="611"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="679"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="725" mass="81379" checksum="8663BD84A5026B9C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NQ2</accession>
    <name>Q73NQ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971708.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1100"/>
    <dbReference type="EnsemblBacteria" id="AAS11589">
        <property type="protein sequence ID" value="AAS11589"/>
        <property type="gene ID" value="TDE_1100"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1100"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1059"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086503_5_0_12"/>
    <dbReference type="OMA" id="CYGMIFD"/>
    <dbReference type="OrthoDB" id="1389691at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="134" mass="15439" checksum="D6EB7B3CF4ED315D" modified="2004-07-05" version="1">MQIKTDIEFSKEEVINLYEEAGWTAYTKNKDKLWQSITSSLKIYSVFVDNEFAAIARVLGDGITTILIQDIIVKQKYQNRGIGTALIKTIVKDYKSVRQTILLCDNDKKLIDFYKKNGLKNIQDYNISCYGILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NQ3</accession>
    <name>Q73NQ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971707.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670641.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1099"/>
    <dbReference type="EnsemblBacteria" id="AAS11588">
        <property type="protein sequence ID" value="AAS11588"/>
        <property type="gene ID" value="TDE_1099"/>
    </dbReference>
    <dbReference type="GeneID" id="2740229"/>
    <dbReference type="KEGG" id="tde:TDE_1099"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1058"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122305_0_1_12"/>
    <dbReference type="OMA" id="YDIRIFP"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="171" mass="19958" checksum="8EE546997438A533" modified="2004-07-05" version="1">MKNVDCNIEKMNEKSYNTIKRDMIKNLAETFIQTKKANELTAISLAEKELNGILTEGVKTKNHNLYVVKKDSQKIGYLWYFIITHNNETFPFVMEINIDKQYRNKGYGKQTMLLLEKETINLGYNKIRLHVLLNNTTAYNMYKNLNYKTIKKIDDGEILEKELNGCLAGHL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NQ6</accession>
    <name>ISPH_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="1">HMBPP reductase</shortName>
            <ecNumber evidence="1">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispH</name>
        <name type="ordered locus">TDE_1096</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971704.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682405.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NQ6"/>
    <dbReference type="SMR" id="Q73NQ6"/>
    <dbReference type="STRING" id="243275.TDE_1096"/>
    <dbReference type="EnsemblBacteria" id="AAS11585">
        <property type="protein sequence ID" value="AAS11585"/>
        <property type="gene ID" value="TDE_1096"/>
    </dbReference>
    <dbReference type="GeneID" id="2740226"/>
    <dbReference type="KEGG" id="tde:TDE_1096"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1055"/>
    <dbReference type="eggNOG" id="COG0761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027486_0_1_12"/>
    <dbReference type="OMA" id="HNKYVVD"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000128885" description="4-hydroxy-3-methylbut-2-enyl diphosphate reductase">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="230"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <sequence length="289" mass="31256" checksum="C869F1A2B41C71EF" modified="2004-07-05" version="1">MVVKRAEVLGYCSGVRRAVDTVLKLAKENTENKSGLYTFGPLIHNPSTMLRLKQMGVRTIDTENFTEDEDYKDSVIVIRAHGIPPSKKSELEKSGAKVIDATCSRVKASQALAKKHSEEAFVILAGDKNHGELISIAGYAEGKCLIVQNAEEAALIDLPSSLSANGSAVLIAQTTIKESEYEAIASALKKRISDLKVFNTICPATSDRQAALKKLAYEVDALLVIGGKNSANTKRLFQTAVDTKKPAWLIEDASEIPKEIFSYSVIGLTAGASTPDFIIDEVEKKLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NR1</accession>
    <name>Q73NR1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971699.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682401.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1091"/>
    <dbReference type="EnsemblBacteria" id="AAS11580">
        <property type="protein sequence ID" value="AAS11580"/>
        <property type="gene ID" value="TDE_1091"/>
    </dbReference>
    <dbReference type="GeneID" id="2739103"/>
    <dbReference type="KEGG" id="tde:TDE_1091"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1050"/>
    <dbReference type="eggNOG" id="ENOG502ZYU8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1111001_0_0_12"/>
    <dbReference type="OMA" id="NRAYICE"/>
    <dbReference type="OrthoDB" id="1809129at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="252" mass="28487" checksum="584B3D30CD15A9C9" modified="2004-07-05" version="1">MIKKPNLFFSILLLIFLSFNIYTQEAASKQEIEQKTEETNEANQAEVLTKVPSDFGFYIGTEMVFSSLKKHAAPPFGVALNLGAEYEYKGIKMLSIVPSLDFSLFHYGFYKNRAYICEIEHRTALTMSFLLDVPFLARLDLKRWTISMGGGLAFFIRFGLLEPGIKPDAAGSDGLTTAKEVREINRYFWQNGRFIYPSLRIKAEYTLTSGWKAGVQLKAYLPFSNLWDKLVNKSSDGLIVQAGIVLHPAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NR3</accession>
    <name>Q73NR3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971697.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670623.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1089"/>
    <dbReference type="EnsemblBacteria" id="AAS11578">
        <property type="protein sequence ID" value="AAS11578"/>
        <property type="gene ID" value="TDE_1089"/>
    </dbReference>
    <dbReference type="GeneID" id="2739101"/>
    <dbReference type="KEGG" id="tde:TDE_1089"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1048"/>
    <dbReference type="eggNOG" id="ENOG50340W9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894126_0_0_12"/>
    <dbReference type="OMA" id="IIYDYTV"/>
    <dbReference type="OrthoDB" id="1058191at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005700777" evidence="1">
        <location>
            <begin position="20"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="324" mass="37796" checksum="0A87CE7EE939EC63" modified="2004-07-05" version="1">MKKILISIFCIIQSLFIFAQNMTESVSKADVSIRFYDRRVYYPGSGASEPIFVQISITNNKSETLRFKLADDRSFSIDFGIINSKNRQLQHTAEWMRKRNTNRQIYFREITLEPGETYSFIENIKDYIEINEPGIFLVNSLFFPELKRYSDNSEAHVISNKLSLEIKPAPSAAALGSLPVSPLSGEILQAKPIPPDQVISYLLTARQKSLWEQFFLYMDLEKMISRDPSRNRRFKAESEAGRMEMVEVYKHELSQERVDKDIAVIPVEFKIEHTGYTDTKAEVKVIEWFEYSNFREKKRFTYFLASKDGIWTVYDYIVENLGTE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NS2</accession>
    <name>RSMA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="1">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmA</name>
        <name evidence="1" type="synonym">ksgA</name>
        <name type="ordered locus">TDE_1080</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971688.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682389.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NS2"/>
    <dbReference type="SMR" id="Q73NS2"/>
    <dbReference type="STRING" id="243275.TDE_1080"/>
    <dbReference type="EnsemblBacteria" id="AAS11569">
        <property type="protein sequence ID" value="AAS11569"/>
        <property type="gene ID" value="TDE_1080"/>
    </dbReference>
    <dbReference type="GeneID" id="2739092"/>
    <dbReference type="KEGG" id="tde:TDE_1080"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1040"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_2_12"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="OrthoDB" id="2030110at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000101633" description="Ribosomal RNA small subunit methyltransferase A">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <sequence length="293" mass="32966" checksum="0FB0804E83259F93" modified="2004-07-05" version="1">MNSGFFLSPPNYDSPAELKSLLETLGFAMQKKFGQNFLIDKKTRENLISFLTLDKGTRVWEVGPGLGAMTYLLLEKGVHLTAFEIDKGFISLLKKIFLENSKQNFTLIEGDVQKNWLPYLIEHGKPNVFFGNLPYNIASDLIASTVEAGVVFDTMLFTVQKEAAERITARPGNKNYTAFSVLCSLFYECKIVKTIPASAFWPQPNVESAAVLFKAKKEFAEYKNFKLFIKIVKALFSSRRKNIKNNLGSWMKSNGYGDKIDLVLERSGLSGNLRAESLALYDFLLLSDIIGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NV2</accession>
    <name>Q73NV2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971658.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670541.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1050"/>
    <dbReference type="EnsemblBacteria" id="AAS11539">
        <property type="protein sequence ID" value="AAS11539"/>
        <property type="gene ID" value="TDE_1050"/>
    </dbReference>
    <dbReference type="GeneID" id="2741324"/>
    <dbReference type="KEGG" id="tde:TDE_1050"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1010"/>
    <dbReference type="eggNOG" id="COG0467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103376_0_0_12"/>
    <dbReference type="OMA" id="KTACLVH"/>
    <dbReference type="OrthoDB" id="1079537at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="227" mass="25014" checksum="534055EBE232F878" modified="2004-07-05" version="1">MLKEDLIEKSPMRKLEKALGGGLAAGEVGVVTSKKGVGKTSILVQFGLDKLLQDKPVVHISFSQHVDYAITWYNDMFNELAKKKNLGNAPEIKAQAFSKRIVLNFNQDTVRTTQILKTIRALSEGGSKPSVVMIDDFNFAKALPEAMKAMKAFAKEMDVAVWYTAAADVASFEIDESLKKYIDDIDVLLYLENDGDFVRIKALKEHGNGASDTGSSFDAKTMLLSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NX2</accession>
    <name>Q73NX2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971638.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682342.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1030"/>
    <dbReference type="EnsemblBacteria" id="AAS11519">
        <property type="protein sequence ID" value="AAS11519"/>
        <property type="gene ID" value="TDE_1030"/>
    </dbReference>
    <dbReference type="GeneID" id="2741508"/>
    <dbReference type="KEGG" id="tde:TDE_1030"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.991"/>
    <dbReference type="eggNOG" id="ENOG5031CPS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1069355_0_0_12"/>
    <dbReference type="OMA" id="IRYRAGH"/>
    <dbReference type="OrthoDB" id="1319194at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="282" mass="32148" checksum="E11E41BF8D3910DC" modified="2004-07-05" version="1">MVSVYRQYENSNSSVLTNSLLRREFLYGLKFFAVQENFMSEQGAVLRMRISLACVEARAVVIDAYIQTDGNLSYLFVLCSSILPPQVFSETVKNILPNAVIEEFYKTQAEGYLESASQEALTKKPIPFFSPAGVNSESNHLLISLFIEHRAVLLENKKGGLLEKSLKKGSRSLLNEASEIRKYSAANLDVDILLFQKENLILSIPVFQIKKIDKDVFQKKFIQIFPEYGGKKIYVDDVFCIKNIDLSKVNFTKRLKRGIYRITIPDAKTILEFNLLVPSMYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P16</accession>
    <name>Q73P16_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971593.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682298.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0984"/>
    <dbReference type="EnsemblBacteria" id="AAS11474">
        <property type="protein sequence ID" value="AAS11474"/>
        <property type="gene ID" value="TDE_0984"/>
    </dbReference>
    <dbReference type="GeneID" id="2740556"/>
    <dbReference type="KEGG" id="tde:TDE_0984"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.946"/>
    <dbReference type="eggNOG" id="COG4239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_4_0_12"/>
    <dbReference type="OMA" id="YAYRICM"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="298"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="499" mass="57191" checksum="15516C5BEBFBE36B" modified="2004-07-05" version="1">MNKADTNKDFLAKLKASWRLFRERTAFSPLTKMRLHRFKQIKRARISLIFILVTYILSLFAELFINNRPILMKIDGKLYFPTYSKVLYARDFGLQLHHELEIDYRAIKSVLKETGRGWLIMPPVPYNPYETDSTAAPLSLSNLNCPVMGIGLDKSGEMPSDDAAEYRWIDVSEIEGIKISQDEDGTKRYIWVKFTENPEKARLSDFASIKRKYLGIAWNKKSSIESEDPKDYTWYKIGSEKGLAQPDGKYTWIRFAKGRSGEMYPPLAPSFKTKHFLGTDSIGRDILARLIYAYRICMSFSLLFVFITYLIGITIGILMGYIGGLFDTLFQRFIEIWEQIPFLYIVMILGSIFHLSFGWLLLVYLVFGWSGKTWTARAMTYRERERDYVLAAKSMGASTMRIVMLHILPNIIVIVVTALPFAISGGISSLTGLDYLGYGLRPPTPSWGELLSMGTSMYKDAPWILSSTVTAFVFVLILITFIGEGLREAFDPKRYTVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P30</accession>
    <name>Q73P30_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TSPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971579.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682280.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0969"/>
    <dbReference type="EnsemblBacteria" id="AAS11460">
        <property type="protein sequence ID" value="AAS11460"/>
        <property type="gene ID" value="TDE_0969"/>
    </dbReference>
    <dbReference type="GeneID" id="2740541"/>
    <dbReference type="KEGG" id="tde:TDE_0969"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.933"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040161_0_0_12"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="TSPc" evidence="2">
        <location>
            <begin position="173"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="411" mass="47037" checksum="7823D7632721D1D5" modified="2004-07-05" version="1">MKKSRIFTVIKCLFLAAFVICTIVISKNRYKISGFISLEESETDYEAFWDFIYNEYPFTEVCERKGADLKKIKEEGYKEIKSSSPRYSQNSYISFYAKLCEDITSRYFTGHLYPASMRDHEYGMTVSDSYFKLYDVDLMNSFYRVKPSYSVNSLIGSDARMVKVDIKIIEEGKIAYVRIDSFRKRGYAKEYIQYKKDMKKFFLDTEKYKHIIIDVSHNGGGSVECYDSDILSYNNIGRNIRQRIYFLCSKNKYTELNPSFKNNQIDIKEVPNIKNANTKKNTIALYEEDAASFQELAPGYAPPKDRRYWLLISGKTASAADRLAGLCKASGFATLVGSNTGGLGHNGRYSPIYMMLPKSGLLIKFDPLYGLNSEGYCSDEVGIAPDIYNLPGKDALETCLEEIRKLGEKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P43</accession>
    <name>Q73P43_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971566.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682265.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0956"/>
    <dbReference type="EnsemblBacteria" id="AAS11447">
        <property type="protein sequence ID" value="AAS11447"/>
        <property type="gene ID" value="TDE_0956"/>
    </dbReference>
    <dbReference type="GeneID" id="2740764"/>
    <dbReference type="KEGG" id="tde:TDE_0956"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.920"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035211_1_2_12"/>
    <dbReference type="OMA" id="RAWGIGQ"/>
    <dbReference type="OrthoDB" id="1720318at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="5">
        <location>
            <begin position="35"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="264" mass="28635" checksum="AF910C0600EE8EBC" modified="2004-07-05" version="1">MQKDKILKKIIVLCFFIFYNFNFFGLAVPSLSGPVVDKAGILSRSEFEKIENFLLDLDQKSKVQIAVLIIPSLEGESIEDYSMQVAEEWKLGDKEKDSGALLVVAVKDKKLRIEVGYGLEENLTDSRSGQIIRNFIAPQFRSGNYGEGIYDGIKAMAAYASEDESLLKEIAVSDEDDEGGFPQALLFFLFVYLMISKFSPGGLFWIFYLLSRSGRAGRSFNGRSSSRGSFFGGSIGRSSGRGFSGGGFSGGGGSFGGGGASGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P89</accession>
    <name>Q73P89_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971520.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682205.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0910"/>
    <dbReference type="EnsemblBacteria" id="AAS11401">
        <property type="protein sequence ID" value="AAS11401"/>
        <property type="gene ID" value="TDE_0910"/>
    </dbReference>
    <dbReference type="GeneID" id="2739950"/>
    <dbReference type="KEGG" id="tde:TDE_0910"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.881"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026290_2_0_12"/>
    <dbReference type="OMA" id="WWLNNGV"/>
    <dbReference type="OrthoDB" id="1921782at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018891">
        <property type="entry name" value="Abortive_phage_infection"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10592">
        <property type="entry name" value="AIPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="570" mass="65908" checksum="39613EF9C7E00603" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P97</accession>
    <name>Q73P97_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2807 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971512.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956832.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0902"/>
    <dbReference type="EnsemblBacteria" id="AAS11393">
        <property type="protein sequence ID" value="AAS11393"/>
        <property type="gene ID" value="TDE_0902"/>
    </dbReference>
    <dbReference type="GeneID" id="2739942"/>
    <dbReference type="KEGG" id="tde:TDE_0902"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.873"/>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072746_2_1_12"/>
    <dbReference type="OMA" id="DHADIKM"/>
    <dbReference type="OrthoDB" id="1418315at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021255">
        <property type="entry name" value="DUF2807"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10988">
        <property type="entry name" value="DUF2807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2807" evidence="1">
        <location>
            <begin position="50"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="250" mass="26590" checksum="D1A26FD19BD4987B" modified="2004-07-05" version="1">MNKVKLIGIVKAAVITALLVICIGCQSFSGSDEVIKGNGKIETKSFPESDFNAVCIKGGWTADIRYSETFSIQIETDENIFPYLDISLTGTTLNIGFKSGYRYSISPTRRKVFITMPSLIKLQTFGSLTGTISSFNMPKDSMSIDISGSGNITARDITVNTLKVDVSGSSDFSATGKAENMIADVSGSGDIKTTDFETEKADISISGSGSAKVWVTRHLKADISGSGSVRYKGNPVIETKSSGSGRISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PA9</accession>
    <name>Q73PA9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971500.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682170.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0890"/>
    <dbReference type="EnsemblBacteria" id="AAS11381">
        <property type="protein sequence ID" value="AAS11381"/>
        <property type="gene ID" value="TDE_0890"/>
    </dbReference>
    <dbReference type="GeneID" id="2739764"/>
    <dbReference type="KEGG" id="tde:TDE_0890"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.860"/>
    <dbReference type="eggNOG" id="ENOG5030P3E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_494258_0_0_12"/>
    <dbReference type="OMA" id="LASEKEW"/>
    <dbReference type="OrthoDB" id="676563at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="544" mass="63756" checksum="7233613370BEFB2F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PB7</accession>
    <name>Q73PB7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ordered locus">TDE_0882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971492.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670215.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0882"/>
    <dbReference type="EnsemblBacteria" id="AAS11373">
        <property type="protein sequence ID" value="AAS11373"/>
        <property type="gene ID" value="TDE_0882"/>
    </dbReference>
    <dbReference type="GeneID" id="2740929"/>
    <dbReference type="KEGG" id="tde:TDE_0882"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.852"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_1_0_12"/>
    <dbReference type="OMA" id="AVKMDKR"/>
    <dbReference type="OrthoDB" id="1940160at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="77" mass="8193" checksum="15489C8B6DC1E87D" modified="2004-07-05" version="1">MQKDLIEYIAKSLVDDPSAVTVSESENEKGTVIELKVASGDIGKVIGKQGRIAKSIRTLLSASAGKSGKRYSLEIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PD5</accession>
    <name>Q73PD5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphohexose mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971474.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682136.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0864"/>
    <dbReference type="EnsemblBacteria" id="AAS11355">
        <property type="protein sequence ID" value="AAS11355"/>
        <property type="gene ID" value="TDE_0864"/>
    </dbReference>
    <dbReference type="GeneID" id="2741375"/>
    <dbReference type="KEGG" id="tde:TDE_0864"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.833"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032204_0_0_12"/>
    <dbReference type="OMA" id="EANLTEM"/>
    <dbReference type="OrthoDB" id="256504at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="2">
        <location>
            <begin position="49"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="3">
        <location>
            <begin position="358"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="617" mass="68887" checksum="44487CEAE4373D84" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PE5</accession>
    <name>Q73PE5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">recX</name>
        <name evidence="5" type="ordered locus">TDE_0854</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971464.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677235.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0854"/>
    <dbReference type="EnsemblBacteria" id="AAS11345">
        <property type="protein sequence ID" value="AAS11345"/>
        <property type="gene ID" value="TDE_0854"/>
    </dbReference>
    <dbReference type="GeneID" id="2741365"/>
    <dbReference type="KEGG" id="tde:TDE_0854"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.823"/>
    <dbReference type="eggNOG" id="COG2137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066607_2_0_12"/>
    <dbReference type="OMA" id="SETIHAN"/>
    <dbReference type="OrthoDB" id="2025178at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="222" mass="25154" checksum="68E4BBE367744E1C" modified="2004-07-05" version="1">MQDEDSSSANVNPFSIADICSTSSDLVKIINSEGVSFVTRPDYFDEDDFDGLVGECGCPISDESLEALLNAVRIYEAECTASAYLYRAEHSRFQLELKLKKKGFLAFEINPALDYLMGIGLLDDERFARAWLNTRVISKKEGRNRLASELAQRGVSFKIVEDVLNEFFSEHSEEDICREALEKQLINRVDKSRLMRKMYRLGFSVSTVNICLEGLENITDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PJ1</accession>
    <name>Q73PJ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971418.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682066.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0808"/>
    <dbReference type="EnsemblBacteria" id="AAS11299">
        <property type="protein sequence ID" value="AAS11299"/>
        <property type="gene ID" value="TDE_0808"/>
    </dbReference>
    <dbReference type="GeneID" id="2739550"/>
    <dbReference type="KEGG" id="tde:TDE_0808"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.780"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111226_4_0_12"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="156" mass="18103" checksum="06F6508DA906B56F" modified="2004-07-05" version="1">MKTNHPTPANIEFKEITPDNWRIINSLSVKKEQKNFAASNVTILARAFVYRKENAKVFAVYHSDKPIGLIMQRDWIDGEKIVCIMDQFMIDKKSQGRGLGKAALQKWLSMIEAEKKYSCVQLCYVEGDIAAKRLYENFGFYEIDKDEDEIIMQKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PN4</accession>
    <name>Q73PN4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971374.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956814.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0764"/>
    <dbReference type="EnsemblBacteria" id="AAS11255">
        <property type="protein sequence ID" value="AAS11255"/>
        <property type="gene ID" value="TDE_0764"/>
    </dbReference>
    <dbReference type="GeneID" id="2740304"/>
    <dbReference type="KEGG" id="tde:TDE_0764"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.737"/>
    <dbReference type="HOGENOM" id="CLU_3141868_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="49" mass="5460" checksum="8005211B45BED3CF" modified="2004-07-05" version="1">MTGLASCEVLKISFLICLNKDGIRLPKRLYGNAKLLKNTDLKPFLGHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PP0</accession>
    <name>Q73PP0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron compound ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_0757</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971368.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669987.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0757"/>
    <dbReference type="EnsemblBacteria" id="AAS11249">
        <property type="protein sequence ID" value="AAS11249"/>
        <property type="gene ID" value="TDE_0757"/>
    </dbReference>
    <dbReference type="GeneID" id="2739876"/>
    <dbReference type="KEGG" id="tde:TDE_0757"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.732"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_1_12"/>
    <dbReference type="OMA" id="AMVYWSF"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="355" mass="37584" checksum="D9A1C673E3FB288F" modified="2004-07-05" version="1">MQNNKNKVLKIVFLSSALLFLLAGLLISIVLSVGFGAVRIAPAEILKIAQFKILGAGSLEGIKKSAIDIVWIVRMPRILLACLTGMGLAVTGVVMQAIVQNSLADPYILGISSGASLGATLAIALGVGAKLGPNYVGLCACFSAFGTALIVINAANIKGRANSAKLLMAGIAISTIFSAFSSFIVFTTKNREAIRSITFWLMGGFGGAKWENLGLLAGVIFLGIFFFMTQYRTLNLMLLGDSVSITLGKDLHIYRQVYLLICSAIVGFLVYNAGIIGFIGLIIPHISRIFWGTNHKNIIPSSVLIGAIILIWADVLARSVSSLGEIPVGVVISLIGSPVFLYLLINKEYGFGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PP9</accession>
    <name>Q73PP9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron compound ABC transporter, periplasmic iron compound-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971359.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682009.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0748"/>
    <dbReference type="EnsemblBacteria" id="AAS11240">
        <property type="protein sequence ID" value="AAS11240"/>
        <property type="gene ID" value="TDE_0748"/>
    </dbReference>
    <dbReference type="GeneID" id="2740302"/>
    <dbReference type="KEGG" id="tde:TDE_0748"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.723"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025776_0_0_12"/>
    <dbReference type="OMA" id="NWYAVGG"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004286030" evidence="1">
        <location>
            <begin position="23"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="92"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="385" mass="43740" checksum="FA812ACAA9E68AF4" modified="2004-07-05" version="1">MKKRIIVWFAAILMLSFTSAWAKGSQEATGKMGLKKIGQLELKYAKSFSVDYYEQGIKKYKDVEGREVWFVPRGKTIEGGENLNVIETPVKSLVILSTVHATLLRPIGELDKVTGTSVQSDTWKIPEIKKGMDDGKIKFVGSKNALDYEMLHALNADAILLTYENMARTPGIISKFNELGLKWIGVSNHQEADPRARLEWIKFAGEITGKEKEANKYYERELAKINAVEEMNKKSANKTTFASAFMSKDIFYVRNAGDYNVKMFEILGIKYIFKDLNPDKNGNTKMNAEEFYKVAEKADFFFYDSVNGSAIKSTSDLIAFAEYLKDLKAVKENMVWGVKPNYYQSADHVADMIEELNKIIHSKPGELTETEYFYLFSKPLSAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PS8</accession>
    <name>Q73PS8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971330.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681954.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0718"/>
    <dbReference type="EnsemblBacteria" id="AAS11211">
        <property type="protein sequence ID" value="AAS11211"/>
        <property type="gene ID" value="TDE_0718"/>
    </dbReference>
    <dbReference type="GeneID" id="2740625"/>
    <dbReference type="KEGG" id="tde:TDE_0718"/>
    <dbReference type="HOGENOM" id="CLU_2811180_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="67" mass="7894" checksum="358830DA3EA8DB9D" modified="2004-07-05" version="1">MKKYFLYLKKGLIWSMLTVALIPFIHYLFVNSWYDWSWFALAIPIFILLGGPLYVAAVEKINTAKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PU7</accession>
    <name>Q73PU7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971311.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669944.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0699"/>
    <dbReference type="EnsemblBacteria" id="AAS11192">
        <property type="protein sequence ID" value="AAS11192"/>
        <property type="gene ID" value="TDE_0699"/>
    </dbReference>
    <dbReference type="GeneID" id="2739821"/>
    <dbReference type="KEGG" id="tde:TDE_0699"/>
    <dbReference type="eggNOG" id="ENOG5031CV2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2637017_0_0_12"/>
    <dbReference type="OrthoDB" id="2064488at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="77" mass="8881" checksum="47DA512D57041F9E" modified="2004-07-05" version="1">MLETVKGYYNGTQIVLDSPVKLRQGQEVVITYRVFKSNLRQTSKINLIKSLVGAIPYTGKSLDDYRKERLKKYESPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PW5</accession>
    <name>Q73PW5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secF</name>
        <name evidence="10" type="ordered locus">TDE_0680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971293.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681892.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0680"/>
    <dbReference type="EnsemblBacteria" id="AAS11174">
        <property type="protein sequence ID" value="AAS11174"/>
        <property type="gene ID" value="TDE_0680"/>
    </dbReference>
    <dbReference type="GeneID" id="2739673"/>
    <dbReference type="KEGG" id="tde:TDE_0680"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.661"/>
    <dbReference type="eggNOG" id="COG0341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050012_0_1_12"/>
    <dbReference type="OMA" id="RMEFNTT"/>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="413" mass="45244" checksum="6D29259770AC4CD4" modified="2004-07-05" version="1">MKKIISFSKFFVPCIILSIGLIAFGIIGYFTKGINFGIDFQAGFIEKVKIAPTAVELSYEGPLTVSFSQGISDISITTTSLDGENKSYVFKFADNPTLKDFADGLASIDGLKVKVTASGNVLLKNLFSNSESSSRLSANVFRLHHLEKGLKPINTDEVRHALSSIPSVSVQQLGTPEDRYFQIRLADDGKYEDANKELRSIINTALNAAYGIENIAVISTDFVGSRFSSSLAQQAILLVGGALVLIFIYAMFRFQWNFSLAAIIALLHDTLIMIMFISWTQMEFNSTTIAAILTIIGYSINDTIVIFDRIREKIHLEPKLECKEILDKALTEVFTRTIITTLTTMVAVVALYLFTTDSMKDFALALIVGLISGTYSSIYVASYFIALTSKGKKAGEMITRGKKAPGELSGAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PX2</accession>
    <name>Q73PX2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971286.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681885.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0673"/>
    <dbReference type="TCDB" id="2.A.7.3.59">
        <property type="family name" value="the drug/metabolite transporter (dmt) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11167">
        <property type="protein sequence ID" value="AAS11167"/>
        <property type="gene ID" value="TDE_0673"/>
    </dbReference>
    <dbReference type="GeneID" id="2739666"/>
    <dbReference type="KEGG" id="tde:TDE_0673"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.654"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042632_0_0_12"/>
    <dbReference type="OMA" id="EPHSHWH"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="EamA_dom"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="153"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="347" mass="38593" checksum="4E3656350B174F0A" modified="2004-07-05" version="1">MNKNIIAIIYAVAAAAFYALNVPCSKILLQNISPVFMAGLLYIGAGLGVGILYLFNFKKEQKSERLDKNYLPYTIGMIFLDIVAPILLMLGVKYGTSSNASLLGNFEIVATALIALIIFKEKVTWRLWIAIFFITASSIILSFENIEGLNFSIGSLFVLGATICWGLENNCTRRMSDKSTYQIVTIKGLCSGFGSIIVAFVSGETDFTLKYIPFALLLGFVSYGLSIFTYIRAQKYLGAAKTSAYYSIAPFIGTFLAFVLLKEKISTKYISALFVMIIGTAFAVYDTLIRKHLHGHRHTFTHTHNGITHTHTISHSHLHNHFISDSKHGHHHSIEELENELKNEIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PX3</accession>
    <name>Q73PX3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971285.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681882.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0672"/>
    <dbReference type="EnsemblBacteria" id="AAS11166">
        <property type="protein sequence ID" value="AAS11166"/>
        <property type="gene ID" value="TDE_0672"/>
    </dbReference>
    <dbReference type="GeneID" id="2739665"/>
    <dbReference type="KEGG" id="tde:TDE_0672"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.653"/>
    <dbReference type="eggNOG" id="ENOG5032V8F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1015422_0_0_12"/>
    <dbReference type="OrthoDB" id="1296440at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="273" mass="31741" checksum="30E0A307784D19A3" modified="2004-07-05" version="1">MLEKKVITINKNKINIDFSELEKEINNSKISSKELVEVVNVKTTIEPVSNELIIFKDNECIANYIIESGNKSNFSSLKFLHLCIRILNNFGLVIDGEIDDSPFKTEKKINQINGIRFQPVLLNAYNNNPENKGMGLFSRGLHFSGFITSSNFRLCCICDECKKSFNIHSYHAGNGYFQYFYSDDGSETLMVPYDAIKDMPGQLCKNISEESVKRIDSQLEKKGYGRFKFYNPFRCPYCKAPYIDFQKHPEIREYEYYANVFLNKEMIEYKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PY8</accession>
    <name>Q73PY8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971270.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681851.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0657"/>
    <dbReference type="EnsemblBacteria" id="AAS11151">
        <property type="protein sequence ID" value="AAS11151"/>
        <property type="gene ID" value="TDE_0657"/>
    </dbReference>
    <dbReference type="GeneID" id="2739205"/>
    <dbReference type="KEGG" id="tde:TDE_0657"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.637"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="ATMLKPN"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="253" mass="28450" checksum="64276548368AA492" modified="2004-07-05" version="1">METLLDVKNIQKIYKSRFSKQGTVALRDVSFSVKKNEFTAIMGESGSGKTTLLNLLATLDKPSSGEIFLKGEPISKIKTKDISAFRRNKLGFVFQDYNLLDQFSVKDNILLPLVLSNYPIDEMNKRLLPLAEALRISSLLEKYPYEISGGQCQRAAAARAFITKPQLILADEPTGALDSKSSDMLLETFSQMNEAGQTIIMVTHSARAASYAKRVLFLRDGNIYYEIYKGDMGQALFRERINEGLFMMNRMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q21</accession>
    <name>Q73Q21_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-3B C17-methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.131</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cobJ</name>
        <name evidence="6" type="ordered locus">TDE_0623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.131" evidence="6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971237.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681809.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0623"/>
    <dbReference type="EnsemblBacteria" id="AAS11118">
        <property type="protein sequence ID" value="AAS11118"/>
        <property type="gene ID" value="TDE_0623"/>
    </dbReference>
    <dbReference type="GeneID" id="2740468"/>
    <dbReference type="KEGG" id="tde:TDE_0623"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.601"/>
    <dbReference type="eggNOG" id="COG1010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047948_2_0_12"/>
    <dbReference type="OMA" id="VWDDRMV"/>
    <dbReference type="OrthoDB" id="1195697at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030789">
        <property type="term" value="F:precorrin-3B C17-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="240" mass="26123" checksum="B4647E9402641FFF" modified="2004-07-05" version="1">MSKLFVVGIGPGGTEYMSAQAVEALKQSEIIVGYSGYIEYIKPFIEGKEVFQTGMTGEIERCKYAVSKAKEGKTVSIISTGDAGLYGMAGPILELAPDLNVEIIPGISAAFAAASRLGAPLMHDTALISLSDRLTDYEVIKKRVGLAAEGDFVIALYNPKSKTRSDYIEEAVNIILKFRAPQTPVGIVKNACRNNEKITVTELQKINYDEIDMFSLIIIGNSNTYIQNGKIITPRGYKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q86</accession>
    <name>Q73Q86_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971171.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681727.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0557"/>
    <dbReference type="EnsemblBacteria" id="AAS11052">
        <property type="protein sequence ID" value="AAS11052"/>
        <property type="gene ID" value="TDE_0557"/>
    </dbReference>
    <dbReference type="GeneID" id="2739802"/>
    <dbReference type="KEGG" id="tde:TDE_0557"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.542"/>
    <dbReference type="eggNOG" id="ENOG50331US">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1531864_0_0_12"/>
    <dbReference type="OrthoDB" id="1448091at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="175" mass="20863" checksum="F63D4FC743702318" modified="2004-07-05" version="1">MAKETNTLKKFLDSEIYSELIRLTDPASIEEKIKDIEISRLHDRLKQRQFLLEGFTCKLSTEKELAEWYLHLIKENKSDIVLWTKEFWKYSNDTPDEYPDGEFAPEEELDEDEKSKLISVGKYTKSCLAMYMLEFDILKNHPEILADYYKRLRIPDAVKYAREMKKLFSRIFGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q98</accession>
    <name>Q73Q98_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971159.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11040">
        <property type="protein sequence ID" value="AAS11040"/>
        <property type="gene ID" value="TDE_0545"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0545"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.530"/>
    <dbReference type="HOGENOM" id="CLU_3334241_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="38" mass="4413" checksum="A25DED2EB3AEBFFF" modified="2004-07-05" version="1">MQVVIFASFESLIIPQEKYTARLVSDIEFAETLPPEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QC2</accession>
    <name>Q73QC2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxylesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971135.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681654.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0521"/>
    <dbReference type="ESTHER" id="trede-TDE0521">
        <property type="family name" value="Carb_B_Bacteria"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11016">
        <property type="protein sequence ID" value="AAS11016"/>
        <property type="gene ID" value="TDE_0521"/>
    </dbReference>
    <dbReference type="GeneID" id="2739258"/>
    <dbReference type="KEGG" id="tde:TDE_0521"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.507"/>
    <dbReference type="eggNOG" id="COG2272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535043_0_0_12"/>
    <dbReference type="OMA" id="WYNGTDW"/>
    <dbReference type="OrthoDB" id="489066at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="498" mass="56975" checksum="D6A2C9C11C3DFEBB" modified="2004-07-05" version="1">MKIIQTEIGKAYANVVGKTKEGTPVYSILSVPYARAERFEYAKILDKQDYSPDMIINRKETVCFPQRKYPLFFNIFMKHHMLRPEFQPLKDTQTENAFVVNIWAPENFTERKPVVVFLHGGGEGSGTVPIYTMEHIAEQGVVAVTITYRIGNFGYMPVFDKGEIKASLAYLDQQTALNWIYNTISSFGGDNTNITLMGHCGGAVAALYHYLNPVSNKLFHKLILCAGNVPILSEFDFAKNEYAKMLSKNHLKGLEELKKLSAKKLMKLKGGQNDIVDGIFFAEHPMKLLERGEFPCMPVLIGSNKDEFSMIELPMFYKALGITKKKKNLKDVLLKKYGEFAETLESEFKSEANGIVDLQIQIMELLIFHSSALFLMETLSKKCPVYGYRMNYIPHLYNGLRGSYHGAELAFFFGTIDKMNIPITDENRKAVISIQKDWIEFIRTGKMKDRTLFNETGKITEYDKDIRTIPFPHAHLIHHIQNSGIADKLRKEYIHNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QD7</accession>
    <name>Q73QD7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-damage-inducible protein J, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971120.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002665927.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0506"/>
    <dbReference type="EnsemblBacteria" id="AAS11001">
        <property type="protein sequence ID" value="AAS11001"/>
        <property type="gene ID" value="TDE_0506"/>
    </dbReference>
    <dbReference type="GeneID" id="2739603"/>
    <dbReference type="KEGG" id="tde:TDE_0506"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.492"/>
    <dbReference type="eggNOG" id="COG3077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154558_5_3_12"/>
    <dbReference type="OMA" id="NMTTAIN"/>
    <dbReference type="OrthoDB" id="2086657at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026262">
        <property type="entry name" value="DinJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38781">
        <property type="entry name" value="PTHR38781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003108">
        <property type="entry name" value="DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="90" mass="10206" checksum="875CA5B39E921EAE" modified="2004-07-05" version="1">MATTNLNIRTDKEMKERAEAIFFELGLNMTTAINIFLRTTIRENGIPFALKLDIPNAITASAIEEGRKIAYDDTVKKYSNIDDLRKALEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QG1</accession>
    <name>Q73QG1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971096.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002665984.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0482"/>
    <dbReference type="EnsemblBacteria" id="AAS10977">
        <property type="protein sequence ID" value="AAS10977"/>
        <property type="gene ID" value="TDE_0482"/>
    </dbReference>
    <dbReference type="GeneID" id="2741387"/>
    <dbReference type="KEGG" id="tde:TDE_0482"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.467"/>
    <dbReference type="eggNOG" id="ENOG502ZN7G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_1_1_12"/>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="72" mass="8395" checksum="4C4DDC0A2176D38D" modified="2004-07-05" version="1">MASVEKIIEKMKNQPNGIRIQEADKVLEYIGYRFDRQKGSHRHYINAQGDVITVKSETPLKACYVKDILKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QG2</accession>
    <name>Q73QG2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971095.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002665986.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0481"/>
    <dbReference type="EnsemblBacteria" id="AAS10976">
        <property type="protein sequence ID" value="AAS10976"/>
        <property type="gene ID" value="TDE_0481"/>
    </dbReference>
    <dbReference type="GeneID" id="2741386"/>
    <dbReference type="KEGG" id="tde:TDE_0481"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.466"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125405_0_0_12"/>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="113" mass="13071" checksum="7871512011AB9BCD" modified="2004-07-05" version="1">MQIKDYLNLPYSIITKKIHDESGVYYYAQVKELDGCQSSGETLEEVYTNIYEAMEGWIEAKLENGFTIPMPQDENNYSGKFLLRLPKSLHKELALNAEHEGVSLNQYVLYRLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-05" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QI7</accession>
    <name>PDXS_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="1">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="1">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxS</name>
        <name type="ordered locus">TDE_0456</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971070.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666038.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73QI7"/>
    <dbReference type="SMR" id="Q73QI7"/>
    <dbReference type="STRING" id="243275.TDE_0456"/>
    <dbReference type="PRIDE" id="Q73QI7"/>
    <dbReference type="EnsemblBacteria" id="AAS10951">
        <property type="protein sequence ID" value="AAS10951"/>
        <property type="gene ID" value="TDE_0456"/>
    </dbReference>
    <dbReference type="GeneID" id="2740753"/>
    <dbReference type="KEGG" id="tde:TDE_0456"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.443"/>
    <dbReference type="eggNOG" id="COG0214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_12"/>
    <dbReference type="OMA" id="RYANRGW"/>
    <dbReference type="OrthoDB" id="784095at2"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_0000109427" description="Pyridoxal 5'-phosphate synthase subunit PdxS">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <sequence length="282" mass="30351" checksum="9A4E24962854A488" modified="2004-07-05" version="1">MDILDKLRGGVIMDVTNPEQAKIAENAGAVAVMALERIPADIRAAGGVSRMSDPKMIKEIIKAVKIPVMAKVRIGHFVEASILEAIGIDFIDESEVLSPADEVYHVDKNKFKVPFVCGARNLGEALRRIQEGAKMIRTKGEAGTGDVIQAVKHMRQIQSEMRQLTCLREDELYVAAKNFQVPYALVEYVHKHGKLPVPNFSAGGVATPADAALMVHLGADGVFVGSGIFKSGDPAKRAAAIVKAVKNYDNPAILAEVSENLGPAMVGINEEEIKVIMSERGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QK1</accession>
    <name>Q73QK1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971056.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956745.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0442"/>
    <dbReference type="EnsemblBacteria" id="AAS10937">
        <property type="protein sequence ID" value="AAS10937"/>
        <property type="gene ID" value="TDE_0442"/>
    </dbReference>
    <dbReference type="GeneID" id="2740424"/>
    <dbReference type="KEGG" id="tde:TDE_0442"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.429"/>
    <dbReference type="eggNOG" id="ENOG5031CPQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_806408_0_0_12"/>
    <dbReference type="OrthoDB" id="1368801at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="344" mass="40044" checksum="27A6B079230195BD" modified="2004-07-05" version="1">MKKNCLSILLIGFLCMNLFSQSYDERRILFGENYQAIQKISKERESIIKDSYSEVLAFANKFHIFSDSSLVEHGIYKEVHNSFVFYRFLFTDNHSYGTFVFNYLQIFCLAYKNKLYVLGSSYLHEAHLIEETIHVAEENIYSNYSVIQEDDDFEIIMHKTKDKTESYDDGESDSESTVEVSGDGKAYFYKLSDILKTIEKNYSKAGSIVQVELKDYKSVSCGRTLIDEKCPFMYTIQNAFDKNPETAYVENTEDNEITISIFSDKKIKRVGIINGFVKSSNLYESNNRIREMYINDKIFELKDVHSKDFVFFGIPLSSDIYIQTVELYKGNRYSDTCIAEIQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QK9</accession>
    <name>Q73QK9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971048.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681498.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0434"/>
    <dbReference type="EnsemblBacteria" id="AAS10929">
        <property type="protein sequence ID" value="AAS10929"/>
        <property type="gene ID" value="TDE_0434"/>
    </dbReference>
    <dbReference type="GeneID" id="2740580"/>
    <dbReference type="KEGG" id="tde:TDE_0434"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.421"/>
    <dbReference type="eggNOG" id="COG1592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095256_0_0_12"/>
    <dbReference type="OMA" id="PQAYFEV"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="191" mass="21500" checksum="9714A5B5650679DD" modified="2004-07-05" version="1">MQSLKGTKTEQNILSAFIGESQARNKYTFWASTAEKEGFVQIARIFIETAEQEREHAKRLFNFLEGGEVTVSAAAPAGVVGTTLENLRQAAAGENHEWQHMYPEFAKTAREEGFPLIAAVMESIAVAEKYHAERYEAFIKRLEENSMWVQESPTTWKCLNCGFIVVSKNAPEKCPACAHPKAYFARLEESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QL7</accession>
    <name>Q73QL7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacteriocin ABC transporter, bacteriocin-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971040.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681482.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0426"/>
    <dbReference type="EnsemblBacteria" id="AAS10921">
        <property type="protein sequence ID" value="AAS10921"/>
        <property type="gene ID" value="TDE_0426"/>
    </dbReference>
    <dbReference type="GeneID" id="2739590"/>
    <dbReference type="KEGG" id="tde:TDE_0426"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.413"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023976_7_1_12"/>
    <dbReference type="OMA" id="FPIVPGM"/>
    <dbReference type="OrthoDB" id="1395473at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="383" mass="44186" checksum="19793F21826D0736" modified="2004-07-05" version="1">MNPIRLIHLKDLRYKHEIFLQKPPVVLTVFIYIIGSLMLFAFLYCIFGKMEEVVYAKGQVRPVQNISLVKNIIAGEIVQINYLPGQKIEKGVELVKIDDSIYSARKEALQAYYDEINKKIEGLKNLIKSYHADKNLISKTDSSTYARFRVYVNEKEILTKRYNMVKKLWLEALELPATAIQQAQLRELKYKADMAELDLTTYKNKFINSLLSELDNFLIEKEKIYSQLKDANLSLKNTCIRSPISGYVQEISSLNKGDYINVGQSILNIVPDGTDNYKIEIRVPAKDAGKIMEKMKIKYRFTAFPYHEFGGGTGEVVNIEPDSFVARDGSVYFAVTGTLDKNVLLDKEKKEYFVKPGFEIDARIILREQSILWHFLKTMDLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QS4</accession>
    <name>Q73QS4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hsdM-1</name>
        <name evidence="6" type="ordered locus">TDE_0369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970983.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681381.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0369"/>
    <dbReference type="REBASE" id="6417">
        <property type="entry name" value="M.TdeVI"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10864">
        <property type="protein sequence ID" value="AAS10864"/>
        <property type="gene ID" value="TDE_0369"/>
    </dbReference>
    <dbReference type="GeneID" id="2740121"/>
    <dbReference type="KEGG" id="tde:TDE_0369"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.359"/>
    <dbReference type="eggNOG" id="COG0286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013049_6_0_12"/>
    <dbReference type="OMA" id="FVIQKTY"/>
    <dbReference type="OrthoDB" id="791672at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022749">
        <property type="entry name" value="D12N6_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003356">
        <property type="entry name" value="DNA_methylase_A-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004546">
        <property type="entry name" value="Restrct_endonuc_T1M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038333">
        <property type="entry name" value="T1MK-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12161">
        <property type="entry name" value="HsdM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02384">
        <property type="entry name" value="N6_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00497">
        <property type="entry name" value="hsdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HsdM_N" evidence="5">
        <location>
            <begin position="11"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="N6_Mtase" evidence="4">
        <location>
            <begin position="137"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="839"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="871" mass="99132" checksum="A99472820E9E780A" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R00</accession>
    <name>Q73R00_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970907.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681233.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0293"/>
    <dbReference type="EnsemblBacteria" id="AAS10788">
        <property type="protein sequence ID" value="AAS10788"/>
        <property type="gene ID" value="TDE_0293"/>
    </dbReference>
    <dbReference type="GeneID" id="2741384"/>
    <dbReference type="KEGG" id="tde:TDE_0293"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.282"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_12"/>
    <dbReference type="OMA" id="GPIIGQN"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="467" mass="51706" checksum="EAE5467F7C453EAE" modified="2004-07-05" version="1">MENLSCSKCVCDETGLQLKPKKISKNLWKLAYPTMISAGLQNFYDIVDMVWVGQISKTALSGVTLFSSIYMLFTILNEVAGASSVSMISQNYGRGDMEKTQRIAEQTISFKVVLAIMSAFLLAIFLKPILWFFLPDQEVLNSALEYGWLRIFFIPVMFSSYSVNTIFRCTGDAKTPLHIMIISTIINLVLDPVFMFDIIPGTNIPGLGMGVFGAALATVTARTISFLYGFLILLSGRRKVKISFKGLFKLDKKIDTDLLLIGLPSGINSLVRSFAQVTIMKFVTVYGADAVALAGVGGKLSQFAFMPIFGFNMGGATLVGQSLGRDNVKEAKLTSKINAFMSASVVGIFAVIIMGMPQTFLRFFFPNDPSMLLQGSLMLRIFYPSFIILSMGLGLAVVFSGSGHTRPILYSTLGSRWFVQIPFLFLVVNILHLPLFAVWTSYIFSEAAEFMVILYHYRKGAWCNKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R04</accession>
    <name>Q73R04_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0289</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970903.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681230.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0289"/>
    <dbReference type="EnsemblBacteria" id="AAS10784">
        <property type="protein sequence ID" value="AAS10784"/>
        <property type="gene ID" value="TDE_0289"/>
    </dbReference>
    <dbReference type="GeneID" id="2741380"/>
    <dbReference type="KEGG" id="tde:TDE_0289"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.279"/>
    <dbReference type="eggNOG" id="ENOG5032SRY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1347878_0_0_12"/>
    <dbReference type="OrthoDB" id="1551214at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="191" mass="22987" checksum="EAE9094B3DFB5A8F" modified="2004-07-05" version="1">MTIKEFENKYWYMSELKALAKSLEIPFDSRTRKDQLEDMIIQFLEIGTVNKKNSFRIKNRNIDILNNHSYVKNFRNKKETWEFINSEMDKRVPGLKPKSGAKYWLNRWIENKLSNGEKITYNDVVCEYIRLNKTEEKLPQIPSCKFNNFISDYLANEKNATRKDALEAWTMLKDMKVKKDYITWKKINIHK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-21" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R11</accession>
    <name>Y282_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>Putative ABC transporter ATP-binding protein TDE_0282</fullName>
            <ecNumber>7.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_0282</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970896.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681219.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73R11"/>
    <dbReference type="SMR" id="Q73R11"/>
    <dbReference type="STRING" id="243275.TDE_0282"/>
    <dbReference type="PRIDE" id="Q73R11"/>
    <dbReference type="EnsemblBacteria" id="AAS10777">
        <property type="protein sequence ID" value="AAS10777"/>
        <property type="gene ID" value="TDE_0282"/>
    </dbReference>
    <dbReference type="GeneID" id="2741599"/>
    <dbReference type="KEGG" id="tde:TDE_0282"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.272"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_12"/>
    <dbReference type="OMA" id="CHCVSGP"/>
    <dbReference type="OrthoDB" id="870493at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092121" description="Putative ABC transporter ATP-binding protein TDE_0282">
        <location>
            <begin position="1"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="2">
        <location>
            <begin position="269"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="301"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="489" mass="54061" checksum="C9BB3D9A9767C409" modified="2004-07-05" version="1">MITLRNISFSYNGTKENNLCDISLHIPKGQCVLLCGASGCGKTTLTRLINGLIPHFFEGEFSGEAIINGMNSEEADIAQLSDSVGTVFQNPRTQFFNTDTDSEIVFGLENRGLPPEQLLSRLEKVTEDLQIQNLRERSIFELSGGEKQKIAFASVYAAAPDIFVLDEPSSNMDYHSIKELSELIKKIKLQGKTIIIAEHRIWYLMDIADRVIFMENGKIAHDMDIKTFVDLPEAQIKSMKLRCRNLADVKAETVNVSPDVSVSFGGHTFAVKDITVKLGHTSVLQDISFSTTGGEIIAITGENGAGKTTLARTLCGLTQEAAGSISFDGNPLSRKMRRERSYMVMQDVGHQLFTDSVYAECRLGIKDLPDPAIDEVLTELSLNRLKERHPLSLSGGQKQRLAVAVSVLCGKDILIFDEPTSGLDLKSMQEAGRIIKRLADDKKTVIVITHDIEFIKTICSRVLILSGGKIVKELCGEKKNELEMQLETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R13</accession>
    <name>Q73R13_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970894.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681217.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0280"/>
    <dbReference type="EnsemblBacteria" id="AAS10775">
        <property type="protein sequence ID" value="AAS10775"/>
        <property type="gene ID" value="TDE_0280"/>
    </dbReference>
    <dbReference type="GeneID" id="2741597"/>
    <dbReference type="KEGG" id="tde:TDE_0280"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.270"/>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_1_3_12"/>
    <dbReference type="OMA" id="KIPFGIT"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="133" mass="15389" checksum="B6C2421A6B605A8A" modified="2004-07-05" version="1">MILVDTSVLINFFRGRKTVGTTYFEKLIEEEKHFCINEFIYQEILQGAKDEKEFAILKSYLIDVPLYSLRLGIQSFENAALLNFRCRRKGFTIRSTVDLLIAETAIENNIPLLHDDDDFVKIAKIITELKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R25</accession>
    <name>Q73R25_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970882.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669601.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0268"/>
    <dbReference type="EnsemblBacteria" id="AAS10763">
        <property type="protein sequence ID" value="AAS10763"/>
        <property type="gene ID" value="TDE_0268"/>
    </dbReference>
    <dbReference type="GeneID" id="2741252"/>
    <dbReference type="KEGG" id="tde:TDE_0268"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.261"/>
    <dbReference type="HOGENOM" id="CLU_087950_0_0_12"/>
    <dbReference type="OrthoDB" id="2107356at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="276" mass="32853" checksum="B17339F7DE29F6B1" modified="2004-07-05" version="1">MKNKVCFVITFVTTLIYSAYAQDKIDYLVLNKIKIAQEIIVENIKTKVTVKLDENQKKEFLNNLSVVKSRDWGKCLLPYKVSIIYDDKNISFRTNGKTLGQFGTMAIYDFESDLKLLINSFFIMENEFPLYLEKMVKVKNQDIRLYQVNYSRKNLKFIQGFSSSKTLDETHCIWKIGQELIDIQSSFTEKELKKHIKKENLKEVADYYIKELCKRDLFFSTYELHPIDEANEKWIIYFVYVEKEHKDKKEYWDEVVFMLPDGTIVISENNFEEITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RA6</accession>
    <name>Q73RA6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter, ATP-binding protein, HlyB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_0185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970801.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956692.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0185"/>
    <dbReference type="EnsemblBacteria" id="AAS10682">
        <property type="protein sequence ID" value="AAS10682"/>
        <property type="gene ID" value="TDE_0185"/>
    </dbReference>
    <dbReference type="GeneID" id="2741032"/>
    <dbReference type="KEGG" id="tde:TDE_0185"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.181"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="342"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="375"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="585" mass="66166" checksum="5D74ABFBCD6B3C48" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RC5</accession>
    <name>Q73RC5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970781.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681046.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0165"/>
    <dbReference type="EnsemblBacteria" id="AAS10662">
        <property type="protein sequence ID" value="AAS10662"/>
        <property type="gene ID" value="TDE_0165"/>
    </dbReference>
    <dbReference type="GeneID" id="2739598"/>
    <dbReference type="KEGG" id="tde:TDE_0165"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.162"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057504_0_2_12"/>
    <dbReference type="OMA" id="IKRGMEK"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="284" mass="33437" checksum="5669B6C0F65C8616" modified="2004-07-05" version="1">MKQLFKITLRNDYAFKRVFGVEENKDVLQDLLECVLDIPPETIAGLELLDKEFHKELLSEKLGILDIKLRLKDGAFVDIEIQNSWHFDFPERTLYYWSKMYNENIKQGQDYTKLPKCITINLIGKGFNKNKRLHNKYLVLEQDTKEPLVSKLEIHILNLEKARLLKKSQYKDNKTKRLLNWLKFIETDNVEVRNMLAQESQMMRKANETITIMEMSPRDKWLYDSRMKYEHDRASCINEGYQRGLDKGAHQKALETAKAFKQFGFDINKIAEGTGLPVEEIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RE3</accession>
    <name>Q73RE3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970763.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681015.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0146"/>
    <dbReference type="EnsemblBacteria" id="AAS10644">
        <property type="protein sequence ID" value="AAS10644"/>
        <property type="gene ID" value="TDE_0146"/>
    </dbReference>
    <dbReference type="GeneID" id="2739301"/>
    <dbReference type="KEGG" id="tde:TDE_0146"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.144"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_12"/>
    <dbReference type="OMA" id="GLHNAPE"/>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="191"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="400" mass="43779" checksum="16501B50B23ADA3C" modified="2004-07-05" version="1">MYNIIDLVKQKEAKIIQIRRDLHQIPELELSLPKTVDYVCKQLDALQIPYHKLVNGNAIVALIEGKEKGKCIAIRADMDALPIKENTGLSFASKHEGCMHACGHDGHMAMALGACMVLKELSSEFKGCVKILFQPGEEYPGGALPMIEEGCMENPKVDAVIGLHAGYIYPGVEKGKIGACKGPFFAAADKFKIIVKGYGAHGAYPHLSVDPVPIACEIVSGLQKIISRELPPTSHALISVGQIHGGSAFNIIPEEVFIEGTVRSADEKERSFIAKRIEDLASGISKSYRAEAKTVYDFRYPVLLNDKGFTEFFIESTKEILGEDSIHEISVPTMAGEDMAYFLQKAPGTFFVLSNPIIQKDGSIYPHHSDKFDMDESLFYKGTSAVLAAVLKYLNLGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RH4</accession>
    <name>Q73RH4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970731.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673217.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0114"/>
    <dbReference type="EnsemblBacteria" id="AAS10612">
        <property type="protein sequence ID" value="AAS10612"/>
        <property type="gene ID" value="TDE_0114"/>
    </dbReference>
    <dbReference type="GeneID" id="2741729"/>
    <dbReference type="KEGG" id="tde:TDE_0114"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.114"/>
    <dbReference type="eggNOG" id="COG1321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_3_2_12"/>
    <dbReference type="OMA" id="SWDAIDR"/>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="139" mass="15630" checksum="4A786A240172666B" modified="2004-07-05" version="1">MNKRIHVTGTITSSKEDYLERIYDLSLIDEQVRSIDVARALNVSRASVNKSLGGLKEDGYIEQEPYGTITLTKKGRAIAKDVRTRHNALRTFLTQVLKVDYEIADVDACEMEHAISKHTADKLYAYLKKLGITEDDAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RL4</accession>
    <name>Q73RL4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970691.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673282.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0074"/>
    <dbReference type="EnsemblBacteria" id="AAS10572">
        <property type="protein sequence ID" value="AAS10572"/>
        <property type="gene ID" value="TDE_0074"/>
    </dbReference>
    <dbReference type="GeneID" id="2741689"/>
    <dbReference type="KEGG" id="tde:TDE_0074"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.75"/>
    <dbReference type="eggNOG" id="COG1113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_12"/>
    <dbReference type="OMA" id="WWVGSRG"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="447" mass="47761" checksum="3EB3E7701AA15223" modified="2004-07-05" version="1">MKIKENEKLGLGSCVTILVGGCIGSAIFSLSGMTMYYAGPAALITWFVAALILGLYGIQVAELSIRYPKSGGVFVFPAKAMGKNEREGKVWGFISAWGYVISNIIAVAFSAIYVAVYLGVGFQALAGFRIPLAIISIVICTALNLIKVTSAGKYNNVLVALLVITMLTFVSIAMFAGRWNPQNMVPFFTQGAKGVAGFIQAIPNAMVGYGSVVAIAFMVGEVENPNRTVPKSLAISLILVVLLYQLMILGTMGNITTEFLIKNPGMRFIPMFAAAFTSLNMFPWLSKLISISALLALLTTMLVVGFLNARAVCSMANAKMLPAFFGKVNKNGVPSTACLTLSACTIVLSCFPSITELLVNLGSISAAITIVIVCFSLIASRKKLPHVEGNYAAPGGNIVSILTIILILVCYIPAIFNGSVYMWLFTFILYGIGGIIMFIMMKKNKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RL7</accession>
    <name>Q73RL7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, U32 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970688.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680923.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0071"/>
    <dbReference type="MEROPS" id="U32.003"/>
    <dbReference type="EnsemblBacteria" id="AAS10569">
        <property type="protein sequence ID" value="AAS10569"/>
        <property type="gene ID" value="TDE_0071"/>
    </dbReference>
    <dbReference type="GeneID" id="2741686"/>
    <dbReference type="KEGG" id="tde:TDE_0071"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.72"/>
    <dbReference type="eggNOG" id="COG0826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011540_4_1_12"/>
    <dbReference type="OMA" id="STQMNIA"/>
    <dbReference type="OrthoDB" id="1264653at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="746" mass="84078" checksum="3F6F586FA8B52A9C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J03</accession>
    <name>Q73J03_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973372.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2774"/>
    <dbReference type="EnsemblBacteria" id="AAS13291">
        <property type="protein sequence ID" value="AAS13291"/>
        <property type="gene ID" value="TDE_2774"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2774"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2618"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2921409_0_0_12"/>
    <dbReference type="OrthoDB" id="1909983at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="61" mass="7174" checksum="01CA8D5A6239B06C" modified="2004-07-05" version="1">MQFIKNAYKNTDIKFTCKDMKISNSGNRIAACLINDKGNISIDIFDFKDNLIYREYEFILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J42</accession>
    <name>Q73J42_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4469 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973332.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680792.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2734"/>
    <dbReference type="EnsemblBacteria" id="AAS13251">
        <property type="protein sequence ID" value="AAS13251"/>
        <property type="gene ID" value="TDE_2734"/>
    </dbReference>
    <dbReference type="GeneID" id="2740953"/>
    <dbReference type="KEGG" id="tde:TDE_2734"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2581"/>
    <dbReference type="eggNOG" id="ENOG503295Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092785_0_0_12"/>
    <dbReference type="OMA" id="CHSSQTM"/>
    <dbReference type="OrthoDB" id="1207078at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd12843">
        <property type="entry name" value="Bvu_2165_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027824">
        <property type="entry name" value="DUF4469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14734">
        <property type="entry name" value="DUF4469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4469" evidence="1">
        <location>
            <begin position="130"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="236" mass="25442" checksum="74D906E338698112" modified="2004-07-05" version="1">MLKYCLRENLLTPAPDDYMAQAQDVRSYTLDEIIDLMMEKGTTLTRADVAATLQVYGEVVSAIIKDGSAVNTPLMNTSMSISGVFDGANDSFDKKRHTINLNLTAGTLLRDAVTKIKCEKTESAGTDPYITEVTDVVSGKVNEVLSKGGVVQLVGSRLKFDAKDAAQGIFFVPETGEAVRATVIAENKPARLMAIIPAGLKAGTYYIEVRTKIDMGGKKLKTLKTGRFAKPLTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JA2</accession>
    <name>Q73JA2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973271.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667131.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2673"/>
    <dbReference type="EnsemblBacteria" id="AAS13190">
        <property type="protein sequence ID" value="AAS13190"/>
        <property type="gene ID" value="TDE_2673"/>
    </dbReference>
    <dbReference type="GeneID" id="2741118"/>
    <dbReference type="KEGG" id="tde:TDE_2673"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2525"/>
    <dbReference type="eggNOG" id="ENOG5031CH0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1179786_0_0_12"/>
    <dbReference type="OrthoDB" id="1680791at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024471">
        <property type="entry name" value="DUF2715"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10895">
        <property type="entry name" value="DUF2715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285908" evidence="1">
        <location>
            <begin position="21"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="235" mass="25505" checksum="6825E63FF06F7A60" modified="2004-07-05" version="1">MKHKKIVLVLIILAASAVFAFADFAISFGPAFTNYFVHTKNEGNFSTFSNDVQNALKNAKDEKNNAAGVAVDLRAGFIYLMAQIAFPGKNHTDLMKGATAEKDKFVVKNAFILDSQLGVGITLFKKTPFNLFLGGGLGLNAMKATQTVSIASQDISYDKLDVMFGVGVNVLASFYFTDMIGIYGGIADTVYFAPLKVKKTFKVGNQEYTVSNTKNNIKEVIANSVNLKLGLSIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JD6</accession>
    <name>Q73JD6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oligoendopeptidase F</fullName>
            <ecNumber evidence="6">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pepF</name>
        <name evidence="9" type="ordered locus">TDE_2639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Has oligopeptidase activity and degrades a variety of small bioactive peptides.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973237.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2639"/>
    <dbReference type="EnsemblBacteria" id="AAS13156">
        <property type="protein sequence ID" value="AAS13156"/>
        <property type="gene ID" value="TDE_2639"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2639"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2495"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021290_2_0_12"/>
    <dbReference type="OMA" id="YRQTMFA"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004438">
        <property type="entry name" value="Peptidase_M3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00181">
        <property type="entry name" value="pepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="138"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="230"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS13156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="629" mass="71383" checksum="602BF62F7044A7C5" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JF2</accession>
    <name>Q73JF2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973221.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676089.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2623"/>
    <dbReference type="TCDB" id="3.A.1.31.2">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13140">
        <property type="protein sequence ID" value="AAS13140"/>
        <property type="gene ID" value="TDE_2623"/>
    </dbReference>
    <dbReference type="GeneID" id="2740797"/>
    <dbReference type="KEGG" id="tde:TDE_2623"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2479"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076847_1_1_12"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS13140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="246" mass="27088" checksum="BB8C1D52CC69C719" modified="2004-07-05" version="1">MIAYSSALSQEKRRGFLDPRTKLALVLVLAVFVMGGLGGSQMKSIKIILSVLPFLLLLIERQWKRFGRGVIMLAVGYGLLIAMPHLPGLLNFIALMCGGILTRFAVTVVMGGYLIGTTSVSEFISAMERLHIPQAITIPMSVMFRMFPTIGAEWKSIRRAMGMRGIRLGGVRPGEVVEYQLVPMITSTVRIGEDLSAAALTRGLGSPIKRTNICRIGFRVQDLILLIICLAVVVMWILELCRVALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JG1</accession>
    <name>Q73JG1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_2614</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973212.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680621.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2614"/>
    <dbReference type="EnsemblBacteria" id="AAS13131">
        <property type="protein sequence ID" value="AAS13131"/>
        <property type="gene ID" value="TDE_2614"/>
    </dbReference>
    <dbReference type="GeneID" id="2740788"/>
    <dbReference type="KEGG" id="tde:TDE_2614"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2471"/>
    <dbReference type="eggNOG" id="COG1477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044403_1_0_12"/>
    <dbReference type="OMA" id="MGTFWRV"/>
    <dbReference type="OrthoDB" id="2021063at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS13131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="371" mass="41190" checksum="19B3AED85889A577" modified="2004-07-05" version="1">MFKKSIFLLFLAFYILLAFSCRPAIKEYSKTWLSIGTVCRVRILTSEPQKKAEEVLEKVYAELIKLDSIFNANTDKISAENNNLKGLTTANESELERLNKEAGLSPLEVSHELYELLQISLMMAELTDGAFNPAIGPLVKLWNIGFENESVPSPEDIKEVLPLLDYKNIILSEGNKAFLQKEGMRLDLGGIAKGYAADKIAKILLEHGIKDFLIDLGGNILVSGKNPSGKTWKTALRNPIIGKQNPVVSMNLQDASLVTSGNYERFIEKDGIIYHHIFDSKTGYPVQNSLNASSIVSESSTLADALSTSSYVLGEEKTRALLQKLITVDFPLIGKPKMPACILFYKDNSISVFGNDEISVEIIDQNFFIKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JJ0</accession>
    <name>RL33_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmG</name>
        <name type="ordered locus">TDE_2428</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973027.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667594.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JJ0"/>
    <dbReference type="SMR" id="Q73JJ0"/>
    <dbReference type="STRING" id="243275.TDE_2428"/>
    <dbReference type="EnsemblBacteria" id="AAS12946">
        <property type="protein sequence ID" value="AAS12946"/>
        <property type="gene ID" value="TDE_2428"/>
    </dbReference>
    <dbReference type="GeneID" id="2739853"/>
    <dbReference type="KEGG" id="tde:TDE_2428"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2295"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_0_2_12"/>
    <dbReference type="OMA" id="RYTTMKN"/>
    <dbReference type="OrthoDB" id="2034291at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000356769" description="50S ribosomal protein L33">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <sequence length="56" mass="6644" checksum="AB08EA7E48976924" modified="2004-07-05" version="1">MAKKTAVELIALQCSECKRRNYTTSKNRKNIQGKLELMKYCSFDRKHTLHKETKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JK6</accession>
    <name>Q73JK6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973011.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680348.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2412"/>
    <dbReference type="EnsemblBacteria" id="AAS12930">
        <property type="protein sequence ID" value="AAS12930"/>
        <property type="gene ID" value="TDE_2412"/>
    </dbReference>
    <dbReference type="GeneID" id="2739837"/>
    <dbReference type="KEGG" id="tde:TDE_2412"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2278"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_36_2_12"/>
    <dbReference type="OMA" id="ECVLNDY"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="155" mass="18595" checksum="033C487914B3D43D" modified="2004-07-05" version="1">MDLNFRLSKDAEHIALMSKDVQELHYRLYPEYFKPFSYDEILNFFKKQLQEENWFCYIVSCDGKDAGYALFYIRDYQENPFRKAYRGIHIDQIGIAPEYRQKGIGKAFIKEIEKIAVKEKASQIELTHWELNEDAKCFYESLGFDTYIRFVVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JN8</accession>
    <name>Q73JN8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973043.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680392.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2444"/>
    <dbReference type="EnsemblBacteria" id="AAS12962">
        <property type="protein sequence ID" value="AAS12962"/>
        <property type="gene ID" value="TDE_2444"/>
    </dbReference>
    <dbReference type="GeneID" id="2739629"/>
    <dbReference type="KEGG" id="tde:TDE_2444"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2312"/>
    <dbReference type="HOGENOM" id="CLU_1703450_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="157" mass="18229" checksum="75FB6349D5B8DFD0" modified="2004-07-05" version="1">MGNKITDIMDQVYGSMLVDIYKCVCKALGVDPAIGSEESWRMTKELVNKVMRVFGGEYERIPRTWIENHLNDPNYSSEKDCIVVKILNKAVKDGWKDRIPLLWILFITFLYLVINENILNDCDFQAAKKDININYIKNIKIADNEDDMFFGLIKINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JP5</accession>
    <name>Q73JP5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973036.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2437"/>
    <dbReference type="EnsemblBacteria" id="AAS12955">
        <property type="protein sequence ID" value="AAS12955"/>
        <property type="gene ID" value="TDE_2437"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2437"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2305"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1502845_0_0_12"/>
    <dbReference type="OMA" id="EGDAGTF"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="31"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="179" mass="19681" checksum="C94F917A2F3308A2" modified="2004-07-05" version="1">MEKKDEILALISRLEIFSDLAGLDSAKGSDIADNQNKIFLEKIFSFLSVKNFTGGEIILDKNDTGKSLFILVKGEVQMLRTTLEGSPFALSNLKAEENVCFGKAALLGEDFHGSSVKALNECTVLELRSQDFLSLCNEMPSQGAKVIYRIARRLAKALQEATKDSLTLYQALLDEVGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JQ0</accession>
    <name>Q73JQ0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973057.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680414.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12976">
        <property type="protein sequence ID" value="AAS12976"/>
        <property type="gene ID" value="TDE_2459"/>
    </dbReference>
    <dbReference type="GeneID" id="44155132"/>
    <dbReference type="KEGG" id="tde:TDE_2459"/>
    <dbReference type="HOGENOM" id="CLU_3012953_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="56" mass="6672" checksum="B9EDBF71EFE07B4F" modified="2004-07-05" version="1">MNILDEHKIGLTKLTDLFELNKRQYNTSAYDEANTRTDFIRAEGLIPRRLRRNEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JW1</accession>
    <name>Q73JW1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973124.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2526"/>
    <dbReference type="EnsemblBacteria" id="AAS13043">
        <property type="protein sequence ID" value="AAS13043"/>
        <property type="gene ID" value="TDE_2526"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2526"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2390"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038047_0_0_12"/>
    <dbReference type="OMA" id="FSPKRYN"/>
    <dbReference type="OrthoDB" id="604119at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="482" mass="55112" checksum="7CF9BE8CE8192C9A" modified="2004-07-05" version="1">MITDRASQGFKVVGKWGNVRIDNSSSSPFIDQYQFLANYVERQKMEPEDSQMREYFWQQISYLAFRAAVVQVAMEDEVVNAGYRVPQFRVNKDLINYYLDENGVYSESKYQNTPETTRVTYRKEIEKYIKDNRYIEDLFGNGSGYGLKTSSKETDFIVDMAKKERSFKYVVFNLSLYPSSEIVKYGKEHSDLFTSYDLSLLSYPTEEEAKKMLASLKSGEVSFEDAVILNATKTLTDDSGKITSNYRTDINRYFPDNEHLKAVLALKPSELSPVVSMQNGMFGIVRCNAEPSLPDFESEALISNIRNYMNRNEKGMLEDYVLQTANKFAEAARTAGFEKAAEDFKETTLTVETSNFFGINYGNASSLPSLPSQGIFAALEKNESFFKKAFALKSGEISEPILAGSEVAVLTLEEEKEVDEYTLDRTKKDYQNQAGAWFPYYHIAAIMRMQGMNYPLPIAHKTFMDYIFTNSKFQDNFGNLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JW8</accession>
    <name>Q73JW8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA-ATPase_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973117.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680484.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2519"/>
    <dbReference type="EnsemblBacteria" id="AAS13036">
        <property type="protein sequence ID" value="AAS13036"/>
        <property type="gene ID" value="TDE_2519"/>
    </dbReference>
    <dbReference type="GeneID" id="2739031"/>
    <dbReference type="KEGG" id="tde:TDE_2519"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2384"/>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021114_0_1_12"/>
    <dbReference type="OMA" id="IILLDEY"/>
    <dbReference type="OrthoDB" id="191489at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018631">
        <property type="entry name" value="AAA-ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012547">
        <property type="entry name" value="PDDEXK_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09820">
        <property type="entry name" value="AAA-ATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08011">
        <property type="entry name" value="PDDEXK_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA-ATPase_like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="536" mass="61773" checksum="EE1FA08615B55F4C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JX1</accession>
    <name>Q73JX1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973114.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13033">
        <property type="protein sequence ID" value="AAS13033"/>
        <property type="gene ID" value="TDE_2516"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2516"/>
    <dbReference type="HOGENOM" id="CLU_3405983_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3207" checksum="AED8229B336034CE" modified="2004-07-05" version="1">MSAAAPLIVKAFAFLFLFVLNFIIGSSCQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K36</accession>
    <name>Q73K36_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973179.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2581"/>
    <dbReference type="EnsemblBacteria" id="AAS13098">
        <property type="protein sequence ID" value="AAS13098"/>
        <property type="gene ID" value="TDE_2581"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2581"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2441"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1085615_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="256" mass="30802" checksum="DD2D60794E05B895" modified="2004-07-05" version="1">MKILNNRYRIIKELPIELKTNTGFVVHDLGSDNREQLELRLIYASDLDEDFMQFIREKFLLIKQLKESVHIKNYDFTRLISIHNKIIDEDIYLYTIEHIEKKIPILDFLPDATTKDIFELFAAILKELNYLLTYGIVYNNFDLTNIYVIKNNGRIFIKAKDLVTEKNQYSDQIGLLSNEEIYTFNYNHDILKTIILSLFLKKNIIKNHEKYFQELQQIETNRLNDENEKHLYKCFFKIYNKINTRKLKKNPTPFMK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K39</accession>
    <name>COBS_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="1">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobS</name>
        <name type="ordered locus">TDE_2383</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972982.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680312.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73K39"/>
    <dbReference type="STRING" id="243275.TDE_2383"/>
    <dbReference type="EnsemblBacteria" id="AAS12901">
        <property type="protein sequence ID" value="AAS12901"/>
        <property type="gene ID" value="TDE_2383"/>
    </dbReference>
    <dbReference type="GeneID" id="2740685"/>
    <dbReference type="KEGG" id="tde:TDE_2383"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2251"/>
    <dbReference type="eggNOG" id="COG0368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057426_1_2_12"/>
    <dbReference type="OMA" id="GHTGDTY"/>
    <dbReference type="OrthoDB" id="1996371at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00317">
        <property type="entry name" value="cobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000148032" description="Adenosylcobinamide-GDP ribazoletransferase">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <sequence length="260" mass="29031" checksum="E09F1480C22BF4A0" modified="2004-07-05" version="1">MKGFILALQFFTRIPININIDFNEKNIKRAFYFLPLIGGLIAGLVLIPIYFLPQKYIEISGFISLLLYLFLTGSIHLDGVGDTIDGFFSARKKEKILEIMQDPRIGTYGTIGLNVFLLLRYINYSTIIPDAGLLILAGIISRLSGLAVVVFSKPAKDTGLGLLFHKSASKFSFFFWLVLVCFLSLFTPEIAAFSKIQGTFILVERLKYLLLPLTAFILTFIIIRISYKKIGGITGDVNGLIVELTELAVLSTSFFINVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K45</accession>
    <name>Q73K45_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972976.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2377"/>
    <dbReference type="EnsemblBacteria" id="AAS12895">
        <property type="protein sequence ID" value="AAS12895"/>
        <property type="gene ID" value="TDE_2377"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2377"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2245"/>
    <dbReference type="HOGENOM" id="CLU_3206550_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="45" mass="5368" checksum="E8CC56A9F1D90E5E" modified="2004-07-05" version="1">MIAPKNRKFLKEFYKVTYKNFSFLEMPINNFSAIGSCIKGFFLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K51</accession>
    <name>Q73K51_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-sulfur cluster-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972970.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2371"/>
    <dbReference type="EnsemblBacteria" id="AAS12889">
        <property type="protein sequence ID" value="AAS12889"/>
        <property type="gene ID" value="TDE_2371"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2371"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2239"/>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033147_1_0_12"/>
    <dbReference type="OMA" id="CPVGAFY"/>
    <dbReference type="OrthoDB" id="1230380at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="277" mass="31049" checksum="F37AC5AAA6086EB7" modified="2004-07-05" version="1">MLAIDGNLIGFLKGQIYKGPMKKVCMPVLNCYSCPGALFGCPIGSIQATIGSSKFNFAFYVVGLLSLFAIAAGRLFCGYICPFGLFQDLLDKIPLKKIKVPQKVNKVLKYLKYFILVFFVFVLPFALQDKYGISDPYFCKYICPSGILFGAIPLISMNRVLTASLGALFGLKFTVLAIITMLSMIFYRPFCRYLCPLGAFLGMFNPISLYRLKINDKCIKCRKCERTCKLDIPTYKTPNSPECIRCGECIKACPVKAIEHSFLFTEKSTNMDLNIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K53</accession>
    <name>Q73K53_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972968.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680292.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2369"/>
    <dbReference type="EnsemblBacteria" id="AAS12887">
        <property type="protein sequence ID" value="AAS12887"/>
        <property type="gene ID" value="TDE_2369"/>
    </dbReference>
    <dbReference type="GeneID" id="2739978"/>
    <dbReference type="KEGG" id="tde:TDE_2369"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2237"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_769330_0_0_12"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285805" evidence="3">
        <location>
            <begin position="24"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="209"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="365" mass="40721" checksum="71A1596D1CAACCC8" modified="2004-07-05" version="1">MKKFYKIFIAAVVFSLVASAAFAGGSKETGIKELTKKEKEAGWRYFKPIGFKLHRPAFFDTYRDNVNADSSVGEEDKKTDEVVYKVYLYEFASDELNEKYDAIVSNKQLSRDQKIEKINKEVNPYLKPIYKLVVLRTPLIGKKTLAELTGLPNNEVIRKTKEFTQVLAIADFNAEGLSEKAAEIYKDMISQVRPIIPTIQCTDPISAEAAMIKNVKGLTFNTVDLEGNKITSDILAKYDVTMINIWATWCPPCRAELPEIAKLYEAFKDKGCNIIGITGDVSPDEQDALPTAKELISKAGCKYTVVQYNDTLKPILDNLAAWPTTIFVDKKGNIIASSVNDIIIGSRDLAEFTEAMKKALKAVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KB0</accession>
    <name>Q73KB0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-54 dependent transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972909.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680223.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2309"/>
    <dbReference type="EnsemblBacteria" id="AAS12828">
        <property type="protein sequence ID" value="AAS12828"/>
        <property type="gene ID" value="TDE_2309"/>
    </dbReference>
    <dbReference type="GeneID" id="2740274"/>
    <dbReference type="KEGG" id="tde:TDE_2309"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2179"/>
    <dbReference type="eggNOG" id="COG3604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_125_2_12"/>
    <dbReference type="OMA" id="RAGRFQM"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="186"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="513" mass="56741" checksum="BB3CA7124AA06A49" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KG5</accession>
    <name>Q73KG5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HicB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972853.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680115.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2253"/>
    <dbReference type="EnsemblBacteria" id="AAS12772">
        <property type="protein sequence ID" value="AAS12772"/>
        <property type="gene ID" value="TDE_2253"/>
    </dbReference>
    <dbReference type="GeneID" id="2741358"/>
    <dbReference type="KEGG" id="tde:TDE_2253"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2127"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114047_0_2_12"/>
    <dbReference type="OMA" id="PRWLNKA"/>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="138" mass="15479" checksum="827DE05BF58F4C0D" modified="2004-07-05" version="1">MKKQERFFYPAIFTYNGKKEIAVVFPDLGCATSGKDEADALLSARELLGCVLCGLEDDGEPIPKASHLSNIKTGKNEKSVLIDVYLPTYRMMQKTRSVNRTVTLPAWLNALASEHNINCSQLLQESLKKQFQTVLQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KG6</accession>
    <name>Q73KG6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972852.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674407.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2252"/>
    <dbReference type="EnsemblBacteria" id="AAS12771">
        <property type="protein sequence ID" value="AAS12771"/>
        <property type="gene ID" value="TDE_2252"/>
    </dbReference>
    <dbReference type="GeneID" id="2741357"/>
    <dbReference type="KEGG" id="tde:TDE_2252"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2126"/>
    <dbReference type="eggNOG" id="COG1724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_4_2_12"/>
    <dbReference type="OMA" id="VVPHPKK"/>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="65" mass="7504" checksum="4FA3B2AC823133BA" modified="2004-07-05" version="1">MKSYTSREVIKILQNDGWYEVAVVGSHHQFKHSIKKGRVTVKHPDKDIPIATLKTIEKQSGIRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KI6</accession>
    <name>Q73KI6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron compound ABC transporter, ATP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2232</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972832.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680085.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2232"/>
    <dbReference type="EnsemblBacteria" id="AAS12751">
        <property type="protein sequence ID" value="AAS12751"/>
        <property type="gene ID" value="TDE_2232"/>
    </dbReference>
    <dbReference type="GeneID" id="2741337"/>
    <dbReference type="KEGG" id="tde:TDE_2232"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2108"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_12"/>
    <dbReference type="OMA" id="RYAWNGL"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="259" mass="29149" checksum="3C8D0C0763A225D7" modified="2004-07-05" version="1">MDYPLINVKSVYAGYSKTPVLKDISFSVLKGDSLCVLGPNGCGKTTLLKTLAGLIGYSGEILLNGQNLKNIKRKDIAKKIAVLSQVSSIYFSYSVYDTVMMGRYAHREGSSFLSVSKKDRAYVEKCLRAVDIWNLREKKIDELSGGQLQRVYLARTLAQEPELILLDEPTNHLDLKAQTELILFLKEICKKEAKAVIGVFHDINLALQFADKLIFLKDGIIQASGKKDEVLNREILQSVYGMDVAEWMKDSFNLWLRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KM1</accession>
    <name>Q73KM1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972797.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957176.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2196"/>
    <dbReference type="EnsemblBacteria" id="AAS12716">
        <property type="protein sequence ID" value="AAS12716"/>
        <property type="gene ID" value="TDE_2196"/>
    </dbReference>
    <dbReference type="GeneID" id="2740218"/>
    <dbReference type="KEGG" id="tde:TDE_2196"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2073"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071023_2_0_12"/>
    <dbReference type="OMA" id="KATNEFT"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="254" mass="29578" checksum="85C1B1DB4425EAA0" modified="2004-07-05" version="1">MVKKFEDLTFTDDFMFCKTMQNPRLCKKLIEMILSDTIGKIAYISIQHNINTYEQAKSVRFDVLVQAENGKLYDVEMQVSNERNIPKRMRFYQAAIDISFLDKGNSYNSLNDSFIIFICTFDAIGKNRSVYTFENLCIEDKNTSLQDGIRKVIINAEAFNNTQDKELKEFLEYLKTGKATNEFTREIETMIQAVKNNEQARQEYRLMSTFEMDAREKGAYDKSIETAKLMKLKNFDIALIKEITGLPESEIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KM9</accession>
    <name>Q73KM9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972789.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680033.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2188"/>
    <dbReference type="EnsemblBacteria" id="AAS12708">
        <property type="protein sequence ID" value="AAS12708"/>
        <property type="gene ID" value="TDE_2188"/>
    </dbReference>
    <dbReference type="GeneID" id="2740210"/>
    <dbReference type="KEGG" id="tde:TDE_2188"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2065"/>
    <dbReference type="eggNOG" id="ENOG5031CKK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040422_0_0_12"/>
    <dbReference type="OrthoDB" id="1326419at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="515" mass="58614" checksum="B62CED072EF6F0ED" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KQ6</accession>
    <name>Q73KQ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972762.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679998.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2161"/>
    <dbReference type="EnsemblBacteria" id="AAS12681">
        <property type="protein sequence ID" value="AAS12681"/>
        <property type="gene ID" value="TDE_2161"/>
    </dbReference>
    <dbReference type="GeneID" id="2739147"/>
    <dbReference type="KEGG" id="tde:TDE_2161"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2041"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_12"/>
    <dbReference type="OMA" id="NIREVRW"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="184" mass="21264" checksum="F629324ED0127CA1" modified="2004-07-05" version="1">MYIKKLIGKKCYLAPMRIEDAEKYTVWANDQEVAEYLNFASSIISLEAERIIIDRISKEHNYAIVDSETDELIGNMGLMSINHINRTAELGIFIGNKAYWSKGYGTEAMCLLINYAYQKLNLHNIILNVYSYNERAVKAYEKVGFKKVGARRGALIRNRKMHDIILMDIIPEDFYAKHPEFELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KU2</accession>
    <name>Q73KU2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucyl/phenylalanyl-tRNA--protein transferase</fullName>
            <ecNumber evidence="4">2.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L/F-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Leucyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Phenyalanyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">aat</name>
        <name evidence="5" type="ordered locus">TDE_2125</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:50416"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12673"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64719"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133044"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N-terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:12340"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="Rhea" id="RHEA-COMP:12670"/>
            <dbReference type="Rhea" id="RHEA-COMP:12671"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:65249"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:133043"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl-tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:43632"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10637"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83561"/>
            <dbReference type="EC" id="2.3.2.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the L/F-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.6" evidence="4"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972726.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679939.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2125"/>
    <dbReference type="EnsemblBacteria" id="AAS12645">
        <property type="protein sequence ID" value="AAS12645"/>
        <property type="gene ID" value="TDE_2125"/>
    </dbReference>
    <dbReference type="GeneID" id="2739384"/>
    <dbReference type="KEGG" id="tde:TDE_2125"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2008"/>
    <dbReference type="eggNOG" id="COG2360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075045_0_0_12"/>
    <dbReference type="OMA" id="YRQGIFP"/>
    <dbReference type="OrthoDB" id="1670846at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008914">
        <property type="term" value="F:leucyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00688">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004616">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042203">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042221">
        <property type="entry name" value="Leu/Phe-tRNA_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30098">
        <property type="entry name" value="PTHR30098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03588">
        <property type="entry name" value="Leu_Phe_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00667">
        <property type="entry name" value="aat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="246" mass="28130" checksum="957A1142D1389BAF" modified="2004-07-05" version="1">MQTGFSSLSLLSSTEKKILLKRSQKDFPWLESEDFFDFNKALGEEDYIQKSQDDEVISGGNLSPGMILSAYKHSFFPWFSEEDPIIWFSPSLRFVIDKASFHIPSRLKREIKKTNFKISRNEAFDEVIENCALIKREGQKGTWITDDMLQAYRLLHKLGFAHSVEAWRGGELAGGFYGLYINEVFIGESMFSEISGASKTAFALFAQDFFENKKGILIDAQIPSENIKRFGGFKIPRNRYLGILNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KV5</accession>
    <name>Q73KV5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC_transp_aux domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972713.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679921.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2112"/>
    <dbReference type="EnsemblBacteria" id="AAS12632">
        <property type="protein sequence ID" value="AAS12632"/>
        <property type="gene ID" value="TDE_2112"/>
    </dbReference>
    <dbReference type="GeneID" id="2740351"/>
    <dbReference type="KEGG" id="tde:TDE_2112"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1995"/>
    <dbReference type="eggNOG" id="COG3225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543946_0_0_12"/>
    <dbReference type="OMA" id="IANFADH"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019196">
        <property type="entry name" value="ABC_transp_unknown"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09822">
        <property type="entry name" value="ABC_transp_aux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="ABC_transp_aux" evidence="2">
        <location>
            <begin position="29"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="495" mass="56777" checksum="9C02032778520AAA" modified="2004-07-05" version="1">MKKEYKFQFFLFVLMLILISLVSSKIYFRLDTTKEKNYTLSNYTKELLTNLESSVKVTWFKSSNVDNFFPSLKYLNDMLSEYKLYSKGDFSVVLKDTASLSSDAINKIGLIPREIEAQDNSVKIIHKLYSGLMIEYMGQTRIIPFIDDIDTLEYDLARFILSMRSDALGDTQAGTVFLIADPALLETDYSYVIPWLEYAGFNVLPLELPVSNIPAEFPLLVIGSDYIDYSSAAAIDMFLQKEGRAVFFVSGNKVDVKGSWKAKPKVKDFLLDVLSHHGFYINADMALDLINNFRITMAQVDNKGTKLINYPFWIQFPLSGINRDHPIFAAYRPLISFWPSSIDLDLNKNTELVPYVLTGQNSLTVFDSYSTDPLENHFKKFEDASFKPSVIVAGQTKPSRILVIGDEYMISRAIDYTGSTYNMDFMVNCVEYVSLKDNLLLLKNKKHSPPPFKQFEDREKMTNLVFRARLISIILLPLSVFILGLYMFIKQRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KV8</accession>
    <name>Q73KV8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase, DEAD/DEAH box family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_2109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972710.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957152.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2109"/>
    <dbReference type="EnsemblBacteria" id="AAS12629">
        <property type="protein sequence ID" value="AAS12629"/>
        <property type="gene ID" value="TDE_2109"/>
    </dbReference>
    <dbReference type="GeneID" id="2740348"/>
    <dbReference type="KEGG" id="tde:TDE_2109"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1992"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_21_1_12"/>
    <dbReference type="OMA" id="FGCQALV"/>
    <dbReference type="OrthoDB" id="626183at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
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    </dbReference>
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        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
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    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
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        <location>
            <begin position="35"/>
            <end position="205"/>
        </location>
    </feature>
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        <location>
            <begin position="232"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="526"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS12629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="570" mass="63673" checksum="BCF32FF2643EE870" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KW7</accession>
    <name>Q73KW7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="TDE_2100"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.1983"/>
    <dbReference type="HOGENOM" id="CLU_3298100_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="40" mass="4476" checksum="48FDC6DDDF52E2BC" modified="2004-07-05" version="1">MKNVQDVHSSTGTDAGGSMLTSFLRSKNTRSLKMYKDVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KX5</accession>
    <name>Q73KX5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amino acid ABC transporter, amino acid-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972693.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679895.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2092"/>
    <dbReference type="EnsemblBacteria" id="AAS12612">
        <property type="protein sequence ID" value="AAS12612"/>
        <property type="gene ID" value="TDE_2092"/>
    </dbReference>
    <dbReference type="GeneID" id="2740331"/>
    <dbReference type="KEGG" id="tde:TDE_2092"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1976"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_4_12"/>
    <dbReference type="OMA" id="WFGIDVS"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="49"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="279" mass="31989" checksum="D90E7889F220D04C" modified="2004-07-05" version="1">MKKNPNHIFKLSFLFLFTVLVMISCKPKAVRIQKKENDISLAKILVKKELIIGIRDDHPPFSVLNLFTTKMEGYDIEVAQELCNRMKIKPIFKVIKWNQRESLLKDGEIDCIWSAFVYSKESDVVYSLTSPYIKSAIILVVKDKSPYYSIQDIREKKIGITSSSFIQESLKKAESSLGVFTNTVVFQNAQEAINALEKDEVECVVYDLLSINNLIQTRKGSYRVLDEAIAYEEYVIAFRKEDIALKNAVESTLEEMAKTDFLEKTSKKWFGANISIIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L02</accession>
    <name>Q73L02_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferrous iron transport protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">feoA</name>
        <name evidence="3" type="ordered locus">TDE_2064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972666.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668304.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2064"/>
    <dbReference type="EnsemblBacteria" id="AAS12577">
        <property type="protein sequence ID" value="AAS12577"/>
        <property type="gene ID" value="TDE_2064"/>
    </dbReference>
    <dbReference type="GeneID" id="2741191"/>
    <dbReference type="KEGG" id="tde:TDE_2064"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1948"/>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150646_12_4_12"/>
    <dbReference type="OMA" id="DPMAFSI"/>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="74" mass="8068" checksum="43343C822684B34D" modified="2004-07-05" version="1">MTLDELEQGKKGIIEDLEISGMTLQRLISLGFTPGAELSVVRKAPLLDPFDISICGSLVAVRKDEAKKIIVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L61</accession>
    <name>Q73L61_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2004"/>
    <dbReference type="EnsemblBacteria" id="AAS12518">
        <property type="protein sequence ID" value="AAS12518"/>
        <property type="gene ID" value="TDE_2004"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2004"/>
    <dbReference type="HOGENOM" id="CLU_3174427_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="47" mass="5512" checksum="1186E2DBCC01FA3D" modified="2004-07-05" version="1">MNAVYAPFDNFQTDAYNINDGRINKKEKRYLYGNSQKCKSGVFAKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L92</accession>
    <name>Q73L92_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CvpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1973</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AAS12487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679705.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1973"/>
    <dbReference type="EnsemblBacteria" id="AAS12487">
        <property type="protein sequence ID" value="AAS12487"/>
        <property type="gene ID" value="TDE_1973"/>
    </dbReference>
    <dbReference type="GeneID" id="2741536"/>
    <dbReference type="KEGG" id="tde:TDE_1973"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1865"/>
    <dbReference type="eggNOG" id="COG1286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129914_0_0_12"/>
    <dbReference type="OMA" id="FFLVIHI"/>
    <dbReference type="OrthoDB" id="2061122at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="155" mass="17024" checksum="8D8CC49552B2BC76" modified="2004-07-05" version="1">MRIGSADIVFLIILSFFVIKVTVTGFIDEFFSKAAVIVGGLVAFLFYKLLTPVITELLGGKSLSAVIAFLILFLSTYLIIKLVQVFLGSLFSSESLKNLDRSLGFCLGLVEGLIVIGVILMLINIQTFVSFDKILSESIFAKILSPFILDITKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LA1</accession>
    <name>Q73LA1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na/Pi cotransporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_1964</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972567.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669793.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12478">
        <property type="protein sequence ID" value="AAS12478"/>
        <property type="gene ID" value="TDE_1964"/>
    </dbReference>
    <dbReference type="GeneID" id="2741527"/>
    <dbReference type="KEGG" id="tde:TDE_1964"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1856"/>
    <dbReference type="eggNOG" id="COG1283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025623_0_1_12"/>
    <dbReference type="OMA" id="FCAVAYN"/>
    <dbReference type="OrthoDB" id="1341748at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004633">
        <property type="entry name" value="NaPi_cotrn-rel/YqeW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00704">
        <property type="entry name" value="NaPi_cotrn_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="8">
        <location>
            <begin position="351"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="549" mass="60513" checksum="FDDB41D1CB7A36E1" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LA5</accession>
    <name>Q73LA5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972563.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679683.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1960"/>
    <dbReference type="EnsemblBacteria" id="AAS12474">
        <property type="protein sequence ID" value="AAS12474"/>
        <property type="gene ID" value="TDE_1960"/>
    </dbReference>
    <dbReference type="GeneID" id="2741523"/>
    <dbReference type="KEGG" id="tde:TDE_1960"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1852"/>
    <dbReference type="eggNOG" id="COG4226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173195_1_1_12"/>
    <dbReference type="OMA" id="KIEPPDY"/>
    <dbReference type="OrthoDB" id="1944332at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="63" mass="7237" checksum="88F1185EF8CEC868" modified="2004-07-05" version="1">MVKEVSKFDNISINQFITAAIGEKLTALQTENYLEKRSKKGSKEKFLSVLDKAPDIRPEEYDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LC3</accession>
    <name>Q73LC3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972545.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1942"/>
    <dbReference type="EnsemblBacteria" id="AAS12456">
        <property type="protein sequence ID" value="AAS12456"/>
        <property type="gene ID" value="TDE_1942"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1942"/>
    <dbReference type="HOGENOM" id="CLU_3384324_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="33" mass="3837" checksum="65E1517C44D43EC1" modified="2004-07-05" version="1">MFTIIELKKQKIKHGENNKKTAHPLNEPFCARA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LG9</accession>
    <name>ERA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">era</name>
        <name type="ordered locus">TDE_1895</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972498.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679589.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73LG9"/>
    <dbReference type="SMR" id="Q73LG9"/>
    <dbReference type="STRING" id="243275.TDE_1895"/>
    <dbReference type="EnsemblBacteria" id="AAS12409">
        <property type="protein sequence ID" value="AAS12409"/>
        <property type="gene ID" value="TDE_1895"/>
    </dbReference>
    <dbReference type="GeneID" id="2739124"/>
    <dbReference type="KEGG" id="tde:TDE_1895"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1794"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038009_1_0_12"/>
    <dbReference type="OMA" id="WAEVDVI"/>
    <dbReference type="OrthoDB" id="984717at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000079764" description="GTPase Era">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Era-type G" evidence="2">
        <location>
            <begin position="2"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="202"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="2">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="2">
        <location>
            <begin position="36"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="2">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="2">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="2">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <sequence length="294" mass="33180" checksum="F5E997999606CAC3" modified="2004-07-05" version="1">MNSGVVTIIGRPSAGKSTFLNTASGEKVSIVSAIPQTTRNAIRGIVNTTKGQIVFIDTPGYHKSEKKLNLKLQEIAKTRLEEGDAVLYLIDLSREFGEEEKNICSLLIPLQNKTVIGLNKADLKSSKADLVKKELLSLLPDIPQERIFEISALKDEGINEILSLLIELLPEGEALYPEDIYTDQDVVFRITEIIREQAILHTREEIPHALYAGVEDAEMHKNGKELWVRAFLYVEKESQKAMLIGKGAAVIKSIRIKSMAELRKIFPYKVQLDLQVRVNKNWRQKDNIIKKISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LH2</accession>
    <name>Q73LH2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972494.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679585.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1891"/>
    <dbReference type="EnsemblBacteria" id="AAS12405">
        <property type="protein sequence ID" value="AAS12405"/>
        <property type="gene ID" value="TDE_1891"/>
    </dbReference>
    <dbReference type="GeneID" id="2739120"/>
    <dbReference type="KEGG" id="tde:TDE_1891"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1791"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071023_2_0_12"/>
    <dbReference type="OMA" id="WKIEREV"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="254" mass="29766" checksum="59DFCE1D5EA39FC9" modified="2004-07-05" version="1">MLKKFEDLTLQDDFMFCKVMQNPDLCKRLIEMILADTIGKIAYISVQHNINTYEQAKSVRFDVLVQTENGKFYDVGMQVSNEKNILKRMRFYQAAIDISFLDKGNFYSDLNDSFVIFICLFDVIGKNRPVYTFENICLEDKNTSLQDGTKKVIINSEAFKDAKDKELKEFLEYLKTGKAKSEFTRRIEEMIQTVKQNEQARQEYRLMSTFEMDARYKGIYENKRETAKILKQLGDSLQKIMQVTGLTESEIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LJ6</accession>
    <name>Q73LJ6_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1866"/>
    <dbReference type="EnsemblBacteria" id="AAS12381">
        <property type="protein sequence ID" value="AAS12381"/>
        <property type="gene ID" value="TDE_1866"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1866"/>
    <dbReference type="HOGENOM" id="CLU_3399005_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="31" mass="3888" checksum="A7AB13D589E3FC35" modified="2004-07-05" version="1">MKKEKLLTAIRLQHRAEIRGYFTIFFLFFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LL4</accession>
    <name>Q73LL4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972452.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679545.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1848"/>
    <dbReference type="EnsemblBacteria" id="AAS12363">
        <property type="protein sequence ID" value="AAS12363"/>
        <property type="gene ID" value="TDE_1848"/>
    </dbReference>
    <dbReference type="GeneID" id="2740037"/>
    <dbReference type="KEGG" id="tde:TDE_1848"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1753"/>
    <dbReference type="eggNOG" id="ENOG5032X2Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036894_0_0_12"/>
    <dbReference type="OMA" id="IFAMGNI"/>
    <dbReference type="OrthoDB" id="892293at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285961" evidence="1">
        <location>
            <begin position="20"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="485" mass="53827" checksum="E186EA6C2AC2F068" modified="2004-07-05" version="1">MKKIAIFIFVLFIPFFVFAQENSSDLENDLFGGDEDTLISAEEARSDSKSNLKFKADLEKASLSLESKKLRIGGSLSSSMGINYAWVDPYSKKDDYLKSFKDGKGSFNTTLNGSLFFDARPNEDLKLYGKFLFGFPFEKSLSGQGAAFVPKSIVPPNGLKLPAFVEVSGVPNIKIQELYTDFSAKDIAFFRFGKHAVKWGTGYFYSPADVINISRIDPQDPTADREGGISLRTHIIIPKTQHNIWLYLLPPEQRDGYDPKYTAGAAKGEFVVGNWELGFGGWYKYEKAPRLITTVSGSIAGKVAVFGEGVFAWGSDYTYYKADMSPYTEKNKPFFQATLGGSYSNADTNTGIVLQYFYNGFGYSNTDVPQDILSKAAVHIKNKNYTHPSVLASGDIFAMGNIGQHYIALNISQNKLGTDKLSLNFFQQFAISELEGFSKLTLNWRIYKFASMSTGPSFSYPLSPNSKTKGEVRYSLSFRLGGGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LN2</accession>
    <name>Q73LN2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972434.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12345">
        <property type="protein sequence ID" value="AAS12345"/>
        <property type="gene ID" value="TDE_1830"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1830"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1736"/>
    <dbReference type="HOGENOM" id="CLU_3298096_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="40" mass="4687" checksum="36DCCB0041E5B1D6" modified="2004-07-05" version="1">MILFHFTPIKAIFILIEIAALINTTTVIYTKKIRFFSKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LU9</accession>
    <name>Q73LU9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972367.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679507.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1763"/>
    <dbReference type="EnsemblBacteria" id="AAS12278">
        <property type="protein sequence ID" value="AAS12278"/>
        <property type="gene ID" value="TDE_1763"/>
    </dbReference>
    <dbReference type="GeneID" id="2740608"/>
    <dbReference type="KEGG" id="tde:TDE_1763"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1685"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2182790_0_0_12"/>
    <dbReference type="OrthoDB" id="425785at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="109" mass="12352" checksum="34292F38E22058BD" modified="2004-07-05" version="1">MSKRIEILRSFYDDIDEDSRLNRSRQGQLEYITTMNYIHRYAKTGAKILEIGAGTGRYSIALAKEGYNVTAVELVETNLEVLKNNSVGIENIISYQGDALNEAIYILPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M11</accession>
    <name>Q73M11_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972304.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1700"/>
    <dbReference type="EnsemblBacteria" id="AAS12215">
        <property type="protein sequence ID" value="AAS12215"/>
        <property type="gene ID" value="TDE_1700"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1700"/>
    <dbReference type="HOGENOM" id="CLU_3367951_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="35" mass="4333" checksum="65888060433E819A" modified="2004-07-05" version="1">MISKSFHIFYAWKKYFLQGEFYGKRKKFISLIRNG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M39</accession>
    <name>TIG_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trigger factor</fullName>
            <shortName evidence="1">TF</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tig</name>
        <name type="ordered locus">TDE_1671</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972276.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679366.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M39"/>
    <dbReference type="SMR" id="Q73M39"/>
    <dbReference type="STRING" id="243275.TDE_1671"/>
    <dbReference type="PRIDE" id="Q73M39"/>
    <dbReference type="EnsemblBacteria" id="AAS12187">
        <property type="protein sequence ID" value="AAS12187"/>
        <property type="gene ID" value="TDE_1671"/>
    </dbReference>
    <dbReference type="GeneID" id="2739012"/>
    <dbReference type="KEGG" id="tde:TDE_1671"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1597"/>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033058_3_1_12"/>
    <dbReference type="OMA" id="KGIKTQF"/>
    <dbReference type="OrthoDB" id="932993at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000179454" description="Trigger factor">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="1">
        <location>
            <begin position="170"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <sequence length="451" mass="52111" checksum="FA338FD48F7F5F73" modified="2004-07-05" version="1">MDYEKNVTLKEKSHAELSVKIKKSDVQESYKKLLNKYSKELQIPGFRKGKVPVSVLETKYGDAIKGDLAGDLIEESLKEIFESLDEYERPLPYSYPELNEKPELKVEEDFSFTVHYDVFPKVEIKKTEGFTIEVPEASVSEKDIKKELERLQERNALVTACKEGTSAEKDHIATIDYCELDDEGKTISGTERKDFVFTIGSGLNIYKIDDDIVGMKKGESKEITKTFPEDDSNKDLAGKTKKIKVTLTALKYKDLPALDDDFAQDINEKYKNLDELKADIKKKFEISVEEKIKSLQKNALTEQMVKEHTIDLPESMVRAELESRWMMMANQFRTTPEELEKMFGKGPQSKAALLEGWREDSEKTLKERVLIETLLKEKNIEVSDDEIEAEYVRLSERMDIALDELKKYYSNPREKEYLSEGLKEEKLFKALYEKSTIKKGKKLTFDELLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M66</accession>
    <name>Q73M66_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PASTA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972249.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678383.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1643"/>
    <dbReference type="EnsemblBacteria" id="AAS12160">
        <property type="protein sequence ID" value="AAS12160"/>
        <property type="gene ID" value="TDE_1643"/>
    </dbReference>
    <dbReference type="GeneID" id="2739752"/>
    <dbReference type="KEGG" id="tde:TDE_1643"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1571"/>
    <dbReference type="eggNOG" id="COG2815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066816_0_0_12"/>
    <dbReference type="OMA" id="LIPHIEF"/>
    <dbReference type="OrthoDB" id="723521at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="2">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="330" mass="36019" checksum="BFDFEFB56ACE2D25" modified="2004-07-05" version="1">MGLGDIADSIESNGKVIVITSLVMLVFFIIVSTIVFFMSVKTADQVLVPNIEGEKFEDAVLKLQVKELYPRLQLRFSDNTEDAGTVLEQSPPAGTIVKAGKRITVTVSSGAVLDRVENYVGKTLSEVQQHFASLFTSGRKQLISIKEPIMYKSSSIPAGTILEQNPAPDTKISEGVFIEFIVSKGPENEKVSVPNMEGLKLDDIYSAIAQSKISFVIKAEVNSSLDAPVVVSQSQPADSSIDAYSQIELGMQFPDSTEKMVYGVYSPALPRYPYPVKVTVDAVYPDGKRKELISFNHQGGKCSIPYGLPQGTVLVLTVLNKQVQMFEVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M73</accession>
    <name>Q73M73_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Surface antigen, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972242.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679320.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1636"/>
    <dbReference type="EnsemblBacteria" id="AAS12153">
        <property type="protein sequence ID" value="AAS12153"/>
        <property type="gene ID" value="TDE_1636"/>
    </dbReference>
    <dbReference type="GeneID" id="2739745"/>
    <dbReference type="KEGG" id="tde:TDE_1636"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1564"/>
    <dbReference type="eggNOG" id="ENOG5031BZG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007801_1_0_12"/>
    <dbReference type="OrthoDB" id="1009714at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285836" evidence="1">
        <location>
            <begin position="23"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="812" mass="89463" checksum="AF91AE6967BC4F62" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M82</accession>
    <name>Q73M82_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminomethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gcvT</name>
        <name evidence="9" type="ordered locus">TDE_1627</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972233.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002683018.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1627"/>
    <dbReference type="EnsemblBacteria" id="AAS12144">
        <property type="protein sequence ID" value="AAS12144"/>
        <property type="gene ID" value="TDE_1627"/>
    </dbReference>
    <dbReference type="GeneID" id="2739736"/>
    <dbReference type="KEGG" id="tde:TDE_1627"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1555"/>
    <dbReference type="eggNOG" id="COG0404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_10_2_12"/>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="OrthoDB" id="282830at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="7">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="8">
        <location>
            <begin position="281"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="357" mass="40004" checksum="8D7BFD0D94650F84" modified="2004-07-05" version="1">MKRTPYYETLLAKGGKFVEFGGYEMPIQFAGILKEHLAVRNNVGLFDVSHMGEFYIEGDNAEAAVNALITNDIRGMADGDVRYTLMCNEKGGIVDDFLVYRYNQKKFLLVVNAGNHDKDYDWVKKHLDKSVTFTDRSSEIAQLAIQGPNAPAVVKKFIAPSAMPSAYYTFKTFQCPKGEVIVSQTGYTGEDGYEIYCPKEWALELFNQVMKAGEEFGIELCGLGCRDTLRLEAGMPLYGHEMTEETLATEVTLKPFIKLEKEDFIGKKALETNEAKKIRKGFKMIDRGIARDHDKVFLGDKEIGYVTTGTSSPSLKVGIGHMRIDRGIKDEEVLIEVRGKKLKAKIVPTSFLKEIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M90</accession>
    <name>Q73M90_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972225.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957009.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1619"/>
    <dbReference type="EnsemblBacteria" id="AAS12136">
        <property type="protein sequence ID" value="AAS12136"/>
        <property type="gene ID" value="TDE_1619"/>
    </dbReference>
    <dbReference type="GeneID" id="2740860"/>
    <dbReference type="KEGG" id="tde:TDE_1619"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131458_1_0_12"/>
    <dbReference type="OMA" id="CTAITSK"/>
    <dbReference type="OrthoDB" id="1496712at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="129" mass="15126" checksum="0D05DF8E435A8FF2" modified="2004-07-05" version="1">MDNKLKHLEFIQNVIERMNNNSIQLKTWTILLAVGVLALAGKQESWFIMLCAMMPTGLFWLLNIHFLKIERSYRVLYDTVRKKNEKDIDFSMDISNIIVPKKTMPTISCFYLPIMAALLIISGWLYFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MB7</accession>
    <name>Q73MB7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972198.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669145.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1592"/>
    <dbReference type="EnsemblBacteria" id="AAS12109">
        <property type="protein sequence ID" value="AAS12109"/>
        <property type="gene ID" value="TDE_1592"/>
    </dbReference>
    <dbReference type="GeneID" id="2739789"/>
    <dbReference type="KEGG" id="tde:TDE_1592"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1522"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_12"/>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="320"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="550" mass="63044" checksum="E2A8FD5D89E33CCE" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ME7</accession>
    <name>Q73ME7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972167.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1561"/>
    <dbReference type="EnsemblBacteria" id="AAS12078">
        <property type="protein sequence ID" value="AAS12078"/>
        <property type="gene ID" value="TDE_1561"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1561"/>
    <dbReference type="eggNOG" id="ENOG5032NTB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2208883_0_0_12"/>
    <dbReference type="OrthoDB" id="1997454at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="107" mass="12432" checksum="0C1E1433F6C8A773" modified="2004-07-05" version="1">MTIFFRVLGILYILGCLVLFFYCFVFTGLSNHSSYNITCYIICYGLLGFILGLILIFFSSERKISILLFAIIILIFAGVSNVFNIMISYDEWLRRGMPEKYTFLFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MH7</accession>
    <name>Q73MH7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972137.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679181.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1531"/>
    <dbReference type="EnsemblBacteria" id="AAS12048">
        <property type="protein sequence ID" value="AAS12048"/>
        <property type="gene ID" value="TDE_1531"/>
    </dbReference>
    <dbReference type="GeneID" id="2740893"/>
    <dbReference type="KEGG" id="tde:TDE_1531"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1468"/>
    <dbReference type="HOGENOM" id="CLU_1414620_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="192" mass="22582" checksum="ABA095873D472961" modified="2004-07-05" version="1">MMDWNIPEKPSKFYSLQKRKEKLNNAFIWTEENKQKILDLNNHLCSLMDSLYDQVAKLKEIHDRFISEGKTEYSNYSIKGSILYAPDNENPALTKREIKMQEALDSFLKWELYQIFATGIPDCTGSTKMPNREYMDSDKKEYGCIDDIDDFQICKPLSIFLDTVSCFAIEDVLKITPKDFYTEAEVFLEYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MN7</accession>
    <name>Q73MN7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972077.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668947.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1471"/>
    <dbReference type="EnsemblBacteria" id="AAS11988">
        <property type="protein sequence ID" value="AAS11988"/>
        <property type="gene ID" value="TDE_1471"/>
    </dbReference>
    <dbReference type="GeneID" id="2741586"/>
    <dbReference type="KEGG" id="tde:TDE_1471"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1412"/>
    <dbReference type="eggNOG" id="ENOG5033BU4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1383650_0_0_12"/>
    <dbReference type="OMA" id="QMEINIE"/>
    <dbReference type="OrthoDB" id="1289611at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="200" mass="22479" checksum="8CD88F64383B442A" modified="2004-07-05" version="1">MKVKLNGQEIKLKLEQEITIGDVLGNIEQECRNHKSTITQVLVNGNELTLNELDELFQDSHQMEINIELFTTSGEDIRTLLKGLGDEFIKNSEEIEKIPIKVQTGNDVEIIKTIETFSINLAKLYETAKLFDIAEINEDLKLGEMTLCEYQREISSNLDAIINAIEDTDTVEISDIAEYELAPLVKKLGNGLLSINNPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MR2</accession>
    <name>Q73MR2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972052.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679084.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1446"/>
    <dbReference type="EnsemblBacteria" id="AAS11963">
        <property type="protein sequence ID" value="AAS11963"/>
        <property type="gene ID" value="TDE_1446"/>
    </dbReference>
    <dbReference type="GeneID" id="2741409"/>
    <dbReference type="KEGG" id="tde:TDE_1446"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1387"/>
    <dbReference type="eggNOG" id="ENOG5030VAP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1314917_0_0_12"/>
    <dbReference type="OMA" id="FFLISWS"/>
    <dbReference type="OrthoDB" id="2160175at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="209" mass="23638" checksum="0F977E6E37D43BAC" modified="2004-07-05" version="1">MNFVFILVLPLVFLLYASFSKEQGGKFAAFLFGILGGIVSLIIVSFFPFSSLQISSYLSSHLCRFFFQYFFLNALFGLAFFFLISWSLSEETLSNSLSALFGIFSAVFAYLFYRNINTPDSTELSLFLLIITGTILIFDFVYYVLSANLTISMDFMVYAIAFISFIIFSLLGSYALASWYLSKSLNMHTFVSCGMFLVGVVLNIVRNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MS7</accession>
    <name>Q73MS7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-1,4-galactosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972036.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1430"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11947">
        <property type="protein sequence ID" value="AAS11947"/>
        <property type="gene ID" value="TDE_1430"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1430"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1371"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_1_12"/>
    <dbReference type="OMA" id="DSHITFA"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="333" mass="39233" checksum="8E903FB4C3B02069" modified="2004-07-05" version="1">MYDYLFSICIPVYNTEQYLPRALDSIVNQTFDTKKIETVIVNDGSPCSEECDQIIAEYSSRLSIQYIVKNINEGLFLARKTAVEKAAGKYILFLDADDSLEVHSLRILSDSLIDEPDYVQFRIYNVLGCEKSLYHSVLEDETHKTLADVLQNKAIHNLVNKCYNAQLLKRIYDTISNSYAVYAEDYYQSVIIEYFSNKKKFIDIPLYNYFRYIGITSNNTFSNREKLIRIIESFQNIEKNLVSFFEKNNEQQYVQYVKDYIRELYINFAYWTNSLHSIMFVIRQLPNEYHAIRLTIFKRFLMHNIKQLIKNILPYGFVCLIVARKNKVCISSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MW6</accession>
    <name>Q73MW6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971996.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678974.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1390"/>
    <dbReference type="EnsemblBacteria" id="AAS11907">
        <property type="protein sequence ID" value="AAS11907"/>
        <property type="gene ID" value="TDE_1390"/>
    </dbReference>
    <dbReference type="GeneID" id="2741257"/>
    <dbReference type="KEGG" id="tde:TDE_1390"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1332"/>
    <dbReference type="eggNOG" id="COG4656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010808_6_0_12"/>
    <dbReference type="OMA" id="HGCGCCE"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026902">
        <property type="entry name" value="RnfC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13375">
        <property type="entry name" value="RnfC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="428" mass="47315" checksum="D527C7B04F051197" modified="2004-07-05" version="1">MTEFLRFKRGKEVLEYPKLPASFEGNAFLPQKAFIPIAFDSKKRPETLVMKGETVKEGQIIARTEEPFSVGIYSSIPGILYDFIDFTLPDGKHIHAAAVKLEGAFDILGRPSADYPWRTSSNSEIVRAIGYSGILNTADFSTVPLIYQVRNALKKEEADIYINLFDKDPSSGIDSILFDHFFEDVAEGLGIMAKILNAASVTCIHKLAKKDLYKLEQISQTCEPFCKVKFINASNDYPFVQKNYFANKENSLLIDIPTAMYTYEVVRTNNPITSVYVLVTGKAINEPKVLKVKIGTPIGNLIEECGGFKTVPAQIILNGLIGGISADTLDIPVTSTLKSIHIPGKDSIKKHSIEECINCGLCFNSCPLYLEPKKIVESIEAEDLNEDILKQIKICSGCACCSSCCPSRIPLCSIILEMSKKIKKGNLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MY7</accession>
    <name>UVRB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein B</fullName>
            <shortName evidence="1">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrB</name>
        <name type="ordered locus">TDE_1369</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971975.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678935.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MY7"/>
    <dbReference type="SMR" id="Q73MY7"/>
    <dbReference type="STRING" id="243275.TDE_1369"/>
    <dbReference type="EnsemblBacteria" id="AAS11886">
        <property type="protein sequence ID" value="AAS11886"/>
        <property type="gene ID" value="TDE_1369"/>
    </dbReference>
    <dbReference type="GeneID" id="2741130"/>
    <dbReference type="KEGG" id="tde:TDE_1369"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1315"/>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_12"/>
    <dbReference type="OMA" id="EYVDRMV"/>
    <dbReference type="OrthoDB" id="95696at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000227379" description="UvrABC system protein B">
        <location>
            <begin position="1"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="25"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="428"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="625"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <sequence length="662" mass="75802" checksum="3DC4BA462B677A30" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N19</accession>
    <name>Q73N19_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1337</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971943.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678891.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1337"/>
    <dbReference type="EnsemblBacteria" id="AAS11854">
        <property type="protein sequence ID" value="AAS11854"/>
        <property type="gene ID" value="TDE_1337"/>
    </dbReference>
    <dbReference type="GeneID" id="2741071"/>
    <dbReference type="KEGG" id="tde:TDE_1337"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1285"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068418_0_0_12"/>
    <dbReference type="OMA" id="GYMRRET"/>
    <dbReference type="OrthoDB" id="834480at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021243">
        <property type="entry name" value="DUF2804"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35868">
        <property type="entry name" value="PTHR35868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10974">
        <property type="entry name" value="DUF2804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="346" mass="39837" checksum="9A113C4E6A8E3408" modified="2004-07-05" version="1">MNHEVKEKQDLLNAQGHITEEGWARFPVWNYDRSKIKASAFKIKEWDYYSITNSKELWSLNTTMADLGFGALFSVSFIDLKKKAFSQEDAMTFFTFGKTGLKPSSLMDHKLEFKNKKMKLLFCKQGEKIIIQTDVPHMHLPCGKTGLKADIELTRNPNDESMNIATSWKENRKCFYLNEKVNCMPVSGTVSLGNDKITLEKNSSWAVLDWGRGFWTRKNRWYWSSGSGIVEGKRFGFNLGYGFTDRSPASENVIFYDGKIHKLTDVEFHIKNDEYLKPWNFISSDKRFEAEFIPAIDRSANTNLGLIKSVQHQVFGFFSGQAVLDEGKIVKFENFPAFAEDVLNVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N25</accession>
    <name>Q73N25_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Anaerobic ribonucleoside-triphosphate reductase</fullName>
            <ecNumber evidence="5">1.17.4.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nrdD</name>
        <name evidence="5" type="ordered locus">TDE_1331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.17.4.2" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971937.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678883.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1331"/>
    <dbReference type="EnsemblBacteria" id="AAS11848">
        <property type="protein sequence ID" value="AAS11848"/>
        <property type="gene ID" value="TDE_1331"/>
    </dbReference>
    <dbReference type="GeneID" id="2741065"/>
    <dbReference type="KEGG" id="tde:TDE_1331"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1279"/>
    <dbReference type="eggNOG" id="COG1328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002707_0_2_12"/>
    <dbReference type="OMA" id="TNAGHIT"/>
    <dbReference type="OrthoDB" id="195920at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01675">
        <property type="entry name" value="RNR_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="4">
        <location>
            <begin position="30"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="708" mass="80153" checksum="D9A2F9BD942E9B28" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N45</accession>
    <name>Q73N45_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_1311</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678844.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1311"/>
    <dbReference type="EnsemblBacteria" id="AAS11828">
        <property type="protein sequence ID" value="AAS11828"/>
        <property type="gene ID" value="TDE_1311"/>
    </dbReference>
    <dbReference type="GeneID" id="2739569"/>
    <dbReference type="KEGG" id="tde:TDE_1311"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1260"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038267_0_0_12"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="15"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="326"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="358"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="534" mass="60499" checksum="4CB64DD4C9215263" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N56</accession>
    <name>Q73N56_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971906.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668611.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1300"/>
    <dbReference type="EnsemblBacteria" id="AAS11817">
        <property type="protein sequence ID" value="AAS11817"/>
        <property type="gene ID" value="TDE_1300"/>
    </dbReference>
    <dbReference type="GeneID" id="2741054"/>
    <dbReference type="KEGG" id="tde:TDE_1300"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1250"/>
    <dbReference type="eggNOG" id="ENOG5032X70">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089660_0_0_12"/>
    <dbReference type="OMA" id="CYGENSK"/>
    <dbReference type="OrthoDB" id="1286839at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="269" mass="31817" checksum="5FA4D11AB34A3CC4" modified="2004-07-05" version="1">MDGEKSGNRELYTKRVYEYDQVINQVLKHEENILSLIKKDTFGAAYKRLVLADEMIYLATLYLAKFRLSVALLGGKNENILNEARKTLYKPIIYLEEIVTDLIDAPFSEYEEGVDRISKITEKQRYYLIRKLGLVINLVIDAYGENTKWRWSFIDIEARFAVVAKNIMDLKEISQTGLNPHAEDYDTVIYHLRLVKKLFTKAADKYREKYEIVTNNISDFRTAILFLEGLRRVHMVLNEHREVEEIKRKIEIWKDKMEKDLKQKDKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ND7</accession>
    <name>Q73ND7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellum-specific ATP synthase</fullName>
            <ecNumber evidence="4">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fliI</name>
        <name evidence="12" type="ordered locus">TDE_1218</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="4"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971825.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678707.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1218"/>
    <dbReference type="EnsemblBacteria" id="AAS11736">
        <property type="protein sequence ID" value="AAS11736"/>
        <property type="gene ID" value="TDE_1218"/>
    </dbReference>
    <dbReference type="GeneID" id="2740112"/>
    <dbReference type="KEGG" id="tde:TDE_1218"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1173"/>
    <dbReference type="eggNOG" id="COG1157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_5_1_12"/>
    <dbReference type="OMA" id="MLMMDSV"/>
    <dbReference type="OrthoDB" id="875807at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005714">
        <property type="entry name" value="ATPase_T3SS_FliI/YscN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022426">
        <property type="entry name" value="FliI_clade3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040627">
        <property type="entry name" value="T3SS_ATPase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18269">
        <property type="entry name" value="T3SS_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03498">
        <property type="entry name" value="FliI_clade3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01026">
        <property type="entry name" value="fliI_yscN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="10" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="158"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS11736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="474" mass="51141" checksum="AA14E63C273A62DD" modified="2004-07-05" version="1">MVDLFDKYTNAVSETDPIKFTGRVVRVHDKLIESEGPVASVGELCQIITDDNPDGLKAEVVGLNGTIVQLMSYTDVQGVKIGDLVIASGEILSVPVGNILLGRVVDALCKSADGKPEPYSAKRYPVVASPPDAMTRKPIRQRIVTGIRAIDSLLAVGRGQRLGIFAGTGIGKSTLLGMIARNTNADVNVIALIGERGREVLDFIEHDLGPEGLKHSVIVSATSDQSALARIRGAYTATAIAEYFRDQGKDVMLLFDSVTRFAMAQREIGLAIGEPPATRGYTPSVFSSLPKLLERSGTSEKGSITGFYTVLVEGDDMNEPISDAVRGILDGHIVLDRNLAERGQYPAVNVLKSISRLSNRVSGPNTKDASKRMRTLLKDYTESEDMINLGAYQKGSSAAIDDAIDHYPRIYDFLTQEVDDPAKLKDTLQKLSDITGIDIPPEEFDEAGLGVGAIKKYAQSSEASALYKPDREVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NE7</accession>
    <name>Q73NE7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971813.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678696.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1206"/>
    <dbReference type="EnsemblBacteria" id="AAS11724">
        <property type="protein sequence ID" value="AAS11724"/>
        <property type="gene ID" value="TDE_1206"/>
    </dbReference>
    <dbReference type="GeneID" id="2740100"/>
    <dbReference type="KEGG" id="tde:TDE_1206"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1161"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075574_0_0_12"/>
    <dbReference type="OMA" id="FALSTMY"/>
    <dbReference type="OrthoDB" id="1670656at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="240" mass="27630" checksum="1F4C59B282142038" modified="2004-07-05" version="1">MKKRFCFVIITLLLIFILGSCNKVTSIRRLQELEEGVSNPNTEAELKDAIRKYEKRVDDIMIAEERIGIWYKILGSRYMDQKMYKKALKAFQSALEYYPENQNLFYQAGLAASLTAKNSLDFELTGTDIEKKRYFDLAVSAYKRALEIDPKHAKAVYALSVLYIFELNRPTEAIPILEKITEWEKKPIDHLFLLGAAYYMTGENEKAIAVYERIIEISSSAEKKAKAESNIREIRSSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NM3</accession>
    <name>Q73NM3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971737.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682423.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1129"/>
    <dbReference type="EnsemblBacteria" id="AAS11618">
        <property type="protein sequence ID" value="AAS11618"/>
        <property type="gene ID" value="TDE_1129"/>
    </dbReference>
    <dbReference type="GeneID" id="2739988"/>
    <dbReference type="KEGG" id="tde:TDE_1129"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1090"/>
    <dbReference type="eggNOG" id="ENOG502ZN39">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102199_0_0_12"/>
    <dbReference type="OMA" id="ENGRNDY"/>
    <dbReference type="OrthoDB" id="1180547at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="237" mass="27027" checksum="43DA9DD2B131A981" modified="2004-07-05" version="1">MNKSKKKEWLKKTLFFFIAALLLSCSFDKPEIPELSVKILKIETDAGTIEERLSVFLMYKDENGRNDYSSIQLVHLESGLTWVLNRENTSFFSSSQLRASDSEKTLWAGSNKIASPFGQIPIGEYSVVLEDLSGNRTIKKLTLKEPEMVSSIPFVFRIQDGRWRIEASENSTFKTFFLILLGADKQPLFVQGLPEGSKLEDSISSLFEKYPDTRYIQCMAQNAQGDTAYLTKYHSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NR7</accession>
    <name>Q73NR7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="4">6.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">murC</name>
        <name evidence="14" type="ordered locus">TDE_1085</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="4"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971693.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956876.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1085"/>
    <dbReference type="EnsemblBacteria" id="AAS11574">
        <property type="protein sequence ID" value="AAS11574"/>
        <property type="gene ID" value="TDE_1085"/>
    </dbReference>
    <dbReference type="GeneID" id="2739097"/>
    <dbReference type="KEGG" id="tde:TDE_1085"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1044"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_2_1_12"/>
    <dbReference type="OMA" id="DITYQLR"/>
    <dbReference type="OrthoDB" id="307881at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="11">
        <location>
            <begin position="14"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="13">
        <location>
            <begin position="120"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="12">
        <location>
            <begin position="332"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAS11574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="480" mass="53352" checksum="A0BCDEEE59782E6F" modified="2004-07-05" version="1">MCQVILPDNLKGFKIYMIGIKGTGMTALAEILVSRGAVVLGSDVPENFYTDDALKKLNIDIFSPFSPDNIPDDVGLVIYSAAYSPDNNEEMYAIEQKDLPKMSYPEAIGALSRHSYSCGIAGVQGKTSTTGITGSILKELKLPVSVLAGSVIKSFGDSCTMLNGSKYFVAETCEYKRHFLNFHPKKIILTGIEPDHQDYYPTYESILTAFLQYIDRLPQFSELFYCADDDGACEAARLSFSSRPDLIFIPYGEKASGDYKLTVSGVRDEKLYFSLAGFSGEFYLQIPGKHNALNAAAAIALSVSLLKEEYGEISMANVSAIKKAVSSYAGAKRRTELIGKVESKDILVYDDYAHHPTAIKSLLSGLRQFYPKRRIIADFMSHTYTRTEALLEEFASCFEDADMVILHKIFSSAREKYQGQVDAELLFNRTKKYHKNVFFFNEVLDAKNFVLEKLKPGDIFITIGAGDNYVLGTEILKELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NT8</accession>
    <name>Q73NT8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavodoxin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971672.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682375.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1064"/>
    <dbReference type="EnsemblBacteria" id="AAS11553">
        <property type="protein sequence ID" value="AAS11553"/>
        <property type="gene ID" value="TDE_1064"/>
    </dbReference>
    <dbReference type="GeneID" id="2740825"/>
    <dbReference type="KEGG" id="tde:TDE_1064"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1024"/>
    <dbReference type="eggNOG" id="COG0431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111116_0_0_12"/>
    <dbReference type="OMA" id="MPLNCKM"/>
    <dbReference type="OrthoDB" id="1358314at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="211" mass="23187" checksum="A92583C0905539D1" modified="2004-07-05" version="1">MKIALINGSPKTKNSASGILLEDLKKYLEKNAEVVNFELHLSEIPKEVIEELKKIDTWVFAYPLYVDGIPGHLLSCLIQLEEVSIHKSDLHIYGIVNCGFYEGIHGKLALQILENWCLKAGFIWGGGIGVGCGGALVGMPKTAAGHGPKAAIDKAVAKLSDIIIKGEIQKNNYVSLAFPRFLYKIVGQMRWRKLIKANGGKAKDLGKKYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NW3</accession>
    <name>Q73NW3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD synthase</fullName>
            <ecNumber evidence="4">2.7.7.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TDE_1039</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RibF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="4"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971647.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682349.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1039"/>
    <dbReference type="EnsemblBacteria" id="AAS11528">
        <property type="protein sequence ID" value="AAS11528"/>
        <property type="gene ID" value="TDE_1039"/>
    </dbReference>
    <dbReference type="GeneID" id="2741313"/>
    <dbReference type="KEGG" id="tde:TDE_1039"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.999"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_1_0_12"/>
    <dbReference type="OMA" id="KSASCFI"/>
    <dbReference type="OrthoDB" id="1504821at2"/>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD_syn" evidence="11">
        <location>
            <begin position="30"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS11528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="287" mass="32157" checksum="41354EBD2ACE1E35" modified="2004-07-05" version="1">MDDFKIISWEGLVEAAQSVLTGSDFFPEGKETAISVGGFDGPHKGHDKLLRQVLTYAAENTLVPGLVTFFRSPAAVKNKAYSGDVSSLRLRLKKFQELGFHFIVLIDFSASFAKIEGTAFFDILIKTIRMKYLAVGSDFFCGYRRGLGVDDLKKIAPQKGFCFDSIDPVNRGSLKISSSAIREAVRLGDFSLAKELLGYPFLFDFVSLPWEVKDKNSIFAPKAYISQILPQSGKYRVLVQKTDRQEQEAHCLINDDGLLLCFPEKDSKAFDLKDLNNFDTIEFICKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NY7</accession>
    <name>Q73NY7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemerythrin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hemerythrin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971622.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670476.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1013"/>
    <dbReference type="EnsemblBacteria" id="AAS11503">
        <property type="protein sequence ID" value="AAS11503"/>
        <property type="gene ID" value="TDE_1013"/>
    </dbReference>
    <dbReference type="GeneID" id="2740993"/>
    <dbReference type="KEGG" id="tde:TDE_1013"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.973"/>
    <dbReference type="eggNOG" id="COG2703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086902_2_2_12"/>
    <dbReference type="OMA" id="AKHFKHE"/>
    <dbReference type="OrthoDB" id="1991725at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12107">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016131">
        <property type="entry name" value="Haemerythrin_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035938">
        <property type="entry name" value="Hemerythrin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012827">
        <property type="entry name" value="Hemerythrin_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47188">
        <property type="entry name" value="SSF47188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02481">
        <property type="entry name" value="hemeryth_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00550">
        <property type="entry name" value="HEMERYTHRINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="4">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="137" mass="16799" checksum="64C041F6B4C3D229" modified="2004-07-05" version="1">MDDFVSWDASYDLGIEYVDKQHRRLVELINELYHACLGEKGELEEKFKHVMKELVEYVMIHFKDEEKIMEEINYPNIKEHKQHHENFVKKILQSVNDYRNGKQFVPNTFVRFLRDWLFNHILISDKEWAKFYFANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NZ1</accession>
    <name>Q73NZ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_1009</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971618.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682323.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1009"/>
    <dbReference type="EnsemblBacteria" id="AAS11499">
        <property type="protein sequence ID" value="AAS11499"/>
        <property type="gene ID" value="TDE_1009"/>
    </dbReference>
    <dbReference type="GeneID" id="2740989"/>
    <dbReference type="KEGG" id="tde:TDE_1009"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.969"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_12"/>
    <dbReference type="OMA" id="VMSEITH"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="310"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="411"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="697" mass="75340" checksum="6E95AD75DB92B47F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P34</accession>
    <name>Q73P34_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971575.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682276.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0965"/>
    <dbReference type="EnsemblBacteria" id="AAS11456">
        <property type="protein sequence ID" value="AAS11456"/>
        <property type="gene ID" value="TDE_0965"/>
    </dbReference>
    <dbReference type="GeneID" id="2740773"/>
    <dbReference type="KEGG" id="tde:TDE_0965"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.929"/>
    <dbReference type="eggNOG" id="COG1692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068238_0_0_12"/>
    <dbReference type="OMA" id="NHIWDKK"/>
    <dbReference type="OrthoDB" id="1127353at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005235">
        <property type="entry name" value="YmdB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36303">
        <property type="entry name" value="PTHR36303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13277">
        <property type="entry name" value="YmdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004789">
        <property type="entry name" value="DR1281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="265" mass="29230" checksum="86444B534524B2E8" modified="2004-07-05" version="1">MKQFIKIFMGGDVCGNLGLETLQKHLPLIIKKEKIDFCVVNGENTSHGVGIKDDQTESFFKAGVDIITGGNHTLERFEIRMNFGKDKRVLRPHNFPFAQGSGLALIEKNGIKYSVINLQGRENMRAIDCPFQSIDFLFSSQNENNLSESINIIDFHAESTMEKEALAFYVDGRVSVFAGTHTHTQTADERILPNGTAYITDLGMIGAKESVIGGSPFTAITRTKSQVPQRVEVLEDGVAIFCGLVAEIDTETKKAVSVKRIQISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P79</accession>
    <name>Q73P79_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971530.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="STRING" id="243275.TDE_0920"/>
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        <property type="protein sequence ID" value="AAS11411"/>
        <property type="gene ID" value="TDE_0920"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_AraC"/>
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        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
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        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
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        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="215"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="313" mass="35964" checksum="D99E88D45B2A4E34" modified="2004-07-05" version="1">MQKSYYAFLNHTNSDIVKKDNPYPHFKTYAFSSEIGKGYSAIYDVGSYAHICIADHLYYEDFKYTVPSDEGIYLQQYDSIASDKKYPAGRVYTGMQYIQHYTKVKAVQYVIKKETPACIIGLQLNPEYYGAYLKNTFGITEENFCTKISLLPKENYIPEISFILNQIRKFSGTEASAKLFFKSKVDEIAALLLRKTENIQKAEHSVFSADHAAIMQTIEFINKNLHKRLPLETLAKMSCMSPSKFKYVFKAVTGFSLTDYLVNKKMEKACSLLLNTNMYVANIAQSLGYRSTGYFSACFEKYTGMLPNEYRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P91</accession>
    <name>Q73P91_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0908</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS11399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0908"/>
    <dbReference type="EnsemblBacteria" id="AAS11399">
        <property type="protein sequence ID" value="AAS11399"/>
        <property type="gene ID" value="TDE_0908"/>
    </dbReference>
    <dbReference type="GeneID" id="2739948"/>
    <dbReference type="KEGG" id="tde:TDE_0908"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.879"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="NTHAGNE"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="339"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="583" mass="64181" checksum="9083D7DE528AC2C2" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PE6</accession>
    <name>Q73PE6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsI</name>
        <name evidence="8" type="ordered locus">TDE_0853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0853"/>
    <dbReference type="EnsemblBacteria" id="AAS11344">
        <property type="protein sequence ID" value="AAS11344"/>
        <property type="gene ID" value="TDE_0853"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0853"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.822"/>
    <dbReference type="eggNOG" id="COG0103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_2_1_12"/>
    <dbReference type="OMA" id="QWKINGR"/>
    <dbReference type="OrthoDB" id="1766414at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="124" mass="13625" checksum="A002DE3762605F12" modified="2004-07-05" version="1">MGTGRRKTSVARVYIRDGKGQLTVNDKDINEYFATPEQVQKAKEPLMVTAGESKYDIIITVRGGGLTGQAGACSHGIARALAQVDASNHASLKANGLLTRDSRMVERKKFGQRGARRRFQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PK5</accession>
    <name>Q73PK5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971404.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672197.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0794"/>
    <dbReference type="EnsemblBacteria" id="AAS11285">
        <property type="protein sequence ID" value="AAS11285"/>
        <property type="gene ID" value="TDE_0794"/>
    </dbReference>
    <dbReference type="GeneID" id="2740672"/>
    <dbReference type="KEGG" id="tde:TDE_0794"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.767"/>
    <dbReference type="eggNOG" id="ENOG5031ARI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131456_0_0_12"/>
    <dbReference type="OMA" id="AAYLQEC"/>
    <dbReference type="OrthoDB" id="1723007at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012650">
        <property type="entry name" value="CHP02328"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004260">
        <property type="entry name" value="Pyr-dimer_DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03013">
        <property type="entry name" value="Pyr_excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02328">
        <property type="entry name" value="TIGR02328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="120" mass="14551" checksum="951D3E93B0D6F19E" modified="2004-07-05" version="1">MRLWHQNLINRLPAQQLLGQHRECCALRGNGWGKKHSVVDYVFLYSPYKLFQYHELVMEEMNKRGYKVSEEWLDKNYRGKKCPPYADLKKIKKTSPIYKEHDEKYMQECITNLREKNIEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PL4</accession>
    <name>RL30_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmD</name>
        <name type="ordered locus">TDE_0785</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971395.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670028.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PL4"/>
    <dbReference type="SMR" id="Q73PL4"/>
    <dbReference type="STRING" id="243275.TDE_0785"/>
    <dbReference type="EnsemblBacteria" id="AAS11276">
        <property type="protein sequence ID" value="AAS11276"/>
        <property type="gene ID" value="TDE_0785"/>
    </dbReference>
    <dbReference type="GeneID" id="2740663"/>
    <dbReference type="KEGG" id="tde:TDE_0785"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.758"/>
    <dbReference type="eggNOG" id="COG1841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131047_1_3_12"/>
    <dbReference type="OMA" id="GKQNQRD"/>
    <dbReference type="OrthoDB" id="2084745at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_L30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000056127" description="50S ribosomal protein L30">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <sequence length="61" mass="6665" checksum="522F8B82C513075E" modified="2004-07-05" version="1">MAKRISVKLVKSTIGQKQPVCSTIRSLGLKKLNSTVEHDANPAVLGMVKRVAHLVEVKELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PR7</accession>
    <name>Q73PR7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA_pol3_delta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971341.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681969.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0729"/>
    <dbReference type="EnsemblBacteria" id="AAS11222">
        <property type="protein sequence ID" value="AAS11222"/>
        <property type="gene ID" value="TDE_0729"/>
    </dbReference>
    <dbReference type="GeneID" id="2740093"/>
    <dbReference type="KEGG" id="tde:TDE_0729"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.705"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821204_0_0_12"/>
    <dbReference type="OMA" id="WQFKRLL"/>
    <dbReference type="OrthoDB" id="1199768at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="10"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="338" mass="38393" checksum="6388D462045A1764" modified="2004-07-05" version="1">MANPVWLFMGPEIGERNTAVDTVLKTLSKQYGDIETHTVYAGDAGMGDVISLLQNASLFSSAKLIILKSAELIKKKEDIDLLTDWIQSVSKKENTSDSFLILISDETSIAKKISDTVPKTQQKIFWELFENKKQEWVRSFLFREGIEIEDEAVDELLELVENNTDALKMACSHLVLYFQKGSHIDQENIEKLFAHNKEETPFSLFNALTMGSLETALSISQKIILSKNSSPVQIIAGLSYCFRRLQDWHKIHRDNEYLDDFALKRFGFLGKTALAQYKRAAKLWNEVQCVKIIALLSETDLELRSLGTSLQNIVMDMCLYEIACKSGNKIEKYTADNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q14</accession>
    <name>Q73Q14_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma factor regulatory protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971244.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672386.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0630"/>
    <dbReference type="EnsemblBacteria" id="AAS11125">
        <property type="protein sequence ID" value="AAS11125"/>
        <property type="gene ID" value="TDE_0630"/>
    </dbReference>
    <dbReference type="GeneID" id="2739355"/>
    <dbReference type="KEGG" id="tde:TDE_0630"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.608"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564906_0_0_12"/>
    <dbReference type="OMA" id="KMTIRYV"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="262"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="483" mass="54519" checksum="F1F3AFAFB83C110D" modified="2004-07-05" version="1">MIKLRKLLSNILISVGMGSVFALFLIFVSPRFLFLGKFYSANDMTLALSRLEIIPEITQIHRFIIGSLVFVIVAIFADSLIRSFYKKIESRAYDKPKTKVFAEFLKKIRFCYTIENLIDTVQNELEYSGDCSVMLVDTIENIVLYNSASRFISSPETFSSLHEITVEYKPGVYFFNADMQGCKLKDARIAAVILEKIQFFIICGYFNEVEPEIFNTLFSEFLSYQNRVTTLEQLLYFSELSQEWNMVANTQKAFLPQKLPEMPMLELAAYFKPLVNVSGDYYDAIKVDEHKTLLVVGDVSGKGLSAALVMGIVVNTIKIAKNKEDLPALVLAVDSAIKRMGLLDKYTVLFLGLVDTEKMTIKYVNASMEDPMILTESPDGYKVKVLESTCSIVGIIDFDKIEVHERPLYRGDVILMMTDGVPEAMNNEGVELAETDMYMESIKSFVQYSADDIVQKVAGMAYAHAGNQPMRDDITIMCAKVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q18</accession>
    <name>Q73Q18_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971240.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681812.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73Q18"/>
    <dbReference type="STRING" id="243275.TDE_0626"/>
    <dbReference type="EnsemblBacteria" id="AAS11121">
        <property type="protein sequence ID" value="AAS11121"/>
        <property type="gene ID" value="TDE_0626"/>
    </dbReference>
    <dbReference type="GeneID" id="2740471"/>
    <dbReference type="KEGG" id="tde:TDE_0626"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.604"/>
    <dbReference type="eggNOG" id="ENOG502Z8AD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021406_1_1_12"/>
    <dbReference type="OMA" id="EAQHIVM"/>
    <dbReference type="OrthoDB" id="1102171at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025584">
        <property type="entry name" value="Cthe_2159"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14262">
        <property type="entry name" value="Cthe_2159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285890" evidence="2">
        <location>
            <begin position="25"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="504" mass="52942" checksum="33CC95B60152AD63" modified="2004-07-05" version="1">MKINKKLVKTVCMFFLALSLLNCRSEDRFPIGRMEVNLKTPVQRDTSKLFSDKDFKTEYGSSKVVSVNLSALSGISAKGLTVNGNTVTINEGGQYIISGSLNDGQIIVDAPDNDEVHLILDNADISNSSMPVIYAKKAGKMLITLAKGSKNKLNVNGKFADSDAGKTNAVIFSQTDLTLNGTGELNIESKYGSGIVSKKDLRVTGGSFTVSASKHALKGCDNVSIADGKFTLTAGKDGIHSENEENAESGNIYIKNGEFTINAASEALDAINDITIDGGYINIAKADEGMEALTININGGKIMVVSSDDGLNASYSDKEEIEAKLSGTALTDNSSKKTEKKGPPVLSESAASTYVNITGGEVTINSQADGIDSNGSVYVSGGKVNILGPVSDGDAALDYDLTALISGGEFIASGSRGMVQGFSDKSTQASFIANFSKTVKGEVIVSDSSGAVILKTNQDKDFQSIVVSSKGLKVGETYKITAGGQTLTVKMDSISVGDNMHKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q19</accession>
    <name>Q73Q19_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971239.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0625"/>
    <dbReference type="EnsemblBacteria" id="AAS11120">
        <property type="protein sequence ID" value="AAS11120"/>
        <property type="gene ID" value="TDE_0625"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0625"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.603"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_12"/>
    <dbReference type="OMA" id="GHDHVHP"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="256" mass="28880" checksum="3FD9AAAC1761B1A8" modified="2004-07-05" version="1">MLRIEDLSLSYGDKPVVQNLNLKVKKGQVVSIIGPNASGKSTILKSIAGIIKPVSGKIFIEEKDISKMDSKKLAQKVSILLQQNKNPDDMSIEELVYFGRYPHKKWFEGFEASDQKIIEEAMKLTNTFALRDKTLETLSGGERQRAWIAMALAQEPDILLFDEPTTYLDLAHQIEFLELVNRLNKETGVTVVLVLHDLNQAARYGNYLFAMKEGKIFAQGCPEEVLNPQNILNIYNIEAKIFNAAGYPVVIPERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q38</accession>
    <name>Q73Q38_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ParB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971220.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681789.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0606"/>
    <dbReference type="EnsemblBacteria" id="AAS11101">
        <property type="protein sequence ID" value="AAS11101"/>
        <property type="gene ID" value="TDE_0606"/>
    </dbReference>
    <dbReference type="GeneID" id="2739162"/>
    <dbReference type="KEGG" id="tde:TDE_0606"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.586"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_0_12"/>
    <dbReference type="OMA" id="IALSYQR"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="35"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="297" mass="33378" checksum="9B86C0830C4D6C09" modified="2004-07-05" version="1">MAKKSALGRGLNALLEEQPANQIVESLNISEDSIINIDPKLLQPNPYQPRKTFDEEKISELAESIKEHGIIQPIVAEKHEDKGYFIIAGERRTRAAISLGLETVPVILRSFEEKKKLEVALIENIQREDLNAIDEALAYQEIMELAAINQEELAKRVGKSRSAITNSLRILKLPEEMKDALRVNKITAGHARSLLSIVNPADQKILFSRILESELSVREAESMAADLNSGIGRITKKQKKETQSLSTDDFELRDIEQQFINSLGTKVQIKGNLKKGVVEISYFSKDDLDMLYKKINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q43</accession>
    <name>Q73Q43_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971215.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0601"/>
    <dbReference type="EnsemblBacteria" id="AAS11096">
        <property type="protein sequence ID" value="AAS11096"/>
        <property type="gene ID" value="TDE_0601"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0601"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.581"/>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030558_0_1_12"/>
    <dbReference type="OMA" id="AANYNCP"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="7"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="325" mass="34806" checksum="9DDB0CEE91AB10B3" modified="2004-07-05" version="1">MMNSIFLFSGQGAQFKGMAQDIVDEYGAAKDLIKKIGDITGEDIDALLRHTENEELSRSDKSQLAIIAVETAILAVLKEKGISPKAVAGFSLGEFSALYASGILSFDDMIRIVQKRGTIMQAACDKIAARATEGSGALGMSAILKLEPEKVLELLKPYSDPKSGIVFAANMNSPVQTVISGTAEGLSLAEDLCKEAGAKRCVRLAVAGPFHSPLMEEAAKEFEEVLKSFDFKAPQIPVFSNVTGKQVKSGEEAKANAVLHLTHPVLWTSEEKEIASLSGSLKPFRLLEVGPGNTLCNLWRDSGFASDELACSPTGTLEQLNKIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q69</accession>
    <name>Q73Q69_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971188.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0574"/>
    <dbReference type="EnsemblBacteria" id="AAS11069">
        <property type="protein sequence ID" value="AAS11069"/>
        <property type="gene ID" value="TDE_0574"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0574"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.557"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034334_6_2_12"/>
    <dbReference type="OrthoDB" id="956253at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="285" mass="30667" checksum="8D6DF9B09656D2C2" modified="2004-07-05" version="1">MGEIIKESDKRVALKLPANVTEIDDRAFLGCTRLESIDLSACTSLTAIKLAAFKGCTSLKAVQLPQSLTTIGHFAFEGCTALKEVELPQNLTVIGTDAFKGCSIETLVIHCDIKGTIIENFTKKDEVNKNVKKLTLGKGVTTIGNYAFYIIGYSKLAAVDFSACTALTEIGENAFAYSKLTNVNLSACIKLTEIGKSAFSNCTDLTNVDLSGCTALTTIGEQAFNSCYEATVKLPTGITAIGNEAFGENDEDFLCKNVLIPRSHAATIKPLVTASDYPEDRIREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QA4</accession>
    <name>Q73QA4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971153.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0539"/>
    <dbReference type="EnsemblBacteria" id="AAS11034">
        <property type="protein sequence ID" value="AAS11034"/>
        <property type="gene ID" value="TDE_0539"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0539"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.525"/>
    <dbReference type="eggNOG" id="ENOG5032ZCI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2195762_0_0_12"/>
    <dbReference type="OrthoDB" id="1846896at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="108" mass="12606" checksum="903A7B1B92DB76D2" modified="2004-07-05" version="1">MTISKQCIINPDGIVSMQFSDNTDTALRTIKHDDIKAITDILNTAKYDDERNDGKMFKMTAPQLRIVIRYSDDSEVKIQLWDALMYVNKTWYKLDIRAIKEILYGKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QE6</accession>
    <name>Q73QE6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971111.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681619.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0497"/>
    <dbReference type="EnsemblBacteria" id="AAS10992">
        <property type="protein sequence ID" value="AAS10992"/>
        <property type="gene ID" value="TDE_0497"/>
    </dbReference>
    <dbReference type="GeneID" id="2738982"/>
    <dbReference type="KEGG" id="tde:TDE_0497"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.482"/>
    <dbReference type="eggNOG" id="ENOG5032MU6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1729651_0_0_12"/>
    <dbReference type="OrthoDB" id="1354449at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="168" mass="19603" checksum="79AC98F2D2D3BC07" modified="2004-07-05" version="1">MRRITFQCNKYSPGVLYIMVLFGVTLGLLTFYAFLVFSGIEKGPEHGPVYFREHPMHAVYLIFGLISIAMSLPAWIAAKCWSSKEEEAQLELYEDHAVLYWKNKELHIKQGALNIKIPKPQPYWYKTYVLKIPKHRVVLVGSVKETKEKRRRQLSLDIAIEELSVYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QE7</accession>
    <name>Q73QE7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971110.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681617.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0496"/>
    <dbReference type="EnsemblBacteria" id="AAS10991">
        <property type="protein sequence ID" value="AAS10991"/>
        <property type="gene ID" value="TDE_0496"/>
    </dbReference>
    <dbReference type="GeneID" id="2738981"/>
    <dbReference type="KEGG" id="tde:TDE_0496"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.481"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_47_7_12"/>
    <dbReference type="OMA" id="SECGPVP"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="72" mass="7916" checksum="7716270CB696D994" modified="2004-07-05" version="1">MNRIAEFIKTSRKSAGLTQEDFAIRAGLGLRFVRELEQGKETVRMDKVNVALAMFGMEAVPGKKEGVTSATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QM2</accession>
    <name>Q73QM2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971035.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956739.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0421"/>
    <dbReference type="EnsemblBacteria" id="AAS10916">
        <property type="protein sequence ID" value="AAS10916"/>
        <property type="gene ID" value="TDE_0421"/>
    </dbReference>
    <dbReference type="GeneID" id="2739585"/>
    <dbReference type="KEGG" id="tde:TDE_0421"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.408"/>
    <dbReference type="eggNOG" id="ENOG5031D4M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049884_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010103">
        <property type="entry name" value="Clustered_lipoprot_TREDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09710">
        <property type="entry name" value="Trep_dent_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01781">
        <property type="entry name" value="Trep_dent_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="428" mass="50209" checksum="32331E2BB312161C" modified="2004-07-05" version="1">MKKNKLKLIIILILAVLLFSCSKEVKEQNSAETKVESSAKIEPKENEFLSKPEYNTHVKSPEQIKELEEKYKRSEAYEEKLKQLGAELDKKEKILNYKFPTGITIDELAQQKAPVLYSPADNLEFIHFYEIKKDGEFCYCKYKAPTQNGGTLDYQVTYKWYNIEQMYLPLSYNLLSENNMGRINEELIENQVHGSVYSMENDEKKDEMIKLFEDYENTQYPLFKEVVHTDWDTGVKTIGYKQYDMRILDYVKGNFTNSGYDEYFVMFYEDDPDPEIYDQFIERVRCFVVSEGKIISDYYISNSGGFFYPGLSNDKLSEVEAFGFKFSQGWIADFNQNGINEIYLAAFFNIEGGGLLMVEYNDGSFVTGYVYGDRYDIVSVDWYKKIIIIKDKSGNGEWIDDYQWNDTLKEFILYKEQILGGLRNEKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QQ2</accession>
    <name>Q73QQ2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3343 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971005.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666122.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0391"/>
    <dbReference type="EnsemblBacteria" id="AAS10886">
        <property type="protein sequence ID" value="AAS10886"/>
        <property type="gene ID" value="TDE_0391"/>
    </dbReference>
    <dbReference type="GeneID" id="2740323"/>
    <dbReference type="KEGG" id="tde:TDE_0391"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.380"/>
    <dbReference type="eggNOG" id="ENOG5030WMC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167443_0_1_12"/>
    <dbReference type="OrthoDB" id="1844146at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021778">
        <property type="entry name" value="Se/S_carrier-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11823">
        <property type="entry name" value="DUF3343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3343" evidence="1">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="82" mass="8958" checksum="4397772B76F44C5E" modified="2004-07-05" version="1">MNYIITFGTTTAAIQCDSMIKADPINAKLVPIPGFLKAGCGFACLFQNAQKEEVESWIGKNNISYETLIEVIYENGLISPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QU7</accession>
    <name>Q73QU7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protease PrtB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">prtB</name>
        <name evidence="8" type="ordered locus">TDE_0346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970960.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0346"/>
    <dbReference type="EnsemblBacteria" id="AAS10841">
        <property type="protein sequence ID" value="AAS10841"/>
        <property type="gene ID" value="TDE_0346"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0346"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.335"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062149_0_0_12"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Cache" evidence="7">
        <location>
            <begin position="57"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS10841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="274" mass="30388" checksum="A50800A2668FEF36" modified="2004-07-05" version="1">MTKNGGIFSKGNNEKNQIAKTGKKRFSLRKKLVLIFGFLIAAALTTAALITIGNARKAVLEKVEAHLTDKATDIAEVIDGRISSVVQFIEGLARMPFLRDNSMTLTEKAELLIKEAERNKKIDYFGICDMQGNRYDGTGHRTSVRDREWFKSASQGKNFITEPAISNITNNMQIIFAVPIYDDDNAIIGVLNAAVPAKLLSEEIDDIVVGQTGECYILGLKGTVIAHKNFDMVTKQRNIIKDNSDKNFASLAAFLQHALDTDKSEVGYYDYDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QW3</accession>
    <name>Q73QW3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, SAG0897 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970944.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681294.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0330"/>
    <dbReference type="EnsemblBacteria" id="AAS10825">
        <property type="protein sequence ID" value="AAS10825"/>
        <property type="gene ID" value="TDE_0330"/>
    </dbReference>
    <dbReference type="GeneID" id="2741546"/>
    <dbReference type="KEGG" id="tde:TDE_0330"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.319"/>
    <dbReference type="eggNOG" id="ENOG5032YV1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107519_1_0_12"/>
    <dbReference type="OrthoDB" id="1964096at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11940">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010146">
        <property type="entry name" value="CRISPR-assoc_prot_Csn2-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038600">
        <property type="entry name" value="Csn2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09711">
        <property type="entry name" value="Cas_Csn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01866">
        <property type="entry name" value="cas_Csn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="224" mass="26182" checksum="EED34EABCBF8BEA3" modified="2004-07-05" version="1">MKLVHPDIKNQIIFSENKVNVLTIENKTFFTEFVSELFSQYSGNEGKFILSEDDKELSIPKTCELILNPINLDINNKQNLNKIYSILKQSISDEYNYLKTCTIKSEILKHIDDVLLSLDIPLKRSEELDLISIFKAVNISFETEYTNLLEKIIDYISASVELNQIKCFIFINLKQFLHFKDLSELYKFACYIKTNLFLIEGSYTSTKEDCEKSYIIDKDLCEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R02</accession>
    <name>Q73R02_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970905.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681231.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0291"/>
    <dbReference type="DNASU" id="2741382"/>
    <dbReference type="EnsemblBacteria" id="AAS10786">
        <property type="protein sequence ID" value="AAS10786"/>
        <property type="gene ID" value="TDE_0291"/>
    </dbReference>
    <dbReference type="GeneID" id="2741382"/>
    <dbReference type="KEGG" id="tde:TDE_0291"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.280"/>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166037_0_1_12"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="88" mass="10023" checksum="BA36F66117424826" modified="2004-07-05" version="1">MFIPQIVPIRDLKNTSAISNLCHKTNEPIFITKNGYGDMVIMSMETYEGNAFFNNLYGNLEEAEMDLQNGRVSGIDEAIEEIKSRYDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R10</accession>
    <name>Q73R10_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970897.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681221.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0283"/>
    <dbReference type="EnsemblBacteria" id="AAS10778">
        <property type="protein sequence ID" value="AAS10778"/>
        <property type="gene ID" value="TDE_0283"/>
    </dbReference>
    <dbReference type="GeneID" id="2741600"/>
    <dbReference type="KEGG" id="tde:TDE_0283"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.273"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076847_2_0_12"/>
    <dbReference type="OMA" id="SWITQPT"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="234" mass="26116" checksum="4A7ED792C3A5CF24" modified="2004-07-05" version="1">MFLDPRTKLLILAITSVSVFLNESTLIEGAFTFIPFLLLLQAKHIRLAFKSGAAFIILLALPMLLVPHLPVTAGGILYMFAVYIRKLIPCFMLGSLLIRTTKVSTFLAAISRLHLPKGFTIALSITLRYFPTMTEEWGFIKDAMSLRGISVSPAGLLFHPVRTMEYVYVPMLVSASKISDEITQAAITRGIDHLERRSCLENIRFRMMDALLLLLYLSLVVLIIFNSVKGAVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R39</accession>
    <name>Q73R39_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970868.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681178.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0253"/>
    <dbReference type="EnsemblBacteria" id="AAS10749">
        <property type="protein sequence ID" value="AAS10749"/>
        <property type="gene ID" value="TDE_0253"/>
    </dbReference>
    <dbReference type="GeneID" id="2739678"/>
    <dbReference type="KEGG" id="tde:TDE_0253"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.248"/>
    <dbReference type="eggNOG" id="ENOG502Z9IN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_530829_0_0_12"/>
    <dbReference type="OMA" id="KPEWLAQ"/>
    <dbReference type="OrthoDB" id="1083197at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="497" mass="57781" checksum="3C62D2808EFDBF6E" modified="2004-07-05" version="1">MKAKSGDVYCVYNSYLKKYTACQITKIEEGDKKPKAVQLWLDWSGEQPLKEEELPLLKPLYQDFMYWKRGLHLCNVDVMVPANHMLIGNMQPLTDESTNTYARSWGNGYEVYRQLKWQEIPKEQRDAFKKAESSKEKIIFAGKEMAVSRHRIHDDVPFENVLELKAFPCLSYLACKKWHIGLYEYLQSCPFLDELVLENHQQKRLDFSNAHLHRLSIDMNGVEELYLNNELEELILLGEVTNNCKIHAVENGALLLLTATKIVPKIQELKDLGKLHCSEITELDVAEILKAYPMLRELRLWGKPGILSNLSMLSRFRKLEGFTTVDLFGFSAEDIPEPDRLPNLHWFWMSSLPENAAKKAKQLYKKRKEEGLDLWIQKPRKPEWLAQNLDNPFRSWDGQENISAANAKKAADLYKKTRAEILKLEQSSPIEAARTAEALVRAYTEAFNKMDKRKYFIETVEREDIYCALTELLDLIPPSLSINKEKLLEIFDTIRDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-13" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RB6</accession>
    <name>PCP_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyrrolidone-carboxylate peptidase</fullName>
            <ecNumber evidence="1">3.4.19.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-oxoprolyl-peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pyroglutamyl-peptidase I</fullName>
            <shortName evidence="1">PGP-I</shortName>
            <shortName evidence="1">Pyrase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pcp</name>
        <name type="ordered locus">TDE_0175</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes 5-oxoproline from various penultimate amino acid residues except L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.</text>
            <dbReference type="EC" id="3.4.19.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.3" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970791.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681058.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73RB6"/>
    <dbReference type="SMR" id="Q73RB6"/>
    <dbReference type="STRING" id="243275.TDE_0175"/>
    <dbReference type="MEROPS" id="C15.001"/>
    <dbReference type="EnsemblBacteria" id="AAS10672">
        <property type="protein sequence ID" value="AAS10672"/>
        <property type="gene ID" value="TDE_0175"/>
    </dbReference>
    <dbReference type="GeneID" id="2739348"/>
    <dbReference type="KEGG" id="tde:TDE_0175"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.172"/>
    <dbReference type="eggNOG" id="COG2039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043960_4_0_12"/>
    <dbReference type="OMA" id="HHIATRA"/>
    <dbReference type="OrthoDB" id="1927224at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="entry name" value="PYROGLUPTASE"/>
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    <keyword id="KW-0788">Thiol protease</keyword>
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            <end position="217"/>
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    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
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        </source>
    </evidence>
    <sequence length="217" mass="23082" checksum="F1C30CA6E747A7AB" modified="2004-07-05" version="1">MKILVTGFDPFGGEKINPALETIKLLPNEILGAKIIKLEIPTVIGKSVAKIKDMIEKENPDVVLSIGQAGNRADISVERIGINIDDCRIPDNEGNQPIDEPVVKDGPAAYFVTLPIKAIVEKVKAGKIPASISNTAGTFICNHVCYGVAHIAAARTAQGKPMKSGFIHIPFLPEQVIGKPALTPSMSLEMIVKGIELAIEAIVQNNSDIKVSGGKIC</sequence>
</entry>
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    <name>Q73RD7_TREDE</name>
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    </protein>
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        <name evidence="6" type="ordered locus">TDE_0152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
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            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="39"/>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS10650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="451" mass="48813" checksum="4AEF6C66F4DCF6F0" modified="2004-07-05" version="1">MEDKKIPAKVKGLSKFDVLNLVIGSIIGWGSFILPGTLFLPNSGVINTVLGLCIGGLFVIVIQKAYQVMLSNHVGEGGEFSYTLTNMGKVHGFIVGWSLSLCYLSMIPLNATAYVLILRKIFGKVMLWGYMYDFGPTSVYLADILIASVPIIVFTIVNLKGLSLSTKIQNIMSSALVLIVIVLFFIILGKSNLKVFSDNYLGYDKISLAKTASIIAIIPFLFVGFDVVPQVSCDLGFAPSKTHLPTIISIIFGILLYSLLNMIGALSYGPEEAAKVEWAVASSVTSKTGFIGFFFLLIAIFSAVTGGINGFMISSSKLLGALSNEKLSPAFLGKKNDKNLYPNAILFIAGVSLIGPWIGREVIILIVDMASVLAALAYTYVGIIGIRKGKNLFEKTMCAFSGLIGLIFISLLLIPGSPAQLTKGSMFFLIAWTLLGFLFYRFGTRRKEKST</sequence>
</entry>
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    </gene>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Tettelin H."/>
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                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
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                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    </dbReference>
    <dbReference type="GeneID" id="2739442"/>
    <dbReference type="KEGG" id="tde:TDE_0130"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
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        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="457" mass="48352" checksum="3009ED6175699C2E" modified="2004-07-05" version="1">MDIIWICGIVAAALLLMYGIRYMKKLNMSFNVRVVTALVVGIIFGAILQLTVKDSALIKKAMSWITLVGSGYVRLLRMIVYPLIIVSITKSIATQKQNIGKAAGRILAVLVITVAIAALVGALTTSAFGLSAENLTAGESEIARGKAMEGRLHDFEAKPIQQQILEIIPTNPFYAFSGQGSNATLATVFFSAMLGFAALFLKRSNPDSADVFIKWLNSCSDVVMRLVRMVLRITPYGVLALMINITSTSNFSEILRLIGFIGASYIAIIIMFVVHGLYLLTAGLNPITFFKKSVSNLMFAFTSRSSAGALPLTVSNQVNNLGVPEGIANLAGSLGTSIGQNGCAGIYPAMLAVMIAPTLGINPLAPVFLVKLIVITALGSFGIVGVGGGATFAAIIVLSSMGLPITLAGLLVAIEPLIDMGRTALNVSDSLLSGVIAAKRTGELDESIYNRKEIIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RG5</accession>
    <name>Q73RG5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970740.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666686.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0123"/>
    <dbReference type="EnsemblBacteria" id="AAS10621">
        <property type="protein sequence ID" value="AAS10621"/>
        <property type="gene ID" value="TDE_0123"/>
    </dbReference>
    <dbReference type="GeneID" id="2741738"/>
    <dbReference type="KEGG" id="tde:TDE_0123"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.123"/>
    <dbReference type="eggNOG" id="ENOG50343I0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104224_0_0_12"/>
    <dbReference type="OMA" id="PWGDPGL"/>
    <dbReference type="OrthoDB" id="1992481at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285042" evidence="1">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="226" mass="26123" checksum="458EA19CA85F1D72" modified="2004-07-05" version="1">MRKFIAVLLFFISFYLYADTYSGSSDSDALIVRAPVWVFVEEAPKGIDDENKAKFTPPKEALLELSAYILSGMTYGLNFVYTPLDKKRNVEEYFELEPVFKPSTENIKITDVRVKYPYCYSWAEYGIPESYAGHFKLWTKNAHKTIKGRGKGDRFDELEGVYAAYTEAVKNAVREYARTFLKNKPKEIRGAVLIKSPPRLFVESGFFKAELELYIQIDEIIKYTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RG6</accession>
    <name>Q73RG6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="1">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970739.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680981.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0122"/>
    <dbReference type="EnsemblBacteria" id="AAS10620">
        <property type="protein sequence ID" value="AAS10620"/>
        <property type="gene ID" value="TDE_0122"/>
    </dbReference>
    <dbReference type="GeneID" id="2741737"/>
    <dbReference type="KEGG" id="tde:TDE_0122"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.122"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_0_3_12"/>
    <dbReference type="OMA" id="EYFTEMI"/>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0288">FMN</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="3">
        <location>
            <begin position="6"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="337" mass="38195" checksum="3CF6D7706F82CA8C" modified="2004-07-05" version="1">MKLISAPMAAITHSAFRRLAACFKEPDEYFSEMIHAPSAISGGGFEKWYFRANPSPEKLVWQITSPDEKSAAACVPLLLQYGGFGIDLNMGCCAPQIVNTGAGFAWMKKPLSETASLVSKVKKAVLLYDEQKAGPQTEPIRLSVKLRLGEEENYDRLLSFCKMLVSEGVDLITLHPRTQKQKYSRPCKHEYTARLASDLSVPVYGNGDINSLETLEKIASKYPCAGWMIGRAAVQKPWIFYELSKGILKNGTAEDKDEKIEIDLLKTAELFLSFLREEQPQEFYLTRAQRFFAFFCDNFSFAHHIKSKVLNCKNLEDMFHSLSDYFEEVPEDRLIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RG8</accession>
    <name>Q73RG8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F420_ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970737.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666702.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0120"/>
    <dbReference type="EnsemblBacteria" id="AAS10618">
        <property type="protein sequence ID" value="AAS10618"/>
        <property type="gene ID" value="TDE_0120"/>
    </dbReference>
    <dbReference type="GeneID" id="2741735"/>
    <dbReference type="KEGG" id="tde:TDE_0120"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.120"/>
    <dbReference type="eggNOG" id="COG1478">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_626686_0_0_12"/>
    <dbReference type="OMA" id="FTGVDYI"/>
    <dbReference type="OrthoDB" id="753699at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="399" mass="44153" checksum="207B9EC278CEDF3A" modified="2004-07-05" version="1">MKKFVGTISRGLIAPIIREGDDIASIAAETLLNAAKAENFTIKDRDILSVTESIVARAQGNYATADDIAADIKAKFGNSCIGLIFPILSRNRFSVCLEGIARSKNKLIIMLSYPSDEVGNHLIDPDVFEDSDVNPWTNSFTREEFRSKFGDHKHKFTGMDYIEYYDSIIKKHNPESFVILSNDPKKIIEYTDSVLACDIHTRNRTKKLLKKAGAKTVLGLDDILSSPVNGSGFNSDYGLLGSNKSGEDRVKLFPHNAQVIVDKIQAIIKEKTGKTIEVMVYGDGAFKDPIGKIWELADPVVSPAYTKGLEGKPNEVKLKYLADNNFKGLSEEEQKKKIAEYIEKHQKETASHIDSMESQGTTPRRLIDLIGSLSDLTSGSGDKGTPIIFIQGYFDKYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RP0</accession>
    <name>Q73RP0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0045</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="351"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="394"/>
            <end position="401"/>
        </location>
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        </ligand>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
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        </source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AAS10531">
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    <dbReference type="KEGG" id="tde:TDE_0033"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.35"/>
    <dbReference type="eggNOG" id="COG3279">
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    </dbReference>
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    <dbReference type="OMA" id="THISART"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:phosphorelay signal transduction system"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="239" mass="27871" checksum="2CD437142E7DCC21" modified="2004-07-05" version="1">MLKIAVIEDNEVQSRLLKDYANEWANKNNLLPEIKLFSSGEQFWFEFEELSDIDIILLDIQMSRISGIELAKKIRKTKSDAVIIFITGIPDYMQEGYDVEALHYLLKPVKKEKLFDCLDRALKKQDKVKEENFVFSCEGRLTTLKQSEIVFIESISHNLKIKTLKSEYITRMNLSEAEEKLNSKLFVKTHRAFIANLMHIRQLQKDKAVLADNTLIPISRREYKNVNTLFIGFFTQGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F7IU92</accession>
    <name>F7IU92_TREDE</name>
    <protein>
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            <fullName evidence="8">Flagellar protein FliL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fliL</name>
        <name evidence="9" type="ordered locus">TDE_2764</name>
    </gene>
    <organism evidence="9 10">
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
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                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Controls the rotational direction of flagella during chemotaxis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliL family.</text>
    </comment>
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        <property type="protein sequence ID" value="AAS13281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666989.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2764"/>
    <dbReference type="EnsemblBacteria" id="AAS13281">
        <property type="protein sequence ID" value="AAS13281"/>
        <property type="gene ID" value="TDE_2764"/>
    </dbReference>
    <dbReference type="GeneID" id="2740731"/>
    <dbReference type="KEGG" id="tde:TDE_2764"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2608"/>
    <dbReference type="eggNOG" id="COG1580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126053_0_0_12"/>
    <dbReference type="OMA" id="VITYRIM"/>
    <dbReference type="OrthoDB" id="1770108at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005503">
        <property type="entry name" value="FliL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03748">
        <property type="entry name" value="FliL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS13281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="181" mass="20649" checksum="22546988D045E1D1" modified="2011-07-27" version="1">MADNDLMDDDDIQENMASSVDTKKRGAGLIPMLIKWVAIVLVALIFIVTVVVITMNIRDKKGSSHSISPVSEEYRETRDVLQWYQAIGILKVHTADRIPATLIVDVALGYTNNDKSTPQELSARKVEIIDFLRSYFKGKTTAELRQEEKIKIEIKHEINDNVLTKNKIKDVRFTQYDIVEQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>P61070</accession>
    <name>RL4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplD</name>
        <name type="ordered locus">TDE_0768</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971378.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669996.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61070"/>
    <dbReference type="SMR" id="P61070"/>
    <dbReference type="STRING" id="243275.TDE_0768"/>
    <dbReference type="EnsemblBacteria" id="AAS11259">
        <property type="protein sequence ID" value="AAS11259"/>
        <property type="gene ID" value="TDE_0768"/>
    </dbReference>
    <dbReference type="GeneID" id="2740308"/>
    <dbReference type="KEGG" id="tde:TDE_0768"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.741"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_12"/>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="OrthoDB" id="1572673at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000129303" description="50S ribosomal protein L4">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="211" mass="23571" checksum="24DACF52D30A0A0E" modified="2004-04-26" version="1">MEKKVYSVDGKELRTINLDDKVFGLPVNDDVIYYAINNELANKRVGTACTKGRAEVHGSNSKPYSQKGTGRARRGDKKSPLLVGGGTIFGPKPRDFSYSMPKKAKRLAMKSILSLKAQNDRLVVVEDFTVESGKTRDLVKILDNFAKGERAVIILKDDDSLVKRAGRNIPHLSFLAYNRLRAHDLFYGRKVIMLESAAKNLSEFYGCKEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J62</accession>
    <name>Q73J62_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973312.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73J62"/>
    <dbReference type="STRING" id="243275.TDE_2714"/>
    <dbReference type="EnsemblBacteria" id="AAS13231">
        <property type="protein sequence ID" value="AAS13231"/>
        <property type="gene ID" value="TDE_2714"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2714"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2564"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_1_2_12"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="424"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="663" mass="73955" checksum="4BAE3B0C5765F42E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J98</accession>
    <name>Q73J98_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973275.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13194">
        <property type="protein sequence ID" value="AAS13194"/>
        <property type="gene ID" value="TDE_2677"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2677"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2529"/>
    <dbReference type="eggNOG" id="ENOG502ZMPU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_210964_0_0_12"/>
    <dbReference type="OrthoDB" id="2090492at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="44" mass="5181" checksum="1552C1AE87D835EE" modified="2004-07-05" version="1">MSYKLDGAKFPTLEELVEALYPIYSDKMSEEEFKKYAEENAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JA7</accession>
    <name>Q73JA7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">glyA</name>
        <name evidence="10" type="ordered locus">TDE_2668</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973266.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680713.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2668"/>
    <dbReference type="EnsemblBacteria" id="AAS13185">
        <property type="protein sequence ID" value="AAS13185"/>
        <property type="gene ID" value="TDE_2668"/>
    </dbReference>
    <dbReference type="GeneID" id="2741113"/>
    <dbReference type="KEGG" id="tde:TDE_2668"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2520"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_12"/>
    <dbReference type="OMA" id="SHPAGLI"/>
    <dbReference type="OrthoDB" id="861782at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="34"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="175"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS13185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="506" mass="55814" checksum="566525AB8930F687" modified="2004-07-05" version="1">MKEGLKKYLEREGSNAKLAMVAYLANLDQVASVYPEVASSIVKEIENQRSHLKLIASENYSSLAVQAAMGNLLTDKYAEGFPEHRYYGGCENVDAVEMAACEEACKIFGAEHAYVQPHSGADANIVAYWAILNAKVEEPFLKKFETVVDGKVKKMSLEGLSHEEWEELRHALGNQKLMGLDYYSGGHLTHGYVQNVSSKMFRTCSYTVNKETGELDYAEIEKRAMEEKPLILLAGYSAYPRKINFKKFREIADKCGAVLMVDMAHFAGLVAGKVFEGEYNPVLWADVVTTTTHKTLRGPRGAMILCKKEFAEFVDKGCPLVIGGPLPHVMAAKAVAFREASSKEYQDYAHKVRDNAVALAEECMKLGMKLQTNGTDNHLMLINVTKYGLNGRQAETAMSECGVTLNRNSLPFDPNGPWWTSGLRVGTPAVTSLGMGKPEMKQIASIIDRVLKASKPGVTKSGAPSKANVVVDPAVKAEIQKEVDALLHKFVLYPELDLDYLKSVYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JG3</accession>
    <name>Q73JG3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_M15_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973210.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2612"/>
    <dbReference type="EnsemblBacteria" id="AAS13129">
        <property type="protein sequence ID" value="AAS13129"/>
        <property type="gene ID" value="TDE_2612"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2612"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2469"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_700083_0_0_12"/>
    <dbReference type="OMA" id="DNMHFEY"/>
    <dbReference type="OrthoDB" id="1915613at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039561">
        <property type="entry name" value="Peptidase_M15C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13539">
        <property type="entry name" value="Peptidase_M15_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M15_4" evidence="2">
        <location>
            <begin position="217"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="390" mass="46531" checksum="CA98C6964EA77909" modified="2004-07-05" version="1">MQTVLNNFKQLLFILFFIGNLSIVPCENRDKLAAFNVNLDNPWLSLKAIQTAYPDLVKNISFDSELNDWFITIRNQNLYWADGRLLPKKDIQNRQKWAPIISYFYSDEVQNPKDFSEELISALKPESLIKNRKAAPPPNYTFFMLLFNGKNRNEIIKQIRRSRFLGYDVWVHQRVVEPLRRVQTKIYEAQKTNTEVKKFLKELNQCWSFNWRVIADSGKLSNHSWGSAIDLLPANYKTKKIYWFWEAARNDYWMKIMPYRRWIPPKAVIEAFESEGFIWGGKWTLWDNMHFEYRPELLYIRNFVLKAEFNEFIAQDTQGLYQTPQIEPEKQISQRLADIFKMAELIKFTSSFSHNILSFYGISATEEDKFEKEENIEEPQEPKYLEEMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JH8</accession>
    <name>Q73JH8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">rpe</name>
        <name evidence="15" type="ordered locus">TDE_2597</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973195.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957271.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2597"/>
    <dbReference type="EnsemblBacteria" id="AAS13114">
        <property type="protein sequence ID" value="AAS13114"/>
        <property type="gene ID" value="TDE_2597"/>
    </dbReference>
    <dbReference type="GeneID" id="2741301"/>
    <dbReference type="KEGG" id="tde:TDE_2597"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2455"/>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_12"/>
    <dbReference type="OMA" id="WLQVDGG"/>
    <dbReference type="OrthoDB" id="1697639at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AAS13114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="209" mass="22593" checksum="BC0C01570D855C70" modified="2004-07-05" version="1">MDRCFKLSPSLLSADFSKLGEELAFIEKHGGDWVHIDVMDGQFVPNLTFGAPVVKSIRPCSKLVFDVHLMVNNPENLVSAFADAGADYFTFHAEASIHADRLIADIRSHGMKAGVSIVPSTPVGILEEIAPLADLILVMSVNPGFGGQKLIPYCLEKVKRLRSLREEKNYNYLISVDGGIDSKNVGSVIDAGADVIVSGSAFFSGDLRI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JJ8</accession>
    <name>RPOC_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="1">RNAP subunit beta'</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoC</name>
        <name type="ordered locus">TDE_2420</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973019.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680359.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JJ8"/>
    <dbReference type="SMR" id="Q73JJ8"/>
    <dbReference type="STRING" id="243275.TDE_2420"/>
    <dbReference type="PRIDE" id="Q73JJ8"/>
    <dbReference type="EnsemblBacteria" id="AAS12938">
        <property type="protein sequence ID" value="AAS12938"/>
        <property type="gene ID" value="TDE_2420"/>
    </dbReference>
    <dbReference type="GeneID" id="2739845"/>
    <dbReference type="KEGG" id="tde:TDE_2420"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2287"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_3_1_12"/>
    <dbReference type="OMA" id="YRNIRVE"/>
    <dbReference type="OrthoDB" id="4421at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000067822" description="DNA-directed RNA polymerase subunit beta'">
        <location>
            <begin position="1"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="783"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="857"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="864"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="867"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <sequence length="1424" mass="160037" checksum="BC2778C13F3E30BC" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JL3</accession>
    <name>Q73JL3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PmbA_TldD_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973004.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680338.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73JL3"/>
    <dbReference type="STRING" id="243275.TDE_2405"/>
    <dbReference type="EnsemblBacteria" id="AAS12923">
        <property type="protein sequence ID" value="AAS12923"/>
        <property type="gene ID" value="TDE_2405"/>
    </dbReference>
    <dbReference type="GeneID" id="2740707"/>
    <dbReference type="KEGG" id="tde:TDE_2405"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2271"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050371_0_0_12"/>
    <dbReference type="OrthoDB" id="958356at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="1">
        <location>
            <begin position="219"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="444" mass="49580" checksum="9191EE766F60F1AB" modified="2004-07-05" version="1">MKMSFKEYFESIADFMLSELLEGEKISISFSGEKSYFMRFSKAKVRQNGMVDQGYFSCTFWKKNRTHNFSFGIQMSMEKDKRMAAEALQEARDSIMLLPEDKYQSIPEASQTSSAIYTGKLLPEDKIPETILSPVKDLDFAGLYSQGVICKGVITSAGASHWFQTETFVLDYSVWLENGRGIKSLYSGTEWSDAQYKLKIEQARKGLEVLHTPQKKLAPGKYKAFISADALLDVTDFFSWNGFSERSMQQGSSAYLALKEGREHFSDKFNLTQDFSLGLEPAFNSNGELAPEKLSIIEKGKLKNTLVSLRTETQYGVKSNGAPLSESMRSIVIGTGNLNEADAVKELGTGIYISNFNYLNWSDTSSARVTGMTRFACLWVEDGKIVAPIADMRWDESLYNMFGENLLAVTKESRIFANTGTYGSRSTGGASLPGILVKDFNCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JN5</accession>
    <name>Q73JN5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Shikimate kinase</fullName>
            <shortName evidence="2">SK</shortName>
            <ecNumber evidence="2">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">aroK</name>
        <name evidence="3" type="ordered locus">TDE_2447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973046.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680396.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2447"/>
    <dbReference type="EnsemblBacteria" id="AAS12965">
        <property type="protein sequence ID" value="AAS12965"/>
        <property type="gene ID" value="TDE_2447"/>
    </dbReference>
    <dbReference type="GeneID" id="2739632"/>
    <dbReference type="KEGG" id="tde:TDE_2447"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2315"/>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057607_4_2_12"/>
    <dbReference type="OMA" id="YCECENA"/>
    <dbReference type="OrthoDB" id="1392851at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="202" mass="22972" checksum="E509ECEFC6687ABF" modified="2004-07-05" version="1">MIIFLIGMSRAGKTETGRALSKKLKAPFVDTDSYMEEVYGKTIRELYKAHGEKKFRLKEFECLNKIIEKIIEKFSSCSNDKNAIYCECENAVHCDDVNAIVSTGGGYAENEAIIKKLKDFPRIILIDTAPAEIFYRIKTSAYKKGFYPAFLGENIKNEKDAEDRFFSIYERRIKIYKALASFSINPKGLSPDETADKIISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JP6</accession>
    <name>Q73JP6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2449"/>
    <dbReference type="EnsemblBacteria" id="AAS12967">
        <property type="protein sequence ID" value="AAS12967"/>
        <property type="gene ID" value="TDE_2449"/>
    </dbReference>
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    <dbReference type="KEGG" id="tde:TDE_2449"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2317"/>
    <dbReference type="eggNOG" id="COG2078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048702_0_0_12"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
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        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="300"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="468" mass="52050" checksum="E0AAD2B726898385" modified="2004-07-05" version="1">MRKKELCSKDTNLRAAYITPHPPIIIPEIGRGEEKKIASTSKALKTISKEVKQIEPETIIIITPHAKMHRGAVTINTAPVIEGTMAQFGCPDLRFSAKNDERIVKEIIKKCKKTGFPYAAVDMNLDHGSFVPLYFISSEFSNFSLVHINYGIMLSAMLEEFGSILSDIIEEKKCKSVFIASGDLSHRLLSTGPYGFAPEGPKFDKEFVRIIEKGSLSEFADIPPLLTERAGECGLNSFLILSGLLSCYKHSQELLSYEGPFGVGYGVARFKVKSIRQPEDEDLEIVFKEKKKKFILPDSQTNDPYINLARRSIIYYLKHNKFLKPKNTDGIQSGKAGVFVCLKKKGELRGCIGTILPTKSRISEEIIKNAVSAALNDPRFPPVDLSEMDEIVCSVDILAEPEEIKSISDLDVKRFGVIVSSGSRTGLLLPNLEGIDSVGMQVAIALQKGGISPEEPYRMYRFEVIRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JS5</accession>
    <name>Q73JS5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973083.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675942.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2485"/>
    <dbReference type="DNASU" id="2741458"/>
    <dbReference type="EnsemblBacteria" id="AAS13002">
        <property type="protein sequence ID" value="AAS13002"/>
        <property type="gene ID" value="TDE_2485"/>
    </dbReference>
    <dbReference type="GeneID" id="2741458"/>
    <dbReference type="KEGG" id="tde:TDE_2485"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2351"/>
    <dbReference type="eggNOG" id="COG4260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042784_0_0_12"/>
    <dbReference type="OMA" id="QFASNKM"/>
    <dbReference type="OrthoDB" id="886332at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band_7_1" evidence="2">
        <location>
            <begin position="56"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="zinc_ribbon_2" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="406" mass="43411" checksum="F569846A091137CB" modified="2004-07-05" version="1">MGLISAAVGAVGGGLADQWLEVIEAGDMGEGIVLAKGVAVRTDKRNTNKKGSSDVVSNGSIIHVNQNQFMMLVDGGKIVDYTAEPGYFKVENSASPSLFGGQFGDALKETFSRFKFGGTTPMKQEVFYVNLQEIKGIKFGTPNPLQYFDNFYNAELFLRTFGNYSIKITDPIKFFKEACPRDAENVHIDEINEQYLSEFLEALQAAISQMSMEGERISFIPSKGTVLSKHMSEILDDSWKELRGMEVLSVGIASISYDDESKELINMRNKGAMLGDPGVREGYVQGSIARGMEAAGSNQAGAGMAFMGMGMGMNAAGGFMGQASQTNMQQMQMNQAAQRAAQGAGQQQGAGAKAAGEWFCTECGHKNTGKFCAECGTPKPQGSGCPSCGAELKAGAKFCPECGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JY0</accession>
    <name>Q73JY0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973131.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680500.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2533"/>
    <dbReference type="EnsemblBacteria" id="AAS13050">
        <property type="protein sequence ID" value="AAS13050"/>
        <property type="gene ID" value="TDE_2533"/>
    </dbReference>
    <dbReference type="GeneID" id="2739045"/>
    <dbReference type="KEGG" id="tde:TDE_2533"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2396"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709680_0_0_12"/>
    <dbReference type="OMA" id="WNYPKRN"/>
    <dbReference type="OrthoDB" id="1074445at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS13050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="398" mass="43363" checksum="84D694A21C7DDEB9" modified="2004-07-05" version="1">MKDLRKRTFNVSGLSFLVYSLSSIAISICLVNIKRDLNFSLTEAGLFGMLCAIEQMIILFISPIFAAKFGKIKVLRTALLILTAGLFFFSKSINFFTALLSALCMGLGVANMEALLTPIVNDLYPNDTGAKMNMMHAFWPLGTCSGLIGFGYLLSIGINWRYIYIGLSIFALLICFSYPSSKKIKLPPSDGSKAAFKEIFSLPSFWLFGLSLFFAGGAEGAFAFWSATLIQLYLKASAFYAGIVTASFALGMFIGRSLNSKVLKKVSIQKAIIVSSIASFIVSLLFVFVNSLFGLAVFLFCMGLCLACLWPTIQSFAAVILPVDATALMIFLSCFGVPGYSTASFIMGIVGDKYDLFIAFITVVPVFLILVPILFIMGCKLSGSPKLKPLREKNEFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K10</accession>
    <name>Q73K10_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-8X methylmutase</fullName>
            <ecNumber evidence="6">5.4.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cobH</name>
        <name evidence="6" type="ordered locus">TDE_2555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <dbReference type="EC" id="5.4.1.2" evidence="6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973153.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680526.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2555"/>
    <dbReference type="EnsemblBacteria" id="AAS13072">
        <property type="protein sequence ID" value="AAS13072"/>
        <property type="gene ID" value="TDE_2555"/>
    </dbReference>
    <dbReference type="GeneID" id="2739920"/>
    <dbReference type="KEGG" id="tde:TDE_2555"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2415"/>
    <dbReference type="eggNOG" id="COG2082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084703_1_1_12"/>
    <dbReference type="OMA" id="GAPIFCD"/>
    <dbReference type="OrthoDB" id="1812068at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="8"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS13072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="207" mass="22939" checksum="C7AB2EE8594E21C0" modified="2004-07-05" version="1">MYIKKPMEIENKSMDIIEESMKDVAFTEEEKIIAKRMIHTTGDVEYRKIIVFQNNFIESAKRALQKGITIFTDTKMVLTGINKPALSKTENKLLCLIDDERVFKMSKEDGITRSSAAVDLAVQEGAKAFVIGNAPTALFRLLELCEEKKVSPEFIIGVPVGFVGAAESKEALRSKPFPQISTVGTKGGSNVAASIINALLYMMVERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K24</accession>
    <name>Q73K24_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973165.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680551.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2567"/>
    <dbReference type="EnsemblBacteria" id="AAS13084">
        <property type="protein sequence ID" value="AAS13084"/>
        <property type="gene ID" value="TDE_2567"/>
    </dbReference>
    <dbReference type="GeneID" id="2739932"/>
    <dbReference type="KEGG" id="tde:TDE_2567"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2426"/>
    <dbReference type="eggNOG" id="ENOG5033WJP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_952966_0_0_12"/>
    <dbReference type="OMA" id="YTMDGEA"/>
    <dbReference type="OrthoDB" id="1193661at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284563" evidence="1">
        <location>
            <begin position="23"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="292" mass="32254" checksum="EA0F4FD73AC50ADF" modified="2004-07-05" version="1">MKPIKKLFFLVMFVFVSFSAFAFDEGFTLGLRSNFSGSYTDPHINEADKEYLGAAFMRGMAGFIMNGEAELTYIFDSKRYFNYTNNNIFGGLGLAFNLGVGQGFSGQISGQYNASLGKNIEVYCRVYMTPVVTFGTTVKALLFKNRLAVGLGLGGKMLADPQPTYELYTNLTDEEAEMLNNGGTGPDFFPETGTLYIPGSMTRKMNPLGLTLKAVIDYNIPLIEKMNVTMGSYASYTIYKPGYVSLPKKIAKAAIENGKLKGIDVNFERDSIKSFFMNSLDFGISLGLLFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K30</accession>
    <name>Q73K30_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973185.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680574.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2587"/>
    <dbReference type="EnsemblBacteria" id="AAS13104">
        <property type="protein sequence ID" value="AAS13104"/>
        <property type="gene ID" value="TDE_2587"/>
    </dbReference>
    <dbReference type="GeneID" id="2741291"/>
    <dbReference type="KEGG" id="tde:TDE_2587"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2446"/>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058239_0_0_12"/>
    <dbReference type="OMA" id="VCHWKSK"/>
    <dbReference type="OrthoDB" id="1387978at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19580">
        <property type="entry name" value="Exo_endo_phos_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285804" evidence="1">
        <location>
            <begin position="23"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="41"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="339" mass="38579" checksum="8EEE8A684CCF6905" modified="2004-07-05" version="1">MKKLRKILTLSIFICFCFILCACTGCTNVFRLQNIGKDEISIVSYNAQTFFDAVEDGREFKEFKGSKTKWSKEKYAERLFRLKEAVNLSCLALGLGEKAIPDILVLQEIESRAVIDDFCKILPMNNSYKYAVFIPPQNGGAFSTALLSKFPITETKVFNVYSGKRSLRPLIETRIRIGNSTGDNELVLLNVHWKSKVGNSDTDSIRRQQEEQAYKRLKELKASEPQTPFIICGDFNQTLEEFSLLSEFDNCWNIEAYRAAAQEGSQPAGSYFYKESWEGIDHFFYSDNLSDGKNFDLSFFCVINLKPLTDTSGKPDKYSVYSGKGYSDHLPIGIILKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K32</accession>
    <name>Q73K32_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyl-accepting transducer domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2585</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973183.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680571.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2585"/>
    <dbReference type="EnsemblBacteria" id="AAS13102">
        <property type="protein sequence ID" value="AAS13102"/>
        <property type="gene ID" value="TDE_2585"/>
    </dbReference>
    <dbReference type="GeneID" id="2741289"/>
    <dbReference type="KEGG" id="tde:TDE_2585"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2444"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020312_0_0_12"/>
    <dbReference type="OMA" id="RIENNIT"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="492"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS13102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="775" mass="86761" checksum="BD017D9D82B2BCC8" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K78</accession>
    <name>DXR_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="1">DXP reductoisomerase</shortName>
            <ecNumber evidence="1">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dxr</name>
        <name type="ordered locus">TDE_2342</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972941.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680260.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73K78"/>
    <dbReference type="SMR" id="Q73K78"/>
    <dbReference type="STRING" id="243275.TDE_2342"/>
    <dbReference type="EnsemblBacteria" id="AAS12860">
        <property type="protein sequence ID" value="AAS12860"/>
        <property type="gene ID" value="TDE_2342"/>
    </dbReference>
    <dbReference type="GeneID" id="2739437"/>
    <dbReference type="KEGG" id="tde:TDE_2342"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2210"/>
    <dbReference type="eggNOG" id="COG0743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035714_4_0_12"/>
    <dbReference type="OMA" id="PIDSEHF"/>
    <dbReference type="OrthoDB" id="1200722at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000163726" description="1-deoxy-D-xylulose 5-phosphate reductoisomerase">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <sequence length="381" mass="41592" checksum="E46ED53B54876974" modified="2004-07-05" version="1">MGRKRVVVLGAGGSIGKNSLEIIRRFPDRFELAGFSVHSNSGFAKTLLAEFTDAQFVSTKKKNSNLKHEIDEEAVRRLIEKSKADIVINGIAGSAGLKASVEVIKSGLDLALANKETIVEAGELIFQDAEKSGSTIIPVDSEHAAIFQLINAHKKGNIEKIIITASGGPFLNTPREKLSTIKLEDALKHPTWKMGGKISIDSASLANKALEVIEAVKLFSFPPEKIEVTVHPQSIIHSMVQCKNGEIFAQASPPDMKNPILNALSFPKMPESFLKPLDFSQIIKLEFMPPRTDDFPMLALGFEAAGKGGAYPIAFNVANEEAVDAFIKGKIGFTDLADITQEVLNSDWTMKPSSYEEVYDYENRARAIALARILDRVNGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KB9</accession>
    <name>Q73KB9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Trypsin domain/PDZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972900.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674333.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2300"/>
    <dbReference type="MEROPS" id="S01.525"/>
    <dbReference type="EnsemblBacteria" id="AAS12819">
        <property type="protein sequence ID" value="AAS12819"/>
        <property type="gene ID" value="TDE_2300"/>
    </dbReference>
    <dbReference type="GeneID" id="2740265"/>
    <dbReference type="KEGG" id="tde:TDE_2300"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2170"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_0_12"/>
    <dbReference type="OMA" id="IIGINRQ"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="288"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="385"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="493" mass="53474" checksum="8BF1FC73403A62D0" modified="2004-07-05" version="1">MRKLKNPLSAMAGILLIMLVSVVFLSARCSSNPENASTVYADPGLKTELSKESVSALESLQKANRELTSMILPSVVTLDVVETRKVQNNIDGFPWFFFNRPQDQKDGQGEREYEAEGMGSGVIVRKTGKTYYVLTNQHVTGNAKTISVMLYNGDKVQGKLIGSDQRKDVALVSFDYDKDLRVAVLGDSNTVQVGDLTYAIGAPMGYVSTVTSGIVSAVGRSGGPNRNNINDFIQTDAAINQGNSGGPLVNIYGEVIGINNWIVSSSGGSQGLAFSIPINNLKKAIDDFITSGEIKYGWLGVQLLEINDKFRESLNLKDIEGAFAGQVFLGSPADKGGIKPGDYITEVNSTKVKSVDDILRVIADLKPGESSSFKILRKGKEISATVKIEERDEKNVADSSKLWPGFVPSPLTEEIIKQLELKKGQNGVLVTSLQAKSPAAVMSLQPGDLIVKVNGKDVKDVLSFYDELSNAKGEIWFDFIREGHNLVTPKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KC1</accession>
    <name>Q73KC1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972897.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680214.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2297"/>
    <dbReference type="EnsemblBacteria" id="AAS12816">
        <property type="protein sequence ID" value="AAS12816"/>
        <property type="gene ID" value="TDE_2297"/>
    </dbReference>
    <dbReference type="GeneID" id="2740262"/>
    <dbReference type="KEGG" id="tde:TDE_2297"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2167"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229445_0_0_12"/>
    <dbReference type="OMA" id="MYDLAEF"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011716">
        <property type="entry name" value="TPR-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07720">
        <property type="entry name" value="TPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="226" mass="26096" checksum="0977ABE1633E585D" modified="2004-07-05" version="1">MYSELKEGVNLYNKKDYQEALVFFLSVSTEDVLIKIEINYYIGLIYSRLSEYEQALEYLEQVVTASKDIAKVYQCRLILAFIYANTGRTRLAEFELSKLIEAGYESVQVFSSLAYVYYEHHEIEKAIDYYEKALKTAPENSTALNGLAYILAETDRDLTRSLLLCKKAVEKQPENPAYLDSMALIYHKMNLPSEAKSYITRAKEKLPDNKIILKHFEMISSDAREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KD7</accession>
    <name>Q73KD7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972881.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680169.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2281"/>
    <dbReference type="EnsemblBacteria" id="AAS12800">
        <property type="protein sequence ID" value="AAS12800"/>
        <property type="gene ID" value="TDE_2281"/>
    </dbReference>
    <dbReference type="GeneID" id="2740031"/>
    <dbReference type="KEGG" id="tde:TDE_2281"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2151"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_767138_0_0_12"/>
    <dbReference type="OMA" id="YPRIARF"/>
    <dbReference type="OrthoDB" id="2063919at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="307"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="357" mass="39730" checksum="436E85CF09AB38F2" modified="2004-07-05" version="1">MASKIGIKLADGTFFPILDESALSEQSLELTTVRDDQESVQINLFKQVDGAEPEYIGSLIVEDISTGRAGDPTINLKIKLDEEKNLSAEAVDEGSGSHQSLRVSLKNLDEASLEGMDFDFASLDSSSGFTSGDDDYFIKESDDLSFDESLESQADSQLYDNEEKPEKKKKMPLWLIIIIIILCITALVFAILLLTKKMPFADKDKIASVPEKVEQVQESKKDVNATTSNVPKENTAEKAAAEAKRKAEEEAKQKAEAEAKKKAEEEAKQKAEAQAKKKAEEEAKQKAEAKKKAETQQKSNTNSNGAVRYKIKWGDTLWDLSETYYKTPWLYKKIADYNKIKNPNLIIAGTYIDIPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KF8</accession>
    <name>Q73KF8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972860.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12779">
        <property type="protein sequence ID" value="AAS12779"/>
        <property type="gene ID" value="TDE_2260"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2260"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2133"/>
    <dbReference type="HOGENOM" id="CLU_3105030_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="51" mass="5560" checksum="E2FABFF788860FA7" modified="2004-07-05" version="1">METPFLKAKGLVFLIELSQSVGHADYCFAKLSEAQCLAGVAVFYVSKFVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KN3</accession>
    <name>Q73KN3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972785.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680031.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2184"/>
    <dbReference type="EnsemblBacteria" id="AAS12704">
        <property type="protein sequence ID" value="AAS12704"/>
        <property type="gene ID" value="TDE_2184"/>
    </dbReference>
    <dbReference type="GeneID" id="2740206"/>
    <dbReference type="KEGG" id="tde:TDE_2184"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2061"/>
    <dbReference type="eggNOG" id="ENOG5034689">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019092_0_0_12"/>
    <dbReference type="OMA" id="RISAWDY"/>
    <dbReference type="OrthoDB" id="772370at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284909" evidence="2">
        <location>
            <begin position="21"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="726" mass="80377" checksum="7B7003AD4DBA0344" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KS1</accession>
    <name>Q73KS1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972747.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679981.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2146"/>
    <dbReference type="ESTHER" id="trede-q73ks1">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12666">
        <property type="protein sequence ID" value="AAS12666"/>
        <property type="gene ID" value="TDE_2146"/>
    </dbReference>
    <dbReference type="GeneID" id="2739132"/>
    <dbReference type="KEGG" id="tde:TDE_2146"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2027"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026209_1_0_12"/>
    <dbReference type="OMA" id="NRTAFDW"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="24"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="304" mass="34177" checksum="53CE25039B140DA9" modified="2004-07-05" version="1">MQTIYQTMSDGSAVAVHQWLPKKKPKAVIHIVHGMAEHALRYADFAEDACTKGFTVFASDHRGHGKTCGKIMLKGYLADKDGFKRVVEDQKEINDEIQKIYQDIPIIILGHSFGSFITQNYIENYGKTVKAAILVGSAGPNPMLKIAGLAAGLNKLFSGRKKPSKFMDKLSFGAYNKTVDSPKTNFDWLSRDEKEVKKYIDDEFCGFVCTVGFYQDLIKGLKQTHTSTEMIKIPNELPILITSGDRDPVSSLGKSVKKLYDIYKANGISDLNLKLYEGARHEILNETNKEEVKADIFEWIEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KT8</accession>
    <name>Q73KT8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972730.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12649">
        <property type="protein sequence ID" value="AAS12649"/>
        <property type="gene ID" value="TDE_2129"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2129"/>
    <dbReference type="HOGENOM" id="CLU_3405980_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3465" checksum="1CCEC9E3E498CC2E" modified="2004-07-05" version="1">MPLIISKAQIKMSGDILGSCFKLFYLRPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KU9</accession>
    <name>Q73KU9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2118</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972719.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679930.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2118"/>
    <dbReference type="EnsemblBacteria" id="AAS12638">
        <property type="protein sequence ID" value="AAS12638"/>
        <property type="gene ID" value="TDE_2118"/>
    </dbReference>
    <dbReference type="GeneID" id="2739377"/>
    <dbReference type="KEGG" id="tde:TDE_2118"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2001"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015760_0_0_12"/>
    <dbReference type="OMA" id="GHTMQYH"/>
    <dbReference type="OrthoDB" id="217468at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="6">
        <location>
            <begin position="4"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="643"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="703" mass="79749" checksum="75AA8F10D8044664" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L49</accession>
    <name>Q73L49_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972619.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679783.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2016"/>
    <dbReference type="EnsemblBacteria" id="AAS12530">
        <property type="protein sequence ID" value="AAS12530"/>
        <property type="gene ID" value="TDE_2016"/>
    </dbReference>
    <dbReference type="GeneID" id="2740363"/>
    <dbReference type="KEGG" id="tde:TDE_2016"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1904"/>
    <dbReference type="eggNOG" id="ENOG5031D8Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_785117_0_0_12"/>
    <dbReference type="OrthoDB" id="1924552at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="356" mass="41656" checksum="3C87AFB28363E33F" modified="2004-07-05" version="1">MKKLYILLMVFALFFSCKKSDEKKLSGTVSKKTEVIISNTEKEISKQVADFDKDKFYERSFLLDWNSFIPKGRNSNFLPSSYSYTKHGVKYKTLIIWKVYTEYGMDKLLQSYAEGGEMGGQSYTKDNTGKKLLVAGYKYDENGCLVSSIEPILYGEGGQMETLYKYDSYHRCTASYSRYIPEIDLIPYSAEYDQKAENCIITQEGSKEYTPINKTNDVLECKSYYVHSDGKKDLISTIKEGKTEDYFFYNNQKVFLINNRLEEIKDENGVWKFLYNENEQILEAVQTANNKVKEKFFDAKYKNGKLIESKYDDGNSVIKTVYKKYDSFGNWLEADIHYNNDENCSFTIFRDFEYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L59</accession>
    <name>Q73L59_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Daugherty S.C."/>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
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        <property type="gene ID" value="TDE_1985"/>
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    <dbReference type="KEGG" id="tde:TDE_1985"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
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        <location>
            <begin position="85"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="924" mass="103806" checksum="73EA09B00F2C39B1" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L90</accession>
    <name>Q73L90_TREDE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="protein sequence ID" value="AAS12489"/>
        <property type="gene ID" value="TDE_1975"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1975"/>
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    <dbReference type="Proteomes" id="UP000008212">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="35" mass="4510" checksum="7F68F5A3C88869EE" modified="2004-07-05" version="1">MYHNDTILKRAAKDFYTFFWFIFSFYFNSKKQKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LC0</accession>
    <name>Q73LC0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ordered locus">TDE_1945</name>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1945"/>
    <dbReference type="EnsemblBacteria" id="AAS12459">
        <property type="protein sequence ID" value="AAS12459"/>
        <property type="gene ID" value="TDE_1945"/>
    </dbReference>
    <dbReference type="GeneID" id="2740185"/>
    <dbReference type="KEGG" id="tde:TDE_1945"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1837"/>
    <dbReference type="eggNOG" id="ENOG5034B8J">
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    <dbReference type="OrthoDB" id="1761965at2"/>
    <dbReference type="Proteomes" id="UP000008212">
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
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    </dbReference>
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        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="108" mass="12496" checksum="9167F2A9276E750B" modified="2004-07-05" version="1">MHYKVLFRIEKFNLIDKLKHKITNYKRYCEELGDTAEIEVVFAGDVVKYFESLENDFTDSGLDIALCHNALTGQNMPDINYKNIRTVRAGIGEIISRKAEGFIEYTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LD1</accession>
    <name>Q73LD1_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1934</name>
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    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
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                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1934"/>
    <dbReference type="EnsemblBacteria" id="AAS12448">
        <property type="protein sequence ID" value="AAS12448"/>
        <property type="gene ID" value="TDE_1934"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1934"/>
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    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="36" mass="4274" checksum="E95CF735C6A6F36D" modified="2004-07-05" version="1">MLKRTKVTEKELWLLAEKCTSVYIFQLRVLPYGKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LG5</accession>
    <name>Q73LG5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1899</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="243275.TDE_1899"/>
    <dbReference type="EnsemblBacteria" id="AAS12413">
        <property type="protein sequence ID" value="AAS12413"/>
        <property type="gene ID" value="TDE_1899"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1899"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1798"/>
    <dbReference type="HOGENOM" id="CLU_3159001_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="48" mass="5723" checksum="4783FC9EC2AEC625" modified="2004-07-05" version="1">MGAWDELDIIIFRISFTSLKKIAAPNVYIVYTVYKHLSRPKKKFYKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LH9</accession>
    <name>Q73LH9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972487.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1884"/>
    <dbReference type="EnsemblBacteria" id="AAS12398">
        <property type="protein sequence ID" value="AAS12398"/>
        <property type="gene ID" value="TDE_1884"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1884"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1786"/>
    <dbReference type="eggNOG" id="ENOG5033Y0K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_729447_0_0_12"/>
    <dbReference type="OMA" id="FLINIMP"/>
    <dbReference type="OrthoDB" id="1149084at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="327" mass="36798" checksum="FD4ABE817B185475" modified="2004-07-05" version="1">MFTNPAIFPFLTKRWSAGKIALHANEDSFGGFGSIFASEKLKTLAEYLYKGDSKYFDFSATGPLALSLADRNFAVGLFNRTVFHADVQNTIMKKLLIGEELLVTGGYGICLYDDDVNKVSLGFQMKGFFQTFSYALNKSKADMTLAVNSGLKDLNIVLASGIGLDAGFLYKYDNYFFLGITCKDAYTPVFLTPYNNFSDYKKAITAGKTQYKTLLPNLSAGIGSMPVFDDVWTTVSSWSFYLDYQNILEPIFNKNRSPLLNLAFGTEIVFHKVLSFRLGMHELYPHLGVGLDFTYFQIDFSAFLKELGNKPWEKQKIGLDFAFSFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LJ5</accession>
    <name>Q73LJ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972471.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1867"/>
    <dbReference type="EnsemblBacteria" id="AAS12382">
        <property type="protein sequence ID" value="AAS12382"/>
        <property type="gene ID" value="TDE_1867"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1867"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1771"/>
    <dbReference type="HOGENOM" id="CLU_211699_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="54" mass="6404" checksum="E8FDB3B3407BB5B3" modified="2004-07-05" version="1">MSFWKDKILFQLYKEEKDTSNIKKIKKLILMITHRSSYDKIADGVFKIGKRGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LM1</accession>
    <name>Q73LM1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1801</name>
        <name evidence="2" type="ordered locus">TDE_1841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405</strain>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972405.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972445.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010692226.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1801"/>
    <dbReference type="EnsemblBacteria" id="AAS12316">
        <property type="protein sequence ID" value="AAS12316"/>
        <property type="gene ID" value="TDE_1801"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12356">
        <property type="protein sequence ID" value="AAS12356"/>
        <property type="gene ID" value="TDE_1841"/>
    </dbReference>
    <dbReference type="GeneID" id="2740503"/>
    <dbReference type="KEGG" id="tde:TDE_1801"/>
    <dbReference type="KEGG" id="tde:TDE_1841"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1713"/>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186687_0_0_12"/>
    <dbReference type="OrthoDB" id="1938968at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="96" mass="11621" checksum="2ACD850199D524C8" modified="2004-07-05" version="1">MTFDWNNEKNIMLKRDRNISFERIIIAIEQDSLLDILEHPNKEKYPNQILLLIEIDRYVYVVPCVLENDVCFLKTIFPSRKYTAKYLDFKGEENEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LN0</accession>
    <name>Q73LN0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1796</name>
        <name evidence="3" type="ordered locus">TDE_1832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405</strain>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972400.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972436.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002683251.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1796"/>
    <dbReference type="EnsemblBacteria" id="AAS12311">
        <property type="protein sequence ID" value="AAS12311"/>
        <property type="gene ID" value="TDE_1796"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12347">
        <property type="protein sequence ID" value="AAS12347"/>
        <property type="gene ID" value="TDE_1832"/>
    </dbReference>
    <dbReference type="GeneID" id="2740494"/>
    <dbReference type="KEGG" id="tde:TDE_1796"/>
    <dbReference type="KEGG" id="tde:TDE_1832"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1709"/>
    <dbReference type="eggNOG" id="COG2859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077423_0_0_12"/>
    <dbReference type="OMA" id="YYYTKLA"/>
    <dbReference type="OrthoDB" id="1108674at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016907">
        <property type="entry name" value="UCP029033"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029033">
        <property type="entry name" value="UCP029033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="249" mass="28986" checksum="97344001D4EF6F27" modified="2004-07-05" version="1">MEIRNESKIEIIKLSMILFTIIISLIVLSKTFLERNKESEVIQVTGLGTKDFESDLIVWSGSFSQTDIDLKNAYERLQLDQNKIIDFLKKRNVSTNEYLFSAVVIDKEYETIYDMDKNQKRLFKGYRLMQDIKIESNEVEKIETISREITELINMGVEFYSSKPQYYYTKLTELKKELIEYATENAKTRAETIASKSGFKLGRLKNANMGVFQIIARNSNEDYSWEGTFNTTSKQKTATITMKLQFGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M54</accession>
    <name>Q73M54_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972261.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679349.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1656"/>
    <dbReference type="EnsemblBacteria" id="AAS12172">
        <property type="protein sequence ID" value="AAS12172"/>
        <property type="gene ID" value="TDE_1656"/>
    </dbReference>
    <dbReference type="GeneID" id="2738997"/>
    <dbReference type="KEGG" id="tde:TDE_1656"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1583"/>
    <dbReference type="eggNOG" id="ENOG5031C4W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_492532_0_0_12"/>
    <dbReference type="OMA" id="GKESIIR"/>
    <dbReference type="OrthoDB" id="201840at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011716">
        <property type="entry name" value="TPR-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07720">
        <property type="entry name" value="TPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284597" evidence="2">
        <location>
            <begin position="22"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="506"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="553" mass="62326" checksum="DE66AB7D96281831" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MD9</accession>
    <name>Q73MD9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972175.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1569"/>
    <dbReference type="EnsemblBacteria" id="AAS12086">
        <property type="protein sequence ID" value="AAS12086"/>
        <property type="gene ID" value="TDE_1569"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1569"/>
    <dbReference type="HOGENOM" id="CLU_3359076_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="36" mass="4427" checksum="9994F9ABF41309D8" modified="2004-07-05" version="1">MPTLVYFYILCNNKNYKKALGFLRVRCLLRPFKQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MF5</accession>
    <name>Q73MF5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972159.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679213.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1553"/>
    <dbReference type="EnsemblBacteria" id="AAS12070">
        <property type="protein sequence ID" value="AAS12070"/>
        <property type="gene ID" value="TDE_1553"/>
    </dbReference>
    <dbReference type="GeneID" id="2739303"/>
    <dbReference type="KEGG" id="tde:TDE_1553"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1489"/>
    <dbReference type="eggNOG" id="ENOG503133W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1255494_0_0_12"/>
    <dbReference type="OrthoDB" id="2113863at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="220" mass="26437" checksum="85309F8FCFE970AD" modified="2004-07-05" version="1">MEKENAKQQLKSNIKFSVILIVLLCLNIYTVFQIKKSQEEVKNITKLLEHMEKNILERIEYNRDEINTKIEISTENILNEIKETEKLLKLQGKETQLQLKNLFSSQKRINENDKKKDLRLIYAEGILEKRETEAYNLLKEKRYAAAYKIYKEIKESDPERLSSRYYGVYSLFYSNEMDKENYDYILEEIEYLRKNGMEESSFKIIENFIKREKAINDEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MH4</accession>
    <name>Q73MH4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972140.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1534"/>
    <dbReference type="EnsemblBacteria" id="AAS12051">
        <property type="protein sequence ID" value="AAS12051"/>
        <property type="gene ID" value="TDE_1534"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1534"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1471"/>
    <dbReference type="eggNOG" id="ENOG5032PTE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1634645_0_0_12"/>
    <dbReference type="OrthoDB" id="2122106at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="153" mass="16526" checksum="8D25C4243C381C60" modified="2004-07-05" version="1">MWTDKNNVEKINIDLDNSKTENACSIKQKDCYAVKSCATCGGCGFAGKNKERGLLAVSGNKITALNNSGRNLKKGDFVIVEINENQTRIQTLSSVIIPILLAFVFSLSSYLIFYTEKAAVGGLFLGLLTGTALAFLLKNKMGDRALPQVISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MJ2</accession>
    <name>Q73MJ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1516</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972122.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669030.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1516"/>
    <dbReference type="TCDB" id="3.A.1.122.8">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="TCDB" id="3.A.1.136.1">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12033">
        <property type="protein sequence ID" value="AAS12033"/>
        <property type="gene ID" value="TDE_1516"/>
    </dbReference>
    <dbReference type="GeneID" id="2739722"/>
    <dbReference type="KEGG" id="tde:TDE_1516"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1455"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="ADRANDW"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="230" mass="25625" checksum="BFA9D3A40EC9E175" modified="2004-07-05" version="1">MNILTLTEISKIYGDLKALDKINLTVEEGEWLSIMGPSGSGKTTLMNIIGCMDKPSLGKIDLAGQDISKLSSKELTIVRRDMIGLVFQQFHLVNYLTALENVMMAQYYHSLPDEKEALEALESVGLKERAKHLPNQLSGGEQQRVCIARALINHPKLLLADEPTGNLDEKNEKLVMEIFEKLHNAGSTIIVVTHDPEVADQAERMVVLEHGKIARIEKMSRVRPSRGENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MJ7</accession>
    <name>Q73MJ7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pathogen-specific surface antigen, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0423 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972117.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669021.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73MJ7"/>
    <dbReference type="STRING" id="243275.TDE_1511"/>
    <dbReference type="EnsemblBacteria" id="AAS12028">
        <property type="protein sequence ID" value="AAS12028"/>
        <property type="gene ID" value="TDE_1511"/>
    </dbReference>
    <dbReference type="GeneID" id="2739717"/>
    <dbReference type="KEGG" id="tde:TDE_1511"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1450"/>
    <dbReference type="eggNOG" id="COG3470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100963_0_0_12"/>
    <dbReference type="OMA" id="GRFWTEP"/>
    <dbReference type="OrthoDB" id="1456006at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018470">
        <property type="entry name" value="Metal-bd_Tp34-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038482">
        <property type="entry name" value="Tp34-type_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10634">
        <property type="entry name" value="Iron_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017018">
        <property type="entry name" value="Tp34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284956" evidence="4">
        <location>
            <begin position="21"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="208" mass="22693" checksum="16A4ED494B0C88E6" modified="2004-07-05" version="1">MKKTLSCIFALLAIAFVITSCEKKEAVQQAAKPAPTEEKTAAPKPHEEGAAGFDEFPIGDEQDAGILTVAGVYFQPVDMEPAGNSLSKNEADCHMEADISANEKGATLGYGAGDFVPYLHVKAYIQKVGSSKVQEVAFMPMNASDGPHYGANVKFEEGLGKYNIKFEIKAPGNDYLLHVDKETGVTGRFWTEPIVVEWKDFEWTGPQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MS2</accession>
    <name>Q73MS2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972041.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1435"/>
    <dbReference type="EnsemblBacteria" id="AAS11952">
        <property type="protein sequence ID" value="AAS11952"/>
        <property type="gene ID" value="TDE_1435"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1435"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1376"/>
    <dbReference type="eggNOG" id="COG1887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037413_0_0_12"/>
    <dbReference type="OMA" id="WDYNSEN"/>
    <dbReference type="OrthoDB" id="1159548at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047355">
        <property type="term" value="F:CDP-glycerol glycerophosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007554">
        <property type="entry name" value="Glycerophosphate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043148">
        <property type="entry name" value="TagF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04464">
        <property type="entry name" value="Glyphos_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="386" mass="44362" checksum="4DA4FA77AC02A098" modified="2004-07-05" version="1">MIGLITTLYFVAKTAFIKLKVAVYKDKAKGSGNKNTIVIYSEGKRYWNVFLPICNEFEEHQKELVFYTSSEDDPVFEQHYTYVKPEYIGKGNKAFARLNMLEADICLMTTPGLDVYQLKRSKHVRHYSHILHALDDATSYRLFGLDYFDSVLLSGEYQVKGIRELESLRNLPPKNLRVVGCPYLDVLSEKIKNLPEKSSDFTVLIAPSWGASGILSKYGEQLITPLVETGWNIIIRPHPQSKTSEPDMLKRLEGKYKDVANFVWDYNSENIDSLSKADIMISDFSSVIFDYCFLFDKPFLYCNNEFDHRPYDSGDLKETPWKFSVLKEIGVELNSNSFDHIKEIISEACKSETLKENRLKAKDTAWQNRGCAGKAVYDFLTEIKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MT2</accession>
    <name>Q73MT2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyltransf_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972031.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679040.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1425"/>
    <dbReference type="EnsemblBacteria" id="AAS11942">
        <property type="protein sequence ID" value="AAS11942"/>
        <property type="gene ID" value="TDE_1425"/>
    </dbReference>
    <dbReference type="GeneID" id="2739702"/>
    <dbReference type="KEGG" id="tde:TDE_1425"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1366"/>
    <dbReference type="eggNOG" id="COG3146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073603_0_0_12"/>
    <dbReference type="OMA" id="MDYHADR"/>
    <dbReference type="OrthoDB" id="891566at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="187"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="335" mass="39261" checksum="045402286A44238C" modified="2004-07-05" version="1">MTKVFRIESYEKKYEQLWDDFVLNKSINGTFLQSRSFLNYHPEDRFEDCSLLIFNQKDNLAAVIPACKDPKDPTCFFSHKGSTYGGIIIDKKHYSGNGLLEIIEVFEQYLMENRYTSVYLKITPDILSIESPALLEYLLYYKKYQQYSELNTYIDLENYDEHIVSNFSQGKRTNITNCLKIGAVCRQIHTSDEIQALYTILAHTLRKYNTKPVHSFNEFMELKNVHISDNISFFGEYIQNDLVAGAVLFYFPKTKTIHTQYLCSKEEFAKLSPMSFMYYSMIVEAKKINYKRISWGVSTEDFGHYLNQGLLKNKESYGSTYSINKIFYKMLTPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MT8</accession>
    <name>Q73MT8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972025.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679026.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73MT8"/>
    <dbReference type="STRING" id="243275.TDE_1419"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="DNASU" id="2739696"/>
    <dbReference type="EnsemblBacteria" id="AAS11936">
        <property type="protein sequence ID" value="AAS11936"/>
        <property type="gene ID" value="TDE_1419"/>
    </dbReference>
    <dbReference type="GeneID" id="2739696"/>
    <dbReference type="KEGG" id="tde:TDE_1419"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1361"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_4_0_12"/>
    <dbReference type="OMA" id="CWWSLLG"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="345" mass="40830" checksum="B4606D30880EBDDF" modified="2004-07-05" version="1">MEPELTIIMSNYNQSKYIKSAIDSVLSQKTNFNWQLLITDDNSTKDNSIEIIKEYVHRYPDKIKALFNKKNGGYLENVLRAKKITKTPYFCLLDADDYWLDDLFLQRSYDFLQKHLEYVIYYENVKCLLPDGTCYPFINSNIVNSSYTIEDLFAGRIYITQTTGQFYRNVLFKNGIPEIIETAIGTVSEHSFEGDTDRFILHLKYGKAYFNNIMCGVYRILPNAGIWSRLTQFKKNLLAAQSYYDYFRYFEYTHADYFIHHSLFYVKECFEELKKAIDKNEFTQTIIQSDIIQLFDIIVEDEKYFKEAAADNGKIYKKKSIAIKKIIKFLLPYGFVRLIQKIRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MU1</accession>
    <name>Q73MU1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972022.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679019.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1416"/>
    <dbReference type="EnsemblBacteria" id="AAS11933">
        <property type="protein sequence ID" value="AAS11933"/>
        <property type="gene ID" value="TDE_1416"/>
    </dbReference>
    <dbReference type="GeneID" id="2739693"/>
    <dbReference type="KEGG" id="tde:TDE_1416"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1358"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060703_3_0_12"/>
    <dbReference type="OMA" id="GFAWFQK"/>
    <dbReference type="OrthoDB" id="1543624at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="33"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="283" mass="32628" checksum="82E7060BF830227E" modified="2004-07-05" version="1">MPTCEESWDLIIEPKRKLLDIPIREVIRYRDLIALFIKRDFVTQYKQTILGPLWFIINPLISTVMYAFVFGNLAKLSTDGVPHILFYYAGTMLWTFFAGCFTDATNIFVNNKDLFGKVYFPRLTVPISNIASNVTRILVQFLCLMGFFVYYFVTSDVLRPSFFTFFFPFLLIWIAAVATGMGMVISALTTKYKDLRLLVNFALNLAMYATAVVYPVSQIPQRFHWVLYANPMNAPIELFRVWFYGAGGIPSQAIISSILLTFLFLFLGLIMFNQNERNFIDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MU4</accession>
    <name>Q73MU4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoenolpyruvate mutase</fullName>
            <ecNumber evidence="2">5.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.2.9" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972019.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679012.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73MU4"/>
    <dbReference type="STRING" id="243275.TDE_1413"/>
    <dbReference type="EnsemblBacteria" id="AAS11930">
        <property type="protein sequence ID" value="AAS11930"/>
        <property type="gene ID" value="TDE_1413"/>
    </dbReference>
    <dbReference type="GeneID" id="2739690"/>
    <dbReference type="KEGG" id="tde:TDE_1413"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1355"/>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_0_1_12"/>
    <dbReference type="OMA" id="IIHGDDW"/>
    <dbReference type="OrthoDB" id="405831at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050188">
        <property type="term" value="F:phosphoenolpyruvate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012698">
        <property type="entry name" value="PEnolPyrv_PMutase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02320">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="3">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="433" mass="48427" checksum="6A9EBC2D13467C48" modified="2004-07-05" version="1">MEKRVYLGLTADIIHPGIINIINEGAKHGQLIIGLLTDSAIVSHKRLPYLTYEQRKQVVENIKGVSKVVPQEDWSYIPNLKKLKPDFIIHGDDWKSGSLSKIRDEVIEVMKEWGGEVIEVPYTKGINSSALASNMHSIGTTPEIRMKTLRRLIEAKPIVRIMEAHSGLSGLIIENLEVQKDDGVHRYDGMWSSSLTDSTSKGKPDIEAVDLTTRLQGLTDILECTTKPIIFDGDTGGKTEHFVFTVRTLERNGVSAIIIEDKVGLKKNSLFGTEAKQELADVEDFCHKISEGKKAQVTKDFMIIARLESLIAGHSVDEALERAFAYVKAGADGVMIHSKEKHGNDIKEFCERFRKEYEKVPIVLVPTTYNQFTEKELASWGANIIIYANHMLRASYPAMLKAAQTILEAERSLEVNDMCLSIKQILELIPGTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MV2</accession>
    <name>PURQ_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit PurQ</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase subunit I</fullName>
            <shortName evidence="1">FGAR amidotransferase I</shortName>
            <shortName evidence="1">FGAR-AT I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutaminase PurQ</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purQ</name>
        <name type="ordered locus">TDE_1405</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972011.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MV2"/>
    <dbReference type="SMR" id="Q73MV2"/>
    <dbReference type="STRING" id="243275.TDE_1405"/>
    <dbReference type="EnsemblBacteria" id="AAS11922">
        <property type="protein sequence ID" value="AAS11922"/>
        <property type="gene ID" value="TDE_1405"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1405"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1347"/>
    <dbReference type="eggNOG" id="COG0047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_3_0_12"/>
    <dbReference type="OMA" id="LHFVCRD"/>
    <dbReference type="OrthoDB" id="1527083at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00421">
        <property type="entry name" value="PurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000100602" description="Phosphoribosylformylglycinamidine synthase subunit PurQ">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00421"/>
        </source>
    </evidence>
    <sequence length="270" mass="29748" checksum="9CC6964A7938A52C" modified="2004-07-05" version="1">MKPRALVLHATGTNRDGDAARALELAGAEPEIVHINKLKAKEKNWKDYEILVIPGGFSYADALGAGKLFALDLSNYFFDEVSEFVAAGKPVIGICNGFQVLVKSGILPGKEKDGKVILDKDGYKNRQATLTYNKQGRFECRFTTMIPQKSNCIWTKDLKGNIHCPIAHGEGRFLTDSQKTLDDLFEKGQIALVYGGKDAEKSIPANGEYPFNPNGSLADIAGICNTKGNVLGLMPHPENNVVIRERDSEEEKERTKLCLDMWKAGVNYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MZ6</accession>
    <name>Q73MZ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xanthine/uracil permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971966.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671452.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1360"/>
    <dbReference type="EnsemblBacteria" id="AAS11877">
        <property type="protein sequence ID" value="AAS11877"/>
        <property type="gene ID" value="TDE_1360"/>
    </dbReference>
    <dbReference type="GeneID" id="2739461"/>
    <dbReference type="KEGG" id="tde:TDE_1360"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1307"/>
    <dbReference type="eggNOG" id="COG2252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024508_0_1_12"/>
    <dbReference type="OMA" id="RKGSYFF"/>
    <dbReference type="OrthoDB" id="558559at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="434" mass="45934" checksum="7AFECE535F7C4CE8" modified="2004-07-05" version="1">MERFFRLKEHNTTVRTEVIAGITTFLAMAYILAVNPGILSEAGMDRGAVFTATALSAAIATLAMGLLANLPVALASGMGLNAFFTYSVVIGLGYSPSTALTAVFLEGVLFILLSLVNVREAIVKSIPLNLKKAVAAGIGIFITFIAFQNSGIIVDNPATLVGLGKFTWGSPAVLAMIGLIITCALFILRVPGAILIGILITTIIGIPLKITVPFGGWEGWSPISLPSAPAVLNFDFSNILSFKFFIVFFSFLFVDIFDTVGTLVGVATQANLVDKDGNIPKIKQAFLSDAIGTVVGAALGTSTVTSYVESTAGVAAGGRTGLTSVVTAGMFIIALLFSPIFLLIPSAATAPALIIVGFLMMTQAGEINYKDPTEGIPAFLTMIMMPFTYSVAEGIVYGVLAYVILKCIKGKFKEIPVVTWILFVIFMLRFFVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N04</accession>
    <name>Q73N04_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penicillin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971958.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671463.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1352"/>
    <dbReference type="EnsemblBacteria" id="AAS11869">
        <property type="protein sequence ID" value="AAS11869"/>
        <property type="gene ID" value="TDE_1352"/>
    </dbReference>
    <dbReference type="GeneID" id="2739453"/>
    <dbReference type="KEGG" id="tde:TDE_1352"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1300"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_1_2_12"/>
    <dbReference type="OMA" id="TLACKTG"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="4">
        <location>
            <begin position="55"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="3">
        <location>
            <begin position="261"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="617" mass="69747" checksum="4A51B2CCB784C920" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N32</accession>
    <name>Q73N32_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FecR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971930.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678868.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73N32"/>
    <dbReference type="STRING" id="243275.TDE_1324"/>
    <dbReference type="EnsemblBacteria" id="AAS11841">
        <property type="protein sequence ID" value="AAS11841"/>
        <property type="gene ID" value="TDE_1324"/>
    </dbReference>
    <dbReference type="GeneID" id="2741058"/>
    <dbReference type="KEGG" id="tde:TDE_1324"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1273"/>
    <dbReference type="eggNOG" id="COG4254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092443_1_0_12"/>
    <dbReference type="OMA" id="ANIRLEW"/>
    <dbReference type="OrthoDB" id="2009486at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285849" description="FecR domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="2">
        <location>
            <begin position="55"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="231" mass="24151" checksum="29A0AD03AD7ED979" modified="2004-07-05" version="1">MKKVFLIISLVCFMLTPLLAISGEVVAVKGKAEIKQGGKWIPARAGNKITSGLMISTGFKSELTLKIDGSVITVKPMTRLTIEEIAEKNETVSSEVYLNVGSVKADVKPASTKKVEFKVKTPVATASVRGTSGEIGSDGLLIGTSGIWSYVNNDGIETRVNIGDSVIISDTGMVTPAQNIKANEVLPASVATLAEAEANSPTLTNQSPGIEDAINTAASVSTLSLSIGWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NE6</accession>
    <name>Q73NE6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA processing protein DprA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971814.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677699.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1207"/>
    <dbReference type="EnsemblBacteria" id="AAS11725">
        <property type="protein sequence ID" value="AAS11725"/>
        <property type="gene ID" value="TDE_1207"/>
    </dbReference>
    <dbReference type="GeneID" id="2740101"/>
    <dbReference type="KEGG" id="tde:TDE_1207"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1162"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029601_3_1_12"/>
    <dbReference type="OMA" id="YSKQHTI"/>
    <dbReference type="OrthoDB" id="1881437at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="310" mass="34521" checksum="ED37B82010BDB494" modified="2004-07-05" version="1">MKISEKESLYIGLSHCYFLKGREKLVLSEKLDSLSSLVSLSLKDISEIIGRQVRPKKWDKDLLKSLTDSSIKLMSSYGIRMLYFYDSDFPPQLREIPDHPFTVFYRGLLPSPEQPMLAMVGTRRPTGDGIEQALNLGKECAEKNIPVVSGLAFGIDCFSHKGCLEGEGKTLAVLACGPEMIYPRSNKKLAANILESSGCILSEYAPGTEPLSYRFPERNRIISGLSRSVLIVEAPKKSGALITADFALEQGRDVYVCGLLLNSLQNEGGKALYEQGAFAIKSIDDILHDWKYPTENNLRNNQQNMLFTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NF4</accession>
    <name>Q73NF4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cell division protein FtsL, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971806.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668438.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1199"/>
    <dbReference type="EnsemblBacteria" id="AAS11717">
        <property type="protein sequence ID" value="AAS11717"/>
        <property type="gene ID" value="TDE_1199"/>
    </dbReference>
    <dbReference type="GeneID" id="2741160"/>
    <dbReference type="KEGG" id="tde:TDE_1199"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1154"/>
    <dbReference type="eggNOG" id="ENOG5032IEC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163435_0_0_12"/>
    <dbReference type="OMA" id="IWVITIP"/>
    <dbReference type="OrthoDB" id="1911801at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011922">
        <property type="entry name" value="Cell_div_FtsL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04999">
        <property type="entry name" value="FtsL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="94" mass="10784" checksum="F2D780C43BE0F613" modified="2004-07-05" version="1">MKKILAVLFTLFIPLFLFAVVLQSSRYTSVERDLADYNKEQSKIIDENKKKISGISILSKPERIERIAVEELKMRKALSAEILRVSISKENKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NG7</accession>
    <name>Q73NG7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971793.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682434.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1185"/>
    <dbReference type="EnsemblBacteria" id="AAS11704">
        <property type="protein sequence ID" value="AAS11704"/>
        <property type="gene ID" value="TDE_1185"/>
    </dbReference>
    <dbReference type="GeneID" id="2740082"/>
    <dbReference type="KEGG" id="tde:TDE_1185"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1141"/>
    <dbReference type="eggNOG" id="COG0797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021208_0_0_12"/>
    <dbReference type="OMA" id="WQGTATV"/>
    <dbReference type="OrthoDB" id="1688916at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="458" mass="50098" checksum="BAC1691C42E0FA01" modified="2004-07-05" version="1">MNKKILFSLIFIISFSCIWAVWEGNGGIGSSTDFPAEGLFVRSDMFPKHTLLEITNLEKNVKARAVVIGPSGIPGLLASLSPELGEKLGVPRGKVIRIRVLTPSPVNEEGDDGKSISAAGPESQDLDNNPAIFVASHSDLPNANLKKEEAESVSENTGSDTILYDDLKSPIEDTPSETAEDVPVVEEVPDVNAIPDPVVEEPEVEPIKEVEKVEEKPAEDSSLMYAPETVAPITETYMEPAKENPPITVDPINEPAAKPEAAPAPVTEVSEPQKPEQPKEEIEDVEVVDPVVEPVDEAPVEEKKVDTVAAVTPKNEPIADKKEDPPAPAEETSVEETPVEEAEDSGTYDETDSDIYTTAEEKPEEESAVPVNEIKPVSSKLEKGKTYVQIVIYDDKYNRDDVLKKYGKKYPMVVEERLVKNNTRYTIFVGPLKPDETGAVLERFKQLGFKDAFLKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NH9</accession>
    <name>Q73NH9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Site-specific recombinase, phage integrase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971781.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956919.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1173"/>
    <dbReference type="EnsemblBacteria" id="AAS11662">
        <property type="protein sequence ID" value="AAS11662"/>
        <property type="gene ID" value="TDE_1173"/>
    </dbReference>
    <dbReference type="GeneID" id="2740070"/>
    <dbReference type="KEGG" id="tde:TDE_1173"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1131"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_17_5_12"/>
    <dbReference type="OMA" id="LYLDYYP"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025269">
        <property type="entry name" value="SAM-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13102">
        <property type="entry name" value="Phage_int_SAM_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="168"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="354" mass="40034" checksum="C7C59DEED1AE181C" modified="2004-07-05" version="1">MSVKLWINRNKIYLSIYISGKRWRESTGLTVTTDKAQNKVVMDMAEVLRSKREVSLIAVSNGLSDPALTKITVLEYVKNAAAEKNKKHPLHKVVLWIEKISPTLKMDALTPTWFENFQQTLQRETELSPYTCENYACSLRTLFKKAVRDGVLVKDPTIGVKHIHCPESIKEFLMPEDIRKLAAEPIGGILGADVKKAFLFACCTGLRISDLKSLKWGGVSFEKKTLTKIQQKTKRAVYLPIKDEAIAFLHLLAEENPNRTDEDFIFPHVATTGTNMNQYLIEWGKRAGVRQKIGWHLARHTHATLLLESGADLYTVQKLLGHTKISTTAQYTQVTDRKKKEAIDLLPDYGIVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NJ6</accession>
    <name>Q73NJ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971764.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1156"/>
    <dbReference type="EnsemblBacteria" id="AAS11645">
        <property type="protein sequence ID" value="AAS11645"/>
        <property type="gene ID" value="TDE_1156"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1156"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1115"/>
    <dbReference type="HOGENOM" id="CLU_160075_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="104" mass="12244" checksum="8C57187295A0B88A" modified="2004-07-05" version="1">MALAEITEQEKEIPEGLILTGFVKMKPDVKSEAACVLDNFLESLDWNFSYYDDIATEPTERMKKAALRFVKEVLKDYEVSVYEQVCIKKINVKRWLKKNSDWYK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NQ7</accession>
    <name>ALR_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alanine racemase</fullName>
            <ecNumber evidence="1">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">alr</name>
        <name type="ordered locus">TDE_1095</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971703.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682404.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NQ7"/>
    <dbReference type="SMR" id="Q73NQ7"/>
    <dbReference type="STRING" id="243275.TDE_1095"/>
    <dbReference type="EnsemblBacteria" id="AAS11584">
        <property type="protein sequence ID" value="AAS11584"/>
        <property type="gene ID" value="TDE_1095"/>
    </dbReference>
    <dbReference type="GeneID" id="2740225"/>
    <dbReference type="KEGG" id="tde:TDE_1095"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1054"/>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028393_2_2_12"/>
    <dbReference type="OMA" id="WEILCGF"/>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000066059" description="Alanine racemase">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="1">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <sequence length="379" mass="42227" checksum="6958BE9EEA85D48C" modified="2004-07-05" version="1">MRATKAIIHLDNLQYNIKEIKKRLNKNVKICLPVKADAYGHGAVRVAVAAIRAGVSYLAVASIQEAVELREAGIVAPIISLSLPVLEEIPELLKYDIEPLVIDEEFINDLNRFAKKLNKKAWVHLKIDTGMRRIGCSPMEAVKLAVQIDRAENLELKGVCTHFAVSDSTDEKNIKFTKKQISVFKDSIKEIKKAGINPGLIHAANSGSVLQYPEAQFDMVRPGILVYGYAPSPSLNSLIDLKPVMELVTQVVLIKKIEKDTSVSYDRCWTAEKETFVATLPIGYADGLMRSLSGLKVRIGKDFFPIIGRICMDQCMIDIGASPWVQRWDEVCIFGPVSKEHPKNNTAQDLAKIAGTIPYELTCDINKRVPRIFIDETIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NT1</accession>
    <name>Q73NT1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide ABC transporter, peptide-binding protein OppA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">oppA</name>
        <name evidence="3" type="ordered locus">TDE_1071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971679.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670584.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73NT1"/>
    <dbReference type="STRING" id="243275.TDE_1071"/>
    <dbReference type="EnsemblBacteria" id="AAS11560">
        <property type="protein sequence ID" value="AAS11560"/>
        <property type="gene ID" value="TDE_1071"/>
    </dbReference>
    <dbReference type="GeneID" id="2740832"/>
    <dbReference type="KEGG" id="tde:TDE_1071"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1031"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_6_12"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004286014" evidence="1">
        <location>
            <begin position="22"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="82"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="591" mass="66717" checksum="9B953132FB05653F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NW4</accession>
    <name>Q73NW4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971646.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682348.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1038"/>
    <dbReference type="EnsemblBacteria" id="AAS11527">
        <property type="protein sequence ID" value="AAS11527"/>
        <property type="gene ID" value="TDE_1038"/>
    </dbReference>
    <dbReference type="GeneID" id="2741312"/>
    <dbReference type="KEGG" id="tde:TDE_1038"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.998"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039511_1_0_12"/>
    <dbReference type="OMA" id="HEFEASP"/>
    <dbReference type="OrthoDB" id="408854at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="523" mass="60362" checksum="8DB55BEE6125C033" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NX1</accession>
    <name>Q73NX1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971639.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1031"/>
    <dbReference type="EnsemblBacteria" id="AAS11520">
        <property type="protein sequence ID" value="AAS11520"/>
        <property type="gene ID" value="TDE_1031"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1031"/>
    <dbReference type="HOGENOM" id="CLU_3399004_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="31" mass="3843" checksum="A7ACB2B797A2E0DD" modified="2004-07-05" version="1">MQVLKNFSISRRYKINNPFFKILLFIQLRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NZ0</accession>
    <name>Q73NZ0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">UvrABC system protein A</fullName>
            <shortName evidence="14">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 17" type="primary">uvrA</name>
        <name evidence="17" type="ordered locus">TDE_1010</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971619.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956862.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1010"/>
    <dbReference type="EnsemblBacteria" id="AAS11500">
        <property type="protein sequence ID" value="AAS11500"/>
        <property type="gene ID" value="TDE_1010"/>
    </dbReference>
    <dbReference type="GeneID" id="2740990"/>
    <dbReference type="KEGG" id="tde:TDE_1010"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.970"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_12"/>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="330"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="607"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="14">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="14">
        <location>
            <begin position="750"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <begin position="651"/>
            <end position="658"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AAS11500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="954" mass="105608" checksum="18568829CDD711F0" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P18</accession>
    <name>Q73P18_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971591.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682295.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0981"/>
    <dbReference type="TCDB" id="1.B.56.1.2">
        <property type="family name" value="the spirochaete outer membrane porin (s-omp) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11472">
        <property type="protein sequence ID" value="AAS11472"/>
        <property type="gene ID" value="TDE_0981"/>
    </dbReference>
    <dbReference type="GeneID" id="2740553"/>
    <dbReference type="KEGG" id="tde:TDE_0981"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.943"/>
    <dbReference type="eggNOG" id="ENOG50335X9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076358_0_0_12"/>
    <dbReference type="OMA" id="QLWKYKA"/>
    <dbReference type="OrthoDB" id="1789708at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284624" evidence="1">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="319" mass="36244" checksum="EA224EDF0D7A4A9C" modified="2004-07-05" version="1">MKKLFIGIVLCSFLFLPLTAHEESHKSQSSEHYSNKKVAYTTTINAIVTWPPQALVGVTQNFKVPLMQFDNPLTKDNNINFKIGAELSPISFEGKFGIVWTPIAFLEFYTESRVGSGWNIKTLYGLALNKNNAGKSNYIPLNFSKSIYSFSFGGAFQFDLGAVIPNDWSHVVFRTDQAALYKAMSGVDSETSWLYQADSGENRNGWKYQASYLIGYKMPIFLDLIAMKIDVEKKLFASPKGLDNKVWGENLFLTTFGPIINFNIKKDYNIMLLAQWQTKPLYKGGGEADFYQTKILDTDKKTQVKFYQVGIVFYMNINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P96</accession>
    <name>Q73P96_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pcrA</name>
        <name evidence="9" type="ordered locus">TDE_0903</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971513.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682194.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0903"/>
    <dbReference type="EnsemblBacteria" id="AAS11394">
        <property type="protein sequence ID" value="AAS11394"/>
        <property type="gene ID" value="TDE_0903"/>
    </dbReference>
    <dbReference type="GeneID" id="2739943"/>
    <dbReference type="KEGG" id="tde:TDE_0903"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.874"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_2_12"/>
    <dbReference type="OMA" id="YQDTNRT"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="6"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="275"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="662" mass="75852" checksum="58D8B640CA49069B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PE2</accession>
    <name>Q73PE2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0857</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971467.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682130.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0857"/>
    <dbReference type="EnsemblBacteria" id="AAS11348">
        <property type="protein sequence ID" value="AAS11348"/>
        <property type="gene ID" value="TDE_0857"/>
    </dbReference>
    <dbReference type="GeneID" id="2741368"/>
    <dbReference type="KEGG" id="tde:TDE_0857"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.826"/>
    <dbReference type="eggNOG" id="ENOG503464J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_684929_0_0_12"/>
    <dbReference type="OrthoDB" id="773354at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="401" mass="46321" checksum="E201183E63A29456" modified="2004-07-05" version="1">MKNIKKILLVVFVGLLFGCRRETSLELEREEKFTLNYGLFENELNLFNLNSTYSRPDTQILMKEGIFYIVNSGGQKILKLSSFGDLLTFFYNPESNMEPSFMQNDSQDVKATTRGAIKYPFNHPALLTVNSSKHLFVVDSVLDERIEYDHEENLALRDIILHFDENGTFIDYLGQEGFGGTPFPSIEGIHTNSSNDIIVVCRTQTSLKIYWYNRKGDLLYKIPIFFNAVPNPYESSNKIFSSIDKIIPDFNDLYLYIKIDYYLEEKDAATRANLGVSYDKSCLYFLNIKTGKYDKKMDIDAYEEIETSGTETFTFKKVYEMMGITESNWCYLLTPTTKGYALEMMNLKSQKKYKKDLIVSSDETFYNTFHVSSKGIISAILARDDKALIVWWRADKIIGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PF8</accession>
    <name>Q73PF8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971451.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670133.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0841"/>
    <dbReference type="EnsemblBacteria" id="AAS11332">
        <property type="protein sequence ID" value="AAS11332"/>
        <property type="gene ID" value="TDE_0841"/>
    </dbReference>
    <dbReference type="GeneID" id="2739618"/>
    <dbReference type="KEGG" id="tde:TDE_0841"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.810"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1255493_0_0_12"/>
    <dbReference type="OMA" id="HLISIEI"/>
    <dbReference type="OrthoDB" id="1387470at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="30"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="220" mass="25378" checksum="5BD5A81BE7FE8E8A" modified="2004-07-05" version="1">MKIKKVIFIFLLLAGVLFNLNAGERTMPVDMIIMIDKSLSMEDPGKFESLKRWVLDELIDQIIITGDWISIYQFYESPEHLISIEIKSKEDTNKIIKTVNKISPNGRFTDVGRALDKIQEAVNQRGENGRYKVLFMLTDLEQDAPITSKYSGKQKKFSSPYLVESRIIKHDNWYEITVDMGLDERVVKTSKALFSDIIKNNDKERVQSDENTALIKKDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PG6</accession>
    <name>Q73PG6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971443.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682092.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0833"/>
    <dbReference type="EnsemblBacteria" id="AAS11324">
        <property type="protein sequence ID" value="AAS11324"/>
        <property type="gene ID" value="TDE_0833"/>
    </dbReference>
    <dbReference type="GeneID" id="2739517"/>
    <dbReference type="KEGG" id="tde:TDE_0833"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.802"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_1_0_12"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="341" mass="37318" checksum="0AEC0D112B4C5C1C" modified="2004-07-05" version="1">MKKTLVIFLAVLLVSVLSCTNPFLKKMLVEDDTVKPDLGSFEDAGDFVKIIPPANGIAGVEPDPATLPGNEAKWKGVFIAGRKVKLSPYKLGKTEVTYKLWKEVYDWATGKGYQFAHPGTKGSSGTGNDKEQPVTKVSWRDCIVWCNAYTEMKMDENECVYRKSDSTVLKDSRDSAGAACDAAYADMKKRGFRLPTEAEWEYAARWQGSVETNAVQYGDVWLTKLYSASGATDKWDTAETGEVAWYSGNSGSKTNPVGKKRKNALGLHDMSGNVLELCFDWYASIVAGEVSDPQGATSGPGRVVRGGRWNCEAKFCTVGLRNYSTPYGKGDALGFRVACRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PH9</accession>
    <name>Q73PH9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971430.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0820"/>
    <dbReference type="EnsemblBacteria" id="AAS11311">
        <property type="protein sequence ID" value="AAS11311"/>
        <property type="gene ID" value="TDE_0820"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0820"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.792"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_6_0_12"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="219" mass="25528" checksum="AC3C6EAD12C07B04" modified="2004-07-05" version="1">MDNNTEKIFADKDELNTRTKILHAAKQEFLNKEFADTNVRAIAEKAGVTTGALYNLFDNKDGIFEALVSGVFDEFLDIVAHRDVFDAENFGMKTSDLSAIIELSQRRFLKMVDFFYDNWDAMKLIVCCSKGSSYEHIFDKAIDLIDRKTLQWLKQDGVKLSRRIRFFIHVMVTISFENLKEIFYHNLKKTEAVDYVLDFNVYHCAGWKQYWMEQVKGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PK3</accession>
    <name>Q73PK3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_0796</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971406.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682046.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0796"/>
    <dbReference type="EnsemblBacteria" id="AAS11287">
        <property type="protein sequence ID" value="AAS11287"/>
        <property type="gene ID" value="TDE_0796"/>
    </dbReference>
    <dbReference type="GeneID" id="2740674"/>
    <dbReference type="KEGG" id="tde:TDE_0796"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.769"/>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054611_1_0_12"/>
    <dbReference type="OMA" id="ICNSDAH"/>
    <dbReference type="OrthoDB" id="1615112at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="8">
        <location>
            <begin position="10"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="269" mass="30597" checksum="6D5B4BB60BD9B90A" modified="2004-07-05" version="1">MKTNNLISNFHTHTYLCKHAEGKPIDYVKEAIKAGCSALGFSDHCPYPDSSWDYCRMGEYEVNLYKSMVEEAAIDAPFPVYFGFECEWHPRYKSWYKDFLREELKSDFLVLGSHWYDVDGRLEYAPTLTKKELFGYIDFTIEGMSSGLYNFLAHPDLFLADVSNIDSDHLACSRALIQAAIDLDVPIEINGYGTFKRKIVRAGRDEFIYPVRQFWELASDMGARIICNSDAHFPKHTILGCRNAMAFAASLGIKVQDTAEALGFRSING</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PP1</accession>
    <name>Q73PP1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron compound ABC transporter, ATP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0756</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971367.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682019.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0756"/>
    <dbReference type="EnsemblBacteria" id="AAS11248">
        <property type="protein sequence ID" value="AAS11248"/>
        <property type="gene ID" value="TDE_0756"/>
    </dbReference>
    <dbReference type="GeneID" id="2739875"/>
    <dbReference type="KEGG" id="tde:TDE_0756"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.731"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_12"/>
    <dbReference type="OMA" id="QVHKYYG"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="253" mass="28401" checksum="9724F075CD12371C" modified="2004-07-05" version="1">MVLDISSLSFNFGSKNILADIDLSIKDNGIVGIIGPNGSGKSTLLKCIYRVLKPKTGTIFIDGKNINDYQFKETAKKMAVVAQHNDTHFDFNVLEMVLIGRSPHKKFMERDSAEDIELAYKALEQVNMKDFADRNFSSLSGGEKQRIILARALVQNTDCLILDEPTNHLDIKHQLHFMSLAKDLKITVISAIHDLNIAAMYCDKIYALKEGQIIAAGSVNEVITEEVIKTLYDVEAKIIYDEEKKPHVIFKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PP7</accession>
    <name>Q73PP7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Magnesium chelatase, subunit D/I family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971361.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682011.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0750"/>
    <dbReference type="EnsemblBacteria" id="AAS11242">
        <property type="protein sequence ID" value="AAS11242"/>
        <property type="gene ID" value="TDE_0750"/>
    </dbReference>
    <dbReference type="GeneID" id="2739869"/>
    <dbReference type="KEGG" id="tde:TDE_0750"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.725"/>
    <dbReference type="eggNOG" id="COG1239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016684_6_0_12"/>
    <dbReference type="OMA" id="YYHLPKA"/>
    <dbReference type="OrthoDB" id="1068772at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01451">
        <property type="entry name" value="vWA_Magnesium_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041702">
        <property type="entry name" value="BchD/ChlD_VWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="447"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="643" mass="72718" checksum="96E75AF0F5D129A8" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PQ3</accession>
    <name>Q73PQ3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxA</name>
        <name evidence="6" type="ordered locus">TDE_0744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971355.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682000.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0744"/>
    <dbReference type="EnsemblBacteria" id="AAS11236">
        <property type="protein sequence ID" value="AAS11236"/>
        <property type="gene ID" value="TDE_0744"/>
    </dbReference>
    <dbReference type="GeneID" id="2740298"/>
    <dbReference type="KEGG" id="tde:TDE_0744"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.719"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_12"/>
    <dbReference type="OMA" id="QVGVAPK"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="4">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="105" mass="11925" checksum="0322F98B7CD30B2B" modified="2004-07-05" version="1">MIELTKENFEQEVHQSKGVTFVDFWSDGCVPCKQLMPDVHAMAERHAGKAKFCSFNIDGARRVAMKEQVLGLPTMLIYIDGERKDSVTGSDLTINQIEEMVKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PS4</accession>
    <name>Q73PS4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971334.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681959.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0722"/>
    <dbReference type="EnsemblBacteria" id="AAS11215">
        <property type="protein sequence ID" value="AAS11215"/>
        <property type="gene ID" value="TDE_0722"/>
    </dbReference>
    <dbReference type="GeneID" id="2740086"/>
    <dbReference type="KEGG" id="tde:TDE_0722"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.698"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040161_0_0_12"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSPc" evidence="1">
        <location>
            <begin position="182"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="421" mass="48856" checksum="90AEAF6225DE8223" modified="2004-07-05" version="1">MKKQFLFILIFIFIIFFACSDYTNGDEVRFISYKKMLSDYEYFWDFIYKGYPFSEVCERNGADLKKMKIKNYESLSGLASENAYLAFYDRLCRQITIGKSIGHLYAVDKYDYKYVFKTSMIGGPFITKILLIDGFYSKLIGGRSSTEIEKNIFYCDFFNDEFPCYSCDIYTGFLKRIIEPGKIAYVKLDSFLIVSREIELQYLRDLKDFFIETADYKHIIIDIQNNGGGYIENYEAIISPNIKENLTIVSYGLYNENKYTNPYLEMFFKGYRDIKKIEKHEVPNIENCGTVKNDKAYKLEDMIEPSYILDYKPCEDKKFWLLVSGDVYSAADRFTYVCKKTGFATVIGTNTKGAGNNGLWPMYIVLPNSGLLIKFDFIYGLTDDGYCTDEFGTAPDIYNLPGKDALETCLEEIRKLGEKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PW0</accession>
    <name>Q73PW0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="7">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">purC</name>
        <name evidence="9" type="ordered locus">TDE_0686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971298.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681898.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0686"/>
    <dbReference type="EnsemblBacteria" id="AAS11179">
        <property type="protein sequence ID" value="AAS11179"/>
        <property type="gene ID" value="TDE_0686"/>
    </dbReference>
    <dbReference type="GeneID" id="2740245"/>
    <dbReference type="KEGG" id="tde:TDE_0686"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.666"/>
    <dbReference type="eggNOG" id="COG0152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045637_0_1_12"/>
    <dbReference type="OMA" id="TKFEFGF"/>
    <dbReference type="OrthoDB" id="1345271at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="8">
        <location>
            <begin position="19"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="316" mass="36165" checksum="500FFD77B17271DE" modified="2004-07-05" version="1">MISRNAAFRESNLPLPSKQTGKVRDWYSPEEGKRLIVTTDRISAFDRVLTALPYKGQVLNQLSLWWFENTKDIIKNHIISCPDPNCIIVTEVKPLPIEVIVRGYITGVTSTALWYRYSLGERNIYGYDFPEGLKKNQALPKPIITPTTKGGPTGHDERLTCDEVVSQGYLSKEQWDFVQKAALALFERGQKSAKEAGLILVDTKYEFGVDKNNNILLIDEVHTPDSSRYWKLDTYEQRLKEGKEPENFDKEFVRMAYAAKGYRGDGEIPELDENVWNEAIQLYITAYEKLTKSKFVPGEYPAEERIVKNLKKAGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PY1</accession>
    <name>Q73PY1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971277.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681866.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0664"/>
    <dbReference type="EnsemblBacteria" id="AAS11158">
        <property type="protein sequence ID" value="AAS11158"/>
        <property type="gene ID" value="TDE_0664"/>
    </dbReference>
    <dbReference type="GeneID" id="2739212"/>
    <dbReference type="KEGG" id="tde:TDE_0664"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.644"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045523_1_0_12"/>
    <dbReference type="OMA" id="RGIPRFP"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="2">
        <location>
            <begin position="305"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="422" mass="48785" checksum="10D24E1CF83E840E" modified="2004-07-05" version="1">MKYRIFKNNILKKLVLFVFVLLFSLLFAQEGEKNAEFLFKFKFIDDDAYKIHSVVDEKVYVNGKFHHKAQIINRIEVEVSDIETGEGEKNASALFSCMFMTSEQNSNKTFDWSRNYPSIFRRDDAGFYTIGDEYFMPVVRNVPTFPKHPVKPGDTWTGEGFEAHDFRDAFGIEKPFTFPFKVEYQYIGLAEIDGQIYRHITASYDLNHVVPQKVLKNYKGKIDVPVKILGKSRQNLYWDEERGNLYCYNEEFSIKMLLYSGYTYDFIGTARAKVIEVKKIDKAAEEEIKKSVEDLNLENTTIEKTDEGLTISIENIQFLPNSAILRESEKEKLKKIGEILLKFPDREFLISGHTALAGTEEERQALSEERAAAVANYLIELGVQKREHVYTRGFGARRPVAANNSPENMAKNRRVEITILDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q10</accession>
    <name>Q73Q10_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_0634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971248.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677008.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0634"/>
    <dbReference type="EnsemblBacteria" id="AAS11129">
        <property type="protein sequence ID" value="AAS11129"/>
        <property type="gene ID" value="TDE_0634"/>
    </dbReference>
    <dbReference type="GeneID" id="2739359"/>
    <dbReference type="KEGG" id="tde:TDE_0634"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.612"/>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_6_12"/>
    <dbReference type="OMA" id="IEMHLIV"/>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="222"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="314" mass="34226" checksum="FADC9628EC6610A6" modified="2004-07-05" version="1">MNNGNRIKLVRIASLISLIGNIIICIAKLVIGIYANSLSVIGDGIDSATDVAISIMTLAVSFIIGRPSDKEHPWGHQRAETMASLILAFIIMIAGFQLCITAGGKLINVYKGTVTILMPHILAVIVTVSSIAVKLLLALNQYIIGKKTGSMMIQANAKNMTNDVILSASVLAGLAISRFFKAPIFDAVTALLVSLWIMKSGIDLFMELNVELMDGNTNDILYKQLFEAVNSVEGAHNPHRARIRRMANLLDIDLDIEVDAEMSICEGHSIAEKVTSAIKEKIENVYDVMVHIEPYGIHNHEEEGFGLSEKDINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q28</accession>
    <name>Q73Q28_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971230.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0616"/>
    <dbReference type="EnsemblBacteria" id="AAS11111">
        <property type="protein sequence ID" value="AAS11111"/>
        <property type="gene ID" value="TDE_0616"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0616"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.595"/>
    <dbReference type="HOGENOM" id="CLU_3141867_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="49" mass="5701" checksum="BED95BB3E81E80C0" modified="2004-07-05" version="1">MLKRGNGKTYQLYKKMQKSFSKVLDIKLVYLKKFAASQLRSFAASQLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q30</accession>
    <name>Q73Q30_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Precorrin-4 C11-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.133</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cobM</name>
        <name evidence="7" type="ordered locus">TDE_0614</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.133" evidence="7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971228.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681800.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0614"/>
    <dbReference type="EnsemblBacteria" id="AAS11109">
        <property type="protein sequence ID" value="AAS11109"/>
        <property type="gene ID" value="TDE_0614"/>
    </dbReference>
    <dbReference type="GeneID" id="2740459"/>
    <dbReference type="KEGG" id="tde:TDE_0614"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.593"/>
    <dbReference type="eggNOG" id="COG2875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_7_1_12"/>
    <dbReference type="OMA" id="WSAMGEQ"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="249" mass="27322" checksum="854ED8AAFB00D252" modified="2004-07-05" version="1">MVYFVGAGPGDPDLITIKGRKLIEKADIVIYAGSLVSAEHITFAKPNCKTYNSASMTLEEVIKVMEENCNAQIVRLHTGDPSIYGAVREQMDELDKLRIDYEVIPGVSSCTAAAAAIKKEFTLPDVSQTIILTRMEGRTPVPQEEKLAALAAHKASMAIFLSVQNIENVVAELLKGYKDEATPAAVIYKATWEDQEIITGTLGDIAQKVKKAGINKTAQILVGNFIAGDYKRSQLYNPKFSHEFRKAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QA5</accession>
    <name>Q73QA5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971152.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681688.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0538"/>
    <dbReference type="EnsemblBacteria" id="AAS11033">
        <property type="protein sequence ID" value="AAS11033"/>
        <property type="gene ID" value="TDE_0538"/>
    </dbReference>
    <dbReference type="GeneID" id="2741757"/>
    <dbReference type="KEGG" id="tde:TDE_0538"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.524"/>
    <dbReference type="eggNOG" id="ENOG5033WIB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073604_0_0_12"/>
    <dbReference type="OMA" id="ANRICMS"/>
    <dbReference type="OrthoDB" id="1005401at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="327" mass="37948" checksum="3FE076849AF6F823" modified="2004-07-05" version="1">MNGKNIGRTVSWVYYKDEKLIGGPAFDIQLFRQILENNAKFSSQAQEMIETQIKEQNIFDCISLKSSKYTNRFYENSGHKAFIPESICMVDYCEGEIFAVVRIGDRCEIVSYDYDITGEAGQEWFNFIGKNKPIFDKKIIENIKTVLTQYEQLQIKILEEEDRRIWEEKEKLACRNKSLPADTEQTFLSLCKLLGISPQKAKKIYHTALEQENICVSLINDFIDLNYLAMFDWKADVGDIVYGYNLVAKKIKANMLHLDKDTEFEPPEVFRRLASMSDKVLYLIDTNSDCYILGLSDKENREKIISAYKQLFSLLQSENTIEIVNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QC5</accession>
    <name>Q73QC5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971132.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676878.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0518"/>
    <dbReference type="EnsemblBacteria" id="AAS11013">
        <property type="protein sequence ID" value="AAS11013"/>
        <property type="gene ID" value="TDE_0518"/>
    </dbReference>
    <dbReference type="GeneID" id="2739255"/>
    <dbReference type="KEGG" id="tde:TDE_0518"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.504"/>
    <dbReference type="eggNOG" id="ENOG5033F6N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1593819_0_0_12"/>
    <dbReference type="OrthoDB" id="1987359at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="186" mass="22231" checksum="6ED9D4E2590B9F39" modified="2004-07-05" version="1">MNFWIAIPVDDFFRYSNDIMKKYGVSAYVEVIDNKSGNRNVYTYREDRPNVFTEYFFEESYHSFYFSCYPFDDEKSSIPFGAFYTPEIAPFTIEGNGGYETESTREQIYLRQIDKRPDKNIKKFYSALQQKLKTLPGIQNGCVMGKYEYKNRYFLPSSKIIIPNNPHNKNIKGTWEDYYLNYQYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QF9</accession>
    <name>Q73QF9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_0484</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971098.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681580.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0484"/>
    <dbReference type="EnsemblBacteria" id="AAS10979">
        <property type="protein sequence ID" value="AAS10979"/>
        <property type="gene ID" value="TDE_0484"/>
    </dbReference>
    <dbReference type="GeneID" id="2741389"/>
    <dbReference type="KEGG" id="tde:TDE_0484"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.469"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_12"/>
    <dbReference type="OMA" id="AKNANTI"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="319"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="420"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS10979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="706" mass="76587" checksum="E097EDE4DF20852A" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QH1</accession>
    <name>Q73QH1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971086.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002665998.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0472"/>
    <dbReference type="EnsemblBacteria" id="AAS10967">
        <property type="protein sequence ID" value="AAS10967"/>
        <property type="gene ID" value="TDE_0472"/>
    </dbReference>
    <dbReference type="GeneID" id="2740519"/>
    <dbReference type="KEGG" id="tde:TDE_0472"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.457"/>
    <dbReference type="eggNOG" id="ENOG5033GV8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151795_3_1_12"/>
    <dbReference type="OrthoDB" id="2095414at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046092">
        <property type="entry name" value="DUF6110"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19605">
        <property type="entry name" value="DUF6110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="72" mass="7428" checksum="C85536E7A3C259D1" modified="2004-07-05" version="1">MTRWGAFALGVVAGGAAVLLARNANFKKACAKVVGAGLKLKDDAAAFVETVKEDAQDIMAEAAYNKEAAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QI8</accession>
    <name>Q73QI8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase, GHMP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0455</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971069.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0455"/>
    <dbReference type="EnsemblBacteria" id="AAS10950">
        <property type="protein sequence ID" value="AAS10950"/>
        <property type="gene ID" value="TDE_0455"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0455"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.442"/>
    <dbReference type="eggNOG" id="COG0153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="4">
        <location>
            <begin position="13"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="401" mass="45305" checksum="143D205C675E4DF5" modified="2004-07-05" version="1">MDEAELKLELKKLFDEVYDASPEEGILIASPLSLTLMGEELDYNGGNVLNLCCDKSIYFFIRKNSSDKISLTDLVLNKKFEGLISGQAGKNQNPDSRKEGFASSIFNIILLTAQKINKHFENPLSGFDIMVFDKLRFKTGQTSLPAFEAGFCTGLLSIFKLKENFKVIASLCLEAEHEILNTKRGLSNQISSFSAKQDSLNLFDSRDLSFLSLPLNLREYGIVIIGTRSNSEAYRASSNIRYMECEEGLRILQNKLDLDHLCEITEADYTYYQPSFLDKTIMRRVKHCITENARTSKAVMALEKGDMDLLGKLLCESHISMRDDFELMSTEQNILFETAIIQRGCRGAKLVGNTEGCYILALVKKDALDEFYLEVHKRYFEKTGGSPEFFEFKSAAGVRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QL9</accession>
    <name>Q73QL9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacteriocin-type signal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971038.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956741.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0424"/>
    <dbReference type="EnsemblBacteria" id="AAS10919">
        <property type="protein sequence ID" value="AAS10919"/>
        <property type="gene ID" value="TDE_0424"/>
    </dbReference>
    <dbReference type="GeneID" id="2739588"/>
    <dbReference type="KEGG" id="tde:TDE_0424"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.411"/>
    <dbReference type="HOGENOM" id="CLU_448282_0_0_12"/>
    <dbReference type="OrthoDB" id="2156795at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="607" mass="67706" checksum="7BD49753844A41E7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QM4</accession>
    <name>Q73QM4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971033.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681458.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0419"/>
    <dbReference type="EnsemblBacteria" id="AAS10914">
        <property type="protein sequence ID" value="AAS10914"/>
        <property type="gene ID" value="TDE_0419"/>
    </dbReference>
    <dbReference type="GeneID" id="2739060"/>
    <dbReference type="KEGG" id="tde:TDE_0419"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.406"/>
    <dbReference type="HOGENOM" id="CLU_049884_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010103">
        <property type="entry name" value="Clustered_lipoprot_TREDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09710">
        <property type="entry name" value="Trep_dent_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01781">
        <property type="entry name" value="Trep_dent_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284648" evidence="1">
        <location>
            <begin position="24"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="427" mass="51083" checksum="F4B7DAE66ADDF7D5" modified="2004-07-05" version="1">MKKDKLKFIFILILAFLLFSCKASDTKSGREMRIEKFSKMIESNKISGVSGKGKEDEFVGTPFVLDDYDLVYIQALYTRTNIGKDNRIYYTDVEVIKFEREKEIECRQKRTAKNGKDFFYSIKYEWDKRAKKFVNTKYELEQELNIGVIDEKIIKEQVHGIVIESKEDPDRESLIPMFESYMTKLDKNDKYHYTYYVLDYIRGNFTNSGYDEYIVFFTNDSRKEMEEAGEHHPNFYSKDGKLSDITWKNNICDIACFIVEGSTFKKVYNIYFRGSIFLPAYEKSSSLYGSLNPRQMPYITNFGKQFFQGWVADLNQNGINEIYIYFPWKGTVRITMAEFIDKDFEFKCIEILGDEFNNVDWHKKTFNGNYYSIELRDDTYGIIWYKEIFQWNEDDDNYWLQSCNISPNRSYKMSWDWTKDDWVNIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QN3</accession>
    <name>Q73QN3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase, M48 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_0410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971024.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676765.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0410"/>
    <dbReference type="EnsemblBacteria" id="AAS10905">
        <property type="protein sequence ID" value="AAS10905"/>
        <property type="gene ID" value="TDE_0410"/>
    </dbReference>
    <dbReference type="GeneID" id="2740156"/>
    <dbReference type="KEGG" id="tde:TDE_0410"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.397"/>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029002_5_2_12"/>
    <dbReference type="OMA" id="QIFITYA"/>
    <dbReference type="OrthoDB" id="1530824at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="87"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="288" mass="31506" checksum="481882C3D6953816" modified="2004-07-05" version="1">MKKKFGLFVIISLIPVVVLSCALLGSLDDPLAFTKNAIDAAAPIVEASKPIENEEEYYIGREVAAIILSNYKLYRNKPLENYLNLICMTLVLNSDVPESYNGYHVAILDTDEINAFATPGGHVLVTKGLLSCADSEDALAGVIAHELGHIQLKHGIGAIKANRITAAAVESSATMAVGSEKKAELKFLEDASKEIVTTLVNSGYSKSQEYDADRFAVKLMARAGYDPNAMTEMLKIMSEKQKHDSRGFGKTHPSAVSRIKSVEKESKKLAGDYNRPARLNRYQKNKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QN9</accession>
    <name>Q73QN9_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0404"/>
    <dbReference type="EnsemblBacteria" id="AAS10899">
        <property type="protein sequence ID" value="AAS10899"/>
        <property type="gene ID" value="TDE_0404"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0404"/>
    <dbReference type="HOGENOM" id="CLU_3190264_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="46" mass="5617" checksum="E94A129BF5EA6CCD" modified="2004-07-05" version="1">MFAIIVTQPKSLVKQKYKKVTQNSHFFYNFSNFFAFFRHINNKNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QQ3</accession>
    <name>Q73QQ3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3343 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971004.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0390"/>
    <dbReference type="EnsemblBacteria" id="AAS10885">
        <property type="protein sequence ID" value="AAS10885"/>
        <property type="gene ID" value="TDE_0390"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0390"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.379"/>
    <dbReference type="eggNOG" id="ENOG50332WS">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167443_1_0_12"/>
    <dbReference type="OrthoDB" id="1844146at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021778">
        <property type="entry name" value="Se/S_carrier-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11823">
        <property type="entry name" value="DUF3343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3343" evidence="1">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="85" mass="9899" checksum="E2CD266AACAF040E" modified="2004-07-05" version="1">MKNYYVFLPDSKTALKLYGLIKKEGIKCTMAPTPREAEACCGVSILYYDFSDTDKIKEIIEEEGIKISKFWESEKIFNPERNKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QS1</accession>
    <name>Q73QS1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_0372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970986.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681387.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0372"/>
    <dbReference type="EnsemblBacteria" id="AAS10867">
        <property type="protein sequence ID" value="AAS10867"/>
        <property type="gene ID" value="TDE_0372"/>
    </dbReference>
    <dbReference type="GeneID" id="2740124"/>
    <dbReference type="KEGG" id="tde:TDE_0372"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.362"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_529898_0_0_12"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
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            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="291"/>
        </location>
    </feature>
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            <begin position="320"/>
            <end position="514"/>
        </location>
    </feature>
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        <location>
            <begin position="351"/>
            <end position="358"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS10867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="514" mass="59270" checksum="084856B25FBA963E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QW1</accession>
    <name>Q73QW1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS10827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS10827">
        <property type="protein sequence ID" value="AAS10827"/>
        <property type="gene ID" value="TDE_0332"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.321"/>
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    <dbReference type="OrthoDB" id="2047542at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTHTETR"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="208" mass="24836" checksum="BE043DEFAD81EBEB" modified="2004-07-05" version="1">MAKFKRKTKEERTYEIIEAAKKVFLKKGFHNTTMEDIVAATSLSKGGVYQYFKSTKAIMFAIMQEGNYFRYRRNEEIFSSAKKIDDPYEIVTQALEAKLFDNVPEKRLYLMFLAEILYDKEYETLFWKLENQAHKFINENLEHLFKEGTFEGKKIKYKTNKTGRLYSRLFNGILIIYELFEDKTVFDEGKRELHDFLYSCVKKSFTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QX8</accession>
    <name>Q73QX8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein, HlyB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS10810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="RefSeq" id="WP_002681271.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0315"/>
    <dbReference type="EnsemblBacteria" id="AAS10810">
        <property type="protein sequence ID" value="AAS10810"/>
        <property type="gene ID" value="TDE_0315"/>
    </dbReference>
    <dbReference type="GeneID" id="2740514"/>
    <dbReference type="KEGG" id="tde:TDE_0315"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.304"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OMA" id="DRNVRGM"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Type_1_exporter"/>
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        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="42"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="341"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="375"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="594" mass="67814" checksum="E5BD8894B81FDA30" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R37</accession>
    <name>Q73R37_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970870.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681180.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0255"/>
    <dbReference type="EnsemblBacteria" id="AAS10751">
        <property type="protein sequence ID" value="AAS10751"/>
        <property type="gene ID" value="TDE_0255"/>
    </dbReference>
    <dbReference type="GeneID" id="2739680"/>
    <dbReference type="KEGG" id="tde:TDE_0255"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.250"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_12"/>
    <dbReference type="OMA" id="VCVQQAD"/>
    <dbReference type="OrthoDB" id="870493at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="269"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="301"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="474" mass="51728" checksum="370ABA1BFFCE3A2D" modified="2004-07-05" version="1">MIRMENVSFHYENSERGVSNINLTINEGECTVLTGPSGGGKTTILRLLNGLAPGYYSGALSGNISIGGKDMSSTPLWERGKFIGSVFQEPQSQFFSSELAGEIAFSCENYGLAQHEIIARTEGAIEAFHLATLRDHTLDTFSSGEKQRAAIASVYALSPSIYVCDEPTANLDEESAVRLSHVLKKLKEEGRTLIIAEHRLSWLYGIADRFIYIDGGTIQWSHTAEEMQKMTLEQKKLFGLRSFTPALKPDLPPPSSRALSSGTANEPLLQADGIYRKEKGNLILQTVSFPVSRGQIIALTGKNGVGKTTLGLILSGLNKESGGTVFLNGKKCGLWARRKAVWYSANDTGTQFFTESVSEEILLSMMNTPDKLERARNILQTMGLYDLKDVHPATLSGGQKQRLSVACALLSGRDILIFDEPTSGLDGYHADILAKAFLDAAARGKTIIVITHDFELIAACCSFEIMLEEEAQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R49</accession>
    <name>Q73R49_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970858.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681157.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0242"/>
    <dbReference type="EnsemblBacteria" id="AAS10739">
        <property type="protein sequence ID" value="AAS10739"/>
        <property type="gene ID" value="TDE_0242"/>
    </dbReference>
    <dbReference type="GeneID" id="2741441"/>
    <dbReference type="KEGG" id="tde:TDE_0242"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.237"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076847_3_0_12"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="236" mass="26980" checksum="9EA8851790399487" modified="2004-07-05" version="1">MNTKRKADPRTVLGIVFIFISFGLAVNKPLPSHVLLIICNFYLWDVRAYRESVLYSGMYSIIAVSMFYIHYIPNSTIALMIVSLSYFIQKFVIAVMMIIFLKKKTSMPSIISAMQTMKFPNIIAIPLIVVFRYLPSLKEDYGCLKDSLKIRGISISGLRFLMHPIRSLELIIVPILFRSLRIAEELSTSVLLRGIENYKNRTNIYPLKFTKTDFVYGLCTAIAVGAVSYLQFSNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RD2</accession>
    <name>Q73RD2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-dehydro-3-deoxy-phosphogluconate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:17089"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:57569"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.14" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970774.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681035.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0157"/>
    <dbReference type="EnsemblBacteria" id="AAS10655">
        <property type="protein sequence ID" value="AAS10655"/>
        <property type="gene ID" value="TDE_0157"/>
    </dbReference>
    <dbReference type="GeneID" id="2741745"/>
    <dbReference type="KEGG" id="tde:TDE_0157"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.155"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032130_0_0_12"/>
    <dbReference type="OrthoDB" id="1175355at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031337">
        <property type="entry name" value="KDPG/KHG_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00159">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="253"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="590" mass="63539" checksum="7DCE86F393601A5C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RD8</accession>
    <name>Q73RD8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein, YeeE/YedE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_0151</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970768.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681018.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0151"/>
    <dbReference type="EnsemblBacteria" id="AAS10649">
        <property type="protein sequence ID" value="AAS10649"/>
        <property type="gene ID" value="TDE_0151"/>
    </dbReference>
    <dbReference type="GeneID" id="2740839"/>
    <dbReference type="KEGG" id="tde:TDE_0151"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.149"/>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050656_1_1_12"/>
    <dbReference type="OMA" id="SLHGWLW"/>
    <dbReference type="OrthoDB" id="1899767at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="45"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="418" mass="45551" checksum="3E1C4A6C4F23A152" modified="2004-07-05" version="1">MKKIENIIGFAVLILSIVLGSVLLKTDMLFFRWVIGIALGYVLTRSLFGFAGSVNRAYRTGSTKLMRALMLMFVISAILTSAFLIFGDVKNYDLWINPINLGLILGGFLFGFGMSYSSCCATGTLTDLVTGLPRALITLLFFGIGVFVGLPIQAKQSWIKDSLFKSGTGSGVFIPDWFASNGKGGYLGAIIVTALFAGIIVVLSYMYESKRKKQNKYSGVGSEKDQDAVKELDTHNYKFFSEATYKKLFVEPWSLTMGAVLLSVLFTLLMGVTKAGWGASTPFGFWFGRLLKFFGMSVDSIVAFTGGKPKPYTMPFFEHPVFVQNIGIVAGTAICLLLAGSFTKSFKSELKIRVKDVIVFAIGGFAMGFGTRLSNGCNVGALYTPIANFSLSGWIFLIFLVAGGFLGNYTLKLINKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RE0</accession>
    <name>Q73RE0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970766.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666641.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0149"/>
    <dbReference type="EnsemblBacteria" id="AAS10647">
        <property type="protein sequence ID" value="AAS10647"/>
        <property type="gene ID" value="TDE_0149"/>
    </dbReference>
    <dbReference type="GeneID" id="2740837"/>
    <dbReference type="KEGG" id="tde:TDE_0149"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.147"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_12"/>
    <dbReference type="OMA" id="HQGNANF"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="137"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="201" mass="22425" checksum="0B335B65D7F2CD0B" modified="2004-07-05" version="1">MKIIIVDDDCLVVSSLKTILKANGFDIIATGSNGNEAITLFNEYKPDILLMDIRMQNMTGIEASEKILAEHSDAKILLLTTFNDEEYITKAINFGCKGYILKQNIDSLVPALNAVGAGSIVFDSEIISKIPQTKPARSQFKEDLNDRETDILELVADGLNNKEIANRLSLSEGTVRNYVSSILEKLNLRDRTQLVVYYYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RH7</accession>
    <name>Q73RH7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970728.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680969.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0111"/>
    <dbReference type="EnsemblBacteria" id="AAS10609">
        <property type="protein sequence ID" value="AAS10609"/>
        <property type="gene ID" value="TDE_0111"/>
    </dbReference>
    <dbReference type="GeneID" id="2741726"/>
    <dbReference type="KEGG" id="tde:TDE_0111"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.111"/>
    <dbReference type="eggNOG" id="COG1664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072799_6_5_12"/>
    <dbReference type="OMA" id="KNRVMLM"/>
    <dbReference type="OrthoDB" id="1968497at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="139" mass="14866" checksum="B261582D1E7E5FE5" modified="2004-07-05" version="1">MADFIDDISINTIIGPGTFVNGSLSVPGFLRVDGDINGDIKTPGRVIIAENARVRGNVHAKSITIGGMVQGDVIAPESVIVLSTGLILGSVLTKKIRLDDDVFLHGYCFAIDNQAEFEKAEKEYKNRQGLAASALVHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RN5</accession>
    <name>Q73RN5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase, TrmH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970667.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673320.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0050"/>
    <dbReference type="EnsemblBacteria" id="AAS10548">
        <property type="protein sequence ID" value="AAS10548"/>
        <property type="gene ID" value="TDE_0050"/>
    </dbReference>
    <dbReference type="GeneID" id="2741665"/>
    <dbReference type="KEGG" id="tde:TDE_0050"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.52"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1049463_0_0_12"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="120"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="262" mass="29728" checksum="418F8AAB6BF9359D" modified="2004-07-05" version="1">MPEIFKLYNLPQKQRCRKILRILESAETALVQNKADEFLDAFYLRSLLKIILDDLDSVSALKVQNWIEDPQEEDKRKIINFVRYELYKKLDTTPAEWDLILPNSSADEIANFRRTFFEGVYVYAEDIRTPFNIGSIFRTAESFGVEKVFLSHDCVSPDSPKAKRTAMGCTEYLPWERADLESLPDLPLIVLETGGTDISKFEFPKKGIVVIGSEELGVSPEAVKKAQGRVITIPMYGIKASINVSVAFGICMQKWCEALTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RR4</accession>
    <name>Q73RR4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-alcohol phosphatidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970638.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680881.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0021"/>
    <dbReference type="EnsemblBacteria" id="AAS10519">
        <property type="protein sequence ID" value="AAS10519"/>
        <property type="gene ID" value="TDE_0021"/>
    </dbReference>
    <dbReference type="GeneID" id="2741636"/>
    <dbReference type="KEGG" id="tde:TDE_0021"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.23"/>
    <dbReference type="eggNOG" id="COG5050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_813633_0_0_12"/>
    <dbReference type="OMA" id="VVILEWI"/>
    <dbReference type="OrthoDB" id="937474at2"/>
    <dbReference type="BioCyc" id="MetaCyc:MON-20237"/>
    <dbReference type="BRENDA" id="2.7.8.2">
        <property type="organism ID" value="6426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="PTHR10414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="333" mass="38502" checksum="4AAC2798D2D35DE7" modified="2004-07-05" version="1">MENYSYSAEDRSLLSPLVYRYFVFPLIKILPESIPANIITIFSNSFVVLSFVVAYLNYLHDTYRFLWLIPIFCWIYIVGDCSDGVQARRTKTGSPLGEYFDHFLDSFVTGLLTGILMLCFRVTNPILLFCVYQFLYLGQIGTFWGRFKDGVMHFSSISTSEGTMVIAIMAALASFSFMRESSLKNIFFTFSIPYIIMFMGFGAAWLTGLIAIFKTKKISIRLVLHLFFSALIGAVLVWKVQAPIFVQTVIITFYNVLFIQSVLSATAEKVKESFPDFLVPISCILYFVAFEYFMIIQVIQIVYLLVRIIIRFLIFFKKYTDCWYWKNPIPSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F7IW18</accession>
    <name>F7IW18_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar hook assembly scaffolding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">flgD</name>
        <name evidence="3" type="ordered locus">TDE_2769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgD family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973367.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666981.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2769"/>
    <dbReference type="EnsemblBacteria" id="AAS13286">
        <property type="protein sequence ID" value="AAS13286"/>
        <property type="gene ID" value="TDE_2769"/>
    </dbReference>
    <dbReference type="GeneID" id="2740736"/>
    <dbReference type="KEGG" id="tde:TDE_2769"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2613"/>
    <dbReference type="eggNOG" id="COG1843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047535_1_0_12"/>
    <dbReference type="OMA" id="PQIMIDG"/>
    <dbReference type="OrthoDB" id="709873at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005648">
        <property type="entry name" value="FlgD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03963">
        <property type="entry name" value="FlgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="169" mass="18689" checksum="731C9D4D7E9F77E6" modified="2011-07-27" version="1">MQVNNVNNSMITTALEQAEMMKDFKSEMSPEEKALLGLQVDTLNKQNFAETRVPKQQLGKDDFLQLLIAQLTHQDPTSPMEDTQFIGQMAQFSSLEQMTNMNKNFAALNELMTGSSAVNAVGKKVDLDLGSSQVSGYISAATRGINPEVMVNGNWYNWSAVKTVYADNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>F7IW68</accession>
    <name>F7IW68_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chemotaxis protein CheA</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cheA</name>
        <name evidence="13" type="ordered locus">TDE_1491</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972097.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671244.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="F7IW68"/>
    <dbReference type="STRING" id="243275.TDE_1491"/>
    <dbReference type="EnsemblBacteria" id="AAS12008">
        <property type="protein sequence ID" value="AAS12008"/>
        <property type="gene ID" value="TDE_1491"/>
    </dbReference>
    <dbReference type="GeneID" id="2739892"/>
    <dbReference type="KEGG" id="tde:TDE_1491"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1430"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_3_6_12"/>
    <dbReference type="OMA" id="MMDMAKS"/>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037052">
        <property type="entry name" value="CheA-like_P2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010808">
        <property type="entry name" value="CheA_P2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035891">
        <property type="entry name" value="CheY-binding_CheA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07194">
        <property type="entry name" value="P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55052">
        <property type="entry name" value="SSF55052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HPt" evidence="12">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="413"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="11">
        <location>
            <begin position="652"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="8">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS12008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="801" mass="88235" checksum="5FA8948C5DE3233A" modified="2011-07-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73IZ2</accession>
    <name>Q73IZ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2785</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973383.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666956.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2785"/>
    <dbReference type="EnsemblBacteria" id="AAS13302">
        <property type="protein sequence ID" value="AAS13302"/>
        <property type="gene ID" value="TDE_2785"/>
    </dbReference>
    <dbReference type="GeneID" id="2739174"/>
    <dbReference type="KEGG" id="tde:TDE_2785"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2628"/>
    <dbReference type="eggNOG" id="COG0762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113320_0_0_12"/>
    <dbReference type="OMA" id="FFRFGIY"/>
    <dbReference type="OrthoDB" id="1981182at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="PTHR33219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="193" mass="22372" checksum="1F76ED884C64447B" modified="2004-07-05" version="1">MISSLFSTLGFAVKIYSYLCIIYIFLSWLGSNSRGGFLYEICEPYLSWFRRFKFTQIGMVDFSPILAIGILSIFAGLLFQIAETRTFSLLRLALTIVSIVWSFFSFLLNFFIIILIIRLVLDFSENYRQGNFADMLDRFLSPVFVRVHKLSGGKFMSLRKQIIVCLIILILIRFLLGAFIGSLSVMFTYFRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J23</accession>
    <name>Q73J23_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM domain/M23/M37 peptidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973351.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680821.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2753"/>
    <dbReference type="EnsemblBacteria" id="AAS13270">
        <property type="protein sequence ID" value="AAS13270"/>
        <property type="gene ID" value="TDE_2753"/>
    </dbReference>
    <dbReference type="GeneID" id="2740720"/>
    <dbReference type="KEGG" id="tde:TDE_2753"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2599"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_7_2_12"/>
    <dbReference type="OMA" id="PYPYLKW"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="178"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="363" mass="39757" checksum="D7F0A819189FCA9F" modified="2004-07-05" version="1">MDIITYSDAVHHNNRSYHSNRYRKPNTVKKSRLSSRDESLIVFGLLAMLTAGFLFFYFPILKLNWGLSSIRSISFWEEPSSINAMRQYTMPSSEIVKEDGLPYSETAEGSSFSPADVPDFITAVDFEEYMVSKGDTVSGIIQKFGLKNLGTLLSVNGISSAKKLRIGQKLIIPSIDGLIYTAVKGDSLSSIAGKFNLSINAILDANDLENQTVSIGQKLFIPGATMSSFELKKALGELFIYPVIGRLTSPFGYRRDPFTGRKSFHTGIDIASPIGTPIKLTLDGTVSYTGYSAVYGNYVIVTHSGGYQSMYGHMNSIKVRRGQILNQGGIIGTVGNTGRSTGPHVHFSVYKDGKLINPLTVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J49</accession>
    <name>Q73J49_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rsgA</name>
        <name evidence="6" type="ordered locus">TDE_2727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973325.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680783.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2727"/>
    <dbReference type="EnsemblBacteria" id="AAS13244">
        <property type="protein sequence ID" value="AAS13244"/>
        <property type="gene ID" value="TDE_2727"/>
    </dbReference>
    <dbReference type="GeneID" id="2740946"/>
    <dbReference type="KEGG" id="tde:TDE_2727"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2575"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_0_1_12"/>
    <dbReference type="OMA" id="RFHDCAH"/>
    <dbReference type="OrthoDB" id="908180at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="99"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="4">
        <location>
            <begin position="107"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="144"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="196"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS13244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="364" mass="41709" checksum="87C199DC96A37486" modified="2004-07-05" version="1">METILNFGFEDFFKDKKIEKEVGRIIFFGGTSYKIICKDVEKEARLKGSFKKECEISGYYPTVGDWIGFESQENSSIALIDFLYERKNKISRTDPRLGIELEQIIAANIDTAFICMSLNKDSNLNRLARYVFALQNIETVLLLTKADLSETREDAENLIKKIYPHLKVYCISIFEPDSLENIKYYFKKGKTSVLLGSSGVGKSSLINSLTGKEILRTSEINKKIDKGVHTTTNRQIISLGEDAGVIMDTPGMKVLGIWDSDSGENSFADITELKSKCLFSDCTHTCEKGCAVLEALKTGLLDKNRYELYLQLLKEDRIKIRREKRQEKFLIKKEEKSKSAKRRFKEKKNIKQTFKKDLDDLLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J90</accession>
    <name>Q73J90_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flagellar synthesis regulator FleN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fleN</name>
        <name evidence="5" type="ordered locus">TDE_2685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AAS13202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680723.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2685"/>
    <dbReference type="EnsemblBacteria" id="AAS13202">
        <property type="protein sequence ID" value="AAS13202"/>
        <property type="gene ID" value="TDE_2685"/>
    </dbReference>
    <dbReference type="GeneID" id="2739272"/>
    <dbReference type="KEGG" id="tde:TDE_2685"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2537"/>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_0_12"/>
    <dbReference type="OMA" id="FKVAKNN"/>
    <dbReference type="OrthoDB" id="1370117at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02038">
        <property type="entry name" value="FlhG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033875">
        <property type="entry name" value="FlhG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="4">
        <location>
            <begin position="35"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="295" mass="32417" checksum="D8705E878C0AD136" modified="2004-07-05" version="1">MTDQAEDLKTLMKNKNSSDKAVLSDLPPKRKSRIIAVTSGKGGVGKTNISTNMAIAYAKMGKNVIVIDADLGLANVNVMMNIIPKFNLYHVMKKQKKMSDIIIDTEYGIKFVAGASGFSKIANMEEAERSDFIKELYTLAEADIIIIDTSAGVSKNVLSFVAAADEVVIVTTSEPTAITDAYGIIKIIATEVENYDLNLKMVVNRVNSALEGKKIAERMIQIVAQFLNLKVEYLGFIYNDPAVEQAVLKQKPFFISAPKSKAASCLRHIVAKLEKTDYNEYSGLSGFLQKLFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JC1</accession>
    <name>Q73JC1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Macrolide efflux protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973252.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680701.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2654"/>
    <dbReference type="EnsemblBacteria" id="AAS13171">
        <property type="protein sequence ID" value="AAS13171"/>
        <property type="gene ID" value="TDE_2654"/>
    </dbReference>
    <dbReference type="GeneID" id="2741099"/>
    <dbReference type="KEGG" id="tde:TDE_2654"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2509"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_16_0_12"/>
    <dbReference type="OMA" id="MGFNITR"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="414" mass="45477" checksum="C9C4DE9954CF3BC9" modified="2004-07-05" version="1">MKTFMVIWFGQFISMLGSALSAFGLGIWIFQKTGSAASFAMSAVCTVLPALLFAPFAGSIADRKKRKAIILLTDSIDAFLKILIVTLLIFNKLELWMVYPLVFISGTLGTFQNPAFGASIPMLVPTDKLTRANGLLQFSSAIQNLLAPVIAGFLYPLIELKGLFIIDFVSFFFALASIAFIKIPQPLIEKTKDSLVLAALKDLKYAWKYLIQKEGLMQLIVFFAFLNFIANLSMILLGPLMMSVYNSQVYGNVQAGIGLAMLLGGLCSSLIPDTKNKIKRILLILALCSIGPIISGATLNWIIITAGFFIFMFPVPYVNTLLMSIFQIKIERNVLGRVGALMTAILTAITPIAYLCAGPLADYVFEPLMNEKGRGIGLIFIISGILLIISCFLMRLNKTVTSIEKRLPDYVDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JC7</accession>
    <name>Q73JC7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973246.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680689.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2648"/>
    <dbReference type="EnsemblBacteria" id="AAS13165">
        <property type="protein sequence ID" value="AAS13165"/>
        <property type="gene ID" value="TDE_2648"/>
    </dbReference>
    <dbReference type="GeneID" id="2741093"/>
    <dbReference type="KEGG" id="tde:TDE_2648"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2503"/>
    <dbReference type="eggNOG" id="ENOG5031VZY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1194453_0_0_12"/>
    <dbReference type="OrthoDB" id="2121811at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="231" mass="26721" checksum="FA80AB05A31F5FDA" modified="2004-07-05" version="1">MKKTKAIIFNSMHSVNFVLSGIFCLIGFIEMIIGILIPIPLAMKILFFQGLIFFCYGLIINQLSLYDQILVFILTPVRGKEFFKVKLIYSIFTSFFALMFLGLILFLINIFTPIWDLKFMIFIGSVLFPFIIAFSMILSALSIKGGLLRFIIIMTVGYGLFPSLSMMMISDLPNLELIKSFFERVSYPLFILAVYIISLVIILISYFIGKRNFNKFRFKSFMIMNQRNRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JI3</accession>
    <name>Q73JI3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973034.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2435"/>
    <dbReference type="EnsemblBacteria" id="AAS12953">
        <property type="protein sequence ID" value="AAS12953"/>
        <property type="gene ID" value="TDE_2435"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2435"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2303"/>
    <dbReference type="eggNOG" id="ENOG50348SD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1377588_0_0_12"/>
    <dbReference type="OMA" id="MSAKEND"/>
    <dbReference type="OrthoDB" id="1216113at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="198" mass="22173" checksum="A6A3D1024873FFD9" modified="2004-07-05" version="1">MQNKERELFAAVDYILNRAGEREIEVIAAALERKKNEASAASPLAAINPENMAKQMSESINKSIQASLEGVRHTFRDFAADMLLKEAPELSEDQMKALIDSWIPEQGSYDGKIKSLAKNGKVDGVPADVLYGMILQFVSYSIGEMSAKENDELKTAMGNWTEKYWSRFPMRVKEEIKSFINGEITSGEFRKNITALIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JJ9</accession>
    <name>Q73JJ9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2807 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973018.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680357.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2419"/>
    <dbReference type="EnsemblBacteria" id="AAS12937">
        <property type="protein sequence ID" value="AAS12937"/>
        <property type="gene ID" value="TDE_2419"/>
    </dbReference>
    <dbReference type="GeneID" id="2739844"/>
    <dbReference type="KEGG" id="tde:TDE_2419"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2285"/>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072746_2_1_12"/>
    <dbReference type="OMA" id="NAQRVIT"/>
    <dbReference type="OrthoDB" id="1418315at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021255">
        <property type="entry name" value="DUF2807"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10988">
        <property type="entry name" value="DUF2807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284542" description="DUF2807 domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2807" evidence="2">
        <location>
            <begin position="50"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="248" mass="25979" checksum="17F625E1BC4B0F73" modified="2004-07-05" version="1">MNKVKVIGVVKASVITALLCICISCQSFSDSGEVIKGNGKIETKSFPQNNFNALSISGGWIADIRYSETFSIQIETDENIFPDLDISVAGTTLNIGFKSGYSISPTQCKVSITMPALIKLQTVGSLTAVISSFNMPKDSMSIDISGSGNITARDITVNTLKVDVSGSADFSATGKAKNIIADISGSGDIKTTDFETEKADISISGSGSAKVWVTRHLKADIGASGSIRYKGNPVIETKSSGSGRISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JK3</accession>
    <name>Q73JK3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973014.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680352.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2415"/>
    <dbReference type="EnsemblBacteria" id="AAS12933">
        <property type="protein sequence ID" value="AAS12933"/>
        <property type="gene ID" value="TDE_2415"/>
    </dbReference>
    <dbReference type="GeneID" id="2739840"/>
    <dbReference type="KEGG" id="tde:TDE_2415"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2281"/>
    <dbReference type="eggNOG" id="ENOG50302KV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099014_0_0_12"/>
    <dbReference type="OrthoDB" id="1847310at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024211">
        <property type="entry name" value="DUF3841"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12952">
        <property type="entry name" value="DUF3841"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="210" mass="25204" checksum="3DB390EDBC5DF76A" modified="2004-07-05" version="1">MKHKKNPYTKNGKTLLFTCQDKRSLDILEKTGLFLNKRIYIEEHLAGISSLMLKCYDWFIKESSKRIKKPDYADYHIWCSVSAKSCMRPEEGNVAYILEVPNEEILYFSGFKWDYVLNLHYVPENEADLAAYEEDIKQKGFKNSYEFINGRYARMFPDEEKRVRDSWLRVFDIDDWNIFDVQANIWHIKKEWVKQVIRPGERIPEHFVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JN9</accession>
    <name>Q73JN9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973042.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680385.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2443"/>
    <dbReference type="EnsemblBacteria" id="AAS12961">
        <property type="protein sequence ID" value="AAS12961"/>
        <property type="gene ID" value="TDE_2443"/>
    </dbReference>
    <dbReference type="GeneID" id="2739628"/>
    <dbReference type="KEGG" id="tde:TDE_2443"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2311"/>
    <dbReference type="HOGENOM" id="CLU_2686716_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284889" evidence="1">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="74" mass="8493" checksum="227577A15476867C" modified="2004-07-05" version="1">MKKMLSFLFMFALFGVLVKGQRMTPSGQYQYHSDYFKVNASSAKEAEAIAEGKYNAKFRGYFKIISSKATELKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JV2</accession>
    <name>Q73JV2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973107.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680476.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2509"/>
    <dbReference type="EnsemblBacteria" id="AAS13026">
        <property type="protein sequence ID" value="AAS13026"/>
        <property type="gene ID" value="TDE_2509"/>
    </dbReference>
    <dbReference type="GeneID" id="2739021"/>
    <dbReference type="KEGG" id="tde:TDE_2509"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2375"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052345_0_0_12"/>
    <dbReference type="OMA" id="CIDHCRE"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="189"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="294" mass="34849" checksum="C7FA6B74B6E3731E" modified="2004-07-05" version="1">MKEKTKDDTIIIKLYEGIHLEIYDTYTEKSYSLKGEPRNVFRIDYCFQGLLEGKFENQTFSYLGEKETAINYEKVALSKSFFPLKFYKGISILFFLDKINSNFKNTAQLFNIDIEKICKNLDLQDGWYKIKINSEISYIMNTLYEKQSLKHIEYFQIKLFEILYLLSVINTEEYQKEEFYSGYHINKVKKIHEYAVNNIDKNISFKKMVKNEDLSYTIFQKLFKQIYGESPYSYLKKYRLEIAAFYISSTDRKITDIAINCGYLNASKFSDAFKSVYGISPIQYRNGEKPTITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JY4</accession>
    <name>Q73JY4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973127.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680497.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2529"/>
    <dbReference type="EnsemblBacteria" id="AAS13046">
        <property type="protein sequence ID" value="AAS13046"/>
        <property type="gene ID" value="TDE_2529"/>
    </dbReference>
    <dbReference type="GeneID" id="2739041"/>
    <dbReference type="KEGG" id="tde:TDE_2529"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2393"/>
    <dbReference type="eggNOG" id="COG4095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163406_1_0_12"/>
    <dbReference type="OMA" id="CTLWVAY"/>
    <dbReference type="OrthoDB" id="1844907at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_sugar_transpr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS13046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="86" mass="9475" checksum="C3A5CD13CD5E00EC" modified="2004-07-05" version="1">MNSKFFAVLGWVATATAMAMYVSYIPQISNNLSGMKGNWLQPLVAAINCVLWVTYGLMKKPKRDWPIAFANSPGIFFGLVAFITAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K02</accession>
    <name>Q73K02_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973161.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673727.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2563"/>
    <dbReference type="EnsemblBacteria" id="AAS13080">
        <property type="protein sequence ID" value="AAS13080"/>
        <property type="gene ID" value="TDE_2563"/>
    </dbReference>
    <dbReference type="GeneID" id="2739928"/>
    <dbReference type="KEGG" id="tde:TDE_2563"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2422"/>
    <dbReference type="eggNOG" id="ENOG5032EZN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2866489_0_0_12"/>
    <dbReference type="OrthoDB" id="2066449at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="64" mass="7239" checksum="021DFE44CBE268F3" modified="2004-07-05" version="1">MSDALTQVENQVLSFSLAEQIRLLTFIANNVNKQTSILAEGEALKKIRESSLETVWESIKNDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K35</accession>
    <name>Q73K35_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GGDEF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973180.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2582"/>
    <dbReference type="EnsemblBacteria" id="AAS13099">
        <property type="protein sequence ID" value="AAS13099"/>
        <property type="gene ID" value="TDE_2582"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2582"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2442"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_242103_0_0_12"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1431" mass="164160" checksum="452B61ABBC295507" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K47</accession>
    <name>Q73K47_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972974.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667688.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2375"/>
    <dbReference type="EnsemblBacteria" id="AAS12893">
        <property type="protein sequence ID" value="AAS12893"/>
        <property type="gene ID" value="TDE_2375"/>
    </dbReference>
    <dbReference type="GeneID" id="2739984"/>
    <dbReference type="KEGG" id="tde:TDE_2375"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2243"/>
    <dbReference type="HOGENOM" id="CLU_174891_0_0_12"/>
    <dbReference type="OMA" id="FLMYISI"/>
    <dbReference type="OrthoDB" id="2043841at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="105" mass="12118" checksum="1F5ED47482834BC5" modified="2004-07-05" version="1">MNDLVKFLSEGYPILLFTKLFLGAVAVFFAIIVWSKTKRLSMILFVLGMFLMYISILTDTLTYFGFINTKFFTIGSLPLLSIIFENAPIVFFIASFCVFLRERIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K68</accession>
    <name>FLIW_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flagellar assembly factor FliW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fliW</name>
        <name type="ordered locus">TDE_2354</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with translational regulator CsrA and flagellin(s).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FliW family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972953.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674247.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73K68"/>
    <dbReference type="SMR" id="Q73K68"/>
    <dbReference type="STRING" id="243275.TDE_2354"/>
    <dbReference type="EnsemblBacteria" id="AAS12872">
        <property type="protein sequence ID" value="AAS12872"/>
        <property type="gene ID" value="TDE_2354"/>
    </dbReference>
    <dbReference type="GeneID" id="2739963"/>
    <dbReference type="KEGG" id="tde:TDE_2354"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2222"/>
    <dbReference type="eggNOG" id="COG1699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112356_0_2_12"/>
    <dbReference type="OMA" id="DVAVFCI"/>
    <dbReference type="OrthoDB" id="1767625at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01185">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003775">
        <property type="entry name" value="Flagellar_assembly_factor_FliW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024046">
        <property type="entry name" value="Flagellar_assmbl_FliW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39190">
        <property type="entry name" value="PTHR39190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02623">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141457">
        <property type="entry name" value="SSF141457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_0000273013" description="Flagellar assembly factor FliW">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01185"/>
        </source>
    </evidence>
    <sequence length="147" mass="16604" checksum="9F44643ED5FA71F3" modified="2004-07-05" version="1">MEIKTKAMGLVEIQDEQIIELVDGFYGFEEFHKYALLDSGKEPFFWVQSLDDQNLAFIVIDPFLFRPDYELDIDDELLKPIEAESPKDLLVFALVTIPPAGSPITANLQGPLIINKKNKKAFQAVLNDGKWNTKHDILAELNAAGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K95</accession>
    <name>Q73K95_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972924.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957210.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73K95"/>
    <dbReference type="STRING" id="243275.TDE_2324"/>
    <dbReference type="EnsemblBacteria" id="AAS12843">
        <property type="protein sequence ID" value="AAS12843"/>
        <property type="gene ID" value="TDE_2324"/>
    </dbReference>
    <dbReference type="GeneID" id="2739419"/>
    <dbReference type="KEGG" id="tde:TDE_2324"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2193"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_10_12"/>
    <dbReference type="OMA" id="LDRFAPM"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="150"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="217" mass="24196" checksum="12A810904551DA00" modified="2004-07-05" version="1">MRIAIVDDEKLICEGLKIIFQSYPDIEVIATGSNGNDALKICEEKNPELLLMDIRMPECNGVEATKKIKKSFSDIKILILTTFNDTEYIQKALQYGASGYLLKDSSPDVIYDGIKAAISGNIVINPEVAKTMLFENHEEAEERVIRPLAEIQDEFGLSQKEIEIIRLVSEGLSNKQIAYKQGLSEGTIKNNISVIFDKTFVSDRTQLAAFAFKNGIV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KC6</accession>
    <name>ISPF_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="1">MECDP-synthase</shortName>
            <shortName evidence="1">MECPP-synthase</shortName>
            <shortName evidence="1">MECPS</shortName>
            <ecNumber evidence="1">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispF</name>
        <name type="ordered locus">TDE_2292</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspF family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972892.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680204.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KC6"/>
    <dbReference type="SMR" id="Q73KC6"/>
    <dbReference type="STRING" id="243275.TDE_2292"/>
    <dbReference type="EnsemblBacteria" id="AAS12811">
        <property type="protein sequence ID" value="AAS12811"/>
        <property type="gene ID" value="TDE_2292"/>
    </dbReference>
    <dbReference type="GeneID" id="2740257"/>
    <dbReference type="KEGG" id="tde:TDE_2292"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2162"/>
    <dbReference type="eggNOG" id="COG0245">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084630_2_0_12"/>
    <dbReference type="OMA" id="QHFGTGR"/>
    <dbReference type="OrthoDB" id="1716560at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000189513" description="2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <sequence length="161" mass="17768" checksum="D05D8BC5ECBB1368" modified="2004-07-05" version="1">MRTGLGYDLHRLVRGKKLMMGGVHIPFKKGEKAHSDGDVLLHAITDALLGACGMGDIGEFFPPSDKKWKDANSSELLSTVWERISEAGWKIQNIDCVIIIEEPKILPFREEIRKSIAGILKIEKEQIFIKAKTGEGIGIIGRGKAVAALASCLIFCRHTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KF7</accession>
    <name>Q73KF7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972861.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2261"/>
    <dbReference type="EnsemblBacteria" id="AAS12780">
        <property type="protein sequence ID" value="AAS12780"/>
        <property type="gene ID" value="TDE_2261"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2261"/>
    <dbReference type="HOGENOM" id="CLU_3391915_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="32" mass="3815" checksum="6C8BB3C243DDED69" modified="2004-07-05" version="1">MKLQQRLSCAQINLQSNTDKFTHIKNRKERQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KH0</accession>
    <name>Q73KH0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HesA/MoeB/ThiF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972848.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680109.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2248"/>
    <dbReference type="EnsemblBacteria" id="AAS12767">
        <property type="protein sequence ID" value="AAS12767"/>
        <property type="gene ID" value="TDE_2248"/>
    </dbReference>
    <dbReference type="GeneID" id="2741353"/>
    <dbReference type="KEGG" id="tde:TDE_2248"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2122"/>
    <dbReference type="eggNOG" id="COG1179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_4_1_12"/>
    <dbReference type="OMA" id="DMDDICV"/>
    <dbReference type="OrthoDB" id="1543144at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="10"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="240" mass="26359" checksum="ACF593690F8AD593" modified="2004-07-05" version="1">MSFLSRFEPLLGSENLKKIEDARIAVFGLGGVGSYTAEALARSGVARNGAGQLILIDGDEIEESNINRQLYALYSTIGKAKTEIAMERIADINPACKIEAVNSFILPDNFYKILGEDFFKRVDFIVDAVDTIALKIFLAAEAEKNEVPIISAMGCGNRLNADFEFADIYKTSVCPLCKVMRTELKKRNVKYLKVLYSKTECTVKQNPPASAAWVPSIAGLLIAGEVIKSLYQPASFKETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KQ3</accession>
    <name>Q73KQ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972765.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680004.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2164"/>
    <dbReference type="EnsemblBacteria" id="AAS12684">
        <property type="protein sequence ID" value="AAS12684"/>
        <property type="gene ID" value="TDE_2164"/>
    </dbReference>
    <dbReference type="GeneID" id="2739150"/>
    <dbReference type="KEGG" id="tde:TDE_2164"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2045"/>
    <dbReference type="eggNOG" id="ENOG5031CW2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093869_0_0_12"/>
    <dbReference type="OMA" id="VCEISCA"/>
    <dbReference type="OrthoDB" id="1475267at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284575" evidence="1">
        <location>
            <begin position="22"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="235" mass="25764" checksum="43F9A07DCD6A16C7" modified="2004-07-05" version="1">MKYIKTIMFVLIAGLVLTACAPKADVFVQASGDVVVTLDIQTGKTIDALLENAAQFTEEEKAKSPSIFNIEEIKQQLESKGIKVLNMTTNSIAGINAKIKIMNKDMDSESSFVKTDMKTGLLSLSIGPDNIKEFVNLLSEDDREYIELLMAPAITGEPIGTAEYEELIKAAYGDKLVSDLKKSKFHVSITCPKKIKSIKITPFGHSSKDGNKGTVDIPLSELLCVRDPIFVEVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L01</accession>
    <name>Q73L01_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeoA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972667.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679859.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2065"/>
    <dbReference type="EnsemblBacteria" id="AAS12578">
        <property type="protein sequence ID" value="AAS12578"/>
        <property type="gene ID" value="TDE_2065"/>
    </dbReference>
    <dbReference type="GeneID" id="2741192"/>
    <dbReference type="KEGG" id="tde:TDE_2065"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1949"/>
    <dbReference type="eggNOG" id="ENOG5031D77">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150646_6_3_12"/>
    <dbReference type="OrthoDB" id="1975706at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="87" mass="9495" checksum="FE1DAB3C57EC19C5" modified="2004-07-05" version="1">MVVTTFCERLLTLVPLIILKEGDKASVLKFDGTGAEFSRLRSLGIDINTEITVVTSQADKKGPILLLVNGSKYAVDYNLASKILVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L17</accession>
    <name>Q73L17_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterial extracellular solute-binding proteins, family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972651.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2049"/>
    <dbReference type="EnsemblBacteria" id="AAS12562">
        <property type="protein sequence ID" value="AAS12562"/>
        <property type="gene ID" value="TDE_2049"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2049"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1935"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_0_3_12"/>
    <dbReference type="OMA" id="SSWGDPQ"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285944" evidence="3">
        <location>
            <begin position="20"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="68"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="530" mass="60441" checksum="3B251B15D727FE28" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L46</accession>
    <name>Q73L46_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972622.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2019"/>
    <dbReference type="EnsemblBacteria" id="AAS12533">
        <property type="protein sequence ID" value="AAS12533"/>
        <property type="gene ID" value="TDE_2019"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2019"/>
    <dbReference type="HOGENOM" id="CLU_2572853_0_0_12"/>
    <dbReference type="OrthoDB" id="2206810at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="81" mass="9844" checksum="FAE2EBCD29366F96" modified="2004-07-05" version="1">MINSSAQMVPLYLSAEFAFRQTSHYYMCFFTSLQKHGKNFFRKLRLPAKSFYGRLNNENVKEYDFYFYVGSFGFMYKKRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L77</accession>
    <name>Q73L77_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972591.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1988"/>
    <dbReference type="EnsemblBacteria" id="AAS12502">
        <property type="protein sequence ID" value="AAS12502"/>
        <property type="gene ID" value="TDE_1988"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1988"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1877"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306939_0_0_12"/>
    <dbReference type="OMA" id="MEGSCKK"/>
    <dbReference type="OrthoDB" id="485474at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285825" evidence="1">
        <location>
            <begin position="27"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="923" mass="104837" checksum="183D6BBF246A5796" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L87</accession>
    <name>Q73L87_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972581.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679713.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1978"/>
    <dbReference type="EnsemblBacteria" id="AAS12492">
        <property type="protein sequence ID" value="AAS12492"/>
        <property type="gene ID" value="TDE_1978"/>
    </dbReference>
    <dbReference type="GeneID" id="2741541"/>
    <dbReference type="KEGG" id="tde:TDE_1978"/>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155761_1_1_12"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="85" mass="10014" checksum="66C342AC80AAA090" modified="2004-07-05" version="1">MKVILTETFKKQLKKLDAAISKRVLDYLEQIELLDNPRSRGKALTSNLSGLWRYRVGNYRILCRIHDDRLIITVIEIGHRSTVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LB5</accession>
    <name>Q73LB5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane lipoprotein TmpC, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972553.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669780.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73LB5"/>
    <dbReference type="STRING" id="243275.TDE_1950"/>
    <dbReference type="EnsemblBacteria" id="AAS12464">
        <property type="protein sequence ID" value="AAS12464"/>
        <property type="gene ID" value="TDE_1950"/>
    </dbReference>
    <dbReference type="GeneID" id="2740190"/>
    <dbReference type="KEGG" id="tde:TDE_1950"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1842"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_0_2_12"/>
    <dbReference type="OMA" id="DASQEWY"/>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bmp" evidence="7">
        <location>
            <begin position="32"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="357" mass="38444" checksum="DDC1AE20A936BC03" modified="2004-07-05" version="1">MKNIVKIFIGCLLILGVLTSCSKEEGKKALMVGMVTDAGTIDDKSFNQGTWEGIKKAESDLGVKVKYLKPVGTTEADYIKEISNLYDSGYKFIICPGFKFETAVFKAQSKYKDAKFIIIDGNAHPADAYDAQNGPNTIGISFLENEAGFLAGVAAALQQKTGNFGFIGGMEIPAVQKFNWGWQQGIKYANENLGTQIEIYPENFIYQGGFSDIAAGQQIAASMYDRGVTVIHAAAGGVGVGVINEAKTRTQAGKKVWVVGVDVDQYAEGVIADGSSIILTSAMKYLDKASYDMIKEELNGTFAGGRSLLFSVKENGVGIPAKNPNLSDDVQQKVNEIYQKIKNGEIVVSATQGDLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LC5</accession>
    <name>Q73LC5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972543.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679657.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1940"/>
    <dbReference type="EnsemblBacteria" id="AAS12454">
        <property type="protein sequence ID" value="AAS12454"/>
        <property type="gene ID" value="TDE_1940"/>
    </dbReference>
    <dbReference type="GeneID" id="2740180"/>
    <dbReference type="KEGG" id="tde:TDE_1940"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1833"/>
    <dbReference type="eggNOG" id="ENOG5031BYU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794406_0_0_12"/>
    <dbReference type="OMA" id="HIEINIV"/>
    <dbReference type="OrthoDB" id="1280739at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285957" evidence="1">
        <location>
            <begin position="25"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="354" mass="40604" checksum="FBC03C8C602DA187" modified="2004-07-05" version="1">MKNKFILLLLCVLMVFVSCSTIQKDSIYSTTLSQDNIRNVEHIEINIVRQYRENNQEKIEDIKKDLNALLAVPSSDRSYLALVYALYADYFLLNRDKVSAKKMLKTAESYNPHEEYVHLVKSRLTDKLEDKKDYLISMIKLNPRAYRLQSELGFVYYLLEDYTRALVAFDASLDFLNEEYGLLYGEKREYCRKFYKVDSDVKNSTAQILTQSKISLIDMTTLTQDNTHALDSITGTAFWRPAMLADRLKAAGWYADSVNISKGTATRKDAALFLWHLLIGNDNEALTQYSRQYVYSGKSSPIQDVAIDGVFFDAIIGLVEEDIIPLIDGRLFVPDGDVSGLDFYEWLKKADGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LE3</accession>
    <name>Q73LE3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972525.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1922"/>
    <dbReference type="EnsemblBacteria" id="AAS12436">
        <property type="protein sequence ID" value="AAS12436"/>
        <property type="gene ID" value="TDE_1922"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1922"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1819"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071023_2_2_12"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="190" mass="22252" checksum="CDFCBDAEA4402F84" modified="2004-07-05" version="1">MQAENGKLYDVEMQVSNELNIPKRMRFYQAAIDISFLDKGNSYNSLNDSFIIFICTFDAIGKNRPVYTFENLCIEDKNTPLQDGTRKVIINAEGFNNTEEKELKEFLEYLKTGKPNNEFTMEIEKMIQTVKNNEQARQEYRLLSTFEMDIKDKAEYRVKRETAKLMKQRGYPISEILLMTGLPESEIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LH4</accession>
    <name>Q73LH4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Branched-chain amino acid transport system II carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">brnQ</name>
        <name evidence="9" type="ordered locus">TDE_1889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the branched chain amino acid transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972492.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669699.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1889"/>
    <dbReference type="EnsemblBacteria" id="AAS12403">
        <property type="protein sequence ID" value="AAS12403"/>
        <property type="gene ID" value="TDE_1889"/>
    </dbReference>
    <dbReference type="GeneID" id="2739118"/>
    <dbReference type="KEGG" id="tde:TDE_1889"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1790"/>
    <dbReference type="eggNOG" id="COG1114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036807_0_2_12"/>
    <dbReference type="OMA" id="IWPAGPI"/>
    <dbReference type="OrthoDB" id="1533843at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004685">
        <property type="entry name" value="Brnchd-chn_aa_trnsp_Livcs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30588">
        <property type="entry name" value="PTHR30588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05525">
        <property type="entry name" value="Branch_AA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00796">
        <property type="entry name" value="livcs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="462" mass="49979" checksum="44113F3720F05A7B" modified="2004-07-05" version="1">MSKKTTDIIVIGFALFAMFLGAGNLIFPPTLGHLSGKDWIFSLLGFLVTGVGMPVLGIISMGKCDGHLSNFTKNINQLFGTFFIIFVMLIIGPLFAIPRTAATTYEIAIRPNFGISSVLSSFIFFAITLFFVLTPNNVIDRVGKFLTPALIAVLGLLVIKGFITPIGRPSDPSVDKIFLRGFKEGYQTMDALGSMILATIVISSISAKGYTEKKSLLKMTIWTGLIACIGLGLVYGGLVYVGATGSAVLPDNLSRTEIVVQSSEILWGRGGRIVLGLAIGLACLTTSIGLTATAGEYFSKRFKDDISYRATVIIICVVSFFLSNFGVDNIISIAGPILEIIYPVAIVLIVLNLFAEFIPNKYFFHGAVIGTLSISILQGWVAAQELINNLLIKLEAFPAMDQVGMSFNTTINVLKTLPFEGIGFPWLLPALGLSLLFGFGYIIMQKTEKAPSMKRESQKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LJ0</accession>
    <name>Q73LJ0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972476.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1872"/>
    <dbReference type="EnsemblBacteria" id="AAS12387">
        <property type="protein sequence ID" value="AAS12387"/>
        <property type="gene ID" value="TDE_1872"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1872"/>
    <dbReference type="HOGENOM" id="CLU_3298097_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="40" mass="4854" checksum="57AB785C0E4A956B" modified="2004-07-05" version="1">MLNKIEIFINFVNLRLMGEILYDRLKLDIEGKYKLKEIIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LJ9</accession>
    <name>RUVA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvA</name>
        <name type="ordered locus">TDE_1863</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972467.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679554.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73LJ9"/>
    <dbReference type="SMR" id="Q73LJ9"/>
    <dbReference type="STRING" id="243275.TDE_1863"/>
    <dbReference type="PRIDE" id="Q73LJ9"/>
    <dbReference type="EnsemblBacteria" id="AAS12378">
        <property type="protein sequence ID" value="AAS12378"/>
        <property type="gene ID" value="TDE_1863"/>
    </dbReference>
    <dbReference type="GeneID" id="2740052"/>
    <dbReference type="KEGG" id="tde:TDE_1863"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1768"/>
    <dbReference type="eggNOG" id="COG0632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087936_2_0_12"/>
    <dbReference type="OMA" id="VGMAVQC"/>
    <dbReference type="OrthoDB" id="1370858at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000224921" description="Holliday junction ATP-dependent DNA helicase RuvA">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <sequence length="201" mass="22054" checksum="0070BAF3F2D78C58" modified="2004-07-05" version="1">MFNSISGILSGKTTDSVYVENSGIEWEIFVSALALDALGTVGKEVKVYTWLYHREDQMRLFGFPNQAERSLFLDLTKVEGVGPRQALKIMSGLNSSSLEKALEEGDLDTLQKAPGVGKKTAQKMILALKGKLTNLNEVSSKGQASVSCEYEDIVTALTEMGFERKSVIVQVEKIAEEMKAAGSDPLKNEEELFRRSIVALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LK5</accession>
    <name>Q73LK5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2147 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972461.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669617.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1857"/>
    <dbReference type="EnsemblBacteria" id="AAS12372">
        <property type="protein sequence ID" value="AAS12372"/>
        <property type="gene ID" value="TDE_1857"/>
    </dbReference>
    <dbReference type="GeneID" id="2740046"/>
    <dbReference type="KEGG" id="tde:TDE_1857"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1762"/>
    <dbReference type="eggNOG" id="COG4731">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108869_0_1_12"/>
    <dbReference type="OMA" id="WGIGQKP"/>
    <dbReference type="OrthoDB" id="1848240at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019223">
        <property type="entry name" value="DUF2147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09917">
        <property type="entry name" value="DUF2147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284588" description="DUF2147 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2147" evidence="2">
        <location>
            <begin position="26"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="173" mass="19634" checksum="5AA074C8A95785A7" modified="2004-07-05" version="1">MKKIILITLFFMCILAMGFSEDPATGLWKSVDEKTNEVTGVWNIYEKDGKLFGEMLVTVGHDPKELASSCKESYKDFPKAGKVNEMPLVGTPFIYGLVKKETGSWHKGYIIDPGDGKYYYCKIKFHKADGKKFKTDTLEMRGEIGLGIGRSQYWLRTDKAETDELIKNNVVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LQ0</accession>
    <name>Q73LQ0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972416.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002689021.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1812"/>
    <dbReference type="EnsemblBacteria" id="AAS12327">
        <property type="protein sequence ID" value="AAS12327"/>
        <property type="gene ID" value="TDE_1812"/>
    </dbReference>
    <dbReference type="GeneID" id="2739242"/>
    <dbReference type="KEGG" id="tde:TDE_1812"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1722"/>
    <dbReference type="eggNOG" id="ENOG5033EAK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169602_0_0_12"/>
    <dbReference type="OrthoDB" id="2009568at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="91" mass="10880" checksum="C1373E4B990693C8" modified="2004-07-05" version="1">MEESTFDKYIKNDIKQKKKFDKEYNNFLLSEFILEKMEEENISVRELARKAEVSPTIIQKLRNNKTADKINYQTFLSVVNSLGYRVNIERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LQ7</accession>
    <name>Q73LQ7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1805</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972409.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957056.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1805"/>
    <dbReference type="EnsemblBacteria" id="AAS12320">
        <property type="protein sequence ID" value="AAS12320"/>
        <property type="gene ID" value="TDE_1805"/>
    </dbReference>
    <dbReference type="GeneID" id="2739235"/>
    <dbReference type="KEGG" id="tde:TDE_1805"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1717"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049058_0_0_12"/>
    <dbReference type="OMA" id="FRWKCFQ"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="273" mass="31483" checksum="C608E0BB6DB98679" modified="2004-07-05" version="1">MYNSKQFLRTVNWHFVNSCNMSCKYCFVSCCKELPLEESISVLEKLKGHFDRINFVGGEPTVSSKLIPLVKKAKEYGFIVSMVTNGFNLYHKPETFDEILTDFSIIGISIDSLNENTNVLIGRSVKNSVLSRDDYIDLCKKIKLAGCKLKINTVVSRVNLDENFNDFYETVMPDRIKLLQVLRPAGRLKQDYTDFLIEEDDYLEFVQRHHKFSEVICSENNELMLNSYYILNSDACFLDNKSGCISGSLLENDLKSVLKNVYVDENKYRARYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LT6</accession>
    <name>Q73LT6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972380.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679531.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12291">
        <property type="protein sequence ID" value="AAS12291"/>
        <property type="gene ID" value="TDE_1776"/>
    </dbReference>
    <dbReference type="GeneID" id="2741220"/>
    <dbReference type="KEGG" id="tde:TDE_1776"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1692"/>
    <dbReference type="HOGENOM" id="CLU_1022852_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="272" mass="32125" checksum="9B27D4121983C6C9" modified="2004-07-05" version="1">MNIYENLATQAITSFFYNEALWKKEIVFDFLLKPFNLQLLDIAEVKAQDNLKGTVPDFTIITKNSEKLRYEVKINNSGLTISEYDKDTRDAYLIRKNYSFREEIPIPKDKILFWEDLFEIIDKKGATTDFTRFDLIREYMCEDIHTLLFTPHEVAMLYSPDTIIAVYEMKEKLLEICRKFLDANVTKYEYKGKLDSKYGIGCYFKKKGAPEYDLFIGLSPHAEKYYSIAKYISGDNWDYFELDKEILAKCNTEEELQQEFNKNAEDVMLKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M58</accession>
    <name>Q73M58_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972257.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679338.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1651"/>
    <dbReference type="EnsemblBacteria" id="AAS12168">
        <property type="protein sequence ID" value="AAS12168"/>
        <property type="gene ID" value="TDE_1651"/>
    </dbReference>
    <dbReference type="GeneID" id="2738992"/>
    <dbReference type="KEGG" id="tde:TDE_1651"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1577"/>
    <dbReference type="eggNOG" id="COG1268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077931_1_1_12"/>
    <dbReference type="OMA" id="AGYLWSY"/>
    <dbReference type="OrthoDB" id="1691691at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="203" mass="21471" checksum="96372F3E58FECBC2" modified="2004-07-05" version="1">MSSNFKLSIMPIFVPLFAALIAVSGFIAFPLPGTPVPIVLQNMMPILASGLLGGLYGTASTALFLIAGLLGLPVFSGGRGGLAHLLGPTGGFLIGYLAAAAFLIIFFRKPGAKDLALVSSGKNNSIKLINYLKIIAASFSGFALIYVFGIARFMQLTNRGLFESLSLACIPYLPGDFIKMILVSALIYKLRPVTARYFLEASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M69</accession>
    <name>Q73M69_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Shikimate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="3">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972246.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679324.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1640"/>
    <dbReference type="EnsemblBacteria" id="AAS12157">
        <property type="protein sequence ID" value="AAS12157"/>
        <property type="gene ID" value="TDE_1640"/>
    </dbReference>
    <dbReference type="GeneID" id="2739749"/>
    <dbReference type="KEGG" id="tde:TDE_1640"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1568"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019120_1_1_12"/>
    <dbReference type="OMA" id="TTSVGME"/>
    <dbReference type="OrthoDB" id="1054867at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="Shikimate_dh_N" evidence="6">
        <location>
            <begin position="241"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate_DH" evidence="5">
        <location>
            <begin position="350"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="493" mass="55501" checksum="A6A272F4083F5BA9" modified="2004-07-05" version="1">MSTKVCLVLTEKTIEKNLSALEKYKKFIDIAELRVDYLNQSEILYLRNFPERAGIPCILTVRRKSDGGNFTGGEGARMTIFARGLAFANADPIKNFSYIDLESDFDSSGIEEAARAFDIKIIRSLHSKVPVKNIVKTVEGLSRFETDIPKLAFTANCLNDVSELFKASKLIKNQEYILSVMGPYGLSSRILSNKLNSQIVYTFTPEYIKKNKLEQELIDPETLEELYGFSKIDEETSLYGVIGKDVNTSLSPQIHNKGFKRKNLNSVYIPISAVSSKEALDFANLLKIKGLSVTAPFKSEIIPLINSISEASKFIGAVNTLVSENKKWFGYNTDVDGFQQALMEFLNEKDLRKYKVAIIGAGGAARAVAEVISSLHGKACIFNRTAEKAKNIAEKYKFKWALLDPINIKQLHAFSELIIQTTNAGMEPDIYMDPLNFYTFTGKEKVFELIYRPETTKMLKRARTAGCQVCNGYKMLEYQAYHQFKAFAGKEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M75</accession>
    <name>Q73M75_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972240.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679318.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1634"/>
    <dbReference type="EnsemblBacteria" id="AAS12151">
        <property type="protein sequence ID" value="AAS12151"/>
        <property type="gene ID" value="TDE_1634"/>
    </dbReference>
    <dbReference type="GeneID" id="2739743"/>
    <dbReference type="KEGG" id="tde:TDE_1634"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1562"/>
    <dbReference type="eggNOG" id="COG3514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140900_2_0_12"/>
    <dbReference type="OrthoDB" id="1855549at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025528">
        <property type="entry name" value="BrnA_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14384">
        <property type="entry name" value="BrnA_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="92" mass="10637" checksum="A0E76A88256B1E6C" modified="2004-07-05" version="1">MNTIVTMTLDDLKKTPLTEEEKQTIRKAKSIPTDDCPKQSKEELAKFRPWYEVHQKSETSIKIDADVLEWFKAQGKGYKTKINAVLRSYAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MC6</accession>
    <name>Q73MC6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972189.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1583"/>
    <dbReference type="EnsemblBacteria" id="AAS12100">
        <property type="protein sequence ID" value="AAS12100"/>
        <property type="gene ID" value="TDE_1583"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1583"/>
    <dbReference type="HOGENOM" id="CLU_3318660_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="39" mass="4446" checksum="1C62A515379B65A1" modified="2004-07-05" version="1">MCKAQNSQINSKAEFLPSCLSCIHYNNDTIVLLILKDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MH9</accession>
    <name>Q73MH9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972135.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679175.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1529"/>
    <dbReference type="EnsemblBacteria" id="AAS12046">
        <property type="protein sequence ID" value="AAS12046"/>
        <property type="gene ID" value="TDE_1529"/>
    </dbReference>
    <dbReference type="GeneID" id="2740891"/>
    <dbReference type="KEGG" id="tde:TDE_1529"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1466"/>
    <dbReference type="HOGENOM" id="CLU_390256_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="707" mass="83717" checksum="26DED7781278D6AA" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MJ6</accession>
    <name>Q73MJ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972118.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671216.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1512"/>
    <dbReference type="EnsemblBacteria" id="AAS12029">
        <property type="protein sequence ID" value="AAS12029"/>
        <property type="gene ID" value="TDE_1512"/>
    </dbReference>
    <dbReference type="GeneID" id="2739718"/>
    <dbReference type="KEGG" id="tde:TDE_1512"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1451"/>
    <dbReference type="eggNOG" id="COG4393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045824_0_0_12"/>
    <dbReference type="OMA" id="VPIEGWS"/>
    <dbReference type="OrthoDB" id="1663702at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018758">
        <property type="entry name" value="FtrD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10080">
        <property type="entry name" value="FtrD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="FtrD-like" evidence="2">
        <location>
            <begin position="321"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="422" mass="48017" checksum="525219A73FD85E8E" modified="2004-07-05" version="1">MFWRCTILKFYIRVIEAGIGFALVLAVVFASFRTQRPEKKRYIVFLGILTGFIGSIVSAILRSIPNYINRTNFAFWSMIPVSIFFLILIVLLLFKTKAKKSLLYENIFGTTVFLYTAATIFYYLPVIITLSTTLVNYGESAVSTLVLYRLIGYLLGIVFIVLASLSIYKTLIKLSDIELNITVIASLCILGITQIVVIIQRLYSLRIIPRNNFIFWFIAMVVNNGNFFIFAVIVFIMFAPILLWKKNIKITEAYNNNAELRKIKAKKRNAKRWARFSLSLLVISVFSLSFLRFYVDREVPLSPPENYTIADGMAVISLEQLEDDKLHRYEYITEQGIGMRFIAIKKSEGSYGVGLDACDICGPSGYFERNNEVICKLCDVVMNKATIGFPGGCNPVPIPYIVHDGNIKIKISDLESEAHRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MK8</accession>
    <name>Q73MK8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PGA_cap domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972106.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1500"/>
    <dbReference type="EnsemblBacteria" id="AAS12017">
        <property type="protein sequence ID" value="AAS12017"/>
        <property type="gene ID" value="TDE_1500"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1500"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1439"/>
    <dbReference type="eggNOG" id="COG2843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038823_0_2_12"/>
    <dbReference type="OMA" id="HFYFMNF"/>
    <dbReference type="OrthoDB" id="1003186at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="PGA_cap" evidence="3">
        <location>
            <begin position="69"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="435" mass="50688" checksum="A40B16FFE4BE3717" modified="2004-07-05" version="1">MNNYYNIFIYCILYNINCQCIIITIMKKNLNYYLFLFITAAVFVLNSCNSTEISESKLPQKENDISELVLSFSGDIMAHDVNFKMKDYNRIYDDVRDILLNDDLTFGNVETPVCEERPLSSFPCFNIHKDYLRAAIEGGFDVFSFANNHTNDQGIQGIDGTIKSFNALKEEYKNKELFSSGLKNKEDEDFKPVLIEKKGWKILFLSVTELINSHGKSKHRLYYSEPTKTGREKLLLSIKKMREENPCDIFILSLHLNEAEYGLKVLDSKKTWFKALAQAGIDVVWANHPHVLQDWELSDVEILTDDSKKDIIQINKGENNEPLDSFLTHKKNAFFMYSMGNFISGQRWKVNYADPAYYREYTGDSIIMQLRFKKIDGILQPEIEAAPVLITNYNEKDAPVIKRFTQEWIETLPEKERAYYLKRLELMRAYLPKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ML1</accession>
    <name>Q73ML1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972103.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678158.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1497"/>
    <dbReference type="EnsemblBacteria" id="AAS12014">
        <property type="protein sequence ID" value="AAS12014"/>
        <property type="gene ID" value="TDE_1497"/>
    </dbReference>
    <dbReference type="GeneID" id="2739898"/>
    <dbReference type="KEGG" id="tde:TDE_1497"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1436"/>
    <dbReference type="eggNOG" id="ENOG5031CYV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2002888_0_0_12"/>
    <dbReference type="OrthoDB" id="1821048at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="138" mass="16005" checksum="3A536EE6380BE191" modified="2004-07-05" version="1">MIDLKSKISGIFKNMQVSFSHHRKPVIIIVCALIFILTLSLLLIIFSQKKDDASYSETKKAVLSSKNSDFKSGKVDTDKLQIIDEPLYLPPIQFSREQHKIWEKEEVDYWYEPPAEKDMEELHKQNKKIADKILEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MM9</accession>
    <name>Q73MM9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DHH superfamily protein, subfamily 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972085.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679142.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1479"/>
    <dbReference type="DNASU" id="2741594"/>
    <dbReference type="EnsemblBacteria" id="AAS11996">
        <property type="protein sequence ID" value="AAS11996"/>
        <property type="gene ID" value="TDE_1479"/>
    </dbReference>
    <dbReference type="GeneID" id="2741594"/>
    <dbReference type="KEGG" id="tde:TDE_1479"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1418"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039720_0_0_12"/>
    <dbReference type="OMA" id="YTGIMTD"/>
    <dbReference type="OrthoDB" id="1040743at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="28"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="196"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="333" mass="37112" checksum="1CD462904BECD56C" modified="2004-07-05" version="1">MHNSSSSTIGKPLIPQKLPEFLNAYENFIIAGHKEPDGDCIGSCLAMSFFLKRKNKNCILMSAGPFKRTEIKEYEHLFTDKLKISDKINPKTTGLIILDCSNFDRVGEIAELISGFNYIIIDHHATNTEKSDTSLIMPEAPSTTYLIQSIIEEIGEKLTKEEADALFFGLCTDTGFFRHLDAGSAEVFAHASRLIEAGANPKQTFMKINGGKKFESRLLISRILNRMKTYYDGRLVVSYETYDDLLEFGLESRDSDILYQLIQSIEGVEAICIVRQDSPSHCSVGFRSLDKIDVSKIAASFGGGGHKQASGLYIEGKFDDLIPRFVEAFGTQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MQ2</accession>
    <name>Q73MQ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GGDEF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972062.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679113.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1456"/>
    <dbReference type="EnsemblBacteria" id="AAS11973">
        <property type="protein sequence ID" value="AAS11973"/>
        <property type="gene ID" value="TDE_1456"/>
    </dbReference>
    <dbReference type="GeneID" id="2741419"/>
    <dbReference type="KEGG" id="tde:TDE_1456"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1397"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574835_0_0_12"/>
    <dbReference type="OrthoDB" id="1715869at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="342"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="475" mass="53981" checksum="40EEFA279691DCCA" modified="2004-07-05" version="1">MKKMYIGIYAAIALLIIVGTFSWFIYGIIRDSDTGAEEAKSTFAYFAKQIIISSEKENFAQSEYNQRLYALADELEIKAFVISKPSKSIVISWPKDSDLISYDEGGNFVIKPASLFIKNHSGKINVKTMKSYDTELVLTASIPTLKPAAIYLRIRSAFFIILAVTILTVIIILSTNLTNTQDRVYADINKRTFEDDFKDDISLSPKTYVEENKYYEPEEVYPHDYTEAKKEDEAGLRPIENTKSGKDEDIYGLEDLDNLKITQQFPYEAGKETKLKEEKDISYISSDSEEYNDVKASDFGTVNAEAIEKVRGLYSPITGISWQEYLPEYLESELRRAASSEQDIALVIMKLEDFTLESMIGKKISALLIDFIKFRDMIFEFDNNGFAAILQDTNLDEAMKKAEEIYKGTKNILTEYDISKSVSIGITTRTSRLISAGRMIEEAQAAVNRAIKNNEDPIVAFRVNPDKYREFISDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MY4</accession>
    <name>Q73MY4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971978.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1372"/>
    <dbReference type="EnsemblBacteria" id="AAS11889">
        <property type="protein sequence ID" value="AAS11889"/>
        <property type="gene ID" value="TDE_1372"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1372"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1318"/>
    <dbReference type="eggNOG" id="ENOG5031CBG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444756_0_0_12"/>
    <dbReference type="OMA" id="VADEIFY"/>
    <dbReference type="OrthoDB" id="504395at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="554" mass="63313" checksum="03D5A30DD82D8231" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N09</accession>
    <name>Q73N09_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971953.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671470.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1347"/>
    <dbReference type="EnsemblBacteria" id="AAS11864">
        <property type="protein sequence ID" value="AAS11864"/>
        <property type="gene ID" value="TDE_1347"/>
    </dbReference>
    <dbReference type="GeneID" id="2739448"/>
    <dbReference type="KEGG" id="tde:TDE_1347"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1295"/>
    <dbReference type="eggNOG" id="COG1579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073076_2_1_12"/>
    <dbReference type="OMA" id="EHCGRIL"/>
    <dbReference type="OrthoDB" id="833439at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="275" mass="31877" checksum="411DFD78C5BF9259" modified="2004-07-05" version="1">MDNDVLEKLRALQDILARKNELETEILDAPKALTQQEELLEKLKSGYIQMNSEYEELRKGIAVFKADLFEAEQKREKAEKAMDNIETQREYEILQKEIDDSTTKAETIRKDLLRLESQFKILDANIKQEEDLIAQTEKELEEHKQLLDSEISEKQNKVEELKLEEKKLSPGLSDETMFKFDRIIKNKHGVGIVSVQGNVCMGCHMILPAQFVNEVRSDQDIKFCPYCSRILFYEESELTAEQEAYFNDSDMEGLLDIGDSANEDFLASFEDKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N52</accession>
    <name>Q73N52_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971910.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1304"/>
    <dbReference type="EnsemblBacteria" id="AAS11821">
        <property type="protein sequence ID" value="AAS11821"/>
        <property type="gene ID" value="TDE_1304"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1304"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1253"/>
    <dbReference type="HOGENOM" id="CLU_3123848_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="50" mass="5747" checksum="89C00FBFC43A4C64" modified="2004-07-05" version="1">MDMEYTVVMPKKLDKIIRLMPEKAQDVLHNLILDIKKSGPVQPKIITTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N68</accession>
    <name>Q73N68_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ordered locus">TDE_1287</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971894.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678792.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1287"/>
    <dbReference type="EnsemblBacteria" id="AAS11805">
        <property type="protein sequence ID" value="AAS11805"/>
        <property type="gene ID" value="TDE_1287"/>
    </dbReference>
    <dbReference type="GeneID" id="2741041"/>
    <dbReference type="KEGG" id="tde:TDE_1287"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1237"/>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_1_3_12"/>
    <dbReference type="OMA" id="SHVVHIN"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:damaged DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="630"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="809"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1155" mass="132086" checksum="BD7767E9E61D84E5" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N69</accession>
    <name>Q73N69_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971893.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668595.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1286"/>
    <dbReference type="EnsemblBacteria" id="AAS11804">
        <property type="protein sequence ID" value="AAS11804"/>
        <property type="gene ID" value="TDE_1286"/>
    </dbReference>
    <dbReference type="GeneID" id="2741040"/>
    <dbReference type="KEGG" id="tde:TDE_1286"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1236"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094983_0_0_12"/>
    <dbReference type="OMA" id="WWYRLGS"/>
    <dbReference type="OrthoDB" id="1438690at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="226" mass="25923" checksum="A1A100B1CCE7A37C" modified="2004-07-05" version="1">MITGKRFKFILLTFIFAAGLFFTQAGILFAQDKPDALKLYRQGRSLDSIGRREDARAAYLSAIEICRNELKVNSKNMDSYAVYTWCLFRLGRYKDTELVCSDALKIGRDARIIETLAEAQFFLGNYKDSLRNMEMYIEMAPNGERISVAHFFVGEIYRNTKKYHKADIAYSISVHLEPSNSLWWYRLGIVREAAGEKEGAIAAYQTAVKLRPEFKEAAEALKRVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N74</accession>
    <name>Q73N74_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971888.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678786.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1281"/>
    <dbReference type="EnsemblBacteria" id="AAS11799">
        <property type="protein sequence ID" value="AAS11799"/>
        <property type="gene ID" value="TDE_1281"/>
    </dbReference>
    <dbReference type="GeneID" id="2740574"/>
    <dbReference type="KEGG" id="tde:TDE_1281"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1231"/>
    <dbReference type="eggNOG" id="COG3514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140900_2_0_12"/>
    <dbReference type="OMA" id="YGKGYQS"/>
    <dbReference type="OrthoDB" id="1855549at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025528">
        <property type="entry name" value="BrnA_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14384">
        <property type="entry name" value="BrnA_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="90" mass="10413" checksum="6D5C9D9A0D4835FD" modified="2004-07-05" version="1">MNITEAKKNLAKEKIEELKALNDRPIDTSDIPELTKADFLEMYRPIKKPLSIRLDSDIIAWLKSYGKGYQSRINTILRQAMDTDKKANVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N81</accession>
    <name>Q73N81_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide/dipeptide ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971881.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678776.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1274"/>
    <dbReference type="EnsemblBacteria" id="AAS11792">
        <property type="protein sequence ID" value="AAS11792"/>
        <property type="gene ID" value="TDE_1274"/>
    </dbReference>
    <dbReference type="GeneID" id="2740567"/>
    <dbReference type="KEGG" id="tde:TDE_1274"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1225"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_0_12"/>
    <dbReference type="OMA" id="RAWWVVS"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="305" mass="33932" checksum="CC4833F349AD1A44" modified="2004-07-05" version="1">MENNMTEDKTYFSENVSEEKKNTYFNEVVEKLLNNKLAMAGLIFFLLLSLLVIILPFILNLDPYTSDPAAFNSAPTRSHILGTDAIGRDLFARLIYGGRTSLMVGVVSTFISLSIGVPLGLIAGYYKKIWEVFIMRLGDIFLSFPSIILILVLVSVIGPSIWSVTIVLGVLQWTVFARLIYANVLSIKEKEYIEAAKSIGTSNFSIILKYILPNAFPPILITVTFNVARAILSESALSFLGMGVQPPKASWGNMLYDAQSITVLSRYYWVWLPPGLCIVLTVLSINFFGDGIRDALDPRLKIQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N84</accession>
    <name>Q73N84_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971878.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677802.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1271"/>
    <dbReference type="EnsemblBacteria" id="AAS11789">
        <property type="protein sequence ID" value="AAS11789"/>
        <property type="gene ID" value="TDE_1271"/>
    </dbReference>
    <dbReference type="GeneID" id="2740564"/>
    <dbReference type="KEGG" id="tde:TDE_1271"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1222"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_12"/>
    <dbReference type="OMA" id="EPLRTYY"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="323" mass="36623" checksum="8E646962E02E319C" modified="2004-07-05" version="1">MSSEYLLETINLSKHFSESKSLFNWNPKSVKAVNNVNIKVKPKEVLGLVGESGCGKSTLGRTILRLLPATSGKILYKGDDILKYNNKQMFELRKKMQIIFQDVYSSLNPRMTVGDIVTAPLNVFKEGDKKYRQNKVIEMLEEVGLRAQYLNRFPHEFSGGQRQRIVIARSLIMNPELVICDEPVSALDVSVRAQVLNLMKKLKEEKGLTYIFISHDLSVVNHISDRIAVMYLGNVIELAERDELFKNAFHPYTKALLSAVPIASTEARKNRIILKGDIPNPYDPPKGCCFNTRCPKATQRCREEIPELKTLASDHLCACFYPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NB6</accession>
    <name>Q73NB6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971846.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1239"/>
    <dbReference type="EnsemblBacteria" id="AAS11757">
        <property type="protein sequence ID" value="AAS11757"/>
        <property type="gene ID" value="TDE_1239"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1239"/>
    <dbReference type="HOGENOM" id="CLU_3158999_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="48" mass="5874" checksum="F454BC159CE3C50D" modified="2004-07-05" version="1">MEKSSSVKAFRPYLILFLSILGINYIKLGIKYINSHKKKRYRIYRYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NC4</accession>
    <name>Q73NC4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971838.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1231"/>
    <dbReference type="EnsemblBacteria" id="AAS11749">
        <property type="protein sequence ID" value="AAS11749"/>
        <property type="gene ID" value="TDE_1231"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1231"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1186"/>
    <dbReference type="eggNOG" id="ENOG5033K7C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_480541_0_0_12"/>
    <dbReference type="OMA" id="RHGNASE"/>
    <dbReference type="OrthoDB" id="842799at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038636">
        <property type="entry name" value="Wzi_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284608" evidence="1">
        <location>
            <begin position="22"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="574" mass="64732" checksum="A738FC6A15189E61" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NF0</accession>
    <name>Q73NF0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">ftsA</name>
        <name evidence="8" type="ordered locus">TDE_1203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Self-interacts. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="5">Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971810.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678694.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1203"/>
    <dbReference type="EnsemblBacteria" id="AAS11721">
        <property type="protein sequence ID" value="AAS11721"/>
        <property type="gene ID" value="TDE_1203"/>
    </dbReference>
    <dbReference type="GeneID" id="2741164"/>
    <dbReference type="KEGG" id="tde:TDE_1203"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1158"/>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037850_3_2_12"/>
    <dbReference type="OMA" id="DGIIRHT"/>
    <dbReference type="OrthoDB" id="1044637at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02033">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="7">
        <location>
            <begin position="6"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="414" mass="44362" checksum="E1A564B1C9031CD6" modified="2004-07-05" version="1">MSDDIIVGLDIGSKNIRVVVAEKNDEGHLQITGIGMSESTGIHRGIVTNIENTVQGINKAVDEAEVMSGVDISHCTVGLGGVHIEGVNSKGVFPIRDKGKNNKEIDRSDIDAVINSAQAVEFTGDREIIHVVPQSYTVDRQRGIKDPLNMIGTRLEAEVHLITGVATSMKNIPNCVQRADLNIDGLMHNGLADVRAVMTNDEQELGSILIDIGAGTTDIVVMQNGGPIITAALPVGGIQVTNDLAIVKSIPFDTAEKIKISSGCCWMPFVERDEQVLIPAFGGRGPEEIYRSEICEILQARMAEIFVMVKNKVDDLTQGSRLGGSVIICGGGALLNGTTELADEIFGMQSARLGIPSTIGGVVGRYRSPEFATVLGLILHRLDDQNKIGKVSSSRKENSGLVVSKIKNFIKELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NI1</accession>
    <name>Q73NI1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971779.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956917.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1171"/>
    <dbReference type="EnsemblBacteria" id="AAS11660">
        <property type="protein sequence ID" value="AAS11660"/>
        <property type="gene ID" value="TDE_1171"/>
    </dbReference>
    <dbReference type="GeneID" id="2740068"/>
    <dbReference type="KEGG" id="tde:TDE_1171"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1129"/>
    <dbReference type="eggNOG" id="COG0790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_36_2_12"/>
    <dbReference type="OMA" id="YAEAMKW"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284611" evidence="1">
        <location>
            <begin position="20"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="267" mass="30489" checksum="99A9AEC2F08E0913" modified="2004-07-05" version="1">MKKIFFCLILFMIALLCFADKKFEKVKAAAEQGDAFAQFNLAAMYDKGDESLVDKKQAVYWYTKAAEQGYDVAQLFLAFMYDIGDGIPIDKKQAFYWYTKAAEQGNVAAQCILGLMYSNGDGTPVDKKQAFYWFKKAAEQGYAKAQFNLGGMYYKGNGILTDKKQAFYWFKKAAEQGYAEAQFNLALMYYNGDGILADKKQAFYWYTKSAEKGLAFAQFNLGLMYSNGDGILADKKQAAYWIKQAYENGYEPAKELWDADELWKYQD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NP6</accession>
    <name>IF2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infB</name>
        <name type="ordered locus">TDE_1106</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971714.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682412.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NP6"/>
    <dbReference type="SMR" id="Q73NP6"/>
    <dbReference type="STRING" id="243275.TDE_1106"/>
    <dbReference type="PRIDE" id="Q73NP6"/>
    <dbReference type="EnsemblBacteria" id="AAS11595">
        <property type="protein sequence ID" value="AAS11595"/>
        <property type="gene ID" value="TDE_1106"/>
    </dbReference>
    <dbReference type="GeneID" id="2740236"/>
    <dbReference type="KEGG" id="tde:TDE_1106"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1065"/>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006301_5_1_12"/>
    <dbReference type="OMA" id="NRDNRTG"/>
    <dbReference type="OrthoDB" id="115308at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000228257" description="Translation initiation factor IF-2">
        <location>
            <begin position="1"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="375"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="384"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="409"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="430"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="484"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="520"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="384"/>
            <end position="391"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="430"/>
            <end position="434"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="484"/>
            <end position="487"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="896" mass="98141" checksum="1A6C6B19A82A6283" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NQ5</accession>
    <name>Q73NQ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971705.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682407.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1097"/>
    <dbReference type="EnsemblBacteria" id="AAS11586">
        <property type="protein sequence ID" value="AAS11586"/>
        <property type="gene ID" value="TDE_1097"/>
    </dbReference>
    <dbReference type="GeneID" id="2740227"/>
    <dbReference type="KEGG" id="tde:TDE_1097"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1056"/>
    <dbReference type="eggNOG" id="COG0456">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085384_0_0_12"/>
    <dbReference type="OrthoDB" id="1840555at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="284" mass="33096" checksum="3DC70CCAD073F11A" modified="2004-07-05" version="1">MSIKSIGLTDKIISQKEVKDFLQKANLNQRGNLIGLFDKEKIIGAGSLYTNSFHPYRDYINIHIEKDYRNKGLGSRLLKALKENSAKKRFQVMCSSGKEELIQFLLKEGFVLARRSYSFDLKKEAQNIFLSKETSTEFKNMQIKPFINLNSKEKEEFKKIFYFNYADTHKSINPLNKDICIKEFSNEILADCDEERSSCLISNNEVSAYVIVYIENLPEIGYLGGKTIEEIETYLNYFQVIINNLLNAYEQIYFEIDDTDYYAFPLMTALQINCKESYNTYILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NS5</accession>
    <name>Q73NS5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971685.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002689609.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1077"/>
    <dbReference type="EnsemblBacteria" id="AAS11566">
        <property type="protein sequence ID" value="AAS11566"/>
        <property type="gene ID" value="TDE_1077"/>
    </dbReference>
    <dbReference type="GeneID" id="2739089"/>
    <dbReference type="KEGG" id="tde:TDE_1077"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1037"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        </location>
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        </location>
    </feature>
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        </location>
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            <end position="332"/>
        </location>
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            <end position="392"/>
        </location>
    </feature>
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        <location>
            <begin position="165"/>
            <end position="401"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS11566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="401" mass="44295" checksum="4D7C929A08CB6DEF" modified="2004-07-05" version="1">MSKFKTHEKWFIFLKAANIFFTVLNSCVISLYLKSQNFSYFQISILFSLILGVGFIFEYPSGLLADCFGRKKTFAAGLFFSCMQYLCYGFARNFLFFLFGAFFAGISDAFLSGSLEGWLVSENKKIQNEKNNVRVFSISRTCINIFSVVSILLIARFIDLGINRLFIFAGIGLFILSGAAFFIFPDNKAQNTTIKQNLASSVKELFHNQSVLQAGLILASLYTCFSIYILIWQNMAHSLSFTNMHIPLLRSITLIGGGVASYTARKARTVSAKRKIFTICFILIAVSFCIMAVSSSSLIFFKTYLFLQPFTAAMFIYGLGTGAVIPLFYGYLSEVIKGEAHASVFSLVSGFASLVGIGTTIGIGIVIDYVGFSKILIVGAVFSGFIGVIIAVKFGKIKLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NU4</accession>
    <name>Q73NU4_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1058"/>
    <dbReference type="EnsemblBacteria" id="AAS11547">
        <property type="protein sequence ID" value="AAS11547"/>
        <property type="gene ID" value="TDE_1058"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1058"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1020"/>
    <dbReference type="HOGENOM" id="CLU_195397_1_0_12"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="44" mass="5144" checksum="232F2C8669EAEB44" modified="2004-07-05" version="1">MSTFEMDIKDRVKRETAKLMKNRGYPISEILLMTGLPESEIEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NV0</accession>
    <name>Q73NV0_TREDE</name>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_1052</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
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            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="6 7">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the rubredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971660.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670545.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1052"/>
    <dbReference type="EnsemblBacteria" id="AAS11541">
        <property type="protein sequence ID" value="AAS11541"/>
        <property type="gene ID" value="TDE_1052"/>
    </dbReference>
    <dbReference type="GeneID" id="2741326"/>
    <dbReference type="KEGG" id="tde:TDE_1052"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1012"/>
    <dbReference type="eggNOG" id="COG1773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128747_3_3_12"/>
    <dbReference type="OMA" id="APKDMFE"/>
    <dbReference type="OrthoDB" id="2047418at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024922">
        <property type="entry name" value="Rubredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000071">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="52" mass="5544" checksum="DC1D1D07223522AE" modified="2004-07-05" version="1">MDKYVCDLCGYVYDPALGDPDGGIAPGTAFEDIPDDWVCPLCGVGKESFTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NV8</accession>
    <name>Q73NV8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971652.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682352.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1044"/>
    <dbReference type="EnsemblBacteria" id="AAS11533">
        <property type="protein sequence ID" value="AAS11533"/>
        <property type="gene ID" value="TDE_1044"/>
    </dbReference>
    <dbReference type="GeneID" id="2741318"/>
    <dbReference type="KEGG" id="tde:TDE_1044"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1004"/>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028799_3_2_12"/>
    <dbReference type="OMA" id="WFTSKLA"/>
    <dbReference type="OrthoDB" id="1558251at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="357" mass="40866" checksum="EDCD7BDA7DF012D2" modified="2004-07-05" version="1">MKLLQRYLLKLFIPTFVVAMLFFILLLQLGDLFANIVAYLQNGAQFKDIVKVMWLYIPKCIAYSVPLAILFAGSYTMGNLYAQNELTSIFSAGISLGRFTLPLLVLGFFFSVGMIFFEDNVVIKYFYEKTQLSKKLLQEEESLDTQDLVILSELGKIVYTADYFNAENQTLANAYIIVRDEDGNLSLVIKSSHMVWNEDRWTTDSAEVYRFDEKNSVSCLNNIPDNIILSEPPANFQKNLSSVDEMRISEAKEFIAALKKNGLPYYEALSKYHRRFSFPFTIFIVLFFSISLGGKFKKNILLMSILFSLGIATLFYVTEMVTMLSAKWEYISPLAGAWTPIFIFSILSIFLLKKSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NW7</accession>
    <name>Q73NW7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971643.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670505.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1035"/>
    <dbReference type="EnsemblBacteria" id="AAS11524">
        <property type="protein sequence ID" value="AAS11524"/>
        <property type="gene ID" value="TDE_1035"/>
    </dbReference>
    <dbReference type="GeneID" id="2741513"/>
    <dbReference type="KEGG" id="tde:TDE_1035"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.995"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_3_12"/>
    <dbReference type="OMA" id="KDLIRGH"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="108" mass="12423" checksum="D152E63DAE16F3B9" modified="2004-07-05" version="1">MLNKQEILRGLTDTLILGRLYSKDSYGYEINKQIHQKSSSLFQLTEATLYTAFRRLEAAGLLTSYWGDGDTGARRRYYSITKTGKKLYRENVNDWEEFSAAISGLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NX9</accession>
    <accession>Q73RE9</accession>
    <name>Q73NX9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ISTde2, transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0140</name>
        <name evidence="3" type="ordered locus">TDE_1022</name>
        <name evidence="4" type="ordered locus">TDE_1752</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405</strain>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970757.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971630.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972356.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956682.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0140"/>
    <dbReference type="EnsemblBacteria" id="AAS10638">
        <property type="protein sequence ID" value="AAS10638"/>
        <property type="gene ID" value="TDE_0140"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11511">
        <property type="protein sequence ID" value="AAS11511"/>
        <property type="gene ID" value="TDE_1022"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12267">
        <property type="protein sequence ID" value="AAS12267"/>
        <property type="gene ID" value="TDE_1752"/>
    </dbReference>
    <dbReference type="GeneID" id="2741501"/>
    <dbReference type="KEGG" id="tde:TDE_0140"/>
    <dbReference type="KEGG" id="tde:TDE_1022"/>
    <dbReference type="KEGG" id="tde:TDE_1752"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.140"/>
    <dbReference type="eggNOG" id="COG2826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035706_0_2_12"/>
    <dbReference type="OMA" id="RSVIWRE"/>
    <dbReference type="OrthoDB" id="1780129at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="199"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="358" mass="42243" checksum="08607B49AE22B66F" modified="2004-07-05" version="1">MNQKNDTIKSKKWKHLSEKERYAIEALFKSDYNARQIAQSLNRDRRTIQREIKRGMVIKVTENPYVSRNPKVPDYLEKTVYSARKGQQRADKMKLLKGRGLKIGKDKKLLHYLETCIADNKFSPDAAIGQIKELGLQFPVMICTKTVYNMIDRGDFSRLTNKDLPVKRNKTKRKYKKISKIAKNNIKGRSIEQRSEQINKRQEKGHWEMDLVIGKGRCCLQVMTERVTRKELIFKIPDKKQESIKKNIDMLEMKYKDEFKEIFKSITMDNGTEFLDQEGLETSCLKEGEKRTTCYYAHPYSSWERGSNENANKLIRRFIPKGADISKYSDIQIKQVENWINNYPRRMFGYKTANQMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P41</accession>
    <name>Q73P41_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0958</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971568.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682267.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0958"/>
    <dbReference type="EnsemblBacteria" id="AAS11449">
        <property type="protein sequence ID" value="AAS11449"/>
        <property type="gene ID" value="TDE_0958"/>
    </dbReference>
    <dbReference type="GeneID" id="2740766"/>
    <dbReference type="KEGG" id="tde:TDE_0958"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.922"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047251_0_0_12"/>
    <dbReference type="OMA" id="TNIMFAE"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="5"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="37"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="303" mass="33781" checksum="8CA7D82198CBC873" modified="2004-07-05" version="1">MKWALVLSGGGAKGLAYIGMFKALEELEYPLPDCIVGCSMGAIIGGLYASGMTVDEMISFFSKNFELTDYLDVSHFGFGLTKLTRFLQIGASLNNLISHQGADSGERSLTLFKKLSCYQTFDQLKIPFYCNATDLCEGNEVVFDKGFLADAMRASYSYPGFFAPFNYNGKLFVDGCVKNNTPVWIAKEKGFKNILAVTLGTFKTINNDDLDSSISVLTRCLEVAAIRSDYSVCNTPTHILDIDTDTVSHDFSDPLSQIQMGYSITMNNKKELLEFFQKGLSGFLNRRRMTKKTAKRLKYEKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P47</accession>
    <name>Q73P47_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971562.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682257.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0952"/>
    <dbReference type="EnsemblBacteria" id="AAS11443">
        <property type="protein sequence ID" value="AAS11443"/>
        <property type="gene ID" value="TDE_0952"/>
    </dbReference>
    <dbReference type="GeneID" id="2740760"/>
    <dbReference type="KEGG" id="tde:TDE_0952"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.916"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_12"/>
    <dbReference type="OMA" id="WARDICA"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="514" mass="57383" checksum="1A83569BD9DCA342" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P50</accession>
    <name>ENO_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enolase</fullName>
            <ecNumber evidence="1">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eno</name>
        <name type="ordered locus">TDE_0949</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <text evidence="1">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971559.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682247.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73P50"/>
    <dbReference type="SMR" id="Q73P50"/>
    <dbReference type="STRING" id="243275.TDE_0949"/>
    <dbReference type="PRIDE" id="Q73P50"/>
    <dbReference type="EnsemblBacteria" id="AAS11440">
        <property type="protein sequence ID" value="AAS11440"/>
        <property type="gene ID" value="TDE_0949"/>
    </dbReference>
    <dbReference type="GeneID" id="2740982"/>
    <dbReference type="KEGG" id="tde:TDE_0949"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.913"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_12"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="OrthoDB" id="533698at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="chain" id="PRO_0000133998" description="Enolase">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="1">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="368"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <sequence length="433" mass="47386" checksum="5BB9F135EA0A503D" modified="2004-07-05" version="1">MSDIIYIEGREILDSRGNPTVEVEVQLSDFSYGRACVPSGASTGEYEALEMRDGDKSRYMGKGVLKAVDQVNTVIAEELDGADALDQAEIDNMLINLDGTENKSKLGANAMLGVSMAVARAAADSLGLPLYRYLGGVHAMQMPVPMANIINGGRHSDNKIDFQEYMIMPVGAPSIREGIRMTAEVFHALKDILKKEGHVTAVGDEGGFAPNIENVQALDYIMKAIEKAGYKPGKDVVIALDCASSELFDAGDRKGYKFWKSEPSKILNADEMVDLFKDWISKYPIVSIEDPLDQNDWEGYAKMTKELGNQIQIVGDDFFVTNTKRLARGIEEGACNSILIKLNQIGTVTETIDAVRMAQKAGYTAVISHRSGETEDAFIADLAVALETGQIKTGSMSRSDRIAKYNQLMRIEDELGYNARYAGMATFANLIKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P71</accession>
    <name>PHNC_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphonates import ATP-binding protein PhnC</fullName>
            <ecNumber evidence="1">7.3.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">phnC</name>
        <name type="ordered locus">TDE_0928</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + phosphonate(out) = ADP + H(+) + phosphate + phosphonate(in)</text>
            <dbReference type="Rhea" id="RHEA:18065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16215"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.3.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (PhnC), two transmembrane proteins (PhnE) and a solute-binding protein (PhnD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.</text>
    </comment>
    <dbReference type="EC" id="7.3.2.2" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971538.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682233.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73P71"/>
    <dbReference type="SMR" id="Q73P71"/>
    <dbReference type="STRING" id="243275.TDE_0928"/>
    <dbReference type="EnsemblBacteria" id="AAS11419">
        <property type="protein sequence ID" value="AAS11419"/>
        <property type="gene ID" value="TDE_0928"/>
    </dbReference>
    <dbReference type="GeneID" id="2740393"/>
    <dbReference type="KEGG" id="tde:TDE_0928"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.896"/>
    <dbReference type="eggNOG" id="COG3638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="ALINCPK"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015416">
        <property type="term" value="F:ABC-type phosphonate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03256">
        <property type="entry name" value="ABC_PhnC_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012693">
        <property type="entry name" value="ABC_transpr_PhnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02315">
        <property type="entry name" value="ABC_phnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51249">
        <property type="entry name" value="PHNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0918">Phosphonate transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092737" description="Phosphonates import ATP-binding protein PhnC">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="3"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01713"/>
        </source>
    </evidence>
    <sequence length="256" mass="28468" checksum="2967D0D0AF9473DC" modified="2004-07-05" version="1">MILELKNISKTYPSGRRALQSISFKIEEGEILAIIGLSGAGKSTMLRCINRLVEPDEGEVIFLGEKINKLKGKKLRQYRSKIGMIFQNYNLVERLNAVENVLHGCLGSIPSYRGALGLYTEEEKEKAFALLQTVGMEEFAFQRCSELSGGQKQRIGIARALMQSPKLLLCDEPIASLDPQSSETVLNYIKEFAVNKNIACLISLHQMEAAKKYADRIIALNNGKIVFDGIPDSLNDEVLHKEIFTNVSIDSGEKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PA5</accession>
    <name>Q73PA5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971504.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682174.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0894"/>
    <dbReference type="EnsemblBacteria" id="AAS11385">
        <property type="protein sequence ID" value="AAS11385"/>
        <property type="gene ID" value="TDE_0894"/>
    </dbReference>
    <dbReference type="GeneID" id="2739768"/>
    <dbReference type="KEGG" id="tde:TDE_0894"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.864"/>
    <dbReference type="eggNOG" id="COG4587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084465_1_2_12"/>
    <dbReference type="OMA" id="VIEYNIL"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="263" mass="30276" checksum="982B3AD765E7416C" modified="2004-07-05" version="1">MNAYYKVFKISLANQLEYRVNFISGFLFSLFPFTVNVLLWIAVSYQSKDMPFKADGIVSYYFLTLITYNITSTVSVFKISDDIRLGTLNQYLIKPYNYALYQLASDLPHRFIFIVMNAVSITVLYFLLQRYFVFTLSLWKALFFVLFLIAGYLINFFIDFLIALYSFYFSRVSSLYTSIRVLKNISAGIIFPLVLLPESVFSLLKNLPFAFISHIPVSLLLDDVPLCTAFISLCKSLGWITLLAIFCAVVWKRGMKIYSAYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PG2</accession>
    <name>Q73PG2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ion-translocating oxidoreductase complex subunit D</fullName>
            <ecNumber evidence="10">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Rnf electron transport complex subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nqrB</name>
        <name evidence="10" type="synonym">rnfD</name>
        <name evidence="11" type="ordered locus">TDE_0837</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NqrB/RnfD family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="10"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971447.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002685644.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0837"/>
    <dbReference type="EnsemblBacteria" id="AAS11328">
        <property type="protein sequence ID" value="AAS11328"/>
        <property type="gene ID" value="TDE_0837"/>
    </dbReference>
    <dbReference type="GeneID" id="2739614"/>
    <dbReference type="KEGG" id="tde:TDE_0837"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.806"/>
    <dbReference type="eggNOG" id="COG4658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042020_1_0_12"/>
    <dbReference type="OMA" id="GWQWINL"/>
    <dbReference type="OrthoDB" id="1654433at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00462">
        <property type="entry name" value="RsxD_RnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011303">
        <property type="entry name" value="RnfD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578">
        <property type="entry name" value="PTHR30578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01946">
        <property type="entry name" value="rnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="10">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="338" mass="36172" checksum="B088FE9C983156FC" modified="2004-07-05" version="1">MAESDKNEIFMSPAPHVVTPVKTQTLMLDVIIALLPLTAYGIYLFSIPALVRIIVSVLCCVGFESLFRKICRLDIRVKDLSAVITGLLLALVIPPNLPIWMLILGCFFAIVVAKEFFGGLGANVFNPALVGRAFMFASFSGAMTSWIQPGNSIFDAVSTATPLKLINAKEGIALSASEIAKTLNLSSSTDLYTQLILGNHAGCIGETSILLILLGFAYLLFKKVIDWKTPVTMMLTAVVITSIAGINPILTLTSGGLAFGAVFMATDYVTSPVTPKGKLLFGAGCGLITGLIRLFSGMPEGVMYSILIMNAVVPFLNKIIPVKYGYVKPPKKNKEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PG7</accession>
    <name>Q73PG7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971442.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677204.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11323">
        <property type="protein sequence ID" value="AAS11323"/>
        <property type="gene ID" value="TDE_0832"/>
    </dbReference>
    <dbReference type="GeneID" id="2739516"/>
    <dbReference type="KEGG" id="tde:TDE_0832"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.801"/>
    <dbReference type="eggNOG" id="ENOG5031C8C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127157_0_0_12"/>
    <dbReference type="OMA" id="DWYVEPR"/>
    <dbReference type="OrthoDB" id="1319581at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="148" mass="16688" checksum="044A66900FE91ABE" modified="2004-07-05" version="1">MQKDRLHWSLGLLLEGNMNVPKDCALGTGLYGMVVLPDWVKVGRFSAGAKLLYSTGFKRYSLLDTALLFRWNFYDFEKLKKVDSGFFFQAEGGLSLGWNRKASKPFVFGLGEAAFGYRFTVKNFFIEPYIRGGYPVIWAAGISGGFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PI5</accession>
    <name>Q73PI5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971424.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682075.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0814"/>
    <dbReference type="EnsemblBacteria" id="AAS11305">
        <property type="protein sequence ID" value="AAS11305"/>
        <property type="gene ID" value="TDE_0814"/>
    </dbReference>
    <dbReference type="GeneID" id="2739556"/>
    <dbReference type="KEGG" id="tde:TDE_0814"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.786"/>
    <dbReference type="HOGENOM" id="CLU_3012957_0_0_12"/>
    <dbReference type="OrthoDB" id="2057904at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="56" mass="6484" checksum="7E61E2AA6FA6C524" modified="2004-07-05" version="1">MKTVEAIKNCEPVSAIQKILMEKEIPPRVEYSLSEMGKSFMKVLKVMQKWGEENLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PP2</accession>
    <name>Q73PP2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+/H+ antiporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_0755</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971366.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669985.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0755"/>
    <dbReference type="EnsemblBacteria" id="AAS11247">
        <property type="protein sequence ID" value="AAS11247"/>
        <property type="gene ID" value="TDE_0755"/>
    </dbReference>
    <dbReference type="GeneID" id="2739874"/>
    <dbReference type="KEGG" id="tde:TDE_0755"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.730"/>
    <dbReference type="eggNOG" id="COG1757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_551812_0_0_12"/>
    <dbReference type="OMA" id="FAACAPI"/>
    <dbReference type="OrthoDB" id="580055at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018461">
        <property type="entry name" value="Na/H_Antiport_NhaC-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03553">
        <property type="entry name" value="Na_H_antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_antiporter" evidence="7">
        <location>
            <begin position="15"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="491" mass="53095" checksum="05A3A02B2BF8E86F" modified="2004-07-05" version="1">MRAFFKLSPVLLLAGLMMISNIESFSNALGFKLDILIIAPIAVIYASIVAMITEKFKFNDILNSAVDNVKEMQLVFFILMFAYAMADAFMSTGVGASIITLSLNIGISARTVALVAFLVSSVLSVATGTSWGTFAACAPIFLWMTHILNGNLVLSIAAIAGGSCFGDNLGLISDTTVVSSGIHRVEVTHRMKNQGLWSLVCLIIAGGLFLIAGLSLPGDAVSPQKAIEAIPQEVWTKLAEEKPVAVDLLNQVQHGVPVYMVIPLILVIGIALKGYSTLLCLGAGIVSCFILGRFAGTVSGLLAFFDIVYNGFVGAGSWVIIMMMWVAAFGGIMSKMDAFRPLSNLAVKLSRNVRQLMFWNGIISLLGNAALADEMAQIVTVGPIIRDITEENVEGDEKDLYSLKLRNATFSSALGIFGSQLIPWHVYLSFFIGIAGTVYPLYQFSQTQIIKYNFMAHISVITILLFTLFGIDRIFPKFGIASEPKVRLKKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PQ2</accession>
    <name>GRDA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>Glycine/sarcosine/betaine reductase complex component A</fullName>
            <ecNumber>1.21.4.2</ecNumber>
            <ecNumber>1.21.4.3</ecNumber>
            <ecNumber>1.21.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Selenoprotein PA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Thioredoxin reductase complex selenoprotein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">grdA</name>
        <name type="ordered locus">TDE_0745</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) = [thioredoxin]-dithiol + glycine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="EC" id="1.21.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine = [thioredoxin]-dithiol + H(+) + phosphate + sarcosine</text>
            <dbReference type="Rhea" id="RHEA:12825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57433"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="EC" id="1.21.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[thioredoxin]-disulfide + acetyl phosphate + H2O + trimethylamine = [thioredoxin]-dithiol + glycine betaine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11848"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17750"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.21.4.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Component of the glycine, sarcosine and betaine reductase complexes, together with components B and C.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GrdA family.</text>
    </comment>
    <dbReference type="EC" id="1.21.4.2"/>
    <dbReference type="EC" id="1.21.4.3"/>
    <dbReference type="EC" id="1.21.4.4"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971356.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956809.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0745"/>
    <dbReference type="GeneID" id="2740299"/>
    <dbReference type="KEGG" id="tde:TDE_0745"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.720"/>
    <dbReference type="eggNOG" id="ENOG50313TT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142275_0_0_12"/>
    <dbReference type="OMA" id="IAMMEMV"/>
    <dbReference type="OrthoDB" id="1960942at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030700">
        <property type="term" value="C:glycine reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033795">
        <property type="term" value="F:betaine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030699">
        <property type="term" value="F:glycine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033794">
        <property type="term" value="F:sarcosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00826">
        <property type="entry name" value="GRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006812">
        <property type="entry name" value="GRDA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04723">
        <property type="entry name" value="GRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000181">
        <property type="entry name" value="Grc_selenoprot_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0712">Selenocysteine</keyword>
    <feature type="chain" id="PRO_0000249764" description="Glycine/sarcosine/betaine reductase complex component A">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="157" mass="16711" checksum="832BF2DDF8053BD1" modified="2008-02-26" version="2">MVDLKTKKVIIIGDRDGVPGEAIKLCAESAGAEVVYAATECFVUTSAGAMDLENQKRVKDLAEKYGPENVIVLLGGAEAESSGLACETVTVGDPTFAGPLAGVSLGLLCYHVAEPEIKSQIDPAVYEEQVSMMEMVMDVNAIIAEISEYRNKGCKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PR5</accession>
    <name>Q73PR5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971343.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681973.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0731"/>
    <dbReference type="EnsemblBacteria" id="AAS11224">
        <property type="protein sequence ID" value="AAS11224"/>
        <property type="gene ID" value="TDE_0731"/>
    </dbReference>
    <dbReference type="GeneID" id="2740095"/>
    <dbReference type="KEGG" id="tde:TDE_0731"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.707"/>
    <dbReference type="eggNOG" id="ENOG5033WHF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1229447_0_0_12"/>
    <dbReference type="OMA" id="FKFESPR"/>
    <dbReference type="OrthoDB" id="1451431at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004286031" evidence="2">
        <location>
            <begin position="20"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="218" mass="24485" checksum="8585D37BDECE1C00" modified="2004-07-05" version="1">MKKAIKIMFLAGFAVIALAGCANKLKPLGTVSSKIKKPEMLDHKNFKWDKPVPGWVAEEPNVIEKTSDYKGKDVYLFKFESPRSKSLEGAELWTRDFSVPSEMARMVKVRVESKAAAAAAGDKDKIEGYLEDIVKTITSTKLSGFKKETDYWVQMRYFDADGNPDGDDYTYLVLYSISKKTLDKLIQNAINGADEDKPKSEEEKAVRQRVKEALSEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PS3</accession>
    <name>Q73PS3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TSPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971335.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681961.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0723"/>
    <dbReference type="EnsemblBacteria" id="AAS11216">
        <property type="protein sequence ID" value="AAS11216"/>
        <property type="gene ID" value="TDE_0723"/>
    </dbReference>
    <dbReference type="GeneID" id="2740087"/>
    <dbReference type="KEGG" id="tde:TDE_0723"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.699"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040161_0_0_12"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="TSPc" evidence="2">
        <location>
            <begin position="186"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="425" mass="48490" checksum="E46417A72EEC7241" modified="2004-07-05" version="1">MKPDAKKKVEFFFICALVVLVISFFAFSIYLSKKEENGEFNFNSFKSGFISFEDCIADYEAFWDFIYNEYPFTEVCERKGADLKKIKEDGYKKIEYSAPIDSQNSYISFYAKLCEDITSRYFTGHLYPASISDYEYAMTVSDSYFKLYDVDLMNSFYRVKPSYSVNSLIGDRGVVKADTKIIEEGKIAYVRIDSFRKRGYAKEYIQYKKDMKKFFLDTEKYKHIIIDVSNNGGGDVKCYDSDILSYNNIGRNIQQRIYFLCSKNKYTELNPSFKNNQIDIKEVPNIKNANTKKNTIALYEEDAASFQELAPGYAPPKDRRYWLLISGKTASAADSLAGLCKASGFATLVGSNTGGLGHNGRHSPIYMMLPKSGLLIKFDPLYGLNSEGYCTDEFGTAPDIYNLPGKDALEACLEEIRKLGEKKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PY3</accession>
    <name>Q73PY3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971275.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681864.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0662"/>
    <dbReference type="EnsemblBacteria" id="AAS11156">
        <property type="protein sequence ID" value="AAS11156"/>
        <property type="gene ID" value="TDE_0662"/>
    </dbReference>
    <dbReference type="GeneID" id="2739210"/>
    <dbReference type="KEGG" id="tde:TDE_0662"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.642"/>
    <dbReference type="eggNOG" id="COG4115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169492_2_2_12"/>
    <dbReference type="OMA" id="KCRFHYD"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="87" mass="10464" checksum="1A40D5917D79885E" modified="2004-07-05" version="1">MIKAWDEDAWIDYVYWQTEDKKTLKRINMLIKDIERNGHNGLGSPEPLKGNLSEFWSRRIDKKNRLVYRIADNVIQIIQCRTHYGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PY6</accession>
    <name>Q73PY6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971272.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681855.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73PY6"/>
    <dbReference type="STRING" id="243275.TDE_0659"/>
    <dbReference type="EnsemblBacteria" id="AAS11153">
        <property type="protein sequence ID" value="AAS11153"/>
        <property type="gene ID" value="TDE_0659"/>
    </dbReference>
    <dbReference type="GeneID" id="2739207"/>
    <dbReference type="KEGG" id="tde:TDE_0659"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.639"/>
    <dbReference type="eggNOG" id="COG4283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133748_0_0_12"/>
    <dbReference type="OMA" id="HYDWAMK"/>
    <dbReference type="OrthoDB" id="1368382at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012550">
        <property type="entry name" value="DUF1706"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40658">
        <property type="entry name" value="PTHR40658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08020">
        <property type="entry name" value="DUF1706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031551">
        <property type="entry name" value="DUF1706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="170" mass="19998" checksum="8B548A293897E8CD" modified="2004-07-05" version="1">MPRPTTKEDLIFASNEQFEKLWNLIDGMTEKERTADINPNERDKNVRDVLVHLYEWHCLLLNWIKSNTKGKPAAFLPEAYNWKTYPEMNVEFWKKHQGTPYADAEKMLKKTHKEVMKLIETFSNEELFSKAVFNWTGTTTLGSYCVSATSSHYDWAIKDIKKALKKYRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PZ0</accession>
    <name>Q73PZ0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971268.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681847.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73PZ0"/>
    <dbReference type="STRING" id="243275.TDE_0655"/>
    <dbReference type="EnsemblBacteria" id="AAS11149">
        <property type="protein sequence ID" value="AAS11149"/>
        <property type="gene ID" value="TDE_0655"/>
    </dbReference>
    <dbReference type="GeneID" id="2739203"/>
    <dbReference type="KEGG" id="tde:TDE_0655"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.635"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_12"/>
    <dbReference type="OMA" id="SYPRRVW"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="232" mass="26862" checksum="6C284AE8C5419CB4" modified="2004-07-05" version="1">MKQLIKILIVEDDNTIASVLKKNLEQWNFNVRCAKNFSNILEEFEDYKPSLVIMDIGLPAFNGYHWCSEIRNKSQVPIIFLSSRNDKMDIVMAMQMGGDDYIEKPFDMDITIAKIQAVIRRTYQFTASMNEIGFAGTVLNLSTLTLVYNNKTTLLTANEIKILKCLYLAQGEFVSREKIMDVLWQNNQFVDDNTLSVNITRLRKKMENAELFNFIENKKGLGYKLNEHHGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QD2</accession>
    <name>Q73QD2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971125.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0511"/>
    <dbReference type="EnsemblBacteria" id="AAS11006">
        <property type="protein sequence ID" value="AAS11006"/>
        <property type="gene ID" value="TDE_0511"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0511"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.497"/>
    <dbReference type="HOGENOM" id="CLU_3298092_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="40" mass="4573" checksum="D72BEC78BFA44ADB" modified="2004-07-05" version="1">MASYKLKILEIRNSKAHIQCSGILIVDGYAELYEQEKFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QI4</accession>
    <name>Q73QI4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase_6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971073.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0459"/>
    <dbReference type="EnsemblBacteria" id="AAS10954">
        <property type="protein sequence ID" value="AAS10954"/>
        <property type="gene ID" value="TDE_0459"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0459"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.445"/>
    <dbReference type="eggNOG" id="ENOG5032XIK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062213_0_0_12"/>
    <dbReference type="OrthoDB" id="1335440at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024301">
        <property type="entry name" value="Amidase_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12671">
        <property type="entry name" value="Amidase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase_6" evidence="1">
        <location>
            <begin position="111"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="259" mass="29790" checksum="462BF6B4E8BC3B03" modified="2004-07-05" version="1">MKFNSVYQLPFVAGMKKAVEYFKDNKKALNQYNKRTTELKKYIGKTQIENNIFKITFTEKDNFENIKIEIATYLTKIDAFSLKPPEPEVLMQNGFDFIKYHVNTNSKKIDYNNAAAVIYANKYTSNPLNMSSDISVWNPEYKTYDNDCANYVSQCIYAGGISPTAAWYPESMIWIRTGSPRYTSSGITDYMQQKKIFYSTNYSAASEGGFICLIKESHVVFITSNDSITILFNGHTNDRKQVSFPHLHESEVIYLNPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QJ6</accession>
    <name>Q73QJ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971061.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681534.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0447"/>
    <dbReference type="EnsemblBacteria" id="AAS10942">
        <property type="protein sequence ID" value="AAS10942"/>
        <property type="gene ID" value="TDE_0447"/>
    </dbReference>
    <dbReference type="GeneID" id="2740429"/>
    <dbReference type="KEGG" id="tde:TDE_0447"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.434"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012254_0_0_12"/>
    <dbReference type="OMA" id="QWSVPAM"/>
    <dbReference type="OrthoDB" id="286400at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="111"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="417"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="634"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="680"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="759"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="781"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="992" mass="111602" checksum="DEB8F94EA8B4CC11" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QL3</accession>
    <name>Q73QL3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971044.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681488.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0430"/>
    <dbReference type="EnsemblBacteria" id="AAS10925">
        <property type="protein sequence ID" value="AAS10925"/>
        <property type="gene ID" value="TDE_0430"/>
    </dbReference>
    <dbReference type="GeneID" id="2739594"/>
    <dbReference type="KEGG" id="tde:TDE_0430"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.417"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003728_2_4_12"/>
    <dbReference type="OMA" id="MKKKMYD"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
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    </feature>
    <feature type="repeat" description="TPR" evidence="2">
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        </location>
    </feature>
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            <begin position="142"/>
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        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
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        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
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            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="338" mass="39936" checksum="A9CB149C12915DB8" modified="2004-07-05" version="1">MKSKNKFFITIIFLLILIYGCKTTNRDTTDTEKKQNYSQAEYFNIAGNTAKEKKDGTRAIYYYTKAIEADPAYIEAYLNRGEMYYYVNEHEKALADFDRIIELNPKEDKAYYFKGLLFNDAGNYNKAIENLNTAINLNDKDYEYYEARSRAYEQINEYEKAFEDINTAIKLNPKSAKLYNLRGRLHEHFERTDDAINDFKIAIKLDSNDIWPYNGLLFIYLEMDKNNEAFEIVNKMIKMKPSWIGILYGIRGTLFSMRGQYKEAIEDCNTGIRMYPHNASLYNIRGKIYFDLKEYKKAIKDFDMAIKFALENQNTEKQDAIEYKQKAYEALTEMEQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QN0</accession>
    <name>Q73QN0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971027.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0413"/>
    <dbReference type="EnsemblBacteria" id="AAS10908">
        <property type="protein sequence ID" value="AAS10908"/>
        <property type="gene ID" value="TDE_0413"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0413"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.400"/>
    <dbReference type="eggNOG" id="ENOG5031D3T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059390_0_0_12"/>
    <dbReference type="OrthoDB" id="2107187at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010103">
        <property type="entry name" value="Clustered_lipoprot_TREDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09710">
        <property type="entry name" value="Trep_dent_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285902" evidence="2">
        <location>
            <begin position="23"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="316" mass="36808" checksum="0EE186CCC7D6BBF9" modified="2004-07-05" version="1">MKKNKLKLIFILILAAFLFSCSKEIKEQKPEETKVESSAKTELPTQETQAKEEADLKTKNLTEKLAEESKTYLLRNLNGGPSSGFMSRSTPYRSNDEHYYKEGSLLFYNLNINDTYDEVVSKLRKFGVDGFYPASIIMPKELQELGCKAYIPDDSSYKRDLSNDFYIIFKDNKIIRFIKYQAEHTAFEKFYNAGTSNKLTIVDDMKTDSSGYDYYKKEMGGVIYHNQHYLPTALTTVVMTRVGYESYFEKADKIADEIFEFGDLYFYGLNIKDNIEIVKQKMNKFNVDYEDEFFSYHSTSVNLDDFIYALKTKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QN5</accession>
    <name>Q73QN5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase, NAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="5">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PyrK family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971022.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676763.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0408"/>
    <dbReference type="EnsemblBacteria" id="AAS10903">
        <property type="protein sequence ID" value="AAS10903"/>
        <property type="gene ID" value="TDE_0408"/>
    </dbReference>
    <dbReference type="GeneID" id="2740154"/>
    <dbReference type="KEGG" id="tde:TDE_0408"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.395"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_1_0_12"/>
    <dbReference type="OMA" id="AGQFIIL"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS10903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="278" mass="30436" checksum="D461E3309767BE2B" modified="2004-07-05" version="1">MHKILEKRQYSPEVFYLRVEAPEIAKNRHPGQFVIVQIDTNFGERVPLTIADANAEEGWIALVIQAVGATTIKLCNKNVGDSIAAILGPLGRPSHITKCGTVACVCGGIGVAPMYPIAQAFKKAGNKLIVIIGARNKDLIVFEDEMKAIADELIITTDDGSYGRKALVTVPLKELCESQTPPDEVFAIGPPIMMKFCAETTRPFGIKTTVSLNTIMIDGTGMCGGCRVTVDNQIKFVCVDGPEFDAHKVDFDNMMMRMKAFRGREDQDRHKCKSGIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QX1</accession>
    <name>Q73QX1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Regulatory protein, P-II family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970936.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0322"/>
    <dbReference type="EnsemblBacteria" id="AAS10817">
        <property type="protein sequence ID" value="AAS10817"/>
        <property type="gene ID" value="TDE_0322"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0322"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.311"/>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159089_0_0_12"/>
    <dbReference type="OMA" id="MHFKLII"/>
    <dbReference type="OrthoDB" id="1699192at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="99" mass="10735" checksum="254477E33D413F27" modified="2004-07-05" version="1">MKSAIFTVVNRGKASEVVDASLEAGARGGTIIHARGSGLNQTKLIFDMEIEPEKEIVLTIVDDDQLENVVEAIRKKSDVEKEGHGILFVIPVSKAYGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QZ2</accession>
    <name>Q73QZ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tetracenomycin polyketide synthesis O-methyltransferase TcmP, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970915.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956712.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0301"/>
    <dbReference type="EnsemblBacteria" id="AAS10796">
        <property type="protein sequence ID" value="AAS10796"/>
        <property type="gene ID" value="TDE_0301"/>
    </dbReference>
    <dbReference type="GeneID" id="2740288"/>
    <dbReference type="KEGG" id="tde:TDE_0301"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.289"/>
    <dbReference type="eggNOG" id="COG3315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069348_0_1_12"/>
    <dbReference type="OMA" id="LQYHRYA"/>
    <dbReference type="OrthoDB" id="847145at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016874">
        <property type="entry name" value="TcmP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028177">
        <property type="entry name" value="Polyketide_synth_Omtfrase_TcmP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="267" mass="30714" checksum="59404C8C8D781829" modified="2004-07-05" version="1">MSTKNLLDGVEDTLYIPLAARIYASEKFPKFFYDEKALSLKQYIPTDNIEKNTTEYFYMASVCRQQTIDKKIKKFLEENIQSNVVFLGAGLETAYNRINNVKSNFYQIDLPNVIDTRKKVLGNADNEKLISGDMFTLDWVKEIDTLLPTMIVVSGVYQYFDEGKIIEMIKKMKSLILKGELVFDATNSTGLKLANKYVQKTGNVNAKMYFSVDNPKEFANITNTKLIDVDGFFDGALKHCEGLKFLTRIYMYFADKLHRTLVVHLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R35</accession>
    <name>Q73R35_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970872.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956706.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0257"/>
    <dbReference type="EnsemblBacteria" id="AAS10753">
        <property type="protein sequence ID" value="AAS10753"/>
        <property type="gene ID" value="TDE_0257"/>
    </dbReference>
    <dbReference type="GeneID" id="2739682"/>
    <dbReference type="KEGG" id="tde:TDE_0257"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.252"/>
    <dbReference type="eggNOG" id="ENOG502Z9V0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093450_0_0_12"/>
    <dbReference type="OrthoDB" id="1668819at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011733">
        <property type="entry name" value="CHP02185_IM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09605">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02185">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="200" mass="22838" checksum="6A54849DA98BF662" modified="2004-07-05" version="1">MNTTAKWTIKDVITTVLLSALLVVMQFIVNMVCMANHFVSMTLSVGFSVFICAPVYFLMVQRVGKRGVSFIYMTLLGIIFLIMGNWYLLPYYIIIGLICEAVLWKHGAYQNPRRLMAAWTVSSLLFNGTNLLPIWFFWDAYYAFAVSSGMSQEYIDSYVRYFTVPYWIIFIVAFTTVCGFAGSLIASRLIKKHFEKAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R65</accession>
    <name>Q73R65_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970842.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681130.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0226"/>
    <dbReference type="EnsemblBacteria" id="AAS10723">
        <property type="protein sequence ID" value="AAS10723"/>
        <property type="gene ID" value="TDE_0226"/>
    </dbReference>
    <dbReference type="GeneID" id="2740780"/>
    <dbReference type="KEGG" id="tde:TDE_0226"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.219"/>
    <dbReference type="eggNOG" id="ENOG5031DCQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2358830_0_0_12"/>
    <dbReference type="OrthoDB" id="2002640at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="99" mass="11658" checksum="0C12BB228C9A3CC7" modified="2004-07-05" version="1">MDYVFVKDTEGFVVKKLKSQVECDEIIISEAEYKKLSGDNYYEFHFGHGGKRPGAGRKQKLGSPLKFQIRVTEEEKEFISYAREHNFDYKKVMEQKNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R75</accession>
    <name>Q73R75_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970832.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681116.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0216"/>
    <dbReference type="EnsemblBacteria" id="AAS10713">
        <property type="protein sequence ID" value="AAS10713"/>
        <property type="gene ID" value="TDE_0216"/>
    </dbReference>
    <dbReference type="GeneID" id="2741122"/>
    <dbReference type="KEGG" id="tde:TDE_0216"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.209"/>
    <dbReference type="eggNOG" id="COG2263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031012_1_0_12"/>
    <dbReference type="OMA" id="CGYETKV"/>
    <dbReference type="OrthoDB" id="880894at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="2">
        <location>
            <begin position="163"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="411" mass="47569" checksum="6E4F02084CC7EC53" modified="2004-07-05" version="1">MNTVSIEKAAELCIEHNIISGFFSKPAKKDSHIQKIKLRKIMLKNQEQYQLEIFEAAKVFHKNLLPQNLQKELEGLFFEFKIAEFNSSNNQLIFLQNNKGVIHFKTKPIKKEKLLKKGNASINESFEHNKQKEYILSTSKMPLFLKKLNFFTDDGKIIQSKYHKFRQINKYLEFIKSVLPELKDILKEKEKLQIVDFGCGKAYLSFALYYYLNEIEKLPVRICGLDLKEDVIDFCNKLSRECRFANLTFEVGDIGRFKFDTPPDMVISLHACDTATDLAIAKAVKSNTKIIFAVPCCQHELNTQIRKNKEKIIKSLSPILDYGIITEKFASLLTDTIRGKLLESEGYKVSVEEFIETEHTPKNILIKAVKLDNKAKNKTLLIEKAKKEFKEIKQAFLIEPCLEKLLSENQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R85</accession>
    <name>Q73R85_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Surface antigen, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS10703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0206"/>
    <dbReference type="EnsemblBacteria" id="AAS10703">
        <property type="protein sequence ID" value="AAS10703"/>
        <property type="gene ID" value="TDE_0206"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0206"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.200"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022366_0_0_12"/>
    <dbReference type="OMA" id="YCHENEL"/>
    <dbReference type="OrthoDB" id="334034at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="618" mass="71277" checksum="AE7FA534C4312E42" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RB1</accession>
    <name>Q73RB1_TREDE</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="243275.TDE_0180"/>
    <dbReference type="EnsemblBacteria" id="AAS10677">
        <property type="protein sequence ID" value="AAS10677"/>
        <property type="gene ID" value="TDE_0180"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0180"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.176"/>
    <dbReference type="HOGENOM" id="CLU_3049073_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="54" mass="6471" checksum="D7F021285985B36D" modified="2004-07-05" version="1">MWKKLGNLKCKPVLFLLNFWMMFFYLLKEALESSEKLKKILLKLAVCGKAWYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RF1</accession>
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        <submittedName>
            <fullName evidence="2">Alkyldihydroxyacetonephosphate synthase, putative</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0138</name>
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    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970755.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681003.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0138"/>
    <dbReference type="EnsemblBacteria" id="AAS10636">
        <property type="protein sequence ID" value="AAS10636"/>
        <property type="gene ID" value="TDE_0138"/>
    </dbReference>
    <dbReference type="GeneID" id="2739342"/>
    <dbReference type="KEGG" id="tde:TDE_0138"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.138"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_2_0_12"/>
    <dbReference type="OMA" id="PRCHDEV"/>
    <dbReference type="OrthoDB" id="1188552at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD_binding_4"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="121"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="586" mass="66704" checksum="6643A3D9C9AEFF8A" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RM3</accession>
    <name>Q73RM3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
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            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
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            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="RefSeq" id="WP_002680919.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0065"/>
    <dbReference type="EnsemblBacteria" id="AAS10563">
        <property type="protein sequence ID" value="AAS10563"/>
        <property type="gene ID" value="TDE_0065"/>
    </dbReference>
    <dbReference type="GeneID" id="2741680"/>
    <dbReference type="KEGG" id="tde:TDE_0065"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.66"/>
    <dbReference type="eggNOG" id="COG1430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097039_1_2_12"/>
    <dbReference type="OMA" id="FWMKNVP"/>
    <dbReference type="OrthoDB" id="1934378at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
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    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004286071" evidence="1">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="174" mass="20361" checksum="4D06D506C300A669" modified="2004-07-05" version="1">MIFKKVIIVFLMLCFFASCSSQNKMETEDIFIEKISREETEETNEEAKTEESVKKNIEKISVELAITPAQQQRGFMERKLIPEGTGMIFLYKEDTKLRFWMKNTPHPLSIAFIDSSGIIKEIYDMTPYSLETVESTYSVRYALEVPQGMFKRMDIKEGDKLTQETIFLLKRKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RQ4</accession>
    <name>Q73RQ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970648.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666892.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0031"/>
    <dbReference type="EnsemblBacteria" id="AAS10529">
        <property type="protein sequence ID" value="AAS10529"/>
        <property type="gene ID" value="TDE_0031"/>
    </dbReference>
    <dbReference type="GeneID" id="2741646"/>
    <dbReference type="KEGG" id="tde:TDE_0031"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.33"/>
    <dbReference type="eggNOG" id="ENOG503325H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184192_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="86" mass="8468" checksum="B60DCA6D55EBD1F7" modified="2004-07-05" version="1">MAVASLVLGIIALVIGVVSGGSLGWFGSILAILGIIFGALGRKNPESKGISTAGLVLSIIALLLGVILWIACFACLAGTAAALSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7IWN1</accession>
    <name>F7IWN1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Motility protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">motA</name>
        <name evidence="10" type="ordered locus">TDE_2766</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MotA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973364.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666986.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2766"/>
    <dbReference type="EnsemblBacteria" id="AAS13283">
        <property type="protein sequence ID" value="AAS13283"/>
        <property type="gene ID" value="TDE_2766"/>
    </dbReference>
    <dbReference type="GeneID" id="2740733"/>
    <dbReference type="KEGG" id="tde:TDE_2766"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2610"/>
    <dbReference type="eggNOG" id="COG1291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079895_1_0_12"/>
    <dbReference type="OMA" id="EIETHHQ"/>
    <dbReference type="OrthoDB" id="897037at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="100"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS13283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="259" mass="28291" checksum="E3109E71C2FC0FED" modified="2011-07-27" version="1">MDIASFIGIFGGIAVVAFGAILGGSAGGLIHPASMFITIGGSYMCLFLTYPLSYTIGIFKVVARVFKVTDYGEKALVQRFVALSEKSRRAGLLALEEEIEDFEDPFMRSGLRNVVDGIDGEAIRSLMENELNQMEERHNTWISLVNAWATLAPGFGMLGTVIGLIGMLLNLDDKTALGPNMATALVTTFYGSLMQNWLLVPIATKLMYQNNMEVKSKEMIIEGVLGIQAGDNPRILAQRLITYLTPSDRKAIEAEVLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J29</accession>
    <name>Q73J29_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type I site-specific deoxyribonuclease</fullName>
            <ecNumber evidence="3">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hsdR-2</name>
        <name evidence="12" type="ordered locus">TDE_2747</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HsdR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973345.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680808.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2747"/>
    <dbReference type="REBASE" id="6392">
        <property type="entry name" value="TdeVIIP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13264">
        <property type="protein sequence ID" value="AAS13264"/>
        <property type="gene ID" value="TDE_2747"/>
    </dbReference>
    <dbReference type="GeneID" id="2740714"/>
    <dbReference type="KEGG" id="tde:TDE_2747"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2593"/>
    <dbReference type="eggNOG" id="COG4096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007363_1_0_12"/>
    <dbReference type="OMA" id="QMIGRAT"/>
    <dbReference type="OrthoDB" id="16977at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013670">
        <property type="entry name" value="EcoEI_R_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08463">
        <property type="entry name" value="EcoEI_R_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="186"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS13264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="934" mass="105985" checksum="569D7646DF4E4666" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J51</accession>
    <name>Q73J51_TREDE</name>
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        <submittedName>
            <fullName evidence="3">Cyclic nucleotide binding domain/GGDEF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680778.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2725"/>
    <dbReference type="EnsemblBacteria" id="AAS13242">
        <property type="protein sequence ID" value="AAS13242"/>
        <property type="gene ID" value="TDE_2725"/>
    </dbReference>
    <dbReference type="GeneID" id="2740944"/>
    <dbReference type="KEGG" id="tde:TDE_2725"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2573"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_5_12"/>
    <dbReference type="OMA" id="AGDYALC"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
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        <property type="entry name" value="cNMP-bd_CS"/>
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    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
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    </dbReference>
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        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
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        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
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            <begin position="192"/>
            <end position="322"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="322" mass="36585" checksum="FEEC276546F2F2F1" modified="2004-07-05" version="1">MNSSKQRWLEILQKARLFAHLSIKEIEVLAEAMFYSEFEAGQALVYEGESGNELFIIVKGTISVSVKSEGKEIELVRLGAGDFFGEMAMLEQEHRSATCKAVESTSCLVLKSQDFSSLIIDQPKIASTVLYNMLKITGGRLSKTDGLLSQIIRWGDDAKRRAITDEFTGLYNRRYLDESFESLLKRCVRQHIGVSFAMVDIDHFGQLNRDYGAVFCDKVLLAIVEVFKRNFDTDDILIRYGGDEFSFIIRGMLERAEYQCKRVCTEVNALTFQEHPELRVSCSIGLAVYDEKMTTPELLKFSDTALYSAKEGGRNRVFVYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JE6</accession>
    <name>Q73JE6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptide ABC transporter, periplasmic peptide-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2629"/>
    <dbReference type="EnsemblBacteria" id="AAS13146">
        <property type="protein sequence ID" value="AAS13146"/>
        <property type="gene ID" value="TDE_2629"/>
    </dbReference>
    <dbReference type="GeneID" id="2740803"/>
    <dbReference type="KEGG" id="tde:TDE_2629"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2485"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_4_12"/>
    <dbReference type="OMA" id="YIPLTYQ"/>
    <dbReference type="OrthoDB" id="162819at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="83"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="517" mass="58509" checksum="432D350593E93F86" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JM4</accession>
    <name>Q73JM4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS12911">
        <property type="protein sequence ID" value="AAS12911"/>
        <property type="gene ID" value="TDE_2393"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2393"/>
    <dbReference type="HOGENOM" id="CLU_3359078_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="36" mass="4149" checksum="A33A209FD8F754C9" modified="2004-07-05" version="1">MRVSTPLAEKIGNRQTAKNMNSVLIFFIKNSHKNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JQ6</accession>
    <name>Q73JQ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973051.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680407.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2452"/>
    <dbReference type="EnsemblBacteria" id="AAS12970">
        <property type="protein sequence ID" value="AAS12970"/>
        <property type="gene ID" value="TDE_2452"/>
    </dbReference>
    <dbReference type="GeneID" id="2739637"/>
    <dbReference type="KEGG" id="tde:TDE_2452"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2320"/>
    <dbReference type="HOGENOM" id="CLU_182373_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="98" mass="11628" checksum="1A90B20D4EB8268A" modified="2004-07-05" version="1">MLHQYNLLSKELQQEVQHYIEYLFLKNKTLSKKTDEESIKETQADKISDTELFGINTEMVSDKKLFEVSNHLIKEKCSYENTETLELTDVQFYDNNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JR5</accession>
    <name>Q73JR5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hexokinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973067.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680422.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2469"/>
    <dbReference type="EnsemblBacteria" id="AAS12986">
        <property type="protein sequence ID" value="AAS12986"/>
        <property type="gene ID" value="TDE_2469"/>
    </dbReference>
    <dbReference type="GeneID" id="2739654"/>
    <dbReference type="KEGG" id="tde:TDE_2469"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2335"/>
    <dbReference type="eggNOG" id="COG5026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_3_12"/>
    <dbReference type="OMA" id="IAINCEW"/>
    <dbReference type="OrthoDB" id="926142at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004396">
        <property type="term" value="F:hexokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:cellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="PTHR19443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase_1" evidence="8">
        <location>
            <begin position="23"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase_2" evidence="9">
        <location>
            <begin position="207"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS12986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="437" mass="49041" checksum="9FC89118CA0F5A9E" modified="2004-07-05" version="1">MKEIDDFFKRNNFDYKIDIEYAASILLEDMKKGLESEAESVSSMDMIPLWKNLPTDIPKDKKVIIIDAGGTNFRAGIVYFDKKGVPEILSFFKHPMPALDREMTNEEFFDSIAEYLEPLKDESDMISFCFSYAIKIFPDGGGQAIKLSKEIKLPYIGDCKINEGLFQALSRKGWKKIKKIIMVNDTAAVLQSGIFSETDDQGFDSHIGFVLGTGLNSAYIEYGKIEKLKTTEFYDKPQIIVCESGKSNKIPQSKFDKILSENSNLKNEYFLERMCSGRYLGELCSIALRAGSAEGIFSPRVNKMLLNSCDFSTEEISLFLKEQNHDKNIFSGIIEAHSVSEDYVKIYSICKCFFERAGRLSAAVIAAACIKTGKGKSPDKPICISADGSMFLKGFLIKERIFKSLHTCLTEKRGIYFVLKTNDEAVTLGTALAAFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JT3</accession>
    <name>Q73JT3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arcC</name>
        <name evidence="4" type="ordered locus">TDE_2476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the carbamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973074.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680441.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2476"/>
    <dbReference type="EnsemblBacteria" id="AAS12993">
        <property type="protein sequence ID" value="AAS12993"/>
        <property type="gene ID" value="TDE_2476"/>
    </dbReference>
    <dbReference type="GeneID" id="2741449"/>
    <dbReference type="KEGG" id="tde:TDE_2476"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2342"/>
    <dbReference type="eggNOG" id="COG0549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076278_0_0_12"/>
    <dbReference type="OMA" id="QPMDVAG"/>
    <dbReference type="OrthoDB" id="901370at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00746">
        <property type="entry name" value="arcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="309" mass="32849" checksum="FC0A80E33FC60249" modified="2004-07-05" version="1">MPKKIVIALGGNALGNNLEEQRKAVKITAKAIADLAEEGHQVIVSHGNGPQVGMIHLAMSEYHKIDPKTSEPELAISVAMSQGYIGNDLEAALREELLNRGINKPVATLITQVLVDPSDPAFSKPTKPIGSFMTKEEADILTAKGENVVEDAGRGYRRVVASPKPIDIAEIESIRALCDAGQIVITCGGGGIPVVKKGNALCGVPAVIDKDFASAKLAQLLNADCLIILTAVEKVAINFNKPDQKWLSEISVAEAKKYIEEGHFAPGSMLPKVQAAIQFAESNKKGYALITLLEKAKDAIDGKSGTIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JT6</accession>
    <name>Q73JT6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973097.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667426.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2499"/>
    <dbReference type="EnsemblBacteria" id="AAS13016">
        <property type="protein sequence ID" value="AAS13016"/>
        <property type="gene ID" value="TDE_2499"/>
    </dbReference>
    <dbReference type="GeneID" id="2741472"/>
    <dbReference type="KEGG" id="tde:TDE_2499"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2366"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_1_0_12"/>
    <dbReference type="OMA" id="ACGKGRH"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="52"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="253" mass="28685" checksum="551F7D69EE3E51AC" modified="2004-07-05" version="1">MEKLADWFENETFWAEYAPIMFDTQRWAEAPTVAESILRIIGVPVDNAGISILDAGCGPGRIAIELAIRKAKVTGIDLIRPFLNAAMDSAQDEGVDIELIQGDLRKFVRPEGFDAAISMYTSFGYCSTIEEDMQILKNIAQSIKPNGWFILEMTGREIAVRDFTEGEWFERAGFTVLTEYSVEGAWEGLRSRWILYDEQGRKADHTYVQRLYSAVELKRLMLAAGFSSVEIYGDFDFSPYNEKARTMVLIARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JT9</accession>
    <name>Q73JT9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973094.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2496"/>
    <dbReference type="EnsemblBacteria" id="AAS13013">
        <property type="protein sequence ID" value="AAS13013"/>
        <property type="gene ID" value="TDE_2496"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2496"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2363"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_979832_0_0_12"/>
    <dbReference type="OMA" id="QNLMLSF"/>
    <dbReference type="OrthoDB" id="1286940at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS13013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="242" mass="26651" checksum="2F86716ABF7D74C5" modified="2004-07-05" version="1">MDNLQEKFETILSVFEEIQKESSSSASNANYVDEMLSNVLKRRTVIQEEIHERVDEIEATAENAENAASAFEVLKDRTAEVEDMLSGIKDVSVKTGILAINASIEAARAGSVGNGFRIIANEVRSLATQTGDFAKKIESKLEELNKSVDEINNSMTGFIELFSKFRKSFNGVLANLDENSATLKDAGFSLAEITASIKEQDITIREGFLSLKKIDNFLHDTSTILDAVQTSHEHLGTLLQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JY2</accession>
    <name>Q73JY2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973129.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673786.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2531"/>
    <dbReference type="EnsemblBacteria" id="AAS13048">
        <property type="protein sequence ID" value="AAS13048"/>
        <property type="gene ID" value="TDE_2531"/>
    </dbReference>
    <dbReference type="GeneID" id="2739043"/>
    <dbReference type="KEGG" id="tde:TDE_2531"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2395"/>
    <dbReference type="eggNOG" id="ENOG502ZWV7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198286_0_0_12"/>
    <dbReference type="OMA" id="YARAHNM"/>
    <dbReference type="OrthoDB" id="2047570at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045944">
        <property type="entry name" value="DUF6364"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19891">
        <property type="entry name" value="DUF6364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="74" mass="8903" checksum="A16F745639203072" modified="2004-07-05" version="1">MKKITLSLDEDIITAGQEYAKHQNISFNSLIRKLLEQTIHPQKNEWLDDTFSLMDKVYISSEKKQWTRDELYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JZ9</accession>
    <name>Q73JZ9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973164.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957266.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2566"/>
    <dbReference type="EnsemblBacteria" id="AAS13083">
        <property type="protein sequence ID" value="AAS13083"/>
        <property type="gene ID" value="TDE_2566"/>
    </dbReference>
    <dbReference type="GeneID" id="2739931"/>
    <dbReference type="KEGG" id="tde:TDE_2566"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2425"/>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014114_0_0_12"/>
    <dbReference type="OrthoDB" id="1081028at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284562" evidence="1">
        <location>
            <begin position="29"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="414"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="530"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="951" mass="106246" checksum="6FD1728125EB24FE" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K16</accession>
    <name>Q73K16_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS13092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS13092">
        <property type="protein sequence ID" value="AAS13092"/>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.2434"/>
    <dbReference type="eggNOG" id="COG3758">
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    </dbReference>
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        <property type="entry name" value="RmlC-like_jellyroll"/>
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        <property type="entry name" value="Uncharacterised_HutD/Ves"/>
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        <property type="entry name" value="PTHR37943"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF05962">
        <property type="entry name" value="HutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="204" mass="23166" checksum="7973BAABE19162B4" modified="2004-07-05" version="1">MKITHYREKDFKTSNWSGGTTTELFIYPREADYKKRDFLFRLSSATVDLDRSDFTPLPGFFRFISPLNGDLKISHDEKNFTKLKPYEVYAFDGGAKTVSMGRVRDFNLMVKDGVETEVKNFALNKNSVLKFSVSKGEIGWIFLYNTKALLSAETVNEKKDFNLDKLDLIIFEAGDDTNGDTKEEVLISADGALSLFYGKVPTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K34</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
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            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS13100">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="32" mass="3917" checksum="3EFD651CB248C0FD" modified="2004-07-05" version="1">MSIVFTKNIAKISFLEYSFICKYNLTYEEKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K77</accession>
    <name>Q73K77_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidate cytidylyltransferase</fullName>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cdsA</name>
        <name evidence="2" type="ordered locus">TDE_2343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.41" evidence="2"/>
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        <property type="protein sequence ID" value="AAS12861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972942.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667742.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2343"/>
    <dbReference type="EnsemblBacteria" id="AAS12861">
        <property type="protein sequence ID" value="AAS12861"/>
        <property type="gene ID" value="TDE_2343"/>
    </dbReference>
    <dbReference type="GeneID" id="2739438"/>
    <dbReference type="KEGG" id="tde:TDE_2343"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2211"/>
    <dbReference type="eggNOG" id="COG0575">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037294_3_1_12"/>
    <dbReference type="OMA" id="FTFDEVG"/>
    <dbReference type="OrthoDB" id="1533756at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="285" mass="31497" checksum="4EC918DF17751D60" modified="2004-07-05" version="1">MKIKKLIERLIIFFVGAPLVLASIYFLPHYNFLVYHIELFIAALIANYEIYNILSQRSPAYPKKILACFGTILVLSSYLIGLHAVPFQYIFIVFGCVTVGMMFMEVIFSFSGNFTNSIARLTTGVFMLIYPWGLTVFLSAIASLPNAGALIIMFFLMTFGCDSFAWLFGMLLGKNNRGFIKASPKKSIVGFIGGFIGSITAAVASFYFFNKQFNGKLRELIIIALFTALFAIIGDIIESILKRSADVKDSGKVILGRGGILDSIDSLLIAAPVFYTLCMFLLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K98</accession>
    <name>Q73K98_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972921.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680234.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2321"/>
    <dbReference type="EnsemblBacteria" id="AAS12840">
        <property type="protein sequence ID" value="AAS12840"/>
        <property type="gene ID" value="TDE_2321"/>
    </dbReference>
    <dbReference type="GeneID" id="2739416"/>
    <dbReference type="KEGG" id="tde:TDE_2321"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2190"/>
    <dbReference type="eggNOG" id="ENOG5031CXK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155178_0_0_12"/>
    <dbReference type="OMA" id="NPGSDYK"/>
    <dbReference type="OrthoDB" id="2001527at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="117" mass="12671" checksum="EA4260F94E30CAE5" modified="2004-07-05" version="1">MNGQPVAAAQVIIAVVPIVGIVMAGVLIFFYLFWRNKQIICQIQTKTYIPIKFNLSGFCLISGILLLMIGSVLTILFSVIDGLSYVLLGGLVPLSCGIGLLLYYFISSKGKKGDAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KC9</accession>
    <name>Q73KC9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribulokinase/uridine kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972889.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674349.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2289"/>
    <dbReference type="EnsemblBacteria" id="AAS12808">
        <property type="protein sequence ID" value="AAS12808"/>
        <property type="gene ID" value="TDE_2289"/>
    </dbReference>
    <dbReference type="GeneID" id="2740254"/>
    <dbReference type="KEGG" id="tde:TDE_2289"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2159"/>
    <dbReference type="eggNOG" id="COG0572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023775_1_0_12"/>
    <dbReference type="OMA" id="DDHNRIP"/>
    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="283"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="550" mass="62375" checksum="D5BB28A09F52B8A7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KD0</accession>
    <name>Q73KD0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972888.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2288"/>
    <dbReference type="EnsemblBacteria" id="AAS12807">
        <property type="protein sequence ID" value="AAS12807"/>
        <property type="gene ID" value="TDE_2288"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2288"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2158"/>
    <dbReference type="eggNOG" id="ENOG5032MJ1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139825_0_0_12"/>
    <dbReference type="OrthoDB" id="2117216at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="160" mass="18422" checksum="8E292B9019F43D81" modified="2004-07-05" version="1">MKKFLVVLFLFVTVFAYSFKYENYQEMSINDLVKMVESAAKENEDGGLTIFNSFIGLPVTLDEYPSAEKDKKYEQEIRMFTYWFEMPENFFGSVITNKLPNGYELVMVFQNSIAQHLKNDVKKGEKIGVYAFLGGYDSSSKRILIMVSAFNTKADYKGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KD8</accession>
    <name>Q73KD8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglycosylase, SLT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972880.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680167.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2280"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12799">
        <property type="protein sequence ID" value="AAS12799"/>
        <property type="gene ID" value="TDE_2280"/>
    </dbReference>
    <dbReference type="GeneID" id="2740030"/>
    <dbReference type="KEGG" id="tde:TDE_2280"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2150"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022873_0_0_12"/>
    <dbReference type="OMA" id="QRDACIW"/>
    <dbReference type="OrthoDB" id="859969at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="1">
        <location>
            <begin position="533"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="688" mass="79016" checksum="36CA956481CE8E52" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KE5</accession>
    <name>Q73KE5_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2273</name>
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    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972873.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2273"/>
    <dbReference type="EnsemblBacteria" id="AAS12792">
        <property type="protein sequence ID" value="AAS12792"/>
        <property type="gene ID" value="TDE_2273"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2273"/>
    <dbReference type="HOGENOM" id="CLU_3405981_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3661" checksum="99A3447CD1F263AF" modified="2004-07-05" version="1">MFYGSKKSAKQQLEKSLLVWIFFSFYNLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KI3</accession>
    <name>Q73KI3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylaspartate ammonia-lyase</fullName>
            <ecNumber evidence="6">4.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">TDE_2235</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12829"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:36986"/>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
            <dbReference type="EC" id="4.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methylaspartate ammonia-lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.2" evidence="6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972835.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680089.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2235"/>
    <dbReference type="EnsemblBacteria" id="AAS12754">
        <property type="protein sequence ID" value="AAS12754"/>
        <property type="gene ID" value="TDE_2235"/>
    </dbReference>
    <dbReference type="GeneID" id="2741340"/>
    <dbReference type="KEGG" id="tde:TDE_2235"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2111"/>
    <dbReference type="eggNOG" id="COG3799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055277_0_0_12"/>
    <dbReference type="OMA" id="RIEGPMD"/>
    <dbReference type="OrthoDB" id="254720at2"/>
    <dbReference type="UniPathway" id="UPA00561">
        <property type="reaction ID" value="UER00618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050096">
        <property type="term" value="F:methylaspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019553">
        <property type="term" value="P:glutamate catabolic process via L-citramalate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03314">
        <property type="entry name" value="MAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006395">
        <property type="entry name" value="Me_Asp_am_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022662">
        <property type="entry name" value="MeAsp_NH4-lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022665">
        <property type="entry name" value="MeAsp_NH4-lyase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07476">
        <property type="entry name" value="MAAL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05034">
        <property type="entry name" value="MAAL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017107">
        <property type="entry name" value="MAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00007">
        <property type="entry name" value="methylaspartate_ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01502">
        <property type="entry name" value="B_methylAsp_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAAL_N" evidence="14">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="MAAL_C" evidence="15">
        <location>
            <begin position="162"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>(2S,3S)-3-methyl-L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>(2S,3S)-3-methyl-L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AAS12754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="412" mass="45610" checksum="0158572EABC13FF6" modified="2004-07-05" version="1">MKIVDVVCAEGKTGFYFDDQKAIKMGAGHDGFFYTGKPVTEGFTSIRQAGEAISVMFILEDGQVAYGDCAAVQYSGAGGRDPLFLAKDFIPVIEKDIKPLFVGKEITNFREMAKTFEEHKVNGKRMHTALRYGISQAILDAVAKSQHITMAEVVVKEYNTGCQIKRIPIFTQSGDDRYLNADKMIIKQAEVLPHGLFNNVEEKTGKNGEKLLEYVKWLKNRVETMRTCKNYNPIFHIDVYGTIGDFTNNDVPKMTAYLKTLESAAAPFKLRIEGPMDMGDREKQMQVLAALTKSLDDNGVKVELVADEWCNTLEDIQYFADNRAGHMIQIKTPDLGGINNTIEAILYCKEKGVGAYCGGTCNETNRSAEVIVNCSVAAGAAQQLAKPGMGVDEGYMIINNEMNRIVALANRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KK1</accession>
    <name>Q73KK1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose/glucose-binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mglB</name>
        <name evidence="4" type="ordered locus">TDE_2217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972817.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674469.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2217"/>
    <dbReference type="EnsemblBacteria" id="AAS12736">
        <property type="protein sequence ID" value="AAS12736"/>
        <property type="gene ID" value="TDE_2217"/>
    </dbReference>
    <dbReference type="GeneID" id="2739493"/>
    <dbReference type="KEGG" id="tde:TDE_2217"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2094"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057130_0_0_12"/>
    <dbReference type="OMA" id="HNDSKAR"/>
    <dbReference type="OrthoDB" id="351138at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040740">
        <property type="entry name" value="MglB-2_Peripla_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18610">
        <property type="entry name" value="Peripla_BP_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="2">
        <location>
            <begin position="36"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_7" evidence="3">
        <location>
            <begin position="324"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="403" mass="42722" checksum="5972741D7DE4D3E1" modified="2004-07-05" version="1">MRSFSKFAQIVFFGLLIVSAIFVVSCGGSGNAVLNKDKPLVFFNRQPSDPTTGEIDMTSMNWNDKTYYVGFDAAGGGAVQGKLITDFLVSAETSLDRNGDGIIGYVLCIGDVGHNDSKARTEGIRKALGTWAGSTDPGKTKQGSITIAGKTFDVVELEGKAMTGTDGSTWNANAATEAMGGWATKFADQIDMVVSNNDGMAMGCLQASNYPAGVPIFGYDANADAIEAVGKGLLTGTVSQNVDAQATATLQVLRNLLDGLTGTDVYTKGITAEDSYGNKISAPVQYWADVKAVMAANSGVTKANYENYLGGTRDAGIKQTNAPKKKVLLTIYNSGDNFLSSSYLPALKYYAPLLNIELTIVQGDGQNESSCLDKFTNLNNFDAFAVNMVKTNSGSNYTDKLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KL0</accession>
    <name>Q73KL0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972808.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680051.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2208"/>
    <dbReference type="EnsemblBacteria" id="AAS12727">
        <property type="protein sequence ID" value="AAS12727"/>
        <property type="gene ID" value="TDE_2208"/>
    </dbReference>
    <dbReference type="GeneID" id="2739484"/>
    <dbReference type="KEGG" id="tde:TDE_2208"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2085"/>
    <dbReference type="eggNOG" id="COG0327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037423_3_0_12"/>
    <dbReference type="OMA" id="HGLFWRG"/>
    <dbReference type="OrthoDB" id="502462at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="259" mass="28787" checksum="40264255D3357F74" modified="2004-07-05" version="1">MKLKELDLYFTELLNIDAFAAQDLSQNGVQVQNSGKEIKKVAFAVDACLQSIKEAAERKADMLFVHHGLFWSRSLRIMGNHYHRIKALLDNDIVLYAVHLPLDAHPLYGNNIGLARRLELENLKEFGMYRGLNIGFYGSLPLKEGSEEGLELDEIINKLFPQGEKPANILPFGPKKIKTIGIISGGAASEIDDAIALGLDLYITGEIEHITYHNALENRINVIAGGHYQTETVGVQLVAKKLELDTNLETCFIDIPTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KM2</accession>
    <name>Q73KM2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA pseudouridylate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972796.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680039.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2195"/>
    <dbReference type="EnsemblBacteria" id="AAS12715">
        <property type="protein sequence ID" value="AAS12715"/>
        <property type="gene ID" value="TDE_2195"/>
    </dbReference>
    <dbReference type="GeneID" id="2740217"/>
    <dbReference type="KEGG" id="tde:TDE_2195"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2072"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_11_2_12"/>
    <dbReference type="OMA" id="FCENYLE"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="236" mass="27154" checksum="31C6C0FBC5D864F6" modified="2004-07-05" version="1">MHNEVRILFEDNFFAVVLKNCGDNSQVFFKKAFSEKKYAEAVNRLDKPVSGLVLIAFSPAMHTKLNNLFKEKKIKKEYWAICKKIEELKSAADSKISDTTPVLYKKEFCENYLEFNTKIQKAFVTESRQRGKKASLYWQLAGIGDNYNFLRIFPETGRTHQIRIQLSHLGMPIKGDIKYGFARTEKSGGIRLHAQSLKFEHPESKKRIEISALPPSPDTLWSACIEVCLKAKELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KP2</accession>
    <name>Q73KP2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972776.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680022.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2175"/>
    <dbReference type="EnsemblBacteria" id="AAS12695">
        <property type="protein sequence ID" value="AAS12695"/>
        <property type="gene ID" value="TDE_2175"/>
    </dbReference>
    <dbReference type="GeneID" id="2740197"/>
    <dbReference type="KEGG" id="tde:TDE_2175"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2053"/>
    <dbReference type="eggNOG" id="ENOG503312I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206660_0_0_12"/>
    <dbReference type="OrthoDB" id="2024628at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026990">
        <property type="entry name" value="TnpW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14202">
        <property type="entry name" value="TnpW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="60" mass="7060" checksum="EA9BE052326BED44" modified="2004-07-05" version="1">MAENEKTDIKEIQTEEHQKPDGILTKKINGKTFVTEIYFDKKSKETFQDKMFKVIHSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KQ5</accession>
    <name>Q73KQ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOL1/NOP2/sun family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972763.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679999.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2162"/>
    <dbReference type="EnsemblBacteria" id="AAS12682">
        <property type="protein sequence ID" value="AAS12682"/>
        <property type="gene ID" value="TDE_2162"/>
    </dbReference>
    <dbReference type="GeneID" id="2739148"/>
    <dbReference type="KEGG" id="tde:TDE_2162"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2042"/>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041061_0_0_12"/>
    <dbReference type="OMA" id="KAWGPMF"/>
    <dbReference type="OrthoDB" id="1064993at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="PTHR22808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="73"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="263" mass="30329" checksum="BD910814D1757B43" modified="2004-07-05" version="1">MKKQKLSGAEGFESYYLSIFGERWQSLKAALLEERKPEAYSENLIQNYYLDYASIQAARAMPVLEEGSCLDMCAAPGGKTLVLLSRIKENAEIQANELSADRRNRLIRVLDEHLSEETRKRIRVSSYDASRMPRYGQELYDRILLDAPCSSERHVLQNEKYLKQWTEARIKNLSQRQWALLSAAFLLLKPKGFLVYSTCALADEENDFLIEKLIKKYKEKVRLEEKLDGLGPISPEKTRYGFRFLPDKAEGAGPIYFSLIQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KX2</accession>
    <name>Q73KX2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972696.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2095"/>
    <dbReference type="EnsemblBacteria" id="AAS12615">
        <property type="protein sequence ID" value="AAS12615"/>
        <property type="gene ID" value="TDE_2095"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2095"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1978"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_1_2_12"/>
    <dbReference type="OMA" id="AGWAVRY"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="484" mass="54334" checksum="8648B17AFC38C90B" modified="2004-07-05" version="1">MKAQTANGFPSVQLVVVKNGRMIKNSAYGYISTVDDFGEPLMQKNKKPITKETLFDLASNTKMYTVNFALQKLISEEKISIYDKVQDFFPDFKDKKKALFKGKSDITVEDLLKHQAGFPAGAQYYVNKKITQKKKTDKRQNKEIVLELICNTPLIYSPRTEVLYSDIDYMLLGLIIEKVTGLPLDKYTEENLYKPLNLSSICYEPLKKGFTKEDITATEIRAVKRTKDEKFKDIKYMPVHGTVHDPEAYNAMDQVSGHAGLFANAESIAVLAQVMLNGGGYGNIKLFDSSVLNLFTSQGNFFSQAGLGWRRQGLNNSYAWAFSQLASADTIGHTGWTGTLTLIDPKEDLIIIIFTSAKNTPALFGRNLRGKYEGDFYLAKNYGAVTTLIYSAFKNYDNAMLDQMLIELAVGRNELINMIPEIYDNEGSRKDLTAIMESIKEQSKQSAILRKFLKSEKAAAILAEIQSRNSKKSLAKKQAEGQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KX4</accession>
    <name>Q73KX4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972694.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2093"/>
    <dbReference type="EnsemblBacteria" id="AAS12613">
        <property type="protein sequence ID" value="AAS12613"/>
        <property type="gene ID" value="TDE_2093"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2093"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1977"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102849_0_0_12"/>
    <dbReference type="OMA" id="WEEEYFI"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="177" mass="20130" checksum="3E15151618C0C0C7" modified="2004-07-05" version="1">MQKASAEILDKLIKPVSSITGSHHEGFLLTAGCGTEREQWNTMTAGWGSIGFLWNKLTATVYVRPTRYTSEFIDKEDYITLSFFDKNDPWARNALAFCGSVSGRNVDKARETGLKPVMLDDGVIAFEQAKVVLSCRKLYRSEFDMDLFVDPQIIIDSYPKKDFHYVYICEIVSVYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L03</accession>
    <name>Q73L03_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">feoB</name>
        <name evidence="13" type="ordered locus">TDE_2063</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972665.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679857.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2063"/>
    <dbReference type="EnsemblBacteria" id="AAS12576">
        <property type="protein sequence ID" value="AAS12576"/>
        <property type="gene ID" value="TDE_2063"/>
    </dbReference>
    <dbReference type="GeneID" id="2741190"/>
    <dbReference type="KEGG" id="tde:TDE_2063"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1947"/>
    <dbReference type="eggNOG" id="COG0370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013350_1_0_12"/>
    <dbReference type="OrthoDB" id="304844at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0410">Iron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="425"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="918"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="12">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS12576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="944" mass="105128" checksum="BA5462684DA4457E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L43</accession>
    <name>Q73L43_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972625.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957129.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2022"/>
    <dbReference type="EnsemblBacteria" id="AAS12536">
        <property type="protein sequence ID" value="AAS12536"/>
        <property type="gene ID" value="TDE_2022"/>
    </dbReference>
    <dbReference type="GeneID" id="2740369"/>
    <dbReference type="KEGG" id="tde:TDE_2022"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1908"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004358_0_1_12"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022045">
        <property type="entry name" value="TcdB_toxin_mid/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12256">
        <property type="entry name" value="TcdB_toxin_midN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="TcdB_toxin_midN" evidence="3">
        <location>
            <begin position="171"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1053"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1488" mass="170911" checksum="7052CEADF162EDB6" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L63</accession>
    <name>Q73L63_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972605.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679755.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2002"/>
    <dbReference type="EnsemblBacteria" id="AAS12516">
        <property type="protein sequence ID" value="AAS12516"/>
        <property type="gene ID" value="TDE_2002"/>
    </dbReference>
    <dbReference type="GeneID" id="2740455"/>
    <dbReference type="KEGG" id="tde:TDE_2002"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1891"/>
    <dbReference type="eggNOG" id="ENOG5031NIM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1383645_0_0_12"/>
    <dbReference type="OrthoDB" id="1838410at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="198" mass="22982" checksum="33B30E6DE57FDB9E" modified="2004-07-05" version="1">MKEIYGTVYDKNNKPLEKALVALLNNKFEIEYSDETNNEGKFNLSAEPKYYPFFIAVKEYKENYLEYWSQNIDLDEDLEINPKIDVIEIYGLHCFQVKGAGNYLMVYFRPMSLTKFKANEKNIVPDIGKESLTVSVNGEFCEILTLSRVEEQFPDTQMTSFLMQISMDGVKFSDKNKLELSITDRNGDYGEASIFFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LE6</accession>
    <name>Q73LE6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972522.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679625.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1919"/>
    <dbReference type="EnsemblBacteria" id="AAS12433">
        <property type="protein sequence ID" value="AAS12433"/>
        <property type="gene ID" value="TDE_1919"/>
    </dbReference>
    <dbReference type="GeneID" id="2740417"/>
    <dbReference type="KEGG" id="tde:TDE_1919"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1816"/>
    <dbReference type="eggNOG" id="COG0731">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035710_0_0_12"/>
    <dbReference type="OMA" id="REPKNTY"/>
    <dbReference type="OrthoDB" id="408907at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027608">
        <property type="entry name" value="Spiro_SPASM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04321">
        <property type="entry name" value="spiroSPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPASM" evidence="1">
        <location>
            <begin position="453"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="523" mass="59687" checksum="7F26C8EF5673C875" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LF2</accession>
    <name>REX_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rex</name>
        <name type="ordered locus">TDE_1912</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972515.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669725.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73LF2"/>
    <dbReference type="SMR" id="Q73LF2"/>
    <dbReference type="STRING" id="243275.TDE_1912"/>
    <dbReference type="EnsemblBacteria" id="AAS12426">
        <property type="protein sequence ID" value="AAS12426"/>
        <property type="gene ID" value="TDE_1912"/>
    </dbReference>
    <dbReference type="GeneID" id="2740410"/>
    <dbReference type="KEGG" id="tde:TDE_1912"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1809"/>
    <dbReference type="eggNOG" id="COG2344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061534_1_0_12"/>
    <dbReference type="OMA" id="HEQRKAG"/>
    <dbReference type="OrthoDB" id="1872374at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000073049" description="Redox-sensing transcriptional repressor Rex">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="17"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="91"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <sequence length="210" mass="23128" checksum="90C7DEF3481ED700" modified="2004-07-05" version="1">MAKQKVPAAPSVRRLPSYLHLVKKAEADKLEYISGTVIAEELELEPIQVRKDLTITGIVGKPKKGYPVKLLITAIEKFLGWNKEKKAFVIGAGSLGTALSGYQGFKEHGLDICAAFDSDKRKIGKEIHELPVFGMDELETKVKEYKPEIAILTVPSKYAQEAANAIVKAGIKAIWNFTNIKITVPDKVIVQKEDLSSGYAMLGVMMNTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LF6</accession>
    <name>Q73LF6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972511.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669712.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73LF6"/>
    <dbReference type="STRING" id="243275.TDE_1908"/>
    <dbReference type="EnsemblBacteria" id="AAS12422">
        <property type="protein sequence ID" value="AAS12422"/>
        <property type="gene ID" value="TDE_1908"/>
    </dbReference>
    <dbReference type="GeneID" id="2740406"/>
    <dbReference type="KEGG" id="tde:TDE_1908"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1806"/>
    <dbReference type="eggNOG" id="COG4856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053150_0_0_12"/>
    <dbReference type="OMA" id="TEFSAYI"/>
    <dbReference type="OrthoDB" id="992089at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012505">
        <property type="entry name" value="YbbR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07949">
        <property type="entry name" value="YbbR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="319" mass="35364" checksum="3AD7942B2626B28A" modified="2004-07-05" version="1">MKIRKIFDRLAENWLAKVISFALAIVLVQLYKGSLLEKKYFYAPLVIENSGDLVPAVNIPRLVKVSVWGDSTVIAPIMEEHITAYMDLSAISSPGEYRIPIQAKLKGLASNISDFEVEVEPSDITLTLEESLSKRVNVRLNLGGVPAENYEVYERDVDPATVEIKGPHSVVSQIEEMLTNSVQIDNRKTGFSGYVEVFASNPLVSVIGTSRIAYSIKIREIVSLQTYEEIALYFENLNEKFEVVTDSVLGNITVKGTKSNIASWTLPENVLRVNCSNITKPGVYSLPVQAVIPGKLSLIDANPKNIQFEVKIKEAKTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LF8</accession>
    <name>Q73LF8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972509.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679604.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1906"/>
    <dbReference type="EnsemblBacteria" id="AAS12420">
        <property type="protein sequence ID" value="AAS12420"/>
        <property type="gene ID" value="TDE_1906"/>
    </dbReference>
    <dbReference type="GeneID" id="2740404"/>
    <dbReference type="KEGG" id="tde:TDE_1906"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1804"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071023_2_0_12"/>
    <dbReference type="OMA" id="ETYIIFI"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="254" mass="29857" checksum="7E1E386D0E5B0B91" modified="2004-07-05" version="1">MLKRFEDLTLQDDFMFCKVMQNPDLCKKLIEMILSDTIGQISYISIQHNINTYEQAKSVRFDVLVQTENGKFYDVEIQVSDEKNIPKRMRFYQAAIDISFLDKGNSYNDLNDSFIIFICLFDVIGKNRPVYTFENICFEDKNISLQDGTKKIIINTEAFYNTKNKELKEFLEYLKTGKAKNEFTREIEAMIQTIKKNEQARQEYRLMSTFEMDARYKGAYDKSIETAKLMKKRGYPISEILLMTGLPEAEIEKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LG6</accession>
    <name>SECA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="1">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secA</name>
        <name type="ordered locus">TDE_1898</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.</text>
            <dbReference type="EC" id="7.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">May bind 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972501.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679596.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73LG6"/>
    <dbReference type="SMR" id="Q73LG6"/>
    <dbReference type="STRING" id="243275.TDE_1898"/>
    <dbReference type="EnsemblBacteria" id="AAS12412">
        <property type="protein sequence ID" value="AAS12412"/>
        <property type="gene ID" value="TDE_1898"/>
    </dbReference>
    <dbReference type="GeneID" id="2739127"/>
    <dbReference type="KEGG" id="tde:TDE_1898"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1797"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_12"/>
    <dbReference type="OMA" id="MVHYDVQ"/>
    <dbReference type="OrthoDB" id="212453at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008564">
        <property type="term" value="F:protein-exporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000321029" description="Protein translocase subunit SecA">
        <location>
            <begin position="1"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="850"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="854"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="906"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="908"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="917"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="918"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="922" mass="105692" checksum="E32E45701DAF4A7E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LH8</accession>
    <name>Q73LH8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1885"/>
    <dbReference type="EnsemblBacteria" id="AAS12399">
        <property type="protein sequence ID" value="AAS12399"/>
        <property type="gene ID" value="TDE_1885"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1885"/>
    <dbReference type="HOGENOM" id="CLU_2774746_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="69" mass="7921" checksum="66DF7EC7035E2422" modified="2004-07-05" version="1">MRGETYEGVTGSGIEICAKHAEPTIIHKNKNAITFFIFTSAQIPYIFIKLPNNFIIKYINPQDMHFHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LQ1</accession>
    <name>Q73LQ1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972415.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957060.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1811"/>
    <dbReference type="EnsemblBacteria" id="AAS12326">
        <property type="protein sequence ID" value="AAS12326"/>
        <property type="gene ID" value="TDE_1811"/>
    </dbReference>
    <dbReference type="GeneID" id="2739241"/>
    <dbReference type="KEGG" id="tde:TDE_1811"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1721"/>
    <dbReference type="eggNOG" id="ENOG5032RV5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082970_0_0_12"/>
    <dbReference type="OrthoDB" id="783096at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="1">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="236" mass="27361" checksum="65A3EEC2E190A793" modified="2004-07-05" version="1">MINWKEYESGIYFLYNKLINKGYPNLKIEKNQEIKGKSGLLHEIDVVISFDLLNEKRLMLIECKNFSKRKVEKSDIMILHSKVNDINSSFGIIVTTKGFQTGAKEYADYFGITTLVISELSIIIKSSKQTLKVVLPDEYDLPKPFYTIMYIKNGENTGSYKMIESQEKHAFMLFLSKKEASKWLQKDEKIFPVTLEHLEIICRYSEKFNKGIIVFFGYAGEGISLSSNQLRELYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LQ3</accession>
    <name>Q73LQ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972413.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12324">
        <property type="protein sequence ID" value="AAS12324"/>
        <property type="gene ID" value="TDE_1809"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1809"/>
    <dbReference type="HOGENOM" id="CLU_3391912_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="32" mass="3849" checksum="AA9F67FC6232C504" modified="2004-07-05" version="1">MDMKIIKLYIKILSFLFIKYCNKKLNSVKLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LU5</accession>
    <name>Q73LU5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transgly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972371.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679519.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1767"/>
    <dbReference type="EnsemblBacteria" id="AAS12282">
        <property type="protein sequence ID" value="AAS12282"/>
        <property type="gene ID" value="TDE_1767"/>
    </dbReference>
    <dbReference type="GeneID" id="2740612"/>
    <dbReference type="KEGG" id="tde:TDE_1767"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1687"/>
    <dbReference type="eggNOG" id="ENOG5032INI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112491_0_0_12"/>
    <dbReference type="OrthoDB" id="1639406at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="2">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="213" mass="25211" checksum="0C03FB229FE61751" modified="2004-07-05" version="1">MELALSKKNIRSLVIKIFLYLLLFMLLCCLFLYIFLNIYINKKGIKIKYENIKNETTVELTEKQIEIMSYIYTNNKDPKFKKLPLIMDFVSSKNKMAYIMATFYFAKIDERNKKITTMDRRIIIFGTMRNIEKNIDYKDCYNYVISNAHFGNGIIGLADASKCYFDKDYNCLSNEEFIKLILATINPIKYNIEIGNKRLIEEKVNEISKRINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LY2</accession>
    <name>Q73LY2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl hydrolase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972334.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679450.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1730"/>
    <dbReference type="CAZy" id="GH2">
        <property type="family name" value="Glycoside Hydrolase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12245">
        <property type="protein sequence ID" value="AAS12245"/>
        <property type="gene ID" value="TDE_1730"/>
    </dbReference>
    <dbReference type="GeneID" id="2739188"/>
    <dbReference type="KEGG" id="tde:TDE_1730"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1654"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009935_3_1_12"/>
    <dbReference type="OMA" id="VERYACS"/>
    <dbReference type="OrthoDB" id="1832114at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="79"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="192"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="298"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="600" mass="68709" checksum="A93BDA58F117AFDC" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LZ1</accession>
    <name>Q73LZ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972325.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679438.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1721"/>
    <dbReference type="EnsemblBacteria" id="AAS12236">
        <property type="protein sequence ID" value="AAS12236"/>
        <property type="gene ID" value="TDE_1721"/>
    </dbReference>
    <dbReference type="GeneID" id="2739179"/>
    <dbReference type="KEGG" id="tde:TDE_1721"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1645"/>
    <dbReference type="eggNOG" id="COG1533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015525_2_2_12"/>
    <dbReference type="OMA" id="NELPYER"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031012">
        <property type="entry name" value="rSAM_mob_pairB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04470">
        <property type="entry name" value="rSAM_mob_pairB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="23"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="302" mass="34554" checksum="3B63B411A4F7F2A4" modified="2004-07-05" version="1">MAEVIDGILIGEVETKNIMTKSSLPVGGYSVNPYVGCTHACKYCYASFMKRFTGHKEEWGTFLDVKHWPEIKNPKKYAGQRVVIGSVTDGYNPQEGQFENTRKLLEQLIGSDADILICTKSDLVVRDIDLLKKLGRVTVSWSINTLDENFKNDMDSASSIERRIASMKQVYDAGIRTVCFVSPVFPGITDFEAIFERVKGQCDLFWLENLNLRGGFKKTIMDYIAGKYPDLVPLYDEIYNKHNRSYFEALEVKAEEMAKKYDCPFVDNEMPYGRVPQGHPVIVDYFYHEEIRGTENTGKRNR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LZ4</accession>
    <name>GUAA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="1">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">guaA</name>
        <name type="ordered locus">TDE_1718</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972322.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73LZ4"/>
    <dbReference type="SMR" id="Q73LZ4"/>
    <dbReference type="STRING" id="243275.TDE_1718"/>
    <dbReference type="MEROPS" id="C26.957"/>
    <dbReference type="EnsemblBacteria" id="AAS12233">
        <property type="protein sequence ID" value="AAS12233"/>
        <property type="gene ID" value="TDE_1718"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1718"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1643"/>
    <dbReference type="eggNOG" id="COG0519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_12"/>
    <dbReference type="OMA" id="KRKIIGH"/>
    <dbReference type="OrthoDB" id="504464at2"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0332">GMP biosynthesis</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000140200" description="GMP synthase [glutamine-hydrolyzing]">
        <location>
            <begin position="1"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="GMPS ATP-PPase" evidence="1">
        <location>
            <begin position="209"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="236"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <sequence length="523" mass="58365" checksum="8914005E11E6F41C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LZ5</accession>
    <name>Q73LZ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972321.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679430.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1717"/>
    <dbReference type="EnsemblBacteria" id="AAS12232">
        <property type="protein sequence ID" value="AAS12232"/>
        <property type="gene ID" value="TDE_1717"/>
    </dbReference>
    <dbReference type="GeneID" id="2740889"/>
    <dbReference type="KEGG" id="tde:TDE_1717"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1642"/>
    <dbReference type="eggNOG" id="ENOG5031CVB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111162_0_0_12"/>
    <dbReference type="OrthoDB" id="2066165at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044384">
        <property type="term" value="C:host outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000758">
        <property type="entry name" value="Enterovir_OMP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00695">
        <property type="entry name" value="ENT_VIR_OMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284938" evidence="1">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="216" mass="23191" checksum="ED8816C159E0E3B8" modified="2004-07-05" version="1">MKKLIFVFLLVALLATPLAALDFSAGGDFSFAHMLNIVKVEDVKGTTSVNFLGVNGFFDAEYVRAGLGVNFLVGGITAKLENAGPLSGTTKDNKTSLINLRLSVLGKYPFTIAKIVKLYPLAGMEVDFNVSAKYDGKNAKEHLSDDEKKDLNHYYLVLGVGADITVTGNLFVTPKATFGFDLRQNSTAKAAKKAGANIKGGHQMKIEFGLGVGYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M06</accession>
    <name>Q73M06_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972309.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679413.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1705"/>
    <dbReference type="EnsemblBacteria" id="AAS12220">
        <property type="protein sequence ID" value="AAS12220"/>
        <property type="gene ID" value="TDE_1705"/>
    </dbReference>
    <dbReference type="GeneID" id="2740877"/>
    <dbReference type="KEGG" id="tde:TDE_1705"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1630"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083338_0_0_12"/>
    <dbReference type="OrthoDB" id="1879188at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="312" mass="35603" checksum="517952190C980FB4" modified="2004-07-05" version="1">MLLKTKIDLLKKSLFLCLFLIMGSFAVGQNFDLAGFGYTDGPPVAYFIKFQKGNKIEISWYNAKEQEVKKVYTYKKKYIGRFPLFELDADMPDDLYANLDPKSKEYLGNKFMLLTGLAKKAWGENEDAVIGLGILPASKGKKASGFFTRFPTGGTGETPYFYYENVSSHLVEKSKEGKREYKIENLCDMREDTPWVEGVAGWGIGESFVIKTWKSSDDKYILLMNGYISASNPKLYDENGRIKKIMVEGVTSGKKKEFTVKDTPHPQTVDISFLPEQEDVKITILDVYKGTKYEDTAIHFMILWRTEVIPYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M16</accession>
    <name>Q73M16_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoA-substrate-specific enzyme activase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972299.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679398.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1695"/>
    <dbReference type="EnsemblBacteria" id="AAS12210">
        <property type="protein sequence ID" value="AAS12210"/>
        <property type="gene ID" value="TDE_1695"/>
    </dbReference>
    <dbReference type="GeneID" id="2740867"/>
    <dbReference type="KEGG" id="tde:TDE_1695"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1621"/>
    <dbReference type="eggNOG" id="COG1924">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002393_1_0_12"/>
    <dbReference type="OMA" id="DNHFNCP"/>
    <dbReference type="OrthoDB" id="8032at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018709">
        <property type="entry name" value="CoA_activase_DUF2229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09989">
        <property type="entry name" value="DUF2229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="2">
        <location>
            <begin position="10"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="BcrAD_BadFG" evidence="2">
        <location>
            <begin position="377"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2229" evidence="3">
        <location>
            <begin position="758"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1500" mass="166486" checksum="66893F5822D9F52E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MD6</accession>
    <name>Q73MD6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972178.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679242.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12089">
        <property type="protein sequence ID" value="AAS12089"/>
        <property type="gene ID" value="TDE_1572"/>
    </dbReference>
    <dbReference type="GeneID" id="2739322"/>
    <dbReference type="KEGG" id="tde:TDE_1572"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1502"/>
    <dbReference type="eggNOG" id="ENOG5030VD2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1433898_0_0_12"/>
    <dbReference type="OrthoDB" id="1455764at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="189" mass="22377" checksum="2E5C2044FE4603F8" modified="2004-07-05" version="1">MKNFFLILFFILIIMEVNAMFSGIIFWDISIKDSDIKKLDKNDIVMCLKEKINIIYAIEESKILSYFYDKHCIEVNCDVNLEDLKANMKGFNDLLFSFVIDDMIVFTGINRIGRPPLAAKNMYDDEFIKLFEVRYINKYYLVFSNTPYSVLYSIKSVANSDNGKIKKEYAILYNFFIKRKKLRMNFSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MF4</accession>
    <name>Q73MF4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972160.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679214.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1554"/>
    <dbReference type="EnsemblBacteria" id="AAS12071">
        <property type="protein sequence ID" value="AAS12071"/>
        <property type="gene ID" value="TDE_1554"/>
    </dbReference>
    <dbReference type="GeneID" id="2739304"/>
    <dbReference type="KEGG" id="tde:TDE_1554"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1490"/>
    <dbReference type="eggNOG" id="ENOG5032FYY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_821199_0_0_12"/>
    <dbReference type="OrthoDB" id="1104495at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="338" mass="39500" checksum="24A3871AADA3490A" modified="2004-07-05" version="1">MNRVKSLLLAIIIIFIRLEAEQVYIAPLLSVDEGEESYETDTKLQDDICESIEEQKEFLGVEIIKTRKKIKQVRSSYDALKLCREEKIKYLIYGWIKKSEYTYEGELRIFDGEGRKNIFTVYEKDGIENYEKFIKNISKKVLDSLHEIFYIPKQEEVEKYSRINVGTDIWYWTFMNKALVKYMSGTIGIGGSFEIIPDDSVFFIKTYPVYFSVGLSLDYRLGVNRKEAIKSYLNNINAVGYTNMYINFYDIHRVYAKAGVLYSLDIVSYQDKYSDSKVNTSGAVGIITGIGYKYAVTEKIKIIFANEFEFVFYKNVMSKYLGKVGVEFEVFKKEYKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MF8</accession>
    <name>Q73MF8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="9">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="9">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pfp</name>
        <name evidence="11" type="ordered locus">TDE_1550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="9"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972156.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956991.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1550"/>
    <dbReference type="EnsemblBacteria" id="AAS12067">
        <property type="protein sequence ID" value="AAS12067"/>
        <property type="gene ID" value="TDE_1550"/>
    </dbReference>
    <dbReference type="GeneID" id="2740912"/>
    <dbReference type="KEGG" id="tde:TDE_1550"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1486"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022288_2_0_12"/>
    <dbReference type="OMA" id="SAKKYWH"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01980">
        <property type="entry name" value="Phosphofructokinase_II_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011183">
        <property type="entry name" value="PfpB_PPi_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005677">
        <property type="entry name" value="PPi_PFK_PfpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02477">
        <property type="entry name" value="PFKA_PPi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="10">
        <location>
            <begin position="74"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="203"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with dimeric partner" evidence="9">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="250"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="425"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="9">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="9">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS12067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="560" mass="63141" checksum="D5D9695D26343B17" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MJ0</accession>
    <name>Q73MJ0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1518</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679166.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12035">
        <property type="protein sequence ID" value="AAS12035"/>
        <property type="gene ID" value="TDE_1518"/>
    </dbReference>
    <dbReference type="GeneID" id="2739724"/>
    <dbReference type="KEGG" id="tde:TDE_1518"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1457"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055576_0_0_12"/>
    <dbReference type="OMA" id="LYGHEFP"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="301"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="403" mass="45061" checksum="11C58918609152F7" modified="2004-07-05" version="1">MENLQTKKLTVFELAKLNIKRKPFRTASLIILTAVLAFSLFAGSFLVKSLRGGMLSLSNRLGADIIVVPQGYDSKIESALLRGEPNSFYFDTEVVERVKKIEGVELASPQLFIATLSAGCCSFPLQIIGIDFDSDFNVKPWLKKQIKLPLLDNQIVAGSNISGDYNSQVKFFNQPFVIAGRLTKTGMGFDNSIFMTIENARKLAKEYERIMQHPVAKNENLISSVMVKINPRYDAGEVAKKIREEFKGEEIYPLISKRMMTNISSSISSLNIYVYILIAILWILSFIVLAVSFSSIFNERKEEFGMLRIIGSTKKKLFELAVLESLMISMSGAIIGTVLSCLIMFLFNQAIVTGMKMPFLNPSFLWTFVCFLLTFALISVIGPLAALKTMYSFTKEEPALSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ML9</accession>
    <name>Q73ML9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972095.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671248.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1489"/>
    <dbReference type="EnsemblBacteria" id="AAS12006">
        <property type="protein sequence ID" value="AAS12006"/>
        <property type="gene ID" value="TDE_1489"/>
    </dbReference>
    <dbReference type="GeneID" id="2739890"/>
    <dbReference type="KEGG" id="tde:TDE_1489"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1428"/>
    <dbReference type="eggNOG" id="ENOG5032MMM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_983324_0_0_12"/>
    <dbReference type="OrthoDB" id="1381454at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284601" evidence="1">
        <location>
            <begin position="25"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="280" mass="30755" checksum="B176FA7BCC75896F" modified="2004-07-05" version="1">MKKILSILVFFTCVSILFSLDVTASITVGNTPFNSNGYTGKIPDFGFKLILNEDLGKNVNGKLAIERHLGIGNIIWGRIAYTTDMINIAIGPTLSVFNAGFDNKNVSTIFQPGLGTSLSFKLPIGFFTSLDTNFSIPLASVKTKNVYLQNGHFDLGWRFPNIIASIKLSQKNKSIVDNPDETHISISDIGFYTVSYSKPSGIRIPLNIIYRVNHFQKTGSLNEKIADIVLETGISHSASSDIEWFVNFGASVFSFSLTNAGSRVKKFFFNAEAGIVLNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MN4</accession>
    <name>Q73MN4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1474</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972080.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1474"/>
    <dbReference type="EnsemblBacteria" id="AAS11991">
        <property type="protein sequence ID" value="AAS11991"/>
        <property type="gene ID" value="TDE_1474"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1474"/>
    <dbReference type="HOGENOM" id="CLU_3405975_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3471" checksum="64E1984C61C4810E" modified="2004-07-05" version="1">MLGFFNNKADLVKADTERDNRMSSLKIKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MT4</accession>
    <name>Q73MT4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FdtA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972029.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679036.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1423"/>
    <dbReference type="EnsemblBacteria" id="AAS11940">
        <property type="protein sequence ID" value="AAS11940"/>
        <property type="gene ID" value="TDE_1423"/>
    </dbReference>
    <dbReference type="GeneID" id="2739700"/>
    <dbReference type="KEGG" id="tde:TDE_1423"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1364"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2037032_0_0_12"/>
    <dbReference type="OrthoDB" id="2070545at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008894">
        <property type="entry name" value="QdtA_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05523">
        <property type="entry name" value="FdtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FdtA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="115" mass="13043" checksum="8BBD72E80B6B6460" modified="2004-07-05" version="1">MNIIKLPKITDTRGSLSYLESNRHVPFIIASVKLLPVKIETEKYLFRNNNADFLLLPLCGIFKLAEKNAETEYIADEADKGIHVSKKDFSISGFTENTVILILCSKPDFNVRLEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-19" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N16</accession>
    <name>RL25_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplY</name>
        <name evidence="1" type="synonym">ctc</name>
        <name type="ordered locus">TDE_1340</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971946.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678895.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73N16"/>
    <dbReference type="SMR" id="Q73N16"/>
    <dbReference type="STRING" id="243275.TDE_1340"/>
    <dbReference type="EnsemblBacteria" id="AAS11857">
        <property type="protein sequence ID" value="AAS11857"/>
        <property type="gene ID" value="TDE_1340"/>
    </dbReference>
    <dbReference type="GeneID" id="2741074"/>
    <dbReference type="KEGG" id="tde:TDE_1340"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1288"/>
    <dbReference type="eggNOG" id="COG1825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075939_2_1_12"/>
    <dbReference type="OMA" id="HVDFYEV"/>
    <dbReference type="OrthoDB" id="1673077at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000181611" description="50S ribosomal protein L25">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="211" mass="23243" checksum="F939BCB507FAC6CE" modified="2004-07-05" version="1">MEQRLLNANERSTYGKNAAVKMRKAGRIPAVMYDRHGKSVPIDVDEREFMKLFKLVTESTIVTLNAAGKDYEVFIKDFQHDIVSDKIKHIDFYEVERGKTLRTKVKIRLEGSPEGVRHGGILETGITELELECLPKDLPARIIVDVSALDVNQSLHVRDIKLPEAVTVLTSDDITVAAIKFAAAESTTPAATEGEETEAAAAAPEPAAEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N24</accession>
    <name>Q73N24_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein HflK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">HflC and HflK could encode or regulate a protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">HflC and HflK may interact to form a multimeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the band 7/mec-2 family. HflK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971938.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678884.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1332"/>
    <dbReference type="EnsemblBacteria" id="AAS11849">
        <property type="protein sequence ID" value="AAS11849"/>
        <property type="gene ID" value="TDE_1332"/>
    </dbReference>
    <dbReference type="GeneID" id="2741066"/>
    <dbReference type="KEGG" id="tde:TDE_1332"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1280"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039173_0_1_12"/>
    <dbReference type="OMA" id="WNEPGGN"/>
    <dbReference type="OrthoDB" id="577287at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03404">
        <property type="entry name" value="SPFH_HflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010201">
        <property type="entry name" value="HflK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF2">
        <property type="entry name" value="PTHR43327:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01933">
        <property type="entry name" value="hflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="6">
        <location>
            <begin position="30"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="318" mass="35830" checksum="13D882B7E0224E89" modified="2004-07-05" version="1">MKQKKVDPSKMLGALRTVIILVVIALIAFSGIKVIPTTDNGVVTRFGKYTNTLSPGLNFVIPFVDRVYKVPVKTVQKEEFGFRTSKAGERSEYQNSMLNESSMLTGDLNIINVEWVIQYKIVDPKAWLFNVDEDQRNKTVRDVSKSVVNSLVGDRAIMDIISLDRDSIAVLAQEKMNEKYKQIGLGISVSSVQLQNIVPPHEVQAAFEDVNIAIQDMNRLINEGKEAYNKEIPKAKGEAQKMIEEARGYASERINKAKGDVARFNAVYSEYVKAPDITRRRLYLETLDAIFKNNENVTLIDKNLKNFLPLKELNKGGN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N26</accession>
    <name>NRDR_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nrdR</name>
        <name type="ordered locus">TDE_1330</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971936.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678882.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73N26"/>
    <dbReference type="SMR" id="Q73N26"/>
    <dbReference type="STRING" id="243275.TDE_1330"/>
    <dbReference type="PRIDE" id="Q73N26"/>
    <dbReference type="EnsemblBacteria" id="AAS11847">
        <property type="protein sequence ID" value="AAS11847"/>
        <property type="gene ID" value="TDE_1330"/>
    </dbReference>
    <dbReference type="GeneID" id="2741064"/>
    <dbReference type="KEGG" id="tde:TDE_1330"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1278"/>
    <dbReference type="eggNOG" id="COG1327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108412_0_0_12"/>
    <dbReference type="OMA" id="YRFTTYE"/>
    <dbReference type="OrthoDB" id="1551627at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000182374" description="Transcriptional repressor NrdR">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-cone" evidence="1">
        <location>
            <begin position="49"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <sequence length="151" mass="17621" checksum="A9AF621FCDF0F2E8" modified="2004-07-05" version="1">MRCPHCGNCDDKVMESRTLAQGDCIRRRRECLACGYRFTSYEHIEEKPFMVIKKDGRREPFDRKKLEKGIERALEKRPVSLNSIENIVTEIEDQAVLNSGLNKEIETTVLGEMVLSHLYSIDKVAYIRFASVYKQFSNLDEFVNEVKKVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N75</accession>
    <name>Q73N75_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971887.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678782.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1280"/>
    <dbReference type="EnsemblBacteria" id="AAS11798">
        <property type="protein sequence ID" value="AAS11798"/>
        <property type="gene ID" value="TDE_1280"/>
    </dbReference>
    <dbReference type="GeneID" id="2740573"/>
    <dbReference type="KEGG" id="tde:TDE_1280"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1230"/>
    <dbReference type="eggNOG" id="COG4912">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095329_0_0_12"/>
    <dbReference type="OMA" id="DNWATCD"/>
    <dbReference type="OrthoDB" id="1933111at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014825">
        <property type="entry name" value="DNA_alkylation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08713">
        <property type="entry name" value="DNA_alkylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="233" mass="28102" checksum="3B27BBE550C11C7F" modified="2004-07-05" version="1">MKTKQTLIQTKLFPFEDKKYKNFNKKLIPNIDENTMIGIRTPVLRKFAKEFFKTEPEQVSDFMKDVPHKYFEENNLHCFFIENIKDFNEALKETEKFLPYIDNWATCDSFSPKIFKKNHEEIYKKILVWLKSKHTYTVRYAIGLLLSNYLDEHFRPEMLEIVSKIRSDEYYINMMIAWYFSFALIKQYKTALPYIKNKKLDTFTHNKAIQKAIESYRIPKEVKELLRGMKVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NC8</accession>
    <name>Q73NC8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971834.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1227"/>
    <dbReference type="EnsemblBacteria" id="AAS11745">
        <property type="protein sequence ID" value="AAS11745"/>
        <property type="gene ID" value="TDE_1227"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1227"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1182"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049724_0_0_12"/>
    <dbReference type="OMA" id="NWESNDI"/>
    <dbReference type="OrthoDB" id="302683at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="444" mass="50293" checksum="6429F584DCF13580" modified="2004-07-05" version="1">MTKLYKTSKIRFMRLSIYSSFFMKKFLCIFCFFLSVLLCFADFAFDLNLQPYKNAEFFADGLKVESKLISSDKTLGHLSFTLNDTTTSLVIKKEGFRTHSLDLTSIENKKAFVVLSPIDSKYDVVKVFPTGRKPKSVTFVNDKAVAVALLDGSGFDLIDIETGETKRISPPKEYAEKFGFVESLVLKHKNELWVSQMPTASIHIFDLTSFEYKRTINSTGTWSKVMAYNAGLDKVYLSNWTSQDISVIDPSSYKEEKKIKTKAVPRGMAFSQDGKFIYCAQFEDSAGNSQCKLIKKSLADYKTVYEGGVKGAKRHIVTDYERKLIYVSDMRNDIVEAYSTDKDELVASIKVFFNPNTIQLSPDKSLLYVSCRGPNNPDKGYLYKGYVFGRLDIIDTKTFTRIESIEAGNQPTGLDVSPDGKKIVLSDFLDNRIRVYELKSSLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NF1</accession>
    <name>Q73NF1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell division protein FtsQ, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_1202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971809.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668441.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1202"/>
    <dbReference type="EnsemblBacteria" id="AAS11720">
        <property type="protein sequence ID" value="AAS11720"/>
        <property type="gene ID" value="TDE_1202"/>
    </dbReference>
    <dbReference type="GeneID" id="2741163"/>
    <dbReference type="KEGG" id="tde:TDE_1202"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1157"/>
    <dbReference type="eggNOG" id="COG1589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069614_0_0_12"/>
    <dbReference type="OMA" id="YYFIASD"/>
    <dbReference type="OrthoDB" id="1005603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="8">
        <location>
            <begin position="62"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="285" mass="32007" checksum="0E055C17615A2CDB" modified="2004-07-05" version="1">MADILYTWKKNEYLNDAYVKEKVINDNKSSKLKSAVVRFLIISFVLLLLGEIIYYAIILPYSSIAAVNISGCSDLSSIEVKKLAGIESNTKWLSIDSSEISKKLVSYPGIASVTVEKKFPDKVSIKIVERKAVALAFTEVEGRTVPMEIDGYGVVFRIGSPIIKSNLPIITGLTFKSPREGMQVNEKLSQLFVQLDILQKKHPVLLNEISEIKIQPKKYGGYDLILYPVKSRLSVITNKFLTEESLQYMILILDVVKDINLEKNIIGIDLRGANAVYIKREAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NS3</accession>
    <name>Q73NS3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein/PTS system, IIA component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971687.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1079"/>
    <dbReference type="EnsemblBacteria" id="AAS11568">
        <property type="protein sequence ID" value="AAS11568"/>
        <property type="gene ID" value="TDE_1079"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1079"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1039"/>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072531_5_0_12"/>
    <dbReference type="OMA" id="FDAPDEQ"/>
    <dbReference type="OrthoDB" id="1770263at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="53"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="201" mass="22445" checksum="0D1AB7B5A51FA39B" modified="2004-07-05" version="1">MRVSERTVYEWAQKGEIPAGKIGTVWRFKKDDIESWVDERLASSKTSVSKQHKIVTENFLSPDRVVLLDYASKHDVLVMMSEVLAKAPQVKNSAELLDAILKREALMSTAVGRGIAIPHVRLSSVTDLVMAVGISKRDILDFDAVDGNPVRLVFMIAAANNQHDYYLQTISHFSAKLRNEELKSSLLNSTDPAEVYALLCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NU6</accession>
    <name>Q73NU6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971664.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11545">
        <property type="protein sequence ID" value="AAS11545"/>
        <property type="gene ID" value="TDE_1056"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1056"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1018"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_2_2_12"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="201" mass="22341" checksum="B539EDC02D5A8920" modified="2004-07-05" version="1">MQAEGKADTECVYRKKDDHTVVLKDATATADCDAAYADMSKKGFRLPTEAEWEYAARWQGSDKTNAAQYGEVWLTKLNSASGAKDKWDTAETGEVAWYRGNSGNKTHPVGKKRANALGLYDMSGNVWEWCFDWYNNPASNDDAYKQGGIVTDPQGAASGSYRVLRGGSWYDSAKNCTVGFRFNRDPGYGNLDIGFRLAWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NU8</accession>
    <name>Q73NU8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1054</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971662.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682361.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1054"/>
    <dbReference type="EnsemblBacteria" id="AAS11543">
        <property type="protein sequence ID" value="AAS11543"/>
        <property type="gene ID" value="TDE_1054"/>
    </dbReference>
    <dbReference type="GeneID" id="2741328"/>
    <dbReference type="KEGG" id="tde:TDE_1054"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1014"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_12"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="308"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="406"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="692" mass="76590" checksum="3E2E947B00F1940F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NX5</accession>
    <name>RNC_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease 3</fullName>
            <ecNumber evidence="1">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribonuclease III</fullName>
            <shortName evidence="1">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnc</name>
        <name type="ordered locus">TDE_1027</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971635.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670498.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NX5"/>
    <dbReference type="SMR" id="Q73NX5"/>
    <dbReference type="STRING" id="243275.TDE_1027"/>
    <dbReference type="EnsemblBacteria" id="AAS11516">
        <property type="protein sequence ID" value="AAS11516"/>
        <property type="gene ID" value="TDE_1027"/>
    </dbReference>
    <dbReference type="GeneID" id="2741505"/>
    <dbReference type="KEGG" id="tde:TDE_1027"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.989"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_3_12"/>
    <dbReference type="OMA" id="LTHKSCK"/>
    <dbReference type="OrthoDB" id="1890943at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000228598" description="Ribonuclease 3">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="16"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="1">
        <location>
            <begin position="171"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <sequence length="246" mass="27604" checksum="F242DA11ED988D43" modified="2004-07-05" version="1">MFPIKSGLEPKRKQELLEFQKQAGLKFKDLRLLDLAFHHRSFSNEHNNFHANNERLEFLGDSVLGLVAASYLYKSFEDRPEGELAKIKASAVSEDALSKTASKLNISNYLVLGRGEEMSGGREKKAILADALEAVIGAYYIDSGFKAAQKFVLRLLESTIHSVLEKKFISDYKSLLQELVQKKFKTVPKYELKKASGPDHDRTFWFSVSINGKVYGPLSGKTKKEAEQSVAKVAYENLCSESTVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P06</accession>
    <name>Q73P06_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971603.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0994"/>
    <dbReference type="EnsemblBacteria" id="AAS11484">
        <property type="protein sequence ID" value="AAS11484"/>
        <property type="gene ID" value="TDE_0994"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0994"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.956"/>
    <dbReference type="eggNOG" id="ENOG50346PZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028188_0_0_12"/>
    <dbReference type="OMA" id="ETERGIH"/>
    <dbReference type="OrthoDB" id="872822at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="609" mass="68392" checksum="CE8492824CF9C16C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P54</accession>
    <name>Q73P54_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971555.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682244.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0945"/>
    <dbReference type="EnsemblBacteria" id="AAS11436">
        <property type="protein sequence ID" value="AAS11436"/>
        <property type="gene ID" value="TDE_0945"/>
    </dbReference>
    <dbReference type="GeneID" id="2740978"/>
    <dbReference type="KEGG" id="tde:TDE_0945"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.910"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_1_0_12"/>
    <dbReference type="OMA" id="CNAYSEM"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="108"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="370" mass="40046" checksum="7D64E38FA6661CF1" modified="2004-07-05" version="1">MIKLNLNKSSAASSGRLCALKRAAALIIAALVALIIAALVAPIALFGMTGCPNNAGGGGSPPNVGSVEDTGDGFIKITPPANGIVGVAPNYALPGSEAWWKGVFIKDRKVKLSPYKLGKTEVTYKLWKEVYDWATGHGYTFANPGVKGKDGSGTDDEPVTTISWRDCIVWCNAYTQMKAEGKADTECVYRKKDDHTVVLKDATATADCDAAYAEMGKKGFRLPTEAEWEYAARRQGSDTTNAVQYSDVYLTKLNSASGAKADWNDAAETGAVAWYSGNSGGKTHPVGERRANALGLHDMSGNVWEWCFDWYDDIEANTVTDPQGGASGSYRVLRGGSWYFYAHYCTVGVRGYYSPDYWSFYLGFRLACRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P59</accession>
    <name>Q73P59_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971550.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670335.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0940"/>
    <dbReference type="EnsemblBacteria" id="AAS11431">
        <property type="protein sequence ID" value="AAS11431"/>
        <property type="gene ID" value="TDE_0940"/>
    </dbReference>
    <dbReference type="GeneID" id="2740973"/>
    <dbReference type="KEGG" id="tde:TDE_0940"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.906"/>
    <dbReference type="eggNOG" id="ENOG5032GS1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1748858_0_0_12"/>
    <dbReference type="OrthoDB" id="1978733at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284987" evidence="1">
        <location>
            <begin position="20"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="139" mass="16007" checksum="F81811B1BD38EB64" modified="2004-07-05" version="1">MKKLLVFVVLMLCFLSCKTKQIQPKIEGAYIQLTDKAQISFKDLPCTVFFSDGTEEKHLTNEDGKVVVQVIEGRIITKVVYDFSDYKRPKGKLLAKEEFSIIRKLKIKPKSLIQEFNIDLEPVKGMQLIIILNVFNIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P72</accession>
    <name>Q73P72_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphonate ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971537.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682230.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0927"/>
    <dbReference type="EnsemblBacteria" id="AAS11418">
        <property type="protein sequence ID" value="AAS11418"/>
        <property type="gene ID" value="TDE_0927"/>
    </dbReference>
    <dbReference type="GeneID" id="2740392"/>
    <dbReference type="KEGG" id="tde:TDE_0927"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.895"/>
    <dbReference type="eggNOG" id="COG3639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064254_1_2_12"/>
    <dbReference type="OMA" id="RFAIIGR"/>
    <dbReference type="OrthoDB" id="1209768at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015716">
        <property type="term" value="P:organic phosphonate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017797">
        <property type="entry name" value="Phosphnate-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30043:SF1">
        <property type="entry name" value="PTHR30043:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="98"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="289" mass="32686" checksum="B97C90D7696B3D09" modified="2004-07-05" version="1">MKFDLKIYSEDKKKKRHYHKKETSYSWEKKQFFFAKKKLKAIIILLSLILIYYFASNITGFKDLKAIFKFPLAIAWLIKNFKPDNESLKHIPIIIKTLGETCVIAASATTAAAFFALILALLGSQTTGINKPFQIILTMTASFLRNIPLVAWAMLLLFSFKQNNFTGFLALFIITLGHLVRAFKEMIEETSEESFTALRAAGVPYFPALFNAVFPSIAPGLVSWLLYTVETNVRDSALIGILTGTGIGFLFNLYFKSFRYNSAGLIILCLVIIVLLIDILSNKIRRILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P74</accession>
    <name>Q73P74_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase T</fullName>
            <ecNumber evidence="5">3.4.11.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aminotripeptidase</fullName>
            <shortName evidence="5">Tripeptidase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Tripeptide aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pepT</name>
        <name evidence="9" type="ordered locus">TDE_0925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves the N-terminal amino acid of tripeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Release of the N-terminal residue from a tripeptide.</text>
            <dbReference type="EC" id="3.4.11.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5 7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase M20B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.4" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971535.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682226.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0925"/>
    <dbReference type="MEROPS" id="M20.003"/>
    <dbReference type="EnsemblBacteria" id="AAS11416">
        <property type="protein sequence ID" value="AAS11416"/>
        <property type="gene ID" value="TDE_0925"/>
    </dbReference>
    <dbReference type="GeneID" id="2740390"/>
    <dbReference type="KEGG" id="tde:TDE_0925"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.893"/>
    <dbReference type="eggNOG" id="COG2195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053676_0_0_12"/>
    <dbReference type="OMA" id="GHNFHGK"/>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045148">
        <property type="term" value="F:tripeptide aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00550">
        <property type="entry name" value="Aminopeptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010161">
        <property type="entry name" value="Peptidase_M20B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF1">
        <property type="entry name" value="PTHR42994:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037215">
        <property type="entry name" value="Peptidase_M20B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01882">
        <property type="entry name" value="peptidase-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="M20_dimer" evidence="8">
        <location>
            <begin position="202"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037215-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="401" mass="44829" checksum="F3D5F619EFD9C80F" modified="2004-07-05" version="1">MDYLKRFQKYISMDTKSNEENECCPSTPGQLELGKYLVKELTEMGLKAEQDKHGYVYSAIPANTDKKVPAIGFIAHMDTAPDLDGKCVNPKVFVYKGGDIKLNDEYTMTVKDFPFLKELEGQEIITTDGTTLLGADDKAGITIIMGAIEYLLAHPEIKHGEIKIGFTPDEEIGRGADLFDVKNFGADFAYTVDGGPLGELEYENFNAASVKIEIQGKNVHPGSAKNMMVNSLSAARELENMLPEEQKPEYTEGYEGFIHLTSIEGSVDFTKMSYIIRDHFMESFLHKKELMKTAVDFLNKKYGNIIKMEIKDSYYNMKEKIEPHMEIIELAKKSMTDVGIEPHIVPVRGGTDGARLSFMGLPCPNLFAGGYNFHGRFELIPTKSIEKGIELVVKIAENNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P95</accession>
    <name>Q73P95_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971514.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0904"/>
    <dbReference type="EnsemblBacteria" id="AAS11395">
        <property type="protein sequence ID" value="AAS11395"/>
        <property type="gene ID" value="TDE_0904"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0904"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.875"/>
    <dbReference type="HOGENOM" id="CLU_3259293_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="42" mass="4913" checksum="DD5482C63C309332" modified="2004-07-05" version="1">MAKIDGFWLEFSSFLIQKFLLIKTFPPYRKKYVVIVSQTGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PI1</accession>
    <name>Q73PI1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0818</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971428.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682080.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0818"/>
    <dbReference type="EnsemblBacteria" id="AAS11309">
        <property type="protein sequence ID" value="AAS11309"/>
        <property type="gene ID" value="TDE_0818"/>
    </dbReference>
    <dbReference type="GeneID" id="2739560"/>
    <dbReference type="KEGG" id="tde:TDE_0818"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.790"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_12"/>
    <dbReference type="OMA" id="KHEMNIS"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="330"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="573" mass="64225" checksum="7AEF59FD72FBDBE7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PI2</accession>
    <name>Q73PI2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase-related ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971427.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682079.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0817"/>
    <dbReference type="EnsemblBacteria" id="AAS11308">
        <property type="protein sequence ID" value="AAS11308"/>
        <property type="gene ID" value="TDE_0817"/>
    </dbReference>
    <dbReference type="GeneID" id="2739559"/>
    <dbReference type="KEGG" id="tde:TDE_0817"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.789"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068864_0_0_12"/>
    <dbReference type="OMA" id="NHSGEGI"/>
    <dbReference type="OrthoDB" id="1116977at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025474">
        <property type="entry name" value="DUF4325"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14213">
        <property type="entry name" value="DUF4325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="98"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4325" evidence="2">
        <location>
            <begin position="278"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="359" mass="41254" checksum="C82742043C0CDE86" modified="2004-07-05" version="1">MKFTKEIEKTIKTFIIEQVSSHKNDIVTFTMKHFGISKPTTAKFLNQLVSEGIIEMKRKGRYPDYSLVTKKYFFVYKLKDKLEEDVILRKDILPLLSGLQENVQRIVQYCFTEMVNNVIDHSNADTMNVEVDLNALNIEIFVIDNGVGIFNKIQKDLGLEDPKHSILELAKGKFTSDPERHSGEGIFFTSRLCDEFTILSDNLFFSGHHENDWLLENPDSIPVSGTVVSMLIEKKSNLNISDIFNEYADPDKQPGFYKTRIPVKLMQYEGALLLSRSQAKRLITRFDKFLEVILDFQGVSEIGQAFADEVFRVFRNAHPDVHLKPINCVPAVQRMIAYISADYFQNVYNSDSADINRLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PM2</accession>
    <name>RL14_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplN</name>
        <name type="ordered locus">TDE_0777</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971387.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670011.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PM2"/>
    <dbReference type="SMR" id="Q73PM2"/>
    <dbReference type="STRING" id="243275.TDE_0777"/>
    <dbReference type="EnsemblBacteria" id="AAS11268">
        <property type="protein sequence ID" value="AAS11268"/>
        <property type="gene ID" value="TDE_0777"/>
    </dbReference>
    <dbReference type="GeneID" id="2740655"/>
    <dbReference type="KEGG" id="tde:TDE_0777"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.750"/>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_12"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="OrthoDB" id="1799923at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000266578" description="50S ribosomal protein L14">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <sequence length="122" mass="13494" checksum="A5FE641B843EDE4A" modified="2004-07-05" version="1">MIQVETRLNVADNSGAKLVECIKVIGGSKRRYAGIGDIIVVAVKEALPTSVIKKGTVEKAVIVRVSKEYRRPDGTYIRFDDNACVIVDDNKNPKGKRIFGPVARELRDHDFMKIVSLAPEVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PN1</accession>
    <name>RL3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplC</name>
        <name type="ordered locus">TDE_0767</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971377.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669995.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PN1"/>
    <dbReference type="SMR" id="Q73PN1"/>
    <dbReference type="STRING" id="243275.TDE_0767"/>
    <dbReference type="EnsemblBacteria" id="AAS11258">
        <property type="protein sequence ID" value="AAS11258"/>
        <property type="gene ID" value="TDE_0767"/>
    </dbReference>
    <dbReference type="GeneID" id="2740307"/>
    <dbReference type="KEGG" id="tde:TDE_0767"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.740"/>
    <dbReference type="eggNOG" id="COG0087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044142_4_1_12"/>
    <dbReference type="OMA" id="KRMAGRY"/>
    <dbReference type="OrthoDB" id="1270636at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000241431" description="50S ribosomal protein L3">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="208" mass="22643" checksum="1D330AD8B2D15004" modified="2004-07-05" version="1">MIGLIGKKIGMTQIFNEVGHLMPVTVIQVEPNTVVALKDKEKFGYSSVVLGLGELKEKHTSKPYAGQFSGDIKPLKLLKEFRDFDKEVAVGDKLGVEAFEKVSYLDITAISKGKGFQGVMKRWGYGGGRASHGSKFHREAGSTGHCTTPGRSFKNTTMPGRMGFDKVTVQNLQIVKIDPELGVIMVRGSVPGKKDATVFLKSAVKRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PT5</accession>
    <name>Q73PT5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0711</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971323.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681934.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0711"/>
    <dbReference type="TCDB" id="2.A.79.1.5">
        <property type="family name" value="the threonine/serine exporter (thre) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11204">
        <property type="protein sequence ID" value="AAS11204"/>
        <property type="gene ID" value="TDE_0711"/>
    </dbReference>
    <dbReference type="GeneID" id="2740618"/>
    <dbReference type="KEGG" id="tde:TDE_0711"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.688"/>
    <dbReference type="eggNOG" id="COG3610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117642_0_0_12"/>
    <dbReference type="OMA" id="TNESFNY"/>
    <dbReference type="OrthoDB" id="1567942at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="ThrE_2" evidence="6">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="163" mass="17920" checksum="6D17100B2DEEA520" modified="2004-07-05" version="1">MPLYIHTIASFIASFCFCFLFSVPKRNTYLSALCGSVSWTILIFFQSIGINYIFATLAGALAVGLLADLFAVLQKTPVTCFIVIGTIPLVPGFKVYKTMLFFVTDKLEKGVSEGVQAAFIAIAISVGLIISASVTRLIKALKKKTTEKKNQQPRRKHRGMLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PV8</accession>
    <name>Q73PV8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971300.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681908.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0688"/>
    <dbReference type="EnsemblBacteria" id="AAS11181">
        <property type="protein sequence ID" value="AAS11181"/>
        <property type="gene ID" value="TDE_0688"/>
    </dbReference>
    <dbReference type="GeneID" id="2740247"/>
    <dbReference type="KEGG" id="tde:TDE_0688"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.668"/>
    <dbReference type="eggNOG" id="ENOG5033UX3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543944_0_0_12"/>
    <dbReference type="OMA" id="WNIIALP"/>
    <dbReference type="OrthoDB" id="1175903at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285889" evidence="1">
        <location>
            <begin position="22"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="501" mass="58397" checksum="C9B1B31ACFFD3473" modified="2004-07-05" version="1">MYKRFFLMAALCCFFVINLYTQNTDEKLEADNPNSPAYKIESVEYSIKGFTKERPLSSKIPIDKKRIFFSREEFDAYIAELNTEFHNMRTIESYEITFDFLEPQNNITPVKLKIYVKDTWNIIALPYPSFDSNRGLQFKLKLKDFNFLGSLEPLTMDLIYNRNNEGKSSFEFGTGFALPFHINPVKFLWTTNAEISIDEDKKFGFDFGTGLSASYKLGVDWLTLAAGITQDIKVSASPSEKDYYLTNGFYTSLVFDIYKDQTLGTITWTPYFGIDGNWKFKEMTNEEKKGLNINWSHSFGMGKVNWINNFRQGFTVNIDNSYKYNTYKKGNVDVSFNLQTKGFYSFLERVGLYGRFDFFYNLFGKTSSEHTGKILRGILNKRIETDTAFSFNFDVPIKIGVFKWEEITGVEWTRFFGFELHITPFFDMALVHDKNTDTYYNPKHGWYSGGFEIIMYPIKMRSIYARISYGHDLREIKNKDGYAKRDGKPVSEIFIGIGLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PY4</accession>
    <name>Q73PY4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971274.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681862.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0661"/>
    <dbReference type="EnsemblBacteria" id="AAS11155">
        <property type="protein sequence ID" value="AAS11155"/>
        <property type="gene ID" value="TDE_0661"/>
    </dbReference>
    <dbReference type="GeneID" id="2739209"/>
    <dbReference type="KEGG" id="tde:TDE_0661"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.641"/>
    <dbReference type="eggNOG" id="ENOG5031CXE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163140_9_2_12"/>
    <dbReference type="OrthoDB" id="2070536at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="79" mass="9318" checksum="51A2FFD812AC2987" modified="2004-07-05" version="1">MSYEQYTQIETSVLNMPYEQKIQLLHKITDNLKNIKAIETANLQTKKTSRCFGIAKGEFSYPKNFDEDNEEIETNLYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PY9</accession>
    <name>Q73PY9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971269.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681849.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0656"/>
    <dbReference type="EnsemblBacteria" id="AAS11150">
        <property type="protein sequence ID" value="AAS11150"/>
        <property type="gene ID" value="TDE_0656"/>
    </dbReference>
    <dbReference type="GeneID" id="2739204"/>
    <dbReference type="KEGG" id="tde:TDE_0656"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.636"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_13_0_12"/>
    <dbReference type="OMA" id="YEWLRIH"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="142"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="357" mass="41493" checksum="32D0913F5886A055" modified="2004-07-05" version="1">MNITETGKLKLSIIIKSFFKDNFLFIFVPLLLIFLQVLILYLSNAERGLVSYISLLSISILIIFFILKFIFYYRKIKNYFDLVEQYEVNSESSDDEKFENRLDLSLSQIISLKKIKKIILEREASIYNNRKILIDQNDYFSLWIHQIKTPITSINILLQNMNSSKDEVFEIKRALLSIDNYTQMALHYLKLQSPDRDLDFIKFNLNEVLQNIFRKYRSIFIYKNIELNYKPCDLNIISDQVLFELMIEQIISNSLKYCGIDDKRGILSIYIENQNPSVLVIEDNGIGISPSDLPKIFDKGYSGLNGRLSEKATGLGLYLAREISERLGCTLTINSLQGEWTRAEVKLGTETSILTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q13</accession>
    <name>Q73Q13_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma factor regulatory protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971245.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681817.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0631"/>
    <dbReference type="EnsemblBacteria" id="AAS11126">
        <property type="protein sequence ID" value="AAS11126"/>
        <property type="gene ID" value="TDE_0631"/>
    </dbReference>
    <dbReference type="GeneID" id="2739356"/>
    <dbReference type="KEGG" id="tde:TDE_0631"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.610"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023575_0_0_12"/>
    <dbReference type="OMA" id="MSQMKGV"/>
    <dbReference type="OrthoDB" id="736514at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
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        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="23"/>
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            <end position="55"/>
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    </feature>
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            <end position="164"/>
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        </location>
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            <begin position="201"/>
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        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="489"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="708" mass="81152" checksum="DD6E93A7C5968D19" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q34</accession>
    <name>Q73Q34_TREDE</name>
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        <submittedName>
            <fullName evidence="4">3-hydroxyacyl-CoA dehydrogenase, putative</fullName>
        </submittedName>
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        <name evidence="4" type="ordered locus">TDE_0610</name>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS11105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS11105">
        <property type="protein sequence ID" value="AAS11105"/>
        <property type="gene ID" value="TDE_0610"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.590"/>
    <dbReference type="eggNOG" id="COG1250">
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="187"/>
        </location>
    </feature>
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            <end position="270"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="309" mass="33472" checksum="5B9FD583AFD4A5D8" modified="2004-07-05" version="1">MIEKGKKIKVAVVGDGTMGHGISEVFAKAGHTVQIIGLNDASLKSALDRIKLSLNEFVAEGLVSASDIDTIVGRISFSTDIQKAEDAAIVIEALPENMDLKTETFGKLEKICPQDTILATASGHSVSEVIAQVKKRDRVIATHFWFPPQLLPLVEVCGAPETSKATIDTTCELLKGIGKKPVVIDKEIDGFIGNRIQFAALREAWALYDSGVATADAIDSIVRYSIGRRYSVTGPIESADVAGLPVMVNFAAYLQPSLSNDKDPPAKLFDLAKVDGKVYNRSKAEIDKLIAARKKELFRWLAADMEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q35</accession>
    <name>Q73Q35_TREDE</name>
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        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">TDE_0609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681792.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0609"/>
    <dbReference type="EnsemblBacteria" id="AAS11104">
        <property type="protein sequence ID" value="AAS11104"/>
        <property type="gene ID" value="TDE_0609"/>
    </dbReference>
    <dbReference type="GeneID" id="2739165"/>
    <dbReference type="KEGG" id="tde:TDE_0609"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.589"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040170_0_0_12"/>
    <dbReference type="OMA" id="LPVMMLD"/>
    <dbReference type="OrthoDB" id="1746903at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="131"/>
        </location>
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    </feature>
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        <location>
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            <end position="196"/>
        </location>
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        </location>
    </feature>
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        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
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        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="296" mass="32735" checksum="F89ABD9A7BF770D5" modified="2004-07-05" version="1">MLKDYILYIILGGIIIVNGLFAVRFFIDYWKHRREAKEEPGHPILICCSSFVLYFLSTFGVSDYALSTAFYRATKWVDDKKLPGTLNTQCVLPVAVMALAYINSIEVDILTLVLCIVSQTLGSYILPRFVVKFPIKIIRRVIGFGLLGATVLILLGKMNLLPIGGELTGLTGIKLWVTVVLFAVFGAMNTIGIGSYPVTMLTVYAMGLNPVIAFPIMMGACTFSVPVGSMEYVRLGQYARKITFISSFVGILGVLLAVFVVKSMNISMLQWLVAAILVYSGVTMLHQEYGRKKQQE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q68</accession>
    <name>GATA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="1">Glu-ADT subunit A</shortName>
            <ecNumber evidence="1">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatA</name>
        <name type="ordered locus">TDE_0576</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971190.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956776.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73Q68"/>
    <dbReference type="SMR" id="Q73Q68"/>
    <dbReference type="STRING" id="243275.TDE_0576"/>
    <dbReference type="EnsemblBacteria" id="AAS11071">
        <property type="protein sequence ID" value="AAS11071"/>
        <property type="gene ID" value="TDE_0576"/>
    </dbReference>
    <dbReference type="GeneID" id="2741012"/>
    <dbReference type="KEGG" id="tde:TDE_0576"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.559"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_12"/>
    <dbReference type="OMA" id="EVSCPHF"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000241175" description="Glutamyl-tRNA(Gln) amidotransferase subunit A">
        <location>
            <begin position="1"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <sequence length="485" mass="52824" checksum="155897268508882B" modified="2004-07-05" version="1">MITDLTFTQLRDKLKNKELSSLQILRAFKDEYEKDLKHPLPLNGFVEFFEDAEEHAKKADELIAQGVSFDEKPLLGLPIAVKDNISMAGKLCTCCSRSLQGYYAPYNATVIDRLLEAGAVLMGRINMDELAMGSSTEFSCYGPSRNPVDRARTPGGSSGGSAAVVAGNQAPFSLGTETGGSVRLPASYCGIYGLKPTYGLFSRYGVVAFSSSLDQVGLFGKEAADIALGLAVMAGKDEKDETSEEADFSSLLKLSAYSKEEIASLKIAIPKEFLNTQGLDQEVKQVFDELCAWLTKNGAKLEEVSIPVLEASIPTYYTLAISEAASNLSRIDGIRFGLRKDTGKGNDELYIQTRSEGFGPEVKRRIITGNYVLSKEFSGDCYEKSLNVRAKIAQGVNEVLQKYDFIICPTAPAPAFKLNEKVDDPIAMYLSDLFTTFVNLARIPSLSVPAGKTKAGLPVGIQFCGKKFSEDRILKLAKAWEEQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QA8</accession>
    <name>Q73QA8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971149.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681678.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0535"/>
    <dbReference type="EnsemblBacteria" id="AAS11030">
        <property type="protein sequence ID" value="AAS11030"/>
        <property type="gene ID" value="TDE_0535"/>
    </dbReference>
    <dbReference type="GeneID" id="2741754"/>
    <dbReference type="KEGG" id="tde:TDE_0535"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.521"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="FVYQSHR"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="232" mass="25272" checksum="D95093F1728A070E" modified="2004-07-05" version="1">MGETIIRMENVTKLYEMGESIVHALRGISFSIDQGEFVSIMGPSGSGKSTCMNMIGCLDRPTSGILEIGGKETAKMTEKELAVLRNKTIGFVFQQYHLLPNMTVLENVMLPLRYQGVERTKRIALAKEALEHVDMGDRLSHGPNELSGGQKQRVAIARAMVTKPHIILADEPTGALDSKTGAQVLNLFKKINESGTTIVIVTHDPGIGASADRCIKLFDGNIQSDEHQVPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QE1</accession>
    <name>Q73QE1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971116.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681626.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0502"/>
    <dbReference type="EnsemblBacteria" id="AAS10997">
        <property type="protein sequence ID" value="AAS10997"/>
        <property type="gene ID" value="TDE_0502"/>
    </dbReference>
    <dbReference type="GeneID" id="2738987"/>
    <dbReference type="KEGG" id="tde:TDE_0502"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.488"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_784448_0_0_12"/>
    <dbReference type="OMA" id="EFHRENF"/>
    <dbReference type="OrthoDB" id="1360387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="354" mass="39691" checksum="0E3672D3826DB74F" modified="2004-07-05" version="1">MAKKRITLPQNFDELITAGDVEALKAVYDKCELTAHNGRYSLNTALHYGGVPDELVIWLVEQGLDVNTLDYYGRTPLYKHATLGRDTVKLLYELGGDIQKPDTYGSTPLHTAAGFFRPKIVSFLIEKDADVNAKNDMGRTPLAEALATCRNSNVVQAAEIAEMLIKAGAEVVPEMAERVEIIGKDFEFHRENFNKDSLAETEAGLEKLYALFDVKPAPKRKIHDGVSPIIVKTGSWKEQYDELWEMLIPSSGAAKTVQGEVIRITGRVQDELYRNGGVNWDKDYRNMLNSLPNHFASGTPLSEEELKETKELISNIRANGEDEEVITERLRELSVLWVLLNPTPILLGKTNYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QE8</accession>
    <name>Q73QE8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Couple_hipA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971109.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681615.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0495"/>
    <dbReference type="EnsemblBacteria" id="AAS10990">
        <property type="protein sequence ID" value="AAS10990"/>
        <property type="gene ID" value="TDE_0495"/>
    </dbReference>
    <dbReference type="GeneID" id="2738980"/>
    <dbReference type="KEGG" id="tde:TDE_0495"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.480"/>
    <dbReference type="eggNOG" id="COG3550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168268_1_0_12"/>
    <dbReference type="OMA" id="DYQGIPL"/>
    <dbReference type="OrthoDB" id="1731026at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017508">
        <property type="entry name" value="HipA_N1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13657">
        <property type="entry name" value="Couple_hipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03071">
        <property type="entry name" value="couple_hipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Couple_hipA" evidence="1">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="109" mass="12600" checksum="D588A286D1E9E9ED" modified="2004-07-05" version="1">MKNIFRTADVYVYNNFAGKLSETDEGYSFSYDKTYIKASNHPVSLTLPIREEPYKSKTLFSFFDGLIPEGWLLDIVSRNWKIDPKDRFALLLVACKDPIGNVSIREEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QK2</accession>
    <name>Q73QK2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971055.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681515.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10936">
        <property type="protein sequence ID" value="AAS10936"/>
        <property type="gene ID" value="TDE_0441"/>
    </dbReference>
    <dbReference type="GeneID" id="2740587"/>
    <dbReference type="KEGG" id="tde:TDE_0441"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.428"/>
    <dbReference type="eggNOG" id="ENOG5030KEA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2482355_0_0_12"/>
    <dbReference type="OrthoDB" id="1875269at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="89" mass="10812" checksum="84DF501B234036BA" modified="2004-07-05" version="1">MNCFKTIIELQDILFPKFYTAMDSENNEYIFLKTQDSMINSLDKVSDKTQLEAYENHIHILRFHQLWENEEPYYDVKDFPNIEVFKIRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QK5</accession>
    <name>TGT_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tgt</name>
        <name type="ordered locus">TDE_0438</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971052.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681512.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73QK5"/>
    <dbReference type="SMR" id="Q73QK5"/>
    <dbReference type="STRING" id="243275.TDE_0438"/>
    <dbReference type="EnsemblBacteria" id="AAS10933">
        <property type="protein sequence ID" value="AAS10933"/>
        <property type="gene ID" value="TDE_0438"/>
    </dbReference>
    <dbReference type="GeneID" id="2740584"/>
    <dbReference type="KEGG" id="tde:TDE_0438"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.425"/>
    <dbReference type="eggNOG" id="COG0343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_0_1_12"/>
    <dbReference type="OMA" id="GIDLFDC"/>
    <dbReference type="OrthoDB" id="1165356at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000135549" description="Queuine tRNA-ribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="1">
        <location>
            <begin position="254"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <sequence length="379" mass="43074" checksum="C6F31BD7BA331E2F" modified="2004-07-05" version="1">MKEKKEIFTLLHQDAASPARTGVLELPHGKVLTPAFMPVGTAATVKAMTKDDLDEIGFEIILANTYHLFLRPGIEVIKAAGGLHGFSDWKKNFLTDSGGFQVFSLSQLRKITEEGVKFQSHIDGSRQFLSPEIAVELQTGFNSDIQMQLDICSSFGISKTQTLADLKITMNWLDRAFAAWHNTPHEYDGALFPIVQGGFFEDLRLQSLEAILKHEPRGIAIGGLSIGEPKDLYQEYLSFTAKHIPKNKPLYVMGIGTPDYILEAVKNGVDIFDCVLPSRNARNGNLFTHEGAISIKRKEYEFDFNPIDSQCKCKVCRQYTRAYLRHLFRTKEILYSMLATYHNLAFLYSMVQDIREAIQNDSFNDYYKNFLKKYENRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QP8</accession>
    <name>Q73QP8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971009.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676751.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0395"/>
    <dbReference type="EnsemblBacteria" id="AAS10890">
        <property type="protein sequence ID" value="AAS10890"/>
        <property type="gene ID" value="TDE_0395"/>
    </dbReference>
    <dbReference type="GeneID" id="2739404"/>
    <dbReference type="KEGG" id="tde:TDE_0395"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.384"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_8_0_12"/>
    <dbReference type="OMA" id="VHMRESA"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="79"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="284" mass="30848" checksum="0512758D9F4C8288" modified="2004-07-05" version="1">MKIEKIRELCKAAYSDKQMRLGLICLLILLIIISFAPQIANFNPYEYGNDILSGLGKNGHILGTNHMGQDVFSMIIYGTATSLKVAIISALISGILGVIIGGIAGFFGGKVDQIISECINIFMMLPTFFLILLIIALFGSSIYNVMVVIGITTWPSNAKLMRAQALSIRERTYVKSAKALGENNRQILFKYIIPNGIFPVIANTTVGMSNAILTEAGLSFLGLGDPNIISWGQMIYQGKPYITTAWWISTFAGIGIVVTVTTFYLLGDGLNHILNPKNISSGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QQ1</accession>
    <name>Q73QQ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(R)-2-hydroxyglutaryl-CoA dehydratase, beta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971006.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0392"/>
    <dbReference type="EnsemblBacteria" id="AAS10887">
        <property type="protein sequence ID" value="AAS10887"/>
        <property type="gene ID" value="TDE_0392"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0392"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.381"/>
    <dbReference type="eggNOG" id="COG1775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053697_1_1_12"/>
    <dbReference type="OMA" id="CPYMYFS"/>
    <dbReference type="OrthoDB" id="1815612at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="392" mass="44301" checksum="F4EBF657797874EA" modified="2004-07-05" version="1">MIMNNLPKGFDSLAEAQQKKFLALKSLKDGGGKVIGLYCSYVPTELVYAAGAVPVSLCATSEKPISAAERDLPKNLCPLIKASYGHAITDTCPFFYFSDFIVGETTCDGKKKMFELLNDIKPTYVMHLPQNNLDPKAYPFWADEVKKLKERIEEFYNITITEDDLRQAIKDCNQERRNLVNFFELSALDPSPVSGLEQFNVKEAFGFQYDIQQKNAEIVKRTKELKEYWEKNLKGTRDERPRILVTGCPLGGVKEKILAQIEKLGAVIVGYDSCSGLRTHMEFVDEDPARDPIEAIAEKYLKTNCSVMSPNPGRLKDLDYLLDHYKADAVIECTLVACHTFNLEAHTVGKHIMQKGLPYIHIESDYSQEDAGQFATRLEAFLEVVSERKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QQ7</accession>
    <name>Q73QQ7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter, periplasmic substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971000.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681411.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0386"/>
    <dbReference type="EnsemblBacteria" id="AAS10881">
        <property type="protein sequence ID" value="AAS10881"/>
        <property type="gene ID" value="TDE_0386"/>
    </dbReference>
    <dbReference type="GeneID" id="2740318"/>
    <dbReference type="KEGG" id="tde:TDE_0386"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.375"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026974_0_1_12"/>
    <dbReference type="OMA" id="QADAVWG"/>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026045">
        <property type="entry name" value="Ferric-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002825">
        <property type="entry name" value="CfbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285017" evidence="2">
        <location>
            <begin position="21"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="338" mass="36647" checksum="B0EBF8B62A0DF59F" modified="2004-07-05" version="1">MKKIIFAALFLLLASTLVFAAGSSEKESKDLSGKTLNVVATSAYKELFDAFTAKTNVKVEFLSMSSGEVLARTRAEGKSMADVWFGGGLDAFMAAKADGLLENYVSPNSKDIPAQYKDTDGAWIAKGITVVGFIGNKDVLAEKKLPMPKTWAELADPKYKGEVIMSDPAISGTNYGAVKGLLDLFGEEKGWDYWKKINANIPFLGKRGKDPQEKTAQGEFAVGIIPADGKAFKLADDKNLTVVYPEDGIPWVPEGTAIFKSCPNLDAAKAFIDFMLTKEAQEIIARLDGKDSAQIVKPGVKGLSLGLPKDKLIKEDLSSFGKDRQRILDKFASLRSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QT4</accession>
    <name>Q73QT4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970973.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681347.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0359"/>
    <dbReference type="EnsemblBacteria" id="AAS10854">
        <property type="protein sequence ID" value="AAS10854"/>
        <property type="gene ID" value="TDE_0359"/>
    </dbReference>
    <dbReference type="GeneID" id="2741079"/>
    <dbReference type="KEGG" id="tde:TDE_0359"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.348"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_12"/>
    <dbReference type="OMA" id="LGIMLWG"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="396"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="429"/>
            <end position="436"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="635" mass="70757" checksum="7A52D637135B101E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QV6</accession>
    <name>NAGB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine-6-phosphate deaminase</fullName>
            <ecNumber evidence="1">3.5.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GlcN6P deaminase</fullName>
            <shortName evidence="1">GNPDA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glucosamine-6-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nagB</name>
        <name type="ordered locus">TDE_0337</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 6-phosphate + H2O = beta-D-fructose 6-phosphate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12172"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:75989"/>
            <dbReference type="EC" id="3.5.99.6"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-sugar metabolism; N-acetylneuraminate degradation; D-fructose 6-phosphate from N-acetylneuraminate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.6" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970951.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681305.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73QV6"/>
    <dbReference type="SMR" id="Q73QV6"/>
    <dbReference type="STRING" id="243275.TDE_0337"/>
    <dbReference type="EnsemblBacteria" id="AAS10832">
        <property type="protein sequence ID" value="AAS10832"/>
        <property type="gene ID" value="TDE_0337"/>
    </dbReference>
    <dbReference type="GeneID" id="2739336"/>
    <dbReference type="KEGG" id="tde:TDE_0337"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.326"/>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049611_0_1_12"/>
    <dbReference type="OMA" id="FNEPCSS"/>
    <dbReference type="OrthoDB" id="1828393at2"/>
    <dbReference type="UniPathway" id="UPA00629">
        <property type="reaction ID" value="UER00684"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004342">
        <property type="term" value="F:glucosamine-6-phosphate deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019262">
        <property type="term" value="P:N-acetylneuraminate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01399">
        <property type="entry name" value="GlcN6P_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01241">
        <property type="entry name" value="GlcN6P_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004547">
        <property type="entry name" value="Glucosamine6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018321">
        <property type="entry name" value="Glucosamine6P_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11280">
        <property type="entry name" value="PTHR11280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00502">
        <property type="entry name" value="nagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01161">
        <property type="entry name" value="GLC_GALNAC_ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000067033" description="Glucosamine-6-phosphate deaminase">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for enolization step" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="1">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for ring-opening step" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="For ring-opening step" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="site" description="Part of the allosteric site" evidence="1">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01241"/>
        </source>
    </evidence>
    <sequence length="270" mass="30501" checksum="C3B719055191B99C" modified="2004-07-05" version="1">MRLIIKNSYEDCSKWTADYICNKIIEFKPTKEKPFVLGLPTGSTPLGVYKELIKKHKEGILSFKHVVTFNMDEYVGLEASHPQSYHYFMMDNFFNHIDIEPKNIHILDGMAKDKKKECEDYEKAIRSYGKIHLFLGGIGADGHIAFNEPYSSLTSRTREKTLTRDTIIMNSRFFEGNEDLVPKTALTVGIGTIMDAEEVLIMATGHAKAEAVHQAVEGGVSHVWTVSALQLHPKSIIICDDAATDELKVKTVKYFLDIEKGNIETNVSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R66</accession>
    <name>Q73R66_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970841.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681127.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0225"/>
    <dbReference type="EnsemblBacteria" id="AAS10722">
        <property type="protein sequence ID" value="AAS10722"/>
        <property type="gene ID" value="TDE_0225"/>
    </dbReference>
    <dbReference type="GeneID" id="2740779"/>
    <dbReference type="KEGG" id="tde:TDE_0225"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.218"/>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155837_0_1_12"/>
    <dbReference type="OMA" id="RITWEDA"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="90" mass="10283" checksum="50AC9C9416ED18AD" modified="2004-07-05" version="1">MITAMTITEARKKITSLEDTMDYDDTISITNHGKEIFALIKWDTYESICETLEILSDEELSKNLAIGVQQIKENNLLDFDSFKKSLSCTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R81</accession>
    <name>Q73R81_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cob(I)alamin adenosyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobO</name>
        <name evidence="1" type="ordered locus">TDE_0210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.17" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970826.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666509.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0210"/>
    <dbReference type="EnsemblBacteria" id="AAS10707">
        <property type="protein sequence ID" value="AAS10707"/>
        <property type="gene ID" value="TDE_0210"/>
    </dbReference>
    <dbReference type="GeneID" id="2739367"/>
    <dbReference type="KEGG" id="tde:TDE_0210"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.204"/>
    <dbReference type="eggNOG" id="COG2109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088595_2_0_12"/>
    <dbReference type="OMA" id="HAMGEGF"/>
    <dbReference type="OrthoDB" id="1690483at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00561">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="171" mass="19310" checksum="404BC21D392CD6BE" modified="2004-07-05" version="1">MKKGYVQVYTGDGKGKTTAAFGLALRAVCAGYKVYIGQFLKGMNYSELKAPEYLPNLTIEQYGEAHFVHNDPTEKDIQRANEGLDKIEKIIMSGEYDVVIMEEVNVALLYGLFDIERILHIIKNKPESVELVLTGRYANKKIIEAADLVTEMKMIKHYFNDGVQARRGIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R93</accession>
    <name>Q73R93_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970814.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681095.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0198"/>
    <dbReference type="EnsemblBacteria" id="AAS10695">
        <property type="protein sequence ID" value="AAS10695"/>
        <property type="gene ID" value="TDE_0198"/>
    </dbReference>
    <dbReference type="GeneID" id="2739014"/>
    <dbReference type="KEGG" id="tde:TDE_0198"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.193"/>
    <dbReference type="eggNOG" id="COG4448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062004_0_0_12"/>
    <dbReference type="OMA" id="DDCGAPT"/>
    <dbReference type="OrthoDB" id="1434447at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="PTHR42110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="329" mass="36502" checksum="F1DE772F02C92F5C" modified="2004-07-05" version="1">MEILLKSYRGKIEDLYTFGSIAVVDKNGKIVYSAGDPKEVSFPRSSAKLIQALVPLSLGAKEKFNLSHEEIAQICASHSGEDFHIKTVTGILKKIGLDESALKCGPHYPFKPEVELRMKVNNEKPRDIHNNCSGKHSGMLAAAVLMKASTDDYYKPQHPVQQKIREMIELICDCKIPDDNISVDGCGVPVHSLPLYNFAFGMARMADYKNLPQNLSTHAKDIIDSITACSEYTSGTDRIDHLLVKKYPEKLVVKSGANGYFGGLLPDKKYGIAVKTYDGISKTRDIVLVHLLKKLGVIDKADYEYFDNLADKNIKNHRGETAGEVVPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RA2</accession>
    <name>Q73RA2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970805.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681078.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0189"/>
    <dbReference type="EnsemblBacteria" id="AAS10686">
        <property type="protein sequence ID" value="AAS10686"/>
        <property type="gene ID" value="TDE_0189"/>
    </dbReference>
    <dbReference type="GeneID" id="2741036"/>
    <dbReference type="KEGG" id="tde:TDE_0189"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.185"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_2_3_12"/>
    <dbReference type="OMA" id="YAYGFIM"/>
    <dbReference type="OrthoDB" id="1445898at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="262" mass="28007" checksum="5FDA75BD42BF3F99" modified="2004-07-05" version="1">MYISLQAMIFLCFCVFLAGFVDSAAGGGGLISIPAYFFVGLPAHMAIGCNKFSAACGTTFSAFRFFKHGALEWRIALVSALFSFISSYLGMKIALGIDQVFLKKAMILILPAIAVILLLKRNFGNENKSKEIPQKKTFVLAALIGACVGFYDGLIGPGTGTIAIIAYSAWMKYDLKTASGNAKLLNLASNYASLTAVLINNKVIFSIAIPAAVCGIIGNYLGAGFALKKGAAFIRPLMIVVIILLFAKLFYDVFGKMILGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RC3</accession>
    <name>Q73RC3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970783.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666599.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0167"/>
    <dbReference type="EnsemblBacteria" id="AAS10664">
        <property type="protein sequence ID" value="AAS10664"/>
        <property type="gene ID" value="TDE_0167"/>
    </dbReference>
    <dbReference type="GeneID" id="2739600"/>
    <dbReference type="KEGG" id="tde:TDE_0167"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.164"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="DRARWYP"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="233" mass="26180" checksum="A1F3A1D44E6EDBF5" modified="2004-07-05" version="1">MSTILETEHLKKTYLGKKTALYDVSLKVESGRIYGLLGPNGSGKTTFLKIIAGLIKPTAGNFKVCGKEFGIDTKKIVAFLPDKNVVYPWMTSEDAINFYADFFEDFDKNKALEMLKFMKLEPKQTVKTMSKGMIEKLNLSLTFSRSSKLYILDEPLGGTDPVAREQIIKTIIKTWTEESAILITTHLVSDIEHVFNDVAFLKEGEIVLEGDAEDLRTTRGKSIYQIYLDVFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RF0</accession>
    <name>Q73RF0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970756.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681005.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0139"/>
    <dbReference type="EnsemblBacteria" id="AAS10637">
        <property type="protein sequence ID" value="AAS10637"/>
        <property type="gene ID" value="TDE_0139"/>
    </dbReference>
    <dbReference type="GeneID" id="2739343"/>
    <dbReference type="KEGG" id="tde:TDE_0139"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.139"/>
    <dbReference type="HOGENOM" id="CLU_345100_0_0_12"/>
    <dbReference type="OrthoDB" id="30673at203691"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284668" evidence="1">
        <location>
            <begin position="24"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="820" mass="91982" checksum="1EF5371F8F98166E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RN9</accession>
    <name>Q73RN9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Formiminotransferase-cyclodeaminase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970663.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666838.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0046"/>
    <dbReference type="EnsemblBacteria" id="AAS10544">
        <property type="protein sequence ID" value="AAS10544"/>
        <property type="gene ID" value="TDE_0046"/>
    </dbReference>
    <dbReference type="GeneID" id="2741661"/>
    <dbReference type="KEGG" id="tde:TDE_0046"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.48"/>
    <dbReference type="eggNOG" id="COG3404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088419_1_0_12"/>
    <dbReference type="OMA" id="VAMVARY"/>
    <dbReference type="OrthoDB" id="1965647at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="SSF101262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FTCD_C" evidence="1">
        <location>
            <begin position="7"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="213" mass="22771" checksum="A6A57C6E51055729" modified="2004-07-05" version="1">MELVKMTVSAFVDETASDSPAPGGGSVSALAGSLASALGQMVIRLTTGKKAFASLDEKTQEEFKAQLPKLEKAQKRLVEIIDEDTQAFNAFMEALKLPKDTDEQKAKRSKAMSDATVVAMQVPLETAKTCLDVLRFLPIVALHGNKNAASDAGVAALNARSGLEGAILNVKINLGGIDDASLCEKTRAECNKMLEEGEKLKTEILKTIYSKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RP1</accession>
    <name>Q73RP1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970661.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680900.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0044"/>
    <dbReference type="EnsemblBacteria" id="AAS10542">
        <property type="protein sequence ID" value="AAS10542"/>
        <property type="gene ID" value="TDE_0044"/>
    </dbReference>
    <dbReference type="GeneID" id="2741659"/>
    <dbReference type="KEGG" id="tde:TDE_0044"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.46"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_3_12"/>
    <dbReference type="OMA" id="GHAAAKM"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="3"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="304"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="336"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="490" mass="56331" checksum="3C13CACF308C81DF" modified="2004-07-05" version="1">MLIDVKNVTFAYYGSAEPVFENLNLQLDTDWKLGLIGRNGYGKTTFLNLLQNKLEYSGKIISPVSFEYFPYVLEEKNTTREIVLSRLPHIEGWQLDCELSLLKASSEIADRPFKTLSSGEQIKVLLAAMFLHENSFILIDEPTNHLDVYGRAAVADYLKNKKGFILVSHDRDFLNRTVDHVLTIEKNNIYVQNGNYDTWEENKIKQDNFEIEKNIQLRKEIKRLKAAARQKAGWSDLKEKSKHGQWIYDRGYVSHKASKMMKRAKSIERNADKAVAEKEKLLKNIETIEDIPMRPLTHHAKHLIEASALSVSYGKKNIFSPVDFSIEAGGVLSLNGKNGAGKSSILKLLMGEKIEFSGTLKKAQDLKISYIPQNFDFLKGQLFDFIEESNIDKTVFLTTLRKLNFPQDNFDKNMETYSSGQKKKVLLTRSICESAHFYIWDEPLNYIDIISRLQIERMILKYGPTVILVEHDKKFNEKVSTDFVELLPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7IUZ1</accession>
    <name>F7IUZ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheW-1</name>
        <name evidence="3" type="ordered locus">TDE_1492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972098.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671242.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="F7IUZ1"/>
    <dbReference type="STRING" id="243275.TDE_1492"/>
    <dbReference type="EnsemblBacteria" id="AAS12009">
        <property type="protein sequence ID" value="AAS12009"/>
        <property type="gene ID" value="TDE_1492"/>
    </dbReference>
    <dbReference type="GeneID" id="2739893"/>
    <dbReference type="KEGG" id="tde:TDE_1492"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1431"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_597086_0_0_12"/>
    <dbReference type="OMA" id="LVDIMQV"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="CheR-type methyltransferase" evidence="1">
        <location>
            <begin position="228"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="444" mass="49706" checksum="2C1CE0F6A1D6108E" modified="2011-07-27" version="1">MEEMKELKVNTGVGIGDTDSLHEQMIVVDFKMVTFSLAGKDYAIDIMRVKEIAKAGNFTYVPNTSPFVLGVYNLRGDIIPIIDLRIFFNIPVPARKKNQPESMVIINVQDQTFGVVVDFIDKVVGVSSSTIQPPHPIFGDINIKYIHGVVENGGHLYILLDVDKIFASRQKEEVKEDLAPVAASVVKEPVKLQGGQSSENLDIKFIGDTLSAMGKFYISAVNEDWVKERYLEWKDIRPSGSLQIQSEKDAGEFLSSFLSPFTKSFWSEAYINAYYKMLPENASSVINVWCIGCGQGYEAYSLAVLLKMRYPRAHVKIYANDSDLLAISNAPMLSVPDDIASGIYEPHITKTASGNLTFSKEIKDMILFEYHDCTHQNAVPDVDIIVARDVLSFMNPNVQRTLIEEFREKLKDSGLIILGHNEAMPKQDGWLRNSSGDIVIFTKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1998-12-15" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>O87545</accession>
    <name>GYRB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA gyrase subunit B</fullName>
            <ecNumber evidence="1">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gyrB</name>
        <name type="ordered locus">TDE_0002</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Gene" volume="253" first="259" last="269">
            <title>Molecular characterization of the gyrB region of the oral spirochete, Treponema denticola.</title>
            <authorList>
                <person name="Greene S.R."/>
                <person name="Stamm L.V."/>
            </authorList>
            <dbReference type="PubMed" id="10940564"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(00)00254-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="1">Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="1"/>
    <dbReference type="EMBL" id="AF083949">
        <property type="protein sequence ID" value="AAC62070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970619.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666949.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O87545"/>
    <dbReference type="SMR" id="O87545"/>
    <dbReference type="STRING" id="243275.TDE_0002"/>
    <dbReference type="EnsemblBacteria" id="AAS10500">
        <property type="protein sequence ID" value="AAS10500"/>
        <property type="gene ID" value="TDE_0002"/>
    </dbReference>
    <dbReference type="GeneID" id="2741616"/>
    <dbReference type="KEGG" id="tde:TDE_0002"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_12"/>
    <dbReference type="OMA" id="LWETTMH"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0799">Topoisomerase</keyword>
    <feature type="chain" id="PRO_0000145356" description="DNA gyrase subunit B">
        <location>
            <begin position="1"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="423"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="1">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <sequence length="638" mass="71392" checksum="AD0DFFA091C2D5A6" modified="1998-11-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-06-07" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>P61748</accession>
    <name>GPDA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="1">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpsA</name>
        <name type="ordered locus">TDE_2090</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972691.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679888.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61748"/>
    <dbReference type="SMR" id="P61748"/>
    <dbReference type="STRING" id="243275.TDE_2090"/>
    <dbReference type="EnsemblBacteria" id="AAS12610">
        <property type="protein sequence ID" value="AAS12610"/>
        <property type="gene ID" value="TDE_2090"/>
    </dbReference>
    <dbReference type="GeneID" id="2740329"/>
    <dbReference type="KEGG" id="tde:TDE_2090"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1974"/>
    <dbReference type="eggNOG" id="COG0240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033449_0_0_12"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="OrthoDB" id="1419877at2"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000138050" description="Glycerol-3-phosphate dehydrogenase [NAD(P)+]">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="274"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <sequence length="357" mass="38855" checksum="C546E87A64886E06" modified="2004-06-07" version="1">MNDKIAIIGAGSWGTAVACSLGKNGHRVVLWSHTAGVADSINTEHINVKYLPKHKLPKTVSASTDMEEVCKDASFIFLASPSLYLTSAVEELLKFAPFSHDDGEMPYPTIAVLTKGFIPDENGEPQFIIDVLEKMLPDFYKNHLVYVAGPSHGEEVAEGKLTGLIAASQNPMCSIRCREILRSRSLLVYSSLDIIGVQVCAAAKNVVAVAFGVLDALTVTSDIFGDNTESLLLAAGLNEIQTIGRAMGATHPETFTSISGVGDLDVTCRSKYGRNRRFGNEIITKKILLSFENLDDLIKNIDKIGYLPEGVVACKYLNILAEKRNLKLPICSGLYKILNKELKPLDLIENLLQGDTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-05" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>P62221</accession>
    <name>RECA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recA</name>
        <name type="ordered locus">TDE_0872</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971482.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682153.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P62221"/>
    <dbReference type="SMR" id="P62221"/>
    <dbReference type="STRING" id="243275.TDE_0872"/>
    <dbReference type="EnsemblBacteria" id="AAS11363">
        <property type="protein sequence ID" value="AAS11363"/>
        <property type="gene ID" value="TDE_0872"/>
    </dbReference>
    <dbReference type="GeneID" id="2740919"/>
    <dbReference type="KEGG" id="tde:TDE_0872"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.842"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040469_3_3_12"/>
    <dbReference type="OMA" id="DYGEQAL"/>
    <dbReference type="OrthoDB" id="1080436at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000122885" description="Protein RecA">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="78"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="414" mass="44639" checksum="6F77CBE75F67DB39" modified="2004-07-05" version="1">MAKAKNEVPAVANPDDKLKALEAARLQIEKQFGQGSLMKLGNNSAIGNIEIIPSGSILLDEALGIGGYPRGRIIEIFGPESSGKTTIALHAVAEAQKQGGIAAFIDAEHALDPQYAKALGVNIDELWVSQPDTGEQALEIAESLVRSGAVDVIVIDSVAALTPQAEIAGEMGDSHMGLQARLMSQALRKLTAIIGKSNCMIIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDVRKIETLGKDDDEAWGNKIRVKVVKNKVAPPFRKVEMEILFGKGVCPYGSLLDSAVKQEIIGKSGSWYSYGDDKIGQGRPNAVKFLEENIDIAQKIEKELREKLFPGRPFVSSFVEKTKEQKEAQEKAVEALKKEEGSKEDALTGNKDETDDSAQKNSAASKAKRAEVVGLPADDSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J47</accession>
    <name>Q73J47_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973327.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667037.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2729"/>
    <dbReference type="EnsemblBacteria" id="AAS13246">
        <property type="protein sequence ID" value="AAS13246"/>
        <property type="gene ID" value="TDE_2729"/>
    </dbReference>
    <dbReference type="GeneID" id="2740948"/>
    <dbReference type="KEGG" id="tde:TDE_2729"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2577"/>
    <dbReference type="eggNOG" id="COG3714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079086_0_1_12"/>
    <dbReference type="OMA" id="AHICNAY"/>
    <dbReference type="OrthoDB" id="1967817at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="YhhN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="PTHR31885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS13246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="233" mass="25973" checksum="ACA69FACE09AD2C0" modified="2004-07-05" version="1">MYNECLDPLCIAALALFLVISIIHLIKCFQQRQKWADMTKFMLMPALLLFFLAFSFVSIKTFSVLNVLIIIALIFSFLGDVALLFDWEKQNFALGIFFFAITQISYIVFAILGVKVDNIPLIPGIVTAVIFLISIIYAVMRTKKYLKGFKPIVIVYALIISSMSWLFIVFAFATQSLALILAAIGSVFFVISDTMVATKYFLGGKAGMRFLIMKTYILAQLLIVLGAIGIIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J66</accession>
    <name>Q73J66_TREDE</name>
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        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973308.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673471.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2710"/>
    <dbReference type="EnsemblBacteria" id="AAS13227">
        <property type="protein sequence ID" value="AAS13227"/>
        <property type="gene ID" value="TDE_2710"/>
    </dbReference>
    <dbReference type="GeneID" id="2739297"/>
    <dbReference type="KEGG" id="tde:TDE_2710"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2559"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_12"/>
    <dbReference type="OMA" id="ATMFTED"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="454" mass="49836" checksum="723AD614A808C788" modified="2004-07-05" version="1">MKLKFLGQTTAQRRELILTASPLKTLIILSLPALMMAMLQAMMPFTDGLFINRLTDHVTASAVSFSQPIISIVLALGQGLSVGATAIIGQLNGRGDIDESRKTATQIFVFAFLLGLVSIPLLFIIGTIISYTLKSEIAPLVFRYISLYCLVMPLSFMESIYNGIKNANGKPEAPFFRMIIMLIIKIIGNFIFLYLLRMKIDGCVLASLLANLVVAAWMFYDLFLKKSPDKLSLKKFKFSYPTLKELLHVGFPAMLNYAFVFLGFFLINNEMEPYGAVILNGQSIASNISTICFNIPGCFSAAVTTMVSMNIGSGNPKKAKRACLLGCITSAISGAVLIAIIVPSSAYLVSMFKPEIPEIGDIAVAALHIYTYSVIGFGVCMTVQGAFIGLGKTKIPLMLGVLRIWLLRYIFILATERYLSYYSIYWGNLFSNITAGLVAVILILNTKWVSGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J82</accession>
    <name>Q73J82_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2694</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973292.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680730.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73J82"/>
    <dbReference type="STRING" id="243275.TDE_2694"/>
    <dbReference type="EnsemblBacteria" id="AAS13211">
        <property type="protein sequence ID" value="AAS13211"/>
        <property type="gene ID" value="TDE_2694"/>
    </dbReference>
    <dbReference type="GeneID" id="2739281"/>
    <dbReference type="KEGG" id="tde:TDE_2694"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2544"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025733_0_0_12"/>
    <dbReference type="OMA" id="HIRIERY"/>
    <dbReference type="OrthoDB" id="167430at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011191">
        <property type="entry name" value="Uncharacterised_Tp_vWA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008381">
        <property type="entry name" value="TP0020_vWA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284551" description="VWFA domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="29"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="740" mass="79883" checksum="9AC7D59994753049" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JA0</accession>
    <name>Q73JA0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LPG_synthase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973273.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667127.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2675"/>
    <dbReference type="EnsemblBacteria" id="AAS13192">
        <property type="protein sequence ID" value="AAS13192"/>
        <property type="gene ID" value="TDE_2675"/>
    </dbReference>
    <dbReference type="GeneID" id="2741120"/>
    <dbReference type="KEGG" id="tde:TDE_2675"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2527"/>
    <dbReference type="eggNOG" id="COG4866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058411_0_0_12"/>
    <dbReference type="OMA" id="NRDRSDY"/>
    <dbReference type="OrthoDB" id="1502336at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016732">
        <property type="entry name" value="UCP018688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41373">
        <property type="entry name" value="PTHR41373"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018688">
        <property type="entry name" value="UCP018688"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LPG_synthase_C" evidence="7">
        <location>
            <begin position="27"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS13192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="296" mass="34871" checksum="478307FB3144E7E9" modified="2004-07-05" version="1">MSIPQYPEFAPISLDMQSEMEFYLKRLPDGISELTFLNLYLFRHNYKYQVTKTEKLLIIIGEYKGESFFITPCCTVDVEITKELLAKYKKWMILSKSFLDNNTNVFNLPFLKELKIEEDRDNFDYVYLRKDLAELKGKDFHKKKTHINKFEKSYDKIKIEPLTLENVEDAKKVLEEWNSTKPDSNPENSDYEAALEALSILSRTSMMGIILYVWNEPVAWTLAEITQNNKTAVILFEKALASYKGSFQYINYAFAGYLPEYIEFINREQDLGDEGLRQAKMTYKPIKFIKKYRILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JD8</accession>
    <name>Q73JD8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973235.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2637"/>
    <dbReference type="EnsemblBacteria" id="AAS13154">
        <property type="protein sequence ID" value="AAS13154"/>
        <property type="gene ID" value="TDE_2637"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2637"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2493"/>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100506_0_0_12"/>
    <dbReference type="OrthoDB" id="1696971at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="174" mass="19761" checksum="8E250E8749A4600A" modified="2004-07-05" version="1">MPEDISLSLEDCRRYMNRAYGCKSGHGTPIHVTLIPPFRLHKDYSTDDLIRAIEKEVLPKGLGFTAHIDNFDAFGDRTLFAKVVADENWTRLRDETVKAILNACPGCTKKDRRPFQPHATVSNRDIPPGVTAKALQVMNELNIAEDFPVDNITIFERKANRWEADVTMELSIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JE3</accession>
    <name>Q73JE3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter, ATP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973230.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680653.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2632"/>
    <dbReference type="EnsemblBacteria" id="AAS13149">
        <property type="protein sequence ID" value="AAS13149"/>
        <property type="gene ID" value="TDE_2632"/>
    </dbReference>
    <dbReference type="GeneID" id="2740806"/>
    <dbReference type="KEGG" id="tde:TDE_2632"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2488"/>
    <dbReference type="eggNOG" id="COG4172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_2_12"/>
    <dbReference type="OMA" id="DPMTRLD"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="331"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS13149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="564" mass="62359" checksum="3085BB5610AFDAB5" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JH1</accession>
    <name>Q73JH1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TSPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973202.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2604"/>
    <dbReference type="EnsemblBacteria" id="AAS13121">
        <property type="protein sequence ID" value="AAS13121"/>
        <property type="gene ID" value="TDE_2604"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2604"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2462"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_562494_0_0_12"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSPc" evidence="2">
        <location>
            <begin position="260"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="516" mass="59824" checksum="42F4CA124D6BC3AE" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JH9</accession>
    <name>Q73JH9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973194.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667244.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2596"/>
    <dbReference type="EnsemblBacteria" id="AAS13113">
        <property type="protein sequence ID" value="AAS13113"/>
        <property type="gene ID" value="TDE_2596"/>
    </dbReference>
    <dbReference type="GeneID" id="2741300"/>
    <dbReference type="KEGG" id="tde:TDE_2596"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2454"/>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075825_0_0_12"/>
    <dbReference type="OMA" id="LKWSHEE"/>
    <dbReference type="OrthoDB" id="1953900at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284556" evidence="2">
        <location>
            <begin position="19"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="193"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="320" mass="36558" checksum="904682EC1566C2BD" modified="2004-07-05" version="1">MKKILILFFLLFTVNAFTQNYADYMSSGLDAYARSDWSSALFSFQKAMEVSKNSLDEPLYWLIMANASARNYTVALNDIETFLKRFPNSSKAAEVIYQQGRICCLSAKHDQSINILYGFLRKYPNHRQTASAYYWIGENLYMVGRLKDARTIFSRVIIDYPSSAKVEPSRYKIALIDQASTQDELLKLLKISHEELLKLSEESEKNKKIYEQTIAAYQRQSSDAGGDMRIAELSEQLKMERKHNEELHDQLVMLELKNQELLATLAKMDAKYTSEMAADGETPAADYSDPKAKRAAIEALIKKAKILQSMYNQLLEGNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JL1</accession>
    <name>Q73JL1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">purF</name>
        <name evidence="11" type="ordered locus">TDE_2407</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973006.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680342.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2407"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="EnsemblBacteria" id="AAS12925">
        <property type="protein sequence ID" value="AAS12925"/>
        <property type="gene ID" value="TDE_2407"/>
    </dbReference>
    <dbReference type="GeneID" id="2740709"/>
    <dbReference type="KEGG" id="tde:TDE_2407"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2273"/>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_3_1_12"/>
    <dbReference type="OMA" id="ENAQPTF"/>
    <dbReference type="OrthoDB" id="267682at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="15"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS12925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="487" mass="53173" checksum="DB0B0C21DE27CE33" modified="2004-07-05" version="1">MSKDDIFKSSLGEECGIAAVWDSNSYKTENPERLPFRPDDAARSVFYALFSLQHRGQEAAGMAVSNGKHIRVFKKPGLVSNIFTEHDISNLQGYAAIGHTRYSTTGSSSFGNIQPFYIETMYGPIALAHNGNLVNAPHLRQKLLERGVGLSSTSDTEVMIMMLAAAKGDSWAERIASCMREWEGAFSIAVLTVEGIYIARDPWGFRPLCVGSFQEGVSVAASESCALLTLGCRDVTEVKAGEILKLVDNGAELCMRIPPKEPLSPCIFEYVYFARPDSVWNNASVHVSRVNFGKELAKSSPVEADIVIAIPDSSRSAAIGYSQESGIPYDEGFSKNRYIGRTFIQPTQKLRDQGVAMKFNVLSEAVEGKRIVVVDDSIVRGSTMGPLIKMLRGAGAKEVHIRISSPPVRYSCFMGVDMGDPENLIAHKKSVEEIREHIGADSLVYLSQESMLKAMKDAGANTHFCCACFDGKYPVDVSGAADKNSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JL4</accession>
    <name>Q73JL4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RNA polymerase sigma-54 factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_2404</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-54 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973003.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680335.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2404"/>
    <dbReference type="EnsemblBacteria" id="AAS12922">
        <property type="protein sequence ID" value="AAS12922"/>
        <property type="gene ID" value="TDE_2404"/>
    </dbReference>
    <dbReference type="GeneID" id="2740706"/>
    <dbReference type="KEGG" id="tde:TDE_2404"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2270"/>
    <dbReference type="eggNOG" id="COG1508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020569_0_1_12"/>
    <dbReference type="OMA" id="NPPAIEF"/>
    <dbReference type="OrthoDB" id="1906842at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="10">
        <location>
            <begin position="79"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="9">
        <location>
            <begin position="299"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS12922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="463" mass="52222" checksum="538C00C660EDB616" modified="2004-07-05" version="1">MLLKQRQQQILSQKMVMNQQMLNAVAMLNLSSEELQEEVIKEVKRNPALVFKTSSRVSAASAEEGDKHQSFLESIEDDSRKTLQAHLIEQAGESITDEYVLDAAMLIIQNLDQNGFYWVPLEELFAGLLAEKKINHAEIKKALNIVRRFEPIGCACSGFKESLIVQAGILCESPKTHEILDIYKTIYSLCVKIIKEHYEVLVFVSDLKLFIKKLAQKKIDIDLETAEELAGLIDALNPKPGLAYASKGDGEKFITPIAEIKREGNEIKIIINDEEVPALEISPEYEKIKNSGSKEEKKEASEFLNKAALFMNVLAYRNQTILKVLTALVNFQEAFFLGRPCKPSSEGESDKMQAGYLKPLKQIDIAEIVGLSPSTVSRVSNQKYIRCEWGLFEIKDLFSPEVSGGLSKDFVEKAIQEIIESDTEKKTDTRISQILKERGIDIAVRTVNKYRKEMGLPSSYHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JR2</accession>
    <accession>Q73L32</accession>
    <name>Q73JR2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ISTde1, transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0039</name>
        <name evidence="3" type="ordered locus">TDE_2033</name>
        <name evidence="4" type="ordered locus">TDE_2472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405</strain>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970656.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972636.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973070.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679811.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0039"/>
    <dbReference type="EnsemblBacteria" id="AAS10537">
        <property type="protein sequence ID" value="AAS10537"/>
        <property type="gene ID" value="TDE_0039"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12547">
        <property type="protein sequence ID" value="AAS12547"/>
        <property type="gene ID" value="TDE_2033"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12989">
        <property type="protein sequence ID" value="AAS12989"/>
        <property type="gene ID" value="TDE_2472"/>
    </dbReference>
    <dbReference type="GeneID" id="2741654"/>
    <dbReference type="KEGG" id="tde:TDE_0039"/>
    <dbReference type="KEGG" id="tde:TDE_2033"/>
    <dbReference type="KEGG" id="tde:TDE_2472"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1918"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041517_0_2_12"/>
    <dbReference type="OMA" id="HELNIQT"/>
    <dbReference type="OrthoDB" id="1637053at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="134"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="394" mass="46146" checksum="C8CE200A0BD596A3" modified="2004-07-05" version="1">MEEKLNMGKKERTRGKILAMVVERQITLKQAAIKMQVCYRQAKRIYKRYLEQGDKGLLHKSLGKPSSKRVDENIKKKCLELYAEKYHDFGPTLAAEKLEELDGIKINHETLRRLLIKAGLWSRKRRRNIHRSRRERRECFGQMLQFDGSHHKWFEQRGPKCCLMNIVDDATGMTQSFLTEQETTEAAMRLLWGWIDCHGIPQAVCCDKKNAYVITREPTMSEIIKNVRPKTPFQKACEKLGIQIIVAHSAQSKGRVERNHSVYQDRFVKELRLAKINTIEKANAFLQKEYLPKINKKFAIAPLDSQDGHAPCPSKEQLANIFCYEEQRVVSNDFVIRYENRLFQITKSNRNIPRPKTNILLRELLDGTIKLIWNNKELDFLEITKEYLKEVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JW4</accession>
    <name>Q73JW4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973121.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2523"/>
    <dbReference type="EnsemblBacteria" id="AAS13040">
        <property type="protein sequence ID" value="AAS13040"/>
        <property type="gene ID" value="TDE_2523"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2523"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2387"/>
    <dbReference type="HOGENOM" id="CLU_1539351_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="174" mass="20330" checksum="6FF0BA36E7FE25C2" modified="2004-07-05" version="1">MKRLKRFFRMFFYFEKIEKGSMWSSIFFNIIEAIRPLCLLYLSKIIIEAVTSQSLLSEVLRSTLILLTAFMLLSIISGILEKRFMYHLKCFSKKHTMEKALKILRLNFELTEQNEFQNDLNSIKQFERFIVFSHGDFMRKTGTSVGGFIGAGIALYFFIGLFNSQGFMGLSEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JZ8</accession>
    <name>Q73JZ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973139.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2541"/>
    <dbReference type="EnsemblBacteria" id="AAS13058">
        <property type="protein sequence ID" value="AAS13058"/>
        <property type="gene ID" value="TDE_2541"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2541"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2404"/>
    <dbReference type="eggNOG" id="COG2933">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051814_0_0_12"/>
    <dbReference type="OMA" id="FQGETDH"/>
    <dbReference type="OrthoDB" id="902245at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsJ" evidence="1">
        <location>
            <begin position="133"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="314" mass="36189" checksum="152BE1E5BD3A0FB6" modified="2004-07-05" version="1">MEIKNLPKDASVYGNIIYRENFPKDVFWSRLCMEEPFMAEFLSISEAADILRSIQRNWAFVPFNCFRRAELIEKKLPFISKKERNFPYDVPSAEMGIWTLLNENQIFASAKTSSPFPRGEIFFKEDKINPPSRAYLKMWEALTLLNFYLKKYQEKNSLAEKTEAMTTASFGKKNSLPAADSVCLDAGACPGGWSWVLDSLGCKIIAIDRSPLRPDLMAKKNIEFIKHDAFTLKPEDIGKIDWLCSDVICYPPRLYDWIIKWIDSDLCEKFICTIKMQGEPDNETVKKFAAIPNSKIVHLTANKHELTWLKAPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K25</accession>
    <name>Q73K25_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DbpA RNA binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973190.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680577.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2592"/>
    <dbReference type="EnsemblBacteria" id="AAS13109">
        <property type="protein sequence ID" value="AAS13109"/>
        <property type="gene ID" value="TDE_2592"/>
    </dbReference>
    <dbReference type="GeneID" id="2741296"/>
    <dbReference type="KEGG" id="tde:TDE_2592"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2450"/>
    <dbReference type="eggNOG" id="COG0724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090659_0_0_12"/>
    <dbReference type="OMA" id="IRIHDKY"/>
    <dbReference type="OrthoDB" id="1837600at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DbpA" evidence="1">
        <location>
            <begin position="103"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="208" mass="23854" checksum="50F6DA76CC82FB35" modified="2004-07-05" version="1">MSNKIRIEDEEQLISSLKDLIEAIKTQESPEELNLYRRIFKKAVPLTMRSYVAAYLIKQAGIGGSRIYKKDNRNGLGKGTFKQNSARPSRPKVILAEEESTSLFIGVGRKRGIFPKDIITLLIQGAGISREHIGDIRILDNYCFVQVMQNEAETIIEKLNNSYYRGKNLTVSHSRRPEDDNFEDSETFEHIENYAEEENNHSQTENEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K90</accession>
    <name>Q73K90_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972929.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12848">
        <property type="protein sequence ID" value="AAS12848"/>
        <property type="gene ID" value="TDE_2329"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2329"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2198"/>
    <dbReference type="HOGENOM" id="CLU_3159002_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="48" mass="5716" checksum="8E813C9D1DB46A61" modified="2004-07-05" version="1">MLFGNVQCEAYIPRQENTDNWKCKRLMGFLKITPARPFKRRQGGVIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K99</accession>
    <name>Q73K99_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-24 factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972920.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680233.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2320"/>
    <dbReference type="EnsemblBacteria" id="AAS12839">
        <property type="protein sequence ID" value="AAS12839"/>
        <property type="gene ID" value="TDE_2320"/>
    </dbReference>
    <dbReference type="GeneID" id="2739415"/>
    <dbReference type="KEGG" id="tde:TDE_2320"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2189"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_12"/>
    <dbReference type="OMA" id="LVDMQGY"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="131"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="213" mass="24779" checksum="71E37E1AE33DFEF4" modified="2004-07-05" version="1">MIKFSNLLRKESPEAVQDRLLCKAVLAGNTEAFSLIAAKYQKRVYSLGMSFFKNHDDSEDFVQDIMLKTFSALPKFRGESSFSTWLMRIAYNSAINSVKRKREFVSAFDDFEIKTNDLTPEERQIQNCVKNAIRRAVNDLPEKYRICIDLYFFYDMPYADIESITGIPVNTIKSHIFRSKKILKTELENQGIYGQEESPEYPVLFKLNLAYDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KA2</accession>
    <name>Q73KA2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemolysin III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hlyIII</name>
        <name evidence="7" type="ordered locus">TDE_2317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972917.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680231.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2317"/>
    <dbReference type="EnsemblBacteria" id="AAS12836">
        <property type="protein sequence ID" value="AAS12836"/>
        <property type="gene ID" value="TDE_2317"/>
    </dbReference>
    <dbReference type="GeneID" id="2739412"/>
    <dbReference type="KEGG" id="tde:TDE_2317"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2186"/>
    <dbReference type="eggNOG" id="COG1272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051078_1_1_12"/>
    <dbReference type="OMA" id="HEVFHSL"/>
    <dbReference type="OrthoDB" id="1659567at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="217" mass="24004" checksum="C218B93FD396FB11" modified="2004-07-05" version="1">MKEEKIKRRYSIGEEIANAVTHGIGVGLSIAALVLLVIRAARYAPPDLKAGYVVGFAIFGASLIILYLFSTLYHALPLKAKKVFGIFDHCSIYILIAGTYTAYCLSALHGAVGWTIFGIIWGLAVLGIVLYSIFGSRARILSVITYIPMGWLIIFAAKPLKEQLPLLSFKFLIIGGIIYTAGCIFYAMKKVKWAHSIWHLFVIGGSIMHFFSLYYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KF0</accession>
    <name>Q73KF0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972868.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12787">
        <property type="protein sequence ID" value="AAS12787"/>
        <property type="gene ID" value="TDE_2268"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2268"/>
    <dbReference type="HOGENOM" id="CLU_3206549_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="45" mass="5098" checksum="D0258A70BDFA93CE" modified="2004-07-05" version="1">MASAWLAGLKFTHFAGEVEQRRAQRKPPEAVKPNRQNVWCGAVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KJ9</accession>
    <name>Q73KJ9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase I</fullName>
            <ecNumber evidence="3">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972819.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680071.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2219"/>
    <dbReference type="EnsemblBacteria" id="AAS12738">
        <property type="protein sequence ID" value="AAS12738"/>
        <property type="gene ID" value="TDE_2219"/>
    </dbReference>
    <dbReference type="GeneID" id="2739495"/>
    <dbReference type="KEGG" id="tde:TDE_2219"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2096"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485649_0_0_12"/>
    <dbReference type="OMA" id="IPENCYF"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="4">
        <location>
            <begin position="140"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="4">
        <location>
            <begin position="475"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="561" mass="64694" checksum="296EFA3E684DBD1E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KK6</accession>
    <name>Q73KK6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Galactokinase</fullName>
            <ecNumber evidence="9">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">galK</name>
        <name evidence="13" type="ordered locus">TDE_2212</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="9"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972812.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680060.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2212"/>
    <dbReference type="EnsemblBacteria" id="AAS12731">
        <property type="protein sequence ID" value="AAS12731"/>
        <property type="gene ID" value="TDE_2212"/>
    </dbReference>
    <dbReference type="GeneID" id="2739488"/>
    <dbReference type="KEGG" id="tde:TDE_2212"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2089"/>
    <dbReference type="eggNOG" id="COG0153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_12"/>
    <dbReference type="OMA" id="NTHQDYK"/>
    <dbReference type="OrthoDB" id="1388391at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00246">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022963">
        <property type="entry name" value="Galactokinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="4 9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="12">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="10">
        <location>
            <begin position="122"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="11">
        <location>
            <begin position="295"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="41"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="131"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS12731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="399" mass="44704" checksum="8485FF96E1E211E8" modified="2004-07-05" version="1">MNLKQDTALEALKDTFISFYGNSEEKIIFAASPARINIIGEHIDYNGGLVLPAAVNLYLRIALRKRKDKKILYRSMKTEKIFEFELDGNLGFDKENDFANYLNGMFLFLKERGLKADTGFELLITSDIPQGSGISSSAALELCFGKIISHAFGFELDGIEFAKIGRRVENEFLGLKSGIMDQFAIAMGKKNQAILLDTSSLNYEYIPLETEPYRIVIMNSNKPRKLTESKYNERKEECEKALAFLQKKTDIDFLCDLSVSDFEKLEEDLISNLGEKLFRRVRHCVTEMDRVRRSAEALKNKDLKLLGASLNQSHLSLKDDYEVTGKELDALFFAAIKEKSCIGARMTGAGFSGCAIAIVHKDGFEEFAERVGKAYTENTGFTASFFACQASDGVSVISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KN1</accession>
    <name>Q73KN1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972787.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680032.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2186"/>
    <dbReference type="EnsemblBacteria" id="AAS12706">
        <property type="protein sequence ID" value="AAS12706"/>
        <property type="gene ID" value="TDE_2186"/>
    </dbReference>
    <dbReference type="GeneID" id="2740208"/>
    <dbReference type="KEGG" id="tde:TDE_2186"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2063"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_9_12"/>
    <dbReference type="OMA" id="FAIPSMG"/>
    <dbReference type="OrthoDB" id="164380at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="19"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="445"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="551" mass="61110" checksum="559057571CD888DE" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KQ9</accession>
    <name>Q73KQ9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972759.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679996.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2158"/>
    <dbReference type="EnsemblBacteria" id="AAS12678">
        <property type="protein sequence ID" value="AAS12678"/>
        <property type="gene ID" value="TDE_2158"/>
    </dbReference>
    <dbReference type="GeneID" id="2739144"/>
    <dbReference type="KEGG" id="tde:TDE_2158"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2039"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_12"/>
    <dbReference type="OMA" id="MYRGEQV"/>
    <dbReference type="OrthoDB" id="870493at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="278"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="311"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="502" mass="56454" checksum="77ADD16F61A8084B" modified="2004-07-05" version="1">MNTAVELKDVSFIYESSKDGRANLKKTSLNIKKGEFLLVTGISGCGKSTLTKCINGLIPRFYEGEFSGSVFINEKDISNFSIDEISKDIGSVFQSPKSQFFTDDVISELSFPCENYGISRDEIIERIAEVCSILHIENLLTEKLESLSNGQKQKIAIASILTLRPKIIVLDEPSSNLDFNSILILADILKILKQRGFTVIIAEHRLHYLKDLFDRVIYINEGSIQNEYTREEFLALTNTELNSKGLRSLHLFTNENEAEPIGPVHNKFNSDTEAEKICSLSDISFSFKDGTEILNSVNLDLYKNDIAALTGKNGAGKTTLAKIISGIYRQSAGSIKFGEKILNEKERVSRTNFVLQDVEYQLFGADVFSELLIGNKQLENVNEKIEKALKKLNLYDYKDEHPFSLSMGQKQRLIIAATYVRGCPLTILDEPTSGLDYGNMVRVGELIEEIAETSAVLIITHDFEFISKICNRLILLKDKKIALDSRLEKNDKKLESIFSTYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KR0</accession>
    <name>Q73KR0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972758.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2157"/>
    <dbReference type="EnsemblBacteria" id="AAS12677">
        <property type="protein sequence ID" value="AAS12677"/>
        <property type="gene ID" value="TDE_2157"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2157"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2038"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076847_3_0_12"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="237" mass="26303" checksum="B87C5653B8F6D638" modified="2004-07-05" version="1">MDPRTIVFLNIMLSLITTISSSISANIFIFLVSLGIVCLFKMYKKAVKYIFIFFLALALPFGIKALFGLPIQFLINSVSLIAMGVQKFLPFLMAAMVIFNKVDTKSLVSSLNKMKLPKGIMLGFTVAVRFLPTIKKEMTIITNSMKMRGIEIGTKNIFFHPIQSLEYALVPVLFRATSLADDMTAAALVKGAESPKTAAELFKIKFGIIDYVFALSSIFVVGAAIIFDFDSVFMRLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-10-11" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KR6</accession>
    <name>Y2151_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0178 protein TDE_2151</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_2151</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0178 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972752.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679987.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KR6"/>
    <dbReference type="STRING" id="243275.TDE_2151"/>
    <dbReference type="EnsemblBacteria" id="AAS12671">
        <property type="protein sequence ID" value="AAS12671"/>
        <property type="gene ID" value="TDE_2151"/>
    </dbReference>
    <dbReference type="GeneID" id="2739137"/>
    <dbReference type="KEGG" id="tde:TDE_2151"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2032"/>
    <dbReference type="eggNOG" id="COG1671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106619_2_0_12"/>
    <dbReference type="OMA" id="DADSCPK"/>
    <dbReference type="OrthoDB" id="1890924at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00489">
        <property type="entry name" value="UPF0178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003791">
        <property type="entry name" value="UPF0178"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35146">
        <property type="entry name" value="PTHR35146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02639">
        <property type="entry name" value="DUF188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176017" description="UPF0178 protein TDE_2151">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00489"/>
        </source>
    </evidence>
    <sequence length="155" mass="17397" checksum="F17051D2A0372B3D" modified="2004-07-05" version="1">MKIWVDADSCPVRIRQITAKAGERLKLPVIFAANREIPVPKGASMVVTENTEQAADLYITENSVEGDLAITRDIPLAKLLVDKGLYVINDRGTIFTRDNINTYLSARNFMYELQANGLAPEKTNSFGKKEIQKFSNLLDSLLAKALKQRHLDSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KU7</accession>
    <name>Q73KU7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine reductase complex proprotein GrdE2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grdE-2</name>
        <name evidence="3" type="ordered locus">TDE_2120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972721.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674584.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2120"/>
    <dbReference type="EnsemblBacteria" id="AAS12640">
        <property type="protein sequence ID" value="AAS12640"/>
        <property type="gene ID" value="TDE_2120"/>
    </dbReference>
    <dbReference type="GeneID" id="2739379"/>
    <dbReference type="KEGG" id="tde:TDE_2120"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2003"/>
    <dbReference type="eggNOG" id="ENOG502Z7RC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050376_0_0_12"/>
    <dbReference type="OMA" id="EYTPFSK"/>
    <dbReference type="OrthoDB" id="473414at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050485">
        <property type="term" value="F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016585">
        <property type="entry name" value="Gly/sarc/bet_Rdtase_B_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015417">
        <property type="entry name" value="Gly_reductase_pB_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09338">
        <property type="entry name" value="Gly_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011588">
        <property type="entry name" value="Gly_sarc_betain_red_a/b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="1">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Cys)" evidence="2">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR011588-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR011588-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="429" mass="46037" checksum="52DF74EE83968546" modified="2004-07-05" version="1">MKLELGIIPINDMKFGNKTAVNGTCLEVNKAELEALIKEDPLVTGVELHIAKPGDNTRIIPVKDVLEPRCKVEGSGVCFPGFFTGEEAVVGAGKTHVLKGAAVVTTGTVVGFQEGIIDMSGPGAEYTPFSKTVNLVVDCKIQDDVTRAIKEKALRLMGLKTARYLGEAAKNVKPASVETYETLPFVEQAKQYPNLPKVGYVYMLQSQGLLHDTYYYGVDVKQILPTMMYPTEVMDGAIVSGNCVSACDKNPTYVHQNSPIIHELYKRHGKDINFMGVIVTNENVTLADKERSSNLSAKLAQMLGCDAVIVSEEGFGNPDADLIMNCRKIEEMGIKTVLVTDEYAGQDGASQSLADSNPLGNAVVSNGNANAVVKLPPMKTIIGDVKQANVIAGAWDGSLHADGTIEAEIQVITGATNELGFWNLSARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KW5</accession>
    <name>Q73KW5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972703.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2102"/>
    <dbReference type="EnsemblBacteria" id="AAS12622">
        <property type="protein sequence ID" value="AAS12622"/>
        <property type="gene ID" value="TDE_2102"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2102"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1985"/>
    <dbReference type="eggNOG" id="ENOG5031C8C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086381_0_0_12"/>
    <dbReference type="OrthoDB" id="1319581at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="243" mass="27291" checksum="DE1198F060D986D7" modified="2004-07-05" version="1">MEHPAKVQAELSKTETAELEKPKQESENTEPKKELKKEEPKRVVPTKTPGKEVPKKAEPKTIELKKVSEAKESTVPADHVQPAEKPSMGISLADKDKKTFNWSLGLLAEANMNSPEACAMGTGLYTLFMLPLNLKIGHLSLGAKALYSNDFKKHHIFDAALLFRWNFYDFSKIKERDSGFFIQLEGGAVFGLKEREPSKLFMYALGEAAFGYRFTINNFFIEPYLRGGYPVIWAIGISGGFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L10</accession>
    <name>Q73L10_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane hemin-binding protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972658.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679847.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2056"/>
    <dbReference type="EnsemblBacteria" id="AAS12569">
        <property type="protein sequence ID" value="AAS12569"/>
        <property type="gene ID" value="TDE_2056"/>
    </dbReference>
    <dbReference type="GeneID" id="2740650"/>
    <dbReference type="KEGG" id="tde:TDE_2056"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1941"/>
    <dbReference type="eggNOG" id="ENOG5031D9U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694323_0_0_12"/>
    <dbReference type="OrthoDB" id="1703187at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015304">
        <property type="entry name" value="ZinT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09223">
        <property type="entry name" value="ZinT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284920" evidence="2">
        <location>
            <begin position="26"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="ZinT" evidence="3">
        <location>
            <begin position="39"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ZinT" evidence="3">
        <location>
            <begin position="285"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="403" mass="45186" checksum="0610684501A8D437" modified="2004-07-05" version="1">MVNKRMGAKIALILVTLAVIFTACKTMPAAKDNKLAAGMELAAWKGEWVSADIIKNNPSLKAAYKKTAADMRFYTPEGLEAAALDMYKTPAVKAKFDGTNTVLFTYLDKDGKEIQISVKYKYLGQKADGEYPDSMWETFEAVEDKLDNANFKYFISMPPHAHGDGPKHWHARFGKYGIDNLVTGAGRWPTYYSSSTPEAELVKMFESSIPNMPKWNPASPFESYAKYGKWINSLSIFENTSKEVEAAYAKVIKEFAGKNPKGGDFTKAEIIAELQKGNKSVKDYSHMEFIVKDGKNELVFYKGNKEIFRSSYVRVGASPSKPYMTMKAERKDAGMFSLISFVVVHGKAPMLHFHLWYGNNEKEIEEFEGTPTCYRTALTDAEIAAAVEKSARTLLERLTKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L23</accession>
    <name>Q73L23_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972645.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679817.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2042"/>
    <dbReference type="EnsemblBacteria" id="AAS12556">
        <property type="protein sequence ID" value="AAS12556"/>
        <property type="gene ID" value="TDE_2042"/>
    </dbReference>
    <dbReference type="GeneID" id="2740636"/>
    <dbReference type="KEGG" id="tde:TDE_2042"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1927"/>
    <dbReference type="eggNOG" id="ENOG5031CE2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1219256_0_0_12"/>
    <dbReference type="OrthoDB" id="2054766at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284574" evidence="2">
        <location>
            <begin position="21"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="227" mass="26435" checksum="261A917296B344BF" modified="2004-07-05" version="1">MSLKKILCFVFILYSLFIFADGSENSDVQSPPVKETEDQNLPATENKNLSENEKDPEESDKGFYSIQSSGLTACFGDRWFFEQLDDKGRPLISVLYEKDKLIEKKTYTYKDGYPESCEVVLSDKLIKIKYNQKKMETEKIVYDAEGKNELEKNIYTYNENNLLIESFLKKEGTEYISKYEYGPENKIKSKTDFVNGNKISYTEYMTDKKIVHLFEYGKEVGVIEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L54</accession>
    <name>Q73L54_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972614.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679773.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2011"/>
    <dbReference type="EnsemblBacteria" id="AAS12525">
        <property type="protein sequence ID" value="AAS12525"/>
        <property type="gene ID" value="TDE_2011"/>
    </dbReference>
    <dbReference type="GeneID" id="2740358"/>
    <dbReference type="KEGG" id="tde:TDE_2011"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1899"/>
    <dbReference type="eggNOG" id="COG3103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031778_0_1_12"/>
    <dbReference type="OMA" id="MDMTEFL"/>
    <dbReference type="OrthoDB" id="1520094at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285821" evidence="1">
        <location>
            <begin position="31"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="490" mass="54788" checksum="721212C632D5757F" modified="2004-07-05" version="1">MKTIRKYRQAFLLGTIFCMLFFALTFPCGAQEAGGTLSEYQAADNSDDEEFTDDLEDDNGKPVFTVSGKLETAHGLRWNKGAEYSLSRSIAQIKGEVLAGSAYAFLSASAEYNYRNPARTGFKLNEAYFRYSGEIWDLSFGRQLINWGQADGFSLTNVLSAKDSSAFLALSSDDTKLASDSIRLRFFHDIFTFEAVAVPFFTPNKLPRFGFENGAKNDLYHIDTPDTFDMQTPLGTITAPIEYTKTESTKPKMFTDTEAAARLSFFLPGIDFSVSGFYGWDKNPRFTKSGYVKLNAMNLPEKAFITLNQEYYRIGMAGIDAAIPTDDVTIRLESAWIGGRYFEPKNQNPSFGIPNINGVPLTFDPAVCKHQLLALAGLDWIKNSWTLSAQYFEDLILNHKNDIERPIHKGFVSLNISKTFLRDTLKLSASGAVDINYGSTFSTYAVDYSLTDNMHVILGGDLYTKGYDGKGDFAQLNKISSIWVKGRFNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L85</accession>
    <name>Q73L85_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972583.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12494">
        <property type="protein sequence ID" value="AAS12494"/>
        <property type="gene ID" value="TDE_1980"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1980"/>
    <dbReference type="HOGENOM" id="CLU_3384325_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="33" mass="4110" checksum="91F93DA060C03DF4" modified="2004-07-05" version="1">MRSLRLNNALTKLPKLWYNRIKEAFYAYNDYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L88</accession>
    <name>Q73L88_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972580.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1977"/>
    <dbReference type="EnsemblBacteria" id="AAS12491">
        <property type="protein sequence ID" value="AAS12491"/>
        <property type="gene ID" value="TDE_1977"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1977"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1868"/>
    <dbReference type="eggNOG" id="COG0560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035114_0_0_12"/>
    <dbReference type="OMA" id="PYAVFDW"/>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="396" mass="45048" checksum="6316837C98CF42F3" modified="2004-07-05" version="1">MQFIHNAIMLNDDALILKTGNWEPQNKKRLEKLIREKAFNGNYAVFDWDFTSIFYDTQDNLFVYQIENLCFNLNPEEFNQTIRAGIPQDEILPHTINLEGRALTAGELSDDLNERYEFLYKNYLGFSGKMSLAEITLTEEFIDFRAKMLVLMRGAASLCGVDIGQSVSTGMTIEELSVLTEKAIDQGLKDEIKTYRVRSSSVLKGRSGEVEGGYRKGLRVQEEMQDLFSALRKNGIEVYICSASQEDNVRVFASNPKYGYRLDSKNVFGRRRLLDENKKLTVIDNTSIPATRKEGKAEAIKKVLAPKHQNKAPVLIAGDGDGDFYMMDAFKDEALILIFNRSPKKEAKIYPLLMSGIKERENPDARIIVQHRNNQKGCFISKAPEEEKPLDSLPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L93</accession>
    <name>Q73L93_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972575.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1972"/>
    <dbReference type="EnsemblBacteria" id="AAS12486">
        <property type="protein sequence ID" value="AAS12486"/>
        <property type="gene ID" value="TDE_1972"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1972"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1864"/>
    <dbReference type="HOGENOM" id="CLU_3298098_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="40" mass="4419" checksum="CEB96510F143DA25" modified="2004-07-05" version="1">MQKVFIGGMINSSAEIQPHCLSAEFCTYGTKHRIIVCSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LA0</accession>
    <name>Q73LA0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sodium/hydrogen exchanger family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1965</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972568.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679691.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1965"/>
    <dbReference type="EnsemblBacteria" id="AAS12479">
        <property type="protein sequence ID" value="AAS12479"/>
        <property type="gene ID" value="TDE_1965"/>
    </dbReference>
    <dbReference type="GeneID" id="2741528"/>
    <dbReference type="KEGG" id="tde:TDE_1965"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1857"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_7_1_12"/>
    <dbReference type="OMA" id="TTFSHEG"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="21"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="418" mass="44665" checksum="D4C438A1F9BD5DE7" modified="2004-07-05" version="1">MSAGEIPIGEIALQIVLSVGIIVIVAKYLGLLAKKLNIPQVAGEIVAGLLLRYLPFFRNFGGVEPNIIYAETNQFIGYMSEIGVILIMFSAGLGTNLKSLVASGIKSTVIAACGVIVPLVLGTAMALGFWGFDGFGTPVFYQALFIGTILTATSVSITVAALKELGKINSEVGQTIISAAIIDDVLGIIALTVVLGASSGKGDYLALIIKTAAFFAASLVVGYVIYRIFKWYDKRHPHTHRISIYGLGVALIFAYCTERFFGIADITGAYVAGVVLCNLHDASYMEKKIDINSYMFFSPIFFTSIGLKTDFSGLNMSLLWFSIAFVLVGCISKIIGCGGSALTLGFKRKESLQIGLGMMVRGEVALIVAQKGLAVGMVKAEYFAPVILLIIVSSMIVPILLGKAFSDRTFEPPMKEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LA8</accession>
    <name>Q73LA8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972560.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679677.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12471">
        <property type="protein sequence ID" value="AAS12471"/>
        <property type="gene ID" value="TDE_1957"/>
    </dbReference>
    <dbReference type="GeneID" id="2741520"/>
    <dbReference type="KEGG" id="tde:TDE_1957"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1849"/>
    <dbReference type="eggNOG" id="ENOG5031CVI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1266149_0_0_12"/>
    <dbReference type="OrthoDB" id="1361780at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="234" mass="27645" checksum="7506CF919EDD820C" modified="2004-07-05" version="1">MDYEEERKQINCTDEIHQINSKYEDGIIDLKLFQKAKYKILWILKETNGKFSIEHFKNAAELDKGKWKTWKNIAKINSLILDGKQSSKSEQTDYLRQTAIINLNKTFGKSSTKMKIFRKNYLCPENEKTRLIVQKQIKNIRPDIIICGNTLNLLSKQLNFREAIKIEPIPYTKKNNMYCFSNVVFINAYHPCYPTYRPITLSSDKYCEAVVNSVNKWIEWKKTMSLSEFNFDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LA9</accession>
    <name>Q73LA9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972559.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679676.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1956"/>
    <dbReference type="EnsemblBacteria" id="AAS12470">
        <property type="protein sequence ID" value="AAS12470"/>
        <property type="gene ID" value="TDE_1956"/>
    </dbReference>
    <dbReference type="GeneID" id="2741519"/>
    <dbReference type="KEGG" id="tde:TDE_1956"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1848"/>
    <dbReference type="eggNOG" id="ENOG5030UZM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2902981_0_0_12"/>
    <dbReference type="OrthoDB" id="1994428at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="62" mass="6897" checksum="23DE9D1640DD4404" modified="2004-07-05" version="1">MAKEIVYYEVTNSFNGILKGTRFKVTKDSSKHIDACIKEGLAEETGVSTNKINLSMLKCVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LE8</accession>
    <name>Q73LE8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylyltransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972520.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679616.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1917"/>
    <dbReference type="EnsemblBacteria" id="AAS12431">
        <property type="protein sequence ID" value="AAS12431"/>
        <property type="gene ID" value="TDE_1917"/>
    </dbReference>
    <dbReference type="GeneID" id="2740415"/>
    <dbReference type="KEGG" id="tde:TDE_1917"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1814"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015968_0_0_12"/>
    <dbReference type="OMA" id="CLRRIAI"/>
    <dbReference type="OrthoDB" id="263841at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="876" mass="98818" checksum="531DFD42E68DA843" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LF9</accession>
    <name>Q73LF9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972508.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1905"/>
    <dbReference type="EnsemblBacteria" id="AAS12419">
        <property type="protein sequence ID" value="AAS12419"/>
        <property type="gene ID" value="TDE_1905"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1905"/>
    <dbReference type="HOGENOM" id="CLU_3105028_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="51" mass="5903" checksum="D1DCF1690372CD2D" modified="2004-07-05" version="1">MKKIVRLEKDFCNRCSFKTIFAVFAFAAVKSTTAITKMREMCYNITGEDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LK7</accession>
    <name>Q73LK7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972459.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675070.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1855"/>
    <dbReference type="EnsemblBacteria" id="AAS12370">
        <property type="protein sequence ID" value="AAS12370"/>
        <property type="gene ID" value="TDE_1855"/>
    </dbReference>
    <dbReference type="GeneID" id="2740044"/>
    <dbReference type="KEGG" id="tde:TDE_1855"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1760"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184597_0_0_12"/>
    <dbReference type="OrthoDB" id="1347376at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="95" mass="10997" checksum="05D199A3405F9933" modified="2004-07-05" version="1">MRDIEKVNAEIEEVKKELENVHGTGTEVYARIVGYYRSVRNWNKGKREEYNHRLMFSSENERIGKTLSDCDCPPISGSLNFSNSENLSEKKEQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LL2</accession>
    <name>Q73LL2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_1850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972454.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669609.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1850"/>
    <dbReference type="EnsemblBacteria" id="AAS12365">
        <property type="protein sequence ID" value="AAS12365"/>
        <property type="gene ID" value="TDE_1850"/>
    </dbReference>
    <dbReference type="GeneID" id="2740039"/>
    <dbReference type="KEGG" id="tde:TDE_1850"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1755"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_6_12"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="18"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="334"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="444" mass="49489" checksum="608F2799A75DD19F" modified="2004-07-05" version="1">MNILKIAFRNLNRQKRRSILLVFAIAFAFFVVIFMDGMTSGAVNSMAGEISKIVGGHVYIIGSKKAPDKSADDPAQIYMDKNDVEFIEKTVKELGIETTYIIKRSRASGKLIFEGKEVTSQIDGCKFDEEKILHDSILFKEGSWEAMKKENAILLSESVAATLNVDLHDIVLLETRTSQGQLTVIELQVEGIAVNRSSFGGITNYINFDYLQKITELEKDSIEVYSLFLKNPDMQEIYAQQLERKIAETHPITSRDLARTISPSQPASNVFKQLEEGKWQGTKFGIATFYDFAPQVITFMNTLNGISFGILIVLLVITMIGISNTFKIIVYERRGEVGTMRSCGVMRKHIRRLFLAEASFLSLFGAVCGFVLAVLVMQVISFIPIAVDSPFSVFTKNGYFAWNLSALLVFLKFVIMLGLTLLTVRGSASRAANMIPAEALRSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LL8</accession>
    <name>Q73LL8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972448.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1844"/>
    <dbReference type="EnsemblBacteria" id="AAS12359">
        <property type="protein sequence ID" value="AAS12359"/>
        <property type="gene ID" value="TDE_1844"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1844"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1750"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_37_0_12"/>
    <dbReference type="OMA" id="VNCHTFR"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011946">
        <property type="entry name" value="Integrase_integron-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02249">
        <property type="entry name" value="integrase_gron"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="116"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="335" mass="38202" checksum="08F5BD204F62B152" modified="2004-07-05" version="1">MTTEIIGERNNHTATDIQSILNKLEEVITAKHYSKRTMEAYSYWISRFIRENKNKNLKTLSDTEINAFVSRLAVKEKAAASSQNQALAALLFLYKNILGLTIKTPENIVRAKKPKKLPAIMTREETAKIFSLLPENDYGLLIRLLYGTGMRLMEALRLRIQDIDFGKNEITVHCGKGAKDRKTVLPVSLKFPLQKHMEKVRLIHEADCKEGFGSVPLPFALAKKYPNASKAWAWQWVFPQARRWRNKETGEQGRHHIDPSVIQRTLHEAVLRSGIPKPIGCHTFRHSFATHLLEAGYDIRTIQELLGHSDVKTTMVYTHVLNRGGLGIQSPIDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LP8</accession>
    <name>Q73LP8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1792</name>
        <name evidence="3" type="ordered locus">TDE_1814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405</strain>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972396.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972418.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957046.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1792"/>
    <dbReference type="EnsemblBacteria" id="AAS12307">
        <property type="protein sequence ID" value="AAS12307"/>
        <property type="gene ID" value="TDE_1792"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12329">
        <property type="protein sequence ID" value="AAS12329"/>
        <property type="gene ID" value="TDE_1814"/>
    </dbReference>
    <dbReference type="GeneID" id="2741236"/>
    <dbReference type="KEGG" id="tde:TDE_1792"/>
    <dbReference type="KEGG" id="tde:TDE_1814"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1705"/>
    <dbReference type="HOGENOM" id="CLU_946427_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="294" mass="34808" checksum="32160F9A4BB36BFE" modified="2004-07-05" version="1">MNWDNFFFAFSGAAAALIGVTFAFIVSKLLNNISEFDELYNGCQDLLLEFKEQKLNISNIAYDWHDRMILKYEFQIKEKIKNNIFQSFSNEEIVNYIIENVPRVYYPKNCLSYILEEIKKYNDDLETRKIPISPNAFIIQPEILSLPDIPDKDLWKDINEEERNFNKYCQNSYLLIDKFNNYTARMNSKIKDLKIIRNIIAMFIPIIIITVIYPLHFIPIPENEYPQIFFDVSTFLDNLLSLRGFLLFMLFTTISGSLSYFAILCFKYIKKYKEIISFIDNYTDISAYSDLFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LS8</accession>
    <name>Q73LS8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional activator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972388.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957041.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1784"/>
    <dbReference type="EnsemblBacteria" id="AAS12299">
        <property type="protein sequence ID" value="AAS12299"/>
        <property type="gene ID" value="TDE_1784"/>
    </dbReference>
    <dbReference type="GeneID" id="2741228"/>
    <dbReference type="KEGG" id="tde:TDE_1784"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1698"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_1_12"/>
    <dbReference type="OMA" id="HLRRMFS"/>
    <dbReference type="OrthoDB" id="1748122at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="280" mass="32014" checksum="A5774F04414BCADD" modified="2004-07-05" version="1">MNSIQSFNKTIDYIESTLDTEPDEKEIMNLSRYSYPLFSRIFSILVGYPLNEYIRLRKLSRAAADLRNGNEKVIDIALRYGYESPDSFAAAFKKFYGVSPSEVRNGKSFKVFSPVKLSLTVTGGQTMEIRIEKKRAFSIAGLCIQSNQTTDFPKVWNDLFNKASHEELITMGNGQSYGSCYEVKDCNSFNYMAGYDCTDEQKAETFGLSVMHIPEAEYAVVQLKGPVPDCIHQGWKYVMDTFFPEQGYRHAGTPDVEVYKEGDMYDKNYNMELWVPITKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LT8</accession>
    <name>Q73LT8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bleomycin resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bleomycin resistance protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972378.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675091.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1774"/>
    <dbReference type="EnsemblBacteria" id="AAS12289">
        <property type="protein sequence ID" value="AAS12289"/>
        <property type="gene ID" value="TDE_1774"/>
    </dbReference>
    <dbReference type="GeneID" id="2741218"/>
    <dbReference type="KEGG" id="tde:TDE_1774"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_15_0_12"/>
    <dbReference type="OMA" id="LEDCQLM"/>
    <dbReference type="OrthoDB" id="1900922at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08349">
        <property type="entry name" value="BLMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000335">
        <property type="entry name" value="Bleomycin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="129" mass="15462" checksum="62964D4D41F98E4F" modified="2004-07-05" version="1">MKFNSLIPELTVANIEKTREFYVEILQFKIEYERQEDKFIFLSLENNQMMFEQDNGNWNVGILEHPYGRGINFEMTVSNLESLYRRILDFGIKPFREMTVSHYSNGCEKIIQKEFLLQDPDGYLLRFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LZ2</accession>
    <name>Q73LZ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972324.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679436.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1720"/>
    <dbReference type="EnsemblBacteria" id="AAS12235">
        <property type="protein sequence ID" value="AAS12235"/>
        <property type="gene ID" value="TDE_1720"/>
    </dbReference>
    <dbReference type="GeneID" id="2739178"/>
    <dbReference type="KEGG" id="tde:TDE_1720"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1644"/>
    <dbReference type="eggNOG" id="COG4422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1400655_0_0_12"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011101">
        <property type="entry name" value="DUF5131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031010">
        <property type="entry name" value="rSAM_mob_pairA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07505">
        <property type="entry name" value="DUF5131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04471">
        <property type="entry name" value="rSAM_mob_pairA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="229" mass="26737" checksum="AC280F1A8D32F159" modified="2004-07-05" version="1">MSICIKDQIQNMNIVIGCTVGCAYCYARNNVKRWHMIDDFADPEFFPGKLKMMEKKRPQNFLLTGMSDLSGWKLKWRDEVFAKIRENPQHQFLFLTKRPDLLEFDTDLENAWFGVTVTRKAELWRIDALRRNVRAKHYHVTFEPLFDDPGTVGLSGINWIVVGTMTGAQSRKVHTEPEWAWSLTDQAHALGIPVFMKEDLVSIIGDENMIQEMPEEFNKVLEVQRSWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M60</accession>
    <name>Q73M60_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972255.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1649"/>
    <dbReference type="EnsemblBacteria" id="AAS12166">
        <property type="protein sequence ID" value="AAS12166"/>
        <property type="gene ID" value="TDE_1649"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1649"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1575"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110276_0_0_12"/>
    <dbReference type="OMA" id="MELTIFR"/>
    <dbReference type="OrthoDB" id="1984534at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="215" mass="25404" checksum="21C0876B036E80A4" modified="2004-07-05" version="1">MEYKASSYFIHKKGGFNLDIRPLFSYRRGTSFLHRMSPLLKLFFLFGFTAIIFFFPNYVFFYSVFFVFFARFIGFSFLEQLRDLKPILPYCLLLVSLHVFSVLIKTESSIKDLVFLILKLICLMQISSLFFNTTSSLQLKETLEKILPFKLAVLFSLFLFFIPLLFSIWTKLDHSWKARGGKKSLLKIFKLFPIFISEALYKGQKLMYALRNRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M98</accession>
    <name>Q73M98_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972217.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679297.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1611"/>
    <dbReference type="EnsemblBacteria" id="AAS12128">
        <property type="protein sequence ID" value="AAS12128"/>
        <property type="gene ID" value="TDE_1611"/>
    </dbReference>
    <dbReference type="GeneID" id="2740852"/>
    <dbReference type="KEGG" id="tde:TDE_1611"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1540"/>
    <dbReference type="eggNOG" id="COG3663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1271809_0_0_12"/>
    <dbReference type="OMA" id="SEFWKII"/>
    <dbReference type="OrthoDB" id="2034230at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="217" mass="25935" checksum="EE20060173FF34CA" modified="2004-07-05" version="1">MTSKKRPAYNSRKEHVHPFEAYVLENTNTLILGTFPGKKFTDPNKENDKEDWYYGTDRNEFWALIEYALGCKRNSLQTKDEKQKFLTEHKIGITDIIKKARRRQNNNLDINLNVIEITNLDFIIDKCKDIHMIILTSKDMYTRFFIPYYVKKYNAIFKEDKNKEPETHEEKGKKINIYYYTFKGRPIRVVPLHSPARKNVSIKIKKALYKYILKNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MA0</accession>
    <name>Q73MA0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glyco_hydro_114 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972215.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679293.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1609"/>
    <dbReference type="EnsemblBacteria" id="AAS12126">
        <property type="protein sequence ID" value="AAS12126"/>
        <property type="gene ID" value="TDE_1609"/>
    </dbReference>
    <dbReference type="GeneID" id="2740850"/>
    <dbReference type="KEGG" id="tde:TDE_1609"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1538"/>
    <dbReference type="eggNOG" id="COG3868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094223_0_0_12"/>
    <dbReference type="OMA" id="WPDERWI"/>
    <dbReference type="OrthoDB" id="1327691at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_114" evidence="2">
        <location>
            <begin position="45"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="273" mass="31927" checksum="BB0E96FDB6F21D0A" modified="2004-07-05" version="1">MKNTKYLYMVLIFFAIIVIKGMAAENNKEYKVLIGMAPDKAVNLKGIKTLVIDAEFFSKEEIAQLHKNGNVNIFSYLNIGSIETFRDDYEAFKYLALGDYENWDEEKWINVADKRWQKRIKDKARLLSQKGIDGFFLDNADIYYHYKTPEIYRGLMTLLQEIHKKNKPIIINGGDTFISQAMKENALKGIVNGINQESVFTEINFKDNTFGVKPIEDREYFMDYLDKCKTYGFTVYLLEYGPSKKIEKDIKAYCQRNGFIYDISHSLQLYKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MC8</accession>
    <name>Q73MC8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972187.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679252.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1581"/>
    <dbReference type="EnsemblBacteria" id="AAS12098">
        <property type="protein sequence ID" value="AAS12098"/>
        <property type="gene ID" value="TDE_1581"/>
    </dbReference>
    <dbReference type="GeneID" id="2739778"/>
    <dbReference type="KEGG" id="tde:TDE_1581"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1510"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128655_0_0_12"/>
    <dbReference type="OMA" id="EMYNNAF"/>
    <dbReference type="OrthoDB" id="2040551at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019935">
        <property type="entry name" value="CHP03546"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018639">
        <property type="entry name" value="DUF2062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09835">
        <property type="entry name" value="DUF2062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03546">
        <property type="entry name" value="TIGR03546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2062" evidence="2">
        <location>
            <begin position="9"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="172" mass="19444" checksum="BAF585529D191446" modified="2004-07-05" version="1">MIKYVTSFFRAINANAHPGDIAHAVALGLFLAILPKNNLTFTFLFFLSIFIRINKGAFFISFILFGFLTPFMDVLINNIGFWAVQLLFLRPIFIALENIPFVALFKLSNTMVLGGIICGLILYIPVYILTRIIIAKYRKYMQPAVNVKGVGLLGKIPLLRHLTKISDIKDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MD4</accession>
    <name>Q73MD4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972180.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1574"/>
    <dbReference type="EnsemblBacteria" id="AAS12091">
        <property type="protein sequence ID" value="AAS12091"/>
        <property type="gene ID" value="TDE_1574"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1574"/>
    <dbReference type="HOGENOM" id="CLU_3349894_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="37" mass="4612" checksum="CDD1CC9C02F9AAF4" modified="2004-07-05" version="1">MHKCFSLKSIKKFTVRGITRYLDFFMILTYNQKNYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ME6</accession>
    <name>Q73ME6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972168.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679232.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1562"/>
    <dbReference type="EnsemblBacteria" id="AAS12079">
        <property type="protein sequence ID" value="AAS12079"/>
        <property type="gene ID" value="TDE_1562"/>
    </dbReference>
    <dbReference type="GeneID" id="2739312"/>
    <dbReference type="KEGG" id="tde:TDE_1562"/>
    <dbReference type="eggNOG" id="ENOG5031CRT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2182793_0_0_12"/>
    <dbReference type="OrthoDB" id="2150590at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="105" mass="12722" checksum="76B4C2063082368D" modified="2004-07-05" version="1">MKKFGICIVILTIIFTVLDRMNKYWECENFIFNTTMIMNGNYYLVTKEDMKIVEVSALQWYYTNSIASILLVLWILTGLLFLYVMGRHVLPYFWYKKYDHMFDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ME9</accession>
    <name>Q73ME9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972165.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679223.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1559"/>
    <dbReference type="EnsemblBacteria" id="AAS12076">
        <property type="protein sequence ID" value="AAS12076"/>
        <property type="gene ID" value="TDE_1559"/>
    </dbReference>
    <dbReference type="GeneID" id="2739309"/>
    <dbReference type="KEGG" id="tde:TDE_1559"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1495"/>
    <dbReference type="eggNOG" id="ENOG5031FAV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1354101_0_0_12"/>
    <dbReference type="OrthoDB" id="2110886at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="202" mass="23869" checksum="D49492C1E528AB4A" modified="2004-07-05" version="1">MYKNIKKELFLLIIMLIIFILFIMSRCEVNENAVYVKLLSEDTYFDFKEHIAPKEIINEFKRIKGNSLIPSFIHCIAESSDCLLYEDESNIFHIIKIENGQLQDSLYKPKFEYTIDGTYIYFVFEDEFLNYVDRILMCLKLNGQKAGLYPIPISTIILKCEAIIQIEKLSGSTLENIDFEIAYTHYYGENWTLPFKDLYKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MF0</accession>
    <name>Q73MF0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">YD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972164.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956992.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73MF0"/>
    <dbReference type="STRING" id="243275.TDE_1558"/>
    <dbReference type="EnsemblBacteria" id="AAS12075">
        <property type="protein sequence ID" value="AAS12075"/>
        <property type="gene ID" value="TDE_1558"/>
    </dbReference>
    <dbReference type="GeneID" id="2739308"/>
    <dbReference type="KEGG" id="tde:TDE_1558"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1494"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000302_0_0_12"/>
    <dbReference type="OMA" id="DIETRWG"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003284">
        <property type="entry name" value="Sal_SpvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022045">
        <property type="entry name" value="TcdB_toxin_mid/N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03534">
        <property type="entry name" value="SpvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12256">
        <property type="entry name" value="TcdB_toxin_midN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="TcdB_toxin_midN" evidence="5">
        <location>
            <begin position="1878"/>
            <end position="2033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="3320" mass="377978" checksum="20DCBF139415306D" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MG9</accession>
    <name>Q73MG9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972145.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679197.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1539"/>
    <dbReference type="EnsemblBacteria" id="AAS12056">
        <property type="protein sequence ID" value="AAS12056"/>
        <property type="gene ID" value="TDE_1539"/>
    </dbReference>
    <dbReference type="GeneID" id="2740901"/>
    <dbReference type="KEGG" id="tde:TDE_1539"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1476"/>
    <dbReference type="eggNOG" id="ENOG5031CU4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1354110_0_0_12"/>
    <dbReference type="OrthoDB" id="1728743at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="200" mass="23294" checksum="A98086633170EEA9" modified="2004-07-05" version="1">MLKRKKRFLIIFLSVSLLFFLIFGAVELYNYKLGSIKQKLSKTNLSIYSTGTMIKTFGQNTETVSAVISFFTPSGNLINSYERAWQGWELNLECIVFTFESGSIVFPYRLFSNESKYGTGVKLFDYYNRDGYPAIYDYYFFSKEEKELIKSLYGYAVFSPYLLKVFSYAKTKTVSLHNFKPDTEYLLYVGSDGEIRFIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MI5</accession>
    <name>Q73MI5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CitXG protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + apo-[citrate lyase ACP] = diphosphate + holo-[citrate lyase ACP]</text>
            <dbReference type="Rhea" id="RHEA:16333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10157"/>
            <dbReference type="Rhea" id="RHEA-COMP:10158"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61378"/>
            <dbReference type="ChEBI" id="CHEBI:82683"/>
            <dbReference type="EC" id="2.7.7.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3'-dephospho-CoA + ATP = 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine</text>
            <dbReference type="Rhea" id="RHEA:15117"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61378"/>
            <dbReference type="EC" id="2.4.2.52"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972129.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679170.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1523"/>
    <dbReference type="EnsemblBacteria" id="AAS12040">
        <property type="protein sequence ID" value="AAS12040"/>
        <property type="gene ID" value="TDE_1523"/>
    </dbReference>
    <dbReference type="GeneID" id="2739729"/>
    <dbReference type="KEGG" id="tde:TDE_1523"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1462"/>
    <dbReference type="eggNOG" id="COG1767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048409_1_0_12"/>
    <dbReference type="OMA" id="AQNHDFA"/>
    <dbReference type="OrthoDB" id="1738403at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050519">
        <property type="term" value="F:holo-citrate lyase synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046917">
        <property type="term" value="F:triphosphoribosyl-dephospho-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051191">
        <property type="term" value="P:prosthetic group biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002736">
        <property type="entry name" value="CitG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005551">
        <property type="entry name" value="CitX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30201">
        <property type="entry name" value="PTHR30201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01874">
        <property type="entry name" value="CitG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03802">
        <property type="entry name" value="CitX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03124">
        <property type="entry name" value="citrate_citX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="471" mass="53328" checksum="9F17E9DA2FCF1F84" modified="2004-07-05" version="1">MSLSLLEKREKTDFFEKELLNRFPFKTLVVIRANMPGGKKGSIESNWIVYRIFLECKKKMAPLKIFHSYTDEEGLIFFLIVDAPPLEVKALSIKIEDDEALGRLADIDVLTAKKLFSRNDFPHENKRRKCFLCEKDAVICARSRAHSQKEIMNFILKKVHEDWSYDGDIFELLGNLTESSLLAELCRPLGFGCVTANSQGSHKDMDFLLMLKCIPLIGSAIKNLSGKDCESFEALREYGKKQEKKLFDLTGGVNTYKGALFLLLILNACTFRIIKEKKAFTDLSKEIADFSLPLKKDFELKACSPSSLQAFNNLGSGGVRGLALSGFAEHFQNWLPLYKKTFSEGGDFVKIIVKMIETTCDTTIIKRKGEKALLEVQKKAHSLLCIEEGPAQERAIKEFSEWCEKNNISTGGTADKIIILYNLKLIREIFKDLISKTVKMPEISPLVKELTGIITESDLESISYMNRKILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MI9</accession>
    <name>Q73MI9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972125.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679167.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1519"/>
    <dbReference type="EnsemblBacteria" id="AAS12036">
        <property type="protein sequence ID" value="AAS12036"/>
        <property type="gene ID" value="TDE_1519"/>
    </dbReference>
    <dbReference type="GeneID" id="2739725"/>
    <dbReference type="KEGG" id="tde:TDE_1519"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1458"/>
    <dbReference type="eggNOG" id="COG5497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1219100_0_0_12"/>
    <dbReference type="OMA" id="YFMFGEY"/>
    <dbReference type="OrthoDB" id="1752753at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018725">
        <property type="entry name" value="DUF2259_secreted"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10016">
        <property type="entry name" value="DUF2259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284954" evidence="1">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="223" mass="25296" checksum="9DF64F58256F42A4" modified="2004-07-05" version="1">MRKAMISFCFIFCSFFLFAGDIATFVNLGFSADGSKFAFGQYGLTDQTYRAYAEIYGVDVAENKFLPSGRFITSPTSETADKDSKNIFLSLLDRANPSLLRWKISDKNEGRAIYAATDSTINETTLIFKDFETNDEYKVMLYKDKKSNLEASFYIEVEIIKPNGNKIKKAAGQKGKTRSGVRDYAIKKVIIDNTNTSLIFVIEKHQYDKLGNSIRYMVETIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MN3</accession>
    <name>Q73MN3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1475</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the core of the flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Periplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Periplasmic flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972081.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668950.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1475"/>
    <dbReference type="EnsemblBacteria" id="AAS11992">
        <property type="protein sequence ID" value="AAS11992"/>
        <property type="gene ID" value="TDE_1475"/>
    </dbReference>
    <dbReference type="GeneID" id="2741590"/>
    <dbReference type="KEGG" id="tde:TDE_1475"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1415"/>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011142_2_0_12"/>
    <dbReference type="OMA" id="ENEKRMN"/>
    <dbReference type="OrthoDB" id="636786at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3 5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="7">
        <location>
            <begin position="200"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="285" mass="30945" checksum="AE8193E8CCDC718E" modified="2004-07-05" version="1">MIINHNMSAMFAQRQGGVNELHLAKNIEKLSSAQRINRAGDDASGLAVSEKMRSQIRGLNQAGQNIQNGVSFIQATEGYLGETTDIIQRLRELAIQASNGIYSAEDRMQIQVEVSQLVDEVDRIASHAQFNGMNILTGRFAQDSVTGPMQLHVGANMDQREKIYIGTMTATALGIIGAQQGGEDKMISMSSVDGANMALGALDNALKQINKQRADLGAYQNRFEMAYDGIAIAAENMQAAESRIRDADMAKEIVDYTKNQILIQSGTAMLAQANAQPQAVVRLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MP8</accession>
    <name>Q73MP8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972066.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679117.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1460"/>
    <dbReference type="EnsemblBacteria" id="AAS11977">
        <property type="protein sequence ID" value="AAS11977"/>
        <property type="gene ID" value="TDE_1460"/>
    </dbReference>
    <dbReference type="GeneID" id="2741575"/>
    <dbReference type="KEGG" id="tde:TDE_1460"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1401"/>
    <dbReference type="eggNOG" id="ENOG503478X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349808_0_0_12"/>
    <dbReference type="OMA" id="DNTSQNV"/>
    <dbReference type="OrthoDB" id="1540397at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="794" mass="89511" checksum="354182340E79637E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MU9</accession>
    <name>Q73MU9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar filament outer layer protein FlaA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasmic flagellum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972014.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668794.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1408"/>
    <dbReference type="EnsemblBacteria" id="AAS11925">
        <property type="protein sequence ID" value="AAS11925"/>
        <property type="gene ID" value="TDE_1408"/>
    </dbReference>
    <dbReference type="GeneID" id="2741275"/>
    <dbReference type="KEGG" id="tde:TDE_1408"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1350"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OrthoDB" id="820844at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006714">
        <property type="entry name" value="FlaA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04620">
        <property type="entry name" value="FlaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284961" evidence="3">
        <location>
            <begin position="25"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="236" mass="27054" checksum="8A2F0CCFF9A8BF9B" modified="2004-07-05" version="1">MKHGGLVFAGIALMLLFAFAPLTAQQGSINYQTYMVDTFDNPDGQDWAYQAVGSKFITEGYPKVQYLNGMPHAVKVMHDDAENAKFLGLEFKFNRKGDNWVDVVPTKDGKPYEIPFKGNIHRLDMWVWGAGYYYNIEILVRDCEGRTHALPLGYVNFKGWKNMHVTVPTNIPQASRYIGNKNKMTFVAFRIRTAPFERVDSFKIFFDEFKALTDVYVDSYDGYELADQSFDGEKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MV5</accession>
    <name>Q73MV5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972008.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1402"/>
    <dbReference type="EnsemblBacteria" id="AAS11919">
        <property type="protein sequence ID" value="AAS11919"/>
        <property type="gene ID" value="TDE_1402"/>
    </dbReference>
    <dbReference type="GeneID" id="2741269"/>
    <dbReference type="KEGG" id="tde:TDE_1402"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1344"/>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041527_4_1_12"/>
    <dbReference type="OMA" id="ALEIFPI"/>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="25"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="204"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="425" mass="47267" checksum="8122582AB7CA37A6" modified="2004-07-05" version="1">MIKVQNYIPRAVDDKIDLYLTLFGAVCIEGPKWCGKTWSSAYHSKSSFYLGSPQGSFQNRKMAEMTPDIVLLGETPRLIDEWQDVPLLWDAVRFEVDKRGKKGQFILTGSATPNHKGILHSGAGRIGRLRMRPMSLYESKDSTGEVSLKAICEGSSCSSPIKEVSLLDIINLIIRGGWPANVGYSAKNSSKTAAEYLHAILSDDVFRIDGIKRDASKMKLLLKSLARNESSTASNRTLKNDISSIDYEDIDIETTATYLNIFDRLFLTDNQLPFSHNIRSSVRIKQMEKRHLADPSLACALLGAGEKTLLSDLSTLGFLFEALCERDLKVYADTFDASVYHYQDYKNREIDAVIEMKDGSWAAFEIKLGANQIDEAAANLIKIRDSLKAEGAGYPKFMGVICGLANAAYCRKDGVFVIPITSLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N05</accession>
    <name>Q73N05_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rod shape-determining protein MreD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mreD</name>
        <name evidence="9" type="ordered locus">TDE_1351</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971957.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671465.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1351"/>
    <dbReference type="EnsemblBacteria" id="AAS11868">
        <property type="protein sequence ID" value="AAS11868"/>
        <property type="gene ID" value="TDE_1351"/>
    </dbReference>
    <dbReference type="GeneID" id="2739452"/>
    <dbReference type="KEGG" id="tde:TDE_1351"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1299"/>
    <dbReference type="eggNOG" id="COG2891">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132534_2_2_12"/>
    <dbReference type="OMA" id="FFNTRIF"/>
    <dbReference type="OrthoDB" id="1487171at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017225">
        <property type="entry name" value="Cell_shape_determin_MreD_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037497">
        <property type="entry name" value="MreD_Clostridium/Treponema_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="172" mass="19312" checksum="FCD4EAE3270469C0" modified="2004-07-05" version="1">MKKVILWTSLSVFFITLLQTAIFSHISFFTVLPDLVLLTVIYIAISNGSLTGLICGFIAGLLADFLSAAPIGLHSFIFTLTGYLVGKFYGIYNLNKVIFPCILGGLGFVFKVLLLFVLKILFGQNIHTYNIFSINFAIEAAVNIFFTPFVFLFFNLFPQAFISRSIVQYEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N30</accession>
    <name>Q73N30_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971932.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1326"/>
    <dbReference type="EnsemblBacteria" id="AAS11843">
        <property type="protein sequence ID" value="AAS11843"/>
        <property type="gene ID" value="TDE_1326"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1326"/>
    <dbReference type="HOGENOM" id="CLU_3384322_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="33" mass="3826" checksum="8162D978FB4BC12F" modified="2004-07-05" version="1">MLCTKLEDKQRGRIPAELFIISPIKILERNDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NA9</accession>
    <name>Q73NA9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971853.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678738.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1246"/>
    <dbReference type="EnsemblBacteria" id="AAS11764">
        <property type="protein sequence ID" value="AAS11764"/>
        <property type="gene ID" value="TDE_1246"/>
    </dbReference>
    <dbReference type="GeneID" id="2741422"/>
    <dbReference type="KEGG" id="tde:TDE_1246"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1198"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010206_0_0_12"/>
    <dbReference type="OMA" id="WASEAFI"/>
    <dbReference type="OrthoDB" id="1736127at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003368">
        <property type="entry name" value="POMP_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02415">
        <property type="entry name" value="Chlam_PMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Flg_new_2" evidence="4">
        <location>
            <begin position="323"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="842" mass="89673" checksum="1DD4FACF124C9F04" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NE2</accession>
    <name>Q73NE2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal body rod protein FlgB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flgB</name>
        <name evidence="7" type="ordered locus">TDE_1212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971819.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668460.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1212"/>
    <dbReference type="EnsemblBacteria" id="AAS11730">
        <property type="protein sequence ID" value="AAS11730"/>
        <property type="gene ID" value="TDE_1212"/>
    </dbReference>
    <dbReference type="GeneID" id="2740106"/>
    <dbReference type="KEGG" id="tde:TDE_1212"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1167"/>
    <dbReference type="eggNOG" id="COG1815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125463_3_1_12"/>
    <dbReference type="OMA" id="NIQAHHF"/>
    <dbReference type="OrthoDB" id="1914857at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006300">
        <property type="entry name" value="FlgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30435:SF12">
        <property type="entry name" value="PTHR30435:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002889">
        <property type="entry name" value="Rod_FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01396">
        <property type="entry name" value="FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="139" mass="15858" checksum="7AD41FFC78E4D9B3" modified="2004-07-05" version="1">MGFNSFLRTTDILHRALDVNSLRYTVTSNNLANSDVPNFKRTEVNFESELKRAFDSEKNAKGAFQLATTHPLHIKSNEPIDYKTVEPVRVLDYLTAEKANGNNVNPEDEAMKVLKIQMQYQLLSMMAGFQYNQVQSVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NH6</accession>
    <name>Q73NH6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxygen-independent coproporphyrinogen III oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971784.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682426.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1176"/>
    <dbReference type="EnsemblBacteria" id="AAS11695">
        <property type="protein sequence ID" value="AAS11695"/>
        <property type="gene ID" value="TDE_1176"/>
    </dbReference>
    <dbReference type="GeneID" id="2740073"/>
    <dbReference type="KEGG" id="tde:TDE_1176"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1134"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_4_1_12"/>
    <dbReference type="OMA" id="KETRNAY"/>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
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        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
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        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
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        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="43"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="422" mass="47641" checksum="D5A7CBD3CFCE71E0" modified="2004-07-05" version="1">MTAEDILNCSFKDRKKSHHDTGMGSMKYSKGMRSLEKALSEPNTQNGKKSIYIHVPYCKKICNFCSMRRTINPVPDDYAALVIRQIENYGKTEYVKTSNINSVYFGGGTPTTLPAKQLAEILKALQKNFNIAKDAEISMETTVSELDDEKLKILFENGLNRISAGIQTFNDEGRKTLGRIGNGENAENFLRRAFKTGFKNVNIDIIYNYPGETKEILKDDLHKAFALDIAGFSFYSLIVMDTSKIGRSVDKEEYAEKTLHQDAEFFLTILEESRKAGYDFLEITKLVKPGRDNYEYIRSGHLGGDIFPVGAGAGGFVNNTAVMNPLDKEKFADQINGFDKTSGMWISEDYRRIKRFSGQLQEGLLDLSFLTKEESDKIYDMLTGLEKETLIKKDEGSKNYKFTDKGFFWGNSLAAELGKSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NN8</accession>
    <name>Q73NN8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971722.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670670.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1114"/>
    <dbReference type="EnsemblBacteria" id="AAS11603">
        <property type="protein sequence ID" value="AAS11603"/>
        <property type="gene ID" value="TDE_1114"/>
    </dbReference>
    <dbReference type="GeneID" id="2739530"/>
    <dbReference type="KEGG" id="tde:TDE_1114"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1074"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1276555_0_0_12"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="223" mass="25755" checksum="0EF09A5F42979558" modified="2004-07-05" version="1">MPEKDENRESRQEDRESRQNQLIDAATTLFFSKGYTNTSVRDILDEANDRTSSPSVFYYYFESKEAIYRAVLRRYSERYVKSVQDAIDTHKDDAQSLMTQVTRLFLKTVKADAHGKEAAASPDNLLYSLKLKEELTQKFVEVWEIFIRSLDWYKADAETVHKTAVFIAGGIGEMMYDFGYVHEKKEGSARKLMDCMIDFCAGALNAPAAEKEKYRRIVYDNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NU5</accession>
    <name>Q73NU5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1057"/>
    <dbReference type="EnsemblBacteria" id="AAS11546">
        <property type="protein sequence ID" value="AAS11546"/>
        <property type="gene ID" value="TDE_1057"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1057"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1019"/>
    <dbReference type="HOGENOM" id="CLU_3190266_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="46" mass="5302" checksum="F26F754D04971F82" modified="2004-07-05" version="1">MRNCKLGEENPFFGERCFPPLCPLLSPKFRLGAPPLRTRIVIKFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NX0</accession>
    <name>Q73NX0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971640.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010692214.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1032"/>
    <dbReference type="EnsemblBacteria" id="AAS11521">
        <property type="protein sequence ID" value="AAS11521"/>
        <property type="gene ID" value="TDE_1032"/>
    </dbReference>
    <dbReference type="GeneID" id="2741510"/>
    <dbReference type="KEGG" id="tde:TDE_1032"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.992"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_966257_0_0_12"/>
    <dbReference type="OrthoDB" id="2107399at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="287" mass="33465" checksum="40FF106A723BB0C3" modified="2004-07-05" version="1">MSNEQTILNPKTDWVFKLMFSKGEEGNKALISFLNAFLEDSYGKINKAEIINTELIRDRPSGETYRLDFLIRTDNGLIVDLEMQQFWKTNYHRRSQMYLMRLVSRFLKTEPKEDDFLYAISLSVFGCDVPKSAELVKMSESSIIQYLYVELNELIVYTMKKRLEEYSLKDFWIRFLANYEEDKKSGMLEELCRLEEGIKMAEATLFRVTDEERRMAIELSDEKYRMYVEDERSEARREGLAEGRSAGLAEGSYQAKVEVAVSFKRLGVDIDKIAEGTGLSREKIEAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NX6</accession>
    <name>ACP_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name type="ordered locus">TDE_1026</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971634.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670497.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NX6"/>
    <dbReference type="SMR" id="Q73NX6"/>
    <dbReference type="STRING" id="243275.TDE_1026"/>
    <dbReference type="EnsemblBacteria" id="AAS11515">
        <property type="protein sequence ID" value="AAS11515"/>
        <property type="gene ID" value="TDE_1026"/>
    </dbReference>
    <dbReference type="GeneID" id="2741504"/>
    <dbReference type="KEGG" id="tde:TDE_1026"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.988"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_1_12"/>
    <dbReference type="OMA" id="CEIPDEQ"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000066713" description="Acyl carrier protein">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <sequence length="78" mass="9050" checksum="F00BBE466FDBA25E" modified="2004-07-05" version="1">MDDLFKKIQQLIAAKLEIDEDKVTLDSSFRQDLGADSLDTYELVYALEEDMGIKIPDEKANEFETVRDAYEFIKSQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NY1</accession>
    <name>Q73NY1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dicarboxylate transporter, periplasmic dicarboxylate-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971628.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682337.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1020"/>
    <dbReference type="EnsemblBacteria" id="AAS11509">
        <property type="protein sequence ID" value="AAS11509"/>
        <property type="gene ID" value="TDE_1020"/>
    </dbReference>
    <dbReference type="GeneID" id="2741499"/>
    <dbReference type="KEGG" id="tde:TDE_1020"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.981"/>
    <dbReference type="eggNOG" id="COG1638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036176_6_0_12"/>
    <dbReference type="OMA" id="AQMECAF"/>
    <dbReference type="OrthoDB" id="752834at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="342" mass="38812" checksum="52DB07EF62657211" modified="2004-07-05" version="1">MKKKLLFAFFVLVMISGIFAQQKIVLKIASSAPARTPWDIELKKLAQEWNKITKGLVSVRFMDMTVLGGEKAGVVKMKPSRPGQRPQIDGAILSPVGLNELAPNAKIFTLSLPFLIQNQEELDLVLSEYGYAFENEIQKNGCKLITWSNVGWLSFYTKDSYSNLNELKKIKMLCSNDTKDFTDVLKISGFNVLPVDPAKFTQELKAAAGARSFASVSILAYTLRLYKDVSYMLDARLCPIMAGFVMSDESWALIPDQYKPAMLEAMNKTTKNLNAALEDMEREYVKEMKQGGIKIISLNSQQKKEWTKEFQEDMKRVQKTLPNIINAEIYEKITKQLEAYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NZ7</accession>
    <name>Q73NZ7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971612.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11493">
        <property type="protein sequence ID" value="AAS11493"/>
        <property type="gene ID" value="TDE_1003"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1003"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.963"/>
    <dbReference type="HOGENOM" id="CLU_3223405_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="44" mass="5314" checksum="F48F29077E374C9D" modified="2004-07-05" version="1">MNFMSYYTKNYYTKNKKNKQEIKKAVLFRTAFPSNCLQLTLTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P32</accession>
    <name>Q73P32_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971577.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0967"/>
    <dbReference type="EnsemblBacteria" id="AAS11458">
        <property type="protein sequence ID" value="AAS11458"/>
        <property type="gene ID" value="TDE_0967"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0967"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.931"/>
    <dbReference type="eggNOG" id="ENOG5031GYP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184598_0_0_12"/>
    <dbReference type="OMA" id="FEMKESA"/>
    <dbReference type="OrthoDB" id="2012035at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="82" mass="9392" checksum="AB3A27DA342264E3" modified="2004-07-05" version="1">MYTENSTIRRESMKLYSIKTTQGDASYCSILQETDAGYILRICMDKEGYQKVSEDFIEKDLFDMCVRTGYIHELSEAASVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P62</accession>
    <name>Q73P62_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_0937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971547.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670326.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0937"/>
    <dbReference type="EnsemblBacteria" id="AAS11428">
        <property type="protein sequence ID" value="AAS11428"/>
        <property type="gene ID" value="TDE_0937"/>
    </dbReference>
    <dbReference type="GeneID" id="2740970"/>
    <dbReference type="KEGG" id="tde:TDE_0937"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.903"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_5_12"/>
    <dbReference type="OMA" id="MNERPMT"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="286" mass="32719" checksum="44DDACAABBA2B4C7" modified="2004-07-05" version="1">MYNRTKNNYDAEMNSLATYLKEINQIPLLTAEEEIKYAKLAEKGDEDAKNMLVNSNLRFVVNVAKKYQNQGLPLMDLISEGNIGLMNAAERFDVSKGYKFISYAVWWIKQSILKAICEKSRMIRLPLNRANELVQIEKAKKEIDFSGNETKELNEIAGILNMDNSMVHTIMNAAREPISIDAPVFDEPGSSSVNDFLQDETHQMPEDYAMDMSLRDEVNELLKNLDDREAEIIRYRFGLGGYAPLSLKEVGLIFNLTKERIRQIEKKALQQLKKPAEKQKLAVYVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-21" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PB4</accession>
    <name>RL19_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplS</name>
        <name type="ordered locus">TDE_0885</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971495.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670222.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PB4"/>
    <dbReference type="SMR" id="Q73PB4"/>
    <dbReference type="STRING" id="243275.TDE_0885"/>
    <dbReference type="EnsemblBacteria" id="AAS11376">
        <property type="protein sequence ID" value="AAS11376"/>
        <property type="gene ID" value="TDE_0885"/>
    </dbReference>
    <dbReference type="GeneID" id="2739759"/>
    <dbReference type="KEGG" id="tde:TDE_0885"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.855"/>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_2_2_12"/>
    <dbReference type="OMA" id="TITVYYE"/>
    <dbReference type="OrthoDB" id="1698718at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000163560" description="50S ribosomal protein L19">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <sequence length="119" mass="13500" checksum="52B681652B1447F3" modified="2004-07-05" version="1">MSDLIMKIEAQQKAENPPVFRVGDTVKVHFKIVEGKTERIQVYEGLVICFKNSGIGRTFTVRKNSYGVGVERVFPLHSPRIAKVEVVRPGKVRRAKLYYIRDKVGKAAKIKTLITKKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PC6</accession>
    <name>Q73PC6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971483.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670199.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS11364">
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        <property type="gene ID" value="TDE_0873"/>
    </dbReference>
    <dbReference type="GeneID" id="2740920"/>
    <dbReference type="KEGG" id="tde:TDE_0873"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.843"/>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038686_3_0_12"/>
    <dbReference type="OMA" id="YLVMAAM"/>
    <dbReference type="OrthoDB" id="959677at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="258" mass="30521" checksum="80B733F910A57253" modified="2004-07-05" version="1">MSTQTLSHIDTQEVSYSNTEFKVHNFEGPLDLLLFLINKNEVNIYDIPIAEITEQYLEYLDYAIEPDLDNLVDFYSMAANLIYIKSRMLLPVEVSVDDEDIEDPRSELVDKLIEYQKYKKLSELMEEKESEAEWFFERKKIQHALPFGEEELWERVDTWDLLKTFSQLMSNYKAEHILDLYEEVSVNEKITLMNEFLEKKGECMFTDLIVRKGNLMDVVCAFMAILEAVKFKMASIWQNRMFGDIKIRPWEQDNGSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PE3</accession>
    <name>Q73PE3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-fuculose phosphate aldolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971466.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682124.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0856"/>
    <dbReference type="EnsemblBacteria" id="AAS11347">
        <property type="protein sequence ID" value="AAS11347"/>
        <property type="gene ID" value="TDE_0856"/>
    </dbReference>
    <dbReference type="GeneID" id="2741367"/>
    <dbReference type="KEGG" id="tde:TDE_0856"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.825"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_751596_0_0_12"/>
    <dbReference type="OrthoDB" id="1688739at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="8"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="395" mass="43938" checksum="E1F3FE24933CEE99" modified="2004-07-05" version="1">MTLDEAKSIIIETGKRLLTSGLTVRTWGNVSARIDADTFAITPSGYGYENLKPEHIVVLKINRPESSGPVKPSSERFVHASLYKADQNIKFIIHTHQKFASAVSGCFSSIPVENEELHSVLGEAVPVARYAPAGTKRIARHIVKCLTKPVGAIIMAQHGAVCFGADAAEAFAQAEALEDLCRNLIFAEVPALALAYRRYERKALQPLINFYASCREGDSCTVYDKNTDITICKMDIKSGNITEGLFDFQADLHRHIYDTYPDINFIEQSSLPAALFVSKKMNIDNCIPAFLDDFAQIAGENVFLFPFFENRAEEMSTEIVDALKNRSCVLVNESGALCCVSDKNDIGALKEILEKNLLALVLSWKFKNYFPISRRSAQRMRRGYIGGYSKMNLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PE8</accession>
    <name>Q73PE8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971461.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0851"/>
    <dbReference type="EnsemblBacteria" id="AAS11342">
        <property type="protein sequence ID" value="AAS11342"/>
        <property type="gene ID" value="TDE_0851"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0851"/>
    <dbReference type="HOGENOM" id="CLU_2557275_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284621" evidence="1">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="82" mass="8600" checksum="47D33BD66CC94E4D" modified="2004-07-05" version="1">MSITYSVLFSAAFIAASSFLASCLSLISAIPINTEIRPTKAAKIGKPPLKNKRISCPQAKPMGRAAITVKAIKTIPIISASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PG3</accession>
    <name>Q73PG3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)-translocating NADH-quinone reductase, C subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nqrC</name>
        <name evidence="8" type="ordered locus">TDE_0836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971446.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670122.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0836"/>
    <dbReference type="EnsemblBacteria" id="AAS11327">
        <property type="protein sequence ID" value="AAS11327"/>
        <property type="gene ID" value="TDE_0836"/>
    </dbReference>
    <dbReference type="GeneID" id="2739613"/>
    <dbReference type="KEGG" id="tde:TDE_0836"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.805"/>
    <dbReference type="eggNOG" id="COG4659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077882_2_0_12"/>
    <dbReference type="OMA" id="PYIEANQ"/>
    <dbReference type="OrthoDB" id="1381933at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010209">
        <property type="entry name" value="Ion_transpt_RnfG/RsxG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36118">
        <property type="entry name" value="PTHR36118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006091">
        <property type="entry name" value="E_trnsport_RnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284632" evidence="6">
        <location>
            <begin position="24"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="7">
        <location>
            <begin position="94"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="189" mass="20094" checksum="1D75CA3A4A34CC07" modified="2004-07-05" version="1">MKQMIKLALTLSAYAVIACLALAAVYNFTAPRIAEVKIEKTNRALKAVFPEAEDFKEISAEIPEGLNKTTFLNAYTAIKNGKTVGLTITAKGPTYASATILIAMDLNKTIRKIEFLELTDTPSLGSKAADEPFAGQFNGKALDSAFEVNADINAIGGATITSRGVAAIVKDASVTAIEYMAKNNLEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PG8</accession>
    <name>Q73PG8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971441.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0831"/>
    <dbReference type="EnsemblBacteria" id="AAS11322">
        <property type="protein sequence ID" value="AAS11322"/>
        <property type="gene ID" value="TDE_0831"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0831"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.800"/>
    <dbReference type="HOGENOM" id="CLU_2830007_0_0_12"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="66" mass="7778" checksum="85442361791D7DB9" modified="2004-07-05" version="1">MQTEKGKFYDVEMQVSNERNIPKRMRFYQAAIDISFLDKGNSYNNLNDSFIIFIRAEVLIPRRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PH5</accession>
    <name>Q73PH5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971434.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682086.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0824"/>
    <dbReference type="EnsemblBacteria" id="AAS11315">
        <property type="protein sequence ID" value="AAS11315"/>
        <property type="gene ID" value="TDE_0824"/>
    </dbReference>
    <dbReference type="GeneID" id="2739508"/>
    <dbReference type="KEGG" id="tde:TDE_0824"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.794"/>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085385_0_0_12"/>
    <dbReference type="OMA" id="YRTICVI"/>
    <dbReference type="OrthoDB" id="1705869at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP" evidence="1">
        <location>
            <begin position="94"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="216" mass="23936" checksum="E5528E7CB035EF45" modified="2004-07-05" version="1">MKNKLFALWLFAIFILLSSCENLFLGKPKNVHIVNEILTELNRVRSDPKKYAEEELKPRLKYFDGKLYKVPGQIPLQTNEGAPAVQECIDVLINTNPMETLALENGLCLAAQWLADDQANTGKIGHNGSDGSSPFDRMNRYGKWLIKAGKNCAYGTKTGKEIVAQLLIDDGVMNRGHRKNILNPIFKKVGIGYNDEGKAPYGAVSVMDFAGGYVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PS2</accession>
    <name>Q73PS2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TSPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971336.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681962.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0724"/>
    <dbReference type="EnsemblBacteria" id="AAS11217">
        <property type="protein sequence ID" value="AAS11217"/>
        <property type="gene ID" value="TDE_0724"/>
    </dbReference>
    <dbReference type="GeneID" id="2740088"/>
    <dbReference type="KEGG" id="tde:TDE_0724"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.700"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040161_0_0_12"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="TSPc" evidence="2">
        <location>
            <begin position="196"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="434" mass="50348" checksum="6E9C720ACAF61371" modified="2004-07-05" version="1">MKKNIIRIVIAVLIIGTAAFFILFSKYSEEDEQKYKNSYMSKERLEEDYAFVWDFIENGYPFKNVCIRAGADLEKIKKDYFKKLPDIKDELEYYLFYMSLLSKIQNNKHIGHFDVYDVYSLNSDTYRVQNTNVYDNDVKVNSFYYLLLMRMNSAIEQNLSEEILKKYDLNLNPPIDLETEDGLESYFETKIIEDKKIAYLNIKSFYTYNDEIKKAYKKRLNSILTSFKDYENLIIDLRENRGGVRRLWQECIVSPLIKKEQEFCWEVAYNSNNKFTKIFIKDFHSIKLEPNRNFDSFSFSSKNKPDKENFDSICGYTKIIKPLQPSVNFSGKIWLLIGGVTESAADEFASFSKQTKFANVIGENTSGNGLNSSRFYLKLPNSSLLMQSDILYGLNSDGSCNSEAGTAPNIYNLPGKSALGTCLEEIRKLGEKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PV5</accession>
    <name>Q73PV5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0691</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971303.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669937.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0691"/>
    <dbReference type="EnsemblBacteria" id="AAS11184">
        <property type="protein sequence ID" value="AAS11184"/>
        <property type="gene ID" value="TDE_0691"/>
    </dbReference>
    <dbReference type="GeneID" id="2740250"/>
    <dbReference type="KEGG" id="tde:TDE_0691"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.671"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OMA" id="VACKRIM"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="14"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="324"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="356"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="528" mass="59431" checksum="7770E4F3DF709F4A" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PV7</accession>
    <name>Q73PV7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-methyl-5-thioribose kinase</fullName>
            <ecNumber evidence="3">2.7.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthioribose kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.100" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971301.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681910.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0689"/>
    <dbReference type="EnsemblBacteria" id="AAS11182">
        <property type="protein sequence ID" value="AAS11182"/>
        <property type="gene ID" value="TDE_0689"/>
    </dbReference>
    <dbReference type="GeneID" id="2740248"/>
    <dbReference type="KEGG" id="tde:TDE_0689"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.669"/>
    <dbReference type="eggNOG" id="COG4857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033681_0_0_12"/>
    <dbReference type="OMA" id="EMCEITE"/>
    <dbReference type="OrthoDB" id="1457558at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046522">
        <property type="term" value="F:S-methyl-5-thioribose kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009212">
        <property type="entry name" value="Methylthioribose_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031134">
        <property type="entry name" value="MTRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="4">
        <location>
            <begin position="35"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="400" mass="46249" checksum="C7F802F2AFAC9C59" modified="2004-07-05" version="1">MRFSSHYKMEGDDIIDYVFEHSNFFDSNENLVCEEIGDGNINYVYRIFDTNTKKSLILKQADVQTRVRPDGYLNPDRSIREAEVLKLYNECAPDFSPKIIYADPVMAAIIMEDIGSYSNLRTELMAGKIFYGIEELIARFIVDASLPSTDLVLAYQKKFKAAAKFYNPDLCKITEDLVFTHPYKDVRQRNILLPENADWLKKKFYEDSDLIARVAALKEKFNNYPQGLIHGDLHSGSIFVKNKNEEIKIKIIDPEFAFYGPIAYDLGNVLAHFIFAQGYAKYSPLFVDEEKQRTDFLSWLENAKNNLFKFFHIFAKDFLIKNIKDPVYQNEIFIDNYIEKIKIDAVSFCGTELNRRIIGSAKTAEITNIKKIENRIALERDLAELGCAMILNPEEILRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PX7</accession>
    <name>Q73PX7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FeS assembly protein SufD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sufD</name>
        <name evidence="1" type="ordered locus">TDE_0668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971281.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681871.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0668"/>
    <dbReference type="EnsemblBacteria" id="AAS11162">
        <property type="protein sequence ID" value="AAS11162"/>
        <property type="gene ID" value="TDE_0668"/>
    </dbReference>
    <dbReference type="GeneID" id="2739661"/>
    <dbReference type="KEGG" id="tde:TDE_0668"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.649"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_2_0_12"/>
    <dbReference type="OMA" id="QANAWSS"/>
    <dbReference type="OrthoDB" id="422804at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="375" mass="42796" checksum="17409F1C69DB5BD1" modified="2004-07-05" version="1">MSDRTYFKRLDYTKTDIPSKPFCNLNCKASGRAEAKNIEQMTIEQFLKTAPSKDIEKFFDFTKTKREKNCGLGDNYVQEVKDKRNSGIYLKVKKCADNEQAANVLINFTMDQANNVLYDQNLIVIEEGARAKIFFYHDVKAYDCSKADIFRNGLLSIVAEKNSQVEFIKVQNLSHCGINFETVKIFAMEKAQVTLYDIQLGAKINGASTSTYMPEEWAEVQIYPLYFADKTRRIDLEQNFIINGKNSLGAITAKGALKNKAHKMFRGNIFLNRGCSKSIARFSDNTIMLDKTTVGATIPTIFCDEDDVIGEHAASFEAVNKDKLYYLMTRGFDELSAKKLIIEAAFKPVFNRIDDETIREKLLEEFRISLDEIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q31</accession>
    <name>Q73Q31_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971227.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681798.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0613"/>
    <dbReference type="EnsemblBacteria" id="AAS11108">
        <property type="protein sequence ID" value="AAS11108"/>
        <property type="gene ID" value="TDE_0613"/>
    </dbReference>
    <dbReference type="GeneID" id="2739169"/>
    <dbReference type="KEGG" id="tde:TDE_0613"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.592"/>
    <dbReference type="HOGENOM" id="CLU_1937199_0_0_12"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="130" mass="15078" checksum="51C1F258F6FE9C61" modified="2004-07-05" version="1">MSTAKNESPQLKYTGVEINFVINNLEAEHRVIKPSARIKILSIYTFQTLPIYNAISIETAMSTANIAYHIIITSMFSFMLYIKENKITDKEDFFSRKTTYYQTVILPGILSEKYYKQKYSKNAIKSEIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QB7</accession>
    <name>Q73QB7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0526"/>
    <dbReference type="EnsemblBacteria" id="AAS11021">
        <property type="protein sequence ID" value="AAS11021"/>
        <property type="gene ID" value="TDE_0526"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0526"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.512"/>
    <dbReference type="eggNOG" id="ENOG502ZA1U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1093337_0_0_12"/>
    <dbReference type="OrthoDB" id="874949at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="269" mass="31712" checksum="E1C2FCF7AE2993B7" modified="2004-07-05" version="1">MKTVNENLTVEVIMETNNIINGLKHLSEGLFLPEEWIDWWKQNEKIAKQFLSPRWYLKIKPKMSQGLMGAALISQNAAREYLKSINQSYNENSQVNYMEGWRKQIDDISLNCDKVDIIDFDLKFTKLKQSYPNLFAVIKKHLLKSDVVENNLTEEKLTSSFFYKLLHSDVITFFYCISQLKMEGILIDFDMLELREEYIKIGELWLNSDGDELYIRPYEASVYFHDIGKNQIHIINKSFNLFIENDLSRFVYENALPNTFSGFSNQQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QD5</accession>
    <name>Q73QD5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971122.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681638.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0508"/>
    <dbReference type="EnsemblBacteria" id="AAS11003">
        <property type="protein sequence ID" value="AAS11003"/>
        <property type="gene ID" value="TDE_0508"/>
    </dbReference>
    <dbReference type="GeneID" id="2739605"/>
    <dbReference type="KEGG" id="tde:TDE_0508"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.494"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1072635_0_0_12"/>
    <dbReference type="OMA" id="LTINCTQ"/>
    <dbReference type="OrthoDB" id="979016at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="238" mass="27464" checksum="F01AB7E01A84EB7C" modified="2004-07-05" version="1">MNYYNWNAKWAGNSITELKDYTGEEILKLYCYGLSEEKYPLKKDRDNILKSWIDYFNNTKTNIKKLLVTGIVNQELLEAICNQTSLEELVIFQGNFSDIQCIAKLKNLKALSIYASSRVKSLQPIGEIQNLEVLILSNFTGVTDYSPLGKLKNLKQLGIHSSMGNIIKVDSFDFLKSLKNIKNLHTTGFRLLNGDYSPVLELEKLEFLSVNMPAYDYKIWNDRFAEKFKDIPQNDHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QU0</accession>
    <name>Q73QU0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase/acylhydrolase, GDSL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970967.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681336.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0353"/>
    <dbReference type="EnsemblBacteria" id="AAS10848">
        <property type="protein sequence ID" value="AAS10848"/>
        <property type="gene ID" value="TDE_0353"/>
    </dbReference>
    <dbReference type="GeneID" id="2740160"/>
    <dbReference type="KEGG" id="tde:TDE_0353"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.342"/>
    <dbReference type="eggNOG" id="COG1893">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512802_0_0_12"/>
    <dbReference type="OrthoDB" id="427052at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="304"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="531" mass="60286" checksum="00C6599D1C3D2F38" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QY8</accession>
    <name>Q73QY8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">ychF</name>
        <name evidence="6" type="ordered locus">TDE_0305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970919.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666350.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0305"/>
    <dbReference type="EnsemblBacteria" id="AAS10800">
        <property type="protein sequence ID" value="AAS10800"/>
        <property type="gene ID" value="TDE_0305"/>
    </dbReference>
    <dbReference type="GeneID" id="2741026"/>
    <dbReference type="KEGG" id="tde:TDE_0305"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.293"/>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_0_1_12"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="368" mass="40001" checksum="62DF9B6AE6E615B7" modified="2004-07-05" version="1">MAINCGIVGLPNVGKSTIFSALTSAPAEAANYPFCTINPNVGIVSLPDARLKKLAEHFNPKKVIPATVEFVDIAGLVKGASKGEGLGNQFLSHIREVGVIAHVVRCFDNDDIVHVSGKIDPASDIETINIELALADLASLDKRAERAEKASRMGKEAQKEAAVVMRAIEKIRPLLQEGKGARLADLTDDERAAIYDTHLITMKPQMYVCNVDETGAQDSNPYIAAVKKIAESEGADTVVICGKFEAELADLESEEERLSFLAEVGLEESGLSQLARAAYHLIGLRTFFTAGEDECRAWTIHAGDTAPKAAGVIHTDFEKGFIKAEVYSFDDFVKYGSEQKIKEAGRYRQEGKAYVVNDGDIMFFKFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R15</accession>
    <name>Q73R15_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970892.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0278"/>
    <dbReference type="EnsemblBacteria" id="AAS10773">
        <property type="protein sequence ID" value="AAS10773"/>
        <property type="gene ID" value="TDE_0278"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0278"/>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163140_8_0_12"/>
    <dbReference type="OMA" id="EYGRRHE"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="93" mass="10815" checksum="D5CF247EBC56C405" modified="2004-07-05" version="1">MQLDYVVHICYYIYMKTLPVAKVRMNFSALLKEVELGNEIGIAFGRKQETIAVIVPIEEYKRIKARKLGTLEGKVKVEFSEDWTITDEEFINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R64</accession>
    <name>Q73R64_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenine-specific DNA modification methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970843.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681132.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0227"/>
    <dbReference type="REBASE" id="6311">
        <property type="entry name" value="M.TdeII"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10724">
        <property type="protein sequence ID" value="AAS10724"/>
        <property type="gene ID" value="TDE_0227"/>
    </dbReference>
    <dbReference type="GeneID" id="2740781"/>
    <dbReference type="KEGG" id="tde:TDE_0227"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.220"/>
    <dbReference type="eggNOG" id="COG0863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_327867_0_0_12"/>
    <dbReference type="OrthoDB" id="1071106at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="3">
        <location>
            <begin position="324"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="877" mass="103365" checksum="5C0DAE94643281F2" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R73</accession>
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        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">TDE_0218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="42" mass="5375" checksum="ADB3D3655F3DCA24" modified="2004-07-05" version="1">MMDFLEYYHLFSSFFQKKDIDIKRFYKLLQFLLVDNLFIKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RG7</accession>
    <name>Q73RG7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS10619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS10619">
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    </dbReference>
    <dbReference type="GeneID" id="2741736"/>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.121"/>
    <dbReference type="eggNOG" id="COG1368">
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    </dbReference>
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    <dbReference type="OMA" id="HIFIESA"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
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        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
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            <begin position="275"/>
            <end position="473"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="521" mass="59846" checksum="A5CE4F5F4C389BC1" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RH0</accession>
    <name>Q73RH0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.118"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="157" mass="18431" checksum="1DAD8594C146FF39" modified="2004-07-05" version="1">MKQVLSRQEIDQRVAVLKRFKALLQEQRKKFSDYLVVLETQERSINEENIDALVHHTELEQSIIGDIFTIQKVIDPIEEMYRLGMPDKDDTEVVRLKSDLNKLQSQVIDQNQKNRELLQSRMADLRQEMISIKPDYRYSKQALSKQEISASLVDISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RL5</accession>
    <name>Q73RL5_TREDE</name>
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        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="11">Riboflavin kinase</fullName>
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            </recommendedName>
            <alternativeName>
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            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="11">FMN adenylyltransferase</fullName>
                <ecNumber evidence="11">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="11">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="11">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">TDE_0073</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 11">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="11"/>
    <dbReference type="EC" id="2.7.7.2" evidence="11"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970690.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673283.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0073"/>
    <dbReference type="EnsemblBacteria" id="AAS10571">
        <property type="protein sequence ID" value="AAS10571"/>
        <property type="gene ID" value="TDE_0073"/>
    </dbReference>
    <dbReference type="GeneID" id="2741688"/>
    <dbReference type="KEGG" id="tde:TDE_0073"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.74"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_0_2_12"/>
    <dbReference type="OMA" id="HRGHQAI"/>
    <dbReference type="OrthoDB" id="1504821at2"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 11" id="KW-0288">FMN</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="12">
        <location>
            <begin position="167"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS10571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="307" mass="34057" checksum="D14B9A350A12D5C4" modified="2004-07-05" version="1">MRITDKLQPITNGESCVAVGFFDGLHVGHRAVIDRLCKCKNLRPVLISLSNNSSPVIYTEEEKSYLLQNGKLDTMFSLSEDIIKNMTAESFAHDVLNKMLNTKTLVAGENALFGLDQVDVNHFRSIGKKYGFTVETVPMECINGLEVSSNTIKQTIHDGDFSKVSSMLGSSYLISGTVVHGKGAGHKFGMPTANISIAANKLFPPHGVYGSISRFQGENHFGMTNIGLRPSDDDIPIPTIETFLLNFDRDIYGQKVFLELLVYIRGIRKFDGGLAEVRQQIDKDIKQIHSYIEENGNLLQVKPKEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RM6</accession>
    <name>Q73RM6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PTS system, IIA component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970679.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666808.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0062"/>
    <dbReference type="EnsemblBacteria" id="AAS10560">
        <property type="protein sequence ID" value="AAS10560"/>
        <property type="gene ID" value="TDE_0062"/>
    </dbReference>
    <dbReference type="GeneID" id="2741677"/>
    <dbReference type="KEGG" id="tde:TDE_0062"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.63"/>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072531_5_0_12"/>
    <dbReference type="OMA" id="GIDYNSM"/>
    <dbReference type="OrthoDB" id="1810962at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="163" mass="18039" checksum="B1587552A573747A" modified="2004-07-05" version="1">MEFKDALKPDSVDLKDVITPETINLHLKGTTKEAIIDELLDTLVKAGKVKDRVATKACVLDRERKMSTGMKHGIAIPHGKTDSVSDLVACIGIADNPVDFDSLDQEPARIFIMTLSPLDKTGPHLQFLAQISLLFKSAEKREELLRATNEQAVIKLLMESDEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RN1</accession>
    <name>MIAA1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA dimethylallyltransferase 1</fullName>
            <ecNumber evidence="1">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dimethylallyl diphosphate:tRNA dimethylallyltransferase 1</fullName>
            <shortName evidence="1">DMAPP:tRNA dimethylallyltransferase 1</shortName>
            <shortName evidence="1">DMATase 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopentenyl-diphosphate:tRNA isopentenyltransferase 1</fullName>
            <shortName evidence="1">IPP transferase 1</shortName>
            <shortName evidence="1">IPPT 1</shortName>
            <shortName evidence="1">IPTase 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaA1</name>
        <name type="ordered locus">TDE_0057</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970674.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680912.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73RN1"/>
    <dbReference type="SMR" id="Q73RN1"/>
    <dbReference type="STRING" id="243275.TDE_0057"/>
    <dbReference type="EnsemblBacteria" id="AAS10555">
        <property type="protein sequence ID" value="AAS10555"/>
        <property type="gene ID" value="TDE_0057"/>
    </dbReference>
    <dbReference type="GeneID" id="2741672"/>
    <dbReference type="KEGG" id="tde:TDE_0057"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.59"/>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_0_1_12"/>
    <dbReference type="OMA" id="YAKRQYT"/>
    <dbReference type="OrthoDB" id="1069591at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000164000" description="tRNA dimethylallyltransferase 1">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <sequence length="328" mass="37563" checksum="A9E9C92C500E610D" modified="2004-07-05" version="1">MVPVLIFFGATASGKTSLASEIFSYKHSKDFSKEGGISALSACAEIISADSVQVYKHMHIGSASPSKEELEDLPHHLIAIKEPSEEFSAADFVKEADKLCPEIYRRGKLPVLMGGTAFFLKNFLYGLPVTPTADPKIREHFQKRAKEEGAGILLEELKKIDPETAERLHVHDEYRIIRAHEVFAASGKPLSSFALPENPREKYEFFILSIERTRSLLYERIEKRVDAMFAEGLYDEVKKLYEMGYTSESPGLKAIGYREFFDENKRLKPESDLEEVSALIKRNTKHYAKRQETFFKTIPDVHRYFIEDKAEISRLYKDICGFYKKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F7IV85</accession>
    <name>F7IV85_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis protein DmcA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">dmcA</name>
        <name evidence="11" type="ordered locus">TDE_0347</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970961.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681324.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0347"/>
    <dbReference type="EnsemblBacteria" id="AAS10842">
        <property type="protein sequence ID" value="AAS10842"/>
        <property type="gene ID" value="TDE_0347"/>
    </dbReference>
    <dbReference type="GeneID" id="2741243"/>
    <dbReference type="KEGG" id="tde:TDE_0347"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.336"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_12"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="344"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="415"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS10842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="729" mass="80157" checksum="48F6A7DB59EC10A7" modified="2011-07-27" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-10" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>P61339</accession>
    <name>EFTS_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor Ts</fullName>
            <shortName evidence="1">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsf</name>
        <name type="ordered locus">TDE_2346</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972945.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674264.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61339"/>
    <dbReference type="SMR" id="P61339"/>
    <dbReference type="STRING" id="243275.TDE_2346"/>
    <dbReference type="EnsemblBacteria" id="AAS12864">
        <property type="protein sequence ID" value="AAS12864"/>
        <property type="gene ID" value="TDE_2346"/>
    </dbReference>
    <dbReference type="GeneID" id="2739441"/>
    <dbReference type="KEGG" id="tde:TDE_2346"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2214"/>
    <dbReference type="eggNOG" id="COG0264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047155_0_2_12"/>
    <dbReference type="OMA" id="DAGMMDC"/>
    <dbReference type="OrthoDB" id="1405357at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000161224" description="Elongation factor Ts">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="1">
        <location>
            <begin position="79"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <sequence length="280" mass="31131" checksum="0B053D1A9CD73882" modified="2004-05-10" version="1">MDIKASDVKELRDKTGAGMMECKKALQHCNGDAKEAEKYLKEKGLAAVEKRADRVTSEGIIVIKSDHKKAVMLEMTCETDFVAKNADFIAVGEDIAKTAFDKDISEVTPELNDKLLDLATRVRENMNLTRLINVKAGADEYLSRYIHSDKKTGVIIVLKSDKPEIFEKTEVQEFAYDCCLHAAAFMPLYVKKEDVDAAYIKEQEEIFKGQVAELNKPDNVKEGIVKGKISKHLSEICFLEQAFVKDDKLSVSKKMAEVGKEAGGSLSLSKLVIFQLGLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J19</accession>
    <name>Q73J19_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973355.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667001.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2757"/>
    <dbReference type="EnsemblBacteria" id="AAS13274">
        <property type="protein sequence ID" value="AAS13274"/>
        <property type="gene ID" value="TDE_2757"/>
    </dbReference>
    <dbReference type="GeneID" id="2740724"/>
    <dbReference type="KEGG" id="tde:TDE_2757"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_10_1_12"/>
    <dbReference type="OMA" id="YVRQEQT"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="102" mass="12096" checksum="E74B2711D865A77F" modified="2004-07-05" version="1">MKPKEKKEIFNFLEYNKNILQSYGVKKIGLFGSYVHNQQNKNSDIDILVEFHTDKKNYNNFINLVYYLEDNLNTKIDLLTIESLSPYIGQRILNEVEYVSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J41</accession>
    <name>Q73J41_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Surface antigen, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973333.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957306.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2735"/>
    <dbReference type="EnsemblBacteria" id="AAS13252">
        <property type="protein sequence ID" value="AAS13252"/>
        <property type="gene ID" value="TDE_2735"/>
    </dbReference>
    <dbReference type="GeneID" id="2740954"/>
    <dbReference type="KEGG" id="tde:TDE_2735"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2582"/>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053858_0_0_12"/>
    <dbReference type="OrthoDB" id="1739653at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285790" evidence="2">
        <location>
            <begin position="29"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="460" mass="49125" checksum="1BA7B8DD6FB539DA" modified="2004-07-05" version="1">MRQRVKTVLFIGLALIALFGMTACPQRAKPKAEEPAPPPGPQKVTFSVEGTPANGTLKAMAGSTEITSGSKVPYGTTVTFTATVTAAEHYADEWTIKGGSFKTGGKDGDTTATVQITGETEVKVKFSRYKSVAFGTDGADLAAYLNSGTPAADGIYYIKVTGLKAEHLKGNLDMHESSPLAKILQAQPAKKVALKFGKLPAVTDINSCFKDCKNLVSAAAIPKGVTNMESCFYKCEGLTEAPVLPASVTNLCDCFYNCEGLTQAPEIPESVTNMNNCFNGCTNLIQISPFPANAKVTNMNGCFVECESLTQVPALPASVTDITNCFVKCKNLTQAPEIPASVTEMTNCFKECVKLTQAPSAIPKGVTNLYSCFFNCRKLTKAPVIPKSVTYMKYCFKFCGELTEVTLECNYGGEDDFKEAFFSCDKLTAGTIKVPADQVDAYKAGADDMGTQPDRFVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J61</accession>
    <name>Q73J61_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973313.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2715"/>
    <dbReference type="EnsemblBacteria" id="AAS13232">
        <property type="protein sequence ID" value="AAS13232"/>
        <property type="gene ID" value="TDE_2715"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2715"/>
    <dbReference type="HOGENOM" id="CLU_2902978_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="62" mass="6654" checksum="098325DD6FFC6972" modified="2004-07-05" version="1">MLIASYGDADGRAAPASAARAVGACGKDQCCGKYDECGCDERRGSLHFVYSKLHRLLLSKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J68</accession>
    <name>Q73J68_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973306.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13225">
        <property type="protein sequence ID" value="AAS13225"/>
        <property type="gene ID" value="TDE_2708"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2708"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2557"/>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001472_0_0_12"/>
    <dbReference type="OrthoDB" id="12536at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="2120" mass="228317" checksum="97D062140EB41930" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J87</accession>
    <name>Q73J87_TREDE</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2689</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2689"/>
    <dbReference type="EnsemblBacteria" id="AAS13206">
        <property type="protein sequence ID" value="AAS13206"/>
        <property type="gene ID" value="TDE_2689"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2689"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2540"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129794_1_0_12"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="130" mass="15142" checksum="92C391E0870F849F" modified="2004-07-05" version="1">MVKRFEDLTLQDDFMFCKVMQNPDLCKGLIEMILSATIGKIAYISVQHNINTYEQAKSVRFDVLVQTENGKFYDVEMQVSNEKNIPKRIRFYQAAIDISFLDKGNFYNNLNDSFIIFIRAEVLIPRRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JC0</accession>
    <name>Q73JC0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973253.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13172">
        <property type="protein sequence ID" value="AAS13172"/>
        <property type="gene ID" value="TDE_2655"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2655"/>
    <dbReference type="HOGENOM" id="CLU_3367955_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="35" mass="4252" checksum="DF1EE6AF106802D8" modified="2004-07-05" version="1">MRMDSKIKTDENFNSLTGLDFQYKFLRLRECSNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JG5</accession>
    <name>Q73JG5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973208.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2610"/>
    <dbReference type="EnsemblBacteria" id="AAS13127">
        <property type="protein sequence ID" value="AAS13127"/>
        <property type="gene ID" value="TDE_2610"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2610"/>
    <dbReference type="HOGENOM" id="CLU_3334249_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="38" mass="4393" checksum="40A0D7282D975874" modified="2004-07-05" version="1">MLNSKAELIIPHYSIGVFLQVFIHYGGFYRQVLNGYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JI7</accession>
    <name>Q73JI7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bacteriocin ABC transporter, ATP-binding/permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_2431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973030.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2431"/>
    <dbReference type="MEROPS" id="C39.001"/>
    <dbReference type="EnsemblBacteria" id="AAS12949">
        <property type="protein sequence ID" value="AAS12949"/>
        <property type="gene ID" value="TDE_2431"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2431"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2298"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OMA" id="IVGFIRH"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043214">
        <property type="term" value="F:ABC-type bacteriocin transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005897">
        <property type="entry name" value="Pept_C39_ABC_bacteriocin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
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        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01193">
        <property type="entry name" value="bacteriocin_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
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        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
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            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="10">
        <location>
            <begin position="48"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="204"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="517"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="550"/>
            <end position="557"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS12949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="759" mass="84243" checksum="F27CD3934E885F6E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JS1</accession>
    <name>Q73JS1_TREDE</name>
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        <recommendedName>
            <fullName evidence="3">FMN_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973061.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2463"/>
    <dbReference type="EnsemblBacteria" id="AAS12980">
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        <property type="gene ID" value="TDE_2463"/>
    </dbReference>
    <dbReference type="GeneID" id="2739648"/>
    <dbReference type="KEGG" id="tde:TDE_2463"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2330"/>
    <dbReference type="eggNOG" id="ENOG5030VI6">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1325868_0_0_12"/>
    <dbReference type="OrthoDB" id="2116009at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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            <begin position="22"/>
            <end position="207"/>
        </location>
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            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="207" mass="22427" checksum="0E34035EA27DBD69" modified="2004-07-05" version="1">MSKKIKAIGFFVTAILVFAFACEPEMLYGTAKVAGSTPAGTNYEYGYSVCIDVTVDDQGKIIKVSDDEKNTEASIAADVIGAAASNKAYWKKYLSGKGFEKYKNLTIEDVKKMNVGFPGAPGVDAVGGATAASLAVKNAVLQALVLDASLKELVNYKNPDNYKKGEQKKLEKIVKEGRTHLETLETYEEIEKALAELKQKLDALKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JS7</accession>
    <name>Q73JS7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973081.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680450.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2483"/>
    <dbReference type="EnsemblBacteria" id="AAS13000">
        <property type="protein sequence ID" value="AAS13000"/>
        <property type="gene ID" value="TDE_2483"/>
    </dbReference>
    <dbReference type="GeneID" id="2741456"/>
    <dbReference type="KEGG" id="tde:TDE_2483"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2349"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060109_1_0_12"/>
    <dbReference type="OMA" id="SKYQLKF"/>
    <dbReference type="OrthoDB" id="1738788at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS13000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="259" mass="28215" checksum="FBA5DC6016270816" modified="2004-07-05" version="1">MVVKKVICSLIIFFCIGLSSYAEIEKKLLIDEAGVLSQESFSKIEKSLYKISQKSKSETVIVIVPSTGEKSPQDYADDYFDYNGYGQGTESEGSLLLIVTGDGTQGSRYAHISTHGKKTISTLTDNSIEKLLDSLIYGGLKENNYAKGIESYLKALARKFYNSLSLMEILISLGIAVISFAFKFLGTQRKYKNKEAFAFAPFYDIKKNSLVSFETVDDVFLSTNTVSHVIKSNSGGDSGGSSTHTSSSGRTHGGGGRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JV4</accession>
    <name>Q73JV4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973105.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13024">
        <property type="protein sequence ID" value="AAS13024"/>
        <property type="gene ID" value="TDE_2507"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2507"/>
    <dbReference type="HOGENOM" id="CLU_3405982_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3558" checksum="E4AE08BC12BF0D44" modified="2004-07-05" version="1">MYFHDISFLKSTIADYPVKLRICQYESAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JX9</accession>
    <name>Q73JX9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">nth</name>
        <name evidence="13" type="ordered locus">TDE_2534</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973132.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680501.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2534"/>
    <dbReference type="EnsemblBacteria" id="AAS13051">
        <property type="protein sequence ID" value="AAS13051"/>
        <property type="gene ID" value="TDE_2534"/>
    </dbReference>
    <dbReference type="GeneID" id="2739046"/>
    <dbReference type="KEGG" id="tde:TDE_2534"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2397"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_0_12"/>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="12">
        <location>
            <begin position="41"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="11">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS13051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="210" mass="23632" checksum="6EB45CEFEC41584E" modified="2004-07-05" version="1">MNLLDKDKIEEVYRRFKKNNPNPKGELHSANIFTLLVAVVLSAQATDVGVNKATGPFFKAADTPQKMIELGEEGIREYIKTINLYPTKAKRIFELSRIIQNEYSGMVPDSMEELIKLPGVGRKTANVVLNMGFGKPAIAVDTHILRTAPRIGLSLGKTPIQVEEDLLKVTPKKYLLNAHHWILLHGRYICKARKPECETCFLSDICMKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K15</accession>
    <name>Q73K15_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA pseudouridylate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973174.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680560.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2576"/>
    <dbReference type="EnsemblBacteria" id="AAS13093">
        <property type="protein sequence ID" value="AAS13093"/>
        <property type="gene ID" value="TDE_2576"/>
    </dbReference>
    <dbReference type="GeneID" id="2741280"/>
    <dbReference type="KEGG" id="tde:TDE_2576"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2435"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_11_3_12"/>
    <dbReference type="OMA" id="QFEHREV"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="14"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="244" mass="28285" checksum="B471C77761EF7736" modified="2004-07-05" version="1">MKKKLYEILYEDKDILIVNKNAGLLVGADRWDSEAPRLDKILEELYKDKGERKIYPVHRLDKETSGLIIYALNAEAHKTLNDDFQNRKIEKIYHAVSAGIPQEENFKAEEKLRIDGDKLHRTVIDEKKGKESLTEFSLLKRFSRFCLLEARPITGRTHQIRAHLKHLGLPILCDNLYGNGEPVYISALKKNWRGDKYEERPIISRLALHAHSLKFFHPISKEKIEISADYPKDMAGLINQLSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K66</accession>
    <name>Q73K66_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron compound ABC transporter, periplasmic iron compound-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972955.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680274.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2356"/>
    <dbReference type="EnsemblBacteria" id="AAS12874">
        <property type="protein sequence ID" value="AAS12874"/>
        <property type="gene ID" value="TDE_2356"/>
    </dbReference>
    <dbReference type="GeneID" id="2739965"/>
    <dbReference type="KEGG" id="tde:TDE_2356"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2224"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_2_3_12"/>
    <dbReference type="OMA" id="IWKHFNA"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285807" evidence="1">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="48"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="309" mass="34965" checksum="EBD636E46A1354FD" modified="2004-07-05" version="1">MKTKKTLIYFVLVVSLTLFAASCSKINDFFKQDKKDLPDRTTAEAGPRVIAGTMSIVEILDDLGYKNVAGVPSSRHAMPELYAKTEKIGMPMQPDIETVKRLNADIYLASLGSKPTLDKIFQNQNIKTEYVDLNSYEACLNTIRHLGEMTSKQKEAEHVIQTIEAKTLEVRRAIYGKKSPKVLMLLGSPKKLMMGTKNCYTGSLMEVLKIHNIANDIGNFDKSYVPINIEEIVKHQPDVIIRLTHTNSKDTAESLRAEFAKNEIWQKVKAIKEDKIYDLDSNLYTVSRNIKIMQAVENLKEIIYGETED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K70</accession>
    <name>Q73K70_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar hook-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">flgK</name>
        <name evidence="9" type="ordered locus">TDE_2352</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972951.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957216.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2352"/>
    <dbReference type="EnsemblBacteria" id="AAS12870">
        <property type="protein sequence ID" value="AAS12870"/>
        <property type="gene ID" value="TDE_2352"/>
    </dbReference>
    <dbReference type="GeneID" id="2739961"/>
    <dbReference type="KEGG" id="tde:TDE_2352"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2220"/>
    <dbReference type="eggNOG" id="COG1256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012762_1_1_12"/>
    <dbReference type="OMA" id="KPQAAYM"/>
    <dbReference type="OrthoDB" id="1815809at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002371">
        <property type="entry name" value="FlgK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30033">
        <property type="entry name" value="PTHR30033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01005">
        <property type="entry name" value="FLGHOOKAP1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02492">
        <property type="entry name" value="flgK_ends"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flg_bbr_C" evidence="8">
        <location>
            <begin position="573"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="623" mass="69536" checksum="09213C6EFEB888BD" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K75</accession>
    <name>RS2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsB</name>
        <name type="ordered locus">TDE_2347</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972946.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680262.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73K75"/>
    <dbReference type="SMR" id="Q73K75"/>
    <dbReference type="STRING" id="243275.TDE_2347"/>
    <dbReference type="EnsemblBacteria" id="AAS12865">
        <property type="protein sequence ID" value="AAS12865"/>
        <property type="gene ID" value="TDE_2347"/>
    </dbReference>
    <dbReference type="GeneID" id="2739956"/>
    <dbReference type="KEGG" id="tde:TDE_2347"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2215"/>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_1_3_12"/>
    <dbReference type="OMA" id="SYIDRAY"/>
    <dbReference type="OrthoDB" id="1623045at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000134266" description="30S ribosomal protein S2">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="291" mass="32877" checksum="F5A14EAD4D4244BE" modified="2004-07-05" version="1">MAVVTMKNLLESGVHFGHQVKRWDPRMKKYIFSERNGIHIIDLQKTIVAIREAYEAVRKTTSEGKSVLFVGTKKQAQQTIQKEAERCGMFYINNRWLGGMLTNFSTIKKSLARLKKIEKMEVDGTFDNLTKKEIASLQKEKSKLEKNLGGIKEMKDLPGILFIIDTRKEEIAIREARSLGIPIIAVVDTNCNPEGIDYPIPGNDDAIRAISLFTGVIANAVIEADNEHGLKIIENLQEDEESGDSGVDPYQDREEEITDYSNYTPKDEASGDDEDEEDNSLVNDEDLYDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KD4</accession>
    <name>Q73KD4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972884.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680174.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2284"/>
    <dbReference type="EnsemblBacteria" id="AAS12803">
        <property type="protein sequence ID" value="AAS12803"/>
        <property type="gene ID" value="TDE_2284"/>
    </dbReference>
    <dbReference type="GeneID" id="2740034"/>
    <dbReference type="KEGG" id="tde:TDE_2284"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2154"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_2_12"/>
    <dbReference type="OMA" id="IYYESHL"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="3">
        <location>
            <begin position="32"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="52"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="323" mass="36009" checksum="2C10A7EF6EA4FCA0" modified="2004-07-05" version="1">MQDTKQKNKNKKIILMVAAAIIILLIVWILFLPKKGTEEISQTVTVTKEVIQDVIQVSGYIQPAQQQNLHSPGEGLIKKVAVKEGDTVKKGDLIFALDNTYQAFQVAKQEFLIEKEKLQGYSKNLELMKLELESLKRALRDRSVYAKFDGIVVSFDLTEGSYVMPKDNFGVIIDRSFFKSTVDVSEGDVPRLKVGQKVLLSFQALGDEKVEGRVTYHSSIAKSGSQRGATVIETKIVVDKLPENVLPGYSFSGNIIAGEDEEVLLLDQTALSYDKGEPYVERLLENGKIERVNVEVEAYTQGTVKVLSGLKEGDTLRVKPPKW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-06-11" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KI2</accession>
    <name>GLME_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate mutase epsilon subunit</fullName>
            <ecNumber evidence="1">5.4.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamate mutase E chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamate mutase large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Methylaspartate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmE</name>
        <name type="ordered locus">TDE_2236</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3S)-3-methyl-L-aspartate = L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12857"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
            <dbReference type="EC" id="5.4.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylaspartate mutase GlmE subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.1" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972836.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680091.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KI2"/>
    <dbReference type="SMR" id="Q73KI2"/>
    <dbReference type="STRING" id="243275.TDE_2236"/>
    <dbReference type="EnsemblBacteria" id="AAS12755">
        <property type="protein sequence ID" value="AAS12755"/>
        <property type="gene ID" value="TDE_2236"/>
    </dbReference>
    <dbReference type="GeneID" id="2741341"/>
    <dbReference type="KEGG" id="tde:TDE_2236"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2112"/>
    <dbReference type="eggNOG" id="COG4865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029922_0_0_12"/>
    <dbReference type="OMA" id="VIVKTPH"/>
    <dbReference type="OrthoDB" id="809497at2"/>
    <dbReference type="UniPathway" id="UPA00561">
        <property type="reaction ID" value="UER00617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050097">
        <property type="term" value="F:methylaspartate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019670">
        <property type="term" value="P:anaerobic glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019553">
        <property type="term" value="P:glutamate catabolic process via L-citramalate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00245">
        <property type="entry name" value="Glm_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.970.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01923">
        <property type="entry name" value="Me_Asp_mutase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006396">
        <property type="entry name" value="Glu_mut_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014714">
        <property type="entry name" value="Glu_mut_E_C_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06368">
        <property type="entry name" value="Met_asp_mut_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001495">
        <property type="entry name" value="Met_asp_mut_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01503">
        <property type="entry name" value="MthylAspMut_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0846">Cobalamin</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000429446" description="Glutamate mutase epsilon subunit">
        <location>
            <begin position="1"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01923"/>
        </source>
    </evidence>
    <sequence length="485" mass="53131" checksum="9B0EADF05A33BFF7" modified="2004-07-05" version="1">MRWKNKKIPEGEFMEMREEILQTWPTGKDVDLKESIDYLKKIPPEKNFAIKLEQADKEGITTAQPRAGVPLLDEHINLLQFLQDEGGADFLPSTIDAYTRQNRYEEGEAGIEASKKAGRSLMNGFPAVNWGVGPCRQVLEAVNLPLQARHGTPDARLLSEIIHAGGYTSNEGGGISYNVPYAKAVSIEHSIMCWQYADRLVGFYEENGVHLNREPFGPLTGTLVPPSVAIAVGVIEALLAAEQGVKSITVGYGMCGNMTQDVAAVISLREITKDYMKKFGYKDMCITTVFHQWMGGFPADESRAYGLISLGSTTAALSGATKVIVKTPHEAFGIPTKEANAGGIKATKMVLNLLKGQRYPDSRVLAQEIELIKAETKCIMDKVYEIGGGDLVEGTIKAFEAGVIDIPFAPSQYNAGKVMPARDNDGCIRYLMPGNLPFTKDILDFNRGKLEERAKADKREVDFQMSVDDVYAVSSGVLVGRPAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KL9</accession>
    <name>Q73KL9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pyruvate-ferredoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">TDE_2198</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972799.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957178.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2198"/>
    <dbReference type="EnsemblBacteria" id="AAS12718">
        <property type="protein sequence ID" value="AAS12718"/>
        <property type="gene ID" value="TDE_2198"/>
    </dbReference>
    <dbReference type="GeneID" id="2740220"/>
    <dbReference type="KEGG" id="tde:TDE_2198"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2074"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002569_0_0_12"/>
    <dbReference type="OMA" id="YAACINH"/>
    <dbReference type="OrthoDB" id="10483at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037112">
        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019456">
        <property type="entry name" value="Pyrv-flavodox_OxRtase_EKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011895">
        <property type="entry name" value="Pyrv_flavodox_OxRed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000159">
        <property type="entry name" value="NifJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00890">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02176">
        <property type="entry name" value="pyruv_ox_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="680"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="736"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="995"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="1024"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="689"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="692"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="695"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="745"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="751"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="755"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="812"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="815"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="817"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="840"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1104"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAS12718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1201" mass="132688" checksum="B9873EE6FC094882" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KN9</accession>
    <name>Q73KN9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972779.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680025.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2178"/>
    <dbReference type="EnsemblBacteria" id="AAS12698">
        <property type="protein sequence ID" value="AAS12698"/>
        <property type="gene ID" value="TDE_2178"/>
    </dbReference>
    <dbReference type="GeneID" id="2740200"/>
    <dbReference type="KEGG" id="tde:TDE_2178"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2055"/>
    <dbReference type="eggNOG" id="ENOG502Z81F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367908_0_0_12"/>
    <dbReference type="OMA" id="NGVFYDR"/>
    <dbReference type="OrthoDB" id="196838at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="691" mass="76297" checksum="5EC00B9E36E46EC6" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KQ2</accession>
    <name>Q73KQ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase accessory protein HypB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hypB</name>
        <name evidence="3" type="ordered locus">TDE_2165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972766.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680006.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2165"/>
    <dbReference type="EnsemblBacteria" id="AAS12685">
        <property type="protein sequence ID" value="AAS12685"/>
        <property type="gene ID" value="TDE_2165"/>
    </dbReference>
    <dbReference type="GeneID" id="2739151"/>
    <dbReference type="KEGG" id="tde:TDE_2165"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2046"/>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056148_0_1_12"/>
    <dbReference type="OMA" id="ECHLDAH"/>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05390">
        <property type="entry name" value="HypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004392">
        <property type="entry name" value="Hyd_mat_HypB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30134">
        <property type="entry name" value="PTHR30134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00073">
        <property type="entry name" value="hypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="2">
        <location>
            <begin position="36"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="220" mass="24286" checksum="1997200E998C956C" modified="2004-07-05" version="1">MQEFKIIEIKEGVYETNNAHAEKLRKKLKEEKKFLLNLMSSPGSGKTTLLKASIEALKKDFRIGVMEADLDSAVDAETISQTGAKVIQLHTGGMCHLDADMTEQGLEALGIADLDLIFLENIGNLICPAEFDTGALKNVMILSVPEGDDKPLKYPPMFQVCDVLLITKMDASSFFNFSLEKCTGYVKKLNPNIKIFPVSALKGDGMEAWIEWLRSAVKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KQ7</accession>
    <name>Q73KQ7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972761.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2160"/>
    <dbReference type="EnsemblBacteria" id="AAS12680">
        <property type="protein sequence ID" value="AAS12680"/>
        <property type="gene ID" value="TDE_2160"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2160"/>
    <dbReference type="HOGENOM" id="CLU_3399007_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="31" mass="3393" checksum="3BC88F923EA0D8CE" modified="2004-07-05" version="1">MVNSANKFEDAVVLLSLKFSCALCVRCGLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KR8</accession>
    <name>Q73KR8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglycosylase, SLT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972750.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2149"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12669">
        <property type="protein sequence ID" value="AAS12669"/>
        <property type="gene ID" value="TDE_2149"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2149"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2030"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009520_1_0_12"/>
    <dbReference type="OMA" id="EFLFLAM"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="328"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="394"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="442" mass="50947" checksum="A8EEC187C5655FD2" modified="2004-07-05" version="1">MGVGRYLLRRKNLVKTRLFFIVFVFLGFDLIHSASLNFTKDESVKLRQLNKSNLSYNRQKSLHGTVIVSSKYPLIEKFRNQYLNENGLRYLEAIMKRSSPYRNFIIEELRRENLPPELLFLPVIESGFSPKAVSKSGAVGIWQFMRNSIGGYDIHIDEWIDERRDPWKTSTAAVKKLRWNYNYYNDWYLALAAYNCGVGALDKAIKRAGSRNYWYLAEKKFLKTETSLYVAKFLAIAEILMNSEKYGIDWGDALDYEATEIIPIKRSIDVILLAEKVKADTDLFSALNPSLKFNITPPNLKYNLRIPLEYKEAVQDLLEKNTLLIKYYSYKIRSGDTLYALSKHYGVSIKSIMNYNPGINASALKIGQVLKIPALKTVNSYRRKNDDQNLEFKDTYVIKKGDTLWSIALKYDVQVETLAEKNGIEVNSVLSLGQKLKVPIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KR9</accession>
    <name>Q73KR9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972749.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674553.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2148"/>
    <dbReference type="EnsemblBacteria" id="AAS12668">
        <property type="protein sequence ID" value="AAS12668"/>
        <property type="gene ID" value="TDE_2148"/>
    </dbReference>
    <dbReference type="GeneID" id="2739134"/>
    <dbReference type="KEGG" id="tde:TDE_2148"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2029"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609615_0_0_12"/>
    <dbReference type="OMA" id="IEHESIM"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="2">
        <location>
            <begin position="332"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="449" mass="51110" checksum="FC84FAF09AECDA00" modified="2004-07-05" version="1">MNKFLNKNTVLKSAKGLSGFFLFFFLFSFALNAYEPVLQSSSVQNWEKGTIESLIKLDMNKSGFYLPSDRDAAFNTIEKYMPSLLKDIYLSVIVDSSHRLGNYLAEEKVNLNTINKIIEKGNYKNPHFSNDMSNALIKTSTELHEIAKLFIKHNTPYVPSIPPSTTVSKVYTGILIDARGLLPVHGEYTKEKLQPCIFPKVWNTDMSTIYEKNMVDPKIAKKLGIVLYSSSLNEALYREYVGTEPLRIIARGVFGQNRTDPIISMEDSSRILSKPENLKLLQEGRVVIICDEDMLHVTEPFTPPDENYYFAYHDIELLLEKHKEKGIELSNPKNIVKIIMYDIRFVADMPDVLPEEMGKIDVIAEALLKLGPYTKFLIEGHTADLNRPEDEKILSVQRAERIADEISKRGIDRSRIMTAGYGSTRPVAPSNNETNMAKNRRVEITVIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KV6</accession>
    <name>Q73KV6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4340 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972712.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679919.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2111"/>
    <dbReference type="EnsemblBacteria" id="AAS12631">
        <property type="protein sequence ID" value="AAS12631"/>
        <property type="gene ID" value="TDE_2111"/>
    </dbReference>
    <dbReference type="GeneID" id="2740350"/>
    <dbReference type="KEGG" id="tde:TDE_2111"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1994"/>
    <dbReference type="eggNOG" id="ENOG5031CDY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078532_0_0_12"/>
    <dbReference type="OMA" id="CIDIFPA"/>
    <dbReference type="OrthoDB" id="770239at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025641">
        <property type="entry name" value="DUF4340"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14238">
        <property type="entry name" value="DUF4340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4340" evidence="2">
        <location>
            <begin position="87"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="304" mass="35480" checksum="3F71D8278C06298B" modified="2004-07-05" version="1">MKNFFKLKKYTQALIFANIFFLLSLIFVSIPKNEANVFNTSLVSRQNIENIDEIVFTIPDNSLPPRFNELRLIKKKDKFILSSQSGEYKVQPALIERLFSVLSTKQNFRFVSDDIKQYINFGLDEDHAARLQLLRSDKTIMGDFVFGKNDTLGINRYVRIDARTKIFIMPDVLSSFLTVKSNFWLDLQIYKYKFENNSIQLIEKNKQIISRSDKHKEKFDELETFLKQFSCIDIFPAFPITNSETQELNLILGTGEKIEIFFTPMESGDFILFDSASNNSYVISGYTKRRIDSILDSIFEDFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L09</accession>
    <name>Q73L09_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972659.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679849.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2057"/>
    <dbReference type="EnsemblBacteria" id="AAS12570">
        <property type="protein sequence ID" value="AAS12570"/>
        <property type="gene ID" value="TDE_2057"/>
    </dbReference>
    <dbReference type="GeneID" id="2740651"/>
    <dbReference type="KEGG" id="tde:TDE_2057"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1942"/>
    <dbReference type="eggNOG" id="ENOG503282N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208656_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="61" mass="6384" checksum="3E711C98D5376CA1" modified="2004-07-05" version="1">MTLGMVLTISIVAGVILLLIRKYYRIFKGKASACSCGEKNINPKSGCGCGCCGCSAEHKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L24</accession>
    <name>Q73L24_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipoprotein releasing system, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_2041</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972644.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679815.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2041"/>
    <dbReference type="EnsemblBacteria" id="AAS12555">
        <property type="protein sequence ID" value="AAS12555"/>
        <property type="gene ID" value="TDE_2041"/>
    </dbReference>
    <dbReference type="GeneID" id="2740635"/>
    <dbReference type="KEGG" id="tde:TDE_2041"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1926"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_1_12"/>
    <dbReference type="OMA" id="GWWQQNG"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="29"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="294"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="426" mass="47546" checksum="89BE147210074435" modified="2004-07-05" version="1">MKKNNYRWIFFVLNRFNSADTKGRSSISTLFSILGIAFGVMVLTVILSIMNGLQMGYIDTILQVSSGHIRLYGEKEDLKEAENLNLHKAFFIFQESQTLMQGNYGKQHGVLIRSVEEDIMQKDKGLASALKITSGSFNILEKDSVILGYELARQLGVKVGDNVNIIAVSGSSETSLFPENQDLIVTGIFKTGYYEVDSSFAFMSLENGENLFGKESKLYASVKLQNQNNDAAYISSLNASSLNLKAESWRTYNHAFFGALRIEKNMMMLLVILIFLVVSVNIYNGMRRSIYERREEISVLASLGAYSKHIQALFIANGFTIGLIGASAGLLLGLLLSVQINSIFNLIENIVNSVLSFVSILFQNSSDADFSVFSPVYFYMETVPVRIFFNEILLIFLFGIFSSSAAAMIAARRILKLKPAEVLRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L68</accession>
    <name>Q73L68_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972600.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679745.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1997"/>
    <dbReference type="EnsemblBacteria" id="AAS12511">
        <property type="protein sequence ID" value="AAS12511"/>
        <property type="gene ID" value="TDE_1997"/>
    </dbReference>
    <dbReference type="GeneID" id="2740450"/>
    <dbReference type="KEGG" id="tde:TDE_1997"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1885"/>
    <dbReference type="eggNOG" id="ENOG5031CSI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148577_1_0_12"/>
    <dbReference type="OMA" id="IMSTIDI"/>
    <dbReference type="OrthoDB" id="2067715at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="126" mass="14377" checksum="1FBE883DF3BD9586" modified="2004-07-05" version="1">MPKKTTFLSKPEKSKSGQEFRHLRIIVSDSDKNNEQIVVSVTSLKFDNQDTGCIIHPGEHSFIKHKSIVDFKRTKIMSTIDIISGINKGWLIKKEDISDTLLKRIQSALKQSKFISAEVKSLFPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LB0</accession>
    <name>Q73LB0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972558.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679673.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12469">
        <property type="protein sequence ID" value="AAS12469"/>
        <property type="gene ID" value="TDE_1955"/>
    </dbReference>
    <dbReference type="GeneID" id="2741518"/>
    <dbReference type="KEGG" id="tde:TDE_1955"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1847"/>
    <dbReference type="eggNOG" id="ENOG503235Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1175013_0_0_12"/>
    <dbReference type="OrthoDB" id="2157193at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="236" mass="27552" checksum="48BDE3A31A85B29E" modified="2004-07-05" version="1">MNQKDQESRYKITRKNEGDIFIAEIEFSIYEYENLDFVIMYFCYNNQTHNSVEQLIDKYRSNGFETCIIGCIKSLDEVIDYTDDKVYSSFKNLTSKFDLHLDSATDFDFENLIQFCISTEIGNYMSVSPHDMKYRPDTKIQVISVEADTIQNLISVLKTKTNYLFKNNSAKCNRFMISAMTKDKDFEDGTHDYEQICEAFDEYMVEDADCLLAGCTEMPDVFTSEKIKVILIFCDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LC2</accession>
    <name>RS4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsD</name>
        <name type="ordered locus">TDE_1943</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972546.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669771.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73LC2"/>
    <dbReference type="SMR" id="Q73LC2"/>
    <dbReference type="STRING" id="243275.TDE_1943"/>
    <dbReference type="EnsemblBacteria" id="AAS12457">
        <property type="protein sequence ID" value="AAS12457"/>
        <property type="gene ID" value="TDE_1943"/>
    </dbReference>
    <dbReference type="GeneID" id="2740183"/>
    <dbReference type="KEGG" id="tde:TDE_1943"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1835"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_4_12"/>
    <dbReference type="OMA" id="NVVFRMG"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000132485" description="30S ribosomal protein S4">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="95"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="206" mass="23377" checksum="EEB2FFAB22E730EA" modified="2004-07-05" version="1">MAIKQPKGKTVRRLGVNIYGNPKYDKLLDRKPNGPGKERGARKRGKTSVYGEQLKEKQKFRFAYGISERQFRNLYKKASRMPGVTGDNMISLMEQRLDNTIYRMGFAISRAQARQMVTHAYFFINGKPVNIPSMCVSVNDVITTKNKKGIQNLIRHNMSTSQSARGSWLTIDDEKLSATVNILPVTTDIQPVGNIQNVVEYYSRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LD4</accession>
    <name>Q73LD4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Cytidine deaminase</fullName>
            <ecNumber evidence="6 11">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cdd</name>
        <name evidence="13" type="ordered locus">TDE_1931</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 11">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6 11"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972534.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674983.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1931"/>
    <dbReference type="EnsemblBacteria" id="AAS12445">
        <property type="protein sequence ID" value="AAS12445"/>
        <property type="gene ID" value="TDE_1931"/>
    </dbReference>
    <dbReference type="GeneID" id="2740171"/>
    <dbReference type="KEGG" id="tde:TDE_1931"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1826"/>
    <dbReference type="eggNOG" id="COG0295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_0_1_12"/>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="OrthoDB" id="1895660at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS12445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="136" mass="14581" checksum="7AE832886D4CDDBE" modified="2004-07-05" version="1">MEISSQLENLFKTALEAAKKAYAPYSNFHVGAAILLEDGSIVTGVNIENRSYGLTNCAERTAIFKAVSEGKTDFKAIAIATPDADYPVSPCGACRQVISEFMGGDTPVIFGSSLDNVVLTDVKGIYPFDALHELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LG3</accession>
    <name>Q73LG3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972504.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679599.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1901"/>
    <dbReference type="EnsemblBacteria" id="AAS12415">
        <property type="protein sequence ID" value="AAS12415"/>
        <property type="gene ID" value="TDE_1901"/>
    </dbReference>
    <dbReference type="GeneID" id="2740399"/>
    <dbReference type="KEGG" id="tde:TDE_1901"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1800"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="ICGFDVQ"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="282" mass="32136" checksum="0F69968E8AD19EEB" modified="2004-07-05" version="1">MDYILNIKDLNKNYKTFSLKNISFQIPQGTVMGFIGANGAGKTTTIKLIMQLIKKDSGLIEIFGQSAEKNFSSLKQKIGFVYDEPCFYEQLKIKDMTKIIASFYNFWDWKAYKNYLSQFKLDETQKIIQLSKGMKTKYSLALALSHNAQFIIMDEPSSGLDPVIRRELLDIFYDVISDGKCSIFFSTHITSDLERIADYVTFIKNGEVVFSKRKDDIFSEYALVKGGLDELKRGIESKLIGIRKTGVGFEALTKEKQGLPASLIIEKPALEDIMFFYEKASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LH6</accession>
    <name>Q73LH6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972490.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679583.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73LH6"/>
    <dbReference type="STRING" id="243275.TDE_1887"/>
    <dbReference type="EnsemblBacteria" id="AAS12401">
        <property type="protein sequence ID" value="AAS12401"/>
        <property type="gene ID" value="TDE_1887"/>
    </dbReference>
    <dbReference type="GeneID" id="2739116"/>
    <dbReference type="KEGG" id="tde:TDE_1887"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1788"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094983_0_0_12"/>
    <dbReference type="OMA" id="YINLAPE"/>
    <dbReference type="OrthoDB" id="1380982at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="213" mass="24751" checksum="B206CD053AE83ADB" modified="2004-07-05" version="1">MEDKKTKINFIFKFTLVFFMLCWAPLFSQNKPDALVLYKNGRYAEAIAVCEAEIKQSPNNLDSYVVMTWALLADGQYQKTYDMALAGRKIAQTDPRLIATQAEACYYLGKNSEALKLFQDYISYAPNGVRISSSYYFMGEIYLRMAKYRHADISFSVAVTLDSFNSLWWVRLGYAREQIKEYRYSLEAYNKALSLNKNLVDAQKGRERVLQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LK4</accession>
    <name>Q73LK4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, PadR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972462.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669619.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1858"/>
    <dbReference type="EnsemblBacteria" id="AAS12373">
        <property type="protein sequence ID" value="AAS12373"/>
        <property type="gene ID" value="TDE_1858"/>
    </dbReference>
    <dbReference type="GeneID" id="2740047"/>
    <dbReference type="KEGG" id="tde:TDE_1858"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1763"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_3_0_12"/>
    <dbReference type="OMA" id="VSESTMY"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="104" mass="11941" checksum="A9375B9CE4F0E68F" modified="2004-07-05" version="1">MIFSINTGLLEACVLALLKDSDSYGYKLTQDVKSLLPISESTLYPVLKRLQTSGYLETYDQPIDGRNRKYYKITPAGLRQHELYIGEWKSYKELIDKIFKGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LL0</accession>
    <name>Q73LL0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972456.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669611.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1852"/>
    <dbReference type="EnsemblBacteria" id="AAS12367">
        <property type="protein sequence ID" value="AAS12367"/>
        <property type="gene ID" value="TDE_1852"/>
    </dbReference>
    <dbReference type="GeneID" id="2740041"/>
    <dbReference type="KEGG" id="tde:TDE_1852"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1757"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="YSLFPWR"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="250" mass="27954" checksum="B9AF1B301F9BC379" modified="2004-07-05" version="1">MNIVQVKNLKKTYPLGKVLVEAVKGIDFAIEQGEFVSISGPSGSGKSTILNMIGLIDTPSGGELIINNESIYKESDFASLLKKQNKKVKVPNKLDKKMTVLRHEYLGFIFQSFNLVPVLNVYENIEFPLLFGKAKESKANQKEWINYLIDKVGLSEWKNHKSNELSGGQRQRVAIARALATKPQIVLADEPTANLDSKTGIQILELMKEVNRELKTTFIFSTHDAKIVDMTNHRIKILDGQILEDVKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LP7</accession>
    <name>Q73LP7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972419.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957061.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1815"/>
    <dbReference type="EnsemblBacteria" id="AAS12330">
        <property type="protein sequence ID" value="AAS12330"/>
        <property type="gene ID" value="TDE_1815"/>
    </dbReference>
    <dbReference type="GeneID" id="2739245"/>
    <dbReference type="KEGG" id="tde:TDE_1815"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1725"/>
    <dbReference type="HOGENOM" id="CLU_1214341_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="228" mass="26741" checksum="742CA20D6E468EB0" modified="2004-07-05" version="1">MDSTIIGALIGVIGIIIGVLLTYSMSKIMVSTKKKSEYLKKVHLKILSMAEIWFMAETQFRGSHDLKSDYEGSQFISFFKSTLEENIEIIEGDLYQVYIDLKYMDFVEDFSGFMMNLNAIEKLNVVVDELIKENKKLKICKNEIMDRYKKLRNSVNLWIWFSKNIHEVTTINTIMAMKWNFKIPIDEIFADSYFNTVIKPLTDENKILELFKNRYYKEEKDNLTPAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LS4</accession>
    <name>Q73LS4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972392.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957044.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1788"/>
    <dbReference type="EnsemblBacteria" id="AAS12303">
        <property type="protein sequence ID" value="AAS12303"/>
        <property type="gene ID" value="TDE_1788"/>
    </dbReference>
    <dbReference type="GeneID" id="2741232"/>
    <dbReference type="KEGG" id="tde:TDE_1788"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1701"/>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186687_0_0_12"/>
    <dbReference type="OMA" id="MKPINWN"/>
    <dbReference type="OrthoDB" id="1938968at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="95" mass="11542" checksum="3819BEB8AAD3349E" modified="2004-07-05" version="1">MIFDWNNEKNMMLKRDRNISFERIIVAIEQDNLLDILEHPNKEKYPNQLLLLVEIDRYVYVVPCVLENDVCFLKTIFPSRKYTSKYLDWKGEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M08</accession>
    <name>Q73M08_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972307.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678477.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1703"/>
    <dbReference type="EnsemblBacteria" id="AAS12218">
        <property type="protein sequence ID" value="AAS12218"/>
        <property type="gene ID" value="TDE_1703"/>
    </dbReference>
    <dbReference type="GeneID" id="2740875"/>
    <dbReference type="KEGG" id="tde:TDE_1703"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1628"/>
    <dbReference type="eggNOG" id="ENOG5030VCC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122423_0_0_12"/>
    <dbReference type="OrthoDB" id="2113947at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284940" evidence="1">
        <location>
            <begin position="27"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="191" mass="22340" checksum="6500E1CBC25F83E8" modified="2004-07-05" version="1">MLLKTKIDLFKKNLFLCLFLIMGSFAATLNAAEKAEFIINDDPFIFRNKKLIPTEKYTPQELQKKIGKADGSSNKENFIEIFYKDEGVAFLFDNKNYFCGFSFFFMKEDMKPVKIYGLEITKDDTYQSIRKKIKDLNITYNLYEQEGNNHVIDMEFVSKKFGKVNTTIVCSRYEKQNVLLVAILYMDIANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M24</accession>
    <name>Q73M24_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972291.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679393.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1687"/>
    <dbReference type="EnsemblBacteria" id="AAS12202">
        <property type="protein sequence ID" value="AAS12202"/>
        <property type="gene ID" value="TDE_1687"/>
    </dbReference>
    <dbReference type="GeneID" id="2740142"/>
    <dbReference type="KEGG" id="tde:TDE_1687"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1614"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_326228_0_0_12"/>
    <dbReference type="OMA" id="YCIGCAK"/>
    <dbReference type="OrthoDB" id="470724at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="252"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="615"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="760" mass="86981" checksum="4BE4A1BEF23AAC53" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M32</accession>
    <name>RS6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsF</name>
        <name type="ordered locus">TDE_1678</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972283.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669351.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M32"/>
    <dbReference type="SMR" id="Q73M32"/>
    <dbReference type="STRING" id="243275.TDE_1678"/>
    <dbReference type="EnsemblBacteria" id="AAS12194">
        <property type="protein sequence ID" value="AAS12194"/>
        <property type="gene ID" value="TDE_1678"/>
    </dbReference>
    <dbReference type="GeneID" id="2740133"/>
    <dbReference type="KEGG" id="tde:TDE_1678"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1604"/>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113441_5_1_12"/>
    <dbReference type="OMA" id="RYMILVK"/>
    <dbReference type="OrthoDB" id="1776954at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020815">
        <property type="entry name" value="Ribosomal_S6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01048">
        <property type="entry name" value="RIBOSOMAL_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000176866" description="30S ribosomal protein S6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <sequence length="93" mass="10964" checksum="A05B681570AC5E81" modified="2004-07-05" version="1">MRNYELMTVFPVEEDLYKPGIDALHSILADFGVQIKSEEPFGDRDLAYEIKKKTKGRYVLFNIEADPAKMIELDKRFKLITQMLTYLFVRLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M41</accession>
    <name>Q73M41_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972274.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679364.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1669"/>
    <dbReference type="EnsemblBacteria" id="AAS12185">
        <property type="protein sequence ID" value="AAS12185"/>
        <property type="gene ID" value="TDE_1669"/>
    </dbReference>
    <dbReference type="GeneID" id="2739010"/>
    <dbReference type="KEGG" id="tde:TDE_1669"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1595"/>
    <dbReference type="eggNOG" id="COG1168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_15_0_12"/>
    <dbReference type="OMA" id="RINIGCP"/>
    <dbReference type="OrthoDB" id="1462898at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027619">
        <property type="entry name" value="C_S_lyase_PatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04350">
        <property type="entry name" value="C_S_lyase_PatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="32"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="397" mass="46133" checksum="BC76A54F3078CA24" modified="2004-07-05" version="1">MIYDFTTKISRKNLGSLKWDLMYSQNPEVGNEVVPLSVADMEFKNPPELIEGLKKYLDETVLGYTGPTEEYKKTIKKWMKDRHQWDIETDWIINTAGVVPAVFNAVREFTKPGDGVIIITPVYYPFFMAIKNQERKIIECELLEKDGYYTIDFEKLEKLSKDKNNKALLFCSPHNPVGRVWKKDELQKIKDIVLKSDLMLWSDEIHFDLIMPGYEHTVFQSIDEQLADKTITFTAPSKTFNIAGMGMSNIIIKNPDIRERFTKSRDITSGMPFTTLGYKACEICYKECGKWLDDCIKVIDKNQRIVKDFFEVNHPEIKAPLIEGTYLQWIDFRALKMDHKDMEEFMIHKAQIFFDEGYIFGDGGIGFERINLAAPSSVIQESLERLNKALKDLKNRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M43</accession>
    <name>Q73M43_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">eIF-2B alpha/beta/delta-related uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972272.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679362.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1667"/>
    <dbReference type="EnsemblBacteria" id="AAS12183">
        <property type="protein sequence ID" value="AAS12183"/>
        <property type="gene ID" value="TDE_1667"/>
    </dbReference>
    <dbReference type="GeneID" id="2739008"/>
    <dbReference type="KEGG" id="tde:TDE_1667"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1593"/>
    <dbReference type="eggNOG" id="COG0182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_2_0_12"/>
    <dbReference type="OMA" id="DMVTQSA"/>
    <dbReference type="OrthoDB" id="1290468at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="352" mass="38919" checksum="D99B291945330025" modified="2004-07-05" version="1">MREDYNLGFILQYENVAWFDEECGEVRILDRRIYPEKKEFCICKTYVEVAKAIADMVTQSGGPFSAAAMGMALAAYQGKNLSKTAYLEFMKEAAYILSHARPTTSKAMQLVTAESLSLFERLIQSGLSSNEIITSLKQNAVEQNNVRYKKNTAAGSFFADLVPDGSSILTQCFGETTVGGYLRRFKETDKNIKVFCAETRPYFQGARLTASLAYDMGFDTTVITDNMIALLMSEKKINFCVSASDVISLDGSIINKIGTLQIAIAASYFGIPYYAIGFPDKNYVSAKEVKIEYRNPEEALYAMGKRTAILPDDCNLENKSGSISGLYPAFDITPYELCAGIITDKGFFQPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M61</accession>
    <name>Q73M61_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972254.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669263.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1648"/>
    <dbReference type="EnsemblBacteria" id="AAS12165">
        <property type="protein sequence ID" value="AAS12165"/>
        <property type="gene ID" value="TDE_1648"/>
    </dbReference>
    <dbReference type="GeneID" id="2738989"/>
    <dbReference type="KEGG" id="tde:TDE_1648"/>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155761_6_4_12"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="84" mass="10047" checksum="034F2E32456DAA5F" modified="2004-07-05" version="1">MISIRWSRKASKQLNKIQKADKKQILEAVDTLSGFPYVLNVKALSNHKYDYRLRVGRYRILFNHIEKIHILSIEEVKKRDDNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MA5</accession>
    <name>Q73MA5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1604</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972210.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957006.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1604"/>
    <dbReference type="EnsemblBacteria" id="AAS12121">
        <property type="protein sequence ID" value="AAS12121"/>
        <property type="gene ID" value="TDE_1604"/>
    </dbReference>
    <dbReference type="GeneID" id="2740845"/>
    <dbReference type="KEGG" id="tde:TDE_1604"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1533"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076847_2_3_12"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="228" mass="25797" checksum="212A786CB8A3DFEA" modified="2004-07-05" version="1">MKPARNTQGWSMNPITLFILILLTSFLVFLVNQTMYYVLLGMSFLFLFLFSYTEGVKRALAYIGLFLLIKLLAYVDLGMTTGALIGLIALFLRLYPIFNIGRILILTSPLKIMSALRAVKAPQSLSIGLVTALRFLDEMTARLNEIKNGMKVRGLRLSLLHPIRSFELYLIPLIYKCLHVSETLTSSIIAKGIEYEGKKTSYKPVRFGWYDTVGLLAAVFLLWISVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MC1</accession>
    <name>Q73MC1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_1588</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972194.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679267.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1588"/>
    <dbReference type="EnsemblBacteria" id="AAS12105">
        <property type="protein sequence ID" value="AAS12105"/>
        <property type="gene ID" value="TDE_1588"/>
    </dbReference>
    <dbReference type="GeneID" id="2739785"/>
    <dbReference type="KEGG" id="tde:TDE_1588"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1518"/>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_0_1_12"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="OrthoDB" id="951354at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="357" mass="39934" checksum="7F90DF3C71327981" modified="2004-07-05" version="1">MKNIILTGDRPTGKLHIGHYVGSLKNRVALQNSGKYDEIYIMIADAQATTDNADNLEKVRTSVIEVALDYLACGIDPQKSTILVQTQIPELCELTFYYMNLVTLARLERNPTVKNEIKLRGFNTGVNAGGNTGIPVGFLTYPISQAADITAFLANTVPVGEDQMPMIEQTREIVRSFNSLYGETLVEPKELLPANKTCGRLPGTDGKAKMSKSLGNCIYISDSPEEIKKKVMGMFTDPNHLRVEDPGKVEGNPVFAYLDAFARNEHFPEFWSDYSCLNEVKEHYQKGGLGDVKIKKFLNNILQEELRPIREKREAFQKDLPSVYQILIEGTKKAREKAAATTHSVRSAMKINYFEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MD5</accession>
    <name>Q73MD5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-damage-inducible protein J, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972179.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679244.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1573"/>
    <dbReference type="EnsemblBacteria" id="AAS12090">
        <property type="protein sequence ID" value="AAS12090"/>
        <property type="gene ID" value="TDE_1573"/>
    </dbReference>
    <dbReference type="GeneID" id="2739323"/>
    <dbReference type="KEGG" id="tde:TDE_1573"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1503"/>
    <dbReference type="eggNOG" id="COG3077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154558_5_3_12"/>
    <dbReference type="OrthoDB" id="2086657at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007337">
        <property type="entry name" value="RelB/DinJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38781">
        <property type="entry name" value="PTHR38781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04221">
        <property type="entry name" value="RelB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="85" mass="9858" checksum="81FDCD74F22B520D" modified="2004-07-05" version="1">MKTAVLQTRIDKNLKQDADAFFESIGMDTTTAIRIFLKQTLIQRKIPFEIVQDNSFYSEKNIKALEHSKTQMETGQHSIRELVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MP6</accession>
    <name>Q73MP6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sua5/YciO/YrdC/YwlC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972068.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679118.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1462"/>
    <dbReference type="EnsemblBacteria" id="AAS11979">
        <property type="protein sequence ID" value="AAS11979"/>
        <property type="gene ID" value="TDE_1462"/>
    </dbReference>
    <dbReference type="GeneID" id="2741577"/>
    <dbReference type="KEGG" id="tde:TDE_1462"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1403"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_2_12"/>
    <dbReference type="OMA" id="LVDAFWP"/>
    <dbReference type="OrthoDB" id="1913202at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="184" mass="20392" checksum="4EEBC0F3645072CE" modified="2004-07-05" version="1">MVILKKDPKSLETAASVLKKGEIIIVPTDTVYGFSGIMPFTKEKIIKIKKRGAEKSFISLIEKPQDIYKYTDTPVPEILLNLWPAPLSIIVKDKEGRGTSAFRCPDDVWLRNLIGKTGFPIYSTSVNYSGEPVLSDIRDIISEFEDKVSLIVDGGEQKGLSSTIVSLTDKEPCIIRQGALKISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MX1</accession>
    <name>Q73MX1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971991.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11902">
        <property type="protein sequence ID" value="AAS11902"/>
        <property type="gene ID" value="TDE_1385"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1385"/>
    <dbReference type="HOGENOM" id="CLU_3367950_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="35" mass="4352" checksum="C2081A6AD8DD4A29" modified="2004-07-05" version="1">MSDWIIYTEMEMITPDDYLLMMYIFYSKKNRPLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N71</accession>
    <name>Q73N71_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Methyl-accepting chemotaxis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TDE_1284</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971891.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678790.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1284"/>
    <dbReference type="EnsemblBacteria" id="AAS11802">
        <property type="protein sequence ID" value="AAS11802"/>
        <property type="gene ID" value="TDE_1284"/>
    </dbReference>
    <dbReference type="GeneID" id="2741038"/>
    <dbReference type="KEGG" id="tde:TDE_1284"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1234"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_12"/>
    <dbReference type="OMA" id="DMVSTAF"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
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        </location>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50885"/>
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    </evidence>
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            <dbReference type="EMBL" id="AAS11802.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000008212"/>
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    </evidence>
    <sequence length="707" mass="77594" checksum="B128B3924421ECB5" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NB8</accession>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        </location>
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        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="122" mass="14031" checksum="997F9BC5D6E0B282" modified="2004-07-05" version="1">MKKKFFAISIMALLALAVFAQNAANVTTKTQKIEVKDRPSAVMYLTKMDVPGLENQVEFYLTYEENNDTYDEAVCEKIIMEFIAEYKRTNVFSKFEVEDLKAASVGKTKTTVVKRVIFRKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NC0</accession>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        </lineage>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="33" mass="3513" checksum="669389532F709E90" modified="2004-07-05" version="1">MASIIGGSINSSAGIQPHCLSSSFVLRTKHCFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NF2</accession>
    <name>Q73NF2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell cycle protein, FtsW/RodA/SpoVE family</fullName>
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    <gene>
        <name evidence="8" type="ordered locus">TDE_1201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677685.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1201"/>
    <dbReference type="EnsemblBacteria" id="AAS11719">
        <property type="protein sequence ID" value="AAS11719"/>
        <property type="gene ID" value="TDE_1201"/>
    </dbReference>
    <dbReference type="GeneID" id="2741162"/>
    <dbReference type="KEGG" id="tde:TDE_1201"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1156"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="KLWWSNL"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="FtsW"/>
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    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="377" mass="42120" checksum="D4C858568DD0FE2D" modified="2004-07-05" version="1">MVKHIIAKKNIHSEKYDFVFAMSVLLLFGVGFATLYSGSIHYAQRFFDNHLYFVGKQIKHFIAGIIAMTFFLFVDFSTIRKMLPFIMLATFIFCLLPFIPGIGEERNGASRWINIAGFMFQPSELLKLSLILFLANFFDKKNGNYDQPLVSIITPFVIISLFAFLVYLENDFSSSMFIFFIAGLMFFIAGVPILWFIKGFVSFAPIFILMIITKEYRMERVLSFLDPSRSPLDSGFQIQAALNALTSGGVWGQGLGNGLRKIASVPEIYSDFIFVVWAEEMGFIGVVFYIALLAFFAFFGYRIAFGCRSRFGAYVAFGAVSCILSQSLVNCAVVSKMIPATGIPLPFFSSGGSSLVVTFSLCGLILNASGYVNKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NI7</accession>
    <name>Q73NI7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971773.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956911.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1165"/>
    <dbReference type="EnsemblBacteria" id="AAS11654">
        <property type="protein sequence ID" value="AAS11654"/>
        <property type="gene ID" value="TDE_1165"/>
    </dbReference>
    <dbReference type="GeneID" id="2741497"/>
    <dbReference type="KEGG" id="tde:TDE_1165"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1124"/>
    <dbReference type="HOGENOM" id="CLU_2811176_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="69" mass="8104" checksum="4896C68CF0CD5DDF" modified="2004-07-05" version="1">MKTGSNFYATMNEMLDNLNSNIIELKRAYESRNPIKTHTEKLYGLINRNINEARNLLKEDLSLELNKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NI9</accession>
    <name>Q73NI9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971771.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956909.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1163"/>
    <dbReference type="EnsemblBacteria" id="AAS11652">
        <property type="protein sequence ID" value="AAS11652"/>
        <property type="gene ID" value="TDE_1163"/>
    </dbReference>
    <dbReference type="GeneID" id="2741495"/>
    <dbReference type="KEGG" id="tde:TDE_1163"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1122"/>
    <dbReference type="HOGENOM" id="CLU_2653413_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="76" mass="8937" checksum="F723576EA7E970EA" modified="2004-07-05" version="1">MKTIYTVESELLSQRITITETDGKYEIDTEDGVHYSDKEVFLCCFADPRPKFPKRVHRIKKLFDGEVLGIEYLKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NK5</accession>
    <name>Q73NK5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971755.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956894.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1147"/>
    <dbReference type="EnsemblBacteria" id="AAS11636">
        <property type="protein sequence ID" value="AAS11636"/>
        <property type="gene ID" value="TDE_1147"/>
    </dbReference>
    <dbReference type="GeneID" id="2740006"/>
    <dbReference type="KEGG" id="tde:TDE_1147"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1106"/>
    <dbReference type="HOGENOM" id="CLU_1805324_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="143" mass="15834" checksum="5D0A56A3B739563F" modified="2004-07-05" version="1">MAKKNKTKNEVREELKASNPHFTDEQIDELLEESFDGEDTASDETSGGAETGDAAALRAELEAERAELEKEKEALALERAELEKEKAKLDKELTSLNETLDTAITGEEKEYVCNTACTFDGAYYKAGDILVTSKETSEFFDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NL1</accession>
    <name>Q73NL1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tail fiber domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971749.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956888.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1141"/>
    <dbReference type="EnsemblBacteria" id="AAS11630">
        <property type="protein sequence ID" value="AAS11630"/>
        <property type="gene ID" value="TDE_1141"/>
    </dbReference>
    <dbReference type="GeneID" id="2740000"/>
    <dbReference type="KEGG" id="tde:TDE_1141"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1100"/>
    <dbReference type="eggNOG" id="ENOG5031DEJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_516719_0_0_12"/>
    <dbReference type="OrthoDB" id="1705714at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="527" mass="59456" checksum="D1F4A7EEB324D139" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NL7</accession>
    <name>Q73NL7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971743.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956882.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1135"/>
    <dbReference type="EnsemblBacteria" id="AAS11624">
        <property type="protein sequence ID" value="AAS11624"/>
        <property type="gene ID" value="TDE_1135"/>
    </dbReference>
    <dbReference type="GeneID" id="2739994"/>
    <dbReference type="KEGG" id="tde:TDE_1135"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1094"/>
    <dbReference type="eggNOG" id="ENOG5030XHF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2195765_0_0_12"/>
    <dbReference type="OrthoDB" id="2202930at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285864" evidence="2">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="116" mass="13484" checksum="3D6BBEBB6A36C23C" modified="2004-07-05" version="1">MNEKKFFIFMFVCVLLFSLSSCCTRSGIHNHGSRADEVRESVGEVREHQTDAIISNTELGNRIKRGAEISRELNRSIDSSEAIFEEIREIIRRIRKRKHRDDSKERSEDTGKAKED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NM2</accession>
    <name>TRMB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trmB</name>
        <name type="ordered locus">TDE_1130</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971738.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956879.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NM2"/>
    <dbReference type="SMR" id="Q73NM2"/>
    <dbReference type="STRING" id="243275.TDE_1130"/>
    <dbReference type="PRIDE" id="Q73NM2"/>
    <dbReference type="EnsemblBacteria" id="AAS11619">
        <property type="protein sequence ID" value="AAS11619"/>
        <property type="gene ID" value="TDE_1130"/>
    </dbReference>
    <dbReference type="GeneID" id="2739989"/>
    <dbReference type="KEGG" id="tde:TDE_1130"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1091"/>
    <dbReference type="eggNOG" id="COG0220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_0_1_12"/>
    <dbReference type="OMA" id="PDPWHKS"/>
    <dbReference type="OrthoDB" id="1025521at2"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000171415" description="tRNA (guanine-N(7)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="214"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <sequence length="235" mass="27516" checksum="3CDCE9EC15A3EBA7" modified="2004-07-05" version="1">MNSTEITQNTDVPSHFRSIKTFVLRTGRMTEGQKRNYEAFYQKWCIPYTESPIDFQTLFQNDNPVIIEIGFGMGTATAQIAEDNPDKNYLGIEVFKAGVGKLLGEIEEKKLNNLRIIEHDAIEVLENMINNESVDGFHIFFPDPWQKKRNHKRRLVRRPRTDLLSKKLKDGGYIYMVTDWENYAEDAFEQLSETPNLKSKYEKFAPSQSWRPTTKFEKKGLKKEHVINELIFEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NM8</accession>
    <name>Q73NM8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971732.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670690.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1124"/>
    <dbReference type="EnsemblBacteria" id="AAS11613">
        <property type="protein sequence ID" value="AAS11613"/>
        <property type="gene ID" value="TDE_1124"/>
    </dbReference>
    <dbReference type="GeneID" id="2739540"/>
    <dbReference type="KEGG" id="tde:TDE_1124"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1085"/>
    <dbReference type="eggNOG" id="COG2129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095253_0_0_12"/>
    <dbReference type="OMA" id="DPCHRGF"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="225" mass="26106" checksum="87768B3C9CCD8C52" modified="2004-07-05" version="1">MKKILCISDQIDPVIYSKDIKEKYGDVDFIISAGDLPIDYLDFVQNSLNKPLYFVFGSHHLKALTHYHPEMAEKTKDGEVNIFKKGNTKKSNQGTYIGFKSLKYENIIIAGVSGAKKHNDGKNQFTEKQMKRKLSKMIPALFLNKLRYGRYLDILVTHCPPLIEGEKEENKQEAFECFTKFINFFKPKYLIHGQVHIYDPQQCRSIRHGETEIINAYSRHILEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NQ0</accession>
    <name>Q73NQ0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971710.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670643.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1102"/>
    <dbReference type="EnsemblBacteria" id="AAS11591">
        <property type="protein sequence ID" value="AAS11591"/>
        <property type="gene ID" value="TDE_1102"/>
    </dbReference>
    <dbReference type="GeneID" id="2740232"/>
    <dbReference type="KEGG" id="tde:TDE_1102"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1061"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079911_0_0_12"/>
    <dbReference type="OMA" id="LDMRFGK"/>
    <dbReference type="OrthoDB" id="1284752at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="303" mass="35568" checksum="0F3257FC00B0EC8A" modified="2004-07-05" version="1">MKKRIIFFLILLVSFRIFADYKSEYDNLLSARNIKGIAALLPKWEKAEPKNPELYIAYFNYYLLKGQRSTQSLDTYKKDNTNSLALVDQKTNKIAGYLNNNIWYEKEDVDKALSYLEKGLKFGKNRLDMYFGRIHILGEIGEYEKQSQKIIEVLKLGKEINHKWLWSMNEVIPSSESEHFFLISINEYYKNWLQKSSPQTLNAAEKTGEAQLKLYPKNIEVHNYLSLAYIGQGKFKEALNVLLKADKLANEDYVIIFNMGRCYEALKQYDKAKECYLRMKKNPNKQVQDMADQKLSELKKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P37</accession>
    <name>Q73P37_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971572.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0962"/>
    <dbReference type="EnsemblBacteria" id="AAS11453">
        <property type="protein sequence ID" value="AAS11453"/>
        <property type="gene ID" value="TDE_0962"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0962"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.926"/>
    <dbReference type="eggNOG" id="ENOG502ZX8M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422063_0_0_12"/>
    <dbReference type="OMA" id="WENHYLA"/>
    <dbReference type="OrthoDB" id="807179at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="636" mass="73908" checksum="7BE3887EC0F97C2A" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PA0</accession>
    <name>Q73PA0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971509.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682185.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0899"/>
    <dbReference type="EnsemblBacteria" id="AAS11390">
        <property type="protein sequence ID" value="AAS11390"/>
        <property type="gene ID" value="TDE_0899"/>
    </dbReference>
    <dbReference type="GeneID" id="2739939"/>
    <dbReference type="KEGG" id="tde:TDE_0899"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.870"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076847_2_0_12"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="238" mass="27022" checksum="3BC164BCC77914FC" modified="2004-07-05" version="1">MPAENKKYIPDIRVNLFLAVAGSIAVLTYKNEITFIAAFAVSIVFILVQREYKKAFTFVLIFLLLFLFSHLTVGITKLQTLWLFAAVTRHLLIPLSLVSGISDRPPGMLLEVFHRLHLPKGFGISVIVLLRFLPTIKYELKAIRGALKFRGIGISLLNTVFHLPKNFYLTLIPLLIRTVRISDEITAAALTRGIEVNNAIVSFSEVWWTKKDSVALVMLLAGFICLKIIEIKWGWKWR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PE7</accession>
    <name>RL13_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplM</name>
        <name type="ordered locus">TDE_0852</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971462.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682116.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PE7"/>
    <dbReference type="SMR" id="Q73PE7"/>
    <dbReference type="STRING" id="243275.TDE_0852"/>
    <dbReference type="EnsemblBacteria" id="AAS11343">
        <property type="protein sequence ID" value="AAS11343"/>
        <property type="gene ID" value="TDE_0852"/>
    </dbReference>
    <dbReference type="GeneID" id="2741363"/>
    <dbReference type="KEGG" id="tde:TDE_0852"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.821"/>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_2_2_12"/>
    <dbReference type="OMA" id="DFVVIIN"/>
    <dbReference type="OrthoDB" id="1822215at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000055486" description="50S ribosomal protein L13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <sequence length="142" mass="15501" checksum="24F43FED8511677C" modified="2004-07-05" version="1">MKTIFFKEHEAPRSWYLIDAAGKPLGRVAAKTAAMLRGKHKVSFAPHQEIGDYVVIINAEKVAVTGNKAKDKMYYTHSGYVGGLKSINFNGLIAKKPAEPLMIAIKGMLPKGPLGRKLLTNVKVYAGPEHPHQAQNPIAVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PF0</accession>
    <name>Q73PF0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable queuosine precursor transporter</fullName>
            <shortName evidence="1">Q precursor transporter</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971459.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0849"/>
    <dbReference type="EnsemblBacteria" id="AAS11340">
        <property type="protein sequence ID" value="AAS11340"/>
        <property type="gene ID" value="TDE_0849"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0849"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.818"/>
    <dbReference type="eggNOG" id="COG1738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075503_1_2_12"/>
    <dbReference type="OMA" id="IFQKFFY"/>
    <dbReference type="OrthoDB" id="1462872at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990397">
        <property type="term" value="P:queuosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02088">
        <property type="entry name" value="Q_prec_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003744">
        <property type="entry name" value="YhhQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34300">
        <property type="entry name" value="PTHR34300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02592">
        <property type="entry name" value="Vut_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00697">
        <property type="entry name" value="TIGR00697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="216" mass="24428" checksum="554CFFF8F62BF66A" modified="2004-07-05" version="1">MPVISGLFVGVLVLSNILAAKMVQLGPFVFDGGTLLFPFSYIFGDVLAEVYGYKASRKVIWTGFFMLLIMSLNIWLISVLPAEAEWIFQKDFDNILLQMPRICAGSLFGYFIGEYSNSVVLSKLKVITKGKYLWLRTISSTLVGEFLDSAVFVAISFLGLYSIDILIIMAFSNYLFKTFIEVIFTPFTYKIVAFVKKHEQTDVYDYNVSYNPLPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PF1</accession>
    <name>Q73PF1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971458.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0848"/>
    <dbReference type="EnsemblBacteria" id="AAS11339">
        <property type="protein sequence ID" value="AAS11339"/>
        <property type="gene ID" value="TDE_0848"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0848"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.817"/>
    <dbReference type="HOGENOM" id="CLU_2774743_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="69" mass="7680" checksum="32FE9C660D6C08D2" modified="2004-07-05" version="1">MLNVFGTLPPVMSDFSSRILCFMTEQASHTLPLREALPAAISKILMLERYSNNPEFEPDTDPETPPLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PQ4</accession>
    <name>Q73PQ4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">trxB</name>
        <name evidence="6" type="ordered locus">TDE_0743</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971354.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681998.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0743"/>
    <dbReference type="EnsemblBacteria" id="AAS11235">
        <property type="protein sequence ID" value="AAS11235"/>
        <property type="gene ID" value="TDE_0743"/>
    </dbReference>
    <dbReference type="GeneID" id="2740297"/>
    <dbReference type="KEGG" id="tde:TDE_0743"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.718"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_3_12"/>
    <dbReference type="OMA" id="VDNFPGY"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="5"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="317" mass="34216" checksum="CB0E46A5887DF625" modified="2004-07-05" version="1">MSEKYDLVIIGGGPGGMAAGIYAARSKLKTVILEEKPNQGGQCYITEEIENYPGFPESSGPALTEAFKKHAEKFGVEFKRARAEKIELVPNSPTRIVHGSDGVKYECLAVVVATGASARELGCKGEKEHWGKGVSYCATCDGAFFEECEIVVIGGGDSAVEEAMYLTKFADKVTIIHRRDELRAAKSIQEKAFANPKMAFKWNAVVEEVCGEGLVDSVILKDTKTGETSKFDTEGVFVFIGHNPQTAFIQGLVDLDENGYILTNGKMETNVPGIYGVGDVIQKESRQVVTAAADGALAGIWAGHYIDDIKAKMAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PW7</accession>
    <name>Q73PW7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3343 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971291.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681890.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0678"/>
    <dbReference type="EnsemblBacteria" id="AAS11172">
        <property type="protein sequence ID" value="AAS11172"/>
        <property type="gene ID" value="TDE_0678"/>
    </dbReference>
    <dbReference type="GeneID" id="2739671"/>
    <dbReference type="KEGG" id="tde:TDE_0678"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.659"/>
    <dbReference type="eggNOG" id="ENOG5033A63">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167443_2_3_12"/>
    <dbReference type="OrthoDB" id="1844146at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021778">
        <property type="entry name" value="Se/S_carrier-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11823">
        <property type="entry name" value="DUF3343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3343" evidence="1">
        <location>
            <begin position="4"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="114" mass="12175" checksum="B367531DC56D3A3E" modified="2004-07-05" version="1">MKTYGVFSFSSSHHAIAAEAITSGEVMASAEVSDAEALETSGDFSSAASEGLTEARLIPLPPEISAGCGLVLRVNEEGIKMASRLLSEAEIPYTGIYLLKIETNKRFVEKYDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PX4</accession>
    <name>Q73PX4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971284.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669917.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0671"/>
    <dbReference type="EnsemblBacteria" id="AAS11165">
        <property type="protein sequence ID" value="AAS11165"/>
        <property type="gene ID" value="TDE_0671"/>
    </dbReference>
    <dbReference type="GeneID" id="2739664"/>
    <dbReference type="KEGG" id="tde:TDE_0671"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.652"/>
    <dbReference type="eggNOG" id="COG3744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129890_0_1_12"/>
    <dbReference type="OMA" id="FDRMLIC"/>
    <dbReference type="OrthoDB" id="1872329at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09872">
        <property type="entry name" value="PIN_Sll0205-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041705">
        <property type="entry name" value="PIN_Sll0205"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="125" mass="14824" checksum="DCCF4E2132ECF05B" modified="2004-07-05" version="1">MKYFLDTHALLWYLFDSENLSKTAKEIINNEFCYYSKVSLWEIAIKQTRNLLQYKNSIQDIIDACREEEFEELSVSGKSLELIKNLPDIHRDPFDRLLITMAQENNLTIVTKDTKIPLYDVKTVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PZ5</accession>
    <name>Q73PZ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971263.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11144">
        <property type="protein sequence ID" value="AAS11144"/>
        <property type="gene ID" value="TDE_0649"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0649"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.628"/>
    <dbReference type="eggNOG" id="ENOG5032NUE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138603_0_0_12"/>
    <dbReference type="OrthoDB" id="2154204at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="109" mass="12667" checksum="80A9D92C75D3C5F1" modified="2004-07-05" version="1">MAGCYFENDLYVQLDANLTSSRINFFYNGKFQATTGITNYEGTWKHKKNSSFKFQITGKKLIDPSNTIGKSFDSSFEKNLINTDRIEITKNEIKFYAKEGELLLRFIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PZ8</accession>
    <name>Q73PZ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971260.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669891.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0646"/>
    <dbReference type="EnsemblBacteria" id="AAS11141">
        <property type="protein sequence ID" value="AAS11141"/>
        <property type="gene ID" value="TDE_0646"/>
    </dbReference>
    <dbReference type="GeneID" id="2740477"/>
    <dbReference type="KEGG" id="tde:TDE_0646"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.625"/>
    <dbReference type="eggNOG" id="ENOG5032HD6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114980_0_0_12"/>
    <dbReference type="OMA" id="EPSTREY"/>
    <dbReference type="OrthoDB" id="1748602at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="207" mass="23929" checksum="781E1AA00F90C697" modified="2004-07-05" version="1">MNFKEAQTFIIASILAIISFSCSLNYSKEAQNFEKKPNFVFKNAILDQYEENSLNLRINFMELEIYDSDRIWAGKNLRFFKIDKKSFEKGNPEAELKGRAGIIKIDEKNNQYFLGQKVFFEDLKEGLMISGDAFFWNKNENLLYGVEDGSVKVKRGDELYISGSGFIANTLSKEFEFLNSIEGKIQTKNEENENEENSNRNSESQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q07</accession>
    <name>Q73Q07_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971251.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681829.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0637"/>
    <dbReference type="EnsemblBacteria" id="AAS11132">
        <property type="protein sequence ID" value="AAS11132"/>
        <property type="gene ID" value="TDE_0637"/>
    </dbReference>
    <dbReference type="GeneID" id="2739362"/>
    <dbReference type="KEGG" id="tde:TDE_0637"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.615"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_12"/>
    <dbReference type="OMA" id="RVNVMYL"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="332" mass="37453" checksum="F59A5EE955DA7604" modified="2004-07-05" version="1">MKPILQVKDLAVTFKTYAGTIHAVNGISFNLYEDETLVLVGESGCGKSVTAHSILKLLPGKKTRIHEKSQIIFEDKNILEYSEEEMQHIRGNEISMIFQDPLTYLNPTMPIGKQVMESILIHQRLSKKEALERTIKILELAQIPDPEKRLRQYPHEFSGGMRQRVLISIALASNPKILIADEPTTALDVTIQAEILELIQKIQKETKTAVMLITHDLGVAAEIADRIQVMYAGKIIERGRAEDIFKNAQHPYTKALLAAVPSIDQLKENKLYSLEGNHPDMLSISDGCAFADRCEKCMKVCLRHKPPEMQISDEHFTSCWLQHEFAKGKNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q22</accession>
    <name>Q73Q22_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971236.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681808.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0622"/>
    <dbReference type="EnsemblBacteria" id="AAS11117">
        <property type="protein sequence ID" value="AAS11117"/>
        <property type="gene ID" value="TDE_0622"/>
    </dbReference>
    <dbReference type="GeneID" id="2740467"/>
    <dbReference type="KEGG" id="tde:TDE_0622"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.600"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044464_0_0_12"/>
    <dbReference type="OMA" id="RCNHASN"/>
    <dbReference type="OrthoDB" id="1398158at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="11"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="311" mass="35526" checksum="9D857580A7A03CDB" modified="2004-07-05" version="1">MEYEGRICRPPMERSSFMLPVMVGCSYNKCKFCNLFRNIKYRDLSLSEIEEELIRVKNLNGNLSKIFLGDGSAFNLETEHLLKILNLIHKYFPDCNCINMDATITGILKKTDAELETLYTQGIRTLYIGVESGLDDVLLFMNKDHTRAEAERAVSKIQKHGYSFGAHIMTGIAGKGRSIANAEATAEFLNKTKPIRVINFSMFLHKEVPLYKDIKAGKYEAASEMENLKEEKRLLELLGDEDNPIFYDGFHDYLEFRVRGTLPKDREKMLKSIQNKIESYKPLQNDYAFVNGECTPSLEKADGSGKIWKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q52</accession>
    <name>Q73Q52_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">accB</name>
        <name evidence="5" type="ordered locus">TDE_0592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971206.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681763.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0592"/>
    <dbReference type="EnsemblBacteria" id="AAS11087">
        <property type="protein sequence ID" value="AAS11087"/>
        <property type="gene ID" value="TDE_0592"/>
    </dbReference>
    <dbReference type="GeneID" id="2741555"/>
    <dbReference type="KEGG" id="tde:TDE_0592"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.572"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_3_0_12"/>
    <dbReference type="OrthoDB" id="1938042at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="4">
        <location>
            <begin position="113"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="191" mass="20046" checksum="9039366264C8A390" modified="2004-07-05" version="1">MKEDFILKVIEKFEKGDAVVLQIKQDDCELILKKEGAFPKKEAAIQSGACGGVQTAYPMPYAAIPAGFQSGLPAGIPTAPAGTTGQAAAPQAASPAAESPAQASPAASSAQNLLEVKSPIVGTFYRAPSPDSPPYVEKGSSVKKGQPLCVLEAMKMMNTLECEYDGVIEEILVSNGDLVEFDQVLFKIKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q58</accession>
    <name>Q73Q58_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971200.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669840.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0586"/>
    <dbReference type="EnsemblBacteria" id="AAS11081">
        <property type="protein sequence ID" value="AAS11081"/>
        <property type="gene ID" value="TDE_0586"/>
    </dbReference>
    <dbReference type="GeneID" id="2741022"/>
    <dbReference type="KEGG" id="tde:TDE_0586"/>
    <dbReference type="eggNOG" id="ENOG5032R4W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2246553_0_0_12"/>
    <dbReference type="OMA" id="LEWSHII"/>
    <dbReference type="OrthoDB" id="1808879at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="104" mass="11601" checksum="8C0814EE3EB52642" modified="2004-07-05" version="1">MKTILNIFSRGFIGLYAILTLIAVIAEIKGTGFKTVHLLYFVGSILLISAAVTNLPWLVYLSLVLMIPLVIFTGYVGGNLEWSHIIVRILITLLLSLLYRYSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q71</accession>
    <name>Q73Q71_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971186.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681741.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0572"/>
    <dbReference type="EnsemblBacteria" id="AAS11067">
        <property type="protein sequence ID" value="AAS11067"/>
        <property type="gene ID" value="TDE_0572"/>
    </dbReference>
    <dbReference type="GeneID" id="2741008"/>
    <dbReference type="KEGG" id="tde:TDE_0572"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.556"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_1_0_12"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="99"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="386" mass="41213" checksum="9F0FC0E2CCB3BCB8" modified="2004-07-05" version="1">MKTSNAKTKAYAFRGGSALITAAVLALVALFGMTGCPNNAGGGGSGSGNSGGGGTPAGSFEDTGDGFIKIIPTTTGIVGVDPDYTLPGTEANRKGVFRAGRKVKLSPYKLGKTEVTYELWYQVRTWAEGKGYTFANKGLEGWDGTGGGGSHPNYTNIGKPPTGNKNHPVTMVIWRDCIVWCNAYTEKTMGEGECVYRKSKTDTTVLKDATDTAACDAAYADMDKKGFRLPTEAEWEYAARWQGSDKTNAAQYGDVWLTKLNSASGAKADWNDADETKAVAWYSGNAGGTTHPVGERRANALGLHDMSGNVWEWCFDRHDNNPASNDSAYEQGGIVTDPQGAASGPYRVRRGGSWGGSAGGCTVGRREDYSPDSRYNYLGFRLAWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q90</accession>
    <name>Q73Q90_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4261 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971167.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681717.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0553"/>
    <dbReference type="EnsemblBacteria" id="AAS11048">
        <property type="protein sequence ID" value="AAS11048"/>
        <property type="gene ID" value="TDE_0553"/>
    </dbReference>
    <dbReference type="GeneID" id="2739798"/>
    <dbReference type="KEGG" id="tde:TDE_0553"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.538"/>
    <dbReference type="eggNOG" id="ENOG502Z7PZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056940_0_0_12"/>
    <dbReference type="OrthoDB" id="642722at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025357">
        <property type="entry name" value="DUF4261"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14080">
        <property type="entry name" value="DUF4261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4261" evidence="1">
        <location>
            <begin position="209"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="299" mass="34262" checksum="1B2AECEF3BA4D9A0" modified="2004-07-05" version="1">MKEKKSNGEDKILKQDMSQTADHPGMIFMVHLLMEEKCEMPEKEHIHKIMCEHLGETDCFCYDGNMAGFAPQKYSVHYEKEKLNVPPQLIIMNCSEIEKPIMDDVSATQLWNCPNGGEILETCKYQVMATDMLAAGLDYKERAEMLVNYVEALVNIYPSCKAVVFETSKKMLTREDILNCTLPKEMRFLHYAVNIRFFNIQGTNDMLVDSLGMSTLFLPDVQYHFHDLNPNDVVNHAYNVLSYIYDNDNPIEDGNTIAGLTDGNMNSDIKWKVQYENSLIQPIREVIDINTGEYASGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QC4</accession>
    <name>Q73QC4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971133.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681650.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0519"/>
    <dbReference type="EnsemblBacteria" id="AAS11014">
        <property type="protein sequence ID" value="AAS11014"/>
        <property type="gene ID" value="TDE_0519"/>
    </dbReference>
    <dbReference type="GeneID" id="2739256"/>
    <dbReference type="KEGG" id="tde:TDE_0519"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.505"/>
    <dbReference type="eggNOG" id="ENOG502ZAKW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1474554_0_0_12"/>
    <dbReference type="OrthoDB" id="1358656at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="183" mass="21573" checksum="F513E32971FA12F6" modified="2004-07-05" version="1">MKYMDWDNMHTRLEALYILDNALTDPSEDDLRLVRKKKLDSNLKYVIDNGAGDSLSVIFTETVVLVKGFAHENSLNQFAADEWNQSIIDKMYEGLDEKLINLFSVDERAETTFFIWYDGAVHQNQTDEHDGDYWLLGYAFDKYERFREFVTEYYSMKFDDNLLRKLYTDSVLSYFELSELIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QG7</accession>
    <name>Q73QG7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cobW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971090.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672626.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0476"/>
    <dbReference type="EnsemblBacteria" id="AAS10971">
        <property type="protein sequence ID" value="AAS10971"/>
        <property type="gene ID" value="TDE_0476"/>
    </dbReference>
    <dbReference type="GeneID" id="2740523"/>
    <dbReference type="KEGG" id="tde:TDE_0476"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.461"/>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1193419_0_0_12"/>
    <dbReference type="OMA" id="DMCPDHF"/>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004392">
        <property type="entry name" value="Hyd_mat_HypB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30134">
        <property type="entry name" value="PTHR30134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="2">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="238" mass="25804" checksum="FD88908F46597B5D" modified="2004-07-05" version="1">MNLIIFSGPPSSGKTSVILKTIDALKKQNIKTGAVKFDCLYTDDDLLYQKAGVPVQKGISGSLCPDHFFVSNIEEAVQWGIKEGLDLLVSESAGLCNRCSPYIKNILGICVIDNLSGINTPKKIGPLLKSADIVVITKGDIVSQAEREVFAARVNAVNPRAVIMHVNGLTGQGAFELSTLLTDKAEDISTVQGMELRFPMPAALCSYCLGETRIGENFQMGNIRKMKIAEEQGRKNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QH3</accession>
    <name>Q73QH3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">ftsH</name>
        <name evidence="9" type="ordered locus">TDE_0470</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971084.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666001.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0470"/>
    <dbReference type="EnsemblBacteria" id="AAS10965">
        <property type="protein sequence ID" value="AAS10965"/>
        <property type="gene ID" value="TDE_0470"/>
    </dbReference>
    <dbReference type="GeneID" id="2739224"/>
    <dbReference type="KEGG" id="tde:TDE_0470"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.455"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_12"/>
    <dbReference type="OMA" id="YDKQGGG"/>
    <dbReference type="OrthoDB" id="190468at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="8">
        <location>
            <begin position="237"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="245"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="658" mass="73332" checksum="269F38D6AC52B0B9" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QN7</accession>
    <name>Q73QN7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA-ATPase_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971020.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681436.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0406"/>
    <dbReference type="EnsemblBacteria" id="AAS10901">
        <property type="protein sequence ID" value="AAS10901"/>
        <property type="gene ID" value="TDE_0406"/>
    </dbReference>
    <dbReference type="GeneID" id="2740152"/>
    <dbReference type="KEGG" id="tde:TDE_0406"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.393"/>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021114_0_1_12"/>
    <dbReference type="OMA" id="DWIEYPV"/>
    <dbReference type="OrthoDB" id="191489at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018631">
        <property type="entry name" value="AAA-ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012547">
        <property type="entry name" value="PDDEXK_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09820">
        <property type="entry name" value="AAA-ATPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08011">
        <property type="entry name" value="PDDEXK_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA-ATPase_like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="539" mass="62520" checksum="5B6ECAD92B1A4E4E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QP1</accession>
    <name>Q73QP1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971016.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0402"/>
    <dbReference type="EnsemblBacteria" id="AAS10897">
        <property type="protein sequence ID" value="AAS10897"/>
        <property type="gene ID" value="TDE_0402"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0402"/>
    <dbReference type="HOGENOM" id="CLU_3376597_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="34" mass="3383" checksum="2B87BD050388961E" modified="2004-07-05" version="1">MAARGKGMGLKGKGKTTALNGGLSLPLIVLTKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QT2</accession>
    <name>Q73QT2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sodium/glutamate symporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the sodium-dependent transport of glutamate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970975.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956723.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0361"/>
    <dbReference type="EnsemblBacteria" id="AAS10856">
        <property type="protein sequence ID" value="AAS10856"/>
        <property type="gene ID" value="TDE_0361"/>
    </dbReference>
    <dbReference type="GeneID" id="2741081"/>
    <dbReference type="KEGG" id="tde:TDE_0361"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.351"/>
    <dbReference type="eggNOG" id="COG0786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040907_0_0_12"/>
    <dbReference type="OMA" id="PTAMVNM"/>
    <dbReference type="OrthoDB" id="1284248at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015501">
        <property type="term" value="F:glutamate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015813">
        <property type="term" value="P:L-glutamate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02062">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004445">
        <property type="entry name" value="GltS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36178">
        <property type="entry name" value="PTHR36178"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03616">
        <property type="entry name" value="Glt_symporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0915">Sodium</keyword>
    <keyword evidence="1" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="1" id="KW-0769">Symport</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="457" mass="49748" checksum="167744889C6663C2" modified="2004-07-05" version="1">MVIHMNMYQSLGFAIAWLLVGRFIKAKFEFFQKYCIPAPIVGGFLFALISLALHVTRVLDFEFDTTLQTYWMVMFFTSVGYNAGFSILRDGGKKVFVFLAVAIVFAILQNVVAQGAARLINFSPMLAVMLGSTSFTGGFGTAASFAPIVDPENTLGALSLAVAVPTFGSLISSILGGPVGNRLIKKYGLQPSNADESVRIDESGNIIKTKKVVKKVEAVHPSFIKRLFFNPTKGREEGQEVVTVQEEVIHEASAKGEVDNSTTSSEKHLSSEKLLMSFMLLVLASGFGLFVTNHLNSLSPKFKFPIYIGAMICAAIIRNIADTSKKFKVNMDEIDALGNISLNMFLALALVSLKLWQLVSLAIPLMIILSAQIVLLYLYTRFVTFKVMGGDYDAAVITAGHIGFGFAATPNAMANMGSICEKYGYSKIAFFVVPIVGSLFIDFFNIMIIGITIGLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QT9</accession>
    <name>Q73QT9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">General stress protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-10" db="PDB data bank">
            <title>Crystal structure of the general stress protein 14 (TDE0354) in complex with FMN from Treponema denticola, Northeast Structural Genomics Consortium Target TdR58.</title>
            <authorList>
                <person name="Forouhar F."/>
                <person name="Lew S."/>
                <person name="Seetharaman J."/>
                <person name="Janjua H."/>
                <person name="Sahdev S."/>
                <person name="Xiao R."/>
                <person name="Ciccosanti C."/>
                <person name="Foote E.L."/>
                <person name="Belote R.L."/>
                <person name="Nair R."/>
                <person name="Everett J.K."/>
                <person name="Acton T.B."/>
                <person name="Rost B."/>
                <person name="Montelione G.T."/>
                <person name="Tong L."/>
                <person name="Hunt J.F."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH FMN</scope>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970968.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681338.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="PDB" id="3F2V">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A=1-184"/>
    </dbReference>
    <dbReference type="PDBsum" id="3F2V"/>
    <dbReference type="SMR" id="Q73QT9"/>
    <dbReference type="STRING" id="243275.TDE_0354"/>
    <dbReference type="DNASU" id="2740161"/>
    <dbReference type="EnsemblBacteria" id="AAS10849">
        <property type="protein sequence ID" value="AAS10849"/>
        <property type="gene ID" value="TDE_0354"/>
    </dbReference>
    <dbReference type="GeneID" id="2740161"/>
    <dbReference type="KEGG" id="tde:TDE_0354"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.343"/>
    <dbReference type="eggNOG" id="COG2249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058643_0_2_12"/>
    <dbReference type="OMA" id="QHRSEVN"/>
    <dbReference type="OrthoDB" id="1143659at2"/>
    <dbReference type="EvolutionaryTrace" id="Q73QT9"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003680">
        <property type="entry name" value="Flavodoxin_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02525">
        <property type="entry name" value="Flavodoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3F2V"/>
        </source>
    </evidence>
    <sequence length="184" mass="20796" checksum="8C868AC89266CC01" modified="2004-07-05" version="1">MPKTLIILAHPNISQSTVHKHWSDAVRQHTDRFTVHELYAVYPQGKIDVAAEQKLIETHDSLVWQFPIYWFNCPPLLKQWLDEVLTYGWAYGSKGKALKGRKIALAVSLGAPAADYRADGAVGCSVAEVLRPFELTAKYCNADYRPPFTFHTIDSNAGYSEAARQEVERSARDYLAWLDALQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QV0</accession>
    <name>Q73QV0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970957.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0343"/>
    <dbReference type="ESTHER" id="trede-q73qv0">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10838">
        <property type="protein sequence ID" value="AAS10838"/>
        <property type="gene ID" value="TDE_0343"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0343"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.332"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067813_0_0_12"/>
    <dbReference type="OMA" id="ARITSGH"/>
    <dbReference type="OrthoDB" id="1498437at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="68"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="372" mass="42719" checksum="41758EE3A953A8D0" modified="2004-07-05" version="1">MLKFIAILFCVLIVLAVFYVLRNLNYDYSGEKFVKNRSLSLGLEEKQFYLKDGSVINYAEGPDNGPDMVLLHGQMVDWKDYRTVLPELVKKFHVFALDYYGHGKSSKNPDLYNIERIGSDIALFIQEKVGSKAIISGHSSGALIVAYIAATYPENVKAIVLEDGPFFATEKGRAENTFSYKTFQNIHNYLTEKPNITYFEHYLKNDPMRTLFNMDGKDNWTKIVAEPAMKRFRKDLTKIPIIWYYPPELGVNTLLQLTANLQDGTGDYDLRFADAFYDFSFFNGIKQEDMLKQISVPTCILHVNPPKNTTPSYYTEEGMLISAMDEKDAKHVKELIRGSILVEGFDSMHNIHEDKPKEFLKKVAEFLDKIEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-29" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R08</accession>
    <name>EFG1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor G 1</fullName>
            <shortName evidence="1">EF-G 1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fusA1</name>
        <name type="synonym">fusA-1</name>
        <name type="ordered locus">TDE_0285</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970899.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681223.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73R08"/>
    <dbReference type="SMR" id="Q73R08"/>
    <dbReference type="STRING" id="243275.TDE_0285"/>
    <dbReference type="EnsemblBacteria" id="AAS10780">
        <property type="protein sequence ID" value="AAS10780"/>
        <property type="gene ID" value="TDE_0285"/>
    </dbReference>
    <dbReference type="GeneID" id="2741602"/>
    <dbReference type="KEGG" id="tde:TDE_0285"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.275"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_12"/>
    <dbReference type="OMA" id="AVCQIPW"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091252" description="Elongation factor G 1">
        <location>
            <begin position="1"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="3"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="76"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <sequence length="683" mass="75414" checksum="92127C69B9AD178C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R12</accession>
    <name>Q73R12_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970895.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676626.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0281"/>
    <dbReference type="EnsemblBacteria" id="AAS10776">
        <property type="protein sequence ID" value="AAS10776"/>
        <property type="gene ID" value="TDE_0281"/>
    </dbReference>
    <dbReference type="GeneID" id="2741598"/>
    <dbReference type="KEGG" id="tde:TDE_0281"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.271"/>
    <dbReference type="eggNOG" id="ENOG5031CT5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2866531_0_0_12"/>
    <dbReference type="OMA" id="YMETIEF"/>
    <dbReference type="OrthoDB" id="2056600at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="65" mass="7571" checksum="D5896F349EDD9E2E" modified="2004-07-05" version="1">MVETALKKKAMDYFAMLDNEQARMVISYMETIEFPAEKRQHSIADLKGKIQFADGYDYKAMRSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R76</accession>
    <name>Q73R76_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970831.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0215"/>
    <dbReference type="EnsemblBacteria" id="AAS10712">
        <property type="protein sequence ID" value="AAS10712"/>
        <property type="gene ID" value="TDE_0215"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0215"/>
    <dbReference type="HOGENOM" id="CLU_3367946_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="35" mass="4184" checksum="3D615BBA6298B153" modified="2004-07-05" version="1">MILYSYNAPVISYHKTLCDTRMQNVSRETFYVLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R79</accession>
    <name>Q73R79_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NMT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970828.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681111.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0212"/>
    <dbReference type="EnsemblBacteria" id="AAS10709">
        <property type="protein sequence ID" value="AAS10709"/>
        <property type="gene ID" value="TDE_0212"/>
    </dbReference>
    <dbReference type="GeneID" id="2739369"/>
    <dbReference type="KEGG" id="tde:TDE_0212"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.206"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062584_0_0_12"/>
    <dbReference type="OMA" id="VGVHEWK"/>
    <dbReference type="OrthoDB" id="785019at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027024">
        <property type="entry name" value="UCP027386_ABC_sbc_TM0202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027386">
        <property type="entry name" value="UCP027386_ABC_sbc_TM0202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMT1" evidence="1">
        <location>
            <begin position="98"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="325" mass="35390" checksum="E6C7D5044EFEC8D4" modified="2004-07-05" version="1">MKKIYSSFFFLFVGLSLLFAGGTKEKSVNDSFKAKVVLPAGAPAAALSKLVYEKTQFDNSETEYEVVSGPELLQARVLSGEADIIAVPTNLASVLYSKQKNIKLLAPIVWGNLYFISSEPVSSIADLKGKTIYSFGRNNTPDLTAREVLKKNGIDPDKDVSFEYLSAVGDIPSAFISGKAKYALAAEPSLSMIMTKKPNTKIVVDIQEEWKKAFSGASYPQASLIVNAEFLQKHPEYVSAFLDKAKESSEWVKENPQKAAEYASKIAALPPPPILSKAIPKLNIVFVEAGKARPAVEAYLKVLAEADPKFIGGSLPDDAFYYKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RC4</accession>
    <name>Q73RC4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970782.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681048.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0166"/>
    <dbReference type="EnsemblBacteria" id="AAS10663">
        <property type="protein sequence ID" value="AAS10663"/>
        <property type="gene ID" value="TDE_0166"/>
    </dbReference>
    <dbReference type="GeneID" id="2739599"/>
    <dbReference type="KEGG" id="tde:TDE_0166"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.163"/>
    <dbReference type="eggNOG" id="ENOG5030U9I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1011720_0_0_12"/>
    <dbReference type="OMA" id="IACYIMI"/>
    <dbReference type="OrthoDB" id="1732013at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="273" mass="30872" checksum="CD2B93F9E5C58CC7" modified="2004-07-05" version="1">MGRIFKYEIRRRLNTILILSGTMIVLSIGSMVLLGIFKTPFSSMGTTGNLWLGLTFFALAFIPLVMFFTCSNGHIDELLYKDTNYLMLTIPIRSEAILGGRILAGFVEYLIYALIACIFFIIIGAQQAVFYGQSGQTLISVLGDVFYQIFIQNFLPFLYGVLLLVSSFLLVGTAFMFVKALTRSFIRKKMAAQIIAVILFILIFERIIALGTYLSTRWDLVQYIDLRLMSSQYYSLVNIQPLPVHLVTIIMTMIISAGFFAATSWLFDKKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RD4</accession>
    <name>Q73RD4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylate/guanylate cyclase catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970772.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681033.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0155"/>
    <dbReference type="EnsemblBacteria" id="AAS10653">
        <property type="protein sequence ID" value="AAS10653"/>
        <property type="gene ID" value="TDE_0155"/>
    </dbReference>
    <dbReference type="GeneID" id="2741743"/>
    <dbReference type="KEGG" id="tde:TDE_0155"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.153"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_105_5_12"/>
    <dbReference type="OMA" id="HKTIANW"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011623">
        <property type="entry name" value="7TMR_DISM_rcpt_extracell_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07695">
        <property type="entry name" value="7TMR-DISM_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004286060" evidence="2">
        <location>
            <begin position="22"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="444"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="623" mass="70383" checksum="DD56697E77096C67" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RE2</accession>
    <name>Q73RE2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS10645.1"/>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS10645">
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        <property type="gene ID" value="TDE_0147"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2866490_0_0_12"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="64" mass="7305" checksum="43F640F55288FA43" modified="2004-07-05" version="1">MNAAVNMTKTIKIKGFILLCIIPLHSPIEKNIIKQGITINDPVLENTKREEKRTIKKFSKNKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RK7</accession>
    <name>Q73RK7_TREDE</name>
    <protein>
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            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS10579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS10579">
        <property type="protein sequence ID" value="AAS10579"/>
        <property type="gene ID" value="TDE_0081"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.82"/>
    <dbReference type="eggNOG" id="COG5459">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="44"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="462" mass="53030" checksum="29A0301C01878639" modified="2004-07-05" version="1">MTEQNKPFYEKFVKKNETKIHHQKKKEIDEPLTKEKRSEKKNNREEFPVKIVKTKNTGKNIFKENDADTKALLNSFDLIIKDALKLSSKQTASVPKDIRILFHELTNERGSRKVNYLNNPVKLTAYIYHYMWWNLVRISKLIGNLDFDLKDGDIIADFGCGPMTLMCAFWIAKPELRSKKLHWYCADISGKALAAGEALFNSLFAFTNQNAGIKQASNWKLTKLNGSFGLPLKEKVNLFVSANMFNEIFWDSSIKIEGEAERAARTIRHYLQKDGAALIIEPGIPLAGEFVSTLRKNFIEKKYKIISPCPHAEICPIPGKKTAEQKNIKYPIASDKWCHFSFYADDAPPKLFELSEAARLEKTRASLSFIYCRGEEKKEKPVESKKEKKDFLARISSEIIKLDDGKIGRYACSEKGFLLLTEKKGPRSKLKEYVDGSLIKIEDEKINRFFHDRKTGALIIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RL6</accession>
    <name>Q73RL6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0072</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
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        <property type="protein sequence ID" value="AAS10570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680924.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0072"/>
    <dbReference type="EnsemblBacteria" id="AAS10570">
        <property type="protein sequence ID" value="AAS10570"/>
        <property type="gene ID" value="TDE_0072"/>
    </dbReference>
    <dbReference type="GeneID" id="2741687"/>
    <dbReference type="KEGG" id="tde:TDE_0072"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.73"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="dCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
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        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14827">
        <property type="entry name" value="dCache_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="327"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="426"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="712" mass="79044" checksum="BAB58E96C0CCDCC7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RN6</accession>
    <name>Q73RN6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0049</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970666.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676321.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0049"/>
    <dbReference type="EnsemblBacteria" id="AAS10547">
        <property type="protein sequence ID" value="AAS10547"/>
        <property type="gene ID" value="TDE_0049"/>
    </dbReference>
    <dbReference type="GeneID" id="2741664"/>
    <dbReference type="KEGG" id="tde:TDE_0049"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.51"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057504_0_2_12"/>
    <dbReference type="OMA" id="SEHPAFH"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="296" mass="34785" checksum="58A2020A40F5C5AF" modified="2004-07-05" version="1">MKRLFKVTLRNDYAFKRVFGVEENKDVLQDLLECILDIPSEDIADLELLDKELHKDLISDKTGVLDVKLRLKNNTIIDIEIQNRWNSEFVQRTIFYWAKMYTENLKTGEVYTKLPRCITINIVGEGFDLNNLIHSEYNVVEKHINDRLSDELEIHFLNLAKIKEQQENIEQDEKKKKLYSWLKFIETDDGEVRNMLAENSEMMAKANTTINIMEMSPKEKWLYENRMKYEHDKASWKHMGYQEGILQGEINGRKEGIKQGAYQTKLETARNLFRLGLSIENIAEVTGLSKEEVQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RQ0</accession>
    <name>Q73RQ0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970652.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673332.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0035"/>
    <dbReference type="EnsemblBacteria" id="AAS10533">
        <property type="protein sequence ID" value="AAS10533"/>
        <property type="gene ID" value="TDE_0035"/>
    </dbReference>
    <dbReference type="GeneID" id="2741650"/>
    <dbReference type="KEGG" id="tde:TDE_0035"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.37"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_34_1_12"/>
    <dbReference type="OMA" id="IAGFDGW"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017255">
        <property type="entry name" value="AcTrfase_GNAT_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037663">
        <property type="entry name" value="Acetyltransf_GNAT_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="146" mass="16197" checksum="D3987406A20F79A1" modified="2004-07-05" version="1">MNIRIMTANDYDAVYALWMSCIGMGLNTIDDSKEGITKFLIRNPETCFVAESGEKIIGVILTGNDGRRGYIYHLAVIPECRKQGIGAQLLSAALKALKKIGIVKVALVVFGKNKSGNDFWEKMGFTSRDDLVYRNKALTDICRIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RQ1</accession>
    <name>Q73RQ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970651.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680892.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0034"/>
    <dbReference type="EnsemblBacteria" id="AAS10532">
        <property type="protein sequence ID" value="AAS10532"/>
        <property type="gene ID" value="TDE_0034"/>
    </dbReference>
    <dbReference type="GeneID" id="2741649"/>
    <dbReference type="KEGG" id="tde:TDE_0034"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.36"/>
    <dbReference type="eggNOG" id="ENOG502ZDQY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1137606_0_0_12"/>
    <dbReference type="OrthoDB" id="1865993at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="245" mass="28371" checksum="E5B4A04B97B21606" modified="2004-07-05" version="1">MKKISFELIKKIDFVLIFIFLILGIITWAIVMINIFNPFSGSHTVSNAVTIVEDDTKEEIREYIEFNKKLKDVFVFNLKSSKIKADGLYDDISASSIKSSLSFSGKTHNEGITNFIFIKDISYEESKLFDSNIFIYKYKFAEEKTGKDIYCDKNIYAVVNEDTNNDKTLNSEDNIALYISDYDGKNLIKISNSVYKVRITDNNQLLFTEYDGSLLTFFLYDINLNKKTKLKSAEQEVPEKYISFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RR9</accession>
    <name>Q73RR9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970633.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680871.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0016"/>
    <dbReference type="EnsemblBacteria" id="AAS10514">
        <property type="protein sequence ID" value="AAS10514"/>
        <property type="gene ID" value="TDE_0016"/>
    </dbReference>
    <dbReference type="GeneID" id="2741631"/>
    <dbReference type="KEGG" id="tde:TDE_0016"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.18"/>
    <dbReference type="eggNOG" id="COG2256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_0_3_12"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="OrthoDB" id="977094at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="52"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="441" mass="49071" checksum="FA6901DF40ECC130" modified="2004-07-05" version="1">MSKDLFEAAASSSKQNEPLASRMRPISLDEYIGQEHIIGKGCLLRRAIQADRLSSLIFFGPPGTGKTTLARVIANTTKSNFLSLNAVLAGVQQIREAVTNAEENKKLYNRKTILFVDEVHRWNKSQQDALLPWVENGTIILIGATTENPYFEVNKALVSRSRVFELKPLTDNDLKKVAQFALTNKERGYGNWKIEFEAGALEHLIDTASGDARSLLNALELAVETSAEHWPPEENFKITISLKAAEESIQKKVVLYDRDGDYHYDVISAFIKSIRGSDPDAAVYWLARMIAAGEDPRFIFRRMLISACEDIGLASPGAVSVVAGAAEAFDRVGMPEGRYHLAHAALYLATCPKSNSAEAFFKALDCVQKENKEVPNHLKDSNRDGEALGHGEGYLYPHAFEGHWVKQQYLPDGLEGTHFYEPSNQGYEGKIKPEILKKRQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>P61038</accession>
    <name>LNT2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apolipoprotein N-acyltransferase 2</fullName>
            <shortName evidence="1">ALP N-acyltransferase 2</shortName>
            <ecNumber evidence="1">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lnt2</name>
        <name type="ordered locus">TDE_2299</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972899.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680216.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61038"/>
    <dbReference type="SMR" id="P61038"/>
    <dbReference type="STRING" id="243275.TDE_2299"/>
    <dbReference type="EnsemblBacteria" id="AAS12818">
        <property type="protein sequence ID" value="AAS12818"/>
        <property type="gene ID" value="TDE_2299"/>
    </dbReference>
    <dbReference type="GeneID" id="2740264"/>
    <dbReference type="KEGG" id="tde:TDE_2299"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2169"/>
    <dbReference type="eggNOG" id="COG0815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019563_1_1_12"/>
    <dbReference type="OMA" id="YVALVPW"/>
    <dbReference type="OrthoDB" id="1291198at2"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000178104" description="Apolipoprotein N-acyltransferase 2">
        <location>
            <begin position="1"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="228"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <sequence length="525" mass="59649" checksum="5404D4F067AC62C8" modified="2004-04-26" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-10" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>P61188</accession>
    <name>HTPG_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein HtpG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein HtpG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">High temperature protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">htpG</name>
        <name type="ordered locus">TDE_2480</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone. Has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973078.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957241.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61188"/>
    <dbReference type="SMR" id="P61188"/>
    <dbReference type="STRING" id="243275.TDE_2480"/>
    <dbReference type="EnsemblBacteria" id="AAS12997">
        <property type="protein sequence ID" value="AAS12997"/>
        <property type="gene ID" value="TDE_2480"/>
    </dbReference>
    <dbReference type="GeneID" id="2741453"/>
    <dbReference type="KEGG" id="tde:TDE_2480"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2346"/>
    <dbReference type="eggNOG" id="COG0326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_3_0_12"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="246194at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000063017" description="Chaperone protein HtpG">
        <location>
            <begin position="1"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="A; substrate-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="B" evidence="1">
        <location>
            <begin position="349"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="C" evidence="1">
        <location>
            <begin position="566"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00505"/>
        </source>
    </evidence>
    <sequence length="640" mass="73496" checksum="98DB8F6CFEDC17BD" modified="2004-05-10" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-10" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>P61199</accession>
    <name>LIPA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoyl synthase</fullName>
            <ecNumber evidence="1">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lip-syn</fullName>
            <shortName evidence="1">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lipA</name>
        <name type="ordered locus">TDE_1575</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972181.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61199"/>
    <dbReference type="SMR" id="P61199"/>
    <dbReference type="STRING" id="243275.TDE_1575"/>
    <dbReference type="EnsemblBacteria" id="AAS12092">
        <property type="protein sequence ID" value="AAS12092"/>
        <property type="gene ID" value="TDE_1575"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1575"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1504"/>
    <dbReference type="eggNOG" id="COG0320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033144_2_1_12"/>
    <dbReference type="OMA" id="PYCDIDF"/>
    <dbReference type="OrthoDB" id="1184806at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000102374" description="Lipoyl synthase">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="56"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="290" mass="32592" checksum="5FF6BFA727192040" modified="2004-05-10" version="1">MNFKAGFMTCNQRKPDWLKIKLPTGELSQEVSNTIKIHKLNTICTSGKCPNQGECWRCGTATFMICGNICTRACKFCNVPTGCPLPLNPNEPMEIAQSVEALKLKHVVLTSVDRDDIKDFGASHWVKVIRAVKQKTPNVTMEVLIPDFQGHEDLVSMIIEAKPEVISHNLETVRRLSPHVRSRATYDTSLKVLKQIADSGLVCKSGIMLGLGETRAEILETMDDLRKINCKVMTIGQYLRPSIKNIEVKEYVRPEVFEEYKQIGLEKGFSFVESGPLVRSSYHAEKHVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J24</accession>
    <name>Q73J24_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973350.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667009.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2752"/>
    <dbReference type="EnsemblBacteria" id="AAS13269">
        <property type="protein sequence ID" value="AAS13269"/>
        <property type="gene ID" value="TDE_2752"/>
    </dbReference>
    <dbReference type="GeneID" id="2740719"/>
    <dbReference type="KEGG" id="tde:TDE_2752"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2598"/>
    <dbReference type="eggNOG" id="COG4545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159829_0_1_12"/>
    <dbReference type="OMA" id="CPDTEPF"/>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017167">
        <property type="entry name" value="UCP037291_glutaredoxin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037291">
        <property type="entry name" value="UCP037291_gluthr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="90" mass="10555" checksum="5FB1048B992D736E" modified="2004-07-05" version="1">MKKQLFLFGSKLCPDCGPAKEYLERKGVKFRYFDITEDLGYLKFLLKYRDERAEFDQLKKEGKIGIPCLMVGDGEEFVFDIEEADLSKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J60</accession>
    <name>Q73J60_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973314.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680765.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2716"/>
    <dbReference type="EnsemblBacteria" id="AAS13233">
        <property type="protein sequence ID" value="AAS13233"/>
        <property type="gene ID" value="TDE_2716"/>
    </dbReference>
    <dbReference type="GeneID" id="2740935"/>
    <dbReference type="KEGG" id="tde:TDE_2716"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2565"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_1_12"/>
    <dbReference type="OMA" id="YLCGKFG"/>
    <dbReference type="OrthoDB" id="1562270at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="218" mass="23880" checksum="6FBB34D63D16F02D" modified="2004-07-05" version="1">MKKACIFDLDGTLTNSLYSIAHFLNAETAKYGIPPVDAEEFKILTGNGARKLVQRVLERAGKNDKDLEEKILTEYNAAYDADPVYLCEAYPGIKKLLADLIKNGISVNVLSNKPHPTTEKVVKTIFGENTFSCILGARDSVALKPDPAGVYEILKMLKLEKKDFLYIGDTATDVQTGKNAGLFTIGVLWGFRKRPELEQAGADAIISSPEEILKIALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JA5</accession>
    <name>Q73JA5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl transferase, group 4 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973268.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680715.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2670"/>
    <dbReference type="EnsemblBacteria" id="AAS13187">
        <property type="protein sequence ID" value="AAS13187"/>
        <property type="gene ID" value="TDE_2670"/>
    </dbReference>
    <dbReference type="GeneID" id="2741115"/>
    <dbReference type="KEGG" id="tde:TDE_2670"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2522"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_2_4_12"/>
    <dbReference type="OMA" id="WRLLGHF"/>
    <dbReference type="OrthoDB" id="728505at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS13187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="355" mass="39569" checksum="78A15CFA579FB7F8" modified="2004-07-05" version="1">MTAIQFILYIIAIPCALSAFFVYLAILFSKKHNLYDKTGGRKIHSGNIPRIGGVGFGFAYIISSLILHFRFPEFRLLHSNFFYIALGGLLIFIMGLWDDIKNWRAIFKLLVQSCAAIIVLYGGYTFKKISFGPIGFFWYMGPETYVITFLWIIGITNAINLVDGIDGQAGCLGVSVLLTYAAIYYSIGISSIIIFRVLILAFSVVGFLFFNLSRPSAKIFMGDCGSQILGFVLAILPLIPSPEGYEAAGIQFASVILMLPIFDTVAAIWRRVREKRPIGEGDKFHLHHKLMLIGFSPRGALSVFMILQLIINLFAGMAIILQGVRALVVLIGLILVGLLFFTLIHYEKEKIINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JB8</accession>
    <name>Q73JB8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Precorrin-2 C20-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973255.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680705.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2657"/>
    <dbReference type="EnsemblBacteria" id="AAS13174">
        <property type="protein sequence ID" value="AAS13174"/>
        <property type="gene ID" value="TDE_2657"/>
    </dbReference>
    <dbReference type="GeneID" id="2741102"/>
    <dbReference type="KEGG" id="tde:TDE_2657"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2511"/>
    <dbReference type="eggNOG" id="COG2243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076014_2_1_12"/>
    <dbReference type="OMA" id="MEYPVTT"/>
    <dbReference type="OrthoDB" id="1209876at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS13174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="222" mass="25034" checksum="7943B852C007BAD6" modified="2004-07-05" version="1">MKNIFAVGTGPGSPEYLTLQAVKTLENADLIFAPNNKGKNMALDTVKDFIKNKEVLFLDFPMGFVSEEDYKIQAEKILKKTKENSNTVILTIGDPMIYSTFIYMMPYFKIPEINLQIISGIPSAVAAAGRAQIPLAEKAEVLTITDHLNEEILNSSSSIALLKTSKQKKFILKEFEKNGFDYVYIKRATMEHESILSKDKKEKILEDEDYISLIIARKQKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JD2</accession>
    <name>Q73JD2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, FAD-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973241.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957284.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2643"/>
    <dbReference type="EnsemblBacteria" id="AAS13160">
        <property type="protein sequence ID" value="AAS13160"/>
        <property type="gene ID" value="TDE_2643"/>
    </dbReference>
    <dbReference type="GeneID" id="2741088"/>
    <dbReference type="KEGG" id="tde:TDE_2643"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2498"/>
    <dbReference type="eggNOG" id="COG0579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_3_1_12"/>
    <dbReference type="OMA" id="GVHFTRM"/>
    <dbReference type="OrthoDB" id="1371190at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="3"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="407"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="489" mass="53828" checksum="3BABC7CFB7D39820" modified="2004-07-05" version="1">MYDIIIIGAGVVGACIARELSKYELKIAVLEKELEFGCGTSKANSGIIHGGYDAKEGSLKAKLNVRGNFLVRSLKEKLDLRFKQLGSLVIAFNEEEKQELSTLYERGLKNGVEGLEIWDRERLLKEEPNLSKEAVGALYCGTAGVICPFDMTAAFMENAVINGIDFLPENEVIAIEKENEAYTIKTKSSKTEQRVFKTKLVINAAGLYSDKIAKMAGDEDFKILPRRGEYRLFDKSYTNLVNHICFQAPSKMGKGILVLPSYHGNFLAGPSAENIDDAEDTSVSDQGLAQVEEKALKTVPSLNFKNTIRIFAGVRARPDTGDFMIYASKNSKGIIHAGGIESPGLSSAPAIGEYVAELVKKEADDLKIPFNKKKNFNENRRAIGHFAGLSAEEQDSLIKENPLYGHVICRCETVTEAEIVEAIHRPAGARTVDGIKRRVRPGSGRCQGGFCEPHVLQILSRELKIPIEKIQKDRRNSPIVYGKLKGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JK1</accession>
    <name>Q73JK1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nitroimidazole resistance protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973016.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674090.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2417"/>
    <dbReference type="EnsemblBacteria" id="AAS12935">
        <property type="protein sequence ID" value="AAS12935"/>
        <property type="gene ID" value="TDE_2417"/>
    </dbReference>
    <dbReference type="GeneID" id="2739842"/>
    <dbReference type="KEGG" id="tde:TDE_2417"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2283"/>
    <dbReference type="eggNOG" id="COG3467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067890_1_0_12"/>
    <dbReference type="OMA" id="FEFTEKM"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="158" mass="17821" checksum="1CCEFFC69F310C6E" modified="2004-07-05" version="1">MRRVDRAVTDNRQIQSIIEKAKVVHIGMIDNDRPYVVPMQYGFIFNEGKLTLYVHCAKKGRKLDIINKNSHVFIELETEAVIISGGEIPCEYGSEYASVMGDGTAVFVEDVKEKILGLQLLMKTQTGRDFEITEQMTKQVTVLRIDVPCVTAKSRAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JM3</accession>
    <name>Q73JM3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972993.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12912">
        <property type="protein sequence ID" value="AAS12912"/>
        <property type="gene ID" value="TDE_2394"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2394"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2261"/>
    <dbReference type="HOGENOM" id="CLU_3399009_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="31" mass="3838" checksum="D7ED4AA190AA5ADE" modified="2004-07-05" version="1">MQFVNKLREKTFFANCYLLQKVFMGVFYEKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JM9</accession>
    <name>CLPP2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease proteolytic subunit 2</fullName>
            <ecNumber evidence="1">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endopeptidase Clp 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpP2</name>
        <name type="ordered locus">TDE_2388</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972987.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667667.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JM9"/>
    <dbReference type="SMR" id="Q73JM9"/>
    <dbReference type="STRING" id="243275.TDE_2388"/>
    <dbReference type="EnsemblBacteria" id="AAS12906">
        <property type="protein sequence ID" value="AAS12906"/>
        <property type="gene ID" value="TDE_2388"/>
    </dbReference>
    <dbReference type="GeneID" id="2740690"/>
    <dbReference type="KEGG" id="tde:TDE_2388"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2256"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_4_0_12"/>
    <dbReference type="OMA" id="RFIQPHA"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <feature type="chain" id="PRO_0000179703" description="ATP-dependent Clp protease proteolytic subunit 2">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <sequence length="200" mass="22456" checksum="063D13364B91145B" modified="2004-07-05" version="1">MNFINETNEEKKNKTNDDDALMQKFLNTRQIILAGEINKELSEKIVRQLLLMESLSATKPIYIYIDSPGGDADAGFAIFDMIRFIKAPVYTIGMGLVASAASIILLAASKERRFGMPNSHYLIHQPLSGIKGVATEIEIHAKELEKMRVKINKLIAEETGTDEKKVAKDTDRDCWLNAKESVEYGLISKIAKNRKDIPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JP0</accession>
    <name>Q73JP0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Surface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973041.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680383.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2442"/>
    <dbReference type="EnsemblBacteria" id="AAS12960">
        <property type="protein sequence ID" value="AAS12960"/>
        <property type="gene ID" value="TDE_2442"/>
    </dbReference>
    <dbReference type="GeneID" id="2739867"/>
    <dbReference type="KEGG" id="tde:TDE_2442"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2310"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1199365_0_0_12"/>
    <dbReference type="OrthoDB" id="956253at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="231" mass="26495" checksum="8C6A5C13FB12806F" modified="2004-07-05" version="1">MYKINFLVIFLYIFMFVMKLYPNNTDTNIDSFEYVFNVQKNYIVISRYIGKEMKVTIPEKIDGCPVGEIGEYCFFGNSYIKSVILPDSIVIINNNAFRNSSLTKIVLSNSLRYIGDSVFCDTPLKSIILPDGLEYIGEYAFYNTAITRLIIPDSVKKIDWWAFGNCEKLEYIKLSKSLDQIPSRFCENCINLKDIENIGFCPVQSTAFVGCRKLPITVRKKLIDAGYGNNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JQ2</accession>
    <name>Q73JQ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973055.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680413.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2457"/>
    <dbReference type="EnsemblBacteria" id="AAS12974">
        <property type="protein sequence ID" value="AAS12974"/>
        <property type="gene ID" value="TDE_2457"/>
    </dbReference>
    <dbReference type="GeneID" id="2739642"/>
    <dbReference type="KEGG" id="tde:TDE_2457"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2325"/>
    <dbReference type="HOGENOM" id="CLU_959571_0_0_12"/>
    <dbReference type="OrthoDB" id="177634at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285915" evidence="2">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="290" mass="33079" checksum="58CCE106881AFD97" modified="2004-07-05" version="1">MYKKPIEIFMMLFGMLVVLASCNEDGNTNTSKQVKNAKPWPSDYFQYELTGDGTGVVITGFRQEAYEKKANSQDKMFYMPKSNVLYFPAEIENLPVKGICFTQERMSRLANENGDGDEIPWDLVIIPDTVEFVTSTYNVNKVKICAKKIVPGKKAVYGYGNEKGLSSKKPYPNNPDYEFFFLEEFIVPDTVKQKLGAYYAFNGTTVIIPDRIEELKDFSSDTLKSITFPKNLKKIKGHYGEGFSYCRNLTEIIIPDEIKQIEFDWCSFKGTHLTLKTQAKLKELGYTGSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JQ7</accession>
    <name>QUEA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="1">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queA</name>
        <name type="ordered locus">TDE_2451</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973050.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957235.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JQ7"/>
    <dbReference type="SMR" id="Q73JQ7"/>
    <dbReference type="STRING" id="243275.TDE_2451"/>
    <dbReference type="EnsemblBacteria" id="AAS12969">
        <property type="protein sequence ID" value="AAS12969"/>
        <property type="gene ID" value="TDE_2451"/>
    </dbReference>
    <dbReference type="GeneID" id="2739636"/>
    <dbReference type="KEGG" id="tde:TDE_2451"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2319"/>
    <dbReference type="eggNOG" id="COG0809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039110_1_0_12"/>
    <dbReference type="OMA" id="YSYGDGM"/>
    <dbReference type="OrthoDB" id="368001at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000231389" description="S-adenosylmethionine:tRNA ribosyltransferase-isomerase">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <sequence length="347" mass="40043" checksum="85611E313DD7AB99" modified="2004-07-05" version="1">MLTKEFNFDLPEELIAQSPSEKRGGDRLLILDKQSGKLEDRLFTELPEILPKNALMVFNNSKVRHARIYAKSKTNAVCEFLMINPMRDSDGSLWQVMAKKAKRQKPGKTFLFEDGTEAEIIESEIPLESEFRCMKFNRVIDDEWLDKYGHMPLPPYIHRKDTQEDADRYQTVYAEIYGSIAAPTAGLHFTQEVLSKIRDKGIDIEYVTLHVGLGTFLPVRAEKIEDHKMHTEHFFISEKTAQAVEKAKKEGRPIIAVGTTTVRTLESAWDEKRKELKWGNQSTDIFIYPSYKFKLIDKLFTNFHTPESSLVMLVSALAGKENIFKAYRHAVEEKYKFFSYGDAMLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JT7</accession>
    <name>Q73JT7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973096.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667427.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2498"/>
    <dbReference type="EnsemblBacteria" id="AAS13015">
        <property type="protein sequence ID" value="AAS13015"/>
        <property type="gene ID" value="TDE_2498"/>
    </dbReference>
    <dbReference type="GeneID" id="2741471"/>
    <dbReference type="KEGG" id="tde:TDE_2498"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2365"/>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066633_0_0_12"/>
    <dbReference type="OMA" id="CGIDLMT"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045761">
        <property type="entry name" value="ODP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19583">
        <property type="entry name" value="ODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="34"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="255" mass="28865" checksum="02BD8E8BCE8F5BFF" modified="2004-07-05" version="1">MENNGIDGVVLYEDADHKFIWLGSESKQRKGAVQTMQYLIVDRGRGVLLDPGGVHLFSRVVTAISRFISVDKIDTIFFSHQDPDVSSGIALWLGITKAKIYISSLWVRFMPHFGIVDISRMVPIPDKGMSISLPSGSNMKCIPSHFMHSPGQFGLYDERSRILFSGDIGAAVFDDDNETTFVEDFEKHLPLIEGFHVRYMASNKIVSKWVEYVRRLNPLMIAPQHGAIYKDEQVNNFLNWLSGLKCGTDYIENLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JY8</accession>
    <name>Q73JY8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973149.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680516.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2551"/>
    <dbReference type="EnsemblBacteria" id="AAS13068">
        <property type="protein sequence ID" value="AAS13068"/>
        <property type="gene ID" value="TDE_2551"/>
    </dbReference>
    <dbReference type="GeneID" id="2739916"/>
    <dbReference type="KEGG" id="tde:TDE_2551"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2411"/>
    <dbReference type="eggNOG" id="ENOG50325JJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_794405_0_0_12"/>
    <dbReference type="OMA" id="NNENALW"/>
    <dbReference type="OrthoDB" id="834480at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021243">
        <property type="entry name" value="DUF2804"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10974">
        <property type="entry name" value="DUF2804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="356" mass="40902" checksum="3D07DACED69364DA" modified="2004-07-05" version="1">MANDNLYTRKIEPAPDKPVQNGKSNFGTFSGCFKKFDIRGLYRVFGNIPLPRIITNGRISGTMRFLFCDDEIIGEIAFFSCYIFSFMETTFWVRKTQQKYAYRQYLPGGFIHIPKHIRYSVTACRKSYRYARIFSRLSHGKLHADFDFSARDSRPSCEGRLDLDIRDKEALDFSCVIPNYVSRRCMAMYMQTGTVKGWVSLGYNEDIQLKKETAVGVFDVRKSYTGFRSKRTLVNGLGKLGDKSLVFYLANSIAADSNRYNDNMILYDGKRTPLPPVKITRPFGIMGKWIIQDTESMVDLVFLPVSKNYKRVNAAVFRTEYSTVYGHFEGTLLTADGEELKLKSFPGIAKKYNIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JZ5</accession>
    <name>Q73JZ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973142.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2544"/>
    <dbReference type="EnsemblBacteria" id="AAS13061">
        <property type="protein sequence ID" value="AAS13061"/>
        <property type="gene ID" value="TDE_2544"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2544"/>
    <dbReference type="HOGENOM" id="CLU_3384328_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="33" mass="3662" checksum="57A217090B804174" modified="2004-07-05" version="1">MRLTSASLFPYKNAGNKQPETNLLILSVLCLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K08</accession>
    <name>Q73K08_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973155.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2557"/>
    <dbReference type="EnsemblBacteria" id="AAS13074">
        <property type="protein sequence ID" value="AAS13074"/>
        <property type="gene ID" value="TDE_2557"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2557"/>
    <dbReference type="HOGENOM" id="CLU_3206552_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="45" mass="5088" checksum="EF0AFDE5E11462A5" modified="2004-07-05" version="1">MDILFKAFKKKSAILKNFASAYGAILCCQALDNFLNLTLFSQSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K42</accession>
    <name>Q73K42_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972979.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680305.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2380"/>
    <dbReference type="EnsemblBacteria" id="AAS12898">
        <property type="protein sequence ID" value="AAS12898"/>
        <property type="gene ID" value="TDE_2380"/>
    </dbReference>
    <dbReference type="GeneID" id="2740682"/>
    <dbReference type="KEGG" id="tde:TDE_2380"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2248"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059003_0_0_12"/>
    <dbReference type="OrthoDB" id="1560752at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="387" mass="43648" checksum="0DFF3D297886B5B8" modified="2004-07-05" version="1">MKEFVSLCLAQLKRILKNITNASMLIIFPFAMIILIFVIRFVLDPKDTDNSETKKTDYTVQMGEVNYFVDDTGDLWKNFFAGSESTVHPENREEELAKVKEKLATGKIPGLIIIPKDFSEKISKNEKPELEILKTEESIILDNRVQALNLSINAYLMDNFIKSSGLAENGENLLNNNINIVFKTPNNKNIISLGLKIMTLVVLYMIIFGSTAIVTDLIKFRETKMLARAIISPNSEFKIVGSFLLAFVFIQVVVNMIVFISATIIFKLEITGLPLIFLAVVSTSFFALSIAILIARIFKKESQLALASNITSLLTIVLFFLAIISVMPFVSIPPVFKNISMFSPLYWLLEMLDKEKLFPNILIVWAMTAAIFTAGSWKIKEFNNEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K57</accession>
    <name>Q73K57_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">High-affinity branched-chain amino acid ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972964.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674209.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2365"/>
    <dbReference type="EnsemblBacteria" id="AAS12883">
        <property type="protein sequence ID" value="AAS12883"/>
        <property type="gene ID" value="TDE_2365"/>
    </dbReference>
    <dbReference type="GeneID" id="2739974"/>
    <dbReference type="KEGG" id="tde:TDE_2365"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2233"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_1_2_12"/>
    <dbReference type="OMA" id="VFWYKLQ"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="339" mass="37434" checksum="84ACE1D02529A99B" modified="2004-07-05" version="1">MRKKSIILDKMIKKIAKNQIFVLIILAVLAISFPIFVDNNYYLGIAIMFFIYSILTLSLNLVTGYVGFTLLGQAAFFGLGAYVAAILGTRFQVDFIIGCIAASLFAGIFGAMLALPTLRIRGRYFAIVTLGFSEIMRMIELNWMEMTRGPQGISRIPGIVIFGKEFDSYRFKYYVGLVLLIFALYIINSILNSKHGRAVRAIKDDDLAAGAIGVNVYKYTVIIFSISAGIAGMAGAYYAHYMSFIDPNAFNFEQSILILSMAIFGGLGSLPGSILGALALTILPEALRFLSDYRQIIYGLILVLIVIFKPSGVMGKINFERIRSIANMEKEDLNVESNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K58</accession>
    <name>Q73K58_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High-affinity branched-chain amino acid ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2364</name>
    </gene>
    <organism evidence="5 6">
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972963.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680286.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2364"/>
    <dbReference type="EnsemblBacteria" id="AAS12882">
        <property type="protein sequence ID" value="AAS12882"/>
        <property type="gene ID" value="TDE_2364"/>
    </dbReference>
    <dbReference type="GeneID" id="2739973"/>
    <dbReference type="KEGG" id="tde:TDE_2364"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2232"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="EHDMRFI"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="256" mass="28748" checksum="29707552D84AD96D" modified="2004-07-05" version="1">MSNPILKITDVTKRFGGIMAVDNINMSVYLGKIQGIIGPNGAGKTTLFNLISGIYKPTLGSIHFCGEDITNLKPHRINEKGIVRTFQNIRLFKNMTILDNVMVGCHNKENEDILDALFKTKRHKAEEQKNKNKALSLLDRVGLIHLRYEMPDSLPYGLRRKLEIARALASNPKLLMLDEPAAGMNEQETIELTEFIQSLKSKDMAIMLIEHDMKLVMSLSDSVYVINHGLKIAEDSPEEIVKDKAVINAYLGEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KC0</accession>
    <name>Q73KC0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Galactokinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972898.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667821.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2298"/>
    <dbReference type="EnsemblBacteria" id="AAS12817">
        <property type="protein sequence ID" value="AAS12817"/>
        <property type="gene ID" value="TDE_2298"/>
    </dbReference>
    <dbReference type="GeneID" id="2740263"/>
    <dbReference type="KEGG" id="tde:TDE_2298"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2168"/>
    <dbReference type="eggNOG" id="COG0153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_2_1_12"/>
    <dbReference type="OMA" id="KYRKEDR"/>
    <dbReference type="OrthoDB" id="1388391at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="2 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="6">
        <location>
            <begin position="8"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="5">
        <location>
            <begin position="278"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="384" mass="43846" checksum="9F4C60C395BF8D79" modified="2004-07-05" version="1">MQKIVTFHIDEYGDEPEVCAAAPGRFHLLGEHTWFAQGNTLSMSINHYLYACASRRSDNNFRLFSISLNERKKISYSGLRYKREDRWANAVKAVISAFNDFGHHVSGLNFTILSEIPADAGLGTPNALKTATALILRKMFAPKLTKSDLVDILEHANVQHLNTYAHRADILCALFAKSNHCVRTDHRKKTADIYPFPIEGHSIILTDSRVPRIIAREELTARLDECVEAYELVKKQPDMPKNMMHLTEKMLEEIDIPESVRRRVTYIIRESLSVDEAVDALKRKDNIMLSRILNRSHDGLRDRFEISCPELDWLVKRSLEFMEPSVTNLVCSRMTGKGFGGCTYTILRDEDAKAYIEKVGDYERIFGFKPLIYKAKPTGSARTF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2016-04-13" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KL7</accession>
    <name>MEGL_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-methionine gamma-lyase</fullName>
            <shortName evidence="4">MGL</shortName>
            <ecNumber evidence="2">4.4.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Homocysteine desulfhydrase</fullName>
            <ecNumber evidence="2">4.4.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">L-methionine-alpha-deamino-gamma-mercaptomethane-lyase</fullName>
            <shortName evidence="3">METase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">megL</name>
        <name evidence="6" type="ordered locus">TDE_2200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Biochem. Biophys. Res. Commun." volume="331" first="127" last="131">
            <title>High production of methyl mercaptan by L-methionine-alpha-deamino-gamma-mercaptomethane lyase from Treponema denticola.</title>
            <authorList>
                <person name="Fukamachi H."/>
                <person name="Nakano Y."/>
                <person name="Okano S."/>
                <person name="Shibata Y."/>
                <person name="Abiko Y."/>
                <person name="Yamashita Y."/>
            </authorList>
            <dbReference type="PubMed" id="15845368"/>
            <dbReference type="DOI" id="10.1016/j.bbrc.2005.03.139"/>
        </citation>
        <scope>IDENTIFICATION BY MASS SPECTROMETRY</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the alpha,gamma-elimination of L-methionine to produce methanethiol, 2-oxobutanoate and ammonia; methanethiol (methyl mercaptan) is considered to be one of the main causes of the oral malodor associated with periodontitis and may also play a role in the pathogenicity of T.denticola. Also displays homocysteine desulfhydrase activity, degrading homocysteine to produce hydrogen sulfide, 2-oxobutanoate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + L-methionine = 2-oxobutanoate + methanethiol + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23800"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="EC" id="4.4.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + L-homocysteine = 2-oxobutanoate + H(+) + hydrogen sulfide + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14501"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">0.55 mM for L-methionine</KM>
            <Vmax evidence="2">36.6 umol/min/mg enzyme with L-methionine as substrate</Vmax>
        </kinetics>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer; dimer of active dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family. L-methionine gamma-lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.11" evidence="2"/>
    <dbReference type="EC" id="4.4.1.2" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972801.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674490.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KL7"/>
    <dbReference type="SMR" id="Q73KL7"/>
    <dbReference type="STRING" id="243275.TDE_2200"/>
    <dbReference type="PRIDE" id="Q73KL7"/>
    <dbReference type="EnsemblBacteria" id="AAS12720">
        <property type="protein sequence ID" value="AAS12720"/>
        <property type="gene ID" value="TDE_2200"/>
    </dbReference>
    <dbReference type="GeneID" id="2739476"/>
    <dbReference type="KEGG" id="tde:TDE_2200"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2076"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_3_12"/>
    <dbReference type="OMA" id="YGGMITF"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="BRENDA" id="4.4.1.11">
        <property type="organism ID" value="6426"/>
    </dbReference>
    <dbReference type="SABIO-RK" id="Q73KL7"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047982">
        <property type="term" value="F:homocysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018826">
        <property type="term" value="F:methionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006237">
        <property type="entry name" value="L-Met_gamma_lys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01328">
        <property type="entry name" value="met_gam_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000436015" description="L-methionine gamma-lyase">
        <location>
            <begin position="1"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="89"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P13254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="15845368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="15845368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="15845368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="401" mass="43488" checksum="4E0CF48F2603283E" modified="2004-07-05" version="1">MNRKELEKLGFASKQIHAGSIKNKYGALATPIYQTSTFAFDSAEQGGRRFALEEEGYIYTRLGNPTTTVVEEKLACLENGEACMSASSGIGAVTSCIWSIVNAGDHIVAGKTLYGCTFAFLNHGLSRFGVDVTFVDTRDPENVKKALKPNTKIVYLETPANPNMYLCDIAAVSKIAHAHNPECKVIVDNTYMTPYLQRPLDLGADVVLHSATKYLNGHGDVIAGFVVGKKEFIDQVRFVGVKDMTGSTLGPFEAYLIGRGMKTLDIRMEKHCANAQKVAEFLEKHPAVESIAFPGLKSFPQYELAKKQMKLCGAMIAFTVKGGLEAGKTLINSVKFATIAVSLGDAETLIQHPASMTHSPYTPEERAASDIAEGLVRLSVGLEDAEDIIADLKQALDKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KP1</accession>
    <name>Q73KP1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Site-specific recombinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972777.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680024.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2176"/>
    <dbReference type="EnsemblBacteria" id="AAS12696">
        <property type="protein sequence ID" value="AAS12696"/>
        <property type="gene ID" value="TDE_2176"/>
    </dbReference>
    <dbReference type="GeneID" id="2740198"/>
    <dbReference type="KEGG" id="tde:TDE_2176"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2054"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_18_2_12"/>
    <dbReference type="OMA" id="HDVSIPD"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025378">
        <property type="entry name" value="DUF4368"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14287">
        <property type="entry name" value="DUF4368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Recombinase" evidence="2">
        <location>
            <begin position="166"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="543"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="612" mass="72643" checksum="DDBF943FC48E6D5A" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KP3</accession>
    <name>Q73KP3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BAAT_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972775.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680020.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2174"/>
    <dbReference type="ESTHER" id="trede-q73kp3">
        <property type="family name" value="Acyl-CoA_Thioesterase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12694">
        <property type="protein sequence ID" value="AAS12694"/>
        <property type="gene ID" value="TDE_2174"/>
    </dbReference>
    <dbReference type="GeneID" id="2740196"/>
    <dbReference type="KEGG" id="tde:TDE_2174"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2052"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_896421_0_0_12"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAAT_C" evidence="1">
        <location>
            <begin position="71"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="311" mass="35442" checksum="8F2738534B5625A8" modified="2004-07-05" version="1">MKKEIKTIEKDGYNGVYWPNPNGSKYCMIAMLGDDTKDMMAKGGVKWLQKKGLNVLTMSPAPKDYGHHNYPLERFEKALAFLKTMGNEEIGIMGASTTGMLALVAASYFSEITLTIAISPSDFVMEGFYQDGKDGAHERPGDGESSVSYHGKPLPYLPYAYRHPEYWQKISEETKRRGAMVASRDLFDESEKRHPVQEAEKIKVENIKGRILLIGAEDDVLWDTCKYIRRMENRLKERDADNSVVLMTYEHGTHFIFPQTMLTGILPVGSGLFISMAFKEAKQYPKECKQTRIEVDERLSEELKQWINSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KQ4</accession>
    <name>Q73KQ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972764.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957169.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2163"/>
    <dbReference type="EnsemblBacteria" id="AAS12683">
        <property type="protein sequence ID" value="AAS12683"/>
        <property type="gene ID" value="TDE_2163"/>
    </dbReference>
    <dbReference type="GeneID" id="2739149"/>
    <dbReference type="KEGG" id="tde:TDE_2163"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2043"/>
    <dbReference type="eggNOG" id="COG2738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084406_0_0_12"/>
    <dbReference type="OMA" id="VQHATAY"/>
    <dbReference type="OrthoDB" id="1656873at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007395">
        <property type="entry name" value="Zn_peptidase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36434">
        <property type="entry name" value="PTHR36434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04298">
        <property type="entry name" value="Zn_peptidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="226" mass="24780" checksum="A713A5411752163B" modified="2004-07-05" version="1">MYFDYYYLVLVVPTLLLSLYAQFKVKSAFSKYSQVQTMRKISGKEAAALLLRSNSISNVSIQRIGGSLSDHYDPSHKVLRLSEPVYDKTSIAAVGVAAHETGHAIQDKEKYAPLVLRSTLVPVANIGSTAGPYLALAGIIFRMNLLLNIGIILFACAVLFYLITLPVEIDASRRALKVLEHNAVLNQEELKGAKKVLSAAALTYVASALTAMANLLRLILISRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KS9</accession>
    <name>Q73KS9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972739.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679953.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2138"/>
    <dbReference type="EnsemblBacteria" id="AAS12658">
        <property type="protein sequence ID" value="AAS12658"/>
        <property type="gene ID" value="TDE_2138"/>
    </dbReference>
    <dbReference type="GeneID" id="2739397"/>
    <dbReference type="KEGG" id="tde:TDE_2138"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2019"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1937203_0_0_12"/>
    <dbReference type="OrthoDB" id="1360387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="127" mass="14306" checksum="61CCC930BD541332" modified="2004-07-05" version="1">MNIAEFIKAAKKNDIELIKTYLQNGFDINTQDKDGFTAVMEAAEFGYKDLFWFLIEKGADVLIKADYNFSIVHAVGLGGDKKMLDYVISKGARLDEKVTGGEQDGMTIRDYALLAKNDEVYRELKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KU0</accession>
    <name>Q73KU0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VapC protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972728.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679941.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2127"/>
    <dbReference type="EnsemblBacteria" id="AAS12647">
        <property type="protein sequence ID" value="AAS12647"/>
        <property type="gene ID" value="TDE_2127"/>
    </dbReference>
    <dbReference type="GeneID" id="2739386"/>
    <dbReference type="KEGG" id="tde:TDE_2127"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2010"/>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_5_3_12"/>
    <dbReference type="OMA" id="NTAEFTR"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="133" mass="15455" checksum="DC0C0CE9149C1AA0" modified="2004-07-05" version="1">MYYLDTNICIYFINGKYQSLKNKILSIPPSKIRLPSIVKAELLLGAYKSRKKKDNLKRLEVFFKEFEVEPFSDHTAYTYADIRSKLEKSGTLIGPNDLLIASIVLYNNGTLVTNNTKEFKRIKTLKLENWVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KV3</accession>
    <name>Q73KV3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2114</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972715.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679925.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2114"/>
    <dbReference type="EnsemblBacteria" id="AAS12634">
        <property type="protein sequence ID" value="AAS12634"/>
        <property type="gene ID" value="TDE_2114"/>
    </dbReference>
    <dbReference type="GeneID" id="2739373"/>
    <dbReference type="KEGG" id="tde:TDE_2114"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1997"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="GETVFFY"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="261" mass="29216" checksum="88FF7224DA618F02" modified="2004-07-05" version="1">MLKVQNLSKYYGSKKTQVVGCKNISFELKTGEITSLLGLNGAGKSSIINCISGYYTPDEGDAFIDSYSILTDGLEAKKLLGILYEQNPLYSNMTVHDFLYFAGQMHGIEKDRLDAALDEVIDFCEIDEVKNHLIKSLSKGFKQRVGLAQAVLHNPPLIILDEPASGFDSVQVKDFEKKILHIAKEKTILICTHDLRQAAELCSNHILLNKGEIIAIGNLLEIKEQLETEGCDFDSEINYTVLEKAFEFFAGINKNEFRKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KW8</accession>
    <name>Q73KW8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972700.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2099"/>
    <dbReference type="EnsemblBacteria" id="AAS12619">
        <property type="protein sequence ID" value="AAS12619"/>
        <property type="gene ID" value="TDE_2099"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2099"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1982"/>
    <dbReference type="HOGENOM" id="CLU_3298099_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="40" mass="5069" checksum="9EFAB19DFF2DFA28" modified="2004-07-05" version="1">MLHIKLHDKLFKRENFFPFHNYCMKSLQQIVKILKKIKFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KY1</accession>
    <name>Q73KY1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972687.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679886.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2086"/>
    <dbReference type="EnsemblBacteria" id="AAS12606">
        <property type="protein sequence ID" value="AAS12606"/>
        <property type="gene ID" value="TDE_2086"/>
    </dbReference>
    <dbReference type="GeneID" id="2740325"/>
    <dbReference type="KEGG" id="tde:TDE_2086"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1970"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120989_0_0_12"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="172" mass="19977" checksum="ECA297D761AB0AD7" modified="2004-07-05" version="1">MENYYSILNISNNADEDQIKQAYRALAMKYHPDKNPDSKTAEEKFKRISEAYSVLSDPQKRRDYDLSMSSPFSSSGRTYTHDQNTNPFGDDIFSSNWWKNWRNIRSENAKKREKISRSEAFRILIRGIILTIVGLLLFKSIIFLGIFGFLLALSIVTEGVLRIRKGYMAIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KY7</accession>
    <name>Q73KY7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytidylate kinase</fullName>
            <shortName evidence="10">CK</shortName>
            <ecNumber evidence="10">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cytidine monophosphate kinase</fullName>
            <shortName evidence="10">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cmk</name>
        <name evidence="13" type="ordered locus">TDE_2080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bS1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="10"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972681.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679883.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2080"/>
    <dbReference type="EnsemblBacteria" id="AAS12592">
        <property type="protein sequence ID" value="AAS12592"/>
        <property type="gene ID" value="TDE_2080"/>
    </dbReference>
    <dbReference type="GeneID" id="2741207"/>
    <dbReference type="KEGG" id="tde:TDE_2080"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1965"/>
    <dbReference type="eggNOG" id="COG0283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015805_1_1_12"/>
    <dbReference type="OMA" id="SLNEFRY"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:CMP kinase activity"/>
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        <property type="project" value="RHEA"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000110">
        <property type="entry name" value="Ribosomal_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
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    <dbReference type="TIGRFAMs" id="TIGR00717">
        <property type="entry name" value="rpsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="273"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="352"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="443"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="528"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="615"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="702"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="782"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="7"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS12592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="811" mass="90172" checksum="F0C81A6AAF42428B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KY8</accession>
    <name>Q73KY8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54 dependent transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="protein sequence ID" value="AAS12591"/>
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    </dbReference>
    <dbReference type="GeneID" id="2741206"/>
    <dbReference type="KEGG" id="tde:TDE_2079"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1964"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="IQRTYLS"/>
    <dbReference type="OrthoDB" id="123059at2"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
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    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
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        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="195"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="7">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="505" mass="57370" checksum="7BAE962A80220693" modified="2004-07-05" version="1">MSTVESIKRDKLNTLINTSLLINSNYSDLSVLLEKIVESAMDVVEGDAASLLMLEPDGERLRFEIAIGPKGIEAKKMVLDLDGIAGWVIKYNRSAIINDVLSDPRFDPTVQKVTGYKNRNMIAVPMRIKDECIGVIEVLNKREEKDFDSDDLNVLELFATQTAIAYQNAKHYEKSREEIICLQDQLEQDRGYHTFIAKSKVMNEKLELCRNIAASDASVLILGESGVGKELIAEQLHLNSRRVNNPFIRVNCAALPEGLLESELFGHVRGAFTDAISDRKGRFELADKGTIFLDEIGDIPLTLQTKLLRVLQEMAFERVGSNKTLTVDTRIIAATNKNIEELVRQGKFRSDLYYRLNVLPIYIPPLRNRKDDIQELAHFFLKKFSKEVKKPFLGFSPDAEKLINAYSWPGNIRELENAVERACVLGKPPYIEEKDLLLKFESSSFEPEVNYSNPDLKSAVNDFKKSFIVKILNEHKWNQTAAAEKLGIQRTYLSRLIKELEIKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KZ5</accession>
    <name>Q73KZ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.1957"/>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="AAS12584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="100" mass="11478" checksum="4A9C863395860D1E" modified="2004-07-05" version="1">MQEIKEGFIKTSELPVKTLTAEQKAKLNLRGNELYNKKDIAAAERIFITTGYSDGLVRIGDYYANRNEHLKALKFYHLAHNTNKEGILLDKLAEIIRMLI</sequence>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
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                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
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        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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        <location>
            <begin position="238"/>
            <end position="443"/>
        </location>
    </feature>
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            <begin position="454"/>
            <end position="556"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF01078"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13335"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS12509.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="566" mass="62094" checksum="EEB08C022937A6E7" modified="2004-07-05" version="1"> </sequence>
</entry>
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    <accession>Q73L73</accession>
    <name>Q73L73_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">OmpA family protein</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1992</name>
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    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
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                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
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                <person name="Sodergren E."/>
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                <person name="Weinstock G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
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                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
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                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
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                <person name="Gebregeorgis E."/>
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                <person name="Tsegaye G."/>
                <person name="Malek J."/>
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                <person name="Shatsman S."/>
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                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
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                <person name="Sodergren E."/>
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                <person name="Weinstock G.M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_002669815.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1991"/>
    <dbReference type="EnsemblBacteria" id="AAS12505">
        <property type="protein sequence ID" value="AAS12505"/>
        <property type="gene ID" value="TDE_1991"/>
    </dbReference>
    <dbReference type="GeneID" id="2740444"/>
    <dbReference type="KEGG" id="tde:TDE_1991"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1880"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071023_2_0_12"/>
    <dbReference type="OMA" id="TFENICI"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="254" mass="29733" checksum="98AD37123CC7D5A6" modified="2004-07-05" version="1">MVKRFEDLTFTDDFMFCKAMQNPDLCKGLIEMILADTIGKIAYISIQHNLKNYEQAKSVRFDVLVQTENGNLYDVEMQVSNEKNIPKRMRFYQAAIDISFLDKGNFYNDLNDSFIIFICLFDVIGKNRPVYTFENICIEDKNISLQDGTKKVIINSEAFKNTEDKDLKEFLEYLKTGKPNNEFTRRIEEVIQTIKENEQARQEYRLMSTFEMDARYKGFSEGLKQTAKNMKMEKLDISLIKKITGLSESEIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L76</accession>
    <name>Q73L76_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972592.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679729.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1989"/>
    <dbReference type="EnsemblBacteria" id="AAS12503">
        <property type="protein sequence ID" value="AAS12503"/>
        <property type="gene ID" value="TDE_1989"/>
    </dbReference>
    <dbReference type="GeneID" id="2740442"/>
    <dbReference type="KEGG" id="tde:TDE_1989"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1878"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1102396_0_0_12"/>
    <dbReference type="OMA" id="HEHAMIP"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="74"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="252" mass="28183" checksum="5C71E3AF591A9D36" modified="2004-07-05" version="1">MGALIAILCCLVALSWRAALIGVCHSVYRRGCDWVNSEVIVGPAPRLLFAIFKQYIGFRFEGDYSLTDQLPEQYLVISNHQSILDIVVHMNYYNGTRLRFVAKEELGHNVPLVSPMLKSGKHCLVKRTGSPTQAMKAVDKFADHVVKNNLIPVIFPEGSRSKDGNLKTFHAAGFRRFLNAAPMPVAVCAVDGGWKISSLTRMAKNLKGGAYRIKLLKIYDAPKTKEEQIKILEEGKALIQAQLDEWRKADKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L79</accession>
    <name>Q73L79_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylate cyclase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972589.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679721.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1986"/>
    <dbReference type="EnsemblBacteria" id="AAS12500">
        <property type="protein sequence ID" value="AAS12500"/>
        <property type="gene ID" value="TDE_1986"/>
    </dbReference>
    <dbReference type="GeneID" id="2740439"/>
    <dbReference type="KEGG" id="tde:TDE_1986"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1875"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016487_0_0_12"/>
    <dbReference type="OMA" id="RIGCGIN"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="317"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="401"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="636" mass="70089" checksum="BE75F9E78DEF69EB" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LA2</accession>
    <name>Q73LA2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenocysteine-specific translation elongation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">selB</name>
        <name evidence="3" type="ordered locus">TDE_1963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972566.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679687.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1963"/>
    <dbReference type="EnsemblBacteria" id="AAS12477">
        <property type="protein sequence ID" value="AAS12477"/>
        <property type="gene ID" value="TDE_1963"/>
    </dbReference>
    <dbReference type="GeneID" id="2741526"/>
    <dbReference type="KEGG" id="tde:TDE_1963"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1855"/>
    <dbReference type="eggNOG" id="COG3276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023030_3_1_12"/>
    <dbReference type="OMA" id="WKERGIL"/>
    <dbReference type="OrthoDB" id="244339at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015191">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004535">
        <property type="entry name" value="Transl_elong_SelB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09107">
        <property type="entry name" value="SelB-wing_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00475">
        <property type="entry name" value="selB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="590" mass="65998" checksum="C6C2AD086396BBED" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LB6</accession>
    <name>Q73LB6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1949</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972552.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1949"/>
    <dbReference type="EnsemblBacteria" id="AAS12463">
        <property type="protein sequence ID" value="AAS12463"/>
        <property type="gene ID" value="TDE_1949"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1949"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1841"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_12"/>
    <dbReference type="OMA" id="VGREMSH"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="258"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="507" mass="55829" checksum="95CBC100633B3A27" modified="2004-07-05" version="1">MSHSDYVIEMRNIRKEFPGIVANDDISLCVKQGEIHAILGENGAGKSTLMSILFGLYHADRGEIYVKGNKVKINSPNDANDLGIGMVHQHFKLIHNFTVTENIILGKEGGFILNEKEAEKRIKELSDKYGLFIEPDALISNITVGMQQRVEILKMLYRNADILIFDEPTAVLTPQEINELMQIMRNLAAEGKAIILITHKLQEILDVADKCTIIRRGKLIDVVDVASTTKNELASKMVGRPVDFKVPKGPSNPGKPILEIKNLNVLKEKKLPAVRDFSLEVRAGEIVGIAGVDGNGQSELVYALSGLMPVESGSILLDGKDITNFSVRKRAESGLGHVPEDRQKHGLILQYSIAENMVIKSYYTQNFQKHGFLNKEKIKSFAQKISEIFDVRSGSGIESKAGNLSGGNQQKAILGREITLDPPLLIAVNPTRGLDVGAIESIHKELVKHRDNGRAVLLISFELDEIFNLSDRIAVMHRGSLSGIVRPEETTAEEVGLMMAGMGGKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LI4</accession>
    <name>Q73LI4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, haloacid dehalogenase-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972482.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1878"/>
    <dbReference type="EnsemblBacteria" id="AAS12393">
        <property type="protein sequence ID" value="AAS12393"/>
        <property type="gene ID" value="TDE_1878"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1878"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1779"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_3_12"/>
    <dbReference type="OMA" id="TEACTES"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="261" mass="29907" checksum="C8CF8C281F2CD4B7" modified="2004-07-05" version="1">MPILPTEACTESLKGNRLNPMKSPAMIIFDYGNTLIYEKELDLERAYKALYAQIHKNPDKIDFITFYKKGMAIFERVKSRALQNDVEIHTHNFYNCLFQILNVEFNLSYTELEILFWEALAPCRAMPNIEKLLLFLEAKNIRTAVISNIAFSEKAVIARINKYLPQNKFEFIIASSEYGFRKPDCLLFEAALKKACLSADEVWYCGDNPRADVIGSAAIGIKPILYTSSLACPYDNESHISPDFEFTKISDWDELIELIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LL7</accession>
    <name>Q73LL7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972449.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669605.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1845"/>
    <dbReference type="EnsemblBacteria" id="AAS12360">
        <property type="protein sequence ID" value="AAS12360"/>
        <property type="gene ID" value="TDE_1845"/>
    </dbReference>
    <dbReference type="GeneID" id="2740507"/>
    <dbReference type="KEGG" id="tde:TDE_1845"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1751"/>
    <dbReference type="eggNOG" id="ENOG5031EMM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162052_0_0_12"/>
    <dbReference type="OMA" id="VWESYLE"/>
    <dbReference type="OrthoDB" id="1677660at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="122" mass="14385" checksum="6D5ECFA0DA2964A0" modified="2004-07-05" version="1">MFKIRMGIPEMKQIWENLEKKYNSNTLSKAEKELFKKLINCFKKLSNDPHYPGLQSHEIESLTRRYKIKVWESYLENNKPAAGRIFWVYGPNRGDITIIGLEPHPNDKKNAYNKITLSSIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LU1</accession>
    <name>Q73LU1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972375.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679520.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12286">
        <property type="protein sequence ID" value="AAS12286"/>
        <property type="gene ID" value="TDE_1771"/>
    </dbReference>
    <dbReference type="GeneID" id="2741215"/>
    <dbReference type="KEGG" id="tde:TDE_1771"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1689"/>
    <dbReference type="eggNOG" id="ENOG5030VIY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1073397_0_0_12"/>
    <dbReference type="OrthoDB" id="2108745at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="259" mass="29961" checksum="12FCC3DAF04600D3" modified="2004-07-05" version="1">MKRLIASIVIIASIILLSSFIGYLKSGYTLFNGVYNSDILGSYSTFIGSILGPLTSIVASVLFFYSLKEQQKSINLQTKELLEIQESNNINNDNENFMLLLRELNEINNSLDIVIQYNHETTSAKGYTKLDVIKQLKIYQLNPSLSLKCDSNKGNEKPNQKEYLFCKENDTIVYEGNFCRVVKRPKNEIDYFQELERRIWILTNSLIEVINNSKNKEIQKKVFVSNLNFTYLDVILGIFNQRNTHPDDKIIFEMIELIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LX3</accession>
    <name>Q73LX3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FemAB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FemABX family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972343.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679457.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1739"/>
    <dbReference type="EnsemblBacteria" id="AAS12254">
        <property type="protein sequence ID" value="AAS12254"/>
        <property type="gene ID" value="TDE_1739"/>
    </dbReference>
    <dbReference type="GeneID" id="2739197"/>
    <dbReference type="KEGG" id="tde:TDE_1739"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1662"/>
    <dbReference type="eggNOG" id="COG2348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048411_0_1_12"/>
    <dbReference type="OMA" id="FGLIQFK"/>
    <dbReference type="OrthoDB" id="891566at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016755">
        <property type="term" value="F:aminoacyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003447">
        <property type="entry name" value="FEMABX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02388">
        <property type="entry name" value="FemAB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51191">
        <property type="entry name" value="FEMABX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="354" mass="41498" checksum="271DBBB50DB47095" modified="2004-07-05" version="1">MKETKFLTDEYKEEFDKLVSHPIQSWVWGDFKKSMGAVPERIGFFEDGKLKNGIQIIFSKIPKTNYTVGIASKTIMPEQEHIEALKEAAKKHRAVFIKLEPDVFSPVQKDNSLEETSSDAGFLEAPIEDKKKILLKNGAKNGKPFFEKYNFLLNIEKTEEDLLASFHSKTRYNIRLAEKKGVSIIEKSTEEGMEDYIRLMEETTKRQGFFNHNGEYFRRMFKIFPKDTLRIFEAVYGDEVLTAWILFKFNGKLYYPYGASSNSHRELMPNNLIMWKAIQYGKKLNCSVFDLWGCLGPNPDTENSWYGFHKFKAGYNPQLVEYIGTFDFVYKPFMYKLFNLADKIRWIILKNKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LY1</accession>
    <name>Q73LY1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972335.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957028.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1731"/>
    <dbReference type="TCDB" id="2.A.1.84.1">
        <property type="family name" value="the major facilitator superfamily (mfs)"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12246">
        <property type="protein sequence ID" value="AAS12246"/>
        <property type="gene ID" value="TDE_1731"/>
    </dbReference>
    <dbReference type="GeneID" id="2739189"/>
    <dbReference type="KEGG" id="tde:TDE_1731"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1655"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046709_0_0_12"/>
    <dbReference type="OMA" id="MMSGFML"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="467" mass="51391" checksum="00BDC77E8B2E6493" modified="2004-07-05" version="1">MLKNTDLKKYALIGTKRFWFLMWGLGLAGQLCWNIENQWFNTFVYAKIAKDSSIVTLMVITSALVTTFSTFLFGTLSDRIGSRRRFVSIGYIVWGLTTILFGLTEFVGRGQVGTGAKVSVWAAVLVILADDFMSFFGSMGNDSGYNAWSNDMTTDKNRGQVGAVLAIQPVIGTIVGTVLGGLLIGAENNYQRLFWSMGLFVIGTGLISLFLLKDAPDLKPHKEGSFGKQFAAIFKAEGFFSHKELMLACITTAVFFISFNVYFVHMGNWMIYRMGFDAARMGIIQGLSLLAASLSVIPAIGLINKSRTPRLAAFAIILNSLGLCILSLFIKPASVNPDAVFSLKNISLFLSVFLAGTGQILVTQSMTMWVKELYPETSRGQFEGMRILFFVLTPMIIGTIIGNFLVKNGAGSVVNEFGITENIPVESIYVCGAVLALCAFIPLYFASKLYNKRKNNEPKDTESYEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M22</accession>
    <name>Q73M22_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972293.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669374.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1689"/>
    <dbReference type="EnsemblBacteria" id="AAS12204">
        <property type="protein sequence ID" value="AAS12204"/>
        <property type="gene ID" value="TDE_1689"/>
    </dbReference>
    <dbReference type="GeneID" id="2740144"/>
    <dbReference type="KEGG" id="tde:TDE_1689"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1616"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="PVMFMDE"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="252" mass="27443" checksum="B42D23C710CC562A" modified="2004-07-05" version="1">MIEISNVSKAYGSSKTKAVDCISVNVKNGEIFGFLGPNGAGKTTTIKMITGVLNPDSGSIIVDGVNIAEDPMEAKRRIGYVTDNPELFSQLKAAEYLNFIGDVYGVSADVRQERIEKYTKLFGINDALNGSIGSFSHGMKQKLLVTGSLLSDPPVWILDEPMVGLDPKSAFSLKEIMRERADAGKVVFFSTHVMEVAEKLCDRLAIINAGKIMFEGSLQELREKRGENASLEKLFLELVDDKPSFNLGNGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M44</accession>
    <name>Q73M44_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972271.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12182">
        <property type="protein sequence ID" value="AAS12182"/>
        <property type="gene ID" value="TDE_1666"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1666"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1592"/>
    <dbReference type="HOGENOM" id="CLU_076102_0_0_12"/>
    <dbReference type="OrthoDB" id="1834280at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="231" mass="27100" checksum="7D5DEC3768DEE34C" modified="2004-07-05" version="1">MKPANILGCLNVKIVYLPFINFFSGTTISTGWAYPSLNFYGLAENKNVNNLQVIKPLYFSKFFIDLNAGLELYFDLNSKIKNEWSGLILKTRHIISYKDIVPQTNEDFFFFDNDLGENRNGARYTGTYSIEYNMPLYLNTIRVELISHKNLYKPLPFTKNKAEQLWTFELKNELFFKPSEKIRIKLQAVWKTAPIYYNYKDEAHFTQKIINSKKKIGMFFESVAISLIFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MA2</accession>
    <name>Q73MA2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MutT/nudix family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972213.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679290.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1607"/>
    <dbReference type="EnsemblBacteria" id="AAS12124">
        <property type="protein sequence ID" value="AAS12124"/>
        <property type="gene ID" value="TDE_1607"/>
    </dbReference>
    <dbReference type="GeneID" id="2740848"/>
    <dbReference type="KEGG" id="tde:TDE_1607"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1536"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1538155_0_0_12"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="174" mass="20476" checksum="E173A7A49CD0088A" modified="2004-07-05" version="1">MNNILEIELQDTEWEFTYIDHDREIVRAIVIDDYENYYFVKVHRDDDFGKVTLIETAGGGVEPNEDLEDAIRRELKEELGVEVDILSKIGIVSDYYNLIHRHNLNNYYLCRVKSFGDKNMTQTEVEDFHLSTLKLSYKEAIDKYNKYSNSRLGKLIANRELPILMKAKELISDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MB1</accession>
    <name>Q73MB1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1598</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972204.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679275.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1598"/>
    <dbReference type="EnsemblBacteria" id="AAS12115">
        <property type="protein sequence ID" value="AAS12115"/>
        <property type="gene ID" value="TDE_1598"/>
    </dbReference>
    <dbReference type="GeneID" id="2739795"/>
    <dbReference type="KEGG" id="tde:TDE_1598"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1528"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_12"/>
    <dbReference type="OMA" id="TITAYEC"/>
    <dbReference type="OrthoDB" id="870493at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="271"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="304"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="502" mass="56125" checksum="FB1BEEC6FEA7EC62" modified="2004-07-05" version="1">MADSIVDFDDVSFSYGTQTEGSLKHINLKIEEGECIVLTGQSGCGKTTIMRLINGLIPHFFEGSLTGCVKILGKDTKTTSVGELGRNIASIFQNPRSQFFTTNTTAEAAFACENYGIERAEMIKGVDNAFYDFDAKCLMNRDMFSLSSGEKQKIAIIAAKTLNPNIYVFDEPSANLDIHAIMQLQEMIRKLKEAGHTVIVSEHRLFYLKNLCDRCFIMSNGNIVKELCKSDIENMNTADLTNYKLRTFNIEEIGLNRENKTEYERSDNIKLEIKKLSFSYNHSKKLLDNINITAYAGETIAIIGQNGEGKTTLGKIIAGLLKSAHGRFFLDGKQVKQKELYKSVYFVMQESDYQLYSDSVLSELYVSSGLSSKRNTQKIECIMKLLHIFAYKEKHPWALSGGQKQRVTIAAAMASNKSILIFDEPTSGLDYENMKAVSKAINILSRQGTVNFVISHDLEFLSRVATRAVFIANGTIGGSISLKNNRDFRTVKDFLLRNGVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MF1</accession>
    <name>Q73MF1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972163.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679217.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1557"/>
    <dbReference type="EnsemblBacteria" id="AAS12074">
        <property type="protein sequence ID" value="AAS12074"/>
        <property type="gene ID" value="TDE_1557"/>
    </dbReference>
    <dbReference type="GeneID" id="2739307"/>
    <dbReference type="KEGG" id="tde:TDE_1557"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1493"/>
    <dbReference type="eggNOG" id="ENOG502ZIZV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184612_0_0_12"/>
    <dbReference type="OMA" id="TRMEDDE"/>
    <dbReference type="OrthoDB" id="1519645at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="234" mass="26637" checksum="F464B38C563B8BF1" modified="2004-07-05" version="1">MKKIKKVIILIIIFVITGCVNPYNRIRDGESGIFEEGNDLEGNEDEEGGTNPFEDKLFKKEGEKIILKTNNAKYWGVRGYTLWKFLGKEINKKEPSIKVVKKEGASEAGYGLVCYSTKTEAGQKKYRMLVILIHVDGKYSIGYVVNGLYKHIAWKKESKELNKGYGIENSISVKKEGKKIEIYFNDESYLRKPSYTINDSSEYLLGEGEAGLIGVVSAKDKFPDDFVWIEYKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MF7</accession>
    <name>Q73MF7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoate--protein ligase</fullName>
            <ecNumber evidence="4">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_1551</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972157.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679211.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1551"/>
    <dbReference type="EnsemblBacteria" id="AAS12068">
        <property type="protein sequence ID" value="AAS12068"/>
        <property type="gene ID" value="TDE_1551"/>
    </dbReference>
    <dbReference type="GeneID" id="2740913"/>
    <dbReference type="KEGG" id="tde:TDE_1551"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1487"/>
    <dbReference type="eggNOG" id="COG0095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_0_2_12"/>
    <dbReference type="OMA" id="CYLIPYD"/>
    <dbReference type="OrthoDB" id="871298at2"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="PTHR12561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="8">
        <location>
            <begin position="27"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="331" mass="38319" checksum="CF74C79EA9A9141C" modified="2004-07-05" version="1">MKYIVNNSHDPEYNMAFEEYCFRNLPLENEEYVFLWSNSPTILLGKNQNTYQEINEKYINENGIKVVRRITGGGAIYQDLENLNFSFVTKTKGNEKIDFKKYYIPIVNALKKIGVDAELSGRNDVTIEGQKCIGASQSVWQGRVLSDGSILFNVEMEALSKALTVRKEKLESKGVKSVRSRVTNIKPYLKRDITVDQFKDELLKAIFEVENQEPVEYKLSEEELKGVMKIYEERFSRKEWNYGASPKAEYSHYERFPIGSIEVFFNVENMKINSLKIHGDFFGTADKAELEELLNGCEYSESVLTEKLRNTDLTPYFGSLEKKDFIGMFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ML2</accession>
    <name>Q73ML2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smc</name>
        <name evidence="6" type="ordered locus">TDE_1496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972102.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679154.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1496"/>
    <dbReference type="EnsemblBacteria" id="AAS12013">
        <property type="protein sequence ID" value="AAS12013"/>
        <property type="gene ID" value="TDE_1496"/>
    </dbReference>
    <dbReference type="GeneID" id="2739897"/>
    <dbReference type="KEGG" id="tde:TDE_1496"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1435"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_2_12"/>
    <dbReference type="OMA" id="HNKIAME"/>
    <dbReference type="OrthoDB" id="1149850at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="946"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="167"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="304"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="529"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="750"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="951"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="980" mass="111948" checksum="73B9728CDB0B5F66" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MQ9</accession>
    <name>Q73MQ9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">yjeQ</name>
        <name evidence="7" type="synonym">rsgA</name>
        <name evidence="12" type="ordered locus">TDE_1449</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972055.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679106.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1449"/>
    <dbReference type="EnsemblBacteria" id="AAS11966">
        <property type="protein sequence ID" value="AAS11966"/>
        <property type="gene ID" value="TDE_1449"/>
    </dbReference>
    <dbReference type="GeneID" id="2741412"/>
    <dbReference type="KEGG" id="tde:TDE_1449"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1390"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_2_1_12"/>
    <dbReference type="OMA" id="CLVAAYD"/>
    <dbReference type="OrthoDB" id="908180at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04466">
        <property type="entry name" value="S1_YloQ_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031944">
        <property type="entry name" value="RsgA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="S1-like" evidence="9">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="CP-type G" evidence="11">
        <location>
            <begin position="75"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="10">
        <location>
            <begin position="87"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="178"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS11966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="315" mass="35224" checksum="D85340F2634600D1" modified="2004-07-05" version="1">MKGLVLKGSNNIFYVECEDGKFRSCSIKGKVLKDSALYYNPLAAGDFVNLEPDTHSDDEGLITGLIERKNSFLRLNQKLNMPQLLAANIDLLVCVVSAANPPFRPRFVDRVLVQAEIQKIPVLIVINKCDLKILADVRDRIEDWKRLDYKTIEVSAKEGRGMDNLIESLSSKTSALVGQSGVGKSTLLNFIAPDLNLKTSAISDKYDRGTHTTTQGEYFKIKALTSKGKEHSINIIDTPGVRHFAIYGIEPEDTALYFPEMEKLIGSCKFGLSCTHTHELGCAILEALKKGNIHKDRYTSFELIHKELQETVKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MR8</accession>
    <name>Q73MR8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epimerase/dehydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS11956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_002679067.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1439"/>
    <dbReference type="EnsemblBacteria" id="AAS11956">
        <property type="protein sequence ID" value="AAS11956"/>
        <property type="gene ID" value="TDE_1439"/>
    </dbReference>
    <dbReference type="GeneID" id="2741402"/>
    <dbReference type="KEGG" id="tde:TDE_1439"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1380"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_2_12"/>
    <dbReference type="OMA" id="CARTQFK"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="329" mass="37292" checksum="EF16091115B5F3A7" modified="2004-07-05" version="1">MHIAIIGGSGFIGTRLTKRLLASGHTIKILDKQDSKYYPNLRAFADVRDIDSLKKELSSSLDCVINLAAEHRDDVEPKSLYDEVNVDGAENVCKVCSELGIKKIIFTSSVAVYGFAPLNTNETGKINYFNDYGRTKWLAEGKYRAWIENDNENSLTIIRPTVVFGEQNRGNVYNLLRQISSGFFPFVGNGKNKKSMAYVENVAAFIEFSLNNGQGEHLFNYLDKPDFDMNSLANEVYKILGNKNHKIFHWPYWLGYCGGLCFDLLAKISRKKLAISSIRVKKFCADTLFDTINIPKTDFKAPVSLSEGLYNTIKYEFIDKIQDHVFHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MS3</accession>
    <name>Q73MS3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972040.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11951">
        <property type="protein sequence ID" value="AAS11951"/>
        <property type="gene ID" value="TDE_1434"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1434"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1375"/>
    <dbReference type="HOGENOM" id="CLU_2686719_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="74" mass="8336" checksum="A45BFF84D97CDD0A" modified="2004-07-05" version="1">MVFLLPEPFALSLYTATFSLIKAVFATKYNVVIRPITMEKSILPVPGSMYNKRIIMPNVKMGSFIFAAAFYHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MT7</accession>
    <name>Q73MT7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972026.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679028.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1420"/>
    <dbReference type="EnsemblBacteria" id="AAS11937">
        <property type="protein sequence ID" value="AAS11937"/>
        <property type="gene ID" value="TDE_1420"/>
    </dbReference>
    <dbReference type="GeneID" id="2739697"/>
    <dbReference type="KEGG" id="tde:TDE_1420"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1362"/>
    <dbReference type="eggNOG" id="ENOG5030KXI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047564_0_0_12"/>
    <dbReference type="OrthoDB" id="1408633at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="399" mass="46993" checksum="137E269E6E0CFD56" modified="2004-07-05" version="1">MNFSPSPIIIGTSSFAQSGGSAITNILEEFFCFSVLKGGAEFECKFFTENIFALETALKIGNGIDKAAKVFLYNAYQASRDSDYKNNFGPEFLNYTIEYIDSVTENYLGAVHKDYDYTFLDPAEHAIFSKAQRLYNYKYGKRIYEAYEPYQWKPSYIPFGKVYYGNFPNDFYDKTHEYIEKVFAPLYEKNKRYVLADALYSASISTPQELMYYKNSKALIANRDPRDLYVMNKEIYGEWYMPTWNVDRWIEYYRYKRQCIKPQKENNAGNILHLQFESLIYNYEGSLAKIKKFLDLKDSEHIKKGQIFIPEKSKTNTQLFRKYPKYAKDIEKIEKKLPEFCYPYSETQIRHFLPEEIKGENRETLEDIRKTVCIFQKTGKLPFSNKQGAFLFSKLGELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N06</accession>
    <name>Q73N06_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mreC</name>
        <name evidence="7" type="ordered locus">TDE_1350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in formation and maintenance of cell shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971956.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668697.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1350"/>
    <dbReference type="EnsemblBacteria" id="AAS11867">
        <property type="protein sequence ID" value="AAS11867"/>
        <property type="gene ID" value="TDE_1350"/>
    </dbReference>
    <dbReference type="GeneID" id="2739451"/>
    <dbReference type="KEGG" id="tde:TDE_1350"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1298"/>
    <dbReference type="eggNOG" id="COG1792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042663_1_0_12"/>
    <dbReference type="OMA" id="NPFTHRI"/>
    <dbReference type="OrthoDB" id="837894at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038471">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00219">
        <property type="entry name" value="mreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="70"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="287" mass="32072" checksum="2D2F7AB848B84190" modified="2004-07-05" version="1">MKKKLSLKLNLEVFLLILFLLISSVFMAFSGGSFILDFKSMAFSVSAGTEKAVYNVSSFVGESVSSVRELWDLKAKYNELTKQLEKYELLERSNADIKRENNELRTLLKFTDSIQIANIPAEIIGYDPNALYSGMIINRGVKHGVRKDMPVIAFQNGNMALVGKILQVGRGSSMIIPIYDYQCHVAAKVDLVNHRGVVSGQGSEDSPLIMKYIKKRAGDDIKIGDKIITSGFDDSSIFPKNIPIGFVSKIKTHDYETSLELSVNPIIDFSCLEYVFVLDTSKIEKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N72</accession>
    <name>Q73N72_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971890.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678788.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1283"/>
    <dbReference type="EnsemblBacteria" id="AAS11801">
        <property type="protein sequence ID" value="AAS11801"/>
        <property type="gene ID" value="TDE_1283"/>
    </dbReference>
    <dbReference type="GeneID" id="2740576"/>
    <dbReference type="KEGG" id="tde:TDE_1283"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1233"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046536_1_0_12"/>
    <dbReference type="OMA" id="WSFPNFT"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284607" evidence="1">
        <location>
            <begin position="21"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="436" mass="48733" checksum="EA9940867694B755" modified="2004-07-05" version="1">MKKSFAVKILFLCMSFLILAGCTNKGKKQLTAEIEFWSFPNFTSETGEGGGFEKSLIEAFQKEYPGVKVNFTLISFADGEAKIEAAIAEGKAPDVIYDAPGRILAWAERGLLEPLDDVLATEKPYITTGLLEISAGKDRRSYMYPMHGGPFSMAFNKEMLEDLGLIDLLPYKRLDRCWTVAEYETLLKSLKEKLPKGKTPGVFYYKTMGGDQGTRAFLVNLFGDANLLNEDYSKYIFNSSQAVKNLKWTIDAMKEGLLLDGAELTSNDAISMFAESKAAHTILYSPQLNKMYDGKRNYKGKDFTPIYMPFPNDSSAPLLEFLAGGACVFKSSDKQKIEAAKLFLKFAATDEVWAYKLVKATGGFPATSKIQIETSDDEILYNSVLQKFFGQYYNNITGFSKMREYWNKALKEASSGKDIQNVLNSFVKDADRTLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N88</accession>
    <name>Q73N88_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">purD</name>
        <name evidence="10" type="ordered locus">TDE_1267</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971874.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678770.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1267"/>
    <dbReference type="EnsemblBacteria" id="AAS11785">
        <property type="protein sequence ID" value="AAS11785"/>
        <property type="gene ID" value="TDE_1267"/>
    </dbReference>
    <dbReference type="GeneID" id="2740560"/>
    <dbReference type="KEGG" id="tde:TDE_1267"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1218"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_1_12"/>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="OrthoDB" id="932854at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="113"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="437" mass="47172" checksum="545418BEF932BDDC" modified="2004-07-05" version="1">MNILLVGSGGREHAIALKLKESPSLGKLFIAPGNGGTALLGENVPIKADNIEGLADFALSASIDLVIAGPEVPLCLGFEDLIKEKAKAQNKKIAFFGPSKACARLEASKDFSKEMMSLLSIPTARYSSFTDFQKAKKYIEGLDYPFVIKADGLAAGKGVILPDSKEEGIAELKNIMIEKQFGTSGDKVVIEERLEGEEVSILAFSDGEKIAVMPPSQDHKRLKDNDEGPNTGGMGAYAPTPICSYEEAEKYAALTILPIVKEMKKRGTPYIGVLYAGIMLTKDGKGFTPKVLEYNCRFGDPETQVLMQLFDGDLALTMSYCAEGRLGEAMPKWKKGYAATVVLASEGYPLSSSKPVELSASELEGSAEVSVIHAGTALKDSKIFASGGRVLCISSNDKSLQKAMDNIYEKIKTIHFPGVQYRKDIAKRGLEHLNQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ND2</accession>
    <name>Q73ND2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">troD</name>
        <name evidence="8" type="ordered locus">TDE_1223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971830.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678716.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1223"/>
    <dbReference type="EnsemblBacteria" id="AAS11741">
        <property type="protein sequence ID" value="AAS11741"/>
        <property type="gene ID" value="TDE_1223"/>
    </dbReference>
    <dbReference type="GeneID" id="2740117"/>
    <dbReference type="KEGG" id="tde:TDE_1223"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1178"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_4_1_12"/>
    <dbReference type="OMA" id="ALMGDGI"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="366" mass="39760" checksum="0BC9C29B558699BB" modified="2004-07-05" version="1">MNMEIILIAIIVSASCALCGVFLVLRRMSLMGDAISHSIIIGIVLGFFISKTLSSSIPLIGAVIAGMASVIFTEVLQKTKLIKSDAAIGLVFPFLFSLGVILVSLYAGNVHLDTDSVLLGELAFAPFDRISFFSVSFPKSLVQMICILLFDFVFIVVFFKELKLTTFDPNLAKSLGFSPSIMHYGLMFAVSLTCVGAFDSVGAVLVTALMIAPAAAALLLTNSLFYMIIISIVIASASSICGFYLAVKIDGSISGSMAAMTGVFFLLAYLFSPKDGLVKRRAEQKNLKIDFAVKMLIVHLLHHQGKENMISECREEHLCEHINWTEKKAHAVVFAAKRLGYIKKENGLLLLSPLGRQEAEKSITNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ND3</accession>
    <name>Q73ND3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971829.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678714.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1222"/>
    <dbReference type="EnsemblBacteria" id="AAS11740">
        <property type="protein sequence ID" value="AAS11740"/>
        <property type="gene ID" value="TDE_1222"/>
    </dbReference>
    <dbReference type="GeneID" id="2740116"/>
    <dbReference type="KEGG" id="tde:TDE_1222"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1177"/>
    <dbReference type="eggNOG" id="COG1321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_0_2_12"/>
    <dbReference type="OMA" id="IIIRVEN"/>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="222" mass="25412" checksum="F6CEF29B4BF7308C" modified="2004-07-05" version="1">MKISQITTENYLKAIVKFLSESDKEKITTGELAKLLHVTPGTATSMAKKLEKEKYIEYQNRIGCRLTEKGKKYGLNILRRHRLIETFLFQTLKMDGKNIHNEAENLEHAASDLLIDKIDKYLGHPKRDPHGAMIPRKNQKEYTCTDSSLDKVKCGIEYSISRLTGTDAQFEYYKTINLKLNSKIILQNKNEESGLAEIIIDGNKISCSTMILKNIFVEKIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NF9</accession>
    <name>Q73NF9_TREDE</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ordered locus">TDE_1194</name>
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    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS11712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="EnsemblBacteria" id="AAS11712">
        <property type="protein sequence ID" value="AAS11712"/>
        <property type="gene ID" value="TDE_1194"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG5373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_332014_0_0_12"/>
    <dbReference type="OMA" id="LDGNWVT"/>
    <dbReference type="OrthoDB" id="2109419at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019286">
        <property type="entry name" value="DUF2339_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38434">
        <property type="entry name" value="PTHR38434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10101">
        <property type="entry name" value="DUF2339"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
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    </dbReference>
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            <end position="24"/>
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        <location>
            <begin position="821"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS11712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="856" mass="97523" checksum="7A9181031046A92C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NG1</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ordered locus">TDE_1192</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
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                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
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            <dbReference type="PubMed" id="15064399"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11710">
        <property type="protein sequence ID" value="AAS11710"/>
        <property type="gene ID" value="TDE_1192"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1192"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="53" mass="6252" checksum="5A22FF7CA7C8DCFB" modified="2004-07-05" version="1">MKARLLKFGSLKAAKRVKKNKKTFKKLLTKSEKILYTPFCSLHNFYKFLADDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NL5</accession>
    <name>Q73NL5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS11626"/>
        <property type="gene ID" value="TDE_1137"/>
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    <dbReference type="KEGG" id="tde:TDE_1137"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="227" mass="26363" checksum="76B64C61634B4284" modified="2004-07-05" version="1">MPAIGWVVILIIGIIVIPPLFILLLKKGGKMSILGQTIEVYEGGKIQKIDSIGLMYLMKDNCEKIELLRKERIEDILPDLSYLLSDISVLACCMYRAESILNKRLYKNGFEELTVDSVNSYIKQLAEELFIRLNKEILISKSCTTRPLNELKKEKIYFIAQDFTKRVTRIYLKEVKSKADMYLNYKPLFEKIGDKIRADFCRDKMEKKLKQAENLRAVLEKLTRNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NM1</accession>
    <name>Q73NM1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971739.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670713.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1131"/>
    <dbReference type="EnsemblBacteria" id="AAS11620">
        <property type="protein sequence ID" value="AAS11620"/>
        <property type="gene ID" value="TDE_1131"/>
    </dbReference>
    <dbReference type="GeneID" id="2739990"/>
    <dbReference type="KEGG" id="tde:TDE_1131"/>
    <dbReference type="HOGENOM" id="CLU_2453717_0_0_12"/>
    <dbReference type="OrthoDB" id="2166829at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="89" mass="10225" checksum="C73CC7637708F729" modified="2004-07-05" version="1">MINSSAEIQLHCLSAEFCTYEYKTSHYYMCVLFGTHLKKLFSQIDSLSALADTMKNFLTEQSRKALIFAAKSFYRSNLWGQILLGVFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NN5</accession>
    <name>Q73NN5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971725.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956878.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1117"/>
    <dbReference type="EnsemblBacteria" id="AAS11606">
        <property type="protein sequence ID" value="AAS11606"/>
        <property type="gene ID" value="TDE_1117"/>
    </dbReference>
    <dbReference type="GeneID" id="2739533"/>
    <dbReference type="KEGG" id="tde:TDE_1117"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1077"/>
    <dbReference type="HOGENOM" id="CLU_3141869_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="49" mass="5628" checksum="1A64F6D12AB71DB3" modified="2004-07-05" version="1">MSIIINKFSQKRCINFQNINYYNLVRPAAVNIKKLGCEYLSFGKAGWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NS6</accession>
    <name>Q73NS6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971684.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677558.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1076"/>
    <dbReference type="TCDB" id="3.A.1.5.47">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11565">
        <property type="protein sequence ID" value="AAS11565"/>
        <property type="gene ID" value="TDE_1076"/>
    </dbReference>
    <dbReference type="GeneID" id="2739088"/>
    <dbReference type="KEGG" id="tde:TDE_1076"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1036"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_12"/>
    <dbReference type="OMA" id="GRYPHMF"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="BRENDA" id="7.4.2.9">
        <property type="organism ID" value="6426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="15"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="62"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="346" mass="39139" checksum="1D14C2E337F03343" modified="2004-07-05" version="1">MSDNEKKIDPNDHVLELINIKKYFEPHQGFVQSLSKGTAKKIKAVDDVTLRLRRGEIFGLIGESGSGKTTIGKIAMKLHTPTEGTILYNGEDVTNSDKEKTAFYRRRVQMIFQDPYASMNPRFKIRDVMEEPLLIHKIKGTRAENDEKIIKAISEVKLNPPEEFMTRYPHMLSGGQRQRIATARTLILNPEVIVADEPVSMIDLSTRAEILHMMREVQRKLGLTYLYITHDLSTARYFTDRIAVMYLGRIVEMGDADDVIDNPMHPYTQALIEAVPEPKPGMLEVIKKLPISGEIPSPANVPSGCRFHTRCPYADESCSSMEEPSLMDIGKGHFHACRKAEEIKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NV7</accession>
    <name>Q73NV7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971653.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682353.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1045"/>
    <dbReference type="EnsemblBacteria" id="AAS11534">
        <property type="protein sequence ID" value="AAS11534"/>
        <property type="gene ID" value="TDE_1045"/>
    </dbReference>
    <dbReference type="GeneID" id="2741319"/>
    <dbReference type="KEGG" id="tde:TDE_1045"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1005"/>
    <dbReference type="eggNOG" id="COG2832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113299_3_0_12"/>
    <dbReference type="OMA" id="AGACYMR"/>
    <dbReference type="OrthoDB" id="2047758at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007401">
        <property type="entry name" value="DUF454"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35813">
        <property type="entry name" value="PTHR35813"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04304">
        <property type="entry name" value="DUF454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016789">
        <property type="entry name" value="DUF454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="139" mass="15899" checksum="D6E4ED3F3DFA5C02" modified="2004-07-05" version="1">MKIINIFWIVLGFICLGLGVIGIIMPILPTTPFFLVTVVCFARGSERLKQWFMSTSFHKKYIQSFYEKKGMTLKNKLIILSFASIMLVAAFYFSAKPYARILIACVFLAKYYVFIFKIKTLPDDEKSAIKADAGCVEQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P09</accession>
    <name>RL28_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmB</name>
        <name type="ordered locus">TDE_0991</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971600.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670427.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73P09"/>
    <dbReference type="SMR" id="Q73P09"/>
    <dbReference type="STRING" id="243275.TDE_0991"/>
    <dbReference type="PRIDE" id="Q73P09"/>
    <dbReference type="EnsemblBacteria" id="AAS11481">
        <property type="protein sequence ID" value="AAS11481"/>
        <property type="gene ID" value="TDE_0991"/>
    </dbReference>
    <dbReference type="GeneID" id="2739068"/>
    <dbReference type="KEGG" id="tde:TDE_0991"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.953"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_7_0_12"/>
    <dbReference type="OMA" id="RINVCTS"/>
    <dbReference type="OrthoDB" id="2062238at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000178579" description="50S ribosomal protein L28">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <sequence length="63" mass="6985" checksum="0772E0CFA00A6D61" modified="2004-07-05" version="1">MSRVCEICGKGSLSGNSVSKSKIHTKRVWKPNLVNVKTEIGGRTLTIKMCSRCLKSDYVTKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P11</accession>
    <name>Q73P11_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971598.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0989"/>
    <dbReference type="EnsemblBacteria" id="AAS11479">
        <property type="protein sequence ID" value="AAS11479"/>
        <property type="gene ID" value="TDE_0989"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0989"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.951"/>
    <dbReference type="eggNOG" id="ENOG5032Q4X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_1_1_12"/>
    <dbReference type="OMA" id="PITIPNR"/>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="78" mass="9067" checksum="0B048D145BDACCA2" modified="2004-07-05" version="1">MLEKIKSLDNNMRFSELAKVLKTYGYIMTSPRSGSSHYTFRKKGCNPITIPNRAPIKSIYVRMVKEVVEAEENNQKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P15</accession>
    <name>Q73P15_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligopeptide/dipeptide ABC transporter, periplasmic peptide-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971594.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671910.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0985"/>
    <dbReference type="EnsemblBacteria" id="AAS11475">
        <property type="protein sequence ID" value="AAS11475"/>
        <property type="gene ID" value="TDE_0985"/>
    </dbReference>
    <dbReference type="GeneID" id="2739062"/>
    <dbReference type="KEGG" id="tde:TDE_0985"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.947"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026689_0_0_12"/>
    <dbReference type="OMA" id="RNYMGAK"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="133"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="645" mass="75247" checksum="E8B61D98572E3FA7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P45</accession>
    <name>Q73P45_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0954</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971564.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956847.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0954"/>
    <dbReference type="EnsemblBacteria" id="AAS11445">
        <property type="protein sequence ID" value="AAS11445"/>
        <property type="gene ID" value="TDE_0954"/>
    </dbReference>
    <dbReference type="GeneID" id="2740762"/>
    <dbReference type="KEGG" id="tde:TDE_0954"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.918"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_3_12"/>
    <dbReference type="OMA" id="IARIWVE"/>
    <dbReference type="OrthoDB" id="1215743at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="278" mass="29646" checksum="24E5DB33D3F3861B" modified="2004-07-05" version="1">MIEAALVILKMSAPLLFLVLGALLTEYAGSLAVFMEGAVILSAFFCALITIISGNPFLGFIVSVLLTSLILYLLALFTVKTRANSFLTGLSLNLFAAGFVPWASELFLKKGGVLSFEDFEASSHLVPVNNLNPFFAGLILAIVIFVLLKYSSKGISLKYSGEAPDVLIAHGINPNNYKIFSWTIAGFFAACSGSTLVFRLAAYTPNISAGRGWTALAAIFLGNKNPLLCTLAVLLFSSAEYAVNIMQGAVKIPSGILLSVPYIVALIFFIAAPSVRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P48</accession>
    <name>Q73P48_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_0951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971561.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0951"/>
    <dbReference type="EnsemblBacteria" id="AAS11442">
        <property type="protein sequence ID" value="AAS11442"/>
        <property type="gene ID" value="TDE_0951"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0951"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.915"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_0_1_12"/>
    <dbReference type="OMA" id="FRVVGNW"/>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285877" evidence="7">
        <location>
            <begin position="25"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Bmp" evidence="8">
        <location>
            <begin position="36"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="348" mass="37935" checksum="1A00453E0DDCF3B2" modified="2004-07-05" version="1">MSAMRKIINFILFASFLLAVFSCAKTENLQKEKEIAIAVFVPGVRAESPVYDMLSSGVEEAVASAIGNGKKVSLKILEAGTNQAEWGTKLTSLAVDGKYDLIVSSNPAMPGIAAPISKQFPNQKFLLLDAYSEGNPMITTFRYNQREQAYIAGHISALVSLSKMEFANPEKKIGLIAGQEYPAMMNIILPAFIEGAKAVDPEFTVDFKIVGNWYDAAKGAELARAMYKNGADVIMPISGGANQGVLAAAKELGFYVSWFDDNGYAKAKGYVISSSEMKQKKLAYEQILNFIDGKLQEGTASTLGIKEGYVNFVSDDEIYIQTVPEEIRKQQDEILKKIVDGSLDLSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P81</accession>
    <name>Q73P81_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971528.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956838.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11409">
        <property type="protein sequence ID" value="AAS11409"/>
        <property type="gene ID" value="TDE_0918"/>
    </dbReference>
    <dbReference type="GeneID" id="2740383"/>
    <dbReference type="KEGG" id="tde:TDE_0918"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.887"/>
    <dbReference type="HOGENOM" id="CLU_299334_0_0_12"/>
    <dbReference type="OrthoDB" id="38271at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1208" mass="142708" checksum="6136BDF4A7FB842C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P92</accession>
    <name>Q73P92_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971517.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682200.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0907"/>
    <dbReference type="EnsemblBacteria" id="AAS11398">
        <property type="protein sequence ID" value="AAS11398"/>
        <property type="gene ID" value="TDE_0907"/>
    </dbReference>
    <dbReference type="GeneID" id="2739947"/>
    <dbReference type="KEGG" id="tde:TDE_0907"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.878"/>
    <dbReference type="eggNOG" id="ENOG502ZH5B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093450_6_0_12"/>
    <dbReference type="OrthoDB" id="1414983at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011733">
        <property type="entry name" value="CHP02185_IM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09605">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02185">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="198" mass="21521" checksum="5B04AE915DEDCC2A" modified="2004-07-05" version="1">METKTNHWKISHFVLIGLMAAIYAAVIYGVGMLTAVTIPVMHVFAPGMTGFLMGPIVLFVVKTVRRFGVLTLLAGLGVALFTLTGMGSINCLIFVVIAGLIADVIIAKTGFKTLSVGIGHGLTQAAYFTGGVFPFLFFLERELAKWQEMGMSREEILEYVKYFTGTFAVIGIVSAIVFGIAGVYIGKLILKRHFKDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PB3</accession>
    <name>Q73PB3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971496.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682162.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0886"/>
    <dbReference type="EnsemblBacteria" id="AAS11377">
        <property type="protein sequence ID" value="AAS11377"/>
        <property type="gene ID" value="TDE_0886"/>
    </dbReference>
    <dbReference type="GeneID" id="2739760"/>
    <dbReference type="KEGG" id="tde:TDE_0886"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.856"/>
    <dbReference type="eggNOG" id="ENOG5031CIN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_818712_0_0_12"/>
    <dbReference type="OMA" id="HWIILPF"/>
    <dbReference type="OrthoDB" id="790092at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="317" mass="35231" checksum="313547D57DF50CB5" modified="2004-07-05" version="1">MIYTDGTKVFFTASRRAASGSMSLKNGDIVNAKILSLKTDGAARIFFNGNIFEGNVSGSLKEGDSLKMRVVIDSDKVLLIPEKGDDASSSKDIFSKLGLPQNELTSSILAFFTAIESRLDEKSINRIFNFLHKKTAGKASDRASLKEKEKSAFAASLIESKGIELSDELFSQIYEAIFGGGKEKNDDEVLEMINHLKGDGLHWIILPFDREFDSSKASGSLALLLDISLKELKSLVLRCNFKSSGEDESWIFSLKDKEFTFMREDTELSQKEKTNLEKLFTSCLTETGFFDSDTASVFVRYGEPPKYEPPLSVDLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PC2</accession>
    <name>Q73PC2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrolase_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971487.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682158.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0877"/>
    <dbReference type="EnsemblBacteria" id="AAS11368">
        <property type="protein sequence ID" value="AAS11368"/>
        <property type="gene ID" value="TDE_0877"/>
    </dbReference>
    <dbReference type="GeneID" id="2740924"/>
    <dbReference type="KEGG" id="tde:TDE_0877"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.847"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033707_1_0_12"/>
    <dbReference type="OMA" id="HVMARLG"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285880" description="Hydrolase_4 domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="67"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="316" mass="34953" checksum="C9FC0A382C092551" modified="2004-07-05" version="1">MFKFKNFRFTTAVLFLFSALSLYGADLEIKAEGTVLAGTLLFPKAEKAVSVCIIVPGSGPIDRDGNSGFNLRADTYKLLAEGLAENGIASFRYDKRGVGKSLPAQFKEEDIRFETNVQDLKAIISHLKSLKKFKKIFLIGHSEGSLVSILCAKTEKVDGFISIAGVGKNSADLILEQIEKNPANPKALINSSKQIIEKLKGGKMEENVPLVLNSLFRKSVQPYLISWFKYEPKKEIAQLKIPVLVIQGGNDIQVGVEDSKLLSSAKEGIELKIIEKMTHTLKEINSPQEQMKTYIDPSYPISKDLVLAITEFVNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PH6</accession>
    <name>Q73PH6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">(3R)-hydroxymyristoyl-(Acyl-carrier-protein) dehydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971433.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670104.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0823"/>
    <dbReference type="EnsemblBacteria" id="AAS11314">
        <property type="protein sequence ID" value="AAS11314"/>
        <property type="gene ID" value="TDE_0823"/>
    </dbReference>
    <dbReference type="GeneID" id="2739507"/>
    <dbReference type="KEGG" id="tde:TDE_0823"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.793"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078912_1_2_12"/>
    <dbReference type="OMA" id="FPGRPLM"/>
    <dbReference type="OrthoDB" id="1763197at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="143" mass="15901" checksum="E353A0B72400AEAD" modified="2004-07-05" version="1">MSVTKDIESLIPHRKPFLFVDEIISADENGSVSEHVFTQDEFFFKGHFPEYPVVPGVILVETMAQAGGAALSFQKIFEEGSLFFLATVDKVKFRSQVKPGDKVRMEVTNLRVSPRMIKQAGKAYVGDTLAAEAEWMCLVGKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PI9</accession>
    <name>Q73PI9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971420.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672148.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0810"/>
    <dbReference type="EnsemblBacteria" id="AAS11301">
        <property type="protein sequence ID" value="AAS11301"/>
        <property type="gene ID" value="TDE_0810"/>
    </dbReference>
    <dbReference type="GeneID" id="44155127"/>
    <dbReference type="KEGG" id="tde:TDE_0810"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.782"/>
    <dbReference type="HOGENOM" id="CLU_209289_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="55" mass="6319" checksum="F8DA7C4CA30E2811" modified="2004-07-05" version="1">MTRLVDISKSISCNMNEINQKSELIAGKIDRAMNMTEENKQAVSKIFSYLERLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PP6</accession>
    <name>Q73PP6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Magnesium chelatase, subunit D/I family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971362.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682012.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0751"/>
    <dbReference type="EnsemblBacteria" id="AAS11243">
        <property type="protein sequence ID" value="AAS11243"/>
        <property type="gene ID" value="TDE_0751"/>
    </dbReference>
    <dbReference type="GeneID" id="2739870"/>
    <dbReference type="KEGG" id="tde:TDE_0751"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.726"/>
    <dbReference type="eggNOG" id="COG1239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016684_0_2_12"/>
    <dbReference type="OMA" id="RISAVCG"/>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="30"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="309" mass="34680" checksum="751C389C644F1103" modified="2004-07-05" version="1">MTEKQIFPFVQIEGQEDIKLAIILNLICPAISGVLIRGEKGTGKSTIVRGIGELMQRQGENLKVIELPINATEDRVAGSIDIERVLKTGEKVLQKGILAEADGNILYADEINLLEDYIVDLLLDAAAMGVNTIERDGISYSHSSKFILIGTMNPEEGELRPQLLDRFGLLVDVKSEKDGHLRKEIIKKRLAFENDPVEFINASHKEEKKLISKIKKAQKRLPLIKTTDEILDLVVSLSIGLNVDGHRGDLTLVRAAKAYAAFQERDEVTKDDIIRLAQMVYSHRLRKKPFEEINPLNQADIENILNERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PR0</accession>
    <name>Q73PR0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971348.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681991.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0737"/>
    <dbReference type="EnsemblBacteria" id="AAS11229">
        <property type="protein sequence ID" value="AAS11229"/>
        <property type="gene ID" value="TDE_0737"/>
    </dbReference>
    <dbReference type="GeneID" id="2740291"/>
    <dbReference type="KEGG" id="tde:TDE_0737"/>
    <dbReference type="eggNOG" id="COG4115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169492_2_2_12"/>
    <dbReference type="OMA" id="FEGNTWT"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="88" mass="10497" checksum="3059037055F61DE2" modified="2004-07-05" version="1">MVKVWSDIAWKDYCRLFDKHQQKLIKSTHDLIKDIERNGIDKGKGQPEPLKHELSGYWSRRIDAANRLVYKVEDNKLYIVQCGTHYHQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q15</accession>
    <name>DNAJ_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaJ</name>
        <name type="ordered locus">TDE_0629</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaJ family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAS11124" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11124.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971243.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73Q15"/>
    <dbReference type="SMR" id="Q73Q15"/>
    <dbReference type="STRING" id="243275.TDE_0629"/>
    <dbReference type="EnsemblBacteria" id="AAS11124">
        <property type="protein sequence ID" value="AAS11124"/>
        <property type="gene ID" value="TDE_0629"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0629"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.607"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_12"/>
    <dbReference type="OMA" id="DLHCTVT"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000070923" description="Chaperone protein DnaJ">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="160"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="177"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="199"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif">
        <location>
            <begin position="213"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="1">
        <location>
            <begin position="147"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="379" mass="41084" checksum="2A1A816D0CE7965E" modified="2005-04-26" version="2">MPASKRDYYEVLGVDKKASNDDIKKAYRKLAIKYHPDKNQGDKAAEEKFKEATEAYEILIDEKKRSMYDQFGHAGVDGMSGGGGYDPSAFQGFEDIFGGSFSDIFENLFGGGFSSRSSGFGGRHAGPVRGSNLRYDLQISFVDAVYGKKAELSYTRNEKCSECHGTGSESGSSKRMCPDCKGTGQVRQSTGFFSISRPCPTCGGEGSIIEKPCKKCGGNGLERKKQRIIVTIPAGVENGKRITIPSQGNAGQAGGDYGDLFVFIFVQAHPYFERNGIDLYCAVPISMTQAALGGEINIKSLDEKTLRLKIPAGTQNGKLLRIRGEGVPTGIGRKGDLYIQIQVQIPSKLSSNSKKLLQEISAIEGENENPNLIPLKDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q29</accession>
    <name>Q73Q29_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin biosynthesis protein CbiG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbiG</name>
        <name evidence="3" type="ordered locus">TDE_0615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971229.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681802.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0615"/>
    <dbReference type="EnsemblBacteria" id="AAS11110">
        <property type="protein sequence ID" value="AAS11110"/>
        <property type="gene ID" value="TDE_0615"/>
    </dbReference>
    <dbReference type="GeneID" id="2740460"/>
    <dbReference type="KEGG" id="tde:TDE_0615"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.594"/>
    <dbReference type="eggNOG" id="COG2073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028397_0_0_12"/>
    <dbReference type="OMA" id="GIGCNRG"/>
    <dbReference type="OrthoDB" id="1617773at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021744">
        <property type="entry name" value="CbiG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038029">
        <property type="entry name" value="GbiG_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11760">
        <property type="entry name" value="CbiG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159672">
        <property type="entry name" value="SSF159672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiG_N" evidence="2">
        <location>
            <begin position="45"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_C" evidence="1">
        <location>
            <begin position="228"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="347" mass="38081" checksum="562310BE4027F4BE" modified="2004-07-05" version="1">MKKIAVYSFTEKGNLLGEKLSGLDSQIEHFYNAKTAGGIRSLIPDDFKNRDALIFISSTGIAVRMIKDYIKDKTQDPAVLVIDDLGRFVISLLSGHLGGANALTEKIAKLLGAVSVITTASDGRNIEAVDLFAQKNNYAILSMEDAKIITSLMVDGKSIGFCSEDKTPPINYPHLFILQEKDFNSHLKALTEEKKLEGLIIVSNKKRETVSALSRFLPIVHLVPKNLNLGIGLKKGVDKETVAEAVKKALDSINKDLIAVKEIASIDLKQNEKGLLEFAKELKISPVFFSKSRIEKIEDNFEKSEFVKKTVGVYNVSAPSAFLLGGKIILDKFKHEGVTVSVAESMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q37</accession>
    <name>Q73Q37_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971221.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681790.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0607"/>
    <dbReference type="EnsemblBacteria" id="AAS11102">
        <property type="protein sequence ID" value="AAS11102"/>
        <property type="gene ID" value="TDE_0607"/>
    </dbReference>
    <dbReference type="GeneID" id="2739163"/>
    <dbReference type="KEGG" id="tde:TDE_0607"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.587"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_12"/>
    <dbReference type="OMA" id="VQCEYFA"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="251" mass="27514" checksum="D898B373CF986606" modified="2004-07-05" version="1">MGKTFVFVNQKGGVGKTTSVINLGAYIALAGKKTLLIDFDPQGNMSSGVGIQKKRPTIYDALAQKTSIKNTIYPTTVKNLSAIPASIDLSGATVELVDEADREFYLKNIIESVKNEYDYILIDCPPSLGILTLNGLTAADQVYIPLQCEYFALEGLTLLLQTVQRVQQNLNPALEIGGIFFTMFDSRTNLAQEVVQQVSSYFKDKVFSTIIPRNVRLSEAPSHGVPICNYDAKCTGARSYEKLADEVLNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q63</accession>
    <name>Q73Q63_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transglutaminase-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0581</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971195.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681748.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0581"/>
    <dbReference type="EnsemblBacteria" id="AAS11076">
        <property type="protein sequence ID" value="AAS11076"/>
        <property type="gene ID" value="TDE_0581"/>
    </dbReference>
    <dbReference type="GeneID" id="2741017"/>
    <dbReference type="KEGG" id="tde:TDE_0581"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.562"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_264084_0_0_12"/>
    <dbReference type="OMA" id="IWERDMI"/>
    <dbReference type="OrthoDB" id="119432at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="654"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="434"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="706"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="808"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1238" mass="143984" checksum="0D0D71D52F9C41C9" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q84</accession>
    <name>Q73Q84_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971173.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0559"/>
    <dbReference type="EnsemblBacteria" id="AAS11054">
        <property type="protein sequence ID" value="AAS11054"/>
        <property type="gene ID" value="TDE_0559"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0559"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.544"/>
    <dbReference type="eggNOG" id="ENOG5031CC0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1400565_0_0_12"/>
    <dbReference type="OMA" id="GENDAFC"/>
    <dbReference type="OrthoDB" id="1444079at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="195" mass="23013" checksum="1BDBCA93FD7D70DD" modified="2004-07-05" version="1">MDNSNCNIQEWVNLNSYTDSKGWKGYCRRNKPFTIFRANKIVRCFMHFFRKYTNNIIIISNIFKVKEYNLNNSNINNYIKYIEKYLIDFGYIETISASIYDNDNCLSLGFKKFLTTDYDIISMFSLLMMMDEGIDGHCFFVFDELGFIAYPHDDTGFGFIRIKNTKVHYEDMFLKSVSQFSDFTSVVKGNILIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q95</accession>
    <name>Q73Q95_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971162.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11043">
        <property type="protein sequence ID" value="AAS11043"/>
        <property type="gene ID" value="TDE_0548"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0548"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.533"/>
    <dbReference type="HOGENOM" id="CLU_3349892_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="37" mass="4351" checksum="BA49D945A517B03A" modified="2004-07-05" version="1">MGRLIFILLLSVSGLIFLAVIFGMYIYMKRTYRAENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QF3</accession>
    <name>Q73QF3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971104.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681597.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0490"/>
    <dbReference type="EnsemblBacteria" id="AAS10985">
        <property type="protein sequence ID" value="AAS10985"/>
        <property type="gene ID" value="TDE_0490"/>
    </dbReference>
    <dbReference type="GeneID" id="2741395"/>
    <dbReference type="KEGG" id="tde:TDE_0490"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.475"/>
    <dbReference type="eggNOG" id="ENOG5031CKZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1546878_0_0_12"/>
    <dbReference type="OrthoDB" id="1821719at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005367114" evidence="1">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="173" mass="19578" checksum="9F85B057BECCFE3C" modified="2004-07-05" version="1">MNKGIEKKARVITIALFLLGGSVFADSHKPNSKEGKHGHGKGFTYNKRSADSKADIGTAGYQLMGDWVFRGTDKAEKVEFDRDGTMEIKWHQGFDSETEWEGFWTATDTEITFTVKTKETETWINGAKKEVRENINATWKIQYSITDDTLTLTGSDLPKELANLQLSRTGRWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QL1</accession>
    <name>Q73QL1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein, truncation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971046.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0432"/>
    <dbReference type="EnsemblBacteria" id="AAS10927">
        <property type="protein sequence ID" value="AAS10927"/>
        <property type="gene ID" value="TDE_0432"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0432"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.419"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1677082_0_0_12"/>
    <dbReference type="OMA" id="YSDAYYL"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="99"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="157" mass="18262" checksum="7568665E4FB0B64F" modified="2004-07-05" version="1">MRGSFYIELKRYDDAINSANEAISLDPNYMQAYYGLILAYMSANKHNEAFEAINKTIKLKPPYIDMLYGFRASLFSLQGRYKEAIEDCNTSIKINFHNAIVYNIRGTAYLALKEYKKAIEDFDMAIKFALENQNTEKQDAIEYKQKAYEALAEMERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QM7</accession>
    <name>Q73QM7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacteriocin-type signal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971030.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956736.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0416"/>
    <dbReference type="EnsemblBacteria" id="AAS10911">
        <property type="protein sequence ID" value="AAS10911"/>
        <property type="gene ID" value="TDE_0416"/>
    </dbReference>
    <dbReference type="GeneID" id="2739057"/>
    <dbReference type="KEGG" id="tde:TDE_0416"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.403"/>
    <dbReference type="HOGENOM" id="CLU_1879957_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="167" mass="18992" checksum="8CC256A4011A2F7E" modified="2004-07-05" version="1">MKKFIKLTDEELLKINGGGEINDAIDDEVVLSRKRRINLEKSQDTVREAAIYRPYAKGNFDYEGAAEGVTWCNQSSYDVMEATGVHMKPFYGKPDGYKGKEGQRGAGYWVNANTACKNVENYIDKYAKEWVNAKIKEVGLTNIEAEFDYIGPNSVKNYNEAYTKKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QR1</accession>
    <name>Q73QR1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970996.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681407.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0382"/>
    <dbReference type="EnsemblBacteria" id="AAS10877">
        <property type="protein sequence ID" value="AAS10877"/>
        <property type="gene ID" value="TDE_0382"/>
    </dbReference>
    <dbReference type="GeneID" id="2739475"/>
    <dbReference type="KEGG" id="tde:TDE_0382"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.371"/>
    <dbReference type="HOGENOM" id="CLU_2756618_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="70" mass="8309" checksum="458D57E05B883681" modified="2004-07-05" version="1">MIVKIKIQKFLSFAIFIFLSSIVTASLFAGEKVYLEIKIDGEEIGKWVELEYHKDGKTLKKDTCYWYERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QW0</accession>
    <name>Q73QW0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0333</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970947.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681298.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0333"/>
    <dbReference type="EnsemblBacteria" id="AAS10828">
        <property type="protein sequence ID" value="AAS10828"/>
        <property type="gene ID" value="TDE_0333"/>
    </dbReference>
    <dbReference type="GeneID" id="2741549"/>
    <dbReference type="KEGG" id="tde:TDE_0333"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.322"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_0_0_12"/>
    <dbReference type="OMA" id="EFWILLK"/>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="451" mass="49553" checksum="55F21A5E7807798E" modified="2004-07-05" version="1">MTDKREHLISGNMFKLMLELSIPGIIGMFVISLYSFVDAIFVGRYVSSVALGAVSLAYTFTLINNGIAVLVGIGSASVLSRAVGRSDQETVDSIMGNVLLLTLLFSLGTMTIGLIFAPQLLILIGAEGEMLRLGVSYLRIVYIGSVFVNFGQAANMVMRGEGRMGLAMLLMGISAVLNIILDAVFVIVLKKGLEGTAIATVISQVVLAICNFCYFAFFSKNVKFKHFKLQKSIVKETLSIGFSAMLMQVFALLQQAVMYSTLKRYGGEDQVILMGAFFRYMMLSFIPLWGISQGYQPFAGTNFGAQKFERVKKGTFLFYGFGLFLSLIFWLVFLIIPEQVLGLFLKNKELISLGRTNAMLAMSLFPLSAIMIINLTLFQALGKAKYAGILVIARQFLLYIPAVLILPVFFGTRGVWISTPIIDTLVTVLSAFIVIKLFKKDLSPKDKPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R43</accession>
    <name>Q73R43_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoredoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970864.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681169.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0249"/>
    <dbReference type="EnsemblBacteria" id="AAS10745">
        <property type="protein sequence ID" value="AAS10745"/>
        <property type="gene ID" value="TDE_0249"/>
    </dbReference>
    <dbReference type="GeneID" id="2739674"/>
    <dbReference type="KEGG" id="tde:TDE_0249"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.244"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_5_5_12"/>
    <dbReference type="OMA" id="YVAEFPL"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="12"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="187" mass="20415" checksum="A462C2F700C3AACE" modified="2004-07-05" version="1">MRKKLDITDGIFPMPVLMVATYNDDGSINVMNAAWGTMQERSIIALNLTETHKTVKNIKARGAFTVSIADAAHVLEADYFGVASGNKVPNKLEKTGLTASKAETVDAPVINEFPICLECEFIEYQNDKYGCGVIGKVVNVTADESVMPNGKLDMSLVNAIAFDPYTHGYYKVSERVGEAFKDGLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R70</accession>
    <name>Q73R70_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970837.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681124.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0221"/>
    <dbReference type="EnsemblBacteria" id="AAS10718">
        <property type="protein sequence ID" value="AAS10718"/>
        <property type="gene ID" value="TDE_0221"/>
    </dbReference>
    <dbReference type="GeneID" id="2741127"/>
    <dbReference type="KEGG" id="tde:TDE_0221"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.214"/>
    <dbReference type="eggNOG" id="ENOG502ZP34">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1277147_0_0_12"/>
    <dbReference type="OrthoDB" id="1625424at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="216" mass="25348" checksum="EB25A324462AD1AA" modified="2004-07-05" version="1">MQQTFSDLKTKIDNLLKEDTEEKIVLILQDIMYTLLSDYVFKIQGNKGFVTIDPIEIEAYFFKEVCFEDDCVHRNEKQKNNFGNLYVHKTKNNHLKGGTRKGMDLCLSDSESYTLAFLIRSAYVNSMKNRICGPSLLTDGVFEELGFDYKKYYNKLESQPVLFKEKKPEAEFYLSKRINVNSKMQSSLLRMVRIEDNYFTGLKEINKLKSRPFFID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2021-09-29" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RG3</accession>
    <name>DGCA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diguanylate cyclase A</fullName>
            <shortName evidence="5">DGC</shortName>
            <ecNumber evidence="4">2.7.7.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dgcA</name>
        <name evidence="6" type="ordered locus">TDE_0125</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2021" name="Pathog. Dis." volume="79" first="0" last="0">
            <title>The Treponema denticola DgcA protein (TDE0125) is a functional diguanylate cyclase.</title>
            <authorList>
                <person name="Patel D.T."/>
                <person name="O'Bier N.S."/>
                <person name="Schuler E.J.A."/>
                <person name="Marconi R.T."/>
            </authorList>
            <dbReference type="PubMed" id="33452878"/>
            <dbReference type="DOI" id="10.1093/femspd/ftab004"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>MUTAGENESIS OF ARG-273; ASP-276 AND 282-GLY-GLY-283</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GTP to cyclic-di-GMP (c-di-GMP). Shows activity under aerobic and anaerobic reaction conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:24898"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58805"/>
            <dbReference type="EC" id="2.7.7.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Shows higher activity with Mn(2+) than Mg(2+).</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="4">Allosterically regulated by a feedback inhibition loop.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Exists as a homodimer and as larger aggregates. Both dimers and aggregates possess DGC activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.65" evidence="4"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970742.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73RG3"/>
    <dbReference type="STRING" id="243275.TDE_0125"/>
    <dbReference type="EnsemblBacteria" id="AAS10623">
        <property type="protein sequence ID" value="AAS10623"/>
        <property type="gene ID" value="TDE_0125"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0125"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.125"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_24_12"/>
    <dbReference type="OMA" id="TTDMMTK"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000453204" description="Diguanylate cyclase A">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="233"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Forms dimers and tetramers and shows enhanced activity; when associated with A-276." evidence="4">
        <original>R</original>
        <variation>A</variation>
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Forms dimers and tetramers and shows enhanced activity; when associated with A-273." evidence="4">
        <original>D</original>
        <variation>A</variation>
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of activity. Forms exclusively large aggregates." evidence="4">
        <original>GG</original>
        <variation>AA</variation>
        <location>
            <begin position="282"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P31129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="33452878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="33452878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS10623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="371" mass="41992" checksum="EBBE02028C3310FB" modified="2004-07-05" version="1">MKTTPNEKLLKKALHSCNNKKYADKILHQEKEIFDLKQLLQISKSLNSVLEFDRLIEAILYIVMAQLKTLGAAIFTKKSFDDNLFVLNRDHYGFDIIRDAQYSINVDHPLINFLDKSDSGCTPDEISKNIKTDKIVKDLFSLSPSFFVPLKAKNRMIGFLLLGEKMESSHQFTDYEKNIIENIASLAAIAINNSQLLEMTTTDIMTHLKLKHYFFTLLMEHLYTINSSGEKKETLSILMIDIDFFKNINDTYGHAAGDIVLEEVAKIIKSCTRNADTAARYGGEEFIVMLNNTSASAAMAVAERIRKSVEEKSIMYDGKKINVTISIGVSSYNFDLESAKSIVERADKALYESKQNGRNRVTLSKNNLPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RI0</accession>
    <name>Q73RI0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-03" db="PDB data bank">
            <title>Structure Treponema Denticola Factor H Binding Protein.</title>
            <authorList>
                <person name="Miller D.P."/>
                <person name="McDowell J.V."/>
                <person name="Burgner J."/>
                <person name="Heroux A."/>
                <person name="Bell J.K."/>
                <person name="Marconi R.T."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 24-102</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2012" name="J. Biol. Chem." volume="287" first="12715" last="12722">
            <title>Structure of factor H-binding protein B (FhbB) of the periopathogen, Treponema denticola: insights into progression of periodontal disease.</title>
            <authorList>
                <person name="Miller D.P."/>
                <person name="Bell J.K."/>
                <person name="McDowell J.V."/>
                <person name="Conrad D.H."/>
                <person name="Burgner J.W."/>
                <person name="Heroux A."/>
                <person name="Marconi R.T."/>
            </authorList>
            <dbReference type="PubMed" id="22371503"/>
            <dbReference type="DOI" id="10.1074/jbc.M112.339721"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS) OF 24-102</scope>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970725.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680965.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="PDB" id="3QZ0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.77 A"/>
        <property type="chains" value="A/B=24-102"/>
    </dbReference>
    <dbReference type="PDB" id="3R15">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/B=24-102"/>
    </dbReference>
    <dbReference type="PDBsum" id="3QZ0"/>
    <dbReference type="PDBsum" id="3R15"/>
    <dbReference type="SMR" id="Q73RI0"/>
    <dbReference type="EnsemblBacteria" id="AAS10606">
        <property type="protein sequence ID" value="AAS10606"/>
        <property type="gene ID" value="TDE_0108"/>
    </dbReference>
    <dbReference type="GeneID" id="2741723"/>
    <dbReference type="KEGG" id="tde:TDE_0108"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.108"/>
    <dbReference type="eggNOG" id="ENOG5030W9M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2248873_0_0_12"/>
    <dbReference type="OrthoDB" id="2143271at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285934" evidence="1">
        <location>
            <begin position="22"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3QZ0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="3R15"/>
        </source>
    </evidence>
    <sequence length="102" mass="11395" checksum="CB8604076786E203" modified="2004-07-05" version="1">MKNKKIFTVLFLLAVSALLFTSCTFKMNTAQKAHYEKFINALENELKTRHIPAGAVIDMLAEINTEALALDYQIVDKKPGTSIAQGTKAAALRKRFIPKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RI2</accession>
    <name>Q73RI2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970723.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680960.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0106"/>
    <dbReference type="EnsemblBacteria" id="AAS10604">
        <property type="protein sequence ID" value="AAS10604"/>
        <property type="gene ID" value="TDE_0106"/>
    </dbReference>
    <dbReference type="GeneID" id="2741721"/>
    <dbReference type="KEGG" id="tde:TDE_0106"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.106"/>
    <dbReference type="eggNOG" id="ENOG5033P4X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_831384_0_0_12"/>
    <dbReference type="OMA" id="EITLIFE"/>
    <dbReference type="OrthoDB" id="544297at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004286069" evidence="1">
        <location>
            <begin position="23"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="334" mass="36936" checksum="B37E64B1672B7714" modified="2004-07-05" version="1">MKKRFFLSVLLVLSLCASCSGMIEQPGFVSIFLGDDERIILKEFEQSTNNEITLIFEGRVTGLQAYALKGNLPEEILCTVEEIEAADFLQDKAYKAKNGDLSVFKIKPGASFEIGEDFKICGKVEAQNQFLDFELPFKGANTRPAGLSFSSLKLGSASKEGFIRFSVKKSGNLFGVSLVNAGSSKEPDYVFPAFEVEAGNIIVFYWYLPLDGSMPEDGILVSADACNALEPGEKAFCFWAKLQKFQPKRTNAVLIRTSQNDGLQDAVLFRHPKDEEWGRPEIERAAVEAVEAGLWQPDGDILNAVQANITPTKMIKRISQVTINHNAADWVLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RL9</accession>
    <name>Q73RL9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_0069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970686.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680922.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0069"/>
    <dbReference type="EnsemblBacteria" id="AAS10567">
        <property type="protein sequence ID" value="AAS10567"/>
        <property type="gene ID" value="TDE_0069"/>
    </dbReference>
    <dbReference type="GeneID" id="2741684"/>
    <dbReference type="KEGG" id="tde:TDE_0069"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.70"/>
    <dbReference type="eggNOG" id="COG1509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032161_2_0_12"/>
    <dbReference type="OMA" id="HFTHPDE"/>
    <dbReference type="OrthoDB" id="557227at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004911">
        <property type="entry name" value="DUF160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="76"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR603739-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="338" mass="37800" checksum="F2B77D2C0BE30393" modified="2004-07-05" version="1">MSEKNWREFSAAETADFEQPVLISSAFQKLIEESEPEDSNALLLQVEPSACEKTVCSYETADPLGEQKYCITPYLVHQYENRVLLITTGKCLSYCRYCFRRGLTARSQSYIGDGELKAVTDYIKKMPQVTEILVSGGDPLSGGFKKLEKVLDGLRTIKEDLLIRLCTRAPIFAPELFTEELLHLLKKTKPLWLIPHINHPAELGKEQTNALNACIEAGIPIQSQTVLLKGVNDNEKTLIKLFHKLTCMGIKPGYLFQLDPAAGTSHFRVPLKEALDLWERVEPKLSGLSRPQFAVDLPEGGGKFSLSALIYSKKIIEQKEDSSFSALGADGVIHKYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RQ6</accession>
    <name>Q73RQ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding protein, HlyB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0029</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970646.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680888.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0029"/>
    <dbReference type="EnsemblBacteria" id="AAS10527">
        <property type="protein sequence ID" value="AAS10527"/>
        <property type="gene ID" value="TDE_0029"/>
    </dbReference>
    <dbReference type="GeneID" id="2741644"/>
    <dbReference type="KEGG" id="tde:TDE_0029"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.31"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OMA" id="MYEDALF"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="135"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="345"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="592" mass="67815" checksum="BA64A6A953B3F89B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-10" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>P61348</accession>
    <name>GATB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatB</name>
        <name type="ordered locus">TDE_0575</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971189.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681743.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61348"/>
    <dbReference type="SMR" id="P61348"/>
    <dbReference type="STRING" id="243275.TDE_0575"/>
    <dbReference type="PRIDE" id="P61348"/>
    <dbReference type="EnsemblBacteria" id="AAS11070">
        <property type="protein sequence ID" value="AAS11070"/>
        <property type="gene ID" value="TDE_0575"/>
    </dbReference>
    <dbReference type="GeneID" id="2741011"/>
    <dbReference type="KEGG" id="tde:TDE_0575"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.558"/>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_0_0_12"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="OrthoDB" id="497127at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000148860" description="Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B">
        <location>
            <begin position="1"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="493" mass="55535" checksum="22E96034E31B0FE4" modified="2004-05-10" version="1">MLKHGNLEYEIIIGCEIHCQLLTKTKAFCSCENRYGGIPNTRVCPCCLGLPGALPRVSKEYVEFGIKAGHALGCRINNFSKFDRKHYFYPDLVKGYQITQFYTPLCEEGEVEVNLAAQNEEPKFKKIRIERIHLEEDVGKSLHIEGSHSYIDFNRSGVPLIEIVSKPDMSTPDEAAKYMQTIREILKFIGVTDGNMEEGALRCDANVNLKIIDNGVEFRTPISEIKNMNSFKAVKDACTYEVSRQLEEYNSKDRIAFKTGFKRTMGWDEPSGQTVVQRTKTIAEDYRFMPEPDLRALELSDKFIKEVSDSVGELPEAKRLRFKKEYHLSEFDVQTLTSERELAEWFEEAAKKSSSPKKCANWILAEVLAILNETNSSLSDLKFGPEAIAELVNVIEEGKITSKQAKDVFAEMIACGKKPSAVIAEKGMEQVSDSSFIEKIVEEVFAENAEAVQDWKNGKTNVAGWLMGQVMKKSGGKANPKQAADLVNKRLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J39</accession>
    <name>Q73J39_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973335.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680795.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2737"/>
    <dbReference type="EnsemblBacteria" id="AAS13254">
        <property type="protein sequence ID" value="AAS13254"/>
        <property type="gene ID" value="TDE_2737"/>
    </dbReference>
    <dbReference type="GeneID" id="2740956"/>
    <dbReference type="KEGG" id="tde:TDE_2737"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2583"/>
    <dbReference type="HOGENOM" id="CLU_053858_0_0_12"/>
    <dbReference type="OrthoDB" id="956253at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284533" evidence="2">
        <location>
            <begin position="41"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="246" mass="26609" checksum="41C04916F928A600" modified="2004-07-05" version="1">MIKFRTKNKAFALRKTGAAALITAATLTLALLFTGCPQKAKPKAEEPTPPEYTPVAHGKLKEYIQNLPAGDTVHKIEVTGLKKEHLNDSGSGSLRSILHFGLNKKVALKLPKTVEGLTDMSNCFAECENLVSVANIPSGVRDMRGCFEGCIRLKTAPVIPYGVLEMSYCFKGCKSLTSVTLKCGCTPDWFEDTFKDCNALGVDSIKVPKAAYHQFITAEALNKMAVPGATEAEKKAKFKGLAELNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J58</accession>
    <name>Q73J58_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Magnesium transporter MgtE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mgtE</name>
        <name evidence="9" type="ordered locus">TDE_2718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a magnesium transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLC41A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973316.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680769.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2718"/>
    <dbReference type="EnsemblBacteria" id="AAS13235">
        <property type="protein sequence ID" value="AAS13235"/>
        <property type="gene ID" value="TDE_2718"/>
    </dbReference>
    <dbReference type="GeneID" id="2740937"/>
    <dbReference type="KEGG" id="tde:TDE_2718"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2567"/>
    <dbReference type="eggNOG" id="COG2239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037408_2_2_12"/>
    <dbReference type="OMA" id="TMTVAVR"/>
    <dbReference type="OrthoDB" id="1239195at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006667">
        <property type="entry name" value="SLC41_membr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036739">
        <property type="entry name" value="SLC41_membr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01769">
        <property type="entry name" value="MgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161093">
        <property type="entry name" value="SSF161093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00400">
        <property type="entry name" value="mgtE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="201"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS13235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="452" mass="50849" checksum="4F5641DC894D3A61" modified="2004-07-05" version="1">MELKENKFEQIKYLLSEKRYIEVQRTLAELNEVDIAEFLETESAQNAILMFRMLPKSMAAEVFTLLPTEQQSRFIAAATDKELVSILDEIFLDDMVDIVEEMPANVVKKILKNTGSEERMLINQFLKYPKDSAGSLMTIEYVDLKKTMTVKQALDYIRKIGLESETIYTCYVTDKNRVLEGFISLKELVLADEDKKIEQIFNREYICVNTHDDQEKVAFTFKKYGFLALPVVDNENRLIGIITVDDIMDVMEQEATEDFQRMAAMQPNEETYLETGIFKLAKHRIGWLLLLMVSETFTGTIIERYTHLVASMTILTAFIPMLMDTGGNSGSQSSTLIIRGLATGEIDLKDWKKVFFKELGIAVLVGFTLGLFSFLKSVFLGGRNPMIALTVGATLVATVTVAKITGGLLPIMAKKLKLDPAIMAGPLITTIVDTVSLIIYFKIASVLCAGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J65</accession>
    <name>Q73J65_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973309.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010692188.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2711"/>
    <dbReference type="EnsemblBacteria" id="AAS13228">
        <property type="protein sequence ID" value="AAS13228"/>
        <property type="gene ID" value="TDE_2711"/>
    </dbReference>
    <dbReference type="GeneID" id="2740930"/>
    <dbReference type="KEGG" id="tde:TDE_2711"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2560"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_966257_0_0_12"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="299" mass="34831" checksum="3A033DFF449526FA" modified="2004-07-05" version="1">MSNEQTILNPKTDWVFKLMFSKGEEGNKALISFLNAFLEDSYGKINKAEIINTELIRDRPSGETYRLDFLIRTDNGLIVDLEMQQFWKTNYHRRSQLYLMRLASRFLKTEPKEDDFLYAISLSVFGCDVPKSAELVKMSESSIIQYLYVELNELIVYTMKKRLEEYSLKDFWIRFLANYEEDKKSGMLEELCRLEEGIKMAEATLFRVTDEERRMAIELSDEKYRMYVEDERSAARREGLAEGREKGRSIGLAEGLAEGRAEGSHQKALETAKIMKNMNYPLEDIYTITGLSKEEVGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JF1</accession>
    <name>Q73JF1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973222.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680633.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2624"/>
    <dbReference type="TCDB" id="3.A.1.31.2">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13141">
        <property type="protein sequence ID" value="AAS13141"/>
        <property type="gene ID" value="TDE_2624"/>
    </dbReference>
    <dbReference type="GeneID" id="2740798"/>
    <dbReference type="KEGG" id="tde:TDE_2624"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2480"/>
    <dbReference type="eggNOG" id="ENOG502ZBND">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093450_1_0_12"/>
    <dbReference type="OMA" id="AMIHYAV"/>
    <dbReference type="OrthoDB" id="1668819at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011733">
        <property type="entry name" value="CHP02185_IM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09605">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02185">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="194" mass="21247" checksum="BF62BA4F1A7BC975" modified="2004-07-05" version="1">MKSESKLKGRDLINIGIYSAIYFVILFAVAMLGMIPIFLPLLSVFVPIIGGIPFMLFLTKVKKPGMIFIMAMIMGILMLLTGMGPWPLLICAIAGGLAELCFKSGEYKNAKKAVLSYGLFSVWIFGNYLPLFTDYEGYFAQRADYGQAYIDAVSKLMPLWMAPVLLAVCLVCGILGGLLGKALLKKHFEKAGLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JN2</accession>
    <name>DDL_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="2">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ddl</name>
        <name type="ordered locus">TDE_2385</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972984.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680316.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JN2"/>
    <dbReference type="SMR" id="Q73JN2"/>
    <dbReference type="STRING" id="243275.TDE_2385"/>
    <dbReference type="EnsemblBacteria" id="AAS12903">
        <property type="protein sequence ID" value="AAS12903"/>
        <property type="gene ID" value="TDE_2385"/>
    </dbReference>
    <dbReference type="GeneID" id="2740687"/>
    <dbReference type="KEGG" id="tde:TDE_2385"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2253"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_0_0_12"/>
    <dbReference type="OMA" id="NTTPGMT"/>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000341191" description="D-alanine--D-alanine ligase">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="141"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="176"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <sequence length="368" mass="41197" checksum="231B8CE39A55FD34" modified="2004-07-05" version="1">MNIAIIYGGKSSEHEVSLQSASSIIRTIDKKHKLHLIGISKNGAWYLHGDEERERIIKNEKAVLKIKKDEAKRVTVIPGGGAKKGLKAGDEFLPTDAVFAVLHGRFGEDGTIQGLFEMADLPYVGGDVMSTSISMDKEKTKMIWDYSGLPIVPYIAIKRQDWDDPEKKKAILARAEKDLEYPLFIKPCRAGSSVGAGMVKNRNELLEQAEESFLWDNKILVEACIEAREVECSVTGNTKTVAYIPGEIIPTHKFYDYEAKYTDPNGAELKIPADLNETQRKTIRETAIKAYEALDLSGLSRVDFFIDKRTGKIYLNEVNTIPGFTAISMFPKMCGASGLPYNELIMHLIELAIDRFKTDRKLKTCRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JP1</accession>
    <name>Q73JP1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973040.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2441"/>
    <dbReference type="EnsemblBacteria" id="AAS12959">
        <property type="protein sequence ID" value="AAS12959"/>
        <property type="gene ID" value="TDE_2441"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2441"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2309"/>
    <dbReference type="HOGENOM" id="CLU_3190267_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="46" mass="5053" checksum="BCC1964A1A133BC4" modified="2004-07-05" version="1">MQVMAITFNICGGIQTTNRNFKCDGIKMSGNKAGDGGDDFFRFESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JP3</accession>
    <name>Q73JP3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_2439</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973038.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680378.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2439"/>
    <dbReference type="EnsemblBacteria" id="AAS12957">
        <property type="protein sequence ID" value="AAS12957"/>
        <property type="gene ID" value="TDE_2439"/>
    </dbReference>
    <dbReference type="GeneID" id="2739864"/>
    <dbReference type="KEGG" id="tde:TDE_2439"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2307"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053520_0_0_12"/>
    <dbReference type="OMA" id="HGMERTH"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="363" mass="39802" checksum="95D05BC0B20C4D33" modified="2004-07-05" version="1">MEKNKLAELKTSISNAAEKVMDEIITICNIPSPTGYTCEAADYVLKRLSGLGFKPWLTNKGAVVCELDKNAEPNTGKKGDKALLLSAHIDTLGLFVRHIKSSGRLRTSLDGGFPYNYVEQSNVTVITREGKKYEGTMRLTEPAVHASREINELKRDDSNMELVLDEIVKSREDVEKLGIMAGDVVAIESLARKAGNGFLKSRHLDDKASCGMFIYLAEQVAKGELKLKRKTYIMFTNYEEIGHGASAGHPEGISDMLAVDMGVVGSDLDTDEYAVSICAKDSSGPYNYEFTSELIKIAKEMELNFAVDVYPFYGSDASAALKAGYDYRHALVGTGVAASHGYERIHKQGLENTLLLLTAYISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JR3</accession>
    <name>Q73JR3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973069.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2471"/>
    <dbReference type="EnsemblBacteria" id="AAS12988">
        <property type="protein sequence ID" value="AAS12988"/>
        <property type="gene ID" value="TDE_2471"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2471"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2337"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_21_3_12"/>
    <dbReference type="OMA" id="TFLAVQY"/>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="71"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="214"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="360" mass="39789" checksum="A5D5351B28E12A91" modified="2004-07-05" version="1">MFQHRTIFCLYKFRLVFFFVFLYNADLSYNTPFQKGKLVPGLFEAFCICRFTDDAKEFILTNTKINVLSRLALLIVAIVWGSSLVVVSETTDFFKPNFLLGLRFSIACFLLCLVFYKKLKLIDKDYLINGGIVGFFLFIAYSSQTFGVTTAGGLPGRSAFLSASYCVIVPFLGWLVNRIRPDRYNASAAVLCILGIGLVSFKDLVLSSSVGITLGDFYALLSGLLFASHIVSITRLSKRKDPILMTIIQFGAAAILSWLVTLIFEDNSAIVWSYSSVGSVLYLAAICTGLALLLQNIGQKHTDASSAAIILGLESIFGIIFSVIFKGESLDVYSVFGFILIFIAIIISETKLSFLKKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JU4</accession>
    <name>Q73JU4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973089.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680465.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2491"/>
    <dbReference type="EnsemblBacteria" id="AAS13008">
        <property type="protein sequence ID" value="AAS13008"/>
        <property type="gene ID" value="TDE_2491"/>
    </dbReference>
    <dbReference type="GeneID" id="2741464"/>
    <dbReference type="KEGG" id="tde:TDE_2491"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2357"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044815_1_0_12"/>
    <dbReference type="OMA" id="MQTPPMQ"/>
    <dbReference type="OrthoDB" id="1529383at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="103"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS13008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="264" mass="29528" checksum="6A2278CD7AF8493A" modified="2004-07-05" version="1">MKAEEKKTLYTFFRTASEYLSGFKTDEEYPDFADTVLSETAIPDTALPETDEAAGLTIPLSDTDSESGFESLEKVYAQIASCKACRLCERRHNTVAGEGPCEFSNFDNKIEVMVIGEGPGADEDAQGRPFVGKAGQLLDKMLAAIELYRTHNCYITNVVKCRPPNNRDPLPDETAACRNYLNAQIALIRPKAILVVGRVALQNLLETQEGIGKMHGKFFEYQNIPLMATYHPSALLRDVNLKRPAWEDLKLFRSRLNELSQQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JW3</accession>
    <name>Q73JW3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_2524</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973122.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2524"/>
    <dbReference type="EnsemblBacteria" id="AAS13041">
        <property type="protein sequence ID" value="AAS13041"/>
        <property type="gene ID" value="TDE_2524"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2524"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2388"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_9_12"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="175"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="209"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS13041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="423" mass="47711" checksum="7F7D2188A2943D3E" modified="2004-07-05" version="1">MIAFNIISFYLAKYIYKKFGDHISGEVKKSARYIKSYMNLIYDYRTGKDIRLYDKALAEKYTGTYLAMQKSTHDFMAKFFSRTIGSAKLLEGSLLLLVFLFVGLKAVYGSIALSEVFFFIGAINVFSAQVSEAMDGLTTLVASDKSRKKLLNFLDIDEKKYSGKLSINKDEPIVFELKNISFKYPDRDKYALKNINLKIDSSQKLAMVGKNGSGKTTLIKLLVRLYEPTEGEILLNGVNIKEYDYDEYIDVFSVVFQDFKLLSLKLGENVSASSSYDEKKVADALSKTGMEAFYKKHGAEAYLYQNFDIGGIEASGGEAQKIAMARAIYHGGKIFILDEPTAALDPISEAEIYSHFDNITSKNTAIYISHRLSSCKFCDKIAVMDEGSLVQYGNHNELVSDINGKYYELWNAQAKYYQEDKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JX2</accession>
    <name>Q73JX2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973113.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73JX2"/>
    <dbReference type="STRING" id="243275.TDE_2515"/>
    <dbReference type="EnsemblBacteria" id="AAS13032">
        <property type="protein sequence ID" value="AAS13032"/>
        <property type="gene ID" value="TDE_2515"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2515"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2381"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_1_0_12"/>
    <dbReference type="OMA" id="WHEVRTW"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="77"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="361" mass="38870" checksum="7C85B32783493CC8" modified="2004-07-05" version="1">MAAALLFTGCNQPSGSSSGGGNSGGGGGGTPPTPPAPPEIVYEFVEISEVTITGNEVDPSTLPEDEDWLKGVFIKDRKVKLSPYKLGKTEVTYELWHEVRTWAESKGYTFANKGLEGWDGTGGGGSFPNYANIGKLPTANKNHPVTTISWRDCIVWCNAYTEMKMGKDECVYRKSKTDSTVLKDATDGAVCDAAYADMSKKGFRLPTEAEWEYAARRQGNDTTNAAQYGDVWLTKLNSASGAKDKWDTAETGEVAWYSGNSGYKTHPVGKKRENALGLHDMSGNVWEWCFDRHNNDPASNDGSYVQGGIVTDPQGAASGSNRVLRGGSWDNYAEGCTVGTRGNGNPGNRGNLLGFRLACRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K09</accession>
    <name>Q73K09_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973154.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680529.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2556"/>
    <dbReference type="EnsemblBacteria" id="AAS13073">
        <property type="protein sequence ID" value="AAS13073"/>
        <property type="gene ID" value="TDE_2556"/>
    </dbReference>
    <dbReference type="GeneID" id="2739921"/>
    <dbReference type="KEGG" id="tde:TDE_2556"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2416"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_966257_0_0_12"/>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="281" mass="33066" checksum="F164929391460D38" modified="2004-07-05" version="1">MKEEFLNPKMDWVFKLMFSKGKKGNKALISFLNAFLEDSYGKIKKADILNTELIRETPNGETYHLDFLIKTDTGLIIDLEMQQFWKENYPRRSQMYLLRLASRFLKLESKKDDPFYAVSISVFGCNVPKNAKLVKMSENSVIQYIYIELNELIGYTIKKSLEDYTLKDFWIRFLTTYEQDKKSGVLKKLCELEEGIRMAEETILRVTEEERRIARELSREKYQMLLEAERGDARREGRAEGFADGEYQAKLDMAKLMKTMNYSIDDIHKITGLAIQEIKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K14</accession>
    <name>Q73K14_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973175.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680561.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2577"/>
    <dbReference type="DNASU" id="2741281"/>
    <dbReference type="EnsemblBacteria" id="AAS13094">
        <property type="protein sequence ID" value="AAS13094"/>
        <property type="gene ID" value="TDE_2577"/>
    </dbReference>
    <dbReference type="GeneID" id="2741281"/>
    <dbReference type="KEGG" id="tde:TDE_2577"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2436"/>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124456_3_1_12"/>
    <dbReference type="OMA" id="QYYSAIE"/>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="137" mass="15674" checksum="9A6993FA134E32E2" modified="2004-07-05" version="1">MIKRVFIDTDIILDVALAREPFFTASKIILAMAENNIIIGNISSNCVANIYYILRKSGGDNKARKFILNIVKYITVIVINHRNVLDSLRSKFSDFEDALQHSSAVENQCEYIITRNIEDYKNAKIKVLLPEEFIGMF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K74</accession>
    <name>NTPPA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="1">dTTPase/UTPase</shortName>
            <ecNumber evidence="1">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="1">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_2348</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972947.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680263.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73K74"/>
    <dbReference type="SMR" id="Q73K74"/>
    <dbReference type="STRING" id="243275.TDE_2348"/>
    <dbReference type="EnsemblBacteria" id="AAS12866">
        <property type="protein sequence ID" value="AAS12866"/>
        <property type="gene ID" value="TDE_2348"/>
    </dbReference>
    <dbReference type="GeneID" id="2739957"/>
    <dbReference type="KEGG" id="tde:TDE_2348"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2216"/>
    <dbReference type="eggNOG" id="COG0424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_0_12"/>
    <dbReference type="OMA" id="RIDGDFY"/>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000267459" description="dTTP/UTP pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <sequence length="203" mass="22707" checksum="4C572662BCD3F6C5" modified="2004-07-05" version="1">MKELILASASPRRKEILDSLGVLFSVKISNFDESSITEKDPVKRCILTARGKAENLFKTLPQNEGAQKLILAADTLVFAENTAFPNEKIIFGKPKNEKEAEMMLKSHSGSLHFVVSAICLLDCKTGQINEKHSVSKVFFKKLSDKEISAYLKTDEWKDAAGAYKIQGKASFFIEKIEGSYTGIVGLPVRELYEILNKTEFRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K84</accession>
    <name>Q73K84_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium/dicarboxylate symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2336</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972935.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002683949.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2336"/>
    <dbReference type="EnsemblBacteria" id="AAS12854">
        <property type="protein sequence ID" value="AAS12854"/>
        <property type="gene ID" value="TDE_2336"/>
    </dbReference>
    <dbReference type="GeneID" id="2739431"/>
    <dbReference type="KEGG" id="tde:TDE_2336"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2205"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
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        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF118215"/>
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    </dbReference>
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            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
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        <location>
            <begin position="340"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="423" mass="45201" checksum="C6B776CD8725E993" modified="2004-07-05" version="1">MNKKLVWMIFIAFIIGLVVGIVLWQTGVDVGGYVTWVSPFGNILVSMLKMIVIPVIFLSLISGAASLPTKEFGKIGVKVVVWYFVTSLFAAIVGSFLALAFNPGSGTSHSEWASLMSMGSAEIAPASAGSLADVFLDMFQNPFKALAQGNFLAIIVFAIAFGIALKIISEKNDAKLQEGAKLFLNIVETCKETVFKMVDWILAYSPIGVFCLTSVNFAQYGSKLFGPYIMLTLGVVLGIIAMVFIVYPIMIAVSTRKNPIKIMMQIREPMLTAFVTRSSAASLPVSLRTAKENLHISDNLSSFALPLGSTVNMDGVCVHLPMFAVLAANMFGADIGFTALLVLVITTVLASVGAGGVPGGSLMLLFIILQNMNLDPGQIAIIVGLALGINPILDMFETMNNVAGDLVCTYCVADMSDMIEKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K94</accession>
    <name>Q73K94_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972925.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002688425.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2325"/>
    <dbReference type="EnsemblBacteria" id="AAS12844">
        <property type="protein sequence ID" value="AAS12844"/>
        <property type="gene ID" value="TDE_2325"/>
    </dbReference>
    <dbReference type="GeneID" id="2739420"/>
    <dbReference type="KEGG" id="tde:TDE_2325"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2194"/>
    <dbReference type="eggNOG" id="COG3314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_717532_0_0_12"/>
    <dbReference type="OMA" id="WITGNEV"/>
    <dbReference type="OrthoDB" id="819609at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="381" mass="40251" checksum="C8E2F5891557D4D0" modified="2004-07-05" version="1">METKSFFKKEIGAENFIFLALFSAFFFGVGSVMGGVNMIKTMMETGFDLLINICLYLMAVAVLAGAVSGLFSEFGTIALINKILSKLMKPLYDLPGASSLGILNCFLSDNPAILTLADDDNFRRYFKQYQLPALTNLGTAFGMGLITTTAMMGLNIKSAVPAALIGNVGAIAGSIVSVRLMIYFSKKRYGTEAFVSTKRVDPIPEKMRPVREGGAGGRFIQAMLDGGKSGVSMGLAIIPGVVIICTIVIMLTNGPSADGTYTGGAREGIAVLPWIGQKLSFILNPMYGFSSPEAISVPITALGSTGAALGIVKEMSFAGKINANDIAVFTAICMCWSGYISTHIAMMDALDTKEMTGKAILSHTIGGLFAGIVAHLIAFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KB5</accession>
    <name>Q73KB5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972904.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667809.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2304"/>
    <dbReference type="EnsemblBacteria" id="AAS12823">
        <property type="protein sequence ID" value="AAS12823"/>
        <property type="gene ID" value="TDE_2304"/>
    </dbReference>
    <dbReference type="GeneID" id="2740269"/>
    <dbReference type="KEGG" id="tde:TDE_2304"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2174"/>
    <dbReference type="eggNOG" id="ENOG5031DMB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2738869_0_0_12"/>
    <dbReference type="OrthoDB" id="2073265at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="71" mass="8179" checksum="1CF47D72ED91EC50" modified="2004-07-05" version="1">MTSVNLFPPKKNTSTHNTVLTDEEIHAMELKLEDPEYINAAIYRLASIITERVLNGGLDYENMDCKKRIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KB8</accession>
    <name>Q73KB8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FlhB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972901.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667815.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2301"/>
    <dbReference type="EnsemblBacteria" id="AAS12820">
        <property type="protein sequence ID" value="AAS12820"/>
        <property type="gene ID" value="TDE_2301"/>
    </dbReference>
    <dbReference type="GeneID" id="2740266"/>
    <dbReference type="KEGG" id="tde:TDE_2301"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2171"/>
    <dbReference type="eggNOG" id="COG2257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041013_4_2_12"/>
    <dbReference type="OMA" id="PQLYAVI"/>
    <dbReference type="OrthoDB" id="1823885at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="87" mass="9561" checksum="8A9AA0B124D9A260" modified="2004-07-05" version="1">MTKTDKKKVDCAVALSYALEAKAPIITASGRGLTAKRIKEAAERNKIKIVEDETLANILIHHEIGSCIPEYTYKAVAAIFAFLLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KG3</accession>
    <name>Q73KG3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_C39_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972855.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2255"/>
    <dbReference type="EnsemblBacteria" id="AAS12774">
        <property type="protein sequence ID" value="AAS12774"/>
        <property type="gene ID" value="TDE_2255"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2255"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2128"/>
    <dbReference type="eggNOG" id="COG3271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111161_0_0_12"/>
    <dbReference type="OrthoDB" id="1746469at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_C39_2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="170" mass="19824" checksum="6D4910C8A36E50D7" modified="2004-07-05" version="1">MSEIYYRQTFNNCAPYSAMAAINIITKKEIYPELLARETGWRIKNNLTMPQGLIQVLHKHGIKTKEAVLSCCSDNEKINWIKNTVDEGKPIILLIKIKKVLHYVTVIGYDEKGFILYDSLQEKTKSNPRKTIKDKPQYYGNRYYEYSGLIKLWDKGGYKIFFKNWALVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KL1</accession>
    <name>Q73KL1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AcnX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972807.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680050.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2207"/>
    <dbReference type="EnsemblBacteria" id="AAS12726">
        <property type="protein sequence ID" value="AAS12726"/>
        <property type="gene ID" value="TDE_2207"/>
    </dbReference>
    <dbReference type="GeneID" id="2739483"/>
    <dbReference type="KEGG" id="tde:TDE_2207"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2084"/>
    <dbReference type="eggNOG" id="COG1679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018825_1_0_12"/>
    <dbReference type="OMA" id="YINAMVG"/>
    <dbReference type="OrthoDB" id="1159371at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01355">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007506">
        <property type="entry name" value="AcnX_catalytic_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04412">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcnX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="422" mass="47002" checksum="891B2BD0E14622D6" modified="2004-07-05" version="1">MQLTREQEEILNGSQGEMQAKVLKTLVMYGEAFGAERLVKVTGKYGHLVTSFGIGVMKPVYKLMDELLQSEAVSGIPFTVDPRPLDDVVPKSFLERLVFHFMYSKQEEYEKQLKAMGLLSDDAYTCTCYFDEVGNTPKKGEILSWAESSAVNYANSVLGAMCNRNSGIIEMFGLIAGWVPEFGLLTDEGRKADLIVEVETETLPEAQLLGSAIGIKAVENVPYIKGLDRFLGRELNDEVKAYFKDMGAAMASNGAVGLYHVENLTPEAKESGASLIRKDAEVYTITESELLRIRSSYPDIRKNKNAPPGLCFIGCPHLSKEQLIKWTGIIEQKLKQNKKSKISIPTVMTSPRGVLKEFSKTEEYKKLKSFGLLFSETCPLMYMNNPLCAKKSVITNSNKLRTYTTAVYYKDDEIADLITGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KL8</accession>
    <name>Q73KL8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamate racemase</fullName>
            <ecNumber evidence="2">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972800.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2199"/>
    <dbReference type="EnsemblBacteria" id="AAS12719">
        <property type="protein sequence ID" value="AAS12719"/>
        <property type="gene ID" value="TDE_2199"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2199"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2075"/>
    <dbReference type="eggNOG" id="COG0796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1213765_0_0_12"/>
    <dbReference type="OMA" id="IIYCNSL"/>
    <dbReference type="OrthoDB" id="1718671at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="224" mass="25617" checksum="AEA361FDE5C51B58" modified="2004-07-05" version="1">MDTRMGVELLERRDIEALAIPISSTCEEQSQLQYFSQEALENLFIKNSNEAIKKGADIIVIYCNSLSSAIDYEKIQRLLNIQIFSPLDTYKKLTDDCKNIAILAANGLAAYTIDKIIQKYNREKNTIPIGNMSIVQLIENGLPPAEIIKLLNLKGFLSYLENIEINDYKIDSLMLGCTHFPYIKNELQKHTSIRIVDPAEKMLETILHTKEKKEYAKKNSNNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KP0</accession>
    <name>Q73KP0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972778.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2177"/>
    <dbReference type="EnsemblBacteria" id="AAS12697">
        <property type="protein sequence ID" value="AAS12697"/>
        <property type="gene ID" value="TDE_2177"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2177"/>
    <dbReference type="HOGENOM" id="CLU_189759_0_0_12"/>
    <dbReference type="OrthoDB" id="1511407at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="74" mass="8653" checksum="E1831B8EF920FC2E" modified="2004-07-05" version="1">MKKDISENPPRYLVFFKGRDADVMEPAFKEYMAKNLRKEKKPSVKKALSAFKEAAKKNHKTREKVKVKDRGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L26</accession>
    <name>Q73L26_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Lipoprotein releasing system, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_2039</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972642.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679814.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2039"/>
    <dbReference type="EnsemblBacteria" id="AAS12553">
        <property type="protein sequence ID" value="AAS12553"/>
        <property type="gene ID" value="TDE_2039"/>
    </dbReference>
    <dbReference type="GeneID" id="2740633"/>
    <dbReference type="KEGG" id="tde:TDE_2039"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1924"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_1_12"/>
    <dbReference type="OMA" id="ERTQMIG"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="30"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="313"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="448" mass="48966" checksum="575707F7038ABF72" modified="2004-07-05" version="1">MKNLVFIKMAFRFLGIGSGKTVSNARKSLFGAVLGIGISIIPLIVVLVVSDGMIQGITSRTIELGTGHLQVINMRSISSYKNAETEKNVRSLILEFDEGNFVENAWIERQGNGLVIGKNGRSGGAIRAVEPEFFTQNIRALNLIKVISGSLEFENNKSAILGTAIAEKLGLKVGDTCRIITISKNEKGKTIPRVSSFKISGLVSSGYQELDALWVFIPLEEGLKIMPMSSSLTSIVVSTNDPFDEDKMQALQLKLNSILPESFSIYSWADLNRSAFTSFKTTKNILLFIMFLIVLVASANISSAIVMLVMERRREIAILKAAGAHPSSISLAFLLAGLLTSLGGIILGMPLGILAAIHINEIFAYAEKILNHIQNFFYTFVYGTGGTGKPLEIHLLDPAYYLEYIPVKLNLFDLYTIAVSMLILSVVVCLIPAVRAGKEKPIEIMRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L47</accession>
    <name>Q73L47_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972621.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679787.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2018"/>
    <dbReference type="EnsemblBacteria" id="AAS12532">
        <property type="protein sequence ID" value="AAS12532"/>
        <property type="gene ID" value="TDE_2018"/>
    </dbReference>
    <dbReference type="GeneID" id="2740365"/>
    <dbReference type="KEGG" id="tde:TDE_2018"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1905"/>
    <dbReference type="eggNOG" id="ENOG5031D5H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_785117_0_0_12"/>
    <dbReference type="OrthoDB" id="2106441at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="320" mass="38307" checksum="F4701864E754B8A5" modified="2004-07-05" version="1">MKMLRNMIFIFMLVLLVSCTKRENNELDNSKILNNINLDSKKDDDIYDRGFLIKELKNNDLIPYDLAYLTKKPESIFVYVIKSEWALREAISDYEKYGESSGEIPKLENLGKREFIFERHYDYYGNYIYEKRKTVAGYIYESIKYDKYNRPIEKIEIYEDSYVKKLTSMIVIEYAPVKQSDNILEAKIYKADKNGDKREINIVRSGKKENIYFFNDNEFYFENNQITKINTPDKKWIFKYANNTFLSEIGISHAGVGYESIKMEYEKGELVRCINVFGKSKSRYKFIRYDKFGNWIEMQIFHGDNTDFTDTIIREIKYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L51</accession>
    <name>Q73L51_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972617.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679779.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2014"/>
    <dbReference type="EnsemblBacteria" id="AAS12528">
        <property type="protein sequence ID" value="AAS12528"/>
        <property type="gene ID" value="TDE_2014"/>
    </dbReference>
    <dbReference type="GeneID" id="2740361"/>
    <dbReference type="KEGG" id="tde:TDE_2014"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1902"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865842_0_0_12"/>
    <dbReference type="OMA" id="CHADITE"/>
    <dbReference type="OrthoDB" id="1661508at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="328" mass="37728" checksum="38C7CE2D43A3C530" modified="2004-07-05" version="1">MKIRKSNTSKIIFILLCSFICLIIIFNPVTLYTVGWLSVKIMGSMGNLFNSADPSISINIFKNTPAWDLAKAVNSQNIKKINQICSENKELINYREPLYGTPLLYWAIVNSKYNSAEILLKNGADPDLMQRASNNTPLHLAVGKRWKGKSIDMNENIKYTKLLLKYGADPNIPYFEESYGDRTVLMNAIFTGDSKLLVELLINNGADIDARRNAGTTAASLALRLKRYTIAHYLIVECHADITEACYDPMIDKNLYISRKEKIYPVNILRDYSWVFPLDSKEYKLKQDIIAEFKRQGVDYYATPISDRTKYHIKYTYPDNYEEMLEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L65</accession>
    <name>Q73L65_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein, HlyB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972603.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2000"/>
    <dbReference type="EnsemblBacteria" id="AAS12514">
        <property type="protein sequence ID" value="AAS12514"/>
        <property type="gene ID" value="TDE_2000"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2000"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1889"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OMA" id="LYMELLY"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="326"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="360"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS12514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="566" mass="64060" checksum="71ACC9706025997F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L91</accession>
    <name>MURG_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murG</name>
        <name type="ordered locus">TDE_1974</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972577.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957113.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73L91"/>
    <dbReference type="SMR" id="Q73L91"/>
    <dbReference type="STRING" id="243275.TDE_1974"/>
    <dbReference type="CAZy" id="GT28">
        <property type="family name" value="Glycosyltransferase Family 28"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12488">
        <property type="protein sequence ID" value="AAS12488"/>
        <property type="gene ID" value="TDE_1974"/>
    </dbReference>
    <dbReference type="GeneID" id="2741537"/>
    <dbReference type="KEGG" id="tde:TDE_1974"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1866"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037404_0_0_12"/>
    <dbReference type="OMA" id="AADMMLC"/>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000225110" description="UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <sequence length="391" mass="42630" checksum="512447E9FB05DB57" modified="2004-07-05" version="1">MKCVVFTGGGTGGHIFPGLAVAEALSSSLECRIVWIGSAKGVDRKIVESSELYSASPSVLEFIGIPAGKLRRYFSFQNFIDVFKVAAGFIKSFFILLKLKPVFVFSKGGFVSVPPCAAAKFLKIPVITHECDFSPGLATRINSKFANRILVSYQETAELLPASLRSKVICTGNPVRLSFYSGRPEKGRSFLNIKSNLPVLFVLGGSLGARQLNDLISDSIEYLVKHFVVVHQIGEANMDQGQKIKEGLLKSSPEFAENYKPYPFIKKEMADVLSLSSIVVSRAGANTVWESAAAGKPMILVPLEKGSSRGDQIENAEFFKKKGSAEILLGEDVRPDIFIRLLRDLGFEENISGNERLKNMAQASAALAGEKPALVIADFLKSFFTSKNEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LB1</accession>
    <name>Q73LB1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972557.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679671.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1954"/>
    <dbReference type="DNASU" id="2741517"/>
    <dbReference type="EnsemblBacteria" id="AAS12468">
        <property type="protein sequence ID" value="AAS12468"/>
        <property type="gene ID" value="TDE_1954"/>
    </dbReference>
    <dbReference type="GeneID" id="2741517"/>
    <dbReference type="KEGG" id="tde:TDE_1954"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1846"/>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166037_0_1_12"/>
    <dbReference type="OMA" id="ISEICHK"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="84" mass="9590" checksum="3C4BE1FD28456BB4" modified="2004-07-05" version="1">MMQIRPVSDLRNKFSEIENIIISNKSPVFLTKNGHGSMVLMSLDMYESLTDNVENRLDEADFQAASTNVRLSHKDVFSDIRSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LD5</accession>
    <name>Q73LD5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972533.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679631.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1930"/>
    <dbReference type="EnsemblBacteria" id="AAS12444">
        <property type="protein sequence ID" value="AAS12444"/>
        <property type="gene ID" value="TDE_1930"/>
    </dbReference>
    <dbReference type="GeneID" id="2740170"/>
    <dbReference type="KEGG" id="tde:TDE_1930"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1825"/>
    <dbReference type="eggNOG" id="ENOG502ZG03">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056949_0_0_12"/>
    <dbReference type="OMA" id="TIIMEAP"/>
    <dbReference type="OrthoDB" id="1485294at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="374" mass="42029" checksum="D32E09FCB489817F" modified="2004-07-05" version="1">MLFKGKNKFIFIGVIIILVIYIFAAAVPMRKDVYLMPKWSSPMPKVQTGQMYFGEAEASGDELKQKFAGKTPIPFSLGNLFGYFTEDGEILRVETAEERFSASFYAWTRYPQKPLFTDIYKPEEFDLEKPFLRIDKPGYVYLDKDRIFLFEPEGSSLSKYDNAGKKLWHYTHTFPITAFQSSKAGCVIGHSDGLLVCLDSDGNTLFSFYPGGSTYQAIMGAAISEDGKQVLCLCGLDKQRVALINISGRQHKIVFHSSFEEDLRRQAFASFDKAGHFAVFESAEGIGIIDCRNLTLSLIKEEGFIAGLGFQDKSSLLTVLLKKDDECSLLLINPPDLMIGKTKFKSENAFLIQKENKIYIGTDEKITALDIRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LF0</accession>
    <name>Q73LF0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alcohol dehydrogenase, iron-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1915</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972518.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679610.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1915"/>
    <dbReference type="EnsemblBacteria" id="AAS12429">
        <property type="protein sequence ID" value="AAS12429"/>
        <property type="gene ID" value="TDE_1915"/>
    </dbReference>
    <dbReference type="GeneID" id="2740413"/>
    <dbReference type="KEGG" id="tde:TDE_1915"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1812"/>
    <dbReference type="eggNOG" id="COG1979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_4_12"/>
    <dbReference type="OMA" id="GTLQMGY"/>
    <dbReference type="OrthoDB" id="717704at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990362">
        <property type="term" value="F:butanol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08187">
        <property type="entry name" value="BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044731">
        <property type="entry name" value="BDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43633">
        <property type="entry name" value="PTHR43633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="3">
        <location>
            <begin position="9"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="391" mass="42893" checksum="69D5A486B3C282EC" modified="2004-07-05" version="1">MYNFEFEVPVKILFGKGSIENLVPEILKYGKRVLLCYGGGSIKRMGLYDTIIKKLDQAGIFYKELSGISPNPRIEEVEEGIKIVREHKLDFILPVGGGSTIDCSKAVSAGVNYAGSAWDLITGKAEIKNVLPIGTVLTLSATGSEMNCGAVISNLKTKEKLGFGAPPLLPKFSVLDPEYTYSVPKNQTAAGTADIMSHTFECYFSLNDGAYLQDRFAESILKTCIEYGPLAIKNPESYEARSNLMWAGTWAINGLLSDGKKTAWSVHPMEHELSAFYDITHGVGLAILTPHWLRHCLNDKTVKKIADYGVNVWGLPKGEEVYKTAEKAIECTSDFFKSLGIPMTLKEAGIGEEHLKEMAEAAVAHRGKNGVIYGFQELRADDVYAIYKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LF1</accession>
    <name>Q73LF1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltrans_SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972516.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679607.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1913"/>
    <dbReference type="EnsemblBacteria" id="AAS12427">
        <property type="protein sequence ID" value="AAS12427"/>
        <property type="gene ID" value="TDE_1913"/>
    </dbReference>
    <dbReference type="GeneID" id="2740411"/>
    <dbReference type="KEGG" id="tde:TDE_1913"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1810"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_1_1_12"/>
    <dbReference type="OMA" id="LMKWAKR"/>
    <dbReference type="OrthoDB" id="468283at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltrans_SAM" evidence="4">
        <location>
            <begin position="64"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="335" mass="39368" checksum="0214D9908A76C727" modified="2004-07-05" version="1">MQKNQYQAELFKNRLQKRFKHLLKWAKREGVFAYRLYDKDIPEIPLAVDIYFAETEETEKRAFLLIYLYKRPYEKSQEEEREWLLVIEEAASSSLLIPKERIFIKLREKQKGKSQYEKAGSSKNLIRVKEGECFFYVNVEDYLDSGLFLDHRPARSMVFKEAKNKKVLNLFSYTGSFSVHAAKGGAASVDSVDLSNTYLNWAKENLKLNKLFDEEKTQLIKSDVIVFLKKAIEEQKKWDLIICDPPTFSNSKSADIFDVNRDWLKLCLLCLKVLSKNGKLYFSTNSQKIKFDEAELINFSEQKIRVKDITKASIPEDFRNQKIHKMWMIEAGYLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LJ8</accession>
    <name>RUVC_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="1">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvC</name>
        <name type="ordered locus">TDE_1864</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972468.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679556.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73LJ8"/>
    <dbReference type="SMR" id="Q73LJ8"/>
    <dbReference type="STRING" id="243275.TDE_1864"/>
    <dbReference type="EnsemblBacteria" id="AAS12379">
        <property type="protein sequence ID" value="AAS12379"/>
        <property type="gene ID" value="TDE_1864"/>
    </dbReference>
    <dbReference type="GeneID" id="2740053"/>
    <dbReference type="KEGG" id="tde:TDE_1864"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1769"/>
    <dbReference type="eggNOG" id="COG0817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091257_3_1_12"/>
    <dbReference type="OMA" id="AICHIWR"/>
    <dbReference type="OrthoDB" id="1815080at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000225186" description="Crossover junction endodeoxyribonuclease RuvC">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <sequence length="178" mass="19095" checksum="EE9C83F73701E2C8" modified="2004-07-05" version="1">MGILKAASSKKNLRPCVIGIDPGLANTGYGIISFSNNRFECIEYGSISTEPHLLQGERLLKIFDKVSELIEKYRPKEAGIETLYFAKNATSAMSVSEARGVVLLALAQGGVRVGEYAPNSIKKAVTGIAQAEKRQVQEAVKLILGLKEIPRPDHAADALAAAITKINLGDVGEVRAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LK9</accession>
    <name>Q73LK9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972457.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1853"/>
    <dbReference type="EnsemblBacteria" id="AAS12368">
        <property type="protein sequence ID" value="AAS12368"/>
        <property type="gene ID" value="TDE_1853"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1853"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1758"/>
    <dbReference type="HOGENOM" id="CLU_3334247_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="38" mass="4700" checksum="97C7653400A703CD" modified="2004-07-05" version="1">MLVLIFYDIMNIEKLQLFDVFLRFICDVFHKYLCINDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LV1</accession>
    <name>Q73LV1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2087 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972365.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679502.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1761"/>
    <dbReference type="EnsemblBacteria" id="AAS12276">
        <property type="protein sequence ID" value="AAS12276"/>
        <property type="gene ID" value="TDE_1761"/>
    </dbReference>
    <dbReference type="GeneID" id="2740606"/>
    <dbReference type="KEGG" id="tde:TDE_1761"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1683"/>
    <dbReference type="eggNOG" id="COG3860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146519_0_0_12"/>
    <dbReference type="OMA" id="DREDNMY"/>
    <dbReference type="OrthoDB" id="1985985at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018656">
        <property type="entry name" value="DUF2087"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09860">
        <property type="entry name" value="DUF2087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2087" evidence="1">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="96" mass="11656" checksum="047598D4EF29CB4F" modified="2004-07-05" version="1">MNLPILKEQISQFLDEEGRIVRWPKKTYDKINVLKYLQGKFDPNKKYSEVEVNAVLKTWHTFNDHALLRRELFDKFLLERTPDCKEYWVNTNKIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LX1</accession>
    <name>Q73LX1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_1741</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972345.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679459.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73LX1"/>
    <dbReference type="STRING" id="243275.TDE_1741"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12256">
        <property type="protein sequence ID" value="AAS12256"/>
        <property type="gene ID" value="TDE_1741"/>
    </dbReference>
    <dbReference type="GeneID" id="2739199"/>
    <dbReference type="KEGG" id="tde:TDE_1741"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1664"/>
    <dbReference type="eggNOG" id="COG5009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_4_12"/>
    <dbReference type="OMA" id="YQLTSMM"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="58"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="415"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="815"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS12256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="846" mass="94314" checksum="4C229F73B07CEFF7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M02</accession>
    <name>RS20_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsT</name>
        <name type="ordered locus">TDE_1710</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972314.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669392.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M02"/>
    <dbReference type="SMR" id="Q73M02"/>
    <dbReference type="STRING" id="243275.TDE_1710"/>
    <dbReference type="EnsemblBacteria" id="AAS12225">
        <property type="protein sequence ID" value="AAS12225"/>
        <property type="gene ID" value="TDE_1710"/>
    </dbReference>
    <dbReference type="GeneID" id="2740882"/>
    <dbReference type="KEGG" id="tde:TDE_1710"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1635"/>
    <dbReference type="eggNOG" id="COG0268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160655_3_1_12"/>
    <dbReference type="OMA" id="SMIRTMA"/>
    <dbReference type="OrthoDB" id="2005443at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000168052" description="30S ribosomal protein S20">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="89" mass="9987" checksum="AFDF10A12840C02B" modified="2004-07-05" version="1">MKNRSAIKRHNQSEVRRMRNRSAKSEVRTTARKYTEAVHAANAENAAALLRELSSQLDSAARKGILTKNSAARKKSRMQLLYNASFAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M23</accession>
    <name>Q73M23_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972292.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679395.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1688"/>
    <dbReference type="EnsemblBacteria" id="AAS12203">
        <property type="protein sequence ID" value="AAS12203"/>
        <property type="gene ID" value="TDE_1688"/>
    </dbReference>
    <dbReference type="GeneID" id="2740143"/>
    <dbReference type="KEGG" id="tde:TDE_1688"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1615"/>
    <dbReference type="eggNOG" id="ENOG502Z8T8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031634_0_0_12"/>
    <dbReference type="OMA" id="KWQDVTQ"/>
    <dbReference type="OrthoDB" id="1979475at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="566" mass="63196" checksum="738E5F297F191FC6" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M48</accession>
    <name>Q73M48_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">dnaB</name>
        <name evidence="14" type="ordered locus">TDE_1662</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 12"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972267.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669313.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1662"/>
    <dbReference type="EnsemblBacteria" id="AAS12178">
        <property type="protein sequence ID" value="AAS12178"/>
        <property type="gene ID" value="TDE_1662"/>
    </dbReference>
    <dbReference type="GeneID" id="2739003"/>
    <dbReference type="KEGG" id="tde:TDE_1662"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1589"/>
    <dbReference type="eggNOG" id="COG0305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005373_0_0_12"/>
    <dbReference type="OMA" id="IEFHARI"/>
    <dbReference type="OrthoDB" id="1709134at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 12 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="13">
        <location>
            <begin position="181"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAS12178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="445" mass="49231" checksum="8876050B9A78336E" modified="2004-07-05" version="1">MDSVKNLKNKLPPHNMEAEKAVLGAILIDPDVFTFVRPILDASAFYSPQHQKIYKAISELDTQSQKADILILTDYLRSVNELDSVGGASYIASLTDEVPSSANYEFYAKIVLEAAIRRNLLKVSNKISADVFDDSISSRTVLEEAQKSIFDLTEAGNSATFKSLAEVIMPTLEVLQKLHERKGAYTGVPSGFGNLDNMTYGFQDSEFIIIGARPSVGKTALAMTMAAHIAIDEKIPTAFFSLEMSDMQLVQRLIASRAKINSNRIRSANLTARDFGKVSETCGMLYEAPFYLVDMPNMKLLDLRAIARQLCSPPYNVKIIFIDYITLITGENASIPRHEQIAEISRSLKSLARELNIPVVALSQLTRDAEGKKPGLADIRESGSLEQDADVVMFLHRERADTSEDEAKPIPTELILAKQRNGPIGTVPLLFLSQYTTFVTEAKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M79</accession>
    <name>Q73M79_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972236.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671050.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12147">
        <property type="protein sequence ID" value="AAS12147"/>
        <property type="gene ID" value="TDE_1630"/>
    </dbReference>
    <dbReference type="GeneID" id="2739739"/>
    <dbReference type="KEGG" id="tde:TDE_1630"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1558"/>
    <dbReference type="HOGENOM" id="CLU_801530_0_0_12"/>
    <dbReference type="OrthoDB" id="1900769at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="346" mass="41008" checksum="AFEF90A09DC5B377" modified="2004-07-05" version="1">MSAYFTIYPGNNRNILFGDLLEEFKKNIKDFFLKNDIHIDFNVYAGIYNTKRKQEDRINNNMPFRAPEANEVIWIAYEFMVCNQKITDFTHVDFYPFDDDICITSDYLFDGKQAMIPDIKERMPYIINTGGYWIFSGRAWPAYGFAAASFAKLTDGIIFSDTGAWDYSKFPCFAKDFLKFYYNINDLSNSDYDITETKWYIKKIKTYDYAINGRIKTYPNVKYNFDNLYIARLFLDFHYDIKPCLYDSHSYTKYMEINGDKTLLYFLNGDTPIKIDIIIDNVNKSKNTRVLCFVDNRSLLFYEKHNEKYAERIKLKLYSLSKGAKKYKRNLQTVYFVSGDEILVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M93</accession>
    <name>Q73M93_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerate dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.29</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hprA</name>
        <name evidence="6" type="ordered locus">TDE_1616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.29" evidence="6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972222.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679304.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1616"/>
    <dbReference type="EnsemblBacteria" id="AAS12133">
        <property type="protein sequence ID" value="AAS12133"/>
        <property type="gene ID" value="TDE_1616"/>
    </dbReference>
    <dbReference type="GeneID" id="2740857"/>
    <dbReference type="KEGG" id="tde:TDE_1616"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1545"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_12"/>
    <dbReference type="OMA" id="KMKPNCI"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008465">
        <property type="term" value="F:glycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="111"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="322" mass="35637" checksum="1F07EAEF59483A09" modified="2004-07-05" version="1">MSEKLNLVILDGFTSNPGDLSWDELKSVSNLTIYDKTSAEELLERCKEADAVLTNKVVFSKEIMDSLPRLKYIGVLATGYNVVDIEAARAKNICVTNIPSYSTDSVAQLVFALIFHFYWHVKEHSDEVMGGKWSASPHFCYHSFDIRELSDKTMGIVGFGNIGQAVAKIALAMNMKVIYFNRSKKNIKGLEEAKQVSLDELFSSSDIISLNCPLTPETKEIINAESLKKIKKTSIVINTGRGPLINEKDAAEALKEKRLAGLACDVLSVEPPAKDNPLLKAPNCIITPHMAWQTFEARERLIKTAAANAKAFIAGKEINRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MB0</accession>
    <name>Q73MB0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_1599</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972205.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679276.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1599"/>
    <dbReference type="EnsemblBacteria" id="AAS12116">
        <property type="protein sequence ID" value="AAS12116"/>
        <property type="gene ID" value="TDE_1599"/>
    </dbReference>
    <dbReference type="GeneID" id="2739796"/>
    <dbReference type="KEGG" id="tde:TDE_1599"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1529"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_12"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="31"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="332"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="364"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS12116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="574" mass="64344" checksum="951A80248F762DB0" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MB2</accession>
    <name>Q73MB2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1597</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972203.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679272.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1597"/>
    <dbReference type="EnsemblBacteria" id="AAS12114">
        <property type="protein sequence ID" value="AAS12114"/>
        <property type="gene ID" value="TDE_1597"/>
    </dbReference>
    <dbReference type="GeneID" id="2739794"/>
    <dbReference type="KEGG" id="tde:TDE_1597"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1527"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076847_2_0_12"/>
    <dbReference type="OMA" id="WIFTITT"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="235" mass="26829" checksum="53369C3B5B938426" modified="2004-07-05" version="1">MFKRCKRYGIKYDPRIKLLQVLLVSVFVFTLPGKKYEILLFLSVFIFAIMSGINKTAVKFLFVYSGLFIAAEISPLFIATTIHYFLLCFVTILFAATNLMRTAEISEILATLQNMKIPYYINIPLAVILRFFPTIKQDIVCIKQGIKTRGIDVSLLGVLKHPCKMYEMMLIPFLMRMLSTATELAASVETRGLGVSGKKTSYREVRFGMLDILLLIIMLVFYTAVVVMKIKNIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MF3</accession>
    <name>Q73MF3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972161.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679215.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1555"/>
    <dbReference type="EnsemblBacteria" id="AAS12072">
        <property type="protein sequence ID" value="AAS12072"/>
        <property type="gene ID" value="TDE_1555"/>
    </dbReference>
    <dbReference type="GeneID" id="2739305"/>
    <dbReference type="KEGG" id="tde:TDE_1555"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1491"/>
    <dbReference type="eggNOG" id="ENOG50349NF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1102397_0_0_12"/>
    <dbReference type="OMA" id="WEEDERC"/>
    <dbReference type="OrthoDB" id="1258661at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="252" mass="29157" checksum="9939202E7E5EC596" modified="2004-07-05" version="1">MKGKILKLLIIVIVIFNGACGTGVYEIVSRDQRDPDNFYVNVDSFSEENVIKCIWEEDERCDKYILMRSEDKNVLKFKEVYNGEGTEYEDRVLKEDTRYIYRLDKIRGKKRFLGNIHYMGIYSKQVKDVYEPNDRKEKAVLLQNDIQGNVYYYRSHEGTVLEDEDWYKVRIPAKRQATIAIVYDAANLPFIITKPYNGSSEKPANNVGIIIKNDTDVEKELSFKISLDRNIVVSGSAGGGCYPYTLRLISIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MH0</accession>
    <name>DNLJ_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ligA</name>
        <name type="ordered locus">TDE_1538</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide.</text>
            <dbReference type="EC" id="6.5.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972144.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679195.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MH0"/>
    <dbReference type="SMR" id="Q73MH0"/>
    <dbReference type="STRING" id="243275.TDE_1538"/>
    <dbReference type="EnsemblBacteria" id="AAS12055">
        <property type="protein sequence ID" value="AAS12055"/>
        <property type="gene ID" value="TDE_1538"/>
    </dbReference>
    <dbReference type="GeneID" id="2740900"/>
    <dbReference type="KEGG" id="tde:TDE_1538"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1475"/>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007764_2_3_12"/>
    <dbReference type="OMA" id="HDVEHEI"/>
    <dbReference type="OrthoDB" id="241401at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
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        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000313497" description="DNA ligase">
        <location>
            <begin position="1"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="564"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <sequence length="645" mass="71748" checksum="E91A178CAB2ABC84" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MI0</accession>
    <name>Q73MI0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972134.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679174.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1528"/>
    <dbReference type="EnsemblBacteria" id="AAS12045">
        <property type="protein sequence ID" value="AAS12045"/>
        <property type="gene ID" value="TDE_1528"/>
    </dbReference>
    <dbReference type="GeneID" id="2740890"/>
    <dbReference type="KEGG" id="tde:TDE_1528"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1465"/>
    <dbReference type="HOGENOM" id="CLU_731459_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="378" mass="43541" checksum="1A58EF86D9A27676" modified="2004-07-05" version="1">MDFYIFEKNEKQLYKVCWSLAIGVWFLYLSSAYRSSGGNIKFSILLFPQNMVFIIFGIFQAYNFYEIKKVINEEYTNHKGFKEPAYISYIRLIADSLIYTSFYTIVLFPISGIGIVEYVIVAIVIFFDFLYKVVPKIKSFEISIGQSPILVLSFGVLLFLIKIIVFYLFPDNIYNELFVGNSTARWLIAIIGGGGIILLLSQLKTRVFGGTKTANRLFTKIIGLFVKLFTFVGTTLCLICSPIVLLGITAITIIGGLFFIESIKNDIIKLLEPFLQKILTTGENKVQISNLYQVFQMISFVLILFHQLLSYFNLRKKAMEVAHKKSKWITNRPDLSADFKEIIDYDIRNNPILFVTKYDIYKKKCLEANTKTNLERIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MI8</accession>
    <name>Q73MI8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hydro-lyase, tartrate/fumarate family, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972126.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671202.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1520"/>
    <dbReference type="EnsemblBacteria" id="AAS12037">
        <property type="protein sequence ID" value="AAS12037"/>
        <property type="gene ID" value="TDE_1520"/>
    </dbReference>
    <dbReference type="GeneID" id="2739726"/>
    <dbReference type="KEGG" id="tde:TDE_1520"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1459"/>
    <dbReference type="eggNOG" id="COG1951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041245_0_0_12"/>
    <dbReference type="OMA" id="IETYPTH"/>
    <dbReference type="OrthoDB" id="972093at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="281" mass="30771" checksum="2B3111E80420D5E4" modified="2004-07-05" version="1">MHIVEAKKITEEVKRMAIEAAYYLPQDVLTSLKMSREAEKWSLARDTLDQIIENADIAKNTNSPMCQDTGMAVVFVTIGQDVHIEGGYIEDAINEGVRQGYTEGYLRKSVVADPVYNRVNTKDNTPAVIHYNIVPGDKLHIMFAGKGFGSENMSRLGMLKPSDGLEGVKKFILETVELAGPNPCPPIVVGVGIGGTVDKVTLIAKKALMRPMDSYNPDPFYANLEKEMLEKVNALGIGPQGYGGKTTALRVLIETYPTHIAGLPICVNINCHATRHKEVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ML0</accession>
    <name>Q73ML0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YfiO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972104.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1498"/>
    <dbReference type="EnsemblBacteria" id="AAS12015">
        <property type="protein sequence ID" value="AAS12015"/>
        <property type="gene ID" value="TDE_1498"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1498"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1437"/>
    <dbReference type="eggNOG" id="COG4105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_553143_0_0_12"/>
    <dbReference type="OMA" id="PTPHRQS"/>
    <dbReference type="OrthoDB" id="1779689at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YfiO" evidence="2">
        <location>
            <begin position="413"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="501" mass="55182" checksum="86993BC642E48E08" modified="2004-07-05" version="1">MNSCASTKKNTGETLDKKTENIAVNEPKTETDKESDTDTSKDSENAKNSEKIIIMKVPEAESVESVSDPKPVADKPALELIVDTEDENELASSNNEAGSSKDTDSKLPSVIEPEPLKKPEEKKPQDSAPSTSNQATISVPDKKQIVKPADDPNKVTKPEIKKESLEKPVISSDKAPTAAETKPSIPEVSGVNDKNIVNEEKIKDGSEPARVFSEFPSTEPDDSKEEKASRSVKLYTGQRLEVVYPGEGWVYLGESTAQKGIKYQQRKLQSGTSIFHFGAGDEGSYILNFSYFDVFSDNFISDSIAVHVEKAKTKLNNTVKAPDYKGPINAQKENKPDLKNESKYGTDKGKVNNDTSSSKTLDEVSAGTPLKAESSVKKRENSKVYDAPDLLTVTEKSESKTSGQDFKSASELLDMIRGYISEGNAASALNSAEDFFKNYSVNLDEALFLRGQAYELNGPNKNIKKALEAYQTLTKAYPESKFWDKADARIRYIKKFYIDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MN2</accession>
    <name>Q73MN2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972082.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1476"/>
    <dbReference type="EnsemblBacteria" id="AAS11993">
        <property type="protein sequence ID" value="AAS11993"/>
        <property type="gene ID" value="TDE_1476"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1476"/>
    <dbReference type="HOGENOM" id="CLU_2902977_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="62" mass="7285" checksum="9F2C42E933F97C64" modified="2004-07-05" version="1">MLKNTPVFYNCIKFCAFYTNYKDSIINNFIQTANNTVNTGLHKGRPSRAFFQRSFKRQGKFP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-06-16" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MR1</accession>
    <name>MIAA2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA dimethylallyltransferase 2</fullName>
            <ecNumber evidence="1">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dimethylallyl diphosphate:tRNA dimethylallyltransferase 2</fullName>
            <shortName evidence="1">DMAPP:tRNA dimethylallyltransferase 2</shortName>
            <shortName evidence="1">DMATase 2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopentenyl-diphosphate:tRNA isopentenyltransferase 2</fullName>
            <shortName evidence="1">IPP transferase 2</shortName>
            <shortName evidence="1">IPPT 2</shortName>
            <shortName evidence="1">IPTase 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaA2</name>
        <name type="ordered locus">TDE_1447</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972053.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679096.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MR1"/>
    <dbReference type="SMR" id="Q73MR1"/>
    <dbReference type="STRING" id="243275.TDE_1447"/>
    <dbReference type="EnsemblBacteria" id="AAS11964">
        <property type="protein sequence ID" value="AAS11964"/>
        <property type="gene ID" value="TDE_1447"/>
    </dbReference>
    <dbReference type="GeneID" id="2741410"/>
    <dbReference type="KEGG" id="tde:TDE_1447"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1388"/>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_0_1_12"/>
    <dbReference type="OMA" id="LEIAIHQ"/>
    <dbReference type="OrthoDB" id="1069591at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000377360" description="tRNA dimethylallyltransferase 2">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <begin position="44"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <sequence length="298" mass="34646" checksum="F225DB00FC27C622" modified="2004-07-05" version="1">MNLDFLSLSDKHNSVVVLGATATGKTSYAVGLAKELGGEIISADSRQVYKGLDLGTGKDLKEYGDVPHHLIDICTLEREYNVFDFQNDAYKAFEDIKRRKKLPIFAGGTGLYLDSLIREYELIPVPKNEELRASLAGKDLTELQKFFFEYNVPMHNKTDLENMDRLMRAIEIAEYKKTHPDAAEILNANRPDIRPLIIGLKYPREILRERIRLRLLERIKDGMIEETESLHKEGFSWERLESLGLEYKFTAQYLQGKIKSREEYVDSLYRAICQFAKRQETWFRRMEKNGVKINWVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MV4</accession>
    <name>Q73MV4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1403</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS11920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1403"/>
    <dbReference type="EnsemblBacteria" id="AAS11920">
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    <dbReference type="eggNOG" id="COG0488">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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    <dbReference type="InterPro" id="IPR003439">
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    </dbReference>
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    </dbReference>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS11920.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="667" mass="74845" checksum="2F0C2B97E976EA77" modified="2004-07-05" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
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                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
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                <person name="Weinstock G.M."/>
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            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="183" mass="20940" checksum="F80EE0F7CE31CD6D" modified="2004-07-05" version="1">MASYYYLTAQLPSIFPNLQPPMSFKAFKELALRSLSKKDAQILENLTLEPPREEKSTGSAYLDKWYEFERSLRIALEQVRSAKLKWEAPISYDERVLLSSAFTPVQIARTAASIQNPLEAETFLDNARFQAADTVRGAENFSSDGIFAYAVKLLLRERASKFEMEKGKEEYSSIYNTILDEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MZ1</accession>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11882.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
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    <sequence length="192" mass="22687" checksum="E04C4A306D8F2372" modified="2004-07-05" version="1">MDKKEELLASAHAIFTKKGYKETNISDITKSINVATGSFYKYYSSKEDIFLEVYKLENTRVRQLVMEHVDWQLPIESIIESLFFVTSKHLFGNKIMAEWSNPKISKILRKYYFSEQGKKDNQFHNFLMTVIDKKMKELKIKPQLAVRLKRVYEFLYYIDCHVTDSDFEGCSEVIKLLTVYFVKGLVYENSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N42</accession>
    <name>Q73N42_TREDE</name>
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        <submittedName>
            <fullName evidence="4">Penicillin-binding protein</fullName>
        </submittedName>
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971920.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678847.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1314"/>
    <dbReference type="EnsemblBacteria" id="AAS11831">
        <property type="protein sequence ID" value="AAS11831"/>
        <property type="gene ID" value="TDE_1314"/>
    </dbReference>
    <dbReference type="GeneID" id="2739572"/>
    <dbReference type="KEGG" id="tde:TDE_1314"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1263"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_6_0_12"/>
    <dbReference type="OMA" id="HGKEEYY"/>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="3">
        <location>
            <begin position="559"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="620" mass="68378" checksum="2F7F6BE98EB48635" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NA4</accession>
    <name>Q73NA4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BatB protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971858.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678757.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1251"/>
    <dbReference type="EnsemblBacteria" id="AAS11769">
        <property type="protein sequence ID" value="AAS11769"/>
        <property type="gene ID" value="TDE_1251"/>
    </dbReference>
    <dbReference type="GeneID" id="2741427"/>
    <dbReference type="KEGG" id="tde:TDE_1251"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1203"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024570_1_0_12"/>
    <dbReference type="OMA" id="QFQWFLG"/>
    <dbReference type="OrthoDB" id="743737at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="83"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="322" mass="35282" checksum="41B45DE1BB7EA810" modified="2004-07-05" version="1">MISFENSVYLFFILFLFPCWFIFYINLKKIKKAYSGLENTKKIIKKAKIRALFFSAAWIFLILGLACPLWGSKPVSVRRRGVSVIFVSDISKSMSLQDIHPSRIAVQRQFLKILLEKMHKTSPESAVGLVITKGEGVLSVPLSFEKNALSSAINALSPLILSSTGTNLEAGVLRALDSFGENRGNSKIIVLCTDGGETSGSLLHAAEKIKKTDAILIIVGFGTLEETKIKVLDEKGNTQLKDARLEEAFLQKAASIAGGESTYISALSSGSIESILKIIDAGVEGVEKMVYIQEPVKRNFEMLLLAFIFLCLGGVSFYGKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NC9</accession>
    <name>Q73NC9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc ABC transporter, periplasmic zinc-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">troA</name>
        <name evidence="5" type="ordered locus">TDE_1226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971833.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671643.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1226"/>
    <dbReference type="EnsemblBacteria" id="AAS11744">
        <property type="protein sequence ID" value="AAS11744"/>
        <property type="gene ID" value="TDE_1226"/>
    </dbReference>
    <dbReference type="GeneID" id="2741168"/>
    <dbReference type="KEGG" id="tde:TDE_1226"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1181"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_1_1_12"/>
    <dbReference type="OMA" id="DPHIWFD"/>
    <dbReference type="OrthoDB" id="1703187at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284616" evidence="4">
        <location>
            <begin position="29"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="312" mass="34583" checksum="ACF768003183E0A5" modified="2004-07-05" version="1">MTKKLIVLCLTGLTILSSVFFSCSKTEATNEAKDSGKIKITATIGMVADIAKVVGGDEVNVQALMGAGVDPHLYRASAGDMEKLQKADIIFYSGLHLEAKMGEVLQKISSTRKTVAVAESIPKEYLLPFEESEFDPHVWFDVKLWKYATESVYKTLAEFAPQKKEVFKENYEFYLARLNELDEFIKKRASEIPQEKRVLVTAHDAFNYFSKAYGFEVRGLQGISTVSEAGAKDVQELADFITKRKLPAIFVESSVPEKNVKALQEAVKARGYDVSIGGELFSDAMGDEGSFEGTYIGMLTHNINTIIDALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NH0</accession>
    <name>Q73NH0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971790.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1182"/>
    <dbReference type="EnsemblBacteria" id="AAS11701">
        <property type="protein sequence ID" value="AAS11701"/>
        <property type="gene ID" value="TDE_1182"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1182"/>
    <dbReference type="HOGENOM" id="CLU_3190263_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="46" mass="5278" checksum="E87B427724B0C718" modified="2004-07-05" version="1">MIITAAFFSCLIGRFNIDFKDIYAICIGDKRIETIDLKRHILFKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NN9</accession>
    <name>Q73NN9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971721.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670668.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1113"/>
    <dbReference type="EnsemblBacteria" id="AAS11602">
        <property type="protein sequence ID" value="AAS11602"/>
        <property type="gene ID" value="TDE_1113"/>
    </dbReference>
    <dbReference type="GeneID" id="2739529"/>
    <dbReference type="KEGG" id="tde:TDE_1113"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1073"/>
    <dbReference type="eggNOG" id="ENOG502ZBZ8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1538633_0_0_12"/>
    <dbReference type="OMA" id="LECELYN"/>
    <dbReference type="OrthoDB" id="1223384at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="173" mass="20183" checksum="289F8C873B8B3C83" modified="2004-07-05" version="1">MITLHEQVDISAPFEKLCAWADNFEEEFVKWSPYHLECELYNGNVNTGSKVRFYEIVMGLDYDVTGTIVTSERDNDHFRFVFKSDKGTAFITFEGTRTKDGCRFSHTESFGITTPVIGPIMNFLLFKIIFRKKCNWQLIRDDMILDNKYLTEILTEGKYPERIPVERLKAGIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NP0</accession>
    <name>KAD_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylate kinase</fullName>
            <shortName evidence="1">AK</shortName>
            <ecNumber evidence="1">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">adk</name>
        <name type="ordered locus">TDE_1112</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971720.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670667.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NP0"/>
    <dbReference type="SMR" id="Q73NP0"/>
    <dbReference type="STRING" id="243275.TDE_1112"/>
    <dbReference type="EnsemblBacteria" id="AAS11601">
        <property type="protein sequence ID" value="AAS11601"/>
        <property type="gene ID" value="TDE_1112"/>
    </dbReference>
    <dbReference type="GeneID" id="2739528"/>
    <dbReference type="KEGG" id="tde:TDE_1112"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1072"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_1_12"/>
    <dbReference type="OMA" id="FHNRMRV"/>
    <dbReference type="OrthoDB" id="1491686at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000158877" description="Adenylate kinase">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="1">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <sequence length="209" mass="23178" checksum="49CEF340B6665611" modified="2004-07-05" version="1">MNCIFLGPPGAGKGTLAFEVSKSYKIPHISTGDLFRAAIKEQTDLGKKVKAVIDSGALVSDDLTIALVKERLERDDTKKGFILDGFPRTIAQADALEDIVKIDSVINFDISDDEVIKRLSGRRVCSSCGQSFHIEFVKPKKEGICDSCSGDLMIRPDDKIEAIQKRLETYRNQTAPLIDYYTKKDLIVNIDARPASEKVLASFKVKFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NQ4</accession>
    <name>Q73NQ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971706.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682408.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1098"/>
    <dbReference type="EnsemblBacteria" id="AAS11587">
        <property type="protein sequence ID" value="AAS11587"/>
        <property type="gene ID" value="TDE_1098"/>
    </dbReference>
    <dbReference type="GeneID" id="2740228"/>
    <dbReference type="KEGG" id="tde:TDE_1098"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1057"/>
    <dbReference type="eggNOG" id="ENOG5031GND">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_921148_0_0_12"/>
    <dbReference type="OrthoDB" id="1795258at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="302" mass="35152" checksum="C1C3886BB698AD09" modified="2004-07-05" version="1">MKKNIKPDTIKDLLNSHLKNDNFKTLEPIQLEDHTYTDLFKGITGGNETFAVKLRQKTESIKNSIKYLNALNDSEDFILKYKNLIETEDYYIFISEWLEGCQPTKTDRYLIKDFFKKLAHLNLNNTSSSSFSSMYLDGKSYPSIEEMINAEALPYLEIYRGKHDKKIIKKNIENLNLGLGCIIIEDMNTGNMLKTEKGSLKIIDAEHITSGLNLYQFEHINILGLNKKEWHNITDEAKEVLNAYFSEIGESKNKAFLQIKAFAVLSFLRELYFQVWQKQKIDYSEKDRIFDIILNCVVEEVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NR2</accession>
    <name>SYT_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="1">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thrS</name>
        <name type="ordered locus">TDE_1090</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971698.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682400.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NR2"/>
    <dbReference type="SMR" id="Q73NR2"/>
    <dbReference type="STRING" id="243275.TDE_1090"/>
    <dbReference type="EnsemblBacteria" id="AAS11579">
        <property type="protein sequence ID" value="AAS11579"/>
        <property type="gene ID" value="TDE_1090"/>
    </dbReference>
    <dbReference type="GeneID" id="2739102"/>
    <dbReference type="KEGG" id="tde:TDE_1090"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1049"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_12"/>
    <dbReference type="OMA" id="FYYDFAY"/>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000101077" description="Threonine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="1">
        <location>
            <begin position="185"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <sequence length="585" mass="66904" checksum="D20BC356978D5B75" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NR5</accession>
    <name>Q73NR5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytidylate kinase</fullName>
            <shortName evidence="5">CK</shortName>
            <ecNumber evidence="5">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytidine monophosphate kinase</fullName>
            <shortName evidence="5">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">cmk</name>
        <name evidence="6" type="ordered locus">TDE_1087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytidylate kinase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971695.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682399.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1087"/>
    <dbReference type="EnsemblBacteria" id="AAS11576">
        <property type="protein sequence ID" value="AAS11576"/>
        <property type="gene ID" value="TDE_1087"/>
    </dbReference>
    <dbReference type="GeneID" id="2739099"/>
    <dbReference type="KEGG" id="tde:TDE_1087"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1046"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079959_1_0_12"/>
    <dbReference type="OMA" id="FIFRDMA"/>
    <dbReference type="OrthoDB" id="1392851at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00239">
        <property type="entry name" value="Cytidyl_kinase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011892">
        <property type="entry name" value="Cyt_kin_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02173">
        <property type="entry name" value="cyt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="20"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="187" mass="21278" checksum="A40B7905DA73F7C9" modified="2004-07-05" version="1">MKKTAFKIPEGKELRIAISGPSGCGNTTVSTLTAKTLNLPCINYTFKNIAKELNISFEEVLRRAQEDFSFDKTVDKKQIELAEASSCVLGSRLAIWLLNQADLRVYLRASIEVRAKRIQKREGGDIEKIKADTDLRDMEDTRRYKELYGIDNTKYEKADLIIDTDNLTPEKIVKKILSELYSRGLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NV1</accession>
    <name>Q73NV1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971659.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670543.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11540">
        <property type="protein sequence ID" value="AAS11540"/>
        <property type="gene ID" value="TDE_1051"/>
    </dbReference>
    <dbReference type="GeneID" id="2741325"/>
    <dbReference type="KEGG" id="tde:TDE_1051"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1011"/>
    <dbReference type="eggNOG" id="ENOG502ZIX0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180098_1_0_12"/>
    <dbReference type="OMA" id="DFIFTIG"/>
    <dbReference type="OrthoDB" id="1750308at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="94" mass="10703" checksum="983A9A8960D3EFB7" modified="2004-07-05" version="1">MEIKDFINTIGYDGNSAIVDKARLSKNSNKNLDQLLESGAFRAAAAYAVYTESEEDLQKVADEYNKISHSNYKKEQIKRLFGVSKVEVKKKLVW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NX7</accession>
    <name>RL32_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmF</name>
        <name type="ordered locus">TDE_1025</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971633.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670496.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NX7"/>
    <dbReference type="SMR" id="Q73NX7"/>
    <dbReference type="STRING" id="243275.TDE_1025"/>
    <dbReference type="EnsemblBacteria" id="AAS11514">
        <property type="protein sequence ID" value="AAS11514"/>
        <property type="gene ID" value="TDE_1025"/>
    </dbReference>
    <dbReference type="GeneID" id="2740965"/>
    <dbReference type="KEGG" id="tde:TDE_1025"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.987"/>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129084_1_0_12"/>
    <dbReference type="OMA" id="HRACRHC"/>
    <dbReference type="OrthoDB" id="2092354at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000172428" description="50S ribosomal protein L32">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <sequence length="62" mass="6935" checksum="596AA1C4CEFB5756" modified="2004-07-05" version="1">MAVPRANTSKARTRRRRGVNMRLQAPNLVECSGCGNLIMPHHVCPKCGFYKGKQVINPDKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P01</accession>
    <name>Q73P01_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FNT transporter (TC 2.A.44) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971608.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670448.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0999"/>
    <dbReference type="EnsemblBacteria" id="AAS11489">
        <property type="protein sequence ID" value="AAS11489"/>
        <property type="gene ID" value="TDE_0999"/>
    </dbReference>
    <dbReference type="GeneID" id="2739076"/>
    <dbReference type="KEGG" id="tde:TDE_0999"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.959"/>
    <dbReference type="eggNOG" id="COG2116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036896_3_0_12"/>
    <dbReference type="OMA" id="MIWFPIM"/>
    <dbReference type="OrthoDB" id="1834167at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="PTHR30520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00790">
        <property type="entry name" value="fnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01005">
        <property type="entry name" value="FORMATE_NITRITE_TP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01006">
        <property type="entry name" value="FORMATE_NITRITE_TP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="278" mass="29835" checksum="1AC4AC65BEAA1343" modified="2004-07-05" version="1">MSEKMYCDPAEILEVTVQKGIAKASTSVWKLLCLGFLAGVFIAFASEGSNMAAFGLFAKPETYGLGKFVAGLIFPVGLILVLLAGAELFTGNNLIIAAVLEKKVSFSAMLKNWIAVYIGNLIGSVFIAFLIVQSGQLSSGANLLGGITIKIAYGKVSLSFVQAVFLGIMCNWLVCLAVWLCYGAKDMTGKMLAAFFPIWLFITSGFEHSVANMYYIPAGIFSKSVPAYAAASGLSAEALSNINWAAFFIKNLMPVTLGNIIGGAFFVGMFYWICYKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P26</accession>
    <name>Q73P26_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">radC</name>
        <name evidence="8" type="ordered locus">TDE_0973</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0758 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971583.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682286.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0973"/>
    <dbReference type="EnsemblBacteria" id="AAS11464">
        <property type="protein sequence ID" value="AAS11464"/>
        <property type="gene ID" value="TDE_0973"/>
    </dbReference>
    <dbReference type="GeneID" id="2740545"/>
    <dbReference type="KEGG" id="tde:TDE_0973"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.937"/>
    <dbReference type="eggNOG" id="COG2003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073529_0_2_12"/>
    <dbReference type="OMA" id="AMPDYEL"/>
    <dbReference type="OrthoDB" id="1833204at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="100"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="225" mass="25361" checksum="11C0D7564E109135" modified="2004-07-05" version="1">MIDYKNSSNTDKPDMRERLLEYGPQNLSDSDLVAILLRTGIKDKPVKELADDIILHIDRARPEKIEGYLRSIRGMGDSKISTVLAAMELGRRYYDNKNRTISHPTDVVPLLQHYADRDREHFICVSLNGANEIIATRVVSVGTINRTIVHPREVYSDPLKDRAAAIIAAHNHPSGNLEPSSEDMELTKRIYEAGKILGIKLLDHIILVPNGNFFSFVQSGTRFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P56</accession>
    <name>Q73P56_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971553.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0943"/>
    <dbReference type="EnsemblBacteria" id="AAS11434">
        <property type="protein sequence ID" value="AAS11434"/>
        <property type="gene ID" value="TDE_0943"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0943"/>
    <dbReference type="HOGENOM" id="CLU_2774744_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="69" mass="8347" checksum="7E67EA12EF0CF25C" modified="2004-07-05" version="1">MIWKRIAGSYKHSHKKITKSFEKALDIKYRIRAVVRFYAFFILHRKARKALSFAQLRRGLLRMSLQRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PA6</accession>
    <name>Q73PA6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0893</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971503.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682173.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0893"/>
    <dbReference type="EnsemblBacteria" id="AAS11384">
        <property type="protein sequence ID" value="AAS11384"/>
        <property type="gene ID" value="TDE_0893"/>
    </dbReference>
    <dbReference type="GeneID" id="2739767"/>
    <dbReference type="KEGG" id="tde:TDE_0893"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.863"/>
    <dbReference type="eggNOG" id="COG4586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="LIWDIPP"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="32"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="65"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="343" mass="39222" checksum="992261800064AD6C" modified="2004-07-05" version="1">MSDRAVSNEKIIVAENICKSYAYYQKDAGLKGSIKNLFKRKKLYKPAVKNLSFEIAQGSITGLIGLNGAGKTTTLKMLSGLILPTEGSLTVLQHNPFEKKKEYLRQISMVMGNKSQLWWDLPAVDSFELNKTIYEVEDADYKKTLHTMIEILGVQKQVNVQVRRLSLGERMKMELIAALIHKPKLIFLDEPTIGLDIITQYNIRDFLKHYCNKYHASLILTSHNFNDIVSLCTELILINKGEKIYSDSFINFKNEFLNKKYFILKLKLLKADKIIKTLQEKGNFFAEKTAKDTVKISADSTKSLDILKNISNDFIEELSDITIENISMEDVIRRLYTSSESIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PJ9</accession>
    <name>Q73PJ9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971410.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682055.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0800"/>
    <dbReference type="EnsemblBacteria" id="AAS11291">
        <property type="protein sequence ID" value="AAS11291"/>
        <property type="gene ID" value="TDE_0800"/>
    </dbReference>
    <dbReference type="GeneID" id="2740678"/>
    <dbReference type="KEGG" id="tde:TDE_0800"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.773"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1730600_0_0_12"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="144" mass="17067" checksum="BE7CCA93214191D4" modified="2004-07-05" version="1">MPDWIKYRIPKKLLDNKNKNIKIEEFSESEHKDIIPQIYADAFCDKAWESDWYKIDLFNPASCFIAKYNEEYAGFIISFIKENSAYISVIAVLKKYQKCGIGISLINRVINYFKNQDLEIYLDVESKNKTAINWYNKRGFIQII</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PL1</accession>
    <name>RL36_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmJ</name>
        <name type="ordered locus">TDE_0788</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971398.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672206.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PL1"/>
    <dbReference type="SMR" id="Q73PL1"/>
    <dbReference type="STRING" id="243275.TDE_0788"/>
    <dbReference type="EnsemblBacteria" id="AAS11279">
        <property type="protein sequence ID" value="AAS11279"/>
        <property type="gene ID" value="TDE_0788"/>
    </dbReference>
    <dbReference type="GeneID" id="2740666"/>
    <dbReference type="KEGG" id="tde:TDE_0788"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.761"/>
    <dbReference type="eggNOG" id="COG0257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_6_2_12"/>
    <dbReference type="OrthoDB" id="2066169at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000126287" description="50S ribosomal protein L36">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <sequence length="37" mass="4277" checksum="AF2767A3DE04EFF5" modified="2004-07-05" version="1">MKVRTSVKPICDKCKVIKRNGIVRIICTNPKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PL2</accession>
    <name>Q73PL2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">secY</name>
        <name evidence="3" type="ordered locus">TDE_0787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971397.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670031.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0787"/>
    <dbReference type="EnsemblBacteria" id="AAS11278">
        <property type="protein sequence ID" value="AAS11278"/>
        <property type="gene ID" value="TDE_0787"/>
    </dbReference>
    <dbReference type="GeneID" id="2740665"/>
    <dbReference type="KEGG" id="tde:TDE_0787"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.760"/>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030313_0_2_12"/>
    <dbReference type="OMA" id="FAMWLGE"/>
    <dbReference type="OrthoDB" id="1567535at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="438" mass="48697" checksum="321AAC0DE30BA3AA" modified="2004-07-05" version="1">MANNVFANMFKIKDLRSRIFFTIIVLAVFRLGSVLTIPGIDPGALTIYFRQGQGNAFADHMDFFVGGAFSNFSVFMLGVMPYISTQILMQLAMIIFPRLKKIAEEDGGRKKIQVWTRIVTVFVALLQSSAVGTWARAIPGAVVISSPVLHLFITMVTVTTGTMITVWMGEQITARGIGNGISMLIFAGIVARLPQAVWELIKLVSNNELNLVFVIIAFAMFVGIIALVVYEQQGQRKIPVHYAKRVIGRKMYGGQNTYIPFKINPSGVIPIIFASSFLTFPLMLSQMWGSNVSWLASVARFLRSDGWGYNVLYVVLIIFFAYFYTQVALNPTEIAKQIRENGGSIPGIRTDKTEEYLQKILNRLILPGSLYLAAIAVLPTVIQWAFSFPRNISMLMGGTSLLILVGVDLDTMSQVEALLKMHHHDGLLKKGKIRSRNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PN3</accession>
    <name>EFTU_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor Tu</fullName>
            <shortName evidence="2">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tuf</name>
        <name type="ordered locus">TDE_0765</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971375.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669993.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PN3"/>
    <dbReference type="SMR" id="Q73PN3"/>
    <dbReference type="STRING" id="243275.TDE_0765"/>
    <dbReference type="PRIDE" id="Q73PN3"/>
    <dbReference type="EnsemblBacteria" id="AAS11256">
        <property type="protein sequence ID" value="AAS11256"/>
        <property type="gene ID" value="TDE_0765"/>
    </dbReference>
    <dbReference type="GeneID" id="2740305"/>
    <dbReference type="KEGG" id="tde:TDE_0765"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.738"/>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_1_12"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000015780" description="Elongation factor Tu">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <sequence length="395" mass="43788" checksum="2BEFAD3269BE3077" modified="2004-07-05" version="1">MAKEKFNRTKVHMNVGTIGHVDHGKTTLSAAITTYCAKKYGDKLLKYDEIDNAPEEKERGITINTRHLEYQSDKRHYAHIDCPGHADYVKNMITGAAQMDGAILVVSAPDSVMPQTKEHLLLARQVGVPSIIVFLNKVDLVDDPELVELVEEEVRETLTSYGFPEDTPIIKGSAFKALQEGATAEDTACIEELLKTMDEYFKDPVRDSDKPFLLPIEDIFTIQGRGTVVTGRIERGVIKMNEEVEIVGIKPTKKTVVTGIEMFNKLLDEGEAGDNVGLLLRGIEKKEVERGQVLAKPGSIHPHTKFEAQIYVLSKEEGGRHSPFFSGYRPQFYFRTTDITGTVNLPEGTDMVKPGDNTKIIGELIHPIAMDQGLKLAIREGGRTIASGQVTNIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PQ1</accession>
    <name>Q73PQ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron compound ABC transporter, ATP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971357.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682004.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0746"/>
    <dbReference type="EnsemblBacteria" id="AAS11238">
        <property type="protein sequence ID" value="AAS11238"/>
        <property type="gene ID" value="TDE_0746"/>
    </dbReference>
    <dbReference type="GeneID" id="2740300"/>
    <dbReference type="KEGG" id="tde:TDE_0746"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.721"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_0_0_12"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="392" mass="44132" checksum="350C6104F08A0183" modified="2004-07-05" version="1">MDLFKLKQLDVGYGNSVIVGNVEIELQHGQILCLMGPNGSGKSTIIKTITQHIKKLGGKVFIGEEDIEKLSNIEQAKKMSVVLTDRINPHLMTAEEIVATGRYPHTNKFGKMTEADYIAVDDAIKIVDGEVLKHKEFLSLSDGEKQRIMIARAICQEADLIILDEPTSFLDIRYKIDLLGILRTLARKKNKIIILSLHELDLIPKIADKIILILDKDNYLYGTPEEIISDTSIRKAFDIKNGSYNTLLGNIELARRDTSSKIFVVGGEGKGIPVYRLLNKYEINFNSGILFENDLDTPIAKALSTNHLTQNSFETINDKIFDEAKLVIEKSEIIIDCGASFNGINSRNLDLIKYAEELNKKILSLKERQEYADYTYCNTFSQLLKTIKCLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PU3</accession>
    <name>Q73PU3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971315.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672276.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0703"/>
    <dbReference type="EnsemblBacteria" id="AAS11196">
        <property type="protein sequence ID" value="AAS11196"/>
        <property type="gene ID" value="TDE_0703"/>
    </dbReference>
    <dbReference type="GeneID" id="2739825"/>
    <dbReference type="KEGG" id="tde:TDE_0703"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.681"/>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_4_3_12"/>
    <dbReference type="OMA" id="YAWTVKV"/>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="74" mass="8136" checksum="CCF74930C428DDDE" modified="2004-07-05" version="1">MGYPKGKYAWTVKVGEKGQFVIPKEARDVFNINPGDTLIVLGDINQGIAIPPKNMFTSIIDNIFGGNVPKEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PU5</accession>
    <name>Q73PU5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_0701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971313.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0701"/>
    <dbReference type="EnsemblBacteria" id="AAS11194">
        <property type="protein sequence ID" value="AAS11194"/>
        <property type="gene ID" value="TDE_0701"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0701"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.679"/>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099748_0_0_12"/>
    <dbReference type="OMA" id="NPIYHMN"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="3"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="242" mass="26137" checksum="F73A5BC516F541FC" modified="2004-07-05" version="1">MRILLFARRNTKEVLRDPINFFFGLGFPIILLILLSIINAAIPPEAENPMFEIRNLAPGLAMFGSVFMALFSGMLLSKDRTSSFLMRLFTSPMTSVDFILGYTLPMLAMTIVQAAITLLAAGAFGLEITIHFLFAVIVTALTSLLFVGTGLLFGSLMNDKAVGGVCGALLTNVAGWLSGVFIPIDLIGGAFKKITNILPFYHSVEAIKSTLSGNFGHALSHLTVVMSYTIVIFVLAIYCLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PU6</accession>
    <name>Q73PU6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971312.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681921.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0700"/>
    <dbReference type="EnsemblBacteria" id="AAS11193">
        <property type="protein sequence ID" value="AAS11193"/>
        <property type="gene ID" value="TDE_0700"/>
    </dbReference>
    <dbReference type="GeneID" id="2739822"/>
    <dbReference type="KEGG" id="tde:TDE_0700"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.678"/>
    <dbReference type="eggNOG" id="ENOG502ZR36">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_780619_0_0_12"/>
    <dbReference type="OrthoDB" id="2061588at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="355" mass="40386" checksum="C3EEDFECB94DA885" modified="2004-07-05" version="1">MFNLKKACFIIFTLIFISSCSKQNREFTGKYLTYTNTEEGYEIDYPSEILRPIDSSPAEQVFTSNDGEVTLSVSVSDLKDSGPEFIFKTADLYEKKEAEKFTVSDKNMGRDGFILKGYSKDKMFFCQALAINEKFYTIRFEYNKKEYDTYRDILTHIIDSFELTSASVSQEGSEDEKSYDEGTLISFAFSFLSNVYWENNFNLLLKNSSPKLADFVHPDYGIRRFYNPGAAPLLFSAEDGFGFDESADFSTKPSANKFGGSIPFYNRMPDGGFCEESNDKDGVYCAIVKEIPTAVDPASFEGDEIKNLKINLPRNYKAILKIVVLDGGFIKKTFYFFDIADNWFLLFVDDCDCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q08</accession>
    <name>Q73Q08_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971250.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681827.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0636"/>
    <dbReference type="EnsemblBacteria" id="AAS11131">
        <property type="protein sequence ID" value="AAS11131"/>
        <property type="gene ID" value="TDE_0636"/>
    </dbReference>
    <dbReference type="GeneID" id="2739361"/>
    <dbReference type="KEGG" id="tde:TDE_0636"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.614"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_12"/>
    <dbReference type="OMA" id="MSSLNPC"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="322" mass="35967" checksum="BBBF62EDEC36056E" modified="2004-07-05" version="1">MADTLLEVYNLKKYFTLGRKEILHAVDDVSFTINRGETVGIVGESGCGKTTLGRTVLGLYRPTAGKIIFDGAEIGSASKKELHTFKKRAQIILQDPFASFNPRMTISQIISEGMEAHNLYKTKKERENSVYSLLETVGLVPEHANRFPHEFSGGQRQRIGIARALAVEPDFIVCDEPISSLDVSIQAQIINLLIRLQKEFKMTYLFIAHDLSIVKYISDKVGVMYSGKLVEFAKSADLYKNPLHPYSQALISAIPSTDIDSPMSARRIHIHGEISSAINPPQGCRFYKRCPKAFEKCKSIPPELIETEEGHFTACHLINPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QE2</accession>
    <name>Q73QE2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971115.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681624.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0501"/>
    <dbReference type="EnsemblBacteria" id="AAS10996">
        <property type="protein sequence ID" value="AAS10996"/>
        <property type="gene ID" value="TDE_0501"/>
    </dbReference>
    <dbReference type="GeneID" id="2738986"/>
    <dbReference type="KEGG" id="tde:TDE_0501"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.487"/>
    <dbReference type="eggNOG" id="ENOG502Z7K1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063412_0_0_12"/>
    <dbReference type="OrthoDB" id="795679at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="375" mass="44026" checksum="7756AA602CA9C10C" modified="2004-07-05" version="1">MNIFKPIVILLCIVCSVIFLNACSHIKEDSEMIIKYLDNRFGKDAYTIKKDKYYRRWLVTLNEYPDLIIFYTVSRDPLSMTSPSIKTNFDEIFGEYIIEEYKKNYELGNDEIFWEIPINFIYYTKVHSLEELKVPYDRAMEFIAFVSEKHPMLIDERLLNIRMDIDGIKLKGAADDDSMIYQDISEVKKDGLNIKSYEAICKELKPQLKTHSDNPNGFTFHADIGRSFILGSDTFEDCFFKNLIIKQGTIEELKNIILQPGEISKAYVFKSDNQYEFTNITLQAKNLSDSPCSLLEATIIKAIIDDAKEIYIEPVWIDLVFDKRREWKEPYEILGVSPPKTEQENMEGVQYKNIKILFEMNQYYKEVKRITLTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QI2</accession>
    <name>Q73QI2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971075.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10956">
        <property type="protein sequence ID" value="AAS10956"/>
        <property type="gene ID" value="TDE_0461"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0461"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.447"/>
    <dbReference type="HOGENOM" id="CLU_2940466_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="60" mass="7178" checksum="28B1A6DF881BC85A" modified="2004-07-05" version="1">MMKKSFNFLHMPSLFLRLPVKVYLKDFFLSIFLSLTFELRNIRFYKKKAARKGGERAACE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QJ5</accession>
    <name>DEOC_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="1">DERA</shortName>
            <ecNumber evidence="1">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="1">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">deoC</name>
        <name type="ordered locus">TDE_0448</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971062.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672661.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73QJ5"/>
    <dbReference type="SMR" id="Q73QJ5"/>
    <dbReference type="STRING" id="243275.TDE_0448"/>
    <dbReference type="EnsemblBacteria" id="AAS10943">
        <property type="protein sequence ID" value="AAS10943"/>
        <property type="gene ID" value="TDE_0448"/>
    </dbReference>
    <dbReference type="GeneID" id="2740430"/>
    <dbReference type="KEGG" id="tde:TDE_0448"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.435"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_1_12"/>
    <dbReference type="OMA" id="KRGIGNE"/>
    <dbReference type="OrthoDB" id="1227369at2"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_0000231573" description="Deoxyribose-phosphate aldolase">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <sequence length="216" mass="23447" checksum="5B1A92CE8A0F42BF" modified="2004-07-05" version="1">MELNKYIDHTLLKPTASEKDIIKICNEAKEYHFASVCVNPCNVSLVRKELKGSDVKVCSVISFPFGASSTEVKVEEAKKAIEAGAEEIDMVINVGKLLEGDLEYTQNEVSAITKACHEKNVLLKVIVETCYLEEKNIADICAIIEKAGADFIKTSTGYGSRGASVEDIKLFKKYLKKDTKIKASGGVRTREDAETYIGLGCSRIGASSGIAIVTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QM9</accession>
    <name>Q73QM9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971028.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0414"/>
    <dbReference type="EnsemblBacteria" id="AAS10909">
        <property type="protein sequence ID" value="AAS10909"/>
        <property type="gene ID" value="TDE_0414"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0414"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.401"/>
    <dbReference type="HOGENOM" id="CLU_2304791_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="100" mass="11708" checksum="35C51DC75A3EBE3B" modified="2004-07-05" version="1">MHLKPKKKSDWVACCGNKIVLLDVYTDEEDSYILMQYFKRKYPLISADDPFYYCCGTMMGPYIFILRRLEGYGSDRDEKDYLFSLNLVNAGIFNYGGSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QN1</accession>
    <name>Q73QN1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971026.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0412"/>
    <dbReference type="EnsemblBacteria" id="AAS10907">
        <property type="protein sequence ID" value="AAS10907"/>
        <property type="gene ID" value="TDE_0412"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0412"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.399"/>
    <dbReference type="HOGENOM" id="CLU_049884_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010103">
        <property type="entry name" value="Clustered_lipoprot_TREDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09710">
        <property type="entry name" value="Trep_dent_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01781">
        <property type="entry name" value="Trep_dent_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="463" mass="54636" checksum="FBB61D62A3F64CD0" modified="2004-07-05" version="1">MQKNVKPLFPKNLKASGWAFGRPIQNNFLNYETLNMENSLMQKDKLKLIFILMLAVLLFSCTKEIKEPAEERNSVVKNEVMEKKPLLILEHTIPSKEEDDEDIDFTEEEPPIVLTDENTPKTELIKLLESKKRHAWSLHKIQLEIDMYDVHGNSYEEFEKSGIDYLNRQKNTEIVKVDSDNKNIYCKQTLNLPSGKELIYDAVYTFYPYPKNFAYTNYELRDKPIIAYRHVPEAKRVHGKITEAAKNPNKNKNIKIFERYINKYTKEHRHKTGDKPYKVFDYVKGNFTGSGKDEYIVLFTAPFTKSELEDGIFLLEYSYIKYVECFIMENDKVIKMYKLPGHWGHVVPRDKTKIDLGEQFSFGWIADFNQNGINEIFVHRKEVFGSSFFSIEFIDNRFVEIPITNRGDILKSVDWEQSKIVVETNPFRSLVLDSKDTRPKYFAEYQWCEKEHCYVLLSNKQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QS0</accession>
    <name>Q73QS0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970987.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681389.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0373"/>
    <dbReference type="EnsemblBacteria" id="AAS10868">
        <property type="protein sequence ID" value="AAS10868"/>
        <property type="gene ID" value="TDE_0373"/>
    </dbReference>
    <dbReference type="GeneID" id="2740125"/>
    <dbReference type="KEGG" id="tde:TDE_0373"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.363"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_521691_0_0_12"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="4"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="313"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="350"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="523" mass="60331" checksum="1FC1E63DA4DABFD7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QW9</accession>
    <name>Q73QW9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970938.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666308.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10819">
        <property type="protein sequence ID" value="AAS10819"/>
        <property type="gene ID" value="TDE_0324"/>
    </dbReference>
    <dbReference type="GeneID" id="2739331"/>
    <dbReference type="KEGG" id="tde:TDE_0324"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.313"/>
    <dbReference type="eggNOG" id="ENOG50301R3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1314914_0_0_12"/>
    <dbReference type="OrthoDB" id="1843610at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="206" mass="23010" checksum="118EAB4C201434D2" modified="2004-07-05" version="1">MQKLLKKFYLLTVLILTVCLAASCTMLSGFKKLSETGHASINGKKVNLKTMGDPEKDCLAFGYLKIPTEQLYIQSDPSKEPIYTTPFVFPGAYSDGSIFCFPPFKTDLAFQLASLRNVNFNVITTFSPQLGAEGKIAFVTHKKGLMFIGAYDFVTEGKAGMIVPLARKDSAQYELKCLLKIKKLLQHTAWLPLIEARIKELENEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QY6</accession>
    <name>Q73QY6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970921.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681254.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0307"/>
    <dbReference type="EnsemblBacteria" id="AAS10802">
        <property type="protein sequence ID" value="AAS10802"/>
        <property type="gene ID" value="TDE_0307"/>
    </dbReference>
    <dbReference type="GeneID" id="2741028"/>
    <dbReference type="KEGG" id="tde:TDE_0307"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.296"/>
    <dbReference type="eggNOG" id="ENOG5032JUW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_924192_0_0_12"/>
    <dbReference type="OrthoDB" id="2129633at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="301" mass="35288" checksum="DAA408E600FDB618" modified="2004-07-05" version="1">MAKNMITALPFLLKKIYSIKMEKYSFQNRTHKLIAGIFLFIGFSFFCYAQEIPASPSDSDKIKIFSLEECNSLFAEYYRAGSIGDEDLKILTDGKNILTDSLEKILLENKKNRDIKKQNELLILYLKHAEIISTIYNYGSMNHQGEEIKKIDKDLKRFLKLSDLEGEVYLKYADYLYTKLKLPETNRFSTKLALPVLYRMALLKDKTNKAAFVKLSCWQISSADETTSNFNSQIKATEKYIEELNEIDRFNAFIWYSIFYMKIYDTKKGWKYFYKAKNLFPNHQIVLLLYENYKKGILGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R01</accession>
    <name>Q73R01_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase J</fullName>
            <ecNumber evidence="1">2.1.1.266</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (adenine(2030)-N6)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m6A2030 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmJ</name>
        <name evidence="2" type="ordered locus">TDE_0292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the adenine in position 2030 of 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(2030) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(6)-methyladenosine(2030) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43736"/>
            <dbReference type="Rhea" id="RHEA-COMP:10668"/>
            <dbReference type="Rhea" id="RHEA-COMP:10669"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.266"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RlmJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.266" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970906.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681232.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0292"/>
    <dbReference type="DNASU" id="2741383"/>
    <dbReference type="EnsemblBacteria" id="AAS10787">
        <property type="protein sequence ID" value="AAS10787"/>
        <property type="gene ID" value="TDE_0292"/>
    </dbReference>
    <dbReference type="GeneID" id="2741383"/>
    <dbReference type="KEGG" id="tde:TDE_0292"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.281"/>
    <dbReference type="eggNOG" id="COG2961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061769_0_0_12"/>
    <dbReference type="OMA" id="TYAIWYP"/>
    <dbReference type="OrthoDB" id="1186316at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036307">
        <property type="term" value="F:23S rRNA (adenine(2030)-N(6))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00934">
        <property type="entry name" value="23SrRNA_methyltr_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007473">
        <property type="entry name" value="RlmJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37426">
        <property type="entry name" value="PTHR37426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04378">
        <property type="entry name" value="RsmJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="1">
        <location>
            <position position="4"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="279" mass="31998" checksum="72AFA3DF39FE4C5B" modified="2004-07-05" version="1">MLSYRHGFHAGNQADVFKHSALFSFLKVYTQKQKPFTAFDLNAGSASYNLLSEWSLKTGEAEEGIIRFLDLYKKEKLPLPIPEGFKAYLDFCLKNYDENSSYAGSPEIIRSFLQKESNLILCDLHSAEAEKLKELYKRVENVHVHKRDCYEAVRALTPPLPIRGFALFDPSYEVDSDYTAIAESVEKVCKKWPIGIFIIWYPILNHKTEECRNLKDRISKAMNNKVLNIEVKHFSNKIDSENEYGLQGSGLLITNPPWGLEEKLKEICEYVEKVSAGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R56</accession>
    <name>Q73R56_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970851.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676581.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0235"/>
    <dbReference type="EnsemblBacteria" id="AAS10732">
        <property type="protein sequence ID" value="AAS10732"/>
        <property type="gene ID" value="TDE_0235"/>
    </dbReference>
    <dbReference type="GeneID" id="2739830"/>
    <dbReference type="KEGG" id="tde:TDE_0235"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.228"/>
    <dbReference type="eggNOG" id="ENOG5030Y2S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_197659_0_0_12"/>
    <dbReference type="OrthoDB" id="2084489at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="83" mass="9791" checksum="F28022FB59853497" modified="2004-07-05" version="1">MSDLLLKRYNLLPKEFQSEVQNYIEYLLLKSKKNNKGCSKKNGRKEKIVAYENLLNYTGCIPSDIDYKKEYMEAALKKYESIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R59</accession>
    <name>Q73R59_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Appr-1-p processing enzyme domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970848.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681144.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0232"/>
    <dbReference type="EnsemblBacteria" id="AAS10729">
        <property type="protein sequence ID" value="AAS10729"/>
        <property type="gene ID" value="TDE_0232"/>
    </dbReference>
    <dbReference type="GeneID" id="2739084"/>
    <dbReference type="KEGG" id="tde:TDE_0232"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.225"/>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_5_1_12"/>
    <dbReference type="OMA" id="HYGKGLP"/>
    <dbReference type="OrthoDB" id="1812319at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="176" mass="19150" checksum="41D3E6F4F51C6F92" modified="2004-07-05" version="1">MENTSTLIEIINADITKLKVDAIVNAANTTLLGGSGVDGAIHAAAGPELLEECRTLKGCKTGKAKITGAYKLPSKYIIHTPGPVYENGKNGEPELLANSYRSCLNLAFEYGCKSIAFPCISTGVYGYPKEEAAKIALNEISAFLKEHKDCMKVFIVCFGKENEEIYKKLMEKNYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R97</accession>
    <name>Q73R97_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970810.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681086.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0194"/>
    <dbReference type="EnsemblBacteria" id="AAS10691">
        <property type="protein sequence ID" value="AAS10691"/>
        <property type="gene ID" value="TDE_0194"/>
    </dbReference>
    <dbReference type="GeneID" id="2741613"/>
    <dbReference type="KEGG" id="tde:TDE_0194"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.190"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_729450_0_0_12"/>
    <dbReference type="OMA" id="FGEAFHI"/>
    <dbReference type="OrthoDB" id="856208at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="230"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="380" mass="43639" checksum="3B0C3DC7D3E46258" modified="2004-07-05" version="1">MQKRKFLWILVVGFLSVFLEAEDLSLSKEDLLVIQNPKGGYHLYIKAKPDIKSVLLTETTKDPDLKLDNYAYRDPNYNEINGDEKRLLNGEFLLPEKRLYSLIDSTPEKNTPLGEAYHIWIPYIILYGYDWSRSGEIEVKDGTFFNIRTFAKPYGDYTGNFQDNPFTLRVTQKPVEKDPPPDLSYSDEAVKTFTDLADTTEGEMIYAKGPEDILSTIKEILKKGEKDHLDLLFALDSTESMKDDVEEVRKNISSMLAETLPQYKTYRIALVLYKDYREDFLVREACVFTDNLKKFEKALYGFKVFGGRDIPEAVYEGIFLGLRQSWRALDADVDKKLILIGDAPPHPKPRGKVTKEDVDKLAAEKGVKIYPIILPHSLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RC0</accession>
    <name>Q73RC0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Nuclease SbcCD subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sbcD</name>
        <name evidence="8" type="ordered locus">TDE_0170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'-&gt;5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 6">Heterodimer of SbcC and SbcD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SbcD family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970786.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681053.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0170"/>
    <dbReference type="EnsemblBacteria" id="AAS10667">
        <property type="protein sequence ID" value="AAS10667"/>
        <property type="gene ID" value="TDE_0170"/>
    </dbReference>
    <dbReference type="GeneID" id="2739522"/>
    <dbReference type="KEGG" id="tde:TDE_0170"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.167"/>
    <dbReference type="eggNOG" id="COG0420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038045_0_1_12"/>
    <dbReference type="OMA" id="TSGNHDS"/>
    <dbReference type="OrthoDB" id="1831911at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004593">
        <property type="entry name" value="SbcD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00619">
        <property type="entry name" value="sbcd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="7">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS10667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="383" mass="43209" checksum="44A34598F0FD8AB1" modified="2004-07-05" version="1">MKILHTADLHLGKSLYESPQIERQKKMLDDIHKILLKDDYAALIIAGDIYDRSIPPAEYVALFDSFLSAVHKDCPNTAVFIIPGNHDSAERLSFGSKILSSSNIHIAAGIGKLCSPIIIAQNGEKVQFFLMPFLHLGSFSEENSELKLTSQSEMAQEASRRLKEAVDPSMPSVLAAHIFTLNGESSSSERAFLGTAEYVSPALFDFFTYTALGHLHKMQKVTDRMYYSGAPLTYAFDECSTEKVVLSVDVDCKTQGFPVRVEKIPISPLRKMSRLEGSFFEFFNTDKFDAYKDDFLEINLTGSAVIQSPMSLLQQKFPYLLNLHQEAVAAELKDEEQIHILKKNIEDEDVIFENFMLFEKTIDEEPSAKKQELFKSLCKEQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RE1</accession>
    <name>Q73RE1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase-related ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970765.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0148"/>
    <dbReference type="EnsemblBacteria" id="AAS10646">
        <property type="protein sequence ID" value="AAS10646"/>
        <property type="gene ID" value="TDE_0148"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0148"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.146"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_3_12"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="103"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="289" mass="33110" checksum="F11780122C0A6D59" modified="2004-07-05" version="1">MNLEAEGNQKHLSLIFKFLPLLCVFFNFDLIFFLFTLIIFFYSGVKENYLLKTLEVTGLKDKLAESKINSEKRERILENEVLKNAEVLILAERNRISGSLHNSIGHTLSAGILQVNALKYISNQEDVKESLNTLQNSLENGMTEIRECLHNMHNDSFNLQTGLEELVENTKKIKIQLTYKVDSIPYELKYDIFSIVKESLSNTIKHSGASELNLSVLEHLGFYSLIIKDNGRGFSGKQIRNLNYGIGLKVIADLVEKHRGIIKFYSENGFKTHIIFPKIKDKYNEDNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RG4</accession>
    <name>Q73RG4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970741.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666681.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0124"/>
    <dbReference type="MEROPS" id="S54.025"/>
    <dbReference type="EnsemblBacteria" id="AAS10622">
        <property type="protein sequence ID" value="AAS10622"/>
        <property type="gene ID" value="TDE_0124"/>
    </dbReference>
    <dbReference type="GeneID" id="2741739"/>
    <dbReference type="KEGG" id="tde:TDE_0124"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.124"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_4_1_12"/>
    <dbReference type="OMA" id="FILLAPW"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="49"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS10622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="209" mass="23488" checksum="7F5DB01D25B0AB29" modified="2004-07-05" version="1">MKYLRKPFKYTYKNAVLIIALINAGVFVFTSLFRNLSAYLGLVPILVVEAQTYWQFFTYQFVHGDFFHLAFNMLALFFFGVPVERKIGTKEFILYYLLIGTIGGILSFLVYAATGFYTITLIGASGAIFGVLLLYAVLYPNSVIYIWGVIPVPAPLLILGYAVIELISIFSIGDGVAHLTHFIGLIAGWVYIRIRFGIKPLKVWNSTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RI5</accession>
    <name>Q73RI5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase, class-V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970720.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680952.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0103"/>
    <dbReference type="EnsemblBacteria" id="AAS10601">
        <property type="protein sequence ID" value="AAS10601"/>
        <property type="gene ID" value="TDE_0103"/>
    </dbReference>
    <dbReference type="GeneID" id="2741718"/>
    <dbReference type="KEGG" id="tde:TDE_0103"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.103"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_12"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="2"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="380" mass="41692" checksum="BE3524599DBE25A0" modified="2004-07-05" version="1">MIYLDWAATALPQEDIITEALKKAFKYFANPSSKHFLGKDARKILEDTRLEIAELLNTAPDHIIFTSGGTEGDYIPMLSLLALPSPCSIAVSSIEHSAVREQAAVMKARGYKILQIPSDKNGFISADAVLKTIDSNTAFVSVMAVNNETGAIQPIAEIGKALEEYSKGKRKIHFHTDAVQAIGKIPFELSKLSIHSASFSGHKIGAPRGIGFLYLAKNMEAFIRGGGQENGLRPGTENLAGILALSGCLKKYYENLDGYVFHAKELMDFLIEELAGIEGLSFIPESRPQLKDKYSPWILQFSVKELTGEVLVRCLSEKGICISTGSACSSKKRTRPVLEAMKIDAKVQQNSVRVSIGPLTQRGELEVFVKTLKEILIEFR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RJ5</accession>
    <name>MURB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="1">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murB</name>
        <name type="ordered locus">TDE_0093</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970710.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680945.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73RJ5"/>
    <dbReference type="SMR" id="Q73RJ5"/>
    <dbReference type="STRING" id="243275.TDE_0093"/>
    <dbReference type="EnsemblBacteria" id="AAS10591">
        <property type="protein sequence ID" value="AAS10591"/>
        <property type="gene ID" value="TDE_0093"/>
    </dbReference>
    <dbReference type="GeneID" id="2741708"/>
    <dbReference type="KEGG" id="tde:TDE_0093"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.94"/>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035304_1_1_12"/>
    <dbReference type="OMA" id="MQNIGAY"/>
    <dbReference type="OrthoDB" id="841869at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000224735" description="UDP-N-acetylenolpyruvoylglucosamine reductase">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <sequence length="323" mass="35334" checksum="F242577023F16D5A" modified="2004-07-05" version="1">MNNLFSILHNTPLFQEGTIEFYKPLKPLTSYKIGGPAEALFCPKDEDHLKEALIFLSKNKISASLIGGGTNILVSDKGFRGVLISLKNLNKIEIIGESENKVFVRAGAGVLTDKLTKWAVENSLSGLECFGGLPGSVGGAVFMNARCYDVSISDRLKSIKYILADGDKTEFAEYEYNPSDWDYKASPFQQNPVSTEITKNRKIVLSAVFTLTHGIKEEIAVKTEEKVQDRISKGHFKEPSAGSTFKNNRAFGLPSGKLIEDAGLKGLCEGGAQVAPWHGNFIINKHDASASDIKTLIEKVQKTVKDKTGFLLEPEVIFAGDWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RK6</accession>
    <name>Q73RK6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970699.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680938.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0082"/>
    <dbReference type="EnsemblBacteria" id="AAS10580">
        <property type="protein sequence ID" value="AAS10580"/>
        <property type="gene ID" value="TDE_0082"/>
    </dbReference>
    <dbReference type="GeneID" id="2741697"/>
    <dbReference type="KEGG" id="tde:TDE_0082"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.83"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045945_4_2_12"/>
    <dbReference type="OMA" id="AKGNRMF"/>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="105" mass="11910" checksum="31BDA8D1C428B30B" modified="2004-07-05" version="1">MNGFSIGEVEKITGIKSHTLRYWEDNIPVLQPKKDLGGRRIYSSHDLGIIYRLDYLINKKKYTVEGAAAEIINQSAAQGSLTAKISELRDQLLDIYGIIREEKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RL0</accession>
    <name>Q73RL0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycine reductase complex selenoprotein GrdB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">grdB-1</name>
        <name evidence="1" type="ordered locus">TDE_0078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970695.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0078"/>
    <dbReference type="KEGG" id="tde:TDE_0078"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.79"/>
    <dbReference type="eggNOG" id="COG1978">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053106_0_0_12"/>
    <dbReference type="OrthoDB" id="571652at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050485">
        <property type="term" value="F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010187">
        <property type="entry name" value="Various_sel_PB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07355">
        <property type="entry name" value="GRDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01918">
        <property type="entry name" value="various_sel_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0711">Selenium</keyword>
    <keyword evidence="1" id="KW-0712">Selenocysteine</keyword>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="1">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="443" mass="48464" checksum="E5A239D0FE8B77BD" modified="2008-02-26" version="2">MIYKAIHYINQFYAGIGGESSADSGFVVLRDKKGPAIGLEGLWHGKMIVTKVICCGDNYINLDRNFEEVCRQLKKIVEEEKPDVLIAGPAFNAGRYGMACAKICDYVRSNLNLPSVTAMWHENPAVKIYVRNNYIISSTETAAGMHKTLQDLADLALKLAKKEKIGPARIEGYLPTGHRYNEYHKKTGAERVVDMLLDKLNGRPYQTEVPLRGFERVPPAPPIHKMNKTTIALFTTGGLVPIGNPDKLKQAFAEDFKVYDISNRDTLPQGVYESIHGGYDTTAASAEPNRLIPLDALRQCEAEGIIGGIYPYFGTTCGVGTNVAVSESMGKAWARKIKEEGVGAVILTSTUGTCTRCGATICKELDRVGIPNVHINAFTSISESVGANRIVFGGGFTAPVGNPMLPLERETAYRRKIVDKALEALQTEVLSPTVFTVDHDKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RP7</accession>
    <name>Q73RP7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fabF</name>
        <name evidence="14" type="ordered locus">TDE_0038</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970655.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673329.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0038"/>
    <dbReference type="EnsemblBacteria" id="AAS10536">
        <property type="protein sequence ID" value="AAS10536"/>
        <property type="gene ID" value="TDE_0038"/>
    </dbReference>
    <dbReference type="GeneID" id="2741653"/>
    <dbReference type="KEGG" id="tde:TDE_0038"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.40"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_12"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="4"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAS10536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="411" mass="43162" checksum="1B285F5AC25A20F8" modified="2004-07-05" version="1">MRRVVITGLGAVTPIGNTLDETWEGIKAGKCGIGNITQFDCSDFKIQIAAEVKNFDASQFMDKKDARKMARFTQFAVAAASQAMKDAGLSKENIDANRTGIILGNGIGGFEIYQEAFKKYFQVAPDRIPPMTVPLLIPNEAAGNISMQFGIKGPSWTLATACASGTDALGNALDLVRSGRLDVCVSGGTEATITGFGISGFTILQTLASGDPAKACCPFDKKRSGFVMGEGSGILILEEYEHAKKRGAKIYAEFAGYGASSDAYHLTSPDPSGDGGALAITNALADAGVKPEEVQYYNAHGTSTPINDPAETAMIKKAFGDHAYKMKVSSTKSMIGHCLGAAGALEAIFCIKAMEEGFYPPTINLTEPDLEAGCDLDYVPNKGVKGEINCAASGSLGFGGHNGVAVFKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RR1</accession>
    <name>Q73RR1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase, family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970641.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680883.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0024"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10522">
        <property type="protein sequence ID" value="AAS10522"/>
        <property type="gene ID" value="TDE_0024"/>
    </dbReference>
    <dbReference type="GeneID" id="2741639"/>
    <dbReference type="KEGG" id="tde:TDE_0024"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.26"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008392_5_3_12"/>
    <dbReference type="OMA" id="MFMISYP"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="70"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="557" mass="61834" checksum="0850F185C30D9E13" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RS8</accession>
    <name>Q73RS8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970624.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680862.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0007"/>
    <dbReference type="EnsemblBacteria" id="AAS10505">
        <property type="protein sequence ID" value="AAS10505"/>
        <property type="gene ID" value="TDE_0007"/>
    </dbReference>
    <dbReference type="GeneID" id="2741622"/>
    <dbReference type="KEGG" id="tde:TDE_0007"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.8"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057504_0_2_12"/>
    <dbReference type="OMA" id="WDEGHTE"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="284" mass="33482" checksum="68C713AD27132BEF" modified="2004-07-05" version="1">MQKLFKITLRNDYAFKRIFGVEENKDVLQDLLECILDIPPENIAGLELLDKEFHKELLSEKLGILDIKLRLKDGTFVDIEIQNNWHFDFPERTLYYWSKMYNEAIKQGQDYTNLPKCITINLIGKGFDKNKRLHNKYLVLEKDTKEPLASKLEIHILNLEKARLLKEGQFKDNKTKRLLSWLKFIETDNPEVREMLEQESTMMKKANAAISVMEMSPRDKWLYDSRMKYEHDRASCISEGYRQGLDKGAYQNKLETAKLMKKMNYPISDICTISGLTKEEIEKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-10" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>P61310</accession>
    <name>RRF_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-recycling factor</fullName>
            <shortName evidence="1">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">frr</name>
        <name type="ordered locus">TDE_2345</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972944.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675802.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61310"/>
    <dbReference type="SMR" id="P61310"/>
    <dbReference type="STRING" id="243275.TDE_2345"/>
    <dbReference type="EnsemblBacteria" id="AAS12863">
        <property type="protein sequence ID" value="AAS12863"/>
        <property type="gene ID" value="TDE_2345"/>
    </dbReference>
    <dbReference type="GeneID" id="2739440"/>
    <dbReference type="KEGG" id="tde:TDE_2345"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2213"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_12"/>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="OrthoDB" id="1674344at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000167569" description="Ribosome-recycling factor">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <sequence length="185" mass="20879" checksum="F5B890520944D21C" modified="2004-05-10" version="1">MIEEVKKNCEEKMKKTVVALKEEFNMLRTGRASSALFDKIRVNCYGESTPLNQLANISIPEARLVVIQPWDKGLLVEIEKAVLQADLSVNPTNDGKVIRIAIPPLTEDRRKDLAKKAKTIAENSRVSVRNIRRDGIDEAKKLQKDGKISEDQLKTAEDAFQKSTDAYIAEINKVLEAKEKEIMEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-06-21" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>P62056</accession>
    <name>LDH_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-lactate dehydrogenase</fullName>
            <shortName evidence="1">L-LDH</shortName>
            <ecNumber evidence="1">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ldh</name>
        <name type="ordered locus">TDE_0351</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970965.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002684979.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P62056"/>
    <dbReference type="SMR" id="P62056"/>
    <dbReference type="STRING" id="243275.TDE_0351"/>
    <dbReference type="EnsemblBacteria" id="AAS10846">
        <property type="protein sequence ID" value="AAS10846"/>
        <property type="gene ID" value="TDE_0351"/>
    </dbReference>
    <dbReference type="GeneID" id="2740158"/>
    <dbReference type="KEGG" id="tde:TDE_0351"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.340"/>
    <dbReference type="eggNOG" id="COG0039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_1_1_12"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="870724at2"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000168409" description="L-lactate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="120"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>beta-D-fructose 1,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="1">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00488"/>
        </source>
    </evidence>
    <sequence length="315" mass="33603" checksum="60F90E68BA73B192" modified="2004-06-21" version="1">MDEKKRKVTVVGAGAVGSTFAYALAQSGYADEIAITDMNKNFAEGQALDLVQGLPFLPQVDIHAGDKTDYADSDIVVVTAGAKQQSGETRIDLLKRNASIITGIAKDIAESGCSGVMLIVSNPVDILTRAALKASGWERGRVIGSGTVLDTARFRYTLSKECGVDARNIHGYILGEHGDSEFAAWSMTSVAGRRIDEYCSGGVCSSGPHFDKAKILEEVRNSAYHIIDYKGSTYFAVGLALTRIAGAILRNEHSILSVSMTLDGEFGLKDVCLSVPCIVGRSGAERVIESDLPADEQAALEASAKRLKEAFTEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J00</accession>
    <name>Q73J00_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973375.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680840.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2777"/>
    <dbReference type="EnsemblBacteria" id="AAS13294">
        <property type="protein sequence ID" value="AAS13294"/>
        <property type="gene ID" value="TDE_2777"/>
    </dbReference>
    <dbReference type="GeneID" id="2740744"/>
    <dbReference type="KEGG" id="tde:TDE_2777"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2621"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070820_0_0_12"/>
    <dbReference type="OMA" id="RGWNSTQ"/>
    <dbReference type="OrthoDB" id="685252at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047746">
        <property type="term" value="F:chlorophyllase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015996">
        <property type="term" value="P:chlorophyll catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017395">
        <property type="entry name" value="Chlorophyllase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07224">
        <property type="entry name" value="Chlorophyllase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="319" mass="36620" checksum="97F7701663802FF1" modified="2004-07-05" version="1">MNSHLQDEHKIFEGPYDIRAYNDKNMIGFNRVYKKTLETNKEDKSLSNEENLRDEVTVYIPKKKGKYPLILVSHGWANYKYGLLPIGHYLASYGYAVALFTSKKKAVPKDWIPTFTAVHNLIKNKNEDASHDLYGLIDINNIGIVTHSMSGPASFYYASLMPEVKAISAIHPYNGASPFVEAIASSNKELGDEFPKIKSAVLFLTSEIDRSAYPEKTYKFFKNLNKDAPACFLSFKNIKHNGALDIFKTPLSGGYDEKAFKLYSRLSVLWFDAFLKGKKENLKYFQIDDEKFQDIKDLLYTEIHREHEAYPSYDSRNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J74</accession>
    <name>Q73J74_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973300.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673491.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2702"/>
    <dbReference type="EnsemblBacteria" id="AAS13219">
        <property type="protein sequence ID" value="AAS13219"/>
        <property type="gene ID" value="TDE_2702"/>
    </dbReference>
    <dbReference type="GeneID" id="2739289"/>
    <dbReference type="KEGG" id="tde:TDE_2702"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2551"/>
    <dbReference type="eggNOG" id="ENOG5032XTS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030185_0_0_12"/>
    <dbReference type="OrthoDB" id="1520094at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285792" evidence="1">
        <location>
            <begin position="20"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="580" mass="66152" checksum="D01F1109D866657B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J81</accession>
    <name>Q73J81_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="11" type="ordered locus">TDE_2695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973293.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673498.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2695"/>
    <dbReference type="EnsemblBacteria" id="AAS13212">
        <property type="protein sequence ID" value="AAS13212"/>
        <property type="gene ID" value="TDE_2695"/>
    </dbReference>
    <dbReference type="GeneID" id="2739282"/>
    <dbReference type="KEGG" id="tde:TDE_2695"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2545"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_322611_0_0_12"/>
    <dbReference type="OMA" id="KKALHRY"/>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="746"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="822"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS13212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="901" mass="104908" checksum="8B563B65FCECEF93" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J83</accession>
    <name>Q73J83_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
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                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
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                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
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                <person name="Shatsman S."/>
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                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
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                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
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                <person name="Weinstock G.M."/>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
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                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
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                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
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                <person name="Fouts D.E."/>
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                <person name="Daugherty S.C."/>
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                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
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                <person name="Tsegaye G."/>
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    <sequence length="262" mass="29956" checksum="195C53B60FAC2687" modified="2004-07-05" version="1">MANTDYENIPEEELWDKYKKTSDPKIREYFILKYAPLVKYVAGKVGIGMPTNVEFDDLVGYGVFGLLDAIEKYDLDKNVKFNTYAVNRIRGAIFDELRSIDWVPRSVRQKSREIEETIADLEARLGRSASNEEIAYAMGLDIEEYNSLLLKISATSVISLTDLRFSNDDSEEFSVGDIIEAPSSLNPDVIVEREDIKRVIVEAIKELPDREKKVLIMYYYEDMTLREIGEVLHVTESRVSQIHTSANIKLRAKLSNVTKGIK</sequence>
</entry>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Eisen J.A."/>
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                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
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                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
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                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
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                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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            <begin position="20"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="270" mass="29398" checksum="554D14C36B6FF3EB" modified="2004-07-05" version="1">MKKNILGIAIFSCMLSLSAFDFMNISGDVGIGYMNYTIVNNYDTGKLADNLSAELKALIGPGNLKLGSIKAKDSYNAFMVGLSFKMSYIYANINVGFPLKEISSGFDPLAQKLKEKGISDKINGSIIFDSQIGVGITLMKSSPLNIFVGGGLGINYIRTTRDLPGNFISSLSDVTSLKEIRSVGMIGLGADIGIKYFFMPKIGICLDLKDTIYFLPLANQRYYSGKLKNGIPFTYSINSETNTNSGDIKKLIKSTWANNFSVRLGVAFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JF7</accession>
    <name>Q73JF7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973216.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680625.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2618"/>
    <dbReference type="EnsemblBacteria" id="AAS13135">
        <property type="protein sequence ID" value="AAS13135"/>
        <property type="gene ID" value="TDE_2618"/>
    </dbReference>
    <dbReference type="GeneID" id="2740792"/>
    <dbReference type="KEGG" id="tde:TDE_2618"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2475"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067347_0_0_12"/>
    <dbReference type="OMA" id="CTWGGAT"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="291" mass="32137" checksum="0821771E07527B4B" modified="2004-07-05" version="1">MVDLHTHSTASDGTFTPAELAAAVKKAGISAFALTDHDILSGLDEAAAEAKRQGIIFIRGVEISVKWSPGELHLLGLDLRKDSRELNSLLQDLQDERINRNQRMAEKLKKAGFDISYEKVRDFAGGDKGLGRPHFAAYMAAHKMVKKNQDAFDKYFAKGRPFFEEKENAELAAAISAVKSAGGIPVLAHPMSLYLSWSSLPDVIADFKRQGLVGLEAWNSSTKYNDCKRLEKLAASLDMPVTAGSDFHGSIRKDRKLGTTSKNCIKIEDRFYENLRALHPDLPPLQDSQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JK2</accession>
    <name>Q73JK2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973015.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680353.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2416"/>
    <dbReference type="EnsemblBacteria" id="AAS12934">
        <property type="protein sequence ID" value="AAS12934"/>
        <property type="gene ID" value="TDE_2416"/>
    </dbReference>
    <dbReference type="GeneID" id="2739841"/>
    <dbReference type="KEGG" id="tde:TDE_2416"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2282"/>
    <dbReference type="eggNOG" id="ENOG503025Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1785754_0_0_12"/>
    <dbReference type="OMA" id="WNFPFKS"/>
    <dbReference type="OrthoDB" id="1666377at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="147" mass="17323" checksum="FE9D4C8F678DF3F9" modified="2004-07-05" version="1">MCKECYVNENRITPLLNPVDCLENHTQYICGTCGRCICIEHDPQRGLQRWNFPFKSLEIAKLYLRTADYTEKKACGIYEIENSKGKKSYKIFPSYDDLLLFLKKNKDKQCKQTAPLFTVGKYKEYPHTQIRMLTSAEVKKYMSEREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JQ5</accession>
    <name>Q73JQ5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMI1_KNR4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973052.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680409.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2453"/>
    <dbReference type="EnsemblBacteria" id="AAS12971">
        <property type="protein sequence ID" value="AAS12971"/>
        <property type="gene ID" value="TDE_2453"/>
    </dbReference>
    <dbReference type="GeneID" id="2739638"/>
    <dbReference type="KEGG" id="tde:TDE_2453"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2321"/>
    <dbReference type="eggNOG" id="COG4282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113681_0_0_12"/>
    <dbReference type="OrthoDB" id="1776264at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SSF160631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMI1_KNR4" evidence="1">
        <location>
            <begin position="40"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="194" mass="23021" checksum="EF3F38EA8D8D27FB" modified="2004-07-05" version="1">MELIDNIKKIETYVCENFEEWGLDDPIEEEYFQEYESIAGASQHDLLKFEEEFSICLPEDFKTLYQYKDGSRFMCILPSMIGTSDMCFCLMSLTEIKKCKTYFQNKKALLSNFPKYFSSQDIDNMQDNRIKPYLFNKRWIPFAQYCDSCYLMLDFDPDTEGKKGQVICYIHDPDEIVYVSKNITELIEKITEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JQ9</accession>
    <name>Q73JQ9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973073.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680439.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2475"/>
    <dbReference type="EnsemblBacteria" id="AAS12992">
        <property type="protein sequence ID" value="AAS12992"/>
        <property type="gene ID" value="TDE_2475"/>
    </dbReference>
    <dbReference type="GeneID" id="2741448"/>
    <dbReference type="KEGG" id="tde:TDE_2475"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2341"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_1_12"/>
    <dbReference type="OMA" id="YILIYGN"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="463" mass="51304" checksum="756A85235F17B1FA" modified="2004-07-05" version="1">MVTNLKHKYFGPFSFYKNAVKLAVPVMVQLFIQSLVSLIDNFMVADLGDLKMSGVNVANQIIFVYITGLNILCSAGGMFMSQYNGTKDEEGMQQAYRFKQISGIIFALALLGICLTIPDLVLGLLVNGNTAKKEIVEQAVIYSNVILLSFIPTAFSIGIASSFRETGNVKVPMYISLVSTLINTIGNYMLIYGNLGAPRLEVAGAAYATVIARCAELIIFVLYAKKVKPLFYVKIKEMLKIKLHLFYEILKKSALIFVADMSWVLSEIVATAVYNSRGGTEVVAGMSAGWTIANLFFLVFPAIGTSVGVIIGGTLGRNKLEEAREQARWIKRGAFVLGLGTSLLELFSIMLVPIVFRSLSPASHEVTRLLIIFIALYMPVWTFQNTQYAIARSGGDAVMGVWVDTTVNMFLFMPCMLLLYYFTDWSSPIMYAIAKLTSIMKAVLAEVQLKKERWVKNLTRIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JR7</accession>
    <name>Q73JR7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_2467</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973065.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680420.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2467"/>
    <dbReference type="EnsemblBacteria" id="AAS12984">
        <property type="protein sequence ID" value="AAS12984"/>
        <property type="gene ID" value="TDE_2467"/>
    </dbReference>
    <dbReference type="GeneID" id="2739652"/>
    <dbReference type="KEGG" id="tde:TDE_2467"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2334"/>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064908_0_0_12"/>
    <dbReference type="OMA" id="FLGCPWR"/>
    <dbReference type="OrthoDB" id="1104816at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026366">
        <property type="entry name" value="Seleno_YedE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04112">
        <property type="entry name" value="seleno_YedE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="206"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="349" mass="36647" checksum="4D95BC32ADC39CF6" modified="2004-07-05" version="1">MKKHLMVIVTGAVIGIAALVLVRFGNPGNMGFCIACFLRDIAGALKLHNAGVVQYMRPEVIGLIIGAFVLAFVKKEFKPRGGSAAFTRFTLGFFVMIGALVFLGCPLRMFLRLGAGDLNAVFGLVGFIAGIVIGIFFLNKNFSLSRAHNQSKQEGVIPIIFMIIFFVLLVAFPSALAFSEKGPGSMKAPIFLALAIGLVVGGLAQRSRMCTVGGIRDAIMLKDFHLLWGSLTILVTVVVGSLILGKFNLGFAGQPVAHTDGLWNALGMVLVGWASVLLGGCPLRQLILTGEGNSDSAITVVGLIAGAAFAHNFGLASSGKGPTSAGMIAVVVGLILTAFVSIYYSLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JW2</accession>
    <name>Q73JW2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MAF_flag10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973123.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680487.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2525"/>
    <dbReference type="EnsemblBacteria" id="AAS13042">
        <property type="protein sequence ID" value="AAS13042"/>
        <property type="gene ID" value="TDE_2525"/>
    </dbReference>
    <dbReference type="GeneID" id="2739037"/>
    <dbReference type="KEGG" id="tde:TDE_2525"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2389"/>
    <dbReference type="eggNOG" id="COG2604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033812_0_0_12"/>
    <dbReference type="OMA" id="YLWAHFP"/>
    <dbReference type="OrthoDB" id="1153411at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAF_flag10" evidence="1">
        <location>
            <begin position="204"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="582" mass="65830" checksum="C700D97C835B03BB" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K01</accession>
    <name>Q73K01_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA interferase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973162.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673725.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2564"/>
    <dbReference type="EnsemblBacteria" id="AAS13081">
        <property type="protein sequence ID" value="AAS13081"/>
        <property type="gene ID" value="TDE_2564"/>
    </dbReference>
    <dbReference type="GeneID" id="2739929"/>
    <dbReference type="KEGG" id="tde:TDE_2564"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2423"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_1_1_12"/>
    <dbReference type="OMA" id="VFNHSRI"/>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="112" mass="12521" checksum="1D8136DA7BF2F897" modified="2004-07-05" version="1">MTRGDVYMLDFGIPAGSEPGMRRPVIIIQSDKKNLNSLNTKIVVPLTSNTVNAELKGNVFIPKNESQLPKNSVALVHQIIVVDKSRLEEKVGKVSKHILLQIEQEIDYVLKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-29" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K18</accession>
    <name>G6PI_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="1">GPI</shortName>
            <ecNumber evidence="1">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoglucose isomerase</fullName>
            <shortName evidence="1">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphohexose isomerase</fullName>
            <shortName evidence="1">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgi</name>
        <name type="ordered locus">TDE_2573</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973171.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680556.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73K18"/>
    <dbReference type="SMR" id="Q73K18"/>
    <dbReference type="STRING" id="243275.TDE_2573"/>
    <dbReference type="EnsemblBacteria" id="AAS13090">
        <property type="protein sequence ID" value="AAS13090"/>
        <property type="gene ID" value="TDE_2573"/>
    </dbReference>
    <dbReference type="GeneID" id="2739938"/>
    <dbReference type="KEGG" id="tde:TDE_2573"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2432"/>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017947_3_1_12"/>
    <dbReference type="OMA" id="IGVWYIN"/>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000180760" description="Glucose-6-phosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <sequence length="525" mass="58030" checksum="57A70CF75C24C579" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K33</accession>
    <name>Q73K33_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidase</fullName>
            <ecNumber evidence="4">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase C69 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="4"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973182.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680570.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2584"/>
    <dbReference type="MEROPS" id="C69.001"/>
    <dbReference type="EnsemblBacteria" id="AAS13101">
        <property type="protein sequence ID" value="AAS13101"/>
        <property type="gene ID" value="TDE_2584"/>
    </dbReference>
    <dbReference type="GeneID" id="2741288"/>
    <dbReference type="KEGG" id="tde:TDE_2584"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2443"/>
    <dbReference type="eggNOG" id="COG4690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014823_4_2_12"/>
    <dbReference type="OMA" id="TWYGQKL"/>
    <dbReference type="OrthoDB" id="414486at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070004">
        <property type="term" value="F:cysteine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005322">
        <property type="entry name" value="Peptidase_C69"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12994">
        <property type="entry name" value="PTHR12994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03577">
        <property type="entry name" value="Peptidase_C69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="483" mass="54897" checksum="34E47E47FF5BE97C" modified="2004-07-05" version="1">MNNVKSFSAHTDCTTVLVGKKASIDGSILIARNEDFHLAISPKIFVLEKAVNEANRIYKSKNTGVEIPLPAKAYRYTSVPQAYPNDKENQGVYGEAGINEKNVALSSTESVYGNAKVLAYDPLVKNGIAEDAINDIVLPFINSAREGVSYLGKLIEKYGSAEGNGILFADLDEIWYMEIPCGHHWVAVRIPDDCYAVAPNQVSIEKIDFKKPDYYMWSKGIKEFVNEHKLNPDRDGFNFRHIFGTSSEKDRVYNTPRAWFAQKYLNPEIEQSPVSNDIPFIQKANRLISVEDVEYILSSHYNETEFDPIGIGNSEFNKTRFRGISLSRTAESHILQLRPKSPKRLEGIQWLALGTTAFVPYIPFFTNILDTPTAYKRMTRMVSTDNAYWLFKLIGHFVEAHYSAFKDDNNAYLIEMQSYGRARVKEITDAAAKIPAKSLSEFLTEENRKTAEHVLKRTKEYLSDLMLESFKYSKLSFTMDKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K65</accession>
    <name>Q73K65_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron compound ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972956.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680276.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2357"/>
    <dbReference type="EnsemblBacteria" id="AAS12875">
        <property type="protein sequence ID" value="AAS12875"/>
        <property type="gene ID" value="TDE_2357"/>
    </dbReference>
    <dbReference type="GeneID" id="2739966"/>
    <dbReference type="KEGG" id="tde:TDE_2357"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2225"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_1_1_12"/>
    <dbReference type="OMA" id="VFIWIVR"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="327" mass="35047" checksum="07B108B871F49C2D" modified="2004-07-05" version="1">MLEERRRKMLIFLFISCILLALSVLAAIYFGSTKIPLSEIIKIIFYHENSDFAIIIWDIRMPRIILALIVGANLAASGALLQAVIQNPLADPGIIGISSGAKLGLLLALLIFPQFVTAAPLFAFAGAMGAAVLVYLLAWKGGVKTVRLILAGVAVNAFFAGVSYLITILNNDKIQNIMLWLSGNLSGRSMYDVKLILPYSLIGLAAALAAIRPSNLLLFGDEKAGSLGLNITRSRILISLTASFLAAISTSLVGVISFVGLVIPHIVRLITGPNYKYLLPLSILNGGIFLLIADTFARTIAAPIELPVGTLMALVGGPFFVYLLRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K69</accession>
    <name>Q73K69_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Flagellar hook-associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_2353</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the core of the flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasmic flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972952.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680271.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2353"/>
    <dbReference type="EnsemblBacteria" id="AAS12871">
        <property type="protein sequence ID" value="AAS12871"/>
        <property type="gene ID" value="TDE_2353"/>
    </dbReference>
    <dbReference type="GeneID" id="2739962"/>
    <dbReference type="KEGG" id="tde:TDE_2353"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2221"/>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024437_7_0_12"/>
    <dbReference type="OMA" id="INRVSHP"/>
    <dbReference type="OrthoDB" id="1788350at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013384">
        <property type="entry name" value="Flagell_FlgL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010810">
        <property type="entry name" value="Flagellin_hook_IN_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07196">
        <property type="entry name" value="Flagellin_IN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02550">
        <property type="entry name" value="flagell_flgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="8">
        <location>
            <begin position="333"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="415" mass="45970" checksum="ACF244C78224A708" modified="2004-07-05" version="1">MMKRISTNIQHTDSNFSMRNQESRLHNLNNQIQSQRRINQLRDDPVSAGHSVRYKSYLARLERFEKNTKTLRDQYMSAETYMNNSLQVVQRLRELSVQGANGTYTPDDLKDMAAEADELLKELVQNGNAVNSDGVRVFSGTKSFTEPFETVMGDVDGAGSALITQVRYNGTVDSKEVETDELSFMRADQAGNRVFWAERQILISETDARNFVIKEDTSIEVDGVEIPLIAGDNVYAIMSKINDSGAAVKASLDPITSGLNLTTTDARQLWLRDAEGSTVLSELGLIKAEQRPPYNLANSVRVSGGSLFDAAIAVRDAFLSGDQEALGGKVLGSLDEGIHNLTTRMAETGSKYSRAEVILARIDTQTLNVTAAESREADLDITKAITDLKMFEHTHQASLSVLGRLYRDSLLNYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K80</accession>
    <name>Q73K80_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972939.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667749.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2340"/>
    <dbReference type="DNASU" id="2739435"/>
    <dbReference type="EnsemblBacteria" id="AAS12858">
        <property type="protein sequence ID" value="AAS12858"/>
        <property type="gene ID" value="TDE_2340"/>
    </dbReference>
    <dbReference type="GeneID" id="2739435"/>
    <dbReference type="KEGG" id="tde:TDE_2340"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2208"/>
    <dbReference type="eggNOG" id="COG3976">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096350_2_2_12"/>
    <dbReference type="OMA" id="LTAVEDC"/>
    <dbReference type="OrthoDB" id="1230380at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285922" evidence="1">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="FMN_bind" evidence="2">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="120" mass="13305" checksum="0AA6E7B4A5C6AACF" modified="2004-07-05" version="1">MKKICFTIIVFALSIFLFSCNVKNDEKIVSGIFEGKAESLMGNISVRVVIEKSEIKNIDILEYADTPGYSDTVFEYLPKRVIEKDSTDVDLVAGATLTSKAFLEAVNDALKKAGLYVEKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K92</accession>
    <name>CLPB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">clpB</name>
        <name type="ordered locus">TDE_2327</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The Clp repeat (R) domain probably functions as a substrate-discriminating domain, recruiting aggregated proteins to the ClpB hexamer and/or stabilizing bound proteins. The NBD2 domain is responsible for oligomerization, whereas the NBD1 domain stabilizes the hexamer probably in an ATP-dependent manner. The movement of the coiled-coil domain is essential for ClpB ability to rescue proteins from an aggregated state, probably by pulling apart large aggregated proteins, which are bound between the coiled-coils motifs of adjacent ClpB subunits in the functional hexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972927.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680241.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73K92"/>
    <dbReference type="SMR" id="Q73K92"/>
    <dbReference type="STRING" id="243275.TDE_2327"/>
    <dbReference type="PRIDE" id="Q73K92"/>
    <dbReference type="EnsemblBacteria" id="AAS12846">
        <property type="protein sequence ID" value="AAS12846"/>
        <property type="gene ID" value="TDE_2327"/>
    </dbReference>
    <dbReference type="GeneID" id="2739422"/>
    <dbReference type="KEGG" id="tde:TDE_2327"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2196"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_2_12"/>
    <dbReference type="OMA" id="SKMMQGE"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000191196" description="Chaperone protein ClpB">
        <location>
            <begin position="1"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Clp R" evidence="2">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Repeat 1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Repeat 2" evidence="2">
        <location>
            <begin position="83"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="NBD1" evidence="1">
        <location>
            <begin position="159"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="1">
        <location>
            <begin position="341"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="NBD2" evidence="1">
        <location>
            <begin position="559"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal" evidence="1">
        <location>
            <begin position="767"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="391"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="206"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="609"/>
            <end position="616"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="859" mass="96644" checksum="B06E50D67353DFD6" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KI1</accession>
    <name>Q73KI1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972837.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2237"/>
    <dbReference type="EnsemblBacteria" id="AAS12756">
        <property type="protein sequence ID" value="AAS12756"/>
        <property type="gene ID" value="TDE_2237"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2237"/>
    <dbReference type="HOGENOM" id="CLU_3376604_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="34" mass="4010" checksum="4F686AF05F087A53" modified="2004-07-05" version="1">MKKIANYKKIFIIDIKNFFAELSVFSRFTPTAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KI9</accession>
    <name>Q73KI9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972829.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2229"/>
    <dbReference type="EnsemblBacteria" id="AAS12748">
        <property type="protein sequence ID" value="AAS12748"/>
        <property type="gene ID" value="TDE_2229"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2229"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2105"/>
    <dbReference type="HOGENOM" id="CLU_2572854_0_0_12"/>
    <dbReference type="OrthoDB" id="1834457at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="81" mass="9588" checksum="E5DF2E971B4B1502" modified="2004-07-05" version="1">MLRTLMQDSQMDQFFLVGGTSIALRLGHRKSIDLDLFTQNDIDFIHEPVNLIVGKFNWEHIEKRLHDMIKNPQEIYTTYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KN8</accession>
    <name>Q73KN8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Voltage-gated chloride channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972780.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2179"/>
    <dbReference type="EnsemblBacteria" id="AAS12699">
        <property type="protein sequence ID" value="AAS12699"/>
        <property type="gene ID" value="TDE_2179"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2179"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2056"/>
    <dbReference type="eggNOG" id="COG0038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015263_7_4_12"/>
    <dbReference type="OMA" id="PMISGSG"/>
    <dbReference type="OrthoDB" id="1560952at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="442"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="528" mass="56867" checksum="2D7C71E9C2339C72" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KP4</accession>
    <name>Q73KP4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972774.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2173"/>
    <dbReference type="EnsemblBacteria" id="AAS12693">
        <property type="protein sequence ID" value="AAS12693"/>
        <property type="gene ID" value="TDE_2173"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2173"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2051"/>
    <dbReference type="eggNOG" id="ENOG5031RNT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153097_1_0_12"/>
    <dbReference type="OrthoDB" id="1936474at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024215">
        <property type="entry name" value="DUF3847"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12958">
        <property type="entry name" value="DUF3847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="83" mass="10171" checksum="224F8293764C675F" modified="2004-07-05" version="1">MKNIEEKILMADEEIKQLQNKRKKLISQQKQEERKKRDKRIYEKGAVFESIFTESKNLTKDEFYQLITSQRNKDEINLKNHRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KZ3</accession>
    <name>RLMN_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="1">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmN</name>
        <name type="ordered locus">TDE_2074</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972675.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679871.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KZ3"/>
    <dbReference type="SMR" id="Q73KZ3"/>
    <dbReference type="STRING" id="243275.TDE_2074"/>
    <dbReference type="EnsemblBacteria" id="AAS12586">
        <property type="protein sequence ID" value="AAS12586"/>
        <property type="gene ID" value="TDE_2074"/>
    </dbReference>
    <dbReference type="GeneID" id="2741201"/>
    <dbReference type="KEGG" id="tde:TDE_2074"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1959"/>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029101_0_0_12"/>
    <dbReference type="OMA" id="QVGCSLD"/>
    <dbReference type="OrthoDB" id="1111428at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000350508" description="Probable dual-specificity RNA methyltransferase RlmN">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="100"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="1">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="160"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="215"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="(transient)" evidence="1">
        <location>
            <begin position="107"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="347" mass="38599" checksum="9DD5BE63F6623DBF" modified="2004-07-05" version="1">MTIKKYKTALSGMFPEEIQSFCGLKEKFRAQQIFHWIASGVNSFDEMTNLSFDMRSKLKNDFSLFSTKIKEALKDKDGTIKLAVELYDGSVIETVLLTDKAKRKTACVSCQAGCPMKCAFCKTGQIGFLRNLSASEIVEQFLHLEREAGSLDNIVFMGMGEPMLNLPEIDKAINILAHPKGRNLSKRRITISTSGLCKGIYEMADKGPEVRLAVSLTTADETLRSELMPITKTNSLDELKQAIKYFNSKSNKRVTLELALMKGLNTDKKAAQEVIEFAKGLECFINLIPWNPVEGLNFKTPSETEVRTFETYLKKAGLNISTRQKRGQSIGGACGQLGSTAARSNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L16</accession>
    <name>Q73L16_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972652.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2050"/>
    <dbReference type="EnsemblBacteria" id="AAS12563">
        <property type="protein sequence ID" value="AAS12563"/>
        <property type="gene ID" value="TDE_2050"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2050"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1936"/>
    <dbReference type="eggNOG" id="ENOG502ZCTH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174115_0_0_12"/>
    <dbReference type="OMA" id="YDEDCPP"/>
    <dbReference type="OrthoDB" id="1855549at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025528">
        <property type="entry name" value="BrnA_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14384">
        <property type="entry name" value="BrnA_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="77" mass="8856" checksum="B569EE6C560EBFA6" modified="2004-07-05" version="1">MPIVYDEDCPPLTKEQIKEFARIAKEQRKLRKKQVVAIRLSPETAEKVKALGKGYSSVLSRIIDEAFRNPELLQKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L36</accession>
    <name>Q73L36_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, TatD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2029</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972632.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2029"/>
    <dbReference type="EnsemblBacteria" id="AAS12543">
        <property type="protein sequence ID" value="AAS12543"/>
        <property type="gene ID" value="TDE_2029"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2029"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1914"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_3_12"/>
    <dbReference type="OMA" id="HIYASEF"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="284" mass="32166" checksum="A95922C323F59138" modified="2004-07-05" version="1">MERKFRFAMDIGTQPADLKERQKFISDIFEGKIQGQETVHLPERFPDFMHFAAGLWPHAESIAEPEKALAALKTDIDTLFLQKAEAEKTNPGKPFYCGLGECGLDRYWNGPAAEKRGAGSQADDEKGTSDIEGEEFLFKEQLKIAKEKNLSVIVHSRDAYEDTLKCIDEVGYHKGIIHCYSYGLKEAYSFLERGWYISFPGNITYAKKQADRDRIAELVRAIHADKLLLETDAPYLAPVPFRGKINTPLLIEYTYAAVSEILDKSMEALAEQIYQNCCSCFLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L53</accession>
    <name>Q73L53_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972615.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675442.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12526">
        <property type="protein sequence ID" value="AAS12526"/>
        <property type="gene ID" value="TDE_2012"/>
    </dbReference>
    <dbReference type="GeneID" id="2740359"/>
    <dbReference type="KEGG" id="tde:TDE_2012"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1900"/>
    <dbReference type="HOGENOM" id="CLU_1474553_0_0_12"/>
    <dbReference type="OrthoDB" id="2118372at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="183" mass="21439" checksum="F2E1284883E67F61" modified="2004-07-05" version="1">MNYEKVNAKACLIASVFLGIVYVLIFYFFPSAKENMKYKNIDFWELVHALKILYLCLFGLGVSFYKFSFKLLRTKIENIYPKLIKFLLAVFKILLYITSFLLSKTYISIFDPKPKFIFFVIHILFLIVGIVQNIITEAVFDFHSDNYNHPYLQLILGKFVFILCALPLYVDFLGGVYLLLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L94</accession>
    <name>Q73L94_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA polymerase III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972574.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679703.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1971"/>
    <dbReference type="EnsemblBacteria" id="AAS12485">
        <property type="protein sequence ID" value="AAS12485"/>
        <property type="gene ID" value="TDE_1971"/>
    </dbReference>
    <dbReference type="GeneID" id="2741534"/>
    <dbReference type="KEGG" id="tde:TDE_1971"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1863"/>
    <dbReference type="eggNOG" id="COG0470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052177_0_0_12"/>
    <dbReference type="OMA" id="QEIRASW"/>
    <dbReference type="OrthoDB" id="1971388at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="429" mass="48441" checksum="0097E57FE2A5F59C" modified="2004-07-05" version="1">MFENLIDQEAGLRLIQDIKQKKLPPSILFSGPECSGKLTAALELARSVSCTESGNWTCTCSSCLRQKEMIAPDVLILGARDHSPEIKAACETLLKTKTLSSRYLFLRAIRKLTARFDPRLWDTDETRFVKAAPVIAEIEELLADLCSGPIETIDDNVLNKTAEALVLKAAKLQDECMYDTIPINQVRKASSWVRLMPSGIKKVLIVENADKMQEGARNAFLKILEEPPSYAVFILTTAHRGAIMPTILSRVRTYTFKERDKKSQEEVIRRVFKGEPCHEPFGKFNLLSSYLYGFLPVSFRAIQNAAALFYEYVFLLIDRQNKILPSALYNSISNYKNKNKYDNSNCTVSNIVNLLNKCKPHTIYILFLNSLLFFLQDGLKNEECSALEVESYFKITALIKNAEAAVDIFNISPQAALENLAEEIKEKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L95</accession>
    <name>Q73L95_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensory box histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972573.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679701.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1970"/>
    <dbReference type="EnsemblBacteria" id="AAS12484">
        <property type="protein sequence ID" value="AAS12484"/>
        <property type="gene ID" value="TDE_1970"/>
    </dbReference>
    <dbReference type="GeneID" id="2741533"/>
    <dbReference type="KEGG" id="tde:TDE_1970"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1862"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_39_12"/>
    <dbReference type="OMA" id="EIMLTTA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="116"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="182"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="415" mass="46418" checksum="B6A6E93DE593DA35" modified="2004-07-05" version="1">MREFMRRGIQKSPNMNEAQLRTFVKLLANEYSLLDSVMDSLNDGVIVADSENKIIKSNRAAERILGTSFRGTSLRSTSLGGSALGEGHEKNVWEHIKIQDIADFVSSVIQNESGQTSKEFNLKADKPEGKNKYIEVSVLPLVNEKKIQGTIIMIADITEKRIEEIKNRRLENLASLTNVAAAVAHEIKNPLAAISIHLQLLKKNFTACNLSINQKAQKHIGVIEEEIERLNKIVVDFLFAVRPLKFEFVPVDINALLKNLYDTFFDEFNDSGIAISLSFSKELPKIQGDERFLRQAFMNVLTNAKSAMPNGGFLDISTKAVNDFIIVTISDSGQGILPEDMHKIFEPYFTTKHDGTGLGLTMTYKVIKEHGGDINVYSDYGMGTSFKFSLPIERKGAMLLLSDKTFDFDSVKDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LA4</accession>
    <name>Q73LA4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972564.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679685.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1961"/>
    <dbReference type="EnsemblBacteria" id="AAS12475">
        <property type="protein sequence ID" value="AAS12475"/>
        <property type="gene ID" value="TDE_1961"/>
    </dbReference>
    <dbReference type="GeneID" id="2741524"/>
    <dbReference type="KEGG" id="tde:TDE_1961"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1853"/>
    <dbReference type="eggNOG" id="COG2402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143452_1_1_12"/>
    <dbReference type="OMA" id="LGHGRIF"/>
    <dbReference type="OrthoDB" id="1669086at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="141" mass="16474" checksum="1C34BDDDBE047DFB" modified="2004-07-05" version="1">MLNTVLIDTGPLIALFDKDDKYHLSVIDFIKDGNYRFVSTIAVLTEVMYMLDFNIKVQINFLEWVMKKGLIIHDINKNTIKRISELINKYSDRPMDFADATLVAAAEERGINRIISIDSDFDIYRLHGKLKIENIFKKRFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LC1</accession>
    <name>Q73LC1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972547.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669773.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12458">
        <property type="protein sequence ID" value="AAS12458"/>
        <property type="gene ID" value="TDE_1944"/>
    </dbReference>
    <dbReference type="GeneID" id="2740184"/>
    <dbReference type="KEGG" id="tde:TDE_1944"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1836"/>
    <dbReference type="eggNOG" id="ENOG5033TSC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1460697_0_0_12"/>
    <dbReference type="OMA" id="IYTAKNQ"/>
    <dbReference type="OrthoDB" id="1551109at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="185" mass="21157" checksum="30A67DECA1F77E41" modified="2004-07-05" version="1">MSNLKAIDLFEAYAQNKLPMDEGYIVSSFFKEDSAYSVYEIISYSTVKDIYMTGDGLTFQTNGKKLFLLVEPPNFPHKAVEPVFRDKNFQVPLRFKESNIYTAKNQSTIIYSNAPQKAISTFTVVKPVGINFAFLFYPLPNTFKLIERFFEKTLNQEAVIPVDDAKKVAKDFAALCEKVLTWSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LF3</accession>
    <name>Q73LF3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972514.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1911"/>
    <dbReference type="EnsemblBacteria" id="AAS12425">
        <property type="protein sequence ID" value="AAS12425"/>
        <property type="gene ID" value="TDE_1911"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1911"/>
    <dbReference type="HOGENOM" id="CLU_3105029_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="51" mass="6252" checksum="6A1C4A7ED271E060" modified="2004-07-05" version="1">MTSSLFCNIIDFILFYLRRAGMPCGKKRKRKKMSTHKRKKKLRKNRHKNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LN7</accession>
    <name>Q73LN7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972429.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957070.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1825"/>
    <dbReference type="EnsemblBacteria" id="AAS12340">
        <property type="protein sequence ID" value="AAS12340"/>
        <property type="gene ID" value="TDE_1825"/>
    </dbReference>
    <dbReference type="GeneID" id="2740487"/>
    <dbReference type="KEGG" id="tde:TDE_1825"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1731"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061987_0_0_12"/>
    <dbReference type="OrthoDB" id="1472463at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH_5" evidence="1">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="364" mass="41969" checksum="6012CD3FEAB18199" modified="2004-07-05" version="1">MSTCYLCKNEITEQNITIEHIILNSMGGRLKSSNLICKECNSKFGDSFDAKLSKQFEFFANILDIKRERGKVQDVIMVRESTGEEYRVTPDGKPIVNKPTIERKEIENGEEIHIQARNLDELKKILVGLKKKYPAINIDECLKKAKHIKERLSEPLGITLTLGGRDSMPAILKMAINFFVEITRDVVTVSEAIEDLRKNSTDKVEPIILEESLFDLGENEVTHSIFLNASPEEKKVYAIIELYGTIQFIVKLSKNYNGNAFIKLYVYDVLLTKEIQKKVNYIPDFNYIFSHEYPKSNPNFQILNDKMSHVMQIAMKRKNNSFISEIIKKSFDNTWGKLPEGKIITNEDVDMCLDELMKNIELYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LN8</accession>
    <name>Q73LN8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972428.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12339">
        <property type="protein sequence ID" value="AAS12339"/>
        <property type="gene ID" value="TDE_1824"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1824"/>
    <dbReference type="HOGENOM" id="CLU_3367952_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="35" mass="4485" checksum="F1075D154FC1AB17" modified="2004-07-05" version="1">MRLVRNVRLKRVLDENIYLFYIFYYLNTKKYSHNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LS2</accession>
    <name>Q73LS2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972394.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681202.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1790"/>
    <dbReference type="EnsemblBacteria" id="AAS12305">
        <property type="protein sequence ID" value="AAS12305"/>
        <property type="gene ID" value="TDE_1790"/>
    </dbReference>
    <dbReference type="GeneID" id="2741234"/>
    <dbReference type="KEGG" id="tde:TDE_1790"/>
    <dbReference type="eggNOG" id="ENOG5033020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1989870_0_0_12"/>
    <dbReference type="OMA" id="KENYLIY"/>
    <dbReference type="OrthoDB" id="1733128at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="128" mass="15558" checksum="27175BE0D25094AA" modified="2004-07-05" version="1">MVQYNMDKENYLIYEGVFFRIEWFYDKAGYSQAFEYFRKASPSQKRKFLMLIKKIGDFGKIFDKTKFRYEGDEIYAFKPQPDRYLCFFKKGQKIIVTNGFCKRTNKLPLAEKTIALENKKIYEHLYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LS5</accession>
    <name>Q73LS5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972391.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672992.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1787"/>
    <dbReference type="EnsemblBacteria" id="AAS12302">
        <property type="protein sequence ID" value="AAS12302"/>
        <property type="gene ID" value="TDE_1787"/>
    </dbReference>
    <dbReference type="GeneID" id="2741231"/>
    <dbReference type="KEGG" id="tde:TDE_1787"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1700"/>
    <dbReference type="eggNOG" id="COG5304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171731_0_0_12"/>
    <dbReference type="OMA" id="ASIVHKY"/>
    <dbReference type="OrthoDB" id="1933588at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="85" mass="10007" checksum="51EB3CA088E24325" modified="2004-07-05" version="1">MNSEKELYESIENDEWKSVKNFYDLSNDFKKAAESMLMKSEKIDIMLVKQDMNNLKAKAFEEGMEYEVFAGSILHKYLTGKLIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LS6</accession>
    <name>Q73LS6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972390.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957043.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1786"/>
    <dbReference type="EnsemblBacteria" id="AAS12301">
        <property type="protein sequence ID" value="AAS12301"/>
        <property type="gene ID" value="TDE_1786"/>
    </dbReference>
    <dbReference type="GeneID" id="2741230"/>
    <dbReference type="KEGG" id="tde:TDE_1786"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1699"/>
    <dbReference type="eggNOG" id="ENOG50348WC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_799111_0_0_12"/>
    <dbReference type="OrthoDB" id="2103235at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="347" mass="40846" checksum="A264128DC484770E" modified="2004-07-05" version="1">MEYAIKILKENKALLENNKAKNSQEILELKKAIDSLTIIENSKIDYLSLSNNFASHTCTLWTAYDEGKEFFIPQIDKIHNDLLKDMEKKYNELEDNIKKQSDSEILVKFLDDQSNEEYELENMMRSLKSVYDEIKKLTNEYYGTDLYKGYWYLYSEIYFDFKCKYFQAGINRRQSADLDIFTLAKDLIHHYFVFTSPIIPSAIILIRQSIEVKILQTFGIKEFKNEKGEIATIPISRLLAFSKEKCNKNLLEFPIDIDLLIAINRWCNSYIHTGFFLSQNWLVERIISVLCTLFLEPAYGKTCFDLEGSIKIKEEYLDNGFYSDLQEFLSKKGNKIYIEKTAHRFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LV5</accession>
    <name>Q73LV5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972361.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12272">
        <property type="protein sequence ID" value="AAS12272"/>
        <property type="gene ID" value="TDE_1757"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1757"/>
    <dbReference type="HOGENOM" id="CLU_3085895_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="52" mass="6276" checksum="2A5FCCBBB2FA77D5" modified="2004-07-05" version="1">MNIIVVINPIFKKQVSSEIIYFLTPLIIKNRERKKTTLKKIIKNINLFQLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LW9</accession>
    <name>Q73LW9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1743</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972347.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679462.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1743"/>
    <dbReference type="TCDB" id="2.A.51.1.6">
        <property type="family name" value="the chromate ion transporter (chr) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12258">
        <property type="protein sequence ID" value="AAS12258"/>
        <property type="gene ID" value="TDE_1743"/>
    </dbReference>
    <dbReference type="GeneID" id="2740588"/>
    <dbReference type="KEGG" id="tde:TDE_1743"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1666"/>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018106_1_2_12"/>
    <dbReference type="OMA" id="GMTLSVQ"/>
    <dbReference type="OrthoDB" id="1884249at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="187" mass="20361" checksum="E940776243C9F906" modified="2004-07-05" version="1">MSLIGLFFLFMYIGFCTIGGGLVAITLMQQELIPRGLISSEDFFAMVAISESTPGPMGINMATYIGYELYGVLGSVVLTTGIVLPSLVVIVLIARFASSFQEKPLVKKSFYGLRAGAVGMITVACWQVINISILNLSAFRASGKLADIVHIKQFVFFWLLFFVSIFFKKLHPIVLVAAGAIFGVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LY0</accession>
    <name>Q73LY0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972336.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679454.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1732"/>
    <dbReference type="EnsemblBacteria" id="AAS12247">
        <property type="protein sequence ID" value="AAS12247"/>
        <property type="gene ID" value="TDE_1732"/>
    </dbReference>
    <dbReference type="GeneID" id="2739190"/>
    <dbReference type="KEGG" id="tde:TDE_1732"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1656"/>
    <dbReference type="eggNOG" id="COG2214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1000924_0_0_12"/>
    <dbReference type="OMA" id="REDWMDC"/>
    <dbReference type="OrthoDB" id="1322159at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="228"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="278" mass="33197" checksum="359E56989AE7D365" modified="2004-07-05" version="1">MIKKDDNYALLGISPEASVAEIKTAFRKKAKLHHPDLIQYKTGEEKEKSESAMRLLLNAYQNILKEKTNSENPFDYFDFFSKKNPAESFDYRLWLLKKTDYESRAKLIFFDLFHGLEQSAVEEYNKRRSEAGGFYLSKYFNREDFMDCGFVLAEDLYFRGEYYESFLLLEEIFYLEKQKPYFKHFFPEVTDLIKSIIIDKLHRYVEDELAIDCYEAALELGFKKVDRANILKRMSEIYYRFGDSYKASQYVNEAMKLNPKLRGIKIIQNQLENHYDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LY6</accession>
    <name>Q73LY6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PolyA polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972330.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669419.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1726"/>
    <dbReference type="EnsemblBacteria" id="AAS12241">
        <property type="protein sequence ID" value="AAS12241"/>
        <property type="gene ID" value="TDE_1726"/>
    </dbReference>
    <dbReference type="GeneID" id="2739184"/>
    <dbReference type="KEGG" id="tde:TDE_1726"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1650"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_0_1_12"/>
    <dbReference type="OMA" id="DDPVRMI"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004652">
        <property type="term" value="F:polynucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006378">
        <property type="term" value="P:mRNA polyadenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010206">
        <property type="entry name" value="PolA_pol_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01942">
        <property type="entry name" value="pcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="5">
        <location>
            <begin position="50"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="6">
        <location>
            <begin position="202"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="380" mass="43798" checksum="EC401A75DF484B38" modified="2004-07-05" version="1">MLVRYGQNAEGKQVRQALVYTKDEHKIALEKIDIEAVKIIQRLNSQGFEAYIVGGAVRDLLIGHVPKDFDIATSAEPSKIRKMFRNSRVIGRRFRLVHIFFGEKIYEVSTFRSTEDGSIGNKFGTIDEDVHRRDFTLNALYYDPIHELVIDYVDGVKDIRAKKIRPIIPLQLIFSEDPVRMIRAIKYAAMTDSGIPFFLQLQIRKNAHLLEFVSPSRITEEINKIIFSGHASDIIKKLLDFKLYVYLQPGACAFIDSSSKFKKIYIENLALLDKEVDAKPQIKQGECLKSLLKDYIRLIANPEGPPQEVYTYVYKECRHFILPMNPQRKELEFAVKSVLNDLGIKVSMDRTQVRPAKLGKQVKHRRKKKAKKQEALKDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M05</accession>
    <name>Q73M05_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence/damage-inducible protein CinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cinA</name>
        <name evidence="2" type="ordered locus">TDE_1706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972310.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678481.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1706"/>
    <dbReference type="EnsemblBacteria" id="AAS12221">
        <property type="protein sequence ID" value="AAS12221"/>
        <property type="gene ID" value="TDE_1706"/>
    </dbReference>
    <dbReference type="GeneID" id="2740878"/>
    <dbReference type="KEGG" id="tde:TDE_1706"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1631"/>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_1_2_12"/>
    <dbReference type="OrthoDB" id="1947628at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA" evidence="1">
        <location>
            <begin position="6"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="192" mass="20726" checksum="178846E1C8787124" modified="2004-07-05" version="1">MIDFELIKKVFFVLRERGIKLITAESLTGGLIASEFTKISGASEVLWGGYIVYTPQAKISLLNIEPDIIDSFGVVSPQTVEAMALGAVKNFFNASCAPEPAVSIAVSGVAGPSSLEGNPPGTVCVSSAFFCPAPSDLKILKKDAFVFKTHTYRFSGSRDEVREQTVNKAFLHVLSLTEKTAAPIRNCRDFKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M40</accession>
    <name>Q73M40_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972275.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679365.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1670"/>
    <dbReference type="EnsemblBacteria" id="AAS12186">
        <property type="protein sequence ID" value="AAS12186"/>
        <property type="gene ID" value="TDE_1670"/>
    </dbReference>
    <dbReference type="GeneID" id="2739011"/>
    <dbReference type="KEGG" id="tde:TDE_1670"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1596"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_11_0_12"/>
    <dbReference type="OrthoDB" id="1381274at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="31"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="182" mass="21422" checksum="621FDF2F05CD74CA" modified="2004-07-05" version="1">MLNDIYKNEIINAWVEDNEPVDLIEKRYKNISNIVDGMYDFVLSFSYYYTIRRDYGTGKKYTMIEMHILTDIYDNENITVSALAKKWNRTSSAISQIVHRLIKWGLVYKEVNQADGKVFFLHTTEKAKKTVLTHKAYDNKDNVKTRKKLLETFTVDEMVAFDKILKAYTDILEKNNSKNKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ME3</accession>
    <name>Q73ME3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972171.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12082">
        <property type="protein sequence ID" value="AAS12082"/>
        <property type="gene ID" value="TDE_1565"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1565"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1499"/>
    <dbReference type="eggNOG" id="ENOG5032MSM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148085_0_0_12"/>
    <dbReference type="OrthoDB" id="2115278at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="149" mass="17694" checksum="A6E455C08B66906B" modified="2004-07-05" version="1">MNMSCKIIIERAEIVNGYSKQLLNIAKIKHINLDVFFQAYKGIEGIVVDRESIYSNCICVDQNHNINNKCYGFDVGILDIDYYSFSSIYNEIIFSSYDFFYKYKENLNNFFLFPTYYEASQFLNFHKQIYEEGNDVEHTDLLSIYRILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MN5</accession>
    <name>Q73MN5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellin FlaG, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972079.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668949.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1473"/>
    <dbReference type="EnsemblBacteria" id="AAS11990">
        <property type="protein sequence ID" value="AAS11990"/>
        <property type="gene ID" value="TDE_1473"/>
    </dbReference>
    <dbReference type="GeneID" id="2741588"/>
    <dbReference type="KEGG" id="tde:TDE_1473"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1414"/>
    <dbReference type="eggNOG" id="COG1334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120910_6_2_12"/>
    <dbReference type="OMA" id="RATEGEF"/>
    <dbReference type="OrthoDB" id="1924509at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005186">
        <property type="entry name" value="FlaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035924">
        <property type="entry name" value="FlaG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37166">
        <property type="entry name" value="PTHR37166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03646">
        <property type="entry name" value="FlaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160214">
        <property type="entry name" value="SSF160214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="123" mass="13756" checksum="38482AC02ABE89F8" modified="2004-07-05" version="1">MSIEINGIGHQAALQQKRDTVINGSMRAASDVIVQKEAAEQAENQKTLVDPNEISKAVAQIQKLCDMCDRKLQFRVNKETNRIVVKVIDANTDKVIREIPSEAIQRLQARILETVGLLFDESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MQ0</accession>
    <name>Q73MQ0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MAF_flag10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972064.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679115.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1458"/>
    <dbReference type="EnsemblBacteria" id="AAS11975">
        <property type="protein sequence ID" value="AAS11975"/>
        <property type="gene ID" value="TDE_1458"/>
    </dbReference>
    <dbReference type="GeneID" id="2741573"/>
    <dbReference type="KEGG" id="tde:TDE_1458"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1399"/>
    <dbReference type="eggNOG" id="COG2604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037954_1_0_12"/>
    <dbReference type="OMA" id="THARPYS"/>
    <dbReference type="OrthoDB" id="912403at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAF_flag10" evidence="1">
        <location>
            <begin position="165"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="509" mass="58155" checksum="AAB17653543F6AB7" modified="2004-07-05" version="1">MIKQVKLHSSYNPQKEAERFSDTIQGNPKIIVITEPGESYLASALRKKFPKAKLMAMRYTDNYFLESDKFWDRVWRPASGNPSFFLVNNIPDEFLSSTLFLPWKPAEKVWPDSASWVWKEISEAVKIIQSLIATRSFFGKRWLKNMGDNFIFTEKPVNLDFFGENNIENNEPSFFAGAGPSLDEVLDNYSDNINEIFNMAAASALPAVLSRNIKLDLCVSTDGGFWAANHLKYLKDEKFKETALAFPLEAKIPYQILKNNNCLFLSYGSSLENLFFTNLGITPIPAKRNGTVSGTAIELLLDEAGGKIFIAGLDLKESKGFSHCSPHESQIQKEIKANRLDTLSTFAAISNFDLRSLKTYEKWFSRIPVPRAERLFRIGKDLPPLGNIKSIDGEDFKAQTRGRENTNKKTIQVRRLEHKTPKEKKAMLSAIYQNIKEEIKNKTFFDKIKISAKEKELSSPEKELCEFISFQNYMTFLKEKDSHNEAEIKLKLEDEISSFLENQIGRLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MR7</accession>
    <name>Q73MR7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbA</name>
        <name evidence="7" type="ordered locus">TDE_1440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972046.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679070.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1440"/>
    <dbReference type="EnsemblBacteria" id="AAS11957">
        <property type="protein sequence ID" value="AAS11957"/>
        <property type="gene ID" value="TDE_1440"/>
    </dbReference>
    <dbReference type="GeneID" id="2741403"/>
    <dbReference type="KEGG" id="tde:TDE_1440"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1381"/>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_9_0_12"/>
    <dbReference type="OMA" id="FTWLDTG"/>
    <dbReference type="OrthoDB" id="1004719at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="291" mass="32310" checksum="E1E81144118548DB" modified="2004-07-05" version="1">MKAIILAGGAGTRLYPLTKAVSKQILPMYDKPMIYYPLSVMMLAGIREVLIISTPRDIGLFKELFSDGNWLGMRFEYAVQDKPRGLADAFIVGEKFIGADSCALVLGDNIFYGRGFSSTLADAVSSIKDNGGALIFGYYVKDPRAYGVVDFDDKGNVLSIEEKPQNPKSNYAIPGLYFYDNEVIQIAKSIKPSARGEIEITSVNNAYLAMGKLRVEKLGRGMAWLDTGTYDGLLEASNFIATIQKRQGMYVSCIEEIAYLQKWISKTQLLNLSSSYNNEYGDYLKYIAENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MW1</accession>
    <name>Q73MW1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase, family 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972001.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956965.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1395"/>
    <dbReference type="CAZy" id="GH57">
        <property type="family name" value="Glycoside Hydrolase Family 57"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11912">
        <property type="protein sequence ID" value="AAS11912"/>
        <property type="gene ID" value="TDE_1395"/>
    </dbReference>
    <dbReference type="GeneID" id="2741262"/>
    <dbReference type="KEGG" id="tde:TDE_1395"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1337"/>
    <dbReference type="eggNOG" id="COG1449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026700_0_0_12"/>
    <dbReference type="OMA" id="HFMSAGL"/>
    <dbReference type="OrthoDB" id="94039at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015179">
        <property type="entry name" value="A-amylase/a-glucTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09095">
        <property type="entry name" value="DUF1926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="1">
        <location>
            <begin position="32"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1926" evidence="2">
        <location>
            <begin position="421"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="627" mass="72362" checksum="3318DD1B5D88B6BE" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MX8</accession>
    <name>Q73MX8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1378</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971984.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956960.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1378"/>
    <dbReference type="EnsemblBacteria" id="AAS11895">
        <property type="protein sequence ID" value="AAS11895"/>
        <property type="gene ID" value="TDE_1378"/>
    </dbReference>
    <dbReference type="GeneID" id="2741139"/>
    <dbReference type="KEGG" id="tde:TDE_1378"/>
    <dbReference type="HOGENOM" id="CLU_3159000_0_0_12"/>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="48" mass="5832" checksum="F0463E2AFC539E52" modified="2004-07-05" version="1">MTAKEVLKLLKQNGWYICETKGSHYQLKHLKIKRYKMRNKIYGICIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="135" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N11</accession>
    <name>Q73N11_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 16" type="primary">dnaG</name>
        <name evidence="16" type="ordered locus">TDE_1345</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971951.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678905.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1345"/>
    <dbReference type="EnsemblBacteria" id="AAS11862">
        <property type="protein sequence ID" value="AAS11862"/>
        <property type="gene ID" value="TDE_1345"/>
    </dbReference>
    <dbReference type="GeneID" id="2739446"/>
    <dbReference type="KEGG" id="tde:TDE_1345"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1293"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013501_3_3_12"/>
    <dbReference type="OMA" id="LMWPIRD"/>
    <dbReference type="OrthoDB" id="1071997at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:DNA primase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dnaG"/>
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    </dbReference>
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        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="257"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AAS11862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="595" mass="67563" checksum="1A4385D004638A92" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N21</accession>
    <name>Q73N21_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alginate O-acetylation protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_1335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
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        <property type="protein sequence ID" value="AAS11852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956953.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1335"/>
    <dbReference type="EnsemblBacteria" id="AAS11852">
        <property type="protein sequence ID" value="AAS11852"/>
        <property type="gene ID" value="TDE_1335"/>
    </dbReference>
    <dbReference type="GeneID" id="2741069"/>
    <dbReference type="KEGG" id="tde:TDE_1335"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1283"/>
    <dbReference type="eggNOG" id="COG1696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025255_4_1_12"/>
    <dbReference type="OMA" id="YAYFFTD"/>
    <dbReference type="OrthoDB" id="1297594at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="490" mass="57303" checksum="8FA50E1DFC21698C" modified="2004-07-05" version="1">MFFPTISFAVFFLSVFFLYWYIFRQEKERKILLTAASYFFYAMWDWRFCILLFVFTLINYFYGFLLDKEKNYAPRKAIVIIICIIDILYLGFFKYLYTLLSYLNQFFPDMFVNSTLLTLRSWSLLVPVGISYYTFRCMSYVFDIYLCKIRHVKSFWDFLLYVSFFPQLSSGPIVQAEYFFKDLPRALNCDNEKGAKPIAFDRAIVFLISGLYKKMIISNFLTILVTDKIFANPSFYNTWELIFGLLCYTIIIYADFSGYSDMAIGIGILLGFNTPANFNRPYVSKSITEFWRRWHISFSSWLRDYLYFGLGGSRFGLARALFALFFTMLIAGLWHGASWTFLIWGAMQGTMLCIEKIFSEIKERKAIGEEILDEEKDAKKSFDFLRIIPVFIFVNISWLVFFSPSLSELSLYLRSLGNISQPFQIISPFILLIFFAGLSLQLPSESLRKKAFTIYSRLPMIVKVVTTVSFLAALYAVSTSGIPPFIYFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N57</accession>
    <name>Q73N57_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971905.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671534.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1299"/>
    <dbReference type="EnsemblBacteria" id="AAS11816">
        <property type="protein sequence ID" value="AAS11816"/>
        <property type="gene ID" value="TDE_1299"/>
    </dbReference>
    <dbReference type="GeneID" id="2741053"/>
    <dbReference type="KEGG" id="tde:TDE_1299"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1249"/>
    <dbReference type="eggNOG" id="COG1896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672030_0_0_12"/>
    <dbReference type="OMA" id="ASKWEFD"/>
    <dbReference type="OrthoDB" id="1251692at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="196"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="398" mass="46813" checksum="61BA0B9A913BF7EF" modified="2004-07-05" version="1">MIFTTKTVLKLFEAFSIQRWNDLIRPFEIVEMDKTAEKTFLAYIIGKYEEKKGKKIDWDRIIDGSVFDILRKIALCDIKAPVQRRIRKEYPEEYKKINEWIFEKYNDIFPDGEFKAKFHSYLFEEPDKDDITWKVSRAAHKYSTIREFEMLKPVNEAFRLTEIDGFLKEEICEFMDLTGIQLLLANQNPHKLITEIEKLRFQIRWNQTPRVPPTTVLGHSFYVAALTLLMCYDLNINNERRYNNFFSALFHDLPEAVTRDIISPVKQATDHLPAVVKEIEDRIVKDELLPLMDESFIDEVMYYISDEFENRVIVNKQVKIVSFEELSQKYADKEFKATDGRLVRVADQIAAFVEAESSIKYGITSKHLEEGRKNILGAYPVGTKINNLSTDVFFNAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N86</accession>
    <name>Q73N86_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971876.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678772.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1269"/>
    <dbReference type="EnsemblBacteria" id="AAS11787">
        <property type="protein sequence ID" value="AAS11787"/>
        <property type="gene ID" value="TDE_1269"/>
    </dbReference>
    <dbReference type="GeneID" id="2740562"/>
    <dbReference type="KEGG" id="tde:TDE_1269"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1220"/>
    <dbReference type="eggNOG" id="ENOG5031DAN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118621_0_0_12"/>
    <dbReference type="OrthoDB" id="1746003at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="229" mass="26267" checksum="878EC27B9189CACE" modified="2004-07-05" version="1">MILFKNYIKKISFVLFLSLALSAYGFDLNSYWSLGDVKFGGIFQAQKPKAAWDLNISAFKFYFKDLNSGFNLSLSPFYMDIKGNNKEIENINGESNQRTAFFKHGLFIMSFINAELSFNTLNSISDTFELNLFTSIHAVDPVIISRFQINAGLEFAITKEIYPFAGRKYPLKSKLLSARTGFRYTDNKPFFFCDIGFDLGAILFIFKGDYEKAKEKAEKETIKDIFDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NA2</accession>
    <name>Q73NA2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971860.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678760.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1253"/>
    <dbReference type="EnsemblBacteria" id="AAS11771">
        <property type="protein sequence ID" value="AAS11771"/>
        <property type="gene ID" value="TDE_1253"/>
    </dbReference>
    <dbReference type="GeneID" id="2741429"/>
    <dbReference type="KEGG" id="tde:TDE_1253"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1205"/>
    <dbReference type="eggNOG" id="ENOG5031C8Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_573559_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="476" mass="54859" checksum="96A2B1AB8A948C57" modified="2004-07-05" version="1">MAKERARKQAASGIRLLILFFLFSLYPGLIYAGIEKDPELSFSSGPLFIDSVFEIKIKLDEYSSRSSDEPKLIILDEDSVLEFLDSSINSLYGGILITNRYKLKKIGNFELIPYLYLGKYQTKLKKFSIQVEPPALSKDTMFKWKILDAVSYSPVKKIIQGKKYLIVLMGFFYDYVQTEGRTSGLDINCQAPEDSIFEAAVRIKESDTSKIERTIIDETGWKAVSYFFWTPLKAGDIGLPVAQISIASESKDSRKIYVREQRVNVIKGSLKQEKISDDEKKAYETLGPALNTKKNELGQTKLKNHKENFEEKKEKALLIAELRTKEAGSFFPGKIKNQRLEYEKELNLKESFAVRSAILKKILWFLFFILLLLSSYFFLYKKKNIVFKLFLILSLGLISVLIFLYSRQYERAVYRPLNYDEPYLLYHIPETSGTIVSSLEIGETVIIKQKTSEWFFIEKKDGTGGWQKKNSFIITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ND4</accession>
    <name>Q73ND4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase, family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971828.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678712.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1221"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11739">
        <property type="protein sequence ID" value="AAS11739"/>
        <property type="gene ID" value="TDE_1221"/>
    </dbReference>
    <dbReference type="GeneID" id="2740115"/>
    <dbReference type="KEGG" id="tde:TDE_1221"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1176"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008392_0_2_12"/>
    <dbReference type="OMA" id="WQMAAEM"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_3" evidence="2">
        <location>
            <begin position="34"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="400" mass="45318" checksum="EE3DDA98F29D18AF" modified="2004-07-05" version="1">MKRFIPAFFYCFFIYTALFSDNESIKAYISEMSIEDKAAQVLMMSIEGKKTFPPYLSSYFDSYTPGAFVLFGYNFSDTPEACASYIKSVKQSIQNLSKSKTFVPPFFASDFEGGRVYRIRKIGSPLPSPREVAETLTEEGALALYTHTAEQIHLLGIHLNLAPIVEKERSKDAGFLDDRIFSNDEDVLVKYADAFISGMKKGGLLSTVKHFPGNAETDPHFSKSIIDVDENIFYKDFISPFRRILYGTDEAVLISHAEVSFIDKKPFCFSKKGIEKFLRTELKFSGLIITDDMAMKALKTDGRTTADNVLLALDAGCDMVMCSEPKFKELVEAISKKMKNEPDFLKRIDDAVFNILKTKIKMGIIDESLKPIEKYKFNKEKFYKAKKAAEDILKKSNEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NG5</accession>
    <name>Q73NG5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956922.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1187"/>
    <dbReference type="EnsemblBacteria" id="AAS11706">
        <property type="protein sequence ID" value="AAS11706"/>
        <property type="gene ID" value="TDE_1187"/>
    </dbReference>
    <dbReference type="GeneID" id="2740084"/>
    <dbReference type="KEGG" id="tde:TDE_1187"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1143"/>
    <dbReference type="eggNOG" id="COG3291">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070568_0_0_12"/>
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    <dbReference type="OrthoDB" id="1322409at2"/>
    <dbReference type="Proteomes" id="UP000008212">
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    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004286010" evidence="1">
        <location>
            <begin position="24"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="305" mass="35596" checksum="35887B0A98895105" modified="2004-07-05" version="1">MKFKYKKLYLFFLSCIFAGMLFAQEQGSKIRFQDQDFILGITIDDSWYETVKLEAVVNALKNMKTKPTVRIVMSKDESVSMYIPIFEEIGKVAYILACPVDSYDMKYYKTVYSYKKRFKTAYEVLGKYTDMWEIGNEINGEDWLGKNPKLIADKVAAAYDFIKSKEGITVVTAYAFAPGMQKIEMIDWLKTYLPPRIKNNVDYLLVSYYEDDNEGFQPDWGKIFAVLESIFPNSKLGIGECGSTDENADEKTKLNMIRHYYGMPKYTKNFIGGYFWWYWVQDCVPHENNVLWEEIDSQAAKKRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NJ7</accession>
    <name>Q73NJ7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971763.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956902.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1155"/>
    <dbReference type="EnsemblBacteria" id="AAS11644">
        <property type="protein sequence ID" value="AAS11644"/>
        <property type="gene ID" value="TDE_1155"/>
    </dbReference>
    <dbReference type="GeneID" id="2741487"/>
    <dbReference type="KEGG" id="tde:TDE_1155"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1114"/>
    <dbReference type="eggNOG" id="ENOG5031DHJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2319269_0_0_12"/>
    <dbReference type="OrthoDB" id="2145118at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="99" mass="11266" checksum="83A93C7F8E04245E" modified="2004-07-05" version="1">MSNETDTRNKINEIMEAMEDLLLYKNRLYGNSALNPKQIFYKGDAVNSILIRLDDKLGRIMANTDEKPRINDVADIIGYCTLLLISMGVDKADIDNLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NK0</accession>
    <name>Q73NK0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Head-to-tail joining protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971760.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956899.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1152"/>
    <dbReference type="EnsemblBacteria" id="AAS11641">
        <property type="protein sequence ID" value="AAS11641"/>
        <property type="gene ID" value="TDE_1152"/>
    </dbReference>
    <dbReference type="GeneID" id="2741484"/>
    <dbReference type="KEGG" id="tde:TDE_1152"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1111"/>
    <dbReference type="eggNOG" id="ENOG502Z7XJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035407_0_0_12"/>
    <dbReference type="OMA" id="SGFDEFP"/>
    <dbReference type="OrthoDB" id="1249386at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020991">
        <property type="entry name" value="Connector_podovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12236">
        <property type="entry name" value="Head-tail_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="493"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="560" mass="63841" checksum="E1BDAACEBD101620" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NS8</accession>
    <name>Q73NS8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1074</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971682.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682384.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1074"/>
    <dbReference type="TCDB" id="3.A.1.5.47">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11563">
        <property type="protein sequence ID" value="AAS11563"/>
        <property type="gene ID" value="TDE_1074"/>
    </dbReference>
    <dbReference type="GeneID" id="2739086"/>
    <dbReference type="KEGG" id="tde:TDE_1074"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1034"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_10_0_12"/>
    <dbReference type="OMA" id="IKEQTYV"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="BRENDA" id="7.4.2.9">
        <property type="organism ID" value="6426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="259"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="464" mass="51598" checksum="5CFDA2081045E36D" modified="2004-07-05" version="1">MENFVDRFKEFWNDFKKEKIGIVAIVLLGLLVILIILEPVVLPFKGTNDNWHNISYWEDNPASAPPVWSELFSTKKSARTVRFTEPEITEEESEHFGQAKVYSFKYNYNYDKNPNNIIFRAELTGDVIMSMDVIRPDGKRIELGVFQKGNLKDYHSRFTVLTDAKSTMQQFTAAYGASATSGNANPVQLLFSEVSKTMYRDKKPLKGEYVFKFVIPKDVASNSANKIENPRLIIPGAVSGLLGTDLNKRDLFSGVMAGLKWALLIGLVASIISVLVGVMYGIISAYFGGRVDTVMMFIFEIVVSVPIIPILIVSAAVFKPSIWMIILALIIFGWTGSVKTVRSMALQIKEETYIEAAKALGAGKWRIILKHIAPLLLPYSFAIMASSVPGAIIFESSLSLLGLGDPSIVTWGQILHDAQSSGATLNGLWWWIIPPGLFIALLGMIFAFLGFAMDKILHPKLRTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NV5</accession>
    <name>RS12_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpsL</name>
        <name type="ordered locus">TDE_1047</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971655.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670535.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NV5"/>
    <dbReference type="SMR" id="Q73NV5"/>
    <dbReference type="STRING" id="243275.TDE_1047"/>
    <dbReference type="PRIDE" id="Q73NV5"/>
    <dbReference type="EnsemblBacteria" id="AAS11536">
        <property type="protein sequence ID" value="AAS11536"/>
        <property type="gene ID" value="TDE_1047"/>
    </dbReference>
    <dbReference type="GeneID" id="2741321"/>
    <dbReference type="KEGG" id="tde:TDE_1047"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1007"/>
    <dbReference type="eggNOG" id="COG0048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_1_2_12"/>
    <dbReference type="OMA" id="SPALEKC"/>
    <dbReference type="OrthoDB" id="1707228at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000146345" description="30S ribosomal protein S12">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-methylthioaspartic acid" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="124" mass="13559" checksum="C7DB056709E7B392" modified="2004-07-05" version="1">MPTINQLIKKGRKSAAVKTKSPALQSCPQKRGVCTSVKTITPKKPNSALRKVARIRLSNGIEVTAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIIRGTKDALGVEDRKRGRSKYGAKRPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NX4</accession>
    <name>Q73NX4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971636.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1028"/>
    <dbReference type="EnsemblBacteria" id="AAS11517">
        <property type="protein sequence ID" value="AAS11517"/>
        <property type="gene ID" value="TDE_1028"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1028"/>
    <dbReference type="HOGENOM" id="CLU_3206547_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="45" mass="5290" checksum="EBEA2FC42EEED3EB" modified="2004-07-05" version="1">MSKTASFLIAWHINCLYISDSLKSRLTEPLIELEIVTYKQEVLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NY9</accession>
    <name>Q73NY9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971620.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682325.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1011"/>
    <dbReference type="EnsemblBacteria" id="AAS11501">
        <property type="protein sequence ID" value="AAS11501"/>
        <property type="gene ID" value="TDE_1011"/>
    </dbReference>
    <dbReference type="GeneID" id="2740991"/>
    <dbReference type="KEGG" id="tde:TDE_1011"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.971"/>
    <dbReference type="eggNOG" id="COG1452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280171_0_0_12"/>
    <dbReference type="OMA" id="TSKIPEP"/>
    <dbReference type="OrthoDB" id="236451at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285873" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1073" mass="122497" checksum="700DA6F01B8AC93C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NZ6</accession>
    <name>Q73NZ6_TREDE</name>
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        <recommendedName>
            <fullName evidence="5">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the core of the flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Periplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Periplasmic flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the bacterial flagellin family.</text>
    </comment>
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        <property type="protein sequence ID" value="AAS11494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="RefSeq" id="WP_002670454.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1004"/>
    <dbReference type="EnsemblBacteria" id="AAS11494">
        <property type="protein sequence ID" value="AAS11494"/>
        <property type="gene ID" value="TDE_1004"/>
    </dbReference>
    <dbReference type="GeneID" id="2740984"/>
    <dbReference type="KEGG" id="tde:TDE_1004"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.964"/>
    <dbReference type="eggNOG" id="COG1344">
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
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        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <end position="139"/>
        </location>
    </feature>
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        <location>
            <begin position="201"/>
            <end position="285"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="286" mass="31565" checksum="DBFA3245806885F3" modified="2004-07-05" version="1">MIINHNMSAMFSQRTLGHTHLLNQKNIEKLSSGLRINRAGDDASGLAVSEKMRSQIRGLNQASANAQNGISFIQVAEAFLQETTDVIQRIRELSIQSSNGIYSAEDRLYIQVEVSQLIAEVDRIASHAQFNGMNMLTGRFAQETGENTVTASMWFHIGANMDQRTRAYIGTMTAKALGVRNIGDESIMTIETPEKANRAIGTLDEAIKKINKQRADLGAYQNRLELTVVGINIAAENLQASESRIRDVDMAKEMVDYTKNQILTQSGTAMLAQANQATQSVMTLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P05</accession>
    <name>Q73P05_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11485">
        <property type="protein sequence ID" value="AAS11485"/>
        <property type="gene ID" value="TDE_0995"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0995"/>
    <dbReference type="HOGENOM" id="CLU_3223404_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="44" mass="5308" checksum="DC46EC2BE7E973C5" modified="2004-07-05" version="1">MIVKMNTRKISFIHLNSLFFARQYIVYHIFTKKGSFLAIFIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P35</accession>
    <name>Q73P35_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971574.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682274.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0964"/>
    <dbReference type="EnsemblBacteria" id="AAS11455">
        <property type="protein sequence ID" value="AAS11455"/>
        <property type="gene ID" value="TDE_0964"/>
    </dbReference>
    <dbReference type="GeneID" id="2740772"/>
    <dbReference type="KEGG" id="tde:TDE_0964"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.928"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_277976_0_0_12"/>
    <dbReference type="OrthoDB" id="268143at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284982" evidence="1">
        <location>
            <begin position="20"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1139" mass="130341" checksum="50C883805D3FF574" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P42</accession>
    <name>Q73P42_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971567.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682266.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0957"/>
    <dbReference type="EnsemblBacteria" id="AAS11448">
        <property type="protein sequence ID" value="AAS11448"/>
        <property type="gene ID" value="TDE_0957"/>
    </dbReference>
    <dbReference type="GeneID" id="2740765"/>
    <dbReference type="KEGG" id="tde:TDE_0957"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.921"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_5_12"/>
    <dbReference type="OMA" id="FTDQINP"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="247" mass="27853" checksum="B4E370894331C18D" modified="2004-07-05" version="1">MRKVLNFAHRGFRSKYPENTMLAFSKAVELGVDGIEFDVHLSSDGVPVIIHDEALDRTCNASGLVKDFSFADLKKINAAANFKSSEAASGIKHLDEKIPSLEEYFDFIKNKDIISNIELKTGVFEYPGIEKKVYALLKKYNLQDKCIISSFNHESVLRMKKIDSSLVCGFLVDSWDLHPAAYLKKYGVECYHPPAYRLTKEFVDELHNEGLRVNAWFGSIQTDYAQVLSTGLDSIITDYPDKIAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P46</accession>
    <name>Q73P46_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971563.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682259.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0953"/>
    <dbReference type="EnsemblBacteria" id="AAS11444">
        <property type="protein sequence ID" value="AAS11444"/>
        <property type="gene ID" value="TDE_0953"/>
    </dbReference>
    <dbReference type="GeneID" id="2740761"/>
    <dbReference type="KEGG" id="tde:TDE_0953"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.917"/>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_3_12"/>
    <dbReference type="OMA" id="VYFGAFF"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="354" mass="38490" checksum="BB76F8447900429E" modified="2004-07-05" version="1">MRRYKFLSSVAAFFLGTLVIIIFISLGSQNPKEALSEFFLKPFSSVWYFGNMLNKTSLLLFAASGSLFAFKCGCFNLGGEGQIYFAGLLTGILLQNTWTEPVIQLALTGLIVFFASGLIGLVSGFLKIKFNADELLTSFLISAAILPVVNYLIGNPLRDTSGNLLALPPIAEIFELKSFLPPSSLNISFVFSIILVLFFILFFTKTKWGYRLRLSGTAPEFSKFAGFSVYAPPLAGMGISAGLHGLTGFFAITGTWYICHLSFSSGMGWAALAIALIAKNSFFAIIPAAFLYSWIQSASDAAVMSGSLVFDTAVFLQAVVFLFISANLLSLRFTLGLSKDISRIKTLLLKRKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PC4</accession>
    <name>Q73PC4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluB</name>
        <name evidence="5" type="ordered locus">TDE_0875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971485.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682155.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0875"/>
    <dbReference type="EnsemblBacteria" id="AAS11366">
        <property type="protein sequence ID" value="AAS11366"/>
        <property type="gene ID" value="TDE_0875"/>
    </dbReference>
    <dbReference type="GeneID" id="2740922"/>
    <dbReference type="KEGG" id="tde:TDE_0875"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.845"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_12"/>
    <dbReference type="OMA" id="HVPKTYE"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="234" mass="26567" checksum="E4C20411EE94FC37" modified="2004-07-05" version="1">MIDEIRLQVYLARCGVASRRASENLILNGRVSVDGKIITELGIKVSGKEKICLDGKQIFPEAEKRYILLNKPEGYVCSLADEKDRPIAASLLKDTYTERLYNIGRLDMLSGGAILFTNDGDFSAKVEHPSSEIEKEYEVITVFEYPDEILQKFLRGVRIEGVFYKALSAERISKNKMRIVLIEGKNREIRRVLKFFNIKIKKLTRVRIGCVYLADLPSGKHRPLTSEEIKGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PC9</accession>
    <name>Q73PC9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphatase/nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19621"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:66949"/>
            <dbReference type="ChEBI" id="CHEBI:66954"/>
            <dbReference type="EC" id="3.1.4.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 3'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10144"/>
            <dbReference type="ChEBI" id="CHEBI:13197"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.1.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971480.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682151.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0870"/>
    <dbReference type="EnsemblBacteria" id="AAS11361">
        <property type="protein sequence ID" value="AAS11361"/>
        <property type="gene ID" value="TDE_0870"/>
    </dbReference>
    <dbReference type="GeneID" id="2740917"/>
    <dbReference type="KEGG" id="tde:TDE_0870"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.840"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_4_4_12"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008663">
        <property type="term" value="F:2',3'-cyclic-nucleotide 2'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07410">
        <property type="entry name" value="MPP_CpdB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041827">
        <property type="entry name" value="CpdB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="8">
        <location>
            <begin position="67"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="9">
        <location>
            <begin position="389"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="632" mass="71489" checksum="EBC6B4187257E1E5" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PK8</accession>
    <name>RPOA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="1">RNAP subunit alpha</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoA</name>
        <name type="ordered locus">TDE_0791</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971401.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682041.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PK8"/>
    <dbReference type="SMR" id="Q73PK8"/>
    <dbReference type="STRING" id="243275.TDE_0791"/>
    <dbReference type="EnsemblBacteria" id="AAS11282">
        <property type="protein sequence ID" value="AAS11282"/>
        <property type="gene ID" value="TDE_0791"/>
    </dbReference>
    <dbReference type="GeneID" id="2740669"/>
    <dbReference type="KEGG" id="tde:TDE_0791"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.764"/>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053084_0_1_12"/>
    <dbReference type="OMA" id="LMKFRNF"/>
    <dbReference type="OrthoDB" id="662686at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000175411" description="DNA-directed RNA polymerase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="1">
        <location>
            <begin position="262"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <sequence length="351" mass="39289" checksum="6D8667149B84DCBD" modified="2004-07-05" version="1">MARKNLLKGFKKPKGLEFAQQESTESYGKFTASPFETGFGTTIGNCLRRILLSSIQGYAISAVLITSHDADGVPHTISSEFENIPNVSEDTLEILNKLKQIRLRLSDESEQGDFHFEFKGPASITSKDFAVEGQLEILGEPFYVMELMKGANVSFDVQVDFGRGYVPAEVNEKYIEIVGTIPMDAIYGPVLKVSYAIEPCRVGQRNDYDKLILEIWTDSTVRPEDVLGEAAKIAKDHFSIFINFNENDYLGEDEDDNEEAVIKQLLATSINTLDFSVRAKNCLDSAGIKTLGELAQKSEDEIESMRNVGRMTLNEIHAKLAEYNLRLGMTDYSHLKNTIKVSRQKEETDEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PL9</accession>
    <name>RS14Z_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsZ</name>
        <name evidence="1" type="synonym">rpsN</name>
        <name type="ordered locus">TDE_0780</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971390.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670020.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PL9"/>
    <dbReference type="SMR" id="Q73PL9"/>
    <dbReference type="STRING" id="243275.TDE_0780"/>
    <dbReference type="EnsemblBacteria" id="AAS11271">
        <property type="protein sequence ID" value="AAS11271"/>
        <property type="gene ID" value="TDE_0780"/>
    </dbReference>
    <dbReference type="GeneID" id="2740658"/>
    <dbReference type="KEGG" id="tde:TDE_0780"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.753"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_3_0_12"/>
    <dbReference type="OMA" id="RAYTRCN"/>
    <dbReference type="OrthoDB" id="2032609at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000269156" description="30S ribosomal protein S14 type Z">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <sequence length="61" mass="7082" checksum="2622A494BA8760F0" modified="2004-07-05" version="1">MATVAKINQANRKAKYPTRQYNRCKVCGRPRGYLRKFKMCRVCFRKLASEGQIPGVTKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PQ5</accession>
    <name>Q73PQ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971353.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0742"/>
    <dbReference type="EnsemblBacteria" id="AAS11234">
        <property type="protein sequence ID" value="AAS11234"/>
        <property type="gene ID" value="TDE_0742"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0742"/>
    <dbReference type="eggNOG" id="ENOG5031DVR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191608_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="61" mass="6684" checksum="232CF799DF1EEEED" modified="2004-07-05" version="1">MMIEKYAECSYKSSQQKNAKSCENYLTQLCVSGKIRSLAASQPRSLAASQPRSLAASQPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PT3</accession>
    <name>Q73PT3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription antitermination protein, NusG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0713</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971325.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681936.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0713"/>
    <dbReference type="EnsemblBacteria" id="AAS11206">
        <property type="protein sequence ID" value="AAS11206"/>
        <property type="gene ID" value="TDE_0713"/>
    </dbReference>
    <dbReference type="GeneID" id="2740620"/>
    <dbReference type="KEGG" id="tde:TDE_0713"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.690"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067287_2_2_12"/>
    <dbReference type="OMA" id="EKWYVIY"/>
    <dbReference type="OrthoDB" id="2027986at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="4">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="175" mass="20270" checksum="DED733E6CEA1CF9C" modified="2004-07-05" version="1">MDYYVVQVSTGKEKNFIEDAEFKNKFDELSYSIVFPQRILKIRKAGKVTEKQLPVFAGYLFIGTDEISKDLYQHLRKCKGFYRFLPNNQEPKFLEGRDFEILNQFISFGGLAKISQVVFDENDRIKVIEGPLSGLEGYIVRVNKRKGRATVCLDMCQTAFSIDLGFEILNKEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PT8</accession>
    <name>Q73PT8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971320.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681932.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0708"/>
    <dbReference type="EnsemblBacteria" id="AAS11201">
        <property type="protein sequence ID" value="AAS11201"/>
        <property type="gene ID" value="TDE_0708"/>
    </dbReference>
    <dbReference type="GeneID" id="2740615"/>
    <dbReference type="KEGG" id="tde:TDE_0708"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.686"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_0_12"/>
    <dbReference type="OMA" id="WEEDCSA"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="72"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="171" mass="19466" checksum="E71D56EC4866602C" modified="2004-07-05" version="1">MNEVIKNMLTRVSVRKFTAERVEDEKLKTIVECAKASPTGKNRQMRKFTVVHNREKIQELAKAVSSVLDIPNYRIYDCDALILISFEEDDRFGYCDSSVAIENIYLAAHALGLGSVWINQLREKCNSPEIRRVLDSFNIPKNHVVCGISAIGYPAEHPEPKTRTEPVEFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PU0</accession>
    <name>Q73PU0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="2">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971318.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681927.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0706"/>
    <dbReference type="REBASE" id="6420">
        <property type="entry name" value="M.TdeV"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11199">
        <property type="protein sequence ID" value="AAS11199"/>
        <property type="gene ID" value="TDE_0706"/>
    </dbReference>
    <dbReference type="GeneID" id="2739828"/>
    <dbReference type="KEGG" id="tde:TDE_0706"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.684"/>
    <dbReference type="eggNOG" id="COG3392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034356_0_0_12"/>
    <dbReference type="OMA" id="IFCDLFA"/>
    <dbReference type="OrthoDB" id="1206955at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="303"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="370" mass="42606" checksum="C58130A2F73F7BA1" modified="2004-07-05" version="1">MKEQREENKDFLTTQIITYLGNKRSLIDKIEEEVKLISKYLNKEKLICADIFSGSGIVARMLKKYASKIIVNDLENYSYVINSCYLTNKEEYPKKLCNELRDEIISSSLNKKIPGIISENYAPKDDNKIEKGERVFYTRKNALLIDTYRNLIDKIVREENLKKFFFAPLITEASIHVNTSGVFKGFYKDKNTGVGCFGASGKNALTRILGKVELKEPVFSNFNSELEIFTKDAVILSKEIKNVDIAYIDPPYNQHPYGSNYFMLNLILKNRLDVPISPVSGITQGWNRSVFNKPYLALKSMEEIISSLDACYAVISYNSEGFISFEEMTNMLQKYGELKTVEIKYNTFRGSRNLNKRNIHVSEYLFVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PU8</accession>
    <name>Q73PU8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971310.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669943.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0698"/>
    <dbReference type="DNASU" id="2739820"/>
    <dbReference type="EnsemblBacteria" id="AAS11191">
        <property type="protein sequence ID" value="AAS11191"/>
        <property type="gene ID" value="TDE_0698"/>
    </dbReference>
    <dbReference type="GeneID" id="2739820"/>
    <dbReference type="KEGG" id="tde:TDE_0698"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.677"/>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124456_3_0_12"/>
    <dbReference type="OMA" id="EACITAS"/>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13470">
        <property type="entry name" value="PIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="137" mass="15299" checksum="EF10097124E49ABF" modified="2004-07-05" version="1">MKVLIDTNVILDVLLNRASFVQDAIAVLELTCGNIQAYVSASAITDIYYIAYKELRDKIRVKNLIKTLLQIITVAGISDKEIMSAIDSDWADFEDSLQNAVAESHDCSMIITRNISDFNGSNLQIISPKDFIVQFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PZ7</accession>
    <name>Q73PZ7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cheR</name>
        <name evidence="7" type="ordered locus">TDE_0647</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971261.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669892.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0647"/>
    <dbReference type="EnsemblBacteria" id="AAS11142">
        <property type="protein sequence ID" value="AAS11142"/>
        <property type="gene ID" value="TDE_0647"/>
    </dbReference>
    <dbReference type="GeneID" id="2740478"/>
    <dbReference type="KEGG" id="tde:TDE_0647"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.626"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_1_1_12"/>
    <dbReference type="OMA" id="PGIIYKA"/>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026024">
        <property type="entry name" value="Chemotaxis_MeTrfase_CheR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000410">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="271" mass="31724" checksum="4E50C9CC33AC8A6B" modified="2004-07-05" version="1">MADFLTDQEFRMFSDLIYTASGITFSDTNRSILESRLKEKLRDKKLEKVSDYYAMLMKDSEEQKSLLDSVTTNLTRFFRNQPHFDALENYVIPELVKVKKAEGKNKLKIWSAGCSTGEEPYTIAMVMKKHLPIGFTAEITASDLSLKCLLVGKTGFYQESRVTGIPEDYLKLYFDKLNDGYQVKKDIMQMVNFDYHNLKHDSKHTDFDLVFCRNVLIYFDEPVQKEVIDRFWRAMSPKSFLFIGHSESLFGMETQFKFLKTDWACFYQKGF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-21" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q01</accession>
    <name>PTH_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name type="ordered locus">TDE_0643</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971257.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672368.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73Q01"/>
    <dbReference type="SMR" id="Q73Q01"/>
    <dbReference type="STRING" id="243275.TDE_0643"/>
    <dbReference type="EnsemblBacteria" id="AAS11138">
        <property type="protein sequence ID" value="AAS11138"/>
        <property type="gene ID" value="TDE_0643"/>
    </dbReference>
    <dbReference type="GeneID" id="2740474"/>
    <dbReference type="KEGG" id="tde:TDE_0643"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.622"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_4_2_12"/>
    <dbReference type="OMA" id="HVLSKFH"/>
    <dbReference type="OrthoDB" id="1676462at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000187845" description="Peptidyl-tRNA hydrolase">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <sequence length="203" mass="22446" checksum="BFB56A1C6EF2E329" modified="2004-07-05" version="1">MIDLIVFLGNYGKKYENTRHNAAWVLCDSIEIGSNAVWQSKFKGQYAKLPSSMTPGRAVHLLKPETYMNLSGESVIAAASFFRLKPENILIVHDELELKPGILSFKWSGGLGGHNGLRSIKSVLNTADFFRLRIGIGRPDFSSQGGDASPDISGYVLSRFAQSELDVLKSQVPQADSFFKELLEADEPQTLIKKWAKVLPSQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q03</accession>
    <name>MURA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="1">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murA</name>
        <name type="ordered locus">TDE_0641</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971255.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669886.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73Q03"/>
    <dbReference type="SMR" id="Q73Q03"/>
    <dbReference type="STRING" id="243275.TDE_0641"/>
    <dbReference type="EnsemblBacteria" id="AAS11136">
        <property type="protein sequence ID" value="AAS11136"/>
        <property type="gene ID" value="TDE_0641"/>
    </dbReference>
    <dbReference type="GeneID" id="2740472"/>
    <dbReference type="KEGG" id="tde:TDE_0641"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.619"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_1_12"/>
    <dbReference type="OMA" id="CDPHRAT"/>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000231296" description="UDP-N-acetylglucosamine 1-carboxyvinyltransferase">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <sequence length="426" mass="46246" checksum="27D7A06441544650" modified="2004-07-05" version="1">MHEYIIQGGFPVNGTIKASGNKNAALPCIAAAILSEEPIILKNIPEIEDVFVMLQVFEALGGHYEKIEKNVFKLQIEKVKTSKIPEDLATKIRASILFAGPLLARTGKAVLPPPGGDVIGRRRLDTHFLALTELGARVETDQNFSFIAHKLMGEDIFLDEASVTATENAIMAASLAEGTTIISNAASEPHVQELCKMLNKMGAKISGVGSNILTIEGVKKLNGTEHRIGPDYMEIGSFIGLAAVTRGQLKITDVEPRDMRPLRVAFGKLGIGWSLEGTTLTVPDKQKMQVNCDLGGMIPKIDDAPWPGFPPDLTSIMTVIATQVEGTVLIHEKMFESRMFFVDKLIGMGARITLCDPHRAVISGPSSLHGSELVSPDVRAGMAMVIAACCARGESIIRNVYQIERGYEHLVERLKSIGVKIELKEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q16</accession>
    <name>DNAK_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaK</name>
        <name type="ordered locus">TDE_0628</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971242.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681815.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73Q16"/>
    <dbReference type="SMR" id="Q73Q16"/>
    <dbReference type="STRING" id="243275.TDE_0628"/>
    <dbReference type="EnsemblBacteria" id="AAS11123">
        <property type="protein sequence ID" value="AAS11123"/>
        <property type="gene ID" value="TDE_0628"/>
    </dbReference>
    <dbReference type="GeneID" id="2739353"/>
    <dbReference type="KEGG" id="tde:TDE_0628"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.606"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_12"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000226025" description="Chaperone protein DnaK">
        <location>
            <begin position="1"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="646" mass="69759" checksum="2A61E0B4C74F06C8" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q48</accession>
    <name>Q73Q48_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971210.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681769.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0596"/>
    <dbReference type="EnsemblBacteria" id="AAS11091">
        <property type="protein sequence ID" value="AAS11091"/>
        <property type="gene ID" value="TDE_0596"/>
    </dbReference>
    <dbReference type="GeneID" id="2741559"/>
    <dbReference type="KEGG" id="tde:TDE_0596"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.576"/>
    <dbReference type="eggNOG" id="COG3943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048266_0_0_12"/>
    <dbReference type="OMA" id="TRVECRF"/>
    <dbReference type="OrthoDB" id="1838027at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011204">
        <property type="entry name" value="Virulence_RhuM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13310">
        <property type="entry name" value="Virulence_RhuM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015268">
        <property type="entry name" value="Virulence_RhuM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="342" mass="39454" checksum="2FDFCE280D1BB477" modified="2004-07-05" version="1">MAKDIQVRNSVSDFLIFTKQTGGDGIQVRLHDENIWLTQKSMAQLFDCSIDNIALHLKNIFQTGELDEMATTEDSSVVQKEGERNVSRNMKFYNLDAVISVGYRINSVRATQFRKWATDVLKQFTIKGYVLDKTRLENGQIFDENYFDHLLDEIREIRASERKFYQKITDIYATASDYSPNSIISKTFFATVQNKLHYAIHGSTAAEVIYTRADYQKKNMGLTSWKNSPKGKILKSDVSIAKNYLSETELQDLNQFVSMYLDYAERQAKKKIPMTMEDWAKKLDVFLEFNEEAILTDKGKVSTAIAKSFAESEFEKYRIIQDKTFVSDFDKYLAELENTISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QD1</accession>
    <name>Q73QD1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971126.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956759.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0512"/>
    <dbReference type="EnsemblBacteria" id="AAS11007">
        <property type="protein sequence ID" value="AAS11007"/>
        <property type="gene ID" value="TDE_0512"/>
    </dbReference>
    <dbReference type="GeneID" id="44155126"/>
    <dbReference type="KEGG" id="tde:TDE_0512"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.498"/>
    <dbReference type="HOGENOM" id="CLU_3141864_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="52" mass="6094" checksum="877DD9BE19B3AE4E" modified="2004-07-05" version="1">MKYYEKKSNGDDKILKQDMSQTADRPGMVFMIHLLMEEKCGMPERQRNSGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QE0</accession>
    <name>Q73QE0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2262 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971117.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681628.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0503"/>
    <dbReference type="EnsemblBacteria" id="AAS10998">
        <property type="protein sequence ID" value="AAS10998"/>
        <property type="gene ID" value="TDE_0503"/>
    </dbReference>
    <dbReference type="GeneID" id="2738988"/>
    <dbReference type="KEGG" id="tde:TDE_0503"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.489"/>
    <dbReference type="eggNOG" id="COG4296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084464_1_0_12"/>
    <dbReference type="OrthoDB" id="827870at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019260">
        <property type="entry name" value="DUF2262"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024198">
        <property type="entry name" value="UCP033642"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10020">
        <property type="entry name" value="DUF2262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033642">
        <property type="entry name" value="UCP033642"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2262" evidence="1">
        <location>
            <begin position="143"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="283" mass="32515" checksum="D23CDEC4424E28E6" modified="2004-07-05" version="1">MELIEYMRLRNKMTQKEWEDSFEKKEREIIVLRHEGGGGSLRNGFWDWAAYFLAYVDCETGELHKEEGRIVFPVTDKENLPYQFEDETIYKLKVRAKLPEEVPNGVLPTKKHFLVVEVLEKNAACKELEEILAEYRKPIILQDDILGELIYDKQIKSFQGSIIWQDRKINIILDVDKDNKSGITKAKKALKTMVSEQEKWDAELRSFAAKKLTKLACEWAESDEEAAEITEESFAKRISLSSICMTSGDSFSAYFDDDDLFFGHCITVCGSLKKGIVSADIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QF1</accession>
    <name>Q73QF1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0492</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971106.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681602.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0492"/>
    <dbReference type="EnsemblBacteria" id="AAS10987">
        <property type="protein sequence ID" value="AAS10987"/>
        <property type="gene ID" value="TDE_0492"/>
    </dbReference>
    <dbReference type="GeneID" id="2738977"/>
    <dbReference type="KEGG" id="tde:TDE_0492"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.477"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_12"/>
    <dbReference type="OMA" id="RTWVEPF"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="150"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="369" mass="40871" checksum="277820401159BEB1" modified="2004-07-05" version="1">MNKVLIVEDDEGIADFLRFELEHEGYSVLHAGDGRTALELFESDTPDILLLDIMLPQLNGLEVLRRIRKTSSVPVIMLTARGETFDKVSGLDSGADDYLAKPFEIGASNLDERLPVTDKGDDFDELAKTFNNLLSRLQTDFARERQFTADVSHELKTPLAVILGHANMLRRWGKDDPDRLEHSLSVLIREAHSMQSIIENLLRIARFENGSIKIKAASLSIPALFERLVDETKTYAPGISFDTHIEVETIHTDAELLHQACTIIISNSVKFAGENAHIILSAEYRDSYIISISDNGPGIGEDALPHIFERFYRGDAAHVRSAGGAGLGLSIVKSIMQVLGGSVSAESEERKGAVIIMQLPQNNIYEFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QF8</accession>
    <name>Q73QF8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971099.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681582.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0485"/>
    <dbReference type="EnsemblBacteria" id="AAS10980">
        <property type="protein sequence ID" value="AAS10980"/>
        <property type="gene ID" value="TDE_0485"/>
    </dbReference>
    <dbReference type="GeneID" id="2741390"/>
    <dbReference type="KEGG" id="tde:TDE_0485"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.470"/>
    <dbReference type="eggNOG" id="COG3694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071040_1_0_12"/>
    <dbReference type="OMA" id="KPADAQF"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="261" mass="29978" checksum="940FAD4D772E8ADE" modified="2004-07-05" version="1">MNGLKLYFKYLGILLKSTMQYKASFFLSCLGQFLLTCNSAAALYFLFARFQSIKGFSFGEVIFCYSIMQLSFAITESYARGFDTFSTLIITGDFDRILLRPRNLPLQVLGSKFEFSRIGRLLIAVVLFFYGIRFGNIDWSFLKVLTVFFMLLGGIAVFSGLFLIYAAISFFTIQSLEFMNIFTDGAREFASYPVSIYGNKILRFCTFIIPYALFQYYPLLFLFDKYKNPALAFLPLLSFLFLIPAYLLWRLGVSKYKSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QH8</accession>
    <name>Q73QH8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971079.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681559.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0465"/>
    <dbReference type="EnsemblBacteria" id="AAS10960">
        <property type="protein sequence ID" value="AAS10960"/>
        <property type="gene ID" value="TDE_0465"/>
    </dbReference>
    <dbReference type="GeneID" id="2739219"/>
    <dbReference type="KEGG" id="tde:TDE_0465"/>
    <dbReference type="eggNOG" id="COG3744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129890_0_1_12"/>
    <dbReference type="OMA" id="LPNHHRD"/>
    <dbReference type="OrthoDB" id="1872329at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09872">
        <property type="entry name" value="PIN_Sll0205-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041705">
        <property type="entry name" value="PIN_Sll0205"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="125" mass="14629" checksum="186B9D78EC18150F" modified="2004-07-05" version="1">MYLLDTHTLLWFLRDSPQLSKKALEIITTENKVYVSIASLWEIAIKKSIGKLEFEHSIEKIAELCHEKDILILQIQPKYFDKVIKLPNIHNDPFDRLIISQAIIENLVIITKDTIIPKYSVKTIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QJ1</accession>
    <name>Q73QJ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0452</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971066.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681551.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0452"/>
    <dbReference type="EnsemblBacteria" id="AAS10947">
        <property type="protein sequence ID" value="AAS10947"/>
        <property type="gene ID" value="TDE_0452"/>
    </dbReference>
    <dbReference type="GeneID" id="2740749"/>
    <dbReference type="KEGG" id="tde:TDE_0452"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.439"/>
    <dbReference type="eggNOG" id="ENOG5032YHK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_7_1_12"/>
    <dbReference type="OMA" id="DHEIWYS"/>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="64" mass="7419" checksum="180C770503D6EC67" modified="2004-07-05" version="1">MAQYEKIVREILRKNGCAFVRHGKGDHDIWYSPINDCRFTVDSKIKSRHTANAIMKQSGIAHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QK7</accession>
    <name>Q73QK7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Recombination protein O</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recO</name>
        <name evidence="1" type="ordered locus">TDE_0436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971050.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681503.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0436"/>
    <dbReference type="EnsemblBacteria" id="AAS10931">
        <property type="protein sequence ID" value="AAS10931"/>
        <property type="gene ID" value="TDE_0436"/>
    </dbReference>
    <dbReference type="GeneID" id="2740582"/>
    <dbReference type="KEGG" id="tde:TDE_0436"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.423"/>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090345_0_0_12"/>
    <dbReference type="OMA" id="THGAGHE"/>
    <dbReference type="OrthoDB" id="1758685at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="269" mass="30235" checksum="B5F6C906812F799D" modified="2004-07-05" version="1">MANRSWSSEALVLSLKTFGEGHRNALLLLPYTEHSCQLVDAAVFGGPKSKLRSMVIPYHTGEVWIYSNPIKNSNKISDFKVSDYRIGLSDNLTRIWCAAFAAELAVKLKGNIDWQIINSFLTGIAVSSENECRKALLRFLWRVISLSGLAPDMEHCCRCGIRVSSKMPETDYLNKSVSAFSYAEKNFFFVPHEDSCVCSSCLDKHEPAFPLSGESLLYLFAVQNLIPKISRELNLSDQAYAELKDFLFYLIRLAAGSNFKTLESCDFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QS5</accession>
    <name>Q73QS5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type I restriction-modification system, S subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0368</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970982.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0368"/>
    <dbReference type="REBASE" id="6418">
        <property type="entry name" value="S.TdeVI"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10863">
        <property type="protein sequence ID" value="AAS10863"/>
        <property type="gene ID" value="TDE_0368"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0368"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.358"/>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435936_0_0_12"/>
    <dbReference type="OrthoDB" id="1643879at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="37"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="168"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="562" mass="63639" checksum="BDC2103F221CB33F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QV5</accession>
    <name>Q73QV5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyl-accepting chemotaxis protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970952.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681308.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0338"/>
    <dbReference type="EnsemblBacteria" id="AAS10833">
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        <property type="gene ID" value="TDE_0338"/>
    </dbReference>
    <dbReference type="GeneID" id="2739337"/>
    <dbReference type="KEGG" id="tde:TDE_0338"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.327"/>
    <dbReference type="HOGENOM" id="CLU_1685790_0_0_12"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="155" mass="17314" checksum="5BBB07BC2C6181C5" modified="2004-07-05" version="1">MVDLKKYRNKTRFSILNKLVIFGTLILIAGFTMGGATFYIAKAPIHELTGSIQALKNTMRVLWVLMVVMSILITIVLSLTIVRPIKRKKELSYLSTHFNSTILKIGGSVQLFDTNIAMMQQMGNELASNITETASTINRIQTLAQTESVTETMEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R05</accession>
    <name>Q73R05_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970902.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681229.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0288"/>
    <dbReference type="EnsemblBacteria" id="AAS10783">
        <property type="protein sequence ID" value="AAS10783"/>
        <property type="gene ID" value="TDE_0288"/>
    </dbReference>
    <dbReference type="GeneID" id="2741379"/>
    <dbReference type="KEGG" id="tde:TDE_0288"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.278"/>
    <dbReference type="eggNOG" id="ENOG502ZB5J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075050_1_0_12"/>
    <dbReference type="OMA" id="QIEIQPI"/>
    <dbReference type="OrthoDB" id="947387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025387">
        <property type="entry name" value="DUF4299"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14132">
        <property type="entry name" value="DUF4299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="306" mass="35542" checksum="82530724D305459F" modified="2004-07-05" version="1">MSVSFYINNKKTFFKSKTPMTVKECLGFSSQKIEQFAFDETQNNFDLEKFYNSSVADYECLLCGVYGESSRGFELSFAKEFNQYVVRVFTPSTNEDWQIALTYIKDLARKLGSDIVSERGEHFTVEDIDQFNYTEDILFGIKSYFENKDTDEYISFGIFREVAINHTIVEGFLNSENPIEAFSKFFKDIQYLDAFSANQMFFEDNATKKIIGLYTLTQEVETILPYKPSVEYRNINIVKDEDISSWKLSLVIINGDPDDEESYQGAGDIEYQDFIARLSKDKYRFIDAKYILVDALTQEEILSILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R42</accession>
    <name>Q73R42_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium-dependent transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_0250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970865.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681171.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0250"/>
    <dbReference type="EnsemblBacteria" id="AAS10746">
        <property type="protein sequence ID" value="AAS10746"/>
        <property type="gene ID" value="TDE_0250"/>
    </dbReference>
    <dbReference type="GeneID" id="2739675"/>
    <dbReference type="KEGG" id="tde:TDE_0250"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.245"/>
    <dbReference type="eggNOG" id="COG0733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006855_3_0_12"/>
    <dbReference type="OMA" id="NERGMWN"/>
    <dbReference type="OrthoDB" id="376209at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SSF161070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS10746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="441" mass="47463" checksum="0555A877B661B755" modified="2004-07-05" version="1">MANIESKRDQFNSKWGFILACIGSAVGMGNIWLFPFRVGQFGGAAFLIPYIIFVAVIGYTGVVEEMCFGRAMKTGPHGAFLKATRMRGSEAGNYIGWIPVIGSLGIAIGYTVVVGWIIRFAVGAFTGSMLAAENSGAYFGTIAGPLSSLPWHIIAIAFSFFVMVAGVSAGIEKINKIMMPTFFTLFIILAIRVATLPKALDGYKFLFKTDWSALANIKTWVFALGQAFFSLSLAGSGTVVYGSYLNDSEDARTSAKYTAIFDTLAAMIAALVIIPAVFAYGLEPAAGPPLMFITMPMIFKEMPAGTLFSIIFFIAVLFAGITSLINLYETPVELMQQKFNLSRKAALAIVLGLGFAVGLVVEDGNVLGTWMDVISIYIIPLGALLAGVMFFWVAGKDFVLNEVSKGRLKRVGDSYAIQGKYIYCGLTLIVYILGIFYGGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R69</accession>
    <name>Q73R69_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970838.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666489.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0222"/>
    <dbReference type="EnsemblBacteria" id="AAS10719">
        <property type="protein sequence ID" value="AAS10719"/>
        <property type="gene ID" value="TDE_0222"/>
    </dbReference>
    <dbReference type="GeneID" id="2740776"/>
    <dbReference type="KEGG" id="tde:TDE_0222"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.215"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121411_0_0_12"/>
    <dbReference type="OMA" id="IEIVIKT"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="174" mass="20369" checksum="DDA4E46692ED5FD4" modified="2004-07-05" version="1">MSDTRIINISKIIANDCYEISKSFEEQQWQKPIEQYIQYMDDQNNGLIDVLLAKDNNKFAGYCIIQWKSEYTFFYKNDIPEIKDLNVLKKYQRKGIATALMEEAERRIFYKSNLCGLQVGLTNDYGKAHQLYIKRGYVPDGNGLIYKNINVKYNERVVVDDDLTIALLKAKKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R94</accession>
    <name>Q73R94_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970813.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002684748.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0197"/>
    <dbReference type="EnsemblBacteria" id="AAS10694">
        <property type="protein sequence ID" value="AAS10694"/>
        <property type="gene ID" value="TDE_0197"/>
    </dbReference>
    <dbReference type="GeneID" id="2739013"/>
    <dbReference type="KEGG" id="tde:TDE_0197"/>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_1_2_12"/>
    <dbReference type="OMA" id="YNDIGIT"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="126" mass="14566" checksum="96112ED7F3791D9A" modified="2004-07-05" version="1">MVLVDTSVWIEYFRGNEQVKNLNDLIDSNTLAINDLILTELLPFIIQKKENKLKKLLLNLDRIKMNIDWNGLIQMQTLNLQNGINKVGIPDLIIAQNAIQTNLHLYSLDKHFKLMSSLFGLKLIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RA5</accession>
    <name>Q73RA5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970802.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681074.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0186"/>
    <dbReference type="EnsemblBacteria" id="AAS10683">
        <property type="protein sequence ID" value="AAS10683"/>
        <property type="gene ID" value="TDE_0186"/>
    </dbReference>
    <dbReference type="GeneID" id="2741033"/>
    <dbReference type="KEGG" id="tde:TDE_0186"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.182"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621016_0_0_12"/>
    <dbReference type="OMA" id="KVAMQDP"/>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285920" evidence="1">
        <location>
            <begin position="22"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="441" mass="48989" checksum="4E6A0E613538379A" modified="2004-07-05" version="1">MKKIISVLSIAALLFAISSCGGKSEKNNAVLKVIKEAEGMTLDQLFEKAYQESNGKVLKGLGNSSRGKTAGETFVEAMKAKYPDYTGKIDWSQPKNNTIFDQLTNDNKNVNPEFSMTLIQDGAQIKAKMIDTGILHNFVPKEWKESAGTDMKENGNPLALQTLSKVFMYNNVEASNKFLNVWDFVKEGQSPLFMGLESEPIGKNFLLMLTHEKYSKVVKAAYDALPEADKAYFKPIVDGLEKTAKELGLNENGKYALAWIKLFVSQFNLKTDDGPISVDLVKKSSKDQTGLLVYSKLRSIKETDESSVNNITVAAYQDGYIGFGGYAYKHYLQVLNNAPLPWTACAFIAYMVTTKEGFHPWGKDMGGYSSNPAINQDHSMDGYVEEEVNGEVKKINKFPAKNDRGYDWWTGEGKGGLIVEEPVYCASVTFTVGEWISSLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RJ2</accession>
    <name>Q73RJ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0096</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970713.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676360.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0096"/>
    <dbReference type="EnsemblBacteria" id="AAS10594">
        <property type="protein sequence ID" value="AAS10594"/>
        <property type="gene ID" value="TDE_0096"/>
    </dbReference>
    <dbReference type="GeneID" id="2741711"/>
    <dbReference type="KEGG" id="tde:TDE_0096"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.96"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_0_12"/>
    <dbReference type="OMA" id="ACGIPYW"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="3"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="333"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="444" mass="49002" checksum="437CA304445000AD" modified="2004-07-05" version="1">MSKIVVVGANHAGTSAINFLTELSKENEVVVFDRNTNISFLGCGMALWIGNQIRGSEGLFYSNKEKLEAKGAKVTMEADITRIDFDKKIVYGTVKGSQPIEESYDKLILATGSIPIMPKIKGMDLENVQQVKIFQNAQEVIDKLKNPDIKKIAVVGAGYIGVELAEAFKRHNKEVVLIDAMPSSLSNYYDKPFTDLMDKNLNDHGIKLAYNQLVQEIKGTTKVEAVVTDKGEYPADMVVVCIGFRPNTDLGKDKLETFKNGAYSVNLKQETSIKDVYAIGDCATVFDNSLGEKSYIALATNAVRSGIIAAHNAAGIPLEGIGVQGSNGINIYDLKMVSSGLTVERAKKLGLDVEFTDFEDLQRPEFMEHDNPPVKLRIVYNKKTRVIIGAQMASTYDMSMGIHMFSLAIQEKLTIDKLKLLDIFFLPHFNKPYNYITMAALGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RM2</accession>
    <name>Q73RM2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970683.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680920.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0066"/>
    <dbReference type="EnsemblBacteria" id="AAS10564">
        <property type="protein sequence ID" value="AAS10564"/>
        <property type="gene ID" value="TDE_0066"/>
    </dbReference>
    <dbReference type="GeneID" id="2741681"/>
    <dbReference type="KEGG" id="tde:TDE_0066"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.67"/>
    <dbReference type="eggNOG" id="ENOG5033HN8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094598_1_0_12"/>
    <dbReference type="OMA" id="IRRAFFQ"/>
    <dbReference type="OrthoDB" id="1827957at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285935" evidence="1">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="196" mass="22963" checksum="E2331FFCC4E87E63" modified="2004-07-05" version="1">MKKLFFCIVFILIGFAFSEEAESNKEILKKTETEKKEEKPEFAELPAGYREISLGMNMDAVKEALLKDPIFGYRGERDISLLPGKNRSLIETRGSSNIKRAWFQFYEDNLYIIIIQMDTDKIDYYSMYSALTSKYGEPLSIDPKRSIWKNENVSMILERPLAIKYIDLKVFNELLEKSQTDKAYSDILREEFINDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RS1</accession>
    <name>Q73RS1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10512.1"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0014"/>
    <dbReference type="EnsemblBacteria" id="AAS10512">
        <property type="protein sequence ID" value="AAS10512"/>
        <property type="gene ID" value="TDE_0014"/>
    </dbReference>
    <dbReference type="GeneID" id="2741629"/>
    <dbReference type="KEGG" id="tde:TDE_0014"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.16"/>
    <dbReference type="eggNOG" id="ENOG5034C2R">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_097950_0_0_12"/>
    <dbReference type="OMA" id="YMRFINS"/>
    <dbReference type="OrthoDB" id="1223956at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285055" evidence="1">
        <location>
            <begin position="21"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="205" mass="22929" checksum="CE38C514F7F89693" modified="2004-07-05" version="1">MKRFISCFLIISVFLIPIFAQEEAETPSNSKIDGTAVFRPVRQGDKFIKVGLSLGVPLFNTSAEKFAIKPNIWPGGTINAAFGYYILDGFSLGGTISFQFYPTLAKNLYFAVPITFDMGYTFAVRKWRIPLGGGIGVSVQSYSGNGAQYFGMIFRFDAGTYYQYSPEWSFGGDVSWNVVPQWFKDRTNNRTGNFLGISFAARYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J28</accession>
    <name>Q73J28_TREDE</name>
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        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS13265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="RefSeq" id="WP_002680818.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS13265">
        <property type="protein sequence ID" value="AAS13265"/>
        <property type="gene ID" value="TDE_2748"/>
    </dbReference>
    <dbReference type="GeneID" id="2740715"/>
    <dbReference type="KEGG" id="tde:TDE_2748"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2594"/>
    <dbReference type="eggNOG" id="COG0456">
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    <dbReference type="HOGENOM" id="CLU_142044_0_0_12"/>
    <dbReference type="OMA" id="LWHEDHP"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="152" mass="17753" checksum="1B58016406839904" modified="2004-07-05" version="1">MIKILKIENKDEKAKIVEEVLTDLPEWFGLPESTKEYINDSKELDLWAAKENDETIGFITLTESSSDCADVHCMGVKKIYHNKGIGTLLFNELKKFASTKYDYIQVKTVDEGHYKEYDQTIAFYKKQGFKKLEVFPTLWDEWNPCLVMIQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J34</accession>
    <name>Q73J34_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Site-specific recombinase, phage integrase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2742"/>
    <dbReference type="EnsemblBacteria" id="AAS13259">
        <property type="protein sequence ID" value="AAS13259"/>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.2588"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_2_12"/>
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    <dbReference type="OrthoDB" id="745068at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
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        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
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        <location>
            <begin position="90"/>
            <end position="264"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS13259.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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    </evidence>
    <sequence length="269" mass="32107" checksum="768071CB1F886522" modified="2004-07-05" version="1">MENGTSFEEYLKKSNLSQNTLTSYLWTVKYYTEHYDSVSKENLLAYKGYLIEFFKPKTVNLRIQGINKYLQFIHKDQLQLKFVKVQQKNFLENVISNADYQFLKSSLKRDENREWYFVVWFLAATGARVSELIQIKVEHVKLGYFDLYSKGGKLRRLYIPKILKEEALQWLESIGRDSGYLFLNRFEKHITTRGIAQQLKNYARKYGINEKVVYPHSFRHRYAKNFLEKFNDISLLADLMGHESIETTRIYLRRTASEQRELVDSIVTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J45</accession>
    <name>Q73J45_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="13" type="ordered locus">TDE_2731</name>
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    <organism evidence="13 14">
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973329.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2731"/>
    <dbReference type="EnsemblBacteria" id="AAS13248">
        <property type="protein sequence ID" value="AAS13248"/>
        <property type="gene ID" value="TDE_2731"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2731"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2579"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_0_3_12"/>
    <dbReference type="OMA" id="RPWLFAD"/>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="19"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS13248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="333" mass="36489" checksum="640CDB2E75F89F57" modified="2004-07-05" version="1">MLYKPVSIGGLLLSGNIFLAPVAGYSDKAFRSICVDCGADFTYTEMVSSEALVRDSDKTESLIGRAPNEKAYAVQIFGSNPEYMAKTAVIIAEKYSPECIDINSGCPMAKITKNGAGSALMTDIPLLYRIVKAVNDAMAPYKIPVTLKIRSGFTADKLNWKEAASAAIDAGVKMLTLHPRTRSQVYSGKADWNILAELVQFAKPYQIPIFGSGDLFSPEDAKKMLEETGCAGIMFARGAMGNPFIFTQTRELLTNGTYGEISTEQKIRTGFKELIFLCDEKGEEKGCREMRKRFAAYTKGIPDGSRLRQELVQASTIAEYKAIIQSAFNISCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J52</accession>
    <name>Q73J52_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973322.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13241">
        <property type="protein sequence ID" value="AAS13241"/>
        <property type="gene ID" value="TDE_2724"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2724"/>
    <dbReference type="HOGENOM" id="CLU_3391917_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="32" mass="3689" checksum="774C84B1D405C5D5" modified="2004-07-05" version="1">MLLGLLYHLLRKITIGEDSAILTIILNRAYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J94</accession>
    <name>Q73J94_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973279.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667116.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2681"/>
    <dbReference type="EnsemblBacteria" id="AAS13198">
        <property type="protein sequence ID" value="AAS13198"/>
        <property type="gene ID" value="TDE_2681"/>
    </dbReference>
    <dbReference type="GeneID" id="2739268"/>
    <dbReference type="KEGG" id="tde:TDE_2681"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2533"/>
    <dbReference type="HOGENOM" id="CLU_171168_0_0_12"/>
    <dbReference type="OMA" id="MSIQPID"/>
    <dbReference type="OrthoDB" id="2089624at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="112" mass="12477" checksum="CA3F60304BB0C9EF" modified="2004-07-05" version="1">MAIQPIDLQTLYAQMAKVGKQQGAEQQLASMVKDAQQQQNKIDAEKRLSTVQLVDSDSNNNLRINKDGRSPDEENKGGEHPKKQNTAQIEQEPDSEEYIKDPSLGQRVDISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JA6</accession>
    <name>Q73JA6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-alcohol phosphatidyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2669</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973267.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680714.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2669"/>
    <dbReference type="EnsemblBacteria" id="AAS13186">
        <property type="protein sequence ID" value="AAS13186"/>
        <property type="gene ID" value="TDE_2669"/>
    </dbReference>
    <dbReference type="GeneID" id="2741114"/>
    <dbReference type="KEGG" id="tde:TDE_2669"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2521"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064741_0_0_12"/>
    <dbReference type="OMA" id="IPIAHIC"/>
    <dbReference type="OrthoDB" id="1411517at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="260" mass="30687" checksum="3E799E5F2EBFB08C" modified="2004-07-05" version="1">MEKKIGRLVLLFWLFQCSAVFAIYKIFNTDTEIFSAFLIHITLWHSLLLFFLILYKGDFINVGTNLILEKVNLANGITLLRISSVPLIAFLLKQNSIEQIKIILAVVLILVFLTDFFDGFIARKFNQETRIGRMLDSMSDYSLLALVSIVYYQLGLLPNWFFYLIFVRLMFQALGMLFFMLLKFPVEIKSTRGGKITIAATMILYSLKMLQFFVPFFYNFKQLFLIGEYSCGFIIFVFLFEKIFIFYEHYKKYRKRDIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JB7</accession>
    <name>Q73JB7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cobyrinic acid a,c-diamide synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973256.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680706.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2658"/>
    <dbReference type="EnsemblBacteria" id="AAS13175">
        <property type="protein sequence ID" value="AAS13175"/>
        <property type="gene ID" value="TDE_2658"/>
    </dbReference>
    <dbReference type="GeneID" id="2741103"/>
    <dbReference type="KEGG" id="tde:TDE_2658"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2512"/>
    <dbReference type="eggNOG" id="COG1797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022752_2_1_12"/>
    <dbReference type="OMA" id="QPFKCGP"/>
    <dbReference type="OrthoDB" id="692368at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="3">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="4">
        <location>
            <begin position="238"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="429" mass="48320" checksum="EB9EBE1502D3C343" modified="2004-07-05" version="1">MKGIMISAPNSNSGKTVITAALLYSLKKEGFDISAFKTGPDQVDRKILEIISGKRAGNLDPFMMGQKGIEFSLNISNSEYALIEGVMGCFDGMGTTSENSSFDTAEKIGSDIVLVYAPQGEMFTLIPKLKGMIEFSKNRIRGIILNKLNPKLFPLYKKMIEDNLKLQVLGFFPKVSEFEIEESGLGLDIDERLKEKKFLDVLYKIVKENIDIQKLLNLFQPLKTDTKIEIKKTNTRTAIAMDEAFNLYYSENIFLLENSTEVNYFSPFKDTELPDCNFLYLGSGQINKYKDALSQNIKIKTAIKKFAEAGGKILAEGEGLSYLFEDLDGFKMCGIFQGSVESTSTLQNFGYKQLEFMQDCILGKKGTLLNAAEYHKSKATTKLSPIFTVKKPYANISFKDAYVYKNCLGLFQNIHFIYNIENLYNLIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JD0</accession>
    <name>Q73JD0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973243.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680676.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2645"/>
    <dbReference type="DNASU" id="2741090"/>
    <dbReference type="EnsemblBacteria" id="AAS13162">
        <property type="protein sequence ID" value="AAS13162"/>
        <property type="gene ID" value="TDE_2645"/>
    </dbReference>
    <dbReference type="GeneID" id="2741090"/>
    <dbReference type="KEGG" id="tde:TDE_2645"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2500"/>
    <dbReference type="eggNOG" id="COG3862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148086_0_0_12"/>
    <dbReference type="OMA" id="PRGKEWA"/>
    <dbReference type="OrthoDB" id="1751763at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036593">
        <property type="entry name" value="CPE0013-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012460">
        <property type="entry name" value="DUF1667"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39450">
        <property type="entry name" value="PTHR39450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07892">
        <property type="entry name" value="DUF1667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160148">
        <property type="entry name" value="SSF160148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="130" mass="14137" checksum="DB5858CF9F8AA72A" modified="2004-07-05" version="1">MSRELIKEKFTCVSCPRGCKLSVFKEESGEITVTGNLCKGGELYAMQEIKDPRRNISSTVIIEGGVIPSLPVKTSSPIPKALIFDVMKEINTVKTQAPKKMGDVIIENVLNTGIDIVASRSVRVKNGKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JD9</accession>
    <name>Q73JD9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2636"/>
    <dbReference type="EnsemblBacteria" id="AAS13153">
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        <property type="gene ID" value="TDE_2636"/>
    </dbReference>
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    <dbReference type="KEGG" id="tde:TDE_2636"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2492"/>
    <dbReference type="eggNOG" id="ENOG5032SYW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1331389_0_0_12"/>
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    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="199" mass="22104" checksum="4274DC467722DF76" modified="2004-07-05" version="1">MDNETKQEFGEIAQNIAPYGIIMAVFTLCYSVWFCFAWGTVGLILFALTVIYGAYIAFASIKNIKHAKRFKVVPSEAGKKIVKKMSIVSAITYSAVTVFAATLSAVHLVKLIFPAVTLIIGLHFIPLGKIMNRKIDYFIAPVPIVFSLAASYLAFTTTMTWLEVYAVAGIGGAFATMIYGAYMLYAYKKVVREYRIEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JI9</accession>
    <name>Q73JI9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973028.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680365.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2429"/>
    <dbReference type="EnsemblBacteria" id="AAS12947">
        <property type="protein sequence ID" value="AAS12947"/>
        <property type="gene ID" value="TDE_2429"/>
    </dbReference>
    <dbReference type="GeneID" id="2739854"/>
    <dbReference type="KEGG" id="tde:TDE_2429"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2296"/>
    <dbReference type="eggNOG" id="ENOG5030VJ4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046708_0_0_12"/>
    <dbReference type="OMA" id="QENITWK"/>
    <dbReference type="OrthoDB" id="2106354at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="469" mass="54774" checksum="3E19C3B2E2B7F239" modified="2004-07-05" version="1">MKKFVLNIIFGLILFSANAEIKMEVGIKEFFDKINPLIEKNQQYKKMELSFKLNEMSLLSEFAGWMPFPYLDVNTSVSGTELDKHYKAFDIAASLGISQRLPLGMSLNLTGKQSCGIFFDNKPDYSYKFSSSAGLNVPLWFMAPSALPDFVKQEFGLYQNKRRLSMLERDKNKKALIIKMISAIGSEKILKKKLELLKNVQNWNIEEKQKNEILFLQGKLSVLDFSEKNKKIRQEEILLFQAEQSYEALIGEIESMGLTFRDLNEDIDSWLDFFENFAFYLQKEASVEDELSLLRHEISWMQSVKNFNNSIPRLFFSFGADVLPSKDRYPSFPAAFMGYWKDNPRLKWSVSMNLRINLSPLHDDFRLNKNFKILKEINSLNETFLRRSLEEEKKKGLKNIEKALFTSEMSKSSLEIQKKYFTLAEELYKQGKSSIHELYAAQNLLEEVKINYYAERFSYILSVLQTYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JQ3</accession>
    <name>Q73JQ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973054.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667505.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2456"/>
    <dbReference type="EnsemblBacteria" id="AAS12973">
        <property type="protein sequence ID" value="AAS12973"/>
        <property type="gene ID" value="TDE_2456"/>
    </dbReference>
    <dbReference type="GeneID" id="2739641"/>
    <dbReference type="KEGG" id="tde:TDE_2456"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2324"/>
    <dbReference type="eggNOG" id="ENOG5033MH4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1786042_0_0_12"/>
    <dbReference type="OrthoDB" id="2215561at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="145" mass="16335" checksum="E0590F2CC2EE7D63" modified="2004-07-05" version="1">MDVYLIIGEYATGKSSLMRCLTGSKQMEVKELKMLKQNVINAYVFVRSAQEKGMQPQDVINEVIQNPQKPNAVVATLRRKAVNKCPDAISYITAFQNAGWNVQKTVLLDFQANSPAYINPYMLSNVNQQPINVPAQQIRTHFAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JS0</accession>
    <name>Q73JS0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973062.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2464"/>
    <dbReference type="EnsemblBacteria" id="AAS12981">
        <property type="protein sequence ID" value="AAS12981"/>
        <property type="gene ID" value="TDE_2464"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2464"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2331"/>
    <dbReference type="HOGENOM" id="CLU_3158994_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="48" mass="5505" checksum="8314544C2D604B1F" modified="2004-07-05" version="1">MEATQIGTSITLPPLIALSEAYKNISFYRLSLNLIYDVFHKSLIYKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JS6</accession>
    <name>Q73JS6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2484"/>
    <dbReference type="EnsemblBacteria" id="AAS13001">
        <property type="protein sequence ID" value="AAS13001"/>
        <property type="gene ID" value="TDE_2484"/>
    </dbReference>
    <dbReference type="GeneID" id="2741457"/>
    <dbReference type="KEGG" id="tde:TDE_2484"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2350"/>
    <dbReference type="eggNOG" id="COG1594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039030_0_0_12"/>
    <dbReference type="OMA" id="WFAPNGL"/>
    <dbReference type="OrthoDB" id="1472466at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="355" mass="39502" checksum="B6E28F800F4C0F1F" modified="2004-07-05" version="1">MSVENYKCPGCGAPISFKPATGGFKCDYCFSSYTEEEITRYMEGLKAKKGGSEGSSSSENKSGNNGSVKQYHCNNCGAEVVAGETSSAAFCYYCHSPVVLSERLRGEFKPDKIIPFKLDKKDALKCFASWVKGKKYVPADFKNTSTQEKMTGVYLPHWQADVVADLDYHAVGLKVSSWKNGNTEYTKTDKYKIERTGKIELDKFQELAFTKIDKNLINGISPYDLENQKDFSQGYLAGFFSEQYDIKKEDVEPIIKGRAEDYAKDLIKDSADYSGGIEDEDDNTSYTVKNYNYVLLPSWILTYLYKGKTYVFAVNGQTGKSSGELPLNKSKLALVSGLISGILAALLLLGGRFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JU3</accession>
    <name>Q73JU3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973090.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957243.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2492"/>
    <dbReference type="EnsemblBacteria" id="AAS13009">
        <property type="protein sequence ID" value="AAS13009"/>
        <property type="gene ID" value="TDE_2492"/>
    </dbReference>
    <dbReference type="GeneID" id="2741465"/>
    <dbReference type="KEGG" id="tde:TDE_2492"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2358"/>
    <dbReference type="eggNOG" id="ENOG50347X1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1015418_0_0_12"/>
    <dbReference type="OMA" id="HEYGVIF"/>
    <dbReference type="OrthoDB" id="905221at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="301" mass="34259" checksum="0C2C9620E797968B" modified="2004-07-05" version="1">MKKRTSFLIWLFILIALGGTAFFFGWMQFSVPAGSYGVMLSKSGGYHDRLIIPGEFMWRWERLVPTNSKILTFNLKAQDIEYKNEGALPSADKFGLVMEQKNDFRWKFALKISASVKPESLISLVKNASIKTQSDLDDFIRTRVEEAAQKSANEFIEYFLSNPEEYEKLKFQYAAFNDKITSDLKNKENTEIEIVSVELSSDFVIPDLKLYTTIRDVYSEYEKARSKVFTDLMIEEGKSAAGSKFRMNDLKEWGELLKQYPQLIDFLAVARSDASETLKALRELKAKMSGAQVSGTQGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JX6</accession>
    <name>Q73JX6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973135.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680504.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2537"/>
    <dbReference type="EnsemblBacteria" id="AAS13054">
        <property type="protein sequence ID" value="AAS13054"/>
        <property type="gene ID" value="TDE_2537"/>
    </dbReference>
    <dbReference type="GeneID" id="2739049"/>
    <dbReference type="KEGG" id="tde:TDE_2537"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2400"/>
    <dbReference type="eggNOG" id="ENOG5031D9J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1577803_0_0_12"/>
    <dbReference type="OrthoDB" id="1878063at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="170" mass="19623" checksum="48D4D045EFB118C4" modified="2004-07-05" version="1">MKQEKDRIVKFFTLKLWLRISAIVIGGAIFYLNISSMKEGEYSIIALIFGTLFLVAGLFENSWYFNITKEQAIQKAGIFFFPKTKIINFSAIHSIEIETFKRPARFGTFTEVKMVLLDGKTIVIDNDKTKFLQKQLEEIAEVQDIIRRQNNKKAEDFFNAVAADILNPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K06</accession>
    <name>Q73K06_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973157.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680532.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2559"/>
    <dbReference type="EnsemblBacteria" id="AAS13076">
        <property type="protein sequence ID" value="AAS13076"/>
        <property type="gene ID" value="TDE_2559"/>
    </dbReference>
    <dbReference type="GeneID" id="2739924"/>
    <dbReference type="KEGG" id="tde:TDE_2559"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2418"/>
    <dbReference type="eggNOG" id="COG4988">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_12"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="354"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="387"/>
            <end position="394"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS13076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="606" mass="67667" checksum="E3467FBF981F0273" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KA8</accession>
    <name>Q73KA8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972911.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2311"/>
    <dbReference type="EnsemblBacteria" id="AAS12830">
        <property type="protein sequence ID" value="AAS12830"/>
        <property type="gene ID" value="TDE_2311"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2311"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2181"/>
    <dbReference type="HOGENOM" id="CLU_3318661_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="39" mass="4703" checksum="90727C68FE396C4E" modified="2004-07-05" version="1">MSSRSTSQMNFLPIYYFFQIIPTNIMGRENMKKLGENKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KB4</accession>
    <name>Q73KB4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972905.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680218.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2305"/>
    <dbReference type="EnsemblBacteria" id="AAS12824">
        <property type="protein sequence ID" value="AAS12824"/>
        <property type="gene ID" value="TDE_2305"/>
    </dbReference>
    <dbReference type="GeneID" id="2740270"/>
    <dbReference type="KEGG" id="tde:TDE_2305"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2175"/>
    <dbReference type="eggNOG" id="ENOG50339QT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128613_1_0_12"/>
    <dbReference type="OMA" id="EEICYLG"/>
    <dbReference type="OrthoDB" id="2035956at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="150" mass="17653" checksum="B8120DEE2DF75D5C" modified="2004-07-05" version="1">MSKRRFKPMRSQRTEKREDDTPQKRPLDGQIKKAKTFQGQNREPAFKKIEYPKYKCTKCGEIIQDLSSAIADKESGLPVHFDCVIEFLKKAEELKEGEEIIYIGNGNFAVAYFENPKVRKNFKIIKLIEWEDKNKLYQWKKDISELTSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KD5</accession>
    <name>Q73KD5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_2283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972883.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680173.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2283"/>
    <dbReference type="EnsemblBacteria" id="AAS12802">
        <property type="protein sequence ID" value="AAS12802"/>
        <property type="gene ID" value="TDE_2283"/>
    </dbReference>
    <dbReference type="GeneID" id="2740033"/>
    <dbReference type="KEGG" id="tde:TDE_2283"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2153"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_12"/>
    <dbReference type="OMA" id="GIMNITF"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="19"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="315"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="412" mass="45169" checksum="5A7FBCAE15FFA903" modified="2004-07-05" version="1">MFEDFINALHNFRTNKMRTLLSLLGIVIGVTSVIIVTSLASSLSNSMIKEFEEFSMDIINIGTQADNPEFAGEGKIIKFDEAFRKKLMQKIPEIKHVFYSNTFQASIIRNDLRIEISDIEGIEAERLESHRVVMDYGSFFSSSDYSTGAEKAIIGERIAFQLFPEGRAVGKFITLQIPSSSEKSPPLIVRLQVIGVVKPKNTWVIRTSDAVFVPRKFALSRLPGKVSEAVWAAEVAISDPKVSSKVEVKIQDFSEELSGGNRFALWVYSARQQFEQMTKITGMVSLVLSAIAGISLLVGGIGIMNIMLVTVTERRREIGIRKALGATGGAIRMQFLIESASLTLTGGLIGIVLGLLISKLIVNVFFPPEIIFLPNFSGSLIAFSVSVCTGIFFGLHPAIKAARLDPVLALAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KE3</accession>
    <name>TRUA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="1">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truA</name>
        <name type="ordered locus">TDE_2275</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972875.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667863.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KE3"/>
    <dbReference type="SMR" id="Q73KE3"/>
    <dbReference type="STRING" id="243275.TDE_2275"/>
    <dbReference type="EnsemblBacteria" id="AAS12794">
        <property type="protein sequence ID" value="AAS12794"/>
        <property type="gene ID" value="TDE_2275"/>
    </dbReference>
    <dbReference type="GeneID" id="2740025"/>
    <dbReference type="KEGG" id="tde:TDE_2275"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2146"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_1_12"/>
    <dbReference type="OMA" id="FLYGMVR"/>
    <dbReference type="OrthoDB" id="1075262at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000057478" description="tRNA pseudouridine synthase A">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <sequence length="268" mass="30277" checksum="A853EF2F2FCBE5EF" modified="2004-07-05" version="1">MEISQNQKNILLTISYDGTNFCGWQKQTKEGAETFRTVQGELEKALTKIHKHPIETNGSGRTDSGVHAARQAVNFFCDIKSMRASNFLPALNSILPKDIRVMDAAEVSPLLHARFNALSRTYRYKIKCGKTIFAHEQPYTWHIRRYPDIAALNEMASCLSGELDCTAFSAAGDQSISKSRYIKKAVFFIENDYLIFEICANAFLWKMVRSIVGTLLHLDEIGASKKDFKDILESKMREKAGPTAPPQGLFLWSIEYPEDLLKAPPETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KE4</accession>
    <name>Q73KE4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972874.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667865.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2274"/>
    <dbReference type="EnsemblBacteria" id="AAS12793">
        <property type="protein sequence ID" value="AAS12793"/>
        <property type="gene ID" value="TDE_2274"/>
    </dbReference>
    <dbReference type="GeneID" id="2740024"/>
    <dbReference type="KEGG" id="tde:TDE_2274"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2145"/>
    <dbReference type="eggNOG" id="COG1655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083032_0_0_12"/>
    <dbReference type="OMA" id="KNPRTCP"/>
    <dbReference type="OrthoDB" id="606787at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018708">
        <property type="entry name" value="DUF2225"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09986">
        <property type="entry name" value="DUF2225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="291" mass="33437" checksum="65548CC179428B8B" modified="2004-07-05" version="1">MIRKQAEKESRTGSITFYSKEQVQCPVCSTKFKREELHSGGGRLIAGDLTDELRRLYEPSAKYGEIFPTVYNLTVCHKCLYTAFPQDFAIPSRPVIEKLFENTEARYEAVKGLFHNVDFTKSRGLNEGAASYYLAILCYELFEEKFSPTIKQAICAIRAAWLFDELGKKYPEENYKYVSDLFYRKATFLYRRALELESTGTEIIAGLKSFGPDVDKNYGYDGIIYLSALLEYKYGQKIDMDMRLKRLDYHKFALAKMFGLGKSSKNKPGPILEAARSLYDTLKVELKDVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KG8</accession>
    <name>Q73KG8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972850.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680113.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2250"/>
    <dbReference type="EnsemblBacteria" id="AAS12769">
        <property type="protein sequence ID" value="AAS12769"/>
        <property type="gene ID" value="TDE_2250"/>
    </dbReference>
    <dbReference type="GeneID" id="2741355"/>
    <dbReference type="KEGG" id="tde:TDE_2250"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2124"/>
    <dbReference type="eggNOG" id="COG2035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055621_2_1_12"/>
    <dbReference type="OMA" id="PIPVWSF"/>
    <dbReference type="OrthoDB" id="1426624at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007163">
        <property type="entry name" value="DUF368"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37308">
        <property type="entry name" value="PTHR37308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04018">
        <property type="entry name" value="DUF368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="253" mass="27325" checksum="C80B346C80163F48" modified="2004-07-05" version="1">MYTKAMLNYIKKIIAGIAIGIANVIPGVSGGTIAVVFGVYSDLIGAASLDIKIIKANFKIYLCLFGGMGLGILLFARLFKLVYEKFPVQTNFFFVGLIVGSIFIIFELVREKEKESSFTKVFKILWFFIGLSIMLALYFFKGAAVSSTAAIETLSLGSFIFLFLAGFAGAAAMIIPGISGSFLLLIMGAYYTVIKAITDFNIPVLIPVGLGVLAGIILSARLIGFFMEKFPKITYAFILGLVAGSIRHMIPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KG9</accession>
    <name>Q73KG9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="8">2.7.8.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mraY</name>
        <name evidence="8" type="ordered locus">TDE_2249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="8"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972849.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680111.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2249"/>
    <dbReference type="EnsemblBacteria" id="AAS12768">
        <property type="protein sequence ID" value="AAS12768"/>
        <property type="gene ID" value="TDE_2249"/>
    </dbReference>
    <dbReference type="GeneID" id="2741354"/>
    <dbReference type="KEGG" id="tde:TDE_2249"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2123"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_857073_0_0_12"/>
    <dbReference type="OMA" id="NTTNCTD"/>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="352" mass="39163" checksum="AC7C2CBC1EBB8D78" modified="2004-07-05" version="1">MLYHIAELLGPYFGPMRLLQSYAVLISLGLFLGFLITVLLLPKFYSKLPKDRGREFTVNPEAAVGKPTGGGVVFISIFVLCVFLLIIPTLTQGLVLVITFAVMLTGFLDDRSEKSWGEYLKGGLDFILSAVTALVIFYIYFEGKVSFWLPFISNLVEVHPIVFFVVSIMILWISINTTNCTDGVDGLSGTLILLALVSLGIVFYFVLGHVKVAAYLLVPNISTGAKWAVMIFTLCGVLTGYLWHNAYPSKVLMGDAGSRALGFFIGVLVIISRNPFILLMTSCVILINGGTGILKVVMLRFFKIRIFKNIRFPLHDHMKKNLQWSPTQVLIRFVIVQILITIVILGILFKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KH7</accession>
    <name>Q73KH7_TREDE</name>
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        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972841.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2241"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12760">
        <property type="protein sequence ID" value="AAS12760"/>
        <property type="gene ID" value="TDE_2241"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2241"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2115"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_844509_0_0_12"/>
    <dbReference type="OrthoDB" id="1394964at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="34"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="381" mass="42900" checksum="263C58BB199E3F53" modified="2004-07-05" version="1">MKRLLKLESISQNNWAIPATHSSGQLNRPIISLSVPVYGMESFLPALLDSILAQNLLLKNSVQKSGFFSHNKDTLPIEVLIVNDGSPGGDALPKILKPYKKKFKNLGITLTLLEHRKNLGLFEARRTAANAASGSYIFFADPDDTLPSDSLLVFYNGLLASGNGNLSDAADIIHGKMRLSVPQFDTADKKNAEKFDTFSKSVQSIHPGFLSGNEVLENFLIKKEHSGFLCAKLFRTGLLQEVYAELPHIFCIMAEDLLLYFFVLLKKPSYYGIDSFVYNYINDTGISSASQVINLDRWEKICSSASVFTIIFSYIQENPLDEKYVKELRIACNNQLKKIISKMKRDFTDSLQAEAYAILCDYWGEDYVKQIEKNMKDEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KJ4</accession>
    <name>Q73KJ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972824.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2224"/>
    <dbReference type="EnsemblBacteria" id="AAS12743">
        <property type="protein sequence ID" value="AAS12743"/>
        <property type="gene ID" value="TDE_2224"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2224"/>
    <dbReference type="HOGENOM" id="CLU_3259297_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="42" mass="4884" checksum="7DDA5C128835B88D" modified="2004-07-05" version="1">MKKLFSQADSLSALADTMKNFLTEQSRKALIFAAKSFYRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KM5</accession>
    <name>Q73KM5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Threonine synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972793.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680037.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2192"/>
    <dbReference type="EnsemblBacteria" id="AAS12712">
        <property type="protein sequence ID" value="AAS12712"/>
        <property type="gene ID" value="TDE_2192"/>
    </dbReference>
    <dbReference type="GeneID" id="2740214"/>
    <dbReference type="KEGG" id="tde:TDE_2192"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2069"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015170_0_0_12"/>
    <dbReference type="OMA" id="FGRIAFQ"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thr_synth_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="472" mass="52658" checksum="17692141388900BE" modified="2004-07-05" version="1">MKFYDIANKNILVSFKEAVLRGFNSETGGVFMPAELGKISPAMIYRNPPSSFRDICFEIIKNFCGDEIPEDDLMSIIAQFYPHRLPINPIAPTTYVLELFHGPTCNYKDIGSGFLAYLLEYFNKDEDGDINLIVPASGERACAIASAVSQVKRVNALLLYPKDSLTEIQENFLSSMPKNVYPICVEGSFEDCENLVDKALKDEDLLKKLKLVSGGALNIAPLLPQVAFFVYAALTVLYRSDYDNKIENPSIITSIPSGSFSALTAALIAKKMGTPIKGLISTENENHALSDWLTAGDLKKRTAIKTNTPALDIPNTINFKRMLQIYDVEELRRLIIPYWLDGMGTISSVRTCNERTGYIIDPYGAMAWTAWQDVYNGALNSLKRKTSENDEDPGIPLKYANIETWASAIHRSSMVGIVLQTSHPAKFPEIMKPAIGRPPSLPDKLESLQYRLLKAVNILPDYSMFKEWALSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KM6</accession>
    <name>Q73KM6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyrimidine-nucleoside phosphorylase</fullName>
            <ecNumber evidence="6">2.4.2.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pdp</name>
        <name evidence="6" type="ordered locus">TDE_2191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.2" evidence="6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972792.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680036.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2191"/>
    <dbReference type="EnsemblBacteria" id="AAS12711">
        <property type="protein sequence ID" value="AAS12711"/>
        <property type="gene ID" value="TDE_2191"/>
    </dbReference>
    <dbReference type="GeneID" id="2740213"/>
    <dbReference type="KEGG" id="tde:TDE_2191"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2068"/>
    <dbReference type="eggNOG" id="COG0213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025040_0_1_12"/>
    <dbReference type="OMA" id="DVWRRMI"/>
    <dbReference type="OrthoDB" id="1724909at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="5">
        <location>
            <begin position="350"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="443" mass="47861" checksum="7767B675316082A3" modified="2004-07-05" version="1">MRATDIIMKKRGIKGQAIEPLNRKEIEFIVNSYVRGEIPEYQISAWLMAVYFNGMTFEETAILTDVMLHSGKVMDLSSLEGPFVDKHSTGGVGDKLSLPLAPIVAANGVKVPMMSGRALGHTGGTLDKLEAVTGYRTNLTEAEFRNFIEKTGFAMTGQTKEIVPADRLLYAMRDVTATVESVPLITSSILSKKVAEGSEALVFDVKCGKGAFMKTLSDAKALAVSLVGTAKAMGKKARALITNMNEPLGTMAGNFLEIEETIDILKGQGPADSTELTLQLAAHMLVLGGKAKTEEEGLSLAKEAVSSGKALDLFIKNIELQGGNPKTLMAEYKTRRSKFFEELKAERDGFIESINAFEVGMAGVNLGVGRNKTTDPVCPDAGVEILKHKGDSVKKGDLIMRVYGKDSASVSASMPLLKNAIEYSDKAPQKNKLIFKIIKQEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KS4</accession>
    <name>Q73KS4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TDE_2143</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972744.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957163.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2143"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12663">
        <property type="protein sequence ID" value="AAS12663"/>
        <property type="gene ID" value="TDE_2143"/>
    </dbReference>
    <dbReference type="GeneID" id="2739129"/>
    <dbReference type="KEGG" id="tde:TDE_2143"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2024"/>
    <dbReference type="eggNOG" id="COG4953">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_7_2_12"/>
    <dbReference type="OMA" id="APENFDM"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011815">
        <property type="entry name" value="PBP_1c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009647">
        <property type="entry name" value="PBP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06832">
        <property type="entry name" value="BiPBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02073">
        <property type="entry name" value="PBP_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="10">
        <location>
            <begin position="67"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="9">
        <location>
            <begin position="304"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="BiPBP_C" evidence="11">
        <location>
            <begin position="666"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS12663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="765" mass="85981" checksum="ADBBA9736E7A0930" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-21" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KT5</accession>
    <name>Y2132_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>Putative ABC transporter ATP-binding protein TDE_2132</fullName>
            <ecNumber>7.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_2132</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972733.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675584.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KT5"/>
    <dbReference type="SMR" id="Q73KT5"/>
    <dbReference type="STRING" id="243275.TDE_2132"/>
    <dbReference type="EnsemblBacteria" id="AAS12652">
        <property type="protein sequence ID" value="AAS12652"/>
        <property type="gene ID" value="TDE_2132"/>
    </dbReference>
    <dbReference type="GeneID" id="2739391"/>
    <dbReference type="KEGG" id="tde:TDE_2132"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2014"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="YALELCP"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000092123" description="Putative ABC transporter ATP-binding protein TDE_2132">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="261" mass="28781" checksum="AE6481826496FFEA" modified="2004-07-05" version="1">MAVLIENLSYTYPDGRNAIKNINAHFEKGKKTAVVGLNGSGKSTLLYHLNGTILPQTGRVNILGEEVSKKTLNSVRKKSGFLFDYPDHQLFLTSVYEDIGFGLKNLGMGRGEIEAAVDRILKKLNIEHLKDYSPYQLSLGQKKICAIAGVLVMEPEIIVCDEPFSGLDSKVKAAFKAILDDFSKEGKTIIFSTHDQDFCYEWADNVYVMNEGELIAGGDAVSIFNNAEVLQRAGIVMPKLARLFGHKNPAPRSVEDALNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KX0</accession>
    <name>Q73KX0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972698.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12617">
        <property type="protein sequence ID" value="AAS12617"/>
        <property type="gene ID" value="TDE_2097"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2097"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1980"/>
    <dbReference type="HOGENOM" id="CLU_057504_5_2_12"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="87" mass="10049" checksum="19AC6105C83F8574" modified="2004-07-05" version="1">MKKANTAISVMEMSPRDKWLYDSRMKYEHDRASCISEGYRQGLERGLDKGAYQKALETARLMRMHNYPIAEICTMTGLSKEEVEAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L12</accession>
    <name>Q73L12_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972656.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674683.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2054"/>
    <dbReference type="EnsemblBacteria" id="AAS12567">
        <property type="protein sequence ID" value="AAS12567"/>
        <property type="gene ID" value="TDE_2054"/>
    </dbReference>
    <dbReference type="GeneID" id="2740648"/>
    <dbReference type="KEGG" id="tde:TDE_2054"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1939"/>
    <dbReference type="eggNOG" id="ENOG5032Z13">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148087_1_0_12"/>
    <dbReference type="OMA" id="CMENADA"/>
    <dbReference type="OrthoDB" id="1503929at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285820" evidence="1">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="112" mass="12285" checksum="BF36714B6E5FE7E4" modified="2004-07-05" version="1">MKKRTAIFICFLVLGAALLFAHAPILHCYDNGDGTFTCEGGFTDGSSAEGVEIRIENPKEKDAKKKVIIKTKLDKNGEITIKYADIKVKDFLIIFDAGPGHVVKVKSSDIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L38</accession>
    <name>Q73L38_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972630.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2027"/>
    <dbReference type="EnsemblBacteria" id="AAS12541">
        <property type="protein sequence ID" value="AAS12541"/>
        <property type="gene ID" value="TDE_2027"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2027"/>
    <dbReference type="HOGENOM" id="CLU_2453718_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="89" mass="10579" checksum="F39EB593449D830B" modified="2004-07-05" version="1">MTHISIKKISFCRYIRDKGTSKNFSFSRSFLILICLKGNLSNTLPIKMFYWAVIVAFKGAQYDFFKIRFKSESFFCFMFFYDRIGGFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L48</accession>
    <name>Q73L48_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972620.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679785.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2017"/>
    <dbReference type="EnsemblBacteria" id="AAS12531">
        <property type="protein sequence ID" value="AAS12531"/>
        <property type="gene ID" value="TDE_2017"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2017"/>
    <dbReference type="eggNOG" id="ENOG50324BT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2002886_0_0_12"/>
    <dbReference type="OrthoDB" id="2157026at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="124" mass="15061" checksum="A66D30716B2EBD94" modified="2004-07-05" version="1">MTRSKKYIYMLFIYLSVTYIYLIIYAIINKYKMDDMLFMLRIYSWMLLIHFGMLIFGKKTLFNYIKNTFGLQIFMLVLGFIYLLVYLFIIFNTTGFNRYMWSFVGLGIVSAAFCTFFYLRIIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LI2</accession>
    <name>Q73LI2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972484.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669684.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1881"/>
    <dbReference type="EnsemblBacteria" id="AAS12395">
        <property type="protein sequence ID" value="AAS12395"/>
        <property type="gene ID" value="TDE_1881"/>
    </dbReference>
    <dbReference type="GeneID" id="2739110"/>
    <dbReference type="KEGG" id="tde:TDE_1881"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1783"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075826_0_2_12"/>
    <dbReference type="OMA" id="FNWLMPY"/>
    <dbReference type="OrthoDB" id="1827334at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="183" mass="20746" checksum="3B5BE96B09758129" modified="2004-07-05" version="1">MRITGGSLKNRQVECPKGIIRPAMDRMRESVFSILGDLSGLSFLDLFTGSGVCGLEAYSRGAYPVYLVEKDADKFPVLLKNVSMADKKLECKRMPAETFIKRAKESFDIIYLDPPFPYKFHIELLEKIEESKILKEGGLVMMHRPSEKAMPQTIGSLTKSDERVYGRSIVDFYRKKIPGENDV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LW3</accession>
    <name>RL27_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmA</name>
        <name type="ordered locus">TDE_1749</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972353.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669471.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73LW3"/>
    <dbReference type="SMR" id="Q73LW3"/>
    <dbReference type="STRING" id="243275.TDE_1749"/>
    <dbReference type="EnsemblBacteria" id="AAS12264">
        <property type="protein sequence ID" value="AAS12264"/>
        <property type="gene ID" value="TDE_1749"/>
    </dbReference>
    <dbReference type="GeneID" id="2740594"/>
    <dbReference type="KEGG" id="tde:TDE_1749"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1672"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095424_4_1_12"/>
    <dbReference type="OMA" id="GKDHTLH"/>
    <dbReference type="OrthoDB" id="1904463at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000181196" description="50S ribosomal protein L27">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <sequence length="83" mass="8766" checksum="C70D47BE6011328C" modified="2004-07-05" version="1">MARKKGGSGAKNGRDSNPKYLGVKVYGGTEVSAGSILVRQRGTSIHPGNNVGCGKDYTLFAKADGVVTYHERKGRKLASIEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LX2</accession>
    <name>Q73LX2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972344.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12255">
        <property type="protein sequence ID" value="AAS12255"/>
        <property type="gene ID" value="TDE_1740"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1740"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1663"/>
    <dbReference type="HOGENOM" id="CLU_3105023_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="51" mass="5863" checksum="694BCE2D206D042D" modified="2004-07-05" version="1">MQIREGRLYHKRLDKKKSRLKNRPAHQAIGGRWVGGEPSADIYLSAKDTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LX6</accession>
    <name>Q73LX6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin, 2(4Fe-4S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972340.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670897.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1736"/>
    <dbReference type="EnsemblBacteria" id="AAS12251">
        <property type="protein sequence ID" value="AAS12251"/>
        <property type="gene ID" value="TDE_1736"/>
    </dbReference>
    <dbReference type="GeneID" id="2739194"/>
    <dbReference type="KEGG" id="tde:TDE_1736"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1659"/>
    <dbReference type="eggNOG" id="COG2221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_11_4_12"/>
    <dbReference type="OMA" id="DECTYCA"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="56" mass="5669" checksum="8C731909FF706741" modified="2004-07-05" version="1">MAYKISNECTNCAACESECPVNAISEAGGKHVIDADTCISCGACAGVCPVEAISEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LZ8</accession>
    <name>Q73LZ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylmuramoyl-L-alanine amidase, family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972318.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679426.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1714"/>
    <dbReference type="EnsemblBacteria" id="AAS12229">
        <property type="protein sequence ID" value="AAS12229"/>
        <property type="gene ID" value="TDE_1714"/>
    </dbReference>
    <dbReference type="GeneID" id="2740886"/>
    <dbReference type="KEGG" id="tde:TDE_1714"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1639"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014322_0_0_12"/>
    <dbReference type="OMA" id="WFVIKNS"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012854">
        <property type="entry name" value="Cu_amine_oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036582">
        <property type="entry name" value="Mao_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07833">
        <property type="entry name" value="Cu_amine_oxidN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55383">
        <property type="entry name" value="SSF55383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284595" evidence="1">
        <location>
            <begin position="25"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="183"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="337" mass="38185" checksum="5D8C071132ADC336" modified="2004-07-05" version="1">MKNRANKAFFSIFLLVFLCLKAFSAGVSVTDAAGRLDLDISWDPLSQELIFIKNNSQVSCKIGESLIIFDNEKADFTPPPYQKDGLTFISGEMYKKLETFFAVPQKEENYRVGVILIDPGHGGKDPGCVGSYVENKKTFVLYEKDIALKVSLDLYKMLKKAYPDKKILLTRNKDVYPTLEDRVNMANSVKLKKNESILYVSIHVNASLSSKAAGFEVWYLPPEYRREVVDKKTVPKEIHSILNSMMEEEFTMESILMAQNILDGLDAQIGKKSPNRGIRENQWFVVRNVKMPSVLIELGFISNKTEIKLLNSPDYLKKCSLGIYNGLSAFISNFENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M88</accession>
    <name>Q73M88_TREDE</name>
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        <recommendedName>
            <fullName evidence="1">ATPase_AAA_core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972227.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679308.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1621"/>
    <dbReference type="EnsemblBacteria" id="AAS12138">
        <property type="protein sequence ID" value="AAS12138"/>
        <property type="gene ID" value="TDE_1621"/>
    </dbReference>
    <dbReference type="GeneID" id="2740862"/>
    <dbReference type="KEGG" id="tde:TDE_1621"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1549"/>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021240_1_0_12"/>
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    <dbReference type="OrthoDB" id="318943at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TOPRIM_OLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034139">
        <property type="entry name" value="TOPRIM_OLD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13304">
        <property type="entry name" value="AAA_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="34"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="596" mass="68714" checksum="9E2027B5C6A68ACC" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M94</accession>
    <name>Q73M94_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS12132">
        <property type="protein sequence ID" value="AAS12132"/>
        <property type="gene ID" value="TDE_1615"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1615"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1544"/>
    <dbReference type="eggNOG" id="ENOG502ZEAI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2083833_0_0_12"/>
    <dbReference type="OMA" id="MNNSCNI"/>
    <dbReference type="OrthoDB" id="1775064at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="133" mass="15292" checksum="2E54AE94D80F4A88" modified="2004-07-05" version="1">MYTILLSIGNALKRNYMNWKLIYFLLIVLFLGLFAGFNMNNSCNISLIFYTFENVPVYVSNIFSFLIGLILTIPFLFGSKKKKNKPLNEKKETFTASDGVGIDTVDLKKPKKSWFKRKKESTTPITDTNSEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M96</accession>
    <name>Q73M96_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972219.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679299.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1613"/>
    <dbReference type="EnsemblBacteria" id="AAS12130">
        <property type="protein sequence ID" value="AAS12130"/>
        <property type="gene ID" value="TDE_1613"/>
    </dbReference>
    <dbReference type="GeneID" id="2740854"/>
    <dbReference type="KEGG" id="tde:TDE_1613"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1542"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076101_1_0_12"/>
    <dbReference type="OMA" id="PGENERI"/>
    <dbReference type="OrthoDB" id="1906165at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="204" mass="23916" checksum="1935E4DA8668C054" modified="2004-07-05" version="1">MRKNIFIVFLGALFFICFTKVFAKGAVEEDLAGEYFSIAQGYTELKNYSKAADYYLKAEKSEKYKNAAQYNLAQVYALQNEWDNCLKYIEPLYKQAPENIKISTAYAYALASSGKEEKALLIYEKIYLENKETPEYFFNYVRILIIVKKYEKAKELLNESKEKFTQEDDKKTISELEKEIEKLLNPPELKKDSTQDDKKSEERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MC0</accession>
    <name>Q73MC0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine-binding chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheW-2</name>
        <name evidence="2" type="ordered locus">TDE_1589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972195.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669135.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1589"/>
    <dbReference type="EnsemblBacteria" id="AAS12106">
        <property type="protein sequence ID" value="AAS12106"/>
        <property type="gene ID" value="TDE_1589"/>
    </dbReference>
    <dbReference type="GeneID" id="2739786"/>
    <dbReference type="KEGG" id="tde:TDE_1589"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1519"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_1_12"/>
    <dbReference type="OMA" id="CVNIMSV"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="168" mass="18982" checksum="83FBAC2CA3A4099F" modified="2004-07-05" version="1">MANAGGLNKKAKVENDDLLKLVTFQLGEELYGVEIMDVDQIVRVQDVRPIPNAPYYVEGIFNLRSEIIPVISLHKRFHIKKASLDEGDEFLGGFIIIKVENNKIGIIIDRVARVVDVKKEEIQPPPQMIAGIGAEYINGVVRRDPGYLIILDIHRLFNPKELQKITNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MD1</accession>
    <name>Q73MD1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972184.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679247.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1578"/>
    <dbReference type="EnsemblBacteria" id="AAS12095">
        <property type="protein sequence ID" value="AAS12095"/>
        <property type="gene ID" value="TDE_1578"/>
    </dbReference>
    <dbReference type="GeneID" id="2739775"/>
    <dbReference type="KEGG" id="tde:TDE_1578"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1507"/>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_2_1_12"/>
    <dbReference type="OMA" id="KELMECM"/>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="4">
        <location>
            <begin position="28"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="219" mass="24695" checksum="7A433EAE6AEB9C95" modified="2004-07-05" version="1">MNSLEYFNKGIFASPEALEKLKSAEKARLILISDTHGNVDTIIDILGREGKKSDAVLFSGDGLADFLNYITISQYEKELMECMPPVAALVMGNCDSKKYVLNLDARKTGADFGFKKNPERYLEFFEFLFLETCRKKILLTHGHEFYVDFELNTLLNFARQQDCSVAVFGHTHVPLIKEVNGIFLINPGSVSRPRMGSNKSYGILTMSKDAKPSMEFKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MD7</accession>
    <name>Q73MD7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972177.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1571"/>
    <dbReference type="EnsemblBacteria" id="AAS12088">
        <property type="protein sequence ID" value="AAS12088"/>
        <property type="gene ID" value="TDE_1571"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1571"/>
    <dbReference type="HOGENOM" id="CLU_3391910_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="32" mass="4156" checksum="66B0DCDB8B87BE56" modified="2004-07-05" version="1">MKNMLKRRMKQKRLFDEEDRLRVLSKYTKSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MD8</accession>
    <name>Q73MD8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972176.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679240.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1570"/>
    <dbReference type="EnsemblBacteria" id="AAS12087">
        <property type="protein sequence ID" value="AAS12087"/>
        <property type="gene ID" value="TDE_1570"/>
    </dbReference>
    <dbReference type="GeneID" id="2739320"/>
    <dbReference type="KEGG" id="tde:TDE_1570"/>
    <dbReference type="eggNOG" id="ENOG5030WYS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1805325_0_0_12"/>
    <dbReference type="OrthoDB" id="2093897at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="154" mass="18092" checksum="859D36783CCBA8F7" modified="2004-07-05" version="1">MPRYIDNFFIILSFLPGLYWIILYILLLLYVIASWLGRLNRKMKTIIFSSLAVDTWFHIFRYTILPSIILIIFTIILGKRMYYGNMDYRYGSIKILIIFIVGVIWFLGAWIISSIQKKRAENGDLGFAYKMTAILSCILFPLIALIIVFFLVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MN9</accession>
    <name>Q73MN9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972075.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679136.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1469"/>
    <dbReference type="EnsemblBacteria" id="AAS11986">
        <property type="protein sequence ID" value="AAS11986"/>
        <property type="gene ID" value="TDE_1469"/>
    </dbReference>
    <dbReference type="GeneID" id="2741584"/>
    <dbReference type="KEGG" id="tde:TDE_1469"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1410"/>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087829_3_0_12"/>
    <dbReference type="OMA" id="FTDDAIC"/>
    <dbReference type="OrthoDB" id="1827295at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="143" mass="15922" checksum="B8D22BB47989F3F4" modified="2004-07-05" version="1">MEFTVKTEEDTINLGKKIGKKLKKGDVVALDGSLAAGKTYLTKGIAQGLDIEEDITSPTFTLISEYSGRLHLYHMDVYRLEGVEDFLDLGTEEMLYGDGVCVIEWSKKVKQVLPPNTIYIGIMVNDDNSRKIIIDNKDFCGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MQ7</accession>
    <name>Q73MQ7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972057.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1451"/>
    <dbReference type="EnsemblBacteria" id="AAS11968">
        <property type="protein sequence ID" value="AAS11968"/>
        <property type="gene ID" value="TDE_1451"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1451"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1392"/>
    <dbReference type="eggNOG" id="ENOG5031DN4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653650_0_0_12"/>
    <dbReference type="OMA" id="DCDSRAM"/>
    <dbReference type="OrthoDB" id="1763634at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="372" mass="42423" checksum="E7A03CF38BAB82B8" modified="2004-07-05" version="1">MYSPSWGYALDLPEDFVLANREGNERYLFQHAILPVDLQIALYEAPQFKSVKEAAEHVFKQLKMTHKDVPFVWRNKEALLSSVSFLYSPSEKYKPKELSGWVLSLELPNKTGWLVLLTYTDKDKAKECENLMISSIDTVYTDTMSYFEPGPVTTALYPKTKEKTIEYTFNNKNISFTIDESDAEANKSVIDREFSVLTIYLNHDNLIAAWQRFYKIIFRDAWNRIAPASFAVYTSLFDENNQNGFAEKAAKELLLLVQNFNYERDRKGSDFINLPQALTEKRGDCDSRALLMVLMLKQMNIDAVLLVSPNKSHAIAAVDCPGSGTCFTHNGKTYLGCETTAHVPIGEIADEIAAPENWFPVDFYVIENFESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MR6</accession>
    <name>Q73MR6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rfbB</name>
        <name evidence="7" type="ordered locus">TDE_1441</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972047.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679073.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1441"/>
    <dbReference type="EnsemblBacteria" id="AAS11958">
        <property type="protein sequence ID" value="AAS11958"/>
        <property type="gene ID" value="TDE_1441"/>
    </dbReference>
    <dbReference type="GeneID" id="2741404"/>
    <dbReference type="KEGG" id="tde:TDE_1441"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1382"/>
    <dbReference type="eggNOG" id="COG1088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_12"/>
    <dbReference type="OMA" id="KLIPLMC"/>
    <dbReference type="OrthoDB" id="707977at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="8"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="362" mass="41518" checksum="3349856F9F4D2442" modified="2004-07-05" version="1">MRSLQNILVTGGAGFIGSNFIRTLLKKEDAFTGRIINLDALTYAGNAASLADMESEFGGSRYFFIHGNICDKEIINSIFTEYNIDTVVHFAAESHVDRSILGPEVFLKTNVLGTFNLLETAKQFWKKPDGTMRDDVLFHHISTDEVYGSLGTEGYFKETTAYDPRSPYSASKASSDHLVKAYFHTYGLPATISNCSNNYGPFQFPEKLIPLMILNMLEGKNLPVYGDGKQIRDWIHVEDHNEAVRLILKNGRAGKTYNIGGENEWENIKLLNKLIQIVCKKTGLEEENVRKTITHVTDRLGHDRRYAIDCTKIKNELNWKRNFDFETGLENTVDWYLNNKKWIENVRSGEYRNWIEKNYKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MR9</accession>
    <name>Q73MR9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972044.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679065.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1438"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="DNASU" id="2741401"/>
    <dbReference type="EnsemblBacteria" id="AAS11955">
        <property type="protein sequence ID" value="AAS11955"/>
        <property type="gene ID" value="TDE_1438"/>
    </dbReference>
    <dbReference type="GeneID" id="2741401"/>
    <dbReference type="KEGG" id="tde:TDE_1438"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1379"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_12"/>
    <dbReference type="OMA" id="FARQKDH"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="183"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="356" mass="40018" checksum="2B3EC935322DA3C8" modified="2004-07-05" version="1">MKILHIITNTELGGAQTVCISLANMASDEGNIVAVASMNGGYLWDNLSSSVIQFKIKNMIKPIRLLPDLKCYFELKKVINEFAPDIIHLHSSKAGTLGRLAGFKYRKKIIYTVHGFDSIRLHHRIFLPLERFLQRFCGAIVAVSKYDEKKLYKEKITKNIKTIYNGISLNSVDSPKPFDSSSYKKVIMTIARISRQKRFESFLSIASDPVMKDYLFVWVGGSAEKSMDEIKKDYSIPSNVLLLGDYPNASSLLPYCDLFVLFSNYEGLPMTIIEAMAYKKAIVASNVGGISELVDVTNGALIETDDGAVEAIGAILQDDEKKAKMGKASFEKFSKFFTLDIMWKNYRSLYKEIAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MT5</accession>
    <name>Q73MT5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972028.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679034.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1422"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11939">
        <property type="protein sequence ID" value="AAS11939"/>
        <property type="gene ID" value="TDE_1422"/>
    </dbReference>
    <dbReference type="GeneID" id="2739699"/>
    <dbReference type="KEGG" id="tde:TDE_1422"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1363"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_0_4_12"/>
    <dbReference type="OMA" id="NINFLPW"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="341" mass="40079" checksum="2EAD97808C8EB691" modified="2004-07-05" version="1">MNNTITVIIPTYNKADFISQTIESVLQQTYKNFEIVIIDDCSSDNTEGVVQKYLSGKIRYFKHKTNWGPGVTFNDGIEKAQSEYVTLIASDDILLPAHLELVINEFKKDKKIETVFSKLQVIDENNNYLNKIQEPPYIDKYKLLNTLFYIENRIPSPGIAFKKSLFNKTKMFNPNLILMHDYDLNIRCMMYGEIAVLPEPTVLYRRFSDNCNLSGDNNWYAYCHTAENNIILDNYLNLTYTDMIKTFPDLESCLEKDIKFNFISKTCKNEQKRLSEWAFEKLIEYLNTHPDFFCNNDLNFQYKDYIDLYKAHAEKNIIKLTHKQKLFKMMKDTAKMPFGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MT6</accession>
    <name>Q73MT6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972027.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1421"/>
    <dbReference type="EnsemblBacteria" id="AAS11938">
        <property type="protein sequence ID" value="AAS11938"/>
        <property type="gene ID" value="TDE_1421"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1421"/>
    <dbReference type="HOGENOM" id="CLU_3391909_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="32" mass="4087" checksum="6D5B20174A1B0886" modified="2004-07-05" version="1">MFFPYYLADFYKQLKFLNEYQTKNKDKVVEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MW9</accession>
    <name>Q73MW9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA pseudouridylate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971993.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678971.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1387"/>
    <dbReference type="EnsemblBacteria" id="AAS11904">
        <property type="protein sequence ID" value="AAS11904"/>
        <property type="gene ID" value="TDE_1387"/>
    </dbReference>
    <dbReference type="GeneID" id="2741148"/>
    <dbReference type="KEGG" id="tde:TDE_1387"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1329"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_1_0_12"/>
    <dbReference type="OMA" id="HAFLVKF"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="96"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="305" mass="34256" checksum="8F524943F63ABEE2" modified="2004-07-05" version="1">MSKENKIFYIGEDDSGRRLDRVIRKFLGKMPLSGVYSAIRRGKIRVNGKKENGAYLTQKGDEISMDLSLFGLTAPASEDQTNYSISKPDVLLKTDDLLFINKRSGELVHGEKSLCEAVLKYFPSKEKSLSFKVGALHRLDKDTSGILAFSQSLKGAQGFSRALQEGKIGKFYIGITEGRPSLSEFKSIIDGKECLCLIRILDFSKEENLSLVLFNLITGRKHQIRIQCSQFGTPLLNDKKYGSKQKKAFSEDLSKKTTYFLHAYKLIFSEPFLDDLPKEITAPLPENFKRAVKSLFGIDLASLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MZ4</accession>
    <name>Q73MZ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971968.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1362"/>
    <dbReference type="EnsemblBacteria" id="AAS11879">
        <property type="protein sequence ID" value="AAS11879"/>
        <property type="gene ID" value="TDE_1362"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1362"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1308"/>
    <dbReference type="eggNOG" id="COG3210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010206_0_0_12"/>
    <dbReference type="OrthoDB" id="1809412at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1023" mass="108608" checksum="1EADA4841839F4A1" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N10</accession>
    <name>Q73N10_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor RpoD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sigma-70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoD</name>
        <name evidence="11" type="ordered locus">TDE_1346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971952.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678907.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1346"/>
    <dbReference type="EnsemblBacteria" id="AAS11863">
        <property type="protein sequence ID" value="AAS11863"/>
        <property type="gene ID" value="TDE_1346"/>
    </dbReference>
    <dbReference type="GeneID" id="2739447"/>
    <dbReference type="KEGG" id="tde:TDE_1346"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1294"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_7_2_12"/>
    <dbReference type="OMA" id="RIEMYYE"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="9">
        <location>
            <begin position="409"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="10">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="385"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="464"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="553"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="273"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="409"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="619" mass="71855" checksum="128D0E0C03386BF4" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N13</accession>
    <name>Q73N13_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trypsin domain/PDZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971949.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678901.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1343"/>
    <dbReference type="MEROPS" id="S01.454"/>
    <dbReference type="EnsemblBacteria" id="AAS11860">
        <property type="protein sequence ID" value="AAS11860"/>
        <property type="gene ID" value="TDE_1343"/>
    </dbReference>
    <dbReference type="GeneID" id="2741077"/>
    <dbReference type="KEGG" id="tde:TDE_1343"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1291"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026857_0_0_12"/>
    <dbReference type="OMA" id="MHRKIFI"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="536" mass="59755" checksum="DA4699706D463BE7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N22</accession>
    <name>Q73N22_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971940.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1334"/>
    <dbReference type="EnsemblBacteria" id="AAS11851">
        <property type="protein sequence ID" value="AAS11851"/>
        <property type="gene ID" value="TDE_1334"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1334"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1282"/>
    <dbReference type="eggNOG" id="COG3334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111537_0_0_12"/>
    <dbReference type="OMA" id="LLWFDYL"/>
    <dbReference type="OrthoDB" id="1752611at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="216" mass="24718" checksum="CF4D40EFDCAD87D4" modified="2004-07-05" version="1">MIVWEVKILRRSGTIGRIIVLLILIVLLVFGGLLWFDYLGLISSRSLFSPIYSFFGLKTPEGIAPLDSDEMANLENDRYEKRLMALELRSQELDKREEDVQTQENENKQVAEELDDRRLAIEEKEKNYNLLVVERDAREANIIQIAKYINGMPPEKAVSNLIAMDDQDIIDVLRAVEKIAAEEGKNSSVAYWFSLMPASRAAEIQRKMANKPVTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N50</accession>
    <name>Q73N50_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971912.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678829.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1306"/>
    <dbReference type="EnsemblBacteria" id="AAS11823">
        <property type="protein sequence ID" value="AAS11823"/>
        <property type="gene ID" value="TDE_1306"/>
    </dbReference>
    <dbReference type="GeneID" id="2739564"/>
    <dbReference type="KEGG" id="tde:TDE_1306"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1255"/>
    <dbReference type="eggNOG" id="ENOG5031CPP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131006_0_0_12"/>
    <dbReference type="OrthoDB" id="1712637at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="140" mass="16406" checksum="C440BCCD932CC521" modified="2004-07-05" version="1">MMDFIHDRSSNIPFSLHDSKIKKIIFNDDILTLKIDKLFQYTENGEKKYSGDVVFYVSDLDECSVWIFDKIVYEGDFSGKAIGLKEYIENFSGMEFEILTEGYFGYNTTYTGWLWEEGKEPVSAAMYIWNTGDMVYRIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N83</accession>
    <name>Q73N83_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971879.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678774.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1272"/>
    <dbReference type="EnsemblBacteria" id="AAS11790">
        <property type="protein sequence ID" value="AAS11790"/>
        <property type="gene ID" value="TDE_1272"/>
    </dbReference>
    <dbReference type="GeneID" id="2740565"/>
    <dbReference type="KEGG" id="tde:TDE_1272"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1223"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_12"/>
    <dbReference type="OMA" id="PHGRVKA"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="328" mass="36508" checksum="0D4ADC004A1A9240" modified="2004-07-05" version="1">MPKLLSVKELTVRFAGKEGYTTIVDRVSFDVQNGEILCVVGESGCGKSTIAMSILQLLSINGEISGGHIIMDGQELTNLTEDEMCEIRGNNISMIFQDPMSSLNPTKTVASQLIEPYIIHKGMKRKAARAEALNILKDVGIPNPEKRLDEYPHQLSGGMRQRVMIAMALACQPKLLIADEPTTALDVTIQAQILDLMRTLRKERGTAIVFITHDLGVVAEMADKVLVLYAGHAVEYNTVEKVFNSPKHPYTMGLLKSVPPVDKHIDFLPSIEGIVPTPGNMPKGCRFYPRCKNRMDICKNSEPKEYNLEDGWVKCFLYSNLKEDKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NA7</accession>
    <name>Q73NA7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971855.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678741.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1248"/>
    <dbReference type="EnsemblBacteria" id="AAS11766">
        <property type="protein sequence ID" value="AAS11766"/>
        <property type="gene ID" value="TDE_1248"/>
    </dbReference>
    <dbReference type="GeneID" id="2741424"/>
    <dbReference type="KEGG" id="tde:TDE_1248"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1200"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054927_2_0_12"/>
    <dbReference type="OMA" id="WNVTARY"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="37"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="314" mass="35110" checksum="0EFF9979F95B61F3" modified="2004-07-05" version="1">MKTGFIAERAKQLKISSLSISEGLRSGGFSSAFRGQGIEFDSVREYETGDDVRSIDWNLTARSGKTYVKMYREERDLSIFICVDFSLSMEPGLDKISPKEKAIETAALLAFAGRNIFSPVGALFFDGEKGPLFIPRTGEEHILTILKSMEDFAFCKNRKPVRGTQIASAMTAASKILRSRSLVIIISDFKVEGYEKELGLLAAKHDVVCLKISGSMDSFLPEAGSIRFKDPETDFRMLLPTGSKTFQMEYKKNFTEEISRWENTCKHSLANPVLLDVNDDTVKVLGDFFLSKQSNQRVLKNNLAKFGADGWKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NF7</accession>
    <name>Q73NF7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971803.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1196"/>
    <dbReference type="EnsemblBacteria" id="AAS11714">
        <property type="protein sequence ID" value="AAS11714"/>
        <property type="gene ID" value="TDE_1196"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1196"/>
    <dbReference type="HOGENOM" id="CLU_3158998_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="48" mass="5930" checksum="4E87F6E314DAF88C" modified="2004-07-05" version="1">MSSGLYRKSVFFLFFLLFFLNYLKKNIVSSIYYMRFVNKPLEKTFFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NH2</accession>
    <name>Q73NH2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron compound ABC transporter, periplasmic iron compound-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971788.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671710.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1180"/>
    <dbReference type="EnsemblBacteria" id="AAS11699">
        <property type="protein sequence ID" value="AAS11699"/>
        <property type="gene ID" value="TDE_1180"/>
    </dbReference>
    <dbReference type="GeneID" id="2740077"/>
    <dbReference type="KEGG" id="tde:TDE_1180"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1138"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_2_3_12"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284974" evidence="1">
        <location>
            <begin position="21"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="48"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="304" mass="34041" checksum="F729D135317E87D3" modified="2004-07-05" version="1">MKNKLFIILGFLCMSTLLFAGGSKEGSTKQEKGREMYGYMVPASVPQRTAVGQVVLLQMLDMLDVDIVARPSTKREISARYKDKTEIGMPMRVDLEKLKEVNPDFYLATGDRGAPIAEQLKALNIPAEFLQTTTYTDILNSMKYLGEVYNKQKEAAAYVKEVEDVVAKVKAANKNKKPLKVLIIAGFPNSMSIHTEGSFVGSLIKVLGAENIWKDNTVKNTTVPMNLELVKASNPDIILLTSHGDAKDTAKMYEKEFQSDFWQKIDAVKNKRYYSLDTRIFFIAGSPYIPEALETLGNYFYGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NJ9</accession>
    <name>Q73NJ9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971761.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956900.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1153"/>
    <dbReference type="EnsemblBacteria" id="AAS11642">
        <property type="protein sequence ID" value="AAS11642"/>
        <property type="gene ID" value="TDE_1153"/>
    </dbReference>
    <dbReference type="GeneID" id="2741485"/>
    <dbReference type="KEGG" id="tde:TDE_1153"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1112"/>
    <dbReference type="eggNOG" id="ENOG5032S64">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086933_0_0_12"/>
    <dbReference type="OrthoDB" id="1835925at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13392">
        <property type="entry name" value="HNH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="118"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="198" mass="22685" checksum="F918DA1E2F9BE711" modified="2004-07-05" version="1">MSKLFPDHIIFYIKENVKGKSTAELTELVNQVFATNYTEAQIRTCKHNRHIKSGLTGHFPKGHTPYNKGRKGYYSPGCEKGWFKKGNIPKNHRPVGSERIDTNGYVYIKIKEPNVWCLKHVRIYEKKHGSVPKGMIVTFKDGNKQNCSIENLLLMSRAEAAVMTHFKLRGNTPELMETGVLVSKIILQKSKLKKKQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NN3</accession>
    <name>Q73NN3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971727.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671735.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1119"/>
    <dbReference type="EnsemblBacteria" id="AAS11608">
        <property type="protein sequence ID" value="AAS11608"/>
        <property type="gene ID" value="TDE_1119"/>
    </dbReference>
    <dbReference type="GeneID" id="2739535"/>
    <dbReference type="KEGG" id="tde:TDE_1119"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1079"/>
    <dbReference type="eggNOG" id="ENOG5031CXJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1331441_0_0_12"/>
    <dbReference type="OMA" id="CNIRGED"/>
    <dbReference type="OrthoDB" id="1866346at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="206" mass="23878" checksum="60B1C95259367ADF" modified="2004-07-05" version="1">MKLKKYRIIFSFVFLFSLYNESGAEENSFSTILEEAKKYFSDIDWTVSETISASPMAEPFTLDEIKTENLSSYGDTDLRESLFPSLDGLGVLDYTGIEKSVLNFLNKLSLQFKENKVDISLCSKAKPFLPYLINYRLDSFKPIVSVFYGRPENKADQKVKALFKCNIRGEDKIFYIIIEVYIIFIEEKWYLDSFDIIGDKNEQSSQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-29" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NV3</accession>
    <name>EFG2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor G 2</fullName>
            <shortName evidence="1">EF-G 2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fusA2</name>
        <name type="synonym">fusA-2</name>
        <name type="ordered locus">TDE_1049</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971657.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682356.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NV3"/>
    <dbReference type="SMR" id="Q73NV3"/>
    <dbReference type="STRING" id="243275.TDE_1049"/>
    <dbReference type="EnsemblBacteria" id="AAS11538">
        <property type="protein sequence ID" value="AAS11538"/>
        <property type="gene ID" value="TDE_1049"/>
    </dbReference>
    <dbReference type="GeneID" id="2741323"/>
    <dbReference type="KEGG" id="tde:TDE_1049"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1009"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_0_12"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045044">
        <property type="entry name" value="EFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="PTHR43636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091253" description="Elongation factor G 2">
        <location>
            <begin position="1"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="6"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="82"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <sequence length="695" mass="77277" checksum="D945256A7DFABE63" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NW5</accession>
    <name>Q73NW5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971645.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956867.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1037"/>
    <dbReference type="EnsemblBacteria" id="AAS11526">
        <property type="protein sequence ID" value="AAS11526"/>
        <property type="gene ID" value="TDE_1037"/>
    </dbReference>
    <dbReference type="GeneID" id="2741515"/>
    <dbReference type="KEGG" id="tde:TDE_1037"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.997"/>
    <dbReference type="HOGENOM" id="CLU_918092_0_0_12"/>
    <dbReference type="OrthoDB" id="2118473at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="71"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="303" mass="34600" checksum="6034462A1068A7F2" modified="2004-07-05" version="1">MKKNIILAFAWFCLAFAVIAFFTNELRRFNRLGYKDFMRFGIINGKFNPHTSVLKEMQFDINEIRFIKASLISEDIKFIPSNDDKIIVKIIGIEENKKLPEIKKEKDALIIKAFETEKKRFFFGWDYSHRIEISIPSAELYIAENAENGSAENTISAFIESTSSDIRIYDITLKNLHFKSVSGDVIFRNSKIENQFEFNTKSGDIRGEAFIYGFAGTSVSGDFRLRFLSAPKNDSTFNSTSGDFSIYLPKDITGFSCDFNSSSGDYKNSFTGSSAEKKIYDVYKTDSPRLFIKTVSGDCRIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NW6</accession>
    <name>Q73NW6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971644.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682346.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1036"/>
    <dbReference type="EnsemblBacteria" id="AAS11525">
        <property type="protein sequence ID" value="AAS11525"/>
        <property type="gene ID" value="TDE_1036"/>
    </dbReference>
    <dbReference type="GeneID" id="2741514"/>
    <dbReference type="KEGG" id="tde:TDE_1036"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.996"/>
    <dbReference type="eggNOG" id="ENOG5030IH7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105892_0_0_12"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="222" mass="25358" checksum="EC9E4F687716A909" modified="2004-07-05" version="1">MNEKIKNYVGLLFEGVPQSRKAIELRNEILANLNDRFEALLAEGKSEHEAYGFAIAGLGDVDELIKTVLPNKEITEKIDKERKRKGFLTSIAVALYILSPAVLIFLSTFHYDNIGVVLLLSMAAVATSILIYANMSTPSEVQSYFKKEEKIFSHNNYGSNKNYFFTSLEKFYWTLVPLVYLAVSFYTHAWHISWLIFIAAIAVWQGVKLLIIWSNYKNEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NY4</accession>
    <name>Q73NY4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">xseA</name>
        <name evidence="9" type="ordered locus">TDE_1017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971625.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682333.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1017"/>
    <dbReference type="EnsemblBacteria" id="AAS11506">
        <property type="protein sequence ID" value="AAS11506"/>
        <property type="gene ID" value="TDE_1017"/>
    </dbReference>
    <dbReference type="GeneID" id="2740997"/>
    <dbReference type="KEGG" id="tde:TDE_1017"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.978"/>
    <dbReference type="eggNOG" id="COG1570">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023625_3_1_12"/>
    <dbReference type="OMA" id="WPAVRFE"/>
    <dbReference type="OrthoDB" id="1371775at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="122"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="398" mass="44124" checksum="B96476DE23533568" modified="2004-07-05" version="1">MAQTYSVYEITLQIKELLESGFGYVSIEGEISNFRPSAAGHLYFILKDEKASIQAVMFKGKTRSLSFVPKDGMTVKAEGAISVYEQRGSYQIIIEEMSLAGEGNILKMLEERKKKLAAEGIFDSERKKPLPYFPKRIAVITSPTGAAVRDIINVVKRRNEKIGIVVLPAIVQGEEAAPVLIRQLKIADEKNLGDLIIIGRGGGSLEDLLPFSDEELVRAIAACKTPVISAVGHEIDWALSDFAADMRAPTPSAAAELAAPILNDIMYSIAVNREDLTQNIENRIERIRLMLNNFKPDSLELRFRNIQQPLLARFDNAKEEILSGMQERCKDLRQRLLVLNKILEGANPQGILDRGYSIVRNAQTGKTIRSFSQVKEGEALLIQPSKGTIEAEVKRVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NZ3</accession>
    <name>Q73NZ3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar basal-body rod protein FlgG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Distal rod protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">flgG-2</name>
        <name evidence="8" type="ordered locus">TDE_1007</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971616.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670463.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1007"/>
    <dbReference type="EnsemblBacteria" id="AAS11497">
        <property type="protein sequence ID" value="AAS11497"/>
        <property type="gene ID" value="TDE_1007"/>
    </dbReference>
    <dbReference type="GeneID" id="2740987"/>
    <dbReference type="KEGG" id="tde:TDE_1007"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.967"/>
    <dbReference type="eggNOG" id="COG4786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013687_0_1_12"/>
    <dbReference type="OMA" id="TRDGTFH"/>
    <dbReference type="OrthoDB" id="1488472at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009426">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012834">
        <property type="entry name" value="FlgG_G_neg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02488">
        <property type="entry name" value="flgG_G_neg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="7">
        <location>
            <begin position="184"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="264" mass="28792" checksum="EBD3D9A7F6C1D4FF" modified="2004-07-05" version="1">MVRSLWTAATGMNTQQANIDTVANNLANVNTSGFKKQRAEFEDLIYQTVKTAGTPATEDTITPVGVQMGHGARLAATQRIFEQGSLQNTGVTSDIAIQGEGFFRVLQYDGTYAYTRDGSFKIDADRQLVTSNGLRVLPEIIFPEGYRENTIAVSRDGRVTVKVGDIDDPIEVGQIELYRFQNNAGLSAEGSNLFRQTPASGTAIPGRPGFTGFGRTEHKFLEMSNVSTVSEMVNMIVAQRAYEFNSKAIQTSDNMLGTAVSLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NZ4</accession>
    <name>Q73NZ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flagellar basal-body rod protein FlgG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">flgG-1</name>
        <name evidence="5" type="ordered locus">TDE_1006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971615.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671871.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1006"/>
    <dbReference type="EnsemblBacteria" id="AAS11496">
        <property type="protein sequence ID" value="AAS11496"/>
        <property type="gene ID" value="TDE_1006"/>
    </dbReference>
    <dbReference type="GeneID" id="2740986"/>
    <dbReference type="KEGG" id="tde:TDE_1006"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.966"/>
    <dbReference type="eggNOG" id="COG4786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013687_0_0_12"/>
    <dbReference type="OMA" id="NLYFAIQ"/>
    <dbReference type="OrthoDB" id="947161at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012836">
        <property type="entry name" value="FlgF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02490">
        <property type="entry name" value="flgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="3">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="4">
        <location>
            <begin position="192"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="270" mass="30185" checksum="F5E92BDA21F05924" modified="2004-07-05" version="1">MVRGWYTAASGMLAQQRQLDVISNNLANLDTTSFKRDVSVQKSFPELLLRRLNDDGVIKNPFGSSDIAPIIGKLGLGVETNEIFTEFEQGSLKQTSSPADLALEGQGFFAVETPYGEKYTRNGNFMIGVEGYLMTKEGYPVMGENGRIFLQDMEYKINQDGQIYVRPITEPESDSVYLDRLKIVEFENDRYLSKNGSSFYLDTPLSGKAIAAEGPSRPVVVQGFIEASNVNVVNEMVRMIEVNRAYEANQKSIQAEDTMMAKLWNEAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P12</accession>
    <name>Q73P12_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oligopeptide/dipeptide ABC transporter, peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971597.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682301.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0988"/>
    <dbReference type="EnsemblBacteria" id="AAS11478">
        <property type="protein sequence ID" value="AAS11478"/>
        <property type="gene ID" value="TDE_0988"/>
    </dbReference>
    <dbReference type="GeneID" id="2739065"/>
    <dbReference type="KEGG" id="tde:TDE_0988"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.950"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026689_0_0_12"/>
    <dbReference type="OMA" id="VLPKHWW"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="140"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="647" mass="75308" checksum="A48DA52660ADA31F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P31</accession>
    <name>EFP_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor P</fullName>
            <shortName evidence="1">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">efp</name>
        <name type="ordered locus">TDE_0968</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971578.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671939.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73P31"/>
    <dbReference type="SMR" id="Q73P31"/>
    <dbReference type="STRING" id="243275.TDE_0968"/>
    <dbReference type="EnsemblBacteria" id="AAS11459">
        <property type="protein sequence ID" value="AAS11459"/>
        <property type="gene ID" value="TDE_0968"/>
    </dbReference>
    <dbReference type="GeneID" id="2740540"/>
    <dbReference type="KEGG" id="tde:TDE_0968"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.932"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074944_0_2_12"/>
    <dbReference type="OMA" id="WSVVEFQ"/>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000094359" description="Elongation factor P">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <sequence length="187" mass="21101" checksum="B3611FD919D4505D" modified="2004-07-05" version="1">MIRGGDIAKGTVLLNKGTPYLVVEREFVNPGKGAAFARVKMKNLRDGSVLMQTIKTADTVEDAVVDTHKCQYQYKDGDQFMFMDTESFESISVPAETIGDKEHYLREGDEYDILIWENEPIDVRIPTKMIFIVEQSENYIKGDTVSGATKPIVTETGLVVRVPLFIKQGEKILVNTETNEYQERVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P39</accession>
    <name>Q73P39_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NeuB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971570.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682269.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0960"/>
    <dbReference type="EnsemblBacteria" id="AAS11451">
        <property type="protein sequence ID" value="AAS11451"/>
        <property type="gene ID" value="TDE_0960"/>
    </dbReference>
    <dbReference type="GeneID" id="2740768"/>
    <dbReference type="KEGG" id="tde:TDE_0960"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.924"/>
    <dbReference type="eggNOG" id="COG2089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040465_0_0_12"/>
    <dbReference type="OMA" id="YRHRVEF"/>
    <dbReference type="OrthoDB" id="674753at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006190">
        <property type="entry name" value="AFP_Neu5c_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036732">
        <property type="entry name" value="AFP_Neu5c_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51269">
        <property type="entry name" value="SSF51269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50844">
        <property type="entry name" value="AFP_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFP-like" evidence="1">
        <location>
            <begin position="316"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="379" mass="41864" checksum="71B0AA17204CEB62" modified="2004-07-05" version="1">MCGKYGYFKLGSEIFSVENPLTIAEIGTSHNGSIQKARNLIDVAAEAGAKAVKFQIVYADEILHPNTGYVDLPTGKIPLYDRFKSLELPVSFYKELAEYSRSKKLLFSASPFGFRSAEELAALKPDFIKIASPELNYVQLLKYCAGFNIPMILSSGVSILKDIEKAVSFLRSENKDLPLALLHCITSYPAPEKEYNVSVIKNLSRIFGIACGVSDHSLDPILVPALTLAAGGFIIEKHICLSRKEEGLDDPVALEPDMFKKMCSALNSFSKKTYDEIIEGLTKLNYSIELINEVIGSGEKKLSPAETKNYGRTNRSIHYLNDLKKGDVITDKDIAVLRTEKILSPGEAPEMFDSFIGAVLQRAVKSGEGLLMEDFLTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P75</accession>
    <name>Q73P75_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_0924</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.892"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC1_TM_sf"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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    </feature>
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            <begin position="192"/>
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            <begin position="310"/>
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            <begin position="52"/>
            <end position="321"/>
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        <location>
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    </feature>
    <feature type="binding site" evidence="6">
        <location>
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            <end position="424"/>
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        <ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
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            <dbReference type="PROSITE" id="PS50929"/>
        </source>
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            <dbReference type="EMBL" id="AAS11415.1"/>
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        </source>
    </evidence>
    <sequence length="627" mass="69890" checksum="BF09AC70DC1158FA" modified="2004-07-05" version="1"> </sequence>
</entry>
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        <name evidence="2" type="ordered locus">TDE_0917</name>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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        <property type="project" value="UniProtKB-KW"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS11408.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
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        <name evidence="1" type="ordered locus">TDE_0914</name>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
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                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
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            <dbReference type="PubMed" id="15064399"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="41" mass="5010" checksum="DFA103FCEE4C79BB" modified="2004-07-05" version="1">MRQTGRLPRKSLAGFIMRNLWSKYIFNFNKEIEYAIMLKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PA1</accession>
    <name>Q73PA1_TREDE</name>
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        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_002682184.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0898"/>
    <dbReference type="EnsemblBacteria" id="AAS11389">
        <property type="protein sequence ID" value="AAS11389"/>
        <property type="gene ID" value="TDE_0898"/>
    </dbReference>
    <dbReference type="GeneID" id="2739772"/>
    <dbReference type="KEGG" id="tde:TDE_0898"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.869"/>
    <dbReference type="eggNOG" id="ENOG5033R5J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1365131_0_0_12"/>
    <dbReference type="OrthoDB" id="1567357at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011733">
        <property type="entry name" value="CHP02185_IM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09605">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02185">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="199" mass="21747" checksum="C9543472A9BFB942" modified="2004-07-05" version="1">MNKKIGLKDIVLITLLTAIMIGIQTVVLMPFITNLKFVIWFVGGIDGVLCGIIYCLMIAKAPKLGTAFIFSFIFAVYYFFVNSMIIISAMIAGAGLVMELILWNNGYKNKIKATIAYVLFGLTIMLAPNVLIFLQKDAMIAGLQANGLTQEYIDSIFAVYSAENIGIGMLLTAIGSIAGTQIGYRLLNRYFISGGMVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PF2</accession>
    <name>Q73PF2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971457.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0847"/>
    <dbReference type="EnsemblBacteria" id="AAS11338">
        <property type="protein sequence ID" value="AAS11338"/>
        <property type="gene ID" value="TDE_0847"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0847"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.816"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105096_0_0_12"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="122" mass="14108" checksum="2B3B70D19AB13726" modified="2004-07-05" version="1">MSKCPIKCIDGCGACCVHFEPDVYEVEALYLASWLLFHQRERALQILEGRFNENVLDKKNGCLLFDIDNPYHCTVYDGRCLICRLFGYSGDHGKDRTVRWRPCKYLVSMDKNLSASTIKQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PH0</accession>
    <name>Q73PH0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">M18 family aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_0829</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971439.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682090.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0829"/>
    <dbReference type="EnsemblBacteria" id="AAS11320">
        <property type="protein sequence ID" value="AAS11320"/>
        <property type="gene ID" value="TDE_0829"/>
    </dbReference>
    <dbReference type="GeneID" id="2739513"/>
    <dbReference type="KEGG" id="tde:TDE_0829"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.798"/>
    <dbReference type="eggNOG" id="COG1362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019532_2_0_12"/>
    <dbReference type="OMA" id="KSGCHAI"/>
    <dbReference type="OrthoDB" id="304020at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="430" mass="47280" checksum="BB67FEB839C4F3E5" modified="2004-07-05" version="1">MKKAEALMKFIDKSPSVYHAIKNAGEFLEAKGFVHLNREDTFELKPQGRYFVTNNGSALIAWQMPKSGNAENGFRIVGSHSDSPTFRIKPNPEIKVNNHYLKLNTEGYGGVILSTWFDRPLSAAGRVIIKTGDLLKPEVKLINFDKNLLTIPSLAIHMNREINDGYKFNKQKDTLPLIALINEKLEEKGFLMNLIAEEAGVTVDKILDFDLYLYDRQPGCFIGANDEFFSVGRIDNLGMACASIDALGDALPSNFVQVAAIFDNEEVGSRTAQGAGSPFLHDTLQRIIVSTSKGNAFEELQKALAKSFLISADQAHALHPNYTEKNDITNFPLMNKGPAIKVAASMSYTTDGISAAIFRDICARAKVPCQNFVNRSDMAGGSTIGPISVSNLNIKSVDIGNPILGMHSVRELGGTEDQEYITKAFAEFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PJ4</accession>
    <name>Q73PJ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971415.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11296">
        <property type="protein sequence ID" value="AAS11296"/>
        <property type="gene ID" value="TDE_0805"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0805"/>
    <dbReference type="HOGENOM" id="CLU_3298093_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="40" mass="4879" checksum="187D2F15AF7FCEED" modified="2004-07-05" version="1">MLALIFTYLLHYGMLHIKQKASFLFHQLRSVHIIKNIFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PS5</accession>
    <name>Q73PS5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971333.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681957.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0721"/>
    <dbReference type="EnsemblBacteria" id="AAS11214">
        <property type="protein sequence ID" value="AAS11214"/>
        <property type="gene ID" value="TDE_0721"/>
    </dbReference>
    <dbReference type="GeneID" id="2740085"/>
    <dbReference type="KEGG" id="tde:TDE_0721"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.697"/>
    <dbReference type="HOGENOM" id="CLU_593040_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="461" mass="54668" checksum="238903126FC528EF" modified="2004-07-05" version="1">MKRIGLILIFFIFPCLIFTESRDWDVFFNERLSYSLSASLNDIEFKKIELLEYKEKTKWIPSLSFDFPKLFAWKNIPVELSGANSLIKTKYIDVFNGKYSLVLNQALPSAGNILFSFNFNYEYLLQSKEFKQIPSFTIQFSQPITKYSFGFVNEAKKISFLKKSVKEKRFALYADFIKIFLKSALNIEVLNAESVYLKNKYLYAAEQYSTAEIEFKKERLKLDALLQIKQKMIEAKQEYGLNLNSLNRLKEEFVLNYNYEYSLINEEDMSSLLEFLENLFLDSYIFDIQNTEYEIFLLNAEKEQAYIKNAPRFNIGFSHAPNTLKTRFSSYTASWQNLKQTEWLPELFISFSWTPDYTFTQKKEIDLIDLKISYAKNKLKTLKEKKEIKNKAKTLRIKNLKEDLHILSENLNLYLELNEEYKKLYKDGVITNLSLLEYTVNPSRQRLLKLKKLKDLIFEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PT7</accession>
    <name>Q73PT7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="6">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="6">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="6">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">msrA</name>
        <name evidence="8" type="ordered locus">TDE_0709</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2016" name="Biochemistry" volume="55" first="5117" last="5127">
            <title>Essential Role of the Linker Region in the Higher Catalytic Efficiency of a Bifunctional MsrA-MsrB Fusion Protein.</title>
            <authorList>
                <person name="Han A.R."/>
                <person name="Kim M.J."/>
                <person name="Kwak G.H."/>
                <person name="Son J."/>
                <person name="Hwang K.Y."/>
                <person name="Kim H.Y."/>
            </authorList>
            <dbReference type="PubMed" id="27551953"/>
            <dbReference type="DOI" id="10.1021/acs.biochem.6b00544"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971321.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="PDB" id="5FA9">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A/B=1-317"/>
    </dbReference>
    <dbReference type="PDBsum" id="5FA9"/>
    <dbReference type="SMR" id="Q73PT7"/>
    <dbReference type="STRING" id="243275.TDE_0709"/>
    <dbReference type="EnsemblBacteria" id="AAS11202">
        <property type="protein sequence ID" value="AAS11202"/>
        <property type="gene ID" value="TDE_0709"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0709"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.687"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_1_0_12"/>
    <dbReference type="OMA" id="GEFIPYI"/>
    <dbReference type="OrthoDB" id="1554384at2"/>
    <dbReference type="BRENDA" id="1.8.4.11">
        <property type="organism ID" value="6426"/>
    </dbReference>
    <dbReference type="BRENDA" id="1.8.4.12">
        <property type="organism ID" value="6426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="7">
        <location>
            <begin position="173"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="5FA9"/>
        </source>
    </evidence>
    <sequence length="317" mass="35822" checksum="4BD043AD794FCEFB" modified="2004-07-05" version="1">MIKEIYLAGGCFWGVEGYFRQIPGVKETDTGYANGKNDSANYKGLHQSDHAETVKIVYDSSVVSLQELLAHYFRIIDPTSLNKQGNDAGRQYRTGIYYVDDSMIKEINSFVKFMQKKYSRPIVVEVEKLKHFILAEDYHQDYLQKNPGGYCHIDLTLALKPLYDESKFKVPSKEELKKSLKPIQFSVTQEKATERPFTSEYDKFDAEGIYVDITTGKPLFSSLNKYDAGCGWPSFTKAITTQALQYLEDKSLGMNRTEVVSKTGGAHLGHVFDDGPADAGGLRYCINGAALRFIPYDKMEKEGYGDYLPYVKPTGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PX8</accession>
    <name>Q73PX8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeS assembly protein SufB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">sufB</name>
        <name evidence="3" type="ordered locus">TDE_0667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0051 (ycf24) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971280.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669913.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0667"/>
    <dbReference type="EnsemblBacteria" id="AAS11161">
        <property type="protein sequence ID" value="AAS11161"/>
        <property type="gene ID" value="TDE_0667"/>
    </dbReference>
    <dbReference type="GeneID" id="2739660"/>
    <dbReference type="KEGG" id="tde:TDE_0667"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.648"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_12"/>
    <dbReference type="OMA" id="YYSAPKQ"/>
    <dbReference type="OrthoDB" id="635721at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010231">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01980">
        <property type="entry name" value="sufB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufBD_N" evidence="2">
        <location>
            <begin position="157"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="488" mass="54681" checksum="5CE2F70E7D3B46D0" modified="2004-07-05" version="1">MSKAINQNTDKAPEDASLFQERKRTFVSDIERGVYDIKDSIDYKYSTGLGLNEEVVKKISARKKEPDWMLDLRLKSLAYFNERPMPDWGADISDLDIQEIIHYIVSDTKPLAETWDDVPEEIKKTFDRLGIPEAERSSLAGVGAQYDSEVVYHSLKEDLEKQGVVYLDMETAVHKYEDIVKKHFMQLIKPNDHKFAALHGAVWSGGSFVYVPKGVRVELPLQSYFRLNAQQSGQFEHTLIIVEEGAYLHFIEGCSAPKYYKNALHAGAVELYVGKKATLRYSTIENWSRNLYNLNTKRAIVEEDGAIEWVSGSFGSRVTMLYPMSILKGDRSRSEFTGVTFASEGQCLDTGTKTVHIGKNTVSEMRSRSIAKNGGEANYRGLLYIGANATGAKAAAECESLMLDDKSRSDTIPIIESHIDDVDIGHEAKIGRISESMVFYLMQRGLDEAAAKSLIIKGFVEPISKELPLEYAVELNNLITIELEGTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q23</accession>
    <name>Q73Q23_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971235.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681807.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0621"/>
    <dbReference type="EnsemblBacteria" id="AAS11116">
        <property type="protein sequence ID" value="AAS11116"/>
        <property type="gene ID" value="TDE_0621"/>
    </dbReference>
    <dbReference type="GeneID" id="2740466"/>
    <dbReference type="KEGG" id="tde:TDE_0621"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.599"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_1_12"/>
    <dbReference type="OMA" id="FYWRMVS"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="460" mass="50750" checksum="20EFA7D67D27FD36" modified="2004-07-05" version="1">MTVNSKPVVNLKSVFSDKSFLKNLFIIAVPIILQNFISSFVNILDTIMIGRLGTIELAAVGLGNQLFFLLNLILYGIGSGGMVFTAQFWGKKDFNGLQKTFALSLMVAVFFSAIFTLACTIFPKEILSLYSKDAAVIEKGVDYLGISAFCFLPFAVNFIFMITLRSIEKVRVAVGATLVSLFVNLILNAVLIFGLLGFPALGVKGAAIATVASRAAELIILFSVTKKKKYPILGKLKNHFDFDFKFIRQYFAIVMPVLINESLWSLGITFHHKIFAGIGTFAYAAYNITNTVSMLTWVIFIGFGNGVSVLIGKKIGERNYDEAKTYAAKVSIFVPFVAVFVGAMLIPISYLTPIFFNVETVVLQTVMKLFIILACCYPLKAFNMCMLVGIIRAGGDTRFGIICDTAVMWCVSIPLAYSLSVYTSIPAWGIYICLFSEEPFKALLGLWRIKSGKWLRSVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q51</accession>
    <name>Q73Q51_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Internalin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0593</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971207.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681765.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0593"/>
    <dbReference type="EnsemblBacteria" id="AAS11088">
        <property type="protein sequence ID" value="AAS11088"/>
        <property type="gene ID" value="TDE_0593"/>
    </dbReference>
    <dbReference type="GeneID" id="2741556"/>
    <dbReference type="KEGG" id="tde:TDE_0593"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.573"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479755_0_0_12"/>
    <dbReference type="OMA" id="SICKLEY"/>
    <dbReference type="OrthoDB" id="670569at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284649" evidence="3">
        <location>
            <begin position="22"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="631" mass="69201" checksum="BED81F8B1533D80B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QG5</accession>
    <name>Q73QG5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic nucleotide binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0478</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971092.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002665989.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0478"/>
    <dbReference type="EnsemblBacteria" id="AAS10973">
        <property type="protein sequence ID" value="AAS10973"/>
        <property type="gene ID" value="TDE_0478"/>
    </dbReference>
    <dbReference type="GeneID" id="2740525"/>
    <dbReference type="KEGG" id="tde:TDE_0478"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.463"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_4_1_12"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="145"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="216" mass="24493" checksum="53FB4AB9407064F3" modified="2004-07-05" version="1">MNPIFKNIPAQEAEKYLKNTKAKTLNYKKDAFIFFEGDTPAFFFVLKSGIVQIEKNTADGKRLIVNRFENPGTVFAEVYALLDSAIYDYSCRVISDAEILCLPIEGVFGAGAYSETHFKVLKNLLNILAHKAYFLNQKLLIFSSFSLRQKIALYLLQQAEGSSKVELNLNREAMAEYLAVPRPSLSRELMSMQKDGLLKIEKDTIIVNLDKLEDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QG6</accession>
    <name>Q73QG6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1858 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971091.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681571.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0477"/>
    <dbReference type="EnsemblBacteria" id="AAS10972">
        <property type="protein sequence ID" value="AAS10972"/>
        <property type="gene ID" value="TDE_0477"/>
    </dbReference>
    <dbReference type="GeneID" id="2740524"/>
    <dbReference type="KEGG" id="tde:TDE_0477"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.462"/>
    <dbReference type="eggNOG" id="COG1840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055408_0_0_12"/>
    <dbReference type="OMA" id="WIGWDYI"/>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015077">
        <property type="entry name" value="DUF1858"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08984">
        <property type="entry name" value="DUF1858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140683">
        <property type="entry name" value="SSF140683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1858" evidence="1">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="435" mass="49535" checksum="DF61C5639C34FA82" modified="2004-07-05" version="1">MNKYFNMDESVFDITERFPETIRYLAEKGFTPLTNPLMRKIMGKKISLEKALLTKNLDIGLCEKELIEVIEQNKNIGFAEIDLSLEKKNAQNTGYDDGKKNIRIEGVLPCPIRIPLLEAFKEFHSKYIEENKDELEKQNYKISYDLRSANLGIDWIIKEAQTGKKENLPDILLSAGFELFFDKKLMGSFIENKDFHCSIEKMNKDFCNDYIDLRDGKKNYAIIGVVPAVMIVNTELLRGRKMPETWADLLLPEFENSAAIPFSDLDLFNSVILNIYSRFGDEGIKKLGRACRTSLHPAQMVKGKASLVLKNPKSVVNEPPAVNISPYFFSKMIKEDSALKTVWPKDGAIAAPIFMLVKKENEALTKAFADFFLSEKTGRVFSESGFFPSTNPDVDNRLGEDKKFSWVGWDFIYQNDIGSLLEKIKTDFETAAGKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QJ2</accession>
    <name>ARCA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine deiminase</fullName>
            <shortName evidence="1">ADI</shortName>
            <ecNumber evidence="1">3.5.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginine dihydrolase</fullName>
            <shortName evidence="1">AD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">arcA</name>
        <name type="ordered locus">TDE_0451</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-arginine = L-citrulline + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="EC" id="3.5.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginine deiminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.6" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971065.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681549.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73QJ2"/>
    <dbReference type="SMR" id="Q73QJ2"/>
    <dbReference type="STRING" id="243275.TDE_0451"/>
    <dbReference type="EnsemblBacteria" id="AAS10946">
        <property type="protein sequence ID" value="AAS10946"/>
        <property type="gene ID" value="TDE_0451"/>
    </dbReference>
    <dbReference type="GeneID" id="2740748"/>
    <dbReference type="KEGG" id="tde:TDE_0451"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.438"/>
    <dbReference type="eggNOG" id="COG2235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052662_0_1_12"/>
    <dbReference type="OMA" id="ERATMHL"/>
    <dbReference type="OrthoDB" id="592329at2"/>
    <dbReference type="UniPathway" id="UPA00254">
        <property type="reaction ID" value="UER00364"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019547">
        <property type="term" value="P:arginine catabolic process to ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00242">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006356">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01078">
        <property type="entry name" value="arcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0056">Arginine metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000182253" description="Arginine deiminase">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="1">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00242"/>
        </source>
    </evidence>
    <sequence length="410" mass="46115" checksum="3909E398E8A99622" modified="2004-07-05" version="1">MAVINVTSEIGKLKKVLLHRPGKELLNLTPDKLDELLFDDIPFLKMAQKEHDAFADILSKNGVEVVYLEDLAAEAVSQSAEIREKFIKQYINEADIYSEYYQKMIYDFLNAIKDPKELILKTMEGVNANEIPFKNTHSLSHYVLDSGSMVINPMPNLYFTRDPFACIGNGVSLNKMYSVTRCRETIYGEYIFDHHPEYAGKVNRFYNRYDAPSIEGGDILNIGKDVLAIGLSQRTSANAIDSIANNIFDNETSPIKTVLAFQIPAIRAFMHLDTVFTQIDFDKFTIHPGILGPLRVFEITRGTKKGELNVKQIDSTLEKVLEKYTGAGKIELIQCAGGDKIAAEREQWNDGSNTLCISPGTIVVYERNDVTNEILNKKGLKVLEMPCGELSRGRGGPRCMSMPLLREDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QP2</accession>
    <name>Q73QP2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenylate/guanylate cyclase catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS10896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681429.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0401"/>
    <dbReference type="EnsemblBacteria" id="AAS10896">
        <property type="protein sequence ID" value="AAS10896"/>
        <property type="gene ID" value="TDE_0401"/>
    </dbReference>
    <dbReference type="GeneID" id="2739410"/>
    <dbReference type="KEGG" id="tde:TDE_0401"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.390"/>
    <dbReference type="eggNOG" id="COG2114">
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    <dbReference type="HOGENOM" id="CLU_354090_0_0_12"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:intracellular signal transduction"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
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        <property type="entry name" value="Guanylate_cyc"/>
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    </dbReference>
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        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="545"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="797" mass="91141" checksum="E89B4FA35C13CA9D" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QQ8</accession>
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        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0385</name>
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    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
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            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS10880.1"/>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.374"/>
    <dbReference type="eggNOG" id="COG2274">
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    </dbReference>
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    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="entry name" value="PTHR24223:SF271"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF90123"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="294"/>
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    </feature>
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            <end position="296"/>
        </location>
    </feature>
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        <location>
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            <end position="522"/>
        </location>
    </feature>
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            <end position="348"/>
        </location>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS10880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="522" mass="60426" checksum="28E66FEF0E63ACF1" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QT6</accession>
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            <fullName evidence="1">FMN_red domain-containing protein</fullName>
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        <name evidence="2" type="ordered locus">TDE_0357</name>
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    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS10852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_002681344.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0357"/>
    <dbReference type="EnsemblBacteria" id="AAS10852">
        <property type="protein sequence ID" value="AAS10852"/>
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    </dbReference>
    <dbReference type="GeneID" id="2740164"/>
    <dbReference type="KEGG" id="tde:TDE_0357"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.346"/>
    <dbReference type="eggNOG" id="COG0655">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050993_2_0_12"/>
    <dbReference type="OMA" id="FACKLKG"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
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    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="3"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="211" mass="24461" checksum="F848826F4CCEAF28" modified="2004-07-05" version="1">MKKILLLNASPRKNWNTAQILKSAMRGAQTAGAEVEYIDLYDLNFTGCRSCMLCKRKGVERCRCYWKDDLSPIIEKVFSADALFIGTPIYLGRPTSHYFAFMERLHFCSLSYDDYSNYFKGKVNVVLFLTMNATKDFYDKLYKEKFGNYANEFKSLNGNVTLYPCYNTLQVSDYSKFDMASFSEDKKKKSREECFPIDLENAFQLGKKLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QZ8</accession>
    <name>Q73QZ8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">gyrA</name>
        <name evidence="11" type="ordered locus">TDE_0295</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970909.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681235.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73QZ8"/>
    <dbReference type="STRING" id="243275.TDE_0295"/>
    <dbReference type="EnsemblBacteria" id="AAS10790">
        <property type="protein sequence ID" value="AAS10790"/>
        <property type="gene ID" value="TDE_0295"/>
    </dbReference>
    <dbReference type="GeneID" id="2740282"/>
    <dbReference type="KEGG" id="tde:TDE_0295"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.284"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_12"/>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="OrthoDB" id="217468at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="10">
        <location>
            <begin position="15"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="531"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS10790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="815" mass="90282" checksum="6BFEBE869A571416" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R51</accession>
    <name>Q73R51_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine reductase complex protein GrdC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grdC</name>
        <name evidence="3" type="ordered locus">TDE_0240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970856.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681153.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0240"/>
    <dbReference type="EnsemblBacteria" id="AAS10737">
        <property type="protein sequence ID" value="AAS10737"/>
        <property type="gene ID" value="TDE_0240"/>
    </dbReference>
    <dbReference type="GeneID" id="2739835"/>
    <dbReference type="KEGG" id="tde:TDE_0240"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.234"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027957_0_0_12"/>
    <dbReference type="OMA" id="DVRGFCA"/>
    <dbReference type="OrthoDB" id="336007at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045984">
        <property type="entry name" value="DUF5940"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017236">
        <property type="entry name" value="Gly/sarc/bet/_Rdtase_C_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19364">
        <property type="entry name" value="DUF5940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037559">
        <property type="entry name" value="Gly_sarc_betain_red_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="1">
        <location>
            <begin position="253"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5940" evidence="2">
        <location>
            <begin position="345"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="512" mass="54831" checksum="0ABFFB9375644F18" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R52</accession>
    <name>Q73R52_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycine reductase complex protein GrdD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">grdD</name>
        <name evidence="2" type="ordered locus">TDE_0239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS10736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0239"/>
    <dbReference type="EnsemblBacteria" id="AAS10736">
        <property type="protein sequence ID" value="AAS10736"/>
        <property type="gene ID" value="TDE_0239"/>
    </dbReference>
    <dbReference type="GeneID" id="2739834"/>
    <dbReference type="KEGG" id="tde:TDE_0239"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.233"/>
    <dbReference type="eggNOG" id="COG0416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1027861at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012116">
        <property type="entry name" value="Gly_reductase_pC_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036593">
        <property type="entry name" value="GrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR036593-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="384" mass="40177" checksum="FC20EA885599299E" modified="2004-07-05" version="1">MADKKQIADLFLGLAEGLEGGSFAGRFSVGLTIPGSEHGEAELVYAAELAAKRNPDLDVILIGGPEAKGLKHFPAATLEDAHKEMERLFKEGTIKACVTMHYNFPLGVSTVGKVVTPGKGREMILATTTGTTDANRYKAMLLNAIGGIAVAKASGIAEPTVGLLNIDGIAVIEKALNKMKEKGYKVNYTESNRADGGVRMRGNDLLQGTPDVMVCDTLTGNLLIKLFSSFVTGGSYEGSGFGYGPCIGSGYDDVVGIISRASGAPAIANALKFVADCAKNNVHGIYAEELKAAKKAGLDELLEDMPGAKPVAAAAAEEVKAPPKKTVDAGIPGIDVIEIEDACKALWKEGIYAETGMGCTGPVIMVSEEDLAKARDVLHKADYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R57</accession>
    <name>Q73R57_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding protein, HlyB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970850.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681147.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0234"/>
    <dbReference type="EnsemblBacteria" id="AAS10731">
        <property type="protein sequence ID" value="AAS10731"/>
        <property type="gene ID" value="TDE_0234"/>
    </dbReference>
    <dbReference type="GeneID" id="2739829"/>
    <dbReference type="KEGG" id="tde:TDE_0234"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.227"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OMA" id="QDFNRYE"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="23"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="345"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="603" mass="68856" checksum="A08378DADA4BBD2F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R80</accession>
    <name>Q73R80_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, permease protein, cysTW family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970827.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681110.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0211"/>
    <dbReference type="EnsemblBacteria" id="AAS10708">
        <property type="protein sequence ID" value="AAS10708"/>
        <property type="gene ID" value="TDE_0211"/>
    </dbReference>
    <dbReference type="GeneID" id="2739368"/>
    <dbReference type="KEGG" id="tde:TDE_0211"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.205"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_4_2_12"/>
    <dbReference type="OMA" id="LRWHPGY"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
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    </dbReference>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS10708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="243" mass="26926" checksum="44BF49E9917B8805" modified="2004-07-05" version="1">MMLSTIKQNKFKIGGAFFCLILWEIFAQGLKAPLIIPPIKEILSALFVIIKTPETYVFILSTLIRIFITLAIDSFIAFLLGIASGLNKNVEDFLSAPENILKSSPTISVLLLALIWFKSNMTPIFVTSLIVLPLLYRNIVDGVKNIDKGLIEMSYDFNVPFGKRLKSLYLPCIRPFLKNGYILSTGFAVKVVIMAEVLSQPKYGIGSAFQTAKIQIETASIFAWTGIAVLLAAFLQKGVKKIL</sequence>
</entry>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="102" mass="11256" checksum="E812E17577FA9DE8" modified="2004-07-05" version="1">MIGIFFTHKADGNKGSHLGGIEVTGIFCFISPDSEKTAETQNKKNISLTANLIREVFISTCIGLKKISFNLALHLRLKKCIIGPLINLTLSITVRRFCNYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="548" mass="63844" checksum="C2EE4C6CF0032C25" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RK2</accession>
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            <fullName evidence="1">PDDEXK_1 domain-containing protein</fullName>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
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                <person name="Weinstock G.M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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        <location>
            <begin position="646"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12705"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10584.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="945" mass="110398" checksum="9510630131B8AC4E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RM5</accession>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AAS10561">
        <property type="protein sequence ID" value="AAS10561"/>
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    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0063"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.64"/>
    <dbReference type="eggNOG" id="ENOG5033D6N">
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    <dbReference type="OMA" id="IIKGQWK"/>
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    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035196">
        <property type="entry name" value="DUF5312"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17239">
        <property type="entry name" value="DUF5312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="511" mass="59262" checksum="BBB40BA162D5B63B" modified="2004-07-05" version="1">MAHKKESFFQKIIGLFMSSESPEAVKRRKLKDIAKTIGKTRYSKWYKSSSQEVLPQAAQFFYSIYKVVGPARPLLAGAASSKVLKNVTVENSLSDKQRKLIENLSEESIIEQSKNTNAEVFAEKVKKELKTFIGELDSDQAQKIDLSYQHLDAFIQFVLFDYYFLLRKFDSNFIENNFNYTPNFQAIRGEYISEDLKDFASVFYQLSFDTDWNLIFDIIKTYKNIQPVHAGQWKKLLGALGDLRRSRALEYIIQHITEDIIYTVETTPFTEKVTDTYVSQIKTNTQNVIHKLIEEQRSSKVAVLINKIFGEQVISGMKNYVIDANRAFTRRGLSGYIYAEEMSYLKSFLIEYVKTDIRALCDLFLVRGNWGGFAGTTADFSNSFHAIMQVTSKTIEFDDKLSEVSDIGVKFRTLLSRMEREKEAGRQAAKLLNDVNETALKLINISLKHIIVIGNNFKTIIADYDKPRRELIQNWKEIEQNSERPVREWLVEAYKKIYDFTMLMQLFIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RT1</accession>
    <name>Q73RT1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970621.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673400.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0004"/>
    <dbReference type="EnsemblBacteria" id="AAS10502">
        <property type="protein sequence ID" value="AAS10502"/>
        <property type="gene ID" value="TDE_0004"/>
    </dbReference>
    <dbReference type="GeneID" id="2741618"/>
    <dbReference type="KEGG" id="tde:TDE_0004"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.5"/>
    <dbReference type="eggNOG" id="ENOG502ZB9V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095712_0_0_12"/>
    <dbReference type="OMA" id="MRIPCAS"/>
    <dbReference type="OrthoDB" id="1506157at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="224" mass="24543" checksum="D4E4FD0FEDBB55A3" modified="2004-07-05" version="1">MQDTQIEFGSYEKSIHRWGRTWMVIAIIMFLSYPLFTCIYYNTWPNFWLLLRGLFGVAVVFWPVGIIEAFTFAPMLGAGGTYVGFITGNLTNLKVPCGVLALETAKVEANTEEGDVVTTIAVAVSSITTTLILVLGMLLLTQLKPILESPIMAPAFKNILPALFGGLLVVFVAKNPKIAAVPFAFMLILFIAMPQLGKAISMLIPVGAAITIIYTRIMYKKGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>F7IVH0</accession>
    <name>F7IVH0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Flagellar motor switch protein FliG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fliG</name>
        <name evidence="14" type="ordered locus">TDE_1216</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FliG family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971823.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668469.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1216"/>
    <dbReference type="EnsemblBacteria" id="AAS11734">
        <property type="protein sequence ID" value="AAS11734"/>
        <property type="gene ID" value="TDE_1216"/>
    </dbReference>
    <dbReference type="GeneID" id="2740110"/>
    <dbReference type="KEGG" id="tde:TDE_1216"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1171"/>
    <dbReference type="eggNOG" id="COG1536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047835_1_1_12"/>
    <dbReference type="OMA" id="QVRPFEF"/>
    <dbReference type="OrthoDB" id="847822at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000090">
        <property type="entry name" value="Flg_Motor_Flig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023087">
        <property type="entry name" value="Flg_Motor_Flig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011002">
        <property type="entry name" value="FliG_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032779">
        <property type="entry name" value="FliG_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028263">
        <property type="entry name" value="FliG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30534">
        <property type="entry name" value="PTHR30534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01706">
        <property type="entry name" value="FliG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14841">
        <property type="entry name" value="FliG_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14842">
        <property type="entry name" value="FliG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003161">
        <property type="entry name" value="FliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00954">
        <property type="entry name" value="FLGMOTORFLIG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48029">
        <property type="entry name" value="SSF48029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00207">
        <property type="entry name" value="fliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6 10" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="7 10" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliG_N" evidence="13">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_M" evidence="12">
        <location>
            <begin position="131"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_C" evidence="11">
        <location>
            <begin position="233"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAS11734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="349" mass="39395" checksum="DE9A1C18963618E7" modified="2011-07-27" version="1">MAVAPAKERGSSKKGKDINSLTGRQKAAIFLVSLGGEISAKIMERLREDEVEKIVFEIARTETVEAELKDAVLQEFQDLMTAQNFITTGGIDYARDVLEKTFGSQKAIEIINRLTSSLQVRPFDFIRRTDPAHLLNFIQQEHPQTIALILAYLEPQKASVILQNLPDEIQSDVARRVATMDTTSPDVLREVERVLEKKLSTVSSEDYTAAGGVDSIVEILNLVDRSSEKSIIESLEDEDPDLAEEIKKKMFVFEDIVMLDDRSISKVLREVNNDEMAKALKQVDAEVQDKIFRNMSKRAGAMLRDEMEYMGPIRVKDVEEAQQKIVSIIRHLEDKGEIVIARSEEDELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>F7IW30</accession>
    <name>F7IW30_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Flagellar motor switch protein FliM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fliM</name>
        <name evidence="11" type="ordered locus">TDE_2763</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FliM family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973361.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666990.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2763"/>
    <dbReference type="EnsemblBacteria" id="AAS13280">
        <property type="protein sequence ID" value="AAS13280"/>
        <property type="gene ID" value="TDE_2763"/>
    </dbReference>
    <dbReference type="GeneID" id="2740730"/>
    <dbReference type="KEGG" id="tde:TDE_2763"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2607"/>
    <dbReference type="eggNOG" id="COG1868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052646_0_0_12"/>
    <dbReference type="OMA" id="NPQFTQI"/>
    <dbReference type="OrthoDB" id="1748746at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17908">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001689">
        <property type="entry name" value="Flag_FliM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02154">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002888">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00955">
        <property type="entry name" value="FLGMOTORFLIM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01397">
        <property type="entry name" value="fliM_switch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 9" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="6 9" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="10">
        <location>
            <begin position="253"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS13280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="344" mass="38454" checksum="64319056CC65A62B" modified="2011-07-27" version="1">MTEVLSQDEIDQLLTAISSGDTDTEDFRAVNDTRKIKIYDFKRPDKFSKEQMRTVQMMHETFARLTTTSLSAQLRSMAHVHVATVEQLTYEEFIRSIPTPTTLAIINMDPLRASALLEIDPSVTFSIIDRLFGGKGQGSKVQRELTEIESSVMEGVIVRILANMREAWTTVVDLRPRLGNIDTNPQFVQIVTPSEMVLLVTLETKVGEEEGMMNICLPYITLEPIISKLSTQFWFSSVRRASTGQYAAAIKDKLSTVEVDMVAEVGSLDVSIRDVLNLRAGDVVRLPNVRVGDPFKLTVGSRPKFSCQPGVKGKKLAVQILEKIEDISGDEFEELTSEGDELYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J40</accession>
    <name>Q73J40_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973334.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13253">
        <property type="protein sequence ID" value="AAS13253"/>
        <property type="gene ID" value="TDE_2736"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2736"/>
    <dbReference type="HOGENOM" id="CLU_3359080_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="36" mass="3984" checksum="60B9529C725D2612" modified="2004-07-05" version="1">MTPKKEKCGLRLRLKNPAGSRFGVYSVFFGLTGLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J72</accession>
    <name>Q73J72_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973302.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680747.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2704"/>
    <dbReference type="EnsemblBacteria" id="AAS13221">
        <property type="protein sequence ID" value="AAS13221"/>
        <property type="gene ID" value="TDE_2704"/>
    </dbReference>
    <dbReference type="GeneID" id="2739291"/>
    <dbReference type="KEGG" id="tde:TDE_2704"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2553"/>
    <dbReference type="eggNOG" id="COG1033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008861_1_1_12"/>
    <dbReference type="OMA" id="VHAVQDF"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="724"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="775"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="851"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="243"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="716"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS13221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="898" mass="99841" checksum="B988991419524B2A" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JA4</accession>
    <name>Q73JA4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4139 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973269.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2671"/>
    <dbReference type="EnsemblBacteria" id="AAS13188">
        <property type="protein sequence ID" value="AAS13188"/>
        <property type="gene ID" value="TDE_2671"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2671"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2523"/>
    <dbReference type="eggNOG" id="COG5316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025153_0_0_12"/>
    <dbReference type="OMA" id="WKTSYRI"/>
    <dbReference type="OrthoDB" id="541612at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4139" evidence="2">
        <location>
            <begin position="200"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="559"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="649" mass="73084" checksum="B06DE01C89E638D9" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JA8</accession>
    <name>Q73JA8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973265.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13184">
        <property type="protein sequence ID" value="AAS13184"/>
        <property type="gene ID" value="TDE_2667"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2667"/>
    <dbReference type="HOGENOM" id="CLU_3278175_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="41" mass="4551" checksum="E4DAB6A8E80B1ABD" modified="2004-07-05" version="1">MRLNSCRTVYPSSIISVNKKGASDIKQKPFGAPYLNLKNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JC8</accession>
    <name>Q73JC8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoate--protein ligase</fullName>
            <ecNumber evidence="4">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_2647</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973245.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676110.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2647"/>
    <dbReference type="EnsemblBacteria" id="AAS13164">
        <property type="protein sequence ID" value="AAS13164"/>
        <property type="gene ID" value="TDE_2647"/>
    </dbReference>
    <dbReference type="GeneID" id="2741092"/>
    <dbReference type="KEGG" id="tde:TDE_2647"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2502"/>
    <dbReference type="eggNOG" id="COG0095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_0_2_12"/>
    <dbReference type="OMA" id="RTCPEDD"/>
    <dbReference type="OrthoDB" id="871298at2"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="PTHR12561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="8">
        <location>
            <begin position="27"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS13164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="331" mass="37983" checksum="A840E2DFCB471F5A" modified="2004-07-05" version="1">MKYLETYSNDPEYNLAFEEYCFRHLPLENDEYFFLWQNGPAVIIGKNQNAYQEVNDDYVRGHNLKVVRRITGGGAVYHDLGNLNFSFVAKTKENQTIDFKRYYIPIINALEKIGVKAELSGRNDVTIDGQKCIGASQSVWQGRVLSNGCILFDVRLEELSKALNVRKEKLESKGVKSVRARVTNIKPHLKRDISVLDFKAELLKAIFELEGQEPVEYKLSASELEGVKKIYAERFSLKEWNYGASPKAEYSHYERFPIGSIEVFFNVKNAKISGLKIHGDFFGTEDVAEIEKLLEGCEYEKNAVSTKLAEIDLKAYFGAIEKDEFIEMFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JJ1</accession>
    <name>Q73JJ1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">secE</name>
        <name evidence="8" type="ordered locus">TDE_2427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973026.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667596.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2427"/>
    <dbReference type="EnsemblBacteria" id="AAS12945">
        <property type="protein sequence ID" value="AAS12945"/>
        <property type="gene ID" value="TDE_2427"/>
    </dbReference>
    <dbReference type="GeneID" id="2739852"/>
    <dbReference type="KEGG" id="tde:TDE_2427"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2294"/>
    <dbReference type="HOGENOM" id="CLU_113663_8_0_12"/>
    <dbReference type="OMA" id="WKECIGE"/>
    <dbReference type="OrthoDB" id="1974284at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="59" mass="6405" checksum="801F5276E823E11C" modified="2004-07-05" version="1">MAKIGTFWKECIGELRKVVWPTASEVGSSVKVVLISTLIVAVFLGGLDAFFIACVGWIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JJ5</accession>
    <name>RL10_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplJ</name>
        <name type="ordered locus">TDE_2423</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973022.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680363.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JJ5"/>
    <dbReference type="SMR" id="Q73JJ5"/>
    <dbReference type="STRING" id="243275.TDE_2423"/>
    <dbReference type="EnsemblBacteria" id="AAS12941">
        <property type="protein sequence ID" value="AAS12941"/>
        <property type="gene ID" value="TDE_2423"/>
    </dbReference>
    <dbReference type="GeneID" id="2739848"/>
    <dbReference type="KEGG" id="tde:TDE_2423"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2290"/>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092227_1_2_12"/>
    <dbReference type="OMA" id="VRDQKQA"/>
    <dbReference type="OrthoDB" id="1470978at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000154738" description="50S ribosomal protein L10">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="205" mass="22095" checksum="704E59650D124AE6" modified="2004-07-05" version="1">MALRTKNPNRQKTEAIESIKNDVKASSAFIFTEYRGLKVEQITELRKKLRENACTYKVVRNNFARIAFEDADIKDVDSWLTGPTALAMIAEDANLAAKTLFEYAKDAPALVIKGAVVDGEIYDAKQIEAFSKLPGKKDLIAMFMSTVNATTSKFVRTLQAIVDKGGAQGAAPAEAKAEAPASEEKAADTPAEQPAESAPEAAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JL5</accession>
    <name>Q73JL5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973002.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680333.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2403"/>
    <dbReference type="EnsemblBacteria" id="AAS12921">
        <property type="protein sequence ID" value="AAS12921"/>
        <property type="gene ID" value="TDE_2403"/>
    </dbReference>
    <dbReference type="GeneID" id="2740705"/>
    <dbReference type="KEGG" id="tde:TDE_2403"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2269"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_3_12"/>
    <dbReference type="OMA" id="GAWGTNC"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="213" mass="23859" checksum="FA63231AEA69FEE8" modified="2004-07-05" version="1">MEITEIYTGPLFVKTWALPLDKKTVLLVDPGGTDEELMEYLKNKNAERLEIMLTHGHFDHVGGVPELMLKYPDSSLWIHPADAGYLGKNGKEKHIACFSQIRAERYIKALKYDFPEPTALLKDGDIVNGFKVLYTPGHTEGSVCFWNEEAKVLFSGDTLFYRSHGRTDLLGGDDQKMKASLKSLLNLPDDTTVYPGHGSNTSIGAERGWIEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JV3</accession>
    <name>Q73JV3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973106.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680475.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2508"/>
    <dbReference type="EnsemblBacteria" id="AAS13025">
        <property type="protein sequence ID" value="AAS13025"/>
        <property type="gene ID" value="TDE_2508"/>
    </dbReference>
    <dbReference type="GeneID" id="2739020"/>
    <dbReference type="KEGG" id="tde:TDE_2508"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2374"/>
    <dbReference type="eggNOG" id="ENOG5032K9P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_601203_0_0_12"/>
    <dbReference type="OrthoDB" id="2114416at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900191">
        <property type="term" value="P:negative regulation of single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030155">
        <property type="term" value="P:regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284561" evidence="1">
        <location>
            <begin position="23"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="455" mass="50708" checksum="9B6F6C73782BA175" modified="2004-07-05" version="1">MKIQKKLFIFAVLLMTASLVFAQISMTSYSTQNLFGTDVDDFMNVNEWQNVQPKNIFGFLGYGKTGKGSINLGLAHQFKPFYLGTYFEGQLNGWEKKKEANGNITTYIPAGTASKSNGKLLFGFGNIGIMTDVSYKPDQNKKTEWTEATKTKQTDNLFNLDFNLIAGINLNSNNKLFKISAKLGLESDVGKKTTKVDSKLTKFEDKSKYNLVINAGFSHDFSSKDGITQTVLADLDTKWGIWPTKREVNVVGGVTTTDYKYGELKDILRLTPKYRIAYEPEGKFAFKAEAGLGIGFDFENDYNYTRTVVSSGGDTKAYNAARTYKTTLSLQPELKAAFVYAPVSKFKLNFGLGFNVPSVNWAFEKTETRDASGNVTNTAKGNTLTFNTNDGKFSADSGFTWLITENVIFDANWNIVNNLLKTFSTNLTEGDGINFWNTVNKLVVHNIKFALSVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JV6</accession>
    <name>Q73JV6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973103.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680473.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2505"/>
    <dbReference type="EnsemblBacteria" id="AAS13022">
        <property type="protein sequence ID" value="AAS13022"/>
        <property type="gene ID" value="TDE_2505"/>
    </dbReference>
    <dbReference type="GeneID" id="2741478"/>
    <dbReference type="KEGG" id="tde:TDE_2505"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2372"/>
    <dbReference type="eggNOG" id="ENOG5031CJY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1947874_0_0_12"/>
    <dbReference type="OrthoDB" id="1953572at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="138" mass="15969" checksum="96C45DE1F7CB41C3" modified="2004-07-05" version="1">MDTMEKFYSDASRLVEKSHANQLAEKLNKDGDTAAFDARLTEIFCKAVSLYDKQAQVLANDFADYWLSAYSEGRQKKEDAVEWFYQIFSLIAGNFEKDMDFPQEDWEQINLIISSEAESLDMDLLNSIMTVIVERKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K46</accession>
    <name>Q73K46_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972975.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2376"/>
    <dbReference type="EnsemblBacteria" id="AAS12894">
        <property type="protein sequence ID" value="AAS12894"/>
        <property type="gene ID" value="TDE_2376"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2376"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2244"/>
    <dbReference type="eggNOG" id="COG0001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082735_0_0_12"/>
    <dbReference type="OMA" id="PWEKEEG"/>
    <dbReference type="OrthoDB" id="1857059at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="288" mass="33615" checksum="6B7E452471898F42" modified="2004-07-05" version="1">MMNFYDEIRNRYGNVKRARGFYLYTEKNIRLLDMYLDGGMSILGRRENQAPLIFKQSIDKGLNAFLPSSGDYRLKKALNSLFPEHPHFYLLSEWSKAFSFLEIENNKTALDSYIMENTWKPFLPSSENLKKKKVFFVNPPFCTSIKIAVSKDDLPILSCAVSAAEKEVLAKAFFDLIRLINLRELENRLSDEELINSARGKNKKQQLAKNIKSYKRVTELCSHFWNMEGPYLFSKLNEEKYECFFKAALDSHILLSPDFTIPSILPKIRVYTELENFLKTQTQNVRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K97</accession>
    <name>Q73K97_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flagellar protein FliL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_2322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Controls the rotational direction of flagella during chemotaxis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliL family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972922.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2322"/>
    <dbReference type="EnsemblBacteria" id="AAS12841">
        <property type="protein sequence ID" value="AAS12841"/>
        <property type="gene ID" value="TDE_2322"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2322"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2191"/>
    <dbReference type="eggNOG" id="COG1580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136268_1_0_12"/>
    <dbReference type="OMA" id="YTMPENE"/>
    <dbReference type="OrthoDB" id="1921231at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
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    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="158" mass="18517" checksum="DBC9C7F8EF578A03" modified="2004-07-05" version="1">MSMLKNNRKSLKLYKFLKYVLFAVVLIIIVGSVFSLFKKKNTDEVLRSESPSEIRGKKALYSDLGRLRIPTADIHTGTLVVFPVLEYNSEDKAFEEELVQKKEDIRKSLIDWFSQKTVYELYTMPENEVKKEVLAEINSILNLSRIKRIYFKDFVILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KA0</accession>
    <name>Q73KA0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972919.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680232.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2319"/>
    <dbReference type="EnsemblBacteria" id="AAS12838">
        <property type="protein sequence ID" value="AAS12838"/>
        <property type="gene ID" value="TDE_2319"/>
    </dbReference>
    <dbReference type="GeneID" id="2739414"/>
    <dbReference type="KEGG" id="tde:TDE_2319"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2188"/>
    <dbReference type="eggNOG" id="ENOG5031CRX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141081_0_0_12"/>
    <dbReference type="OMA" id="TCNEAIN"/>
    <dbReference type="OrthoDB" id="2032307at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="161" mass="18441" checksum="36D7B217B5447F0A" modified="2004-07-05" version="1">MTCNEAINRYMILDKHETVPFAVTFHLLRCKKCRSLVRALTQASNLYTSSFQTKADDALTEKTMVKIQAAIPNLLSLQAEKYRLPNVSILPWAVVGILMIVGLAYMPFTEIGKWAAENFKLRFVIPFALVFSVFVSVYSAIFVYRNLDFFVKKFDLKKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KC2</accession>
    <name>Q73KC2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972896.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680210.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73KC2"/>
    <dbReference type="STRING" id="243275.TDE_2296"/>
    <dbReference type="EnsemblBacteria" id="AAS12815">
        <property type="protein sequence ID" value="AAS12815"/>
        <property type="gene ID" value="TDE_2296"/>
    </dbReference>
    <dbReference type="GeneID" id="2740261"/>
    <dbReference type="KEGG" id="tde:TDE_2296"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2166"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025265_0_0_12"/>
    <dbReference type="OMA" id="FKWALNS"/>
    <dbReference type="OrthoDB" id="81633at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284904" description="VWFA domain-containing protein" evidence="4">
        <location>
            <begin position="25"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="3">
        <location>
            <begin position="228"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="5">
        <location>
            <begin position="470"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="684" mass="75094" checksum="4F3E8A96A8DD22FF" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KI7</accession>
    <name>Q73KI7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Internalin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972831.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680084.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73KI7"/>
    <dbReference type="STRING" id="243275.TDE_2231"/>
    <dbReference type="EnsemblBacteria" id="AAS12750">
        <property type="protein sequence ID" value="AAS12750"/>
        <property type="gene ID" value="TDE_2231"/>
    </dbReference>
    <dbReference type="GeneID" id="2741336"/>
    <dbReference type="KEGG" id="tde:TDE_2231"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2107"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1019200_0_0_12"/>
    <dbReference type="OMA" id="NLKELAC"/>
    <dbReference type="OrthoDB" id="1265119at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="273" mass="29946" checksum="A28BEFB284BB42BA" modified="2004-07-05" version="1">METSTIIDGGTSFVIDSEKKTITIYVKTADGSSVKAEGCTETVIESGTESTLNIKSSLIILKGNIIEFNCGGDPYTYGNQIKSLNVQGLKNLEKLNCSGNRLTELNIEGLNNLKELACRYNRLSSLDVAHLPALEFLWCTANLLTDLNLTGMSSLKRLGCNNNKLEVLNLEGLTSLEHLWCGNNLLNKLNLTDLKSLTGLNCEKNKLTELDLTGLTALEHLWCSKNLLTKLNLTKALHLQSLDCSSNMLTELNTEELNDLQYLNSSGNCLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KJ0</accession>
    <name>Q73KJ0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminoacyl-histidine dipeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972828.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680081.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2228"/>
    <dbReference type="EnsemblBacteria" id="AAS12747">
        <property type="protein sequence ID" value="AAS12747"/>
        <property type="gene ID" value="TDE_2228"/>
    </dbReference>
    <dbReference type="GeneID" id="2741333"/>
    <dbReference type="KEGG" id="tde:TDE_2228"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2104"/>
    <dbReference type="eggNOG" id="COG2195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028526_0_0_12"/>
    <dbReference type="OMA" id="KGGYPGW"/>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03890">
        <property type="entry name" value="M20_pepD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001160">
        <property type="entry name" value="Peptidase_M20C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43501">
        <property type="entry name" value="PTHR43501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016599">
        <property type="entry name" value="Xaa-His_dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00934">
        <property type="entry name" value="XHISDIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01893">
        <property type="entry name" value="aa-his-dipept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="208"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="481" mass="52992" checksum="AA37B167532ACD76" modified="2004-07-05" version="1">MNPLQNTEPKEVFKWFYEISQVPRGSGNERAISDFLVKFAKDRNLEVHQDKAMNVIIKKPGTAGYEKSPTVIIQGHMDMVCEKDASSNHDFLKDPIKFVVKGEMLYADKTTLGGDDGIAVAYALTVLDSKDIPHPPLEVLITTEEETGMGGAMALTDEHLQGTRLLNIDSEEEGVFLVSCAGGSNINIFFDIKKEAAKGTFLKITVGGLLGGHSGIEINKQRANSIKLLGRILYNIKQNEKINIVEISGGSKHNAIAKDAHAVIAVENKEAVLKIVEKLAADFKGEYRAVDKLLTVTANETQNSSGQMFTKELTLNLIDFMASIPNGVQYMSMEIHGLVQTSLNNGVLEEIDGRIKFTTSVRSSVKSALDEIVDILRIQAERCGAEFKKVSEYPAWEYSPDSPVRDAAVNVYKKLNKKEPVITAIHAGLECGLLKKTLPNVDAVSFGPNLYDVHTPNEHMDIASVERVWKFLLAYLAELKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KM7</accession>
    <name>Q73KM7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">recJ</name>
        <name evidence="9" type="ordered locus">TDE_2190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972791.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680035.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2190"/>
    <dbReference type="EnsemblBacteria" id="AAS12710">
        <property type="protein sequence ID" value="AAS12710"/>
        <property type="gene ID" value="TDE_2190"/>
    </dbReference>
    <dbReference type="GeneID" id="2740212"/>
    <dbReference type="KEGG" id="tde:TDE_2190"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2067"/>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009736_5_2_12"/>
    <dbReference type="OMA" id="FIICDHH"/>
    <dbReference type="OrthoDB" id="491634at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="77"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="455"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="594"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="710" mass="79928" checksum="38DBCC6E174D12D4" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KN6</accession>
    <name>Q73KN6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAP2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972782.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680028.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2181"/>
    <dbReference type="EnsemblBacteria" id="AAS12701">
        <property type="protein sequence ID" value="AAS12701"/>
        <property type="gene ID" value="TDE_2181"/>
    </dbReference>
    <dbReference type="GeneID" id="2740203"/>
    <dbReference type="KEGG" id="tde:TDE_2181"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2058"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068892_1_1_12"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="64"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="346" mass="38328" checksum="7CC63ECA7EA8D165" modified="2004-07-05" version="1">MAELSAASKELHAVHQWGIEVIRTVQNFSSPFLNEIMKIFTDASTYGFVVFIVGLYLWCIDYKKGLHLAYAAAFTSGLNGGIKRILKIPRPFTHAPEIMLKSIGGFSTPSGHSSISAFIYPAVLFYKPFRENLSKDSQSAKSQKSGSASGKLKIAAAIILPLLVGFSRVYLGVHYPTDVLLGWGLGAFIFLSMMFFLPAIEAKLSTLNRTDEGDAKNIKFKKTASIRFTLAAFFSFILIFISREKVTEAGAILGLAFGNIRIFENSKYSFDASSGTWVQKLLRFIIGSALSCIPILIFYLLKIDSSYAQYRLYRFLEFFMIGLIASGLAPIIFCLLKISGEDNADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KT7</accession>
    <name>Q73KT7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972731.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679947.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2130"/>
    <dbReference type="EnsemblBacteria" id="AAS12650">
        <property type="protein sequence ID" value="AAS12650"/>
        <property type="gene ID" value="TDE_2130"/>
    </dbReference>
    <dbReference type="GeneID" id="2739389"/>
    <dbReference type="KEGG" id="tde:TDE_2130"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2012"/>
    <dbReference type="HOGENOM" id="CLU_1642961_0_0_12"/>
    <dbReference type="OrthoDB" id="2145486at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="161" mass="17530" checksum="24ACA76CEAB35B16" modified="2004-07-05" version="1">MKKYTLILLFLFVVSFAAFSHAMFLELVEPGVFQVEYDGGGFTPGTKVILYSDGGLDVIQEGVVDDKGFYRFDPSLKVMSAEASDGAGHVAYWEASEEESSDEGGTAASASGDSSAKSKKIGKTKRPSKLPTILTVLNTCAIIFLFFEFRTFKKKVLDKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KY9</accession>
    <name>Q73KY9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972679.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679876.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2078"/>
    <dbReference type="EnsemblBacteria" id="AAS12590">
        <property type="protein sequence ID" value="AAS12590"/>
        <property type="gene ID" value="TDE_2078"/>
    </dbReference>
    <dbReference type="GeneID" id="2741205"/>
    <dbReference type="KEGG" id="tde:TDE_2078"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1963"/>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105450_0_0_12"/>
    <dbReference type="OMA" id="DDASIWF"/>
    <dbReference type="OrthoDB" id="1444515at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="242" mass="27282" checksum="5825E5E3FD834080" modified="2004-07-05" version="1">MVLEENKDLAQKINDFLAQYRKIVLGIVVCILVAVAGIIVWFVIGENSKKTSVTSVEKVIYELEDFKREDRAKNPSSEDDAENNEKTVSAAVKEAEDKAIEELKTLGSKYSSSYAGFRANTTIAEIYFQRKMYEDALKFYELAAKAVKNSYVEGVASFNAAACADELGDKEKALAYYERASKVENFPLIPRALFNTGRLYEALSKKEDAILSYNRLLEKYPQNEWALLAKSRIIVLKGNDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KZ4</accession>
    <name>Q73KZ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972674.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679870.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2073"/>
    <dbReference type="EnsemblBacteria" id="AAS12585">
        <property type="protein sequence ID" value="AAS12585"/>
        <property type="gene ID" value="TDE_2073"/>
    </dbReference>
    <dbReference type="GeneID" id="2741200"/>
    <dbReference type="KEGG" id="tde:TDE_2073"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1958"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003728_2_5_12"/>
    <dbReference type="OMA" id="IEIWEQY"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="417" mass="48588" checksum="6D539335661E4A56" modified="2004-07-05" version="1">MSDIKHEKKLANMDTPGETTKSFENKLDEEIPDIEESDFINSPPFSDEIFSPEDSKQVEISELSKQAYSLLKGNSITEAINVFKKILELDPTNNYALVGLGDAERKNNKFNEAIKFYKQCLEHHPSNNYALFGLADCYKSMNQFPRAIAIWEEYLKFDDKNITVLTRVADAYRKTKEFEKAEKLYQKVLEKSPKNAYALIGLGHLNYDFKKYREALVYWEKVMESSGELVDIRILTSIGNCYRKMKLFDRGVYYFERALERSPDNFYGLFGLADCYRGLNQQYNSIVYWKKILELDPNNKVILTRIGDAYRSMNDFEKAKESYQKALDIDFDSYAMLGLAILCKLQQKYDQAITTLTHLKDTGDTNYNYRVYLELAQCYIEKKEKQKAIETLIDFQKLGIKNQTVSDLLFELTKNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L20</accession>
    <name>Q73L20_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972648.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668331.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2045"/>
    <dbReference type="EnsemblBacteria" id="AAS12559">
        <property type="protein sequence ID" value="AAS12559"/>
        <property type="gene ID" value="TDE_2045"/>
    </dbReference>
    <dbReference type="GeneID" id="2740639"/>
    <dbReference type="KEGG" id="tde:TDE_2045"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1930"/>
    <dbReference type="eggNOG" id="ENOG5031GKJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2222061_0_0_12"/>
    <dbReference type="OrthoDB" id="2008952at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="106" mass="11651" checksum="6D227AC6416E86C4" modified="2004-07-05" version="1">MICIVCKSEFLAADIRAICLSHVNETIKILPQSLLLHTLTNEDVRLVFFDSSLFTDTASFRKKSPHTQFVVISSIGDEGLAEKALICGASDFLLCPFTEKGVTICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L22</accession>
    <name>Q73L22_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal recognition particle-docking protein FtsY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsY</name>
        <name evidence="6" type="ordered locus">TDE_2043</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972646.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668333.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2043"/>
    <dbReference type="EnsemblBacteria" id="AAS12557">
        <property type="protein sequence ID" value="AAS12557"/>
        <property type="gene ID" value="TDE_2043"/>
    </dbReference>
    <dbReference type="GeneID" id="2740637"/>
    <dbReference type="KEGG" id="tde:TDE_2043"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1928"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_3_4_12"/>
    <dbReference type="OMA" id="AYNTIEA"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="5">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="292" mass="31565" checksum="9159C0D2E8EC3D93" modified="2004-07-05" version="1">MKNKSFAAGLKKLFGLYKGPEESFFEDLTDTLIEGDIGAKTALEIEASLRELCKKEKLVSEDDVLNGLYNILLPYVKVTSLIPEKDKVSIYLVLGVNGVGKTTSIGKMAHYYKEKYGTPIILAAGDTFRAAAIEQLKFHGEKNDVRVVAHQHGGDPGAVIFDAGDAMASSGGGLVLADTAGRLHNKDNLVRELQKIDRIAKTKASEGCYKKILVLDATTGQNGLRQAEVFHEAIGVDAVFLTKYDSTAKGGVAVTAGKELNLPMLFVGTGEKYENISPFSAENYVKEFIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L40</accession>
    <name>Q73L40_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972628.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2025"/>
    <dbReference type="EnsemblBacteria" id="AAS12539">
        <property type="protein sequence ID" value="AAS12539"/>
        <property type="gene ID" value="TDE_2025"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2025"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1911"/>
    <dbReference type="HOGENOM" id="CLU_153955_1_0_12"/>
    <dbReference type="OrthoDB" id="2152681at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="121" mass="13638" checksum="F7E51E7E730144E6" modified="2004-07-05" version="1">MKTKLCIYSQPNYLSRTAIEAEILFAVRLSKKQALTGGKSLACEERCSKKIGAVLVQQADRRSFEASAVPILVYFYILCNNKSYKEPSGFLRAEPLSSSFEDRRVVGEGRNFYLTKVSFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L62</accession>
    <name>Q73L62_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Internalin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972606.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679758.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2003"/>
    <dbReference type="EnsemblBacteria" id="AAS12517">
        <property type="protein sequence ID" value="AAS12517"/>
        <property type="gene ID" value="TDE_2003"/>
    </dbReference>
    <dbReference type="GeneID" id="2740456"/>
    <dbReference type="KEGG" id="tde:TDE_2003"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1892"/>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032128_1_1_12"/>
    <dbReference type="OMA" id="CFSNQLT"/>
    <dbReference type="OrthoDB" id="748974at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285953" evidence="3">
        <location>
            <begin position="24"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="424" mass="46312" checksum="3F3E311C03D246E8" modified="2004-07-05" version="1">MMEESKKLFITILLAAGLLTAVAATENAGRAVLGISPHEKEITVTAVTADGSPVQVEGCTVTEFPSGEETVLTATGTKVVLKGALIELFCYANKLTALDVRGLTALQELYCQDNMLTSLDIRELTGLHTLYCGNNRLTALDIRGLTALRKLYCNSNEIASLDVRGLTALQTLYCDNNRLSSLDVRHLTALQWLDCHFNKLTSLDVQGLPALQVLECSDNQLTLLDVQGLPALQKLYCQDNKITSLDVRGLTSLQVLMCYDNRLTALNVRRLTALQELNCSSNAIASIDVRGLTALQVLYCDNNRLTSLDVQGLTALQELACSDNQLTALNVQGLPALQALGFQDNRLEEDALIRILNSLPDRKTDEEGLAVLYSEGEKLPKESGSAVPASAEFRAAFKAAKQKNWKLYMQTEDGDGTEIRLQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L81</accession>
    <name>Q73L81_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972587.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957119.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1984"/>
    <dbReference type="EnsemblBacteria" id="AAS12498">
        <property type="protein sequence ID" value="AAS12498"/>
        <property type="gene ID" value="TDE_1984"/>
    </dbReference>
    <dbReference type="GeneID" id="2740437"/>
    <dbReference type="KEGG" id="tde:TDE_1984"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1873"/>
    <dbReference type="eggNOG" id="ENOG502ZQUE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703863_0_0_12"/>
    <dbReference type="OMA" id="CANANFV"/>
    <dbReference type="OrthoDB" id="1598907at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284925" evidence="1">
        <location>
            <begin position="27"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="403" mass="46080" checksum="EBFB706C482A0399" modified="2004-07-05" version="1">MEDKRIFTRNLVILFLLLLFPLGAFAQKVEDKNQNAEKNNEVKKNYIIETEGKKAVFYQTLSWENVEGILHFEFELEKKEKNGKWVIIDKKKLKKNSLDVSLPAGKYRYRIKVINLLGQVDAVSADRYFDILVAYQPETSSVSPAAIYFDEEYSDVVSLSGKNFREETTFALQKEGGAPIFGKIVEISPDGTKAKISFNMLRINPGQYEFVVTDPSGLKDSKQKMTFKFQKPIDIYLSGGYAFNGFAGNKLFKEYFGKNFAALSGILRFSFVPIKRSYGNFGFNFTGSGMYLRKKDSDYTLSAGLLLTGIQAVYMKPIIRHRLNFDAHLGFGTAFVVNTQFVFPEFKSPKSWYWGLTMNLGTALQVYVYKKLYIEVNLDHIIPFRTGFPKYIVQPSLSVGWEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L84</accession>
    <name>Q73L84_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972584.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1981"/>
    <dbReference type="EnsemblBacteria" id="AAS12495">
        <property type="protein sequence ID" value="AAS12495"/>
        <property type="gene ID" value="TDE_1981"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1981"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1870"/>
    <dbReference type="eggNOG" id="ENOG5031DU0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2132407_0_0_12"/>
    <dbReference type="OrthoDB" id="2189432at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="113" mass="13315" checksum="45E10558CE80503E" modified="2004-07-05" version="1">MSSRSTSQMNFFLIYYFFQIFSINIMGRYDKQFGRNSASLFICRVCLSANVALLYMLFHFVAKARKKLFSQIYLLSAFADTMKNFLTEQSRKALIFAAKSFYRENVKKIGEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LC7</accession>
    <name>Q73LC7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transposase_31 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rpn/YhgA-like nuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972541.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679655.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1938"/>
    <dbReference type="EnsemblBacteria" id="AAS12452">
        <property type="protein sequence ID" value="AAS12452"/>
        <property type="gene ID" value="TDE_1938"/>
    </dbReference>
    <dbReference type="GeneID" id="2740178"/>
    <dbReference type="KEGG" id="tde:TDE_1938"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1831"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068216_0_1_12"/>
    <dbReference type="OMA" id="MSANREY"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="67"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="288" mass="33348" checksum="7EC93A43A9D9D9BF" modified="2004-07-05" version="1">MSMSNRKYKDSVFVDLFSEDEKAKENFLSLYNALHGTNLPLSSPVENIRLENVMYMNIINDVSCLVDGKIIILAEHQSTINENMPLRFLEYIARLYEKLQAPTDRYLRKLSKIPTPEFYVFYNGKEDYPETTTLKLSDAFITKPESIPLELTVQVLNINTDKANKILTACKPLEEYSLFVEEVRNQTQLDPENGFTNAVKICIEKGILKEYLQRKSREVINMLVAEYDYDTDIAVQRSEERQIAFAQGEEKGTYQTKLETAKLMKEENCEISFIQKMTGLSKEEIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LJ4</accession>
    <name>Q73LJ4_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12383.1"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1868"/>
    <dbReference type="EnsemblBacteria" id="AAS12383">
        <property type="protein sequence ID" value="AAS12383"/>
        <property type="gene ID" value="TDE_1868"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1868"/>
    <dbReference type="HOGENOM" id="CLU_3376603_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="34" mass="4187" checksum="76D1F133F07D2A17" modified="2004-07-05" version="1">MSFQKLKKKHFQDNYLNLYKAKIIMLIIPSKKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LK0</accession>
    <name>Q73LK0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1862"/>
    <dbReference type="DNASU" id="2740051"/>
    <dbReference type="EnsemblBacteria" id="AAS12377">
        <property type="protein sequence ID" value="AAS12377"/>
        <property type="gene ID" value="TDE_1862"/>
    </dbReference>
    <dbReference type="GeneID" id="2740051"/>
    <dbReference type="KEGG" id="tde:TDE_1862"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1767"/>
    <dbReference type="eggNOG" id="ENOG5032VZ1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_876995_0_0_12"/>
    <dbReference type="OMA" id="NTEIHIG"/>
    <dbReference type="OrthoDB" id="1872559at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="103"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="323" mass="35870" checksum="E4B568B22E1DA53F" modified="2004-07-05" version="1">MKKIGKTILIILLGLMLVGIGYSLGGRFFYRSRRRIRERNFIDRTYNKIMSAAESMEDGIEDMENNLESWGDDMNEYFGDEYEKAETISLDGIKNFFLKAEVGEVKIEISDRADEASYKIQRINPKYFDVEKKGDTISFEDNTPSKFFKNLGFNFKNNSPKIYISLPRNIVFNNFEIKSGVGELDIHDINVEKFNLSAGVGEVNIYDAKISKDAEIKAGVGEVNFKDSTVTNMDIKSGVGSFSFSGTALGKTSVKGGIGEVDLKINGSEKDYDFDVSAGLGEVIINGKKSKTFLADRQKSGSIAQNSITVKGGIGSISIRFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LP6</accession>
    <name>Q73LP6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1816"/>
    <dbReference type="EnsemblBacteria" id="AAS12331">
        <property type="protein sequence ID" value="AAS12331"/>
        <property type="gene ID" value="TDE_1816"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1816"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1726"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_574697_0_0_12"/>
    <dbReference type="OMA" id="LFISYSW"/>
    <dbReference type="OrthoDB" id="1093343at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SEFIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08357">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51534">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEFIR" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="398" mass="46951" checksum="0BBBF4F2E5936731" modified="2004-07-05" version="1">MKVFISYAWTNNEYTSKILLLAERLMSDGVETIIDKWDLSAGQDKYAFMEQMIQDSSIDHVLIMLNREYKQKSDERKGGVGTEAQIISSDLYNKVDQTKFIPIVIEKDDSGRPYLPIYLNNRIYIDLSENENCEYRYEELLRLIYKRPQFQKPKLGTAPLWIFEDKENISNINIKERELITSLEKNHKSRIIKVRDYIEIIQSELINAEINEKYHGQHDFGKVALDSFTAMTPVKNSLLNVLKNIAIYDESIETFDEFFQFFRNIEKFYRPNTNKDNSSWTLGQYDNYALFFYELIISSMAILLKFNRYNLANKFLSNVLIKDNATNWMYGGLEKNIETIYDKFESLHIIPEYFQSITGKSFLHPVVEILKNRVFPSLFFSDIIEADLVLHYYRAFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LP9</accession>
    <name>Q73LP9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972417.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002689013.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1813"/>
    <dbReference type="EnsemblBacteria" id="AAS12328">
        <property type="protein sequence ID" value="AAS12328"/>
        <property type="gene ID" value="TDE_1813"/>
    </dbReference>
    <dbReference type="GeneID" id="2739243"/>
    <dbReference type="KEGG" id="tde:TDE_1813"/>
    <dbReference type="eggNOG" id="ENOG5033020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1989870_0_0_12"/>
    <dbReference type="OrthoDB" id="1733128at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="128" mass="15539" checksum="2BCBEDFACAE0F0BF" modified="2004-07-05" version="1">MVQYNMDKENCLIYEGVFFRIEWFYDKAGYSQAFEYFRKASPSQKRKFLMLVKKIGDFGKIFDKTKFRYEGDEIYAFKPQPDRYLCFFKKGQKIIVTNGFCKRRNKLPLAEKTIALENKKIYEHLYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LQ5</accession>
    <name>Q73LQ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972411.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010699606.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1807"/>
    <dbReference type="EnsemblBacteria" id="AAS12322">
        <property type="protein sequence ID" value="AAS12322"/>
        <property type="gene ID" value="TDE_1807"/>
    </dbReference>
    <dbReference type="GeneID" id="2739237"/>
    <dbReference type="KEGG" id="tde:TDE_1807"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1719"/>
    <dbReference type="eggNOG" id="COG2929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149290_1_1_12"/>
    <dbReference type="OMA" id="EAEMVFF"/>
    <dbReference type="OrthoDB" id="2065431at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038573">
        <property type="entry name" value="BrnT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007460">
        <property type="entry name" value="BrnT_toxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04365">
        <property type="entry name" value="BrnT_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="110" mass="13124" checksum="FA24A98BC5D1F73D" modified="2004-07-05" version="1">MYIILMGKTIISKDNRFEWDEEKNIANIEKHGIAFEEILEVFDDPAFLTGYDFEHSAKEDRYYGIGNLNGILIVLVFFTEKKNRIRLISARQAEKELREEYYDYFKKINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LT7</accession>
    <name>Q73LT7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972379.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1775"/>
    <dbReference type="EnsemblBacteria" id="AAS12290">
        <property type="protein sequence ID" value="AAS12290"/>
        <property type="gene ID" value="TDE_1775"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1775"/>
    <dbReference type="HOGENOM" id="CLU_218109_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="35" mass="4328" checksum="D600F8B6DE4C949B" modified="2004-07-05" version="1">MFETSRNDENVIKMTACTKNKFLFYDLSNFLEKYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LU0</accession>
    <name>Q73LU0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972376.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679522.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12287">
        <property type="protein sequence ID" value="AAS12287"/>
        <property type="gene ID" value="TDE_1772"/>
    </dbReference>
    <dbReference type="GeneID" id="2741216"/>
    <dbReference type="KEGG" id="tde:TDE_1772"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1690"/>
    <dbReference type="eggNOG" id="ENOG502ZUQ3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2107929_0_0_12"/>
    <dbReference type="OrthoDB" id="2136105at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="124" mass="14645" checksum="793EBAEC94A645C1" modified="2004-07-05" version="1">MKKSIILLSIFIFSLLVLYAKRTQPPEIPSIIHNGYEYIANYSDGIFKGTGQMIIKSIKDSKIKKTISIYSIWYNPFLEKDVQWIFIKETELIDNDTIRIYNENDEIFDLELINYKVKKIKKTT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-10-13" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LW4</accession>
    <name>OBG_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Obg</fullName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">obg</name>
        <name type="ordered locus">TDE_1748</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972352.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679468.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73LW4"/>
    <dbReference type="SMR" id="Q73LW4"/>
    <dbReference type="STRING" id="243275.TDE_1748"/>
    <dbReference type="EnsemblBacteria" id="AAS12263">
        <property type="protein sequence ID" value="AAS12263"/>
        <property type="gene ID" value="TDE_1748"/>
    </dbReference>
    <dbReference type="GeneID" id="2740593"/>
    <dbReference type="KEGG" id="tde:TDE_1748"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1671"/>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_0_12"/>
    <dbReference type="OMA" id="VVFDWEP"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000386365" description="GTPase Obg">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Obg" evidence="2">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="1">
        <location>
            <begin position="162"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="193"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="215"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="309"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="382" mass="42209" checksum="600CC2BB110C7520" modified="2004-07-05" version="1">MVKFADESKIRVSSGKGGNGCIAFRREKYVPMGGPSGGDGGRGGDLIFEIRRNMRTLVHLRHKRVYKAKNGGGGEGSQRFGKKGDDCIIPLPPGCVIKDPETGKTILDFGDAEEGRFVFLKGGNGGWGNCHFKTSTNQAPKTALPGQEGETREIIVELNIIADIGLVGFPNAGKSSLLDYFTNARPKIAPYPFTTKIPNLGVLRVDEERDVIIADIPGILEGASEGIGLGIRFLKHIARSAGLAFLIDLSDDNYLRAYDILCKELESYSKELAQKKRIIIATKLDLPDTKERFTELKNAIPDQEILGISLYNEWGLEEVKKAFIRLADEMQKTKPQKESLDPYGQNKNFMTAELDDVSYEEKNDDEHFGATVSLSRKRKPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LX8</accession>
    <name>Q73LX8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exodeoxyribonuclease III</fullName>
            <ecNumber evidence="4">3.1.11.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">xth</name>
        <name evidence="4" type="ordered locus">TDE_1734</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.2" evidence="4"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972338.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679455.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1734"/>
    <dbReference type="EnsemblBacteria" id="AAS12249">
        <property type="protein sequence ID" value="AAS12249"/>
        <property type="gene ID" value="TDE_1734"/>
    </dbReference>
    <dbReference type="GeneID" id="2739192"/>
    <dbReference type="KEGG" id="tde:TDE_1734"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1658"/>
    <dbReference type="eggNOG" id="COG0708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027539_1_3_12"/>
    <dbReference type="OMA" id="WWSYRGR"/>
    <dbReference type="OrthoDB" id="1893707at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008853">
        <property type="term" value="F:exodeoxyribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00727">
        <property type="entry name" value="AP_NUCLEASE_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="256" mass="29160" checksum="17453F9A1520D999" modified="2004-07-05" version="1">MNSIISWNVNGIRAVEKKGFLDWLNTENPDVLCVQETKAAKAQLSKELTEPDLPNGKYFAYWASAKKAGYSGTAIFTKKEPLQVRTMGLKEFDDEGRVLVADFDKVSIISAYFPNSQDGGARLDYKLDFCAAILEFCDSVQEEGNNVILCGDFNIAHKPIDLANPKSNEKNPGYLPEERAWMDEFTSSGYTDTFRHFCKEPAKYTWWSYRFRAREKNIGWRLDYHCVNDSFLAKIKESIILDGVMGSDHCPVKLIY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M83</accession>
    <name>GCSH_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gcvH</name>
        <name type="ordered locus">TDE_1626</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="1">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972232.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669223.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M83"/>
    <dbReference type="SMR" id="Q73M83"/>
    <dbReference type="STRING" id="243275.TDE_1626"/>
    <dbReference type="EnsemblBacteria" id="AAS12143">
        <property type="protein sequence ID" value="AAS12143"/>
        <property type="gene ID" value="TDE_1626"/>
    </dbReference>
    <dbReference type="GeneID" id="2739735"/>
    <dbReference type="KEGG" id="tde:TDE_1626"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1554"/>
    <dbReference type="eggNOG" id="COG0509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_2_12"/>
    <dbReference type="OMA" id="YRDSHEW"/>
    <dbReference type="OrthoDB" id="1773485at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0450">Lipoyl</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000022208" description="Glycine cleavage system H protein">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="2">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01066"/>
        </source>
    </evidence>
    <sequence length="122" mass="13585" checksum="1E74A8412472ECC7" modified="2004-07-05" version="1">MEIKEDVKYLESHEWFKKEGNIGIIGISDYAQSEMGDVVFIELPEVGDEVTADKACATVESVKAVFEIISPMTGKVVEINEELLDAPEKINEDAFGSWFFKVELKGESSKLMDAGKYKGLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MC5</accession>
    <name>Q73MC5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972190.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679259.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1584"/>
    <dbReference type="EnsemblBacteria" id="AAS12101">
        <property type="protein sequence ID" value="AAS12101"/>
        <property type="gene ID" value="TDE_1584"/>
    </dbReference>
    <dbReference type="GeneID" id="2739781"/>
    <dbReference type="KEGG" id="tde:TDE_1584"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1513"/>
    <dbReference type="eggNOG" id="COG2968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080344_1_2_12"/>
    <dbReference type="OMA" id="PWSISEF"/>
    <dbReference type="OrthoDB" id="1843994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007497">
        <property type="entry name" value="DUF541"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04402">
        <property type="entry name" value="SIMPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="249" mass="27737" checksum="2F73E5CB3B7A0078" modified="2004-07-05" version="1">MKNSSIKVIKLIGVLCICFVLFGACSPQASEKRFVSVTGRSSISKSPDQVSISFSVFSKDRDLSAAKKKNDAAILKLKELFEKYKIEQKNISIERVNINPRSRYRDNGDEYFDGYEVVQNIAVLITKIEDYEVFLTELLNTGVDRIYNVGFSVADMRKLMDEARVEAVKAAEEKALLLCKAATNSGKPLSLGKIISISEEPTGMFQRNYYNYAAQNMKEAADYEAAGGNFSPMGQIEVSAEISVVFELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MC9</accession>
    <name>Q73MC9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972186.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957002.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1580"/>
    <dbReference type="EnsemblBacteria" id="AAS12097">
        <property type="protein sequence ID" value="AAS12097"/>
        <property type="gene ID" value="TDE_1580"/>
    </dbReference>
    <dbReference type="GeneID" id="2739777"/>
    <dbReference type="KEGG" id="tde:TDE_1580"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1509"/>
    <dbReference type="eggNOG" id="COG2982">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021738_0_0_12"/>
    <dbReference type="OMA" id="INANMEI"/>
    <dbReference type="OrthoDB" id="236406at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019934">
        <property type="entry name" value="CHP03545"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03545">
        <property type="entry name" value="TIGR03545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="642"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="745" mass="84195" checksum="D7B6295EA85309FD" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MD3</accession>
    <name>MIAB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="1">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaB</name>
        <name type="ordered locus">TDE_1576</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972182.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679246.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MD3"/>
    <dbReference type="SMR" id="Q73MD3"/>
    <dbReference type="STRING" id="243275.TDE_1576"/>
    <dbReference type="EnsemblBacteria" id="AAS12093">
        <property type="protein sequence ID" value="AAS12093"/>
        <property type="gene ID" value="TDE_1576"/>
    </dbReference>
    <dbReference type="GeneID" id="2739773"/>
    <dbReference type="KEGG" id="tde:TDE_1576"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1505"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_2_0_12"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000374621" description="tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="148"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="387"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="451" mass="51918" checksum="43C825A8DD59BED5" modified="2004-07-05" version="1">MTYFFETYGCQMNQAESSSMEQILLEKGWTNSSDAEHCDLLIINTCSVRITAENRVLGRLGHFSGLKKKRKFFVLLIGCMAERLYTEIQKEFPLIDYVVGMFERNLLPQIFDEIKARLKNDNYMAEFTHDNIEEKPVSGYYFAPLSHSPKSFQSYVPIMNGCNNFCTYCIVPYVRGREVSRPVNEILQEITELSSRGVREITLLGQNVNSYKGEDGEGRLIDFPKLLTLIAREADKTDMIRWIRFMSSHPKDMSDALIDTIAAEKRLCKLVHLPVQHGSDTILKRMNRVYTIEHYKNRIKRLKETIPDIALSTDILMGFPGETEDDVKATLDLMQEIEFDSAFMYHYNPREGTKAFNYPDRIPEEVKIERLGRVIDLQLKITAKKMKAKLGKKVDILVESHSRNERSELFGHTEQGEMTVIQGNPPESLIGNFAHAELKELKGKTFRANLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MG5</accession>
    <name>Q73MG5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="8" type="ordered locus">TDE_1543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972149.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671179.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1543"/>
    <dbReference type="EnsemblBacteria" id="AAS12060">
        <property type="protein sequence ID" value="AAS12060"/>
        <property type="gene ID" value="TDE_1543"/>
    </dbReference>
    <dbReference type="GeneID" id="2740905"/>
    <dbReference type="KEGG" id="tde:TDE_1543"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1479"/>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025574_2_2_12"/>
    <dbReference type="OMA" id="IAMPGKA"/>
    <dbReference type="OrthoDB" id="708179at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="340" mass="38316" checksum="0034EF9E9A758405" modified="2004-07-05" version="1">MKKKSKIVIIILCIAGLLAGTIFFVLSLNNPPLEFSEPLVTFKIPRGTAAKTVIGELKAKNLIRSELYAYAYLRLKKLNLKAGTYQIRPEMTTHDILHKLTQGSQALKKLTIPEGLTLKKTAQVFETVGLIKAEDFIAITSDSDFLEKNEIKAKTAEGFLYPDTYFFGEEDTPEMMVKMIIKTFFEKTSSIPNFPKDFNEIYKKVILASIIEREYQLPEEAPIISSVFTNRLKINMGLQSCATVEYIITEIKNKKHPTRLFYEDLEIQSPYNTYIHEGLPPGPISNPGFTALNAACNPANTDYFYFRLIDPDTGKHVFTKTITEHNKAGEGLLLKKAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MP7</accession>
    <name>Q73MP7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Septum formation initiator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972067.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671296.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1461"/>
    <dbReference type="EnsemblBacteria" id="AAS11978">
        <property type="protein sequence ID" value="AAS11978"/>
        <property type="gene ID" value="TDE_1461"/>
    </dbReference>
    <dbReference type="GeneID" id="2741576"/>
    <dbReference type="KEGG" id="tde:TDE_1461"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1402"/>
    <dbReference type="eggNOG" id="COG2919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146778_0_0_12"/>
    <dbReference type="OMA" id="ELMVINH"/>
    <dbReference type="OrthoDB" id="1677401at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="149" mass="16949" checksum="F0244814DFFD45BF" modified="2004-07-05" version="1">MKIYFKVLIPIFITVFAYTVLTVFLGPKGIYAQHFIEAQRDTLVNHVRSLRQTGDDLDSLIRNLTYDPETIAIYAHELGYIYDNEGIIKLVNFNSGFGKGLNPGTILKIETPYFLSDYICKTIAASLGIIVIIFQMLAVRKDGYFKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MU5</accession>
    <name>Q73MU5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium/hydrogen exchanger family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972018.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679009.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1412"/>
    <dbReference type="EnsemblBacteria" id="AAS11929">
        <property type="protein sequence ID" value="AAS11929"/>
        <property type="gene ID" value="TDE_1412"/>
    </dbReference>
    <dbReference type="GeneID" id="2739689"/>
    <dbReference type="KEGG" id="tde:TDE_1412"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1354"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031031_2_1_12"/>
    <dbReference type="OMA" id="FRHNPMV"/>
    <dbReference type="OrthoDB" id="626953at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="6">
        <location>
            <begin position="25"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="447"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="574" mass="61333" checksum="514FB559EE3245AC" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MW0</accession>
    <name>Q73MW0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972002.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1396"/>
    <dbReference type="EnsemblBacteria" id="AAS11913">
        <property type="protein sequence ID" value="AAS11913"/>
        <property type="gene ID" value="TDE_1396"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1396"/>
    <dbReference type="eggNOG" id="ENOG5031DG1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1916151_0_0_12"/>
    <dbReference type="OrthoDB" id="2128425at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="128" mass="15151" checksum="038F42BA99DA19F9" modified="2004-07-05" version="1">MAYMLYILALAIEILRVLLFTYIEKAQPWPLSIVDWIAFVFLCMPAVFFFLLLHQEKDFHQLLRIIAGIKFLSIIAAWFFLIKTARFVSLTDWTADAFILQTRVTRLFLYIDTLILILCLKRERSLCK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MZ2</accession>
    <name>SYV_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Valyl-tRNA synthetase</fullName>
            <shortName evidence="1">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">valS</name>
        <name type="ordered locus">TDE_1364</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971970.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678931.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MZ2"/>
    <dbReference type="SMR" id="Q73MZ2"/>
    <dbReference type="STRING" id="243275.TDE_1364"/>
    <dbReference type="EnsemblBacteria" id="AAS11881">
        <property type="protein sequence ID" value="AAS11881"/>
        <property type="gene ID" value="TDE_1364"/>
    </dbReference>
    <dbReference type="GeneID" id="2739465"/>
    <dbReference type="KEGG" id="tde:TDE_1364"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1310"/>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_12"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000224591" description="Valine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="843"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="542"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <sequence length="909" mass="103905" checksum="5C6C961DB1887F98" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N35</accession>
    <name>Q73N35_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971927.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678865.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1321"/>
    <dbReference type="EnsemblBacteria" id="AAS11838">
        <property type="protein sequence ID" value="AAS11838"/>
        <property type="gene ID" value="TDE_1321"/>
    </dbReference>
    <dbReference type="GeneID" id="2739579"/>
    <dbReference type="KEGG" id="tde:TDE_1321"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1270"/>
    <dbReference type="eggNOG" id="COG1739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083552_2_1_12"/>
    <dbReference type="OMA" id="VTVDHQR"/>
    <dbReference type="OrthoDB" id="1777855at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015796">
        <property type="entry name" value="Impact_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015269">
        <property type="entry name" value="UPF0029_Impact_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09186">
        <property type="entry name" value="DUF1949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00257">
        <property type="entry name" value="IMPACT_YIGZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="15"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1949" evidence="3">
        <location>
            <begin position="137"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="202" mass="22285" checksum="1D74078FF258086D" modified="2004-07-05" version="1">MKVLMRYASSELNVKSSRFLAEIFPINSAAEARELLKSQKGKYEDARHVVHAFIAGENGEVLGCSDDGEPSGTAGRPALAVLKGSGITNIMLTITRWFGGTLLGTGGLVKAYSDSAKLVLQEASTEELIKKEPFQFECSYSEWENLKRSLDEFSVEMLQADYSEKVRVNGQIPLEKKAPFEAFIENASKGGISLVFPMYDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N55</accession>
    <name>Q73N55_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">recN</name>
        <name evidence="8" type="ordered locus">TDE_1301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971907.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678799.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1301"/>
    <dbReference type="EnsemblBacteria" id="AAS11818">
        <property type="protein sequence ID" value="AAS11818"/>
        <property type="gene ID" value="TDE_1301"/>
    </dbReference>
    <dbReference type="GeneID" id="2741055"/>
    <dbReference type="KEGG" id="tde:TDE_1301"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1251"/>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018297_3_1_12"/>
    <dbReference type="OMA" id="QVICVTH"/>
    <dbReference type="OrthoDB" id="1074831at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="168"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="561" mass="62598" checksum="0865B9FAB0A9DFA7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NA3</accession>
    <name>Q73NA3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971859.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668528.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1252"/>
    <dbReference type="EnsemblBacteria" id="AAS11770">
        <property type="protein sequence ID" value="AAS11770"/>
        <property type="gene ID" value="TDE_1252"/>
    </dbReference>
    <dbReference type="GeneID" id="2741428"/>
    <dbReference type="KEGG" id="tde:TDE_1252"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1204"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1433903_0_0_12"/>
    <dbReference type="OMA" id="YNQGLYR"/>
    <dbReference type="OrthoDB" id="1563419at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="204" mass="23956" checksum="5E3C6E96CFAFF22A" modified="2004-07-05" version="1">MVKINKIICISILIFLISSCSKVDRARLNFLSGYIAWKQNDWNKAASNFFKSIDLSEEVEDVKIKDYSDFAIGSIYLMQNEDASALSRFEKINENTDKNLNSYIYYQKGIIAFKNHEYEKAVRLFKKSLELKPDSVDAKINFELSMRYQKKQKEKLPNSKSAAVIENKEADLLEKTILNLIRQKEKEQWQKKEQENKQPQAFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NB5</accession>
    <name>Q73NB5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971847.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1240"/>
    <dbReference type="EnsemblBacteria" id="AAS11758">
        <property type="protein sequence ID" value="AAS11758"/>
        <property type="gene ID" value="TDE_1240"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1240"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1192"/>
    <dbReference type="eggNOG" id="COG1702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051654_0_1_12"/>
    <dbReference type="OMA" id="PAQMKMV"/>
    <dbReference type="OrthoDB" id="445854at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="95"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="300" mass="33228" checksum="C7EDE7D52C8B3D26" modified="2004-07-05" version="1">MLSALCGTNDRNLDFLEQYLGVPVVCRGNEVSVLSADDEICKKFQHVVDKAVNSSEIKSENSSEYIESLISTINVSDEQDLSSGCIHIPRGTRSVYPKNPHQLEFISSIRNNDISFGLGAAGTGKTYLAVACALQMLMSRQMRKIVFTRPVVEAGESLGFLPGDLVQKITPYLRPLYDSIELLMPFELIRQMEESNMVEVAPLAYMRGRTLHNAVVILDEAQNTTKEQMKMFLTRMGEGSKLIITGDPSQSDISSSKNSGLVHAANLLSKIRGIGIVRFSPEDVVRHSLVQKIIKAYDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NF3</accession>
    <name>Q73NF3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">murF</name>
        <name evidence="11" type="ordered locus">TDE_1200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971807.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678687.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1200"/>
    <dbReference type="EnsemblBacteria" id="AAS11718">
        <property type="protein sequence ID" value="AAS11718"/>
        <property type="gene ID" value="TDE_1200"/>
    </dbReference>
    <dbReference type="GeneID" id="2741161"/>
    <dbReference type="KEGG" id="tde:TDE_1200"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1155"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031507_1_2_12"/>
    <dbReference type="OMA" id="VEMGANH"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="39"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="133"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="335"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="135"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="476" mass="52836" checksum="DA65C2A423E18852" modified="2004-07-05" version="1">MVRENLSNNLDYSLMNLDELLTSTGAWLVYESNSSKAFSSVVMDSRNVKNNSLFIPLRGENQDGHVYIEPALKNGAKFFVVDFDYLDENETALLSLCKNYDASCVAVKNNLKALQDAARYYLSKFPNLYKIGITGSSGKTTTKEILASIYSKKYNTVSTKGNLNSETGLPLSVFEVRPEHEAGIFELGMNRKGEIAEIASVLLPNAAIITNIGTAHIGILGTKQAIAEEKKEIFSFFKDDSLGFIPECEFTDFLKDIPHGSVFTVSDNDSSLVQKVEDAGVLGSKIFYKGEEILFPLPGVYNVKNALLCIALAEKKGFSAKEIKSGLEAVRPLFGRSQVLHGFVTYFLDCYNANPDSMKSAIEFCDSINTECAKHYVLASMLELGAESDYEHKKIIEDALKSNADNLYFFGDDICSAFEGMNVSSSKKIYKFKTNQFDALKEQLKENLSKDDFVLLKGSRSMELERLESVLKEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NG8</accession>
    <name>Q73NG8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971792.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1184"/>
    <dbReference type="EnsemblBacteria" id="AAS11703">
        <property type="protein sequence ID" value="AAS11703"/>
        <property type="gene ID" value="TDE_1184"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1184"/>
    <dbReference type="HOGENOM" id="CLU_3367949_0_0_12"/>
    <dbReference type="OrthoDB" id="847145at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="35" mass="4071" checksum="81EDF6609C59B199" modified="2004-07-05" version="1">MDDMKNPGIRGMHRFLAKDGDGIMKMSIIRMDFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NI4</accession>
    <name>Q73NI4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971776.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956914.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1168"/>
    <dbReference type="EnsemblBacteria" id="AAS11657">
        <property type="protein sequence ID" value="AAS11657"/>
        <property type="gene ID" value="TDE_1168"/>
    </dbReference>
    <dbReference type="GeneID" id="2740065"/>
    <dbReference type="KEGG" id="tde:TDE_1168"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1126"/>
    <dbReference type="HOGENOM" id="CLU_1517269_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="177" mass="20689" checksum="CE6AD6501EB7C422" modified="2004-07-05" version="1">MKFDVDLYKVKALEHCEDPKEEHILCGFYYEVAGVDFLDVGNEGFTERLECPINTYPIRPYTVCRNTGVKINGEYLYEFDLVIFGNDDRMGIIVWNEFVMSYVINPSNNYSSFLRLKGPDSHIKKIIGNYMLSDADSKKFQKYSDDLDAKYRGPEPTVECRSQQHINREIKRFLPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NL0</accession>
    <name>Q73NL0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phage minor structural protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971750.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956889.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1142"/>
    <dbReference type="EnsemblBacteria" id="AAS11631">
        <property type="protein sequence ID" value="AAS11631"/>
        <property type="gene ID" value="TDE_1142"/>
    </dbReference>
    <dbReference type="GeneID" id="2740001"/>
    <dbReference type="KEGG" id="tde:TDE_1142"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1101"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_227396_0_0_12"/>
    <dbReference type="OrthoDB" id="2016574at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040824">
        <property type="entry name" value="LPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041131">
        <property type="entry name" value="MuF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18798">
        <property type="entry name" value="LPD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18819">
        <property type="entry name" value="MuF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LPD3" evidence="3">
        <location>
            <begin position="865"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="MuF_C" evidence="4">
        <location>
            <begin position="1198"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="996"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="832"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1045"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1729"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="2689" mass="304635" checksum="774C76732A815EA3" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NL6</accession>
    <name>Q73NL6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M23/M37 peptidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971744.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956883.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1136"/>
    <dbReference type="EnsemblBacteria" id="AAS11625">
        <property type="protein sequence ID" value="AAS11625"/>
        <property type="gene ID" value="TDE_1136"/>
    </dbReference>
    <dbReference type="GeneID" id="2739995"/>
    <dbReference type="KEGG" id="tde:TDE_1136"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1095"/>
    <dbReference type="HOGENOM" id="CLU_1585734_0_0_12"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="8"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="168" mass="18653" checksum="B701D8335DFA58B2" modified="2004-07-05" version="1">MRIEKWGVFAIKEGRIIKINRDAKASVYGNYVIIKDRQGIISRYAHLKSIAVNVGQTVPAGGFLGIMGDTGRGIPGPNKHLHVSVYPATTKDPYMGKDATIDPKSYILDRGIYPCNSKPSTDFHQMIGNPPYPHEGLDFSGLDKNIITGWEAGTFEIKNIFEEFKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NP1</accession>
    <name>Q73NP1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971719.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670666.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1111"/>
    <dbReference type="TCDB" id="2.A.23.3.4">
        <property type="family name" value="the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11600">
        <property type="protein sequence ID" value="AAS11600"/>
        <property type="gene ID" value="TDE_1111"/>
    </dbReference>
    <dbReference type="GeneID" id="2739527"/>
    <dbReference type="KEGG" id="tde:TDE_1111"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1071"/>
    <dbReference type="eggNOG" id="COG1301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056006_0_0_12"/>
    <dbReference type="OMA" id="EAYLIFR"/>
    <dbReference type="OrthoDB" id="781228at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001991">
        <property type="entry name" value="Na-dicarboxylate_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42865">
        <property type="entry name" value="PTHR42865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00375">
        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="SSF118215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="409" mass="44766" checksum="52C78E244698AD83" modified="2004-07-05" version="1">MKIWIKYLIGSVLGIIIAAISSSDSAFFNAAVDFAANIAIQFGRYSLYPVLFFGFTVSISKLRESRSLLKLSIYIAVFIILSSLLAALLGLISISISSPPRIPIFVEETSSVENLGVMESFLRLFPSSAFEAFMDGLYILPLCIFAGFAGAACAVDKNISKPVFTLFDSLSRVSYAVMAFFVDMFSIGLIAVSVNWFIKFQAMLSTKFFTGLVVLLLVDFFIIALIIYPIILKIMCKDINPYKVLYASIAPVCAAFFSGDTNLTLPILLRHSNESLGVRRRISSVSLPVFSVFGRAGSAMVVTISFIVILNSYSSLGISFEDRFWLVGISTLFSFFLGRFPITGTYVSLVAVCAIYGRGFESGFLILRPAAFFIGSVAAAIDALTAMVGTYIIGHLSKMTNTRTLRFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NP3</accession>
    <name>Q73NP3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Decarboxylase, pyridoxal-dependent family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971717.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670664.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1109"/>
    <dbReference type="EnsemblBacteria" id="AAS11598">
        <property type="protein sequence ID" value="AAS11598"/>
        <property type="gene ID" value="TDE_1109"/>
    </dbReference>
    <dbReference type="GeneID" id="2740239"/>
    <dbReference type="KEGG" id="tde:TDE_1109"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1069"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_1_3_12"/>
    <dbReference type="OMA" id="SFFVCDL"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="PTHR11482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="3">
        <location>
            <begin position="32"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="2">
        <location>
            <begin position="269"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="389" mass="44390" checksum="D8C3486351E951F2" modified="2004-07-05" version="1">MERKDYISDSEWKHFMSFSENLETPCVVINLKTIKKNYQKLRENFPYADIFYAIKANPHEEIISMLNEMGSCFDIASRYELDKVLKLGVSPERLSYGNTIKKAKDIAYFYEKGVRMFATDSKDDLKNIAQFAPGSRVYVRILVENTTSADWPLSRKFGCHPDMAYDLCIQARDSGLIPYGISFHVGSQQRDIGQWNDAIAKTKYLMDSLEEEEEIKLEMVNMGGGFPASYVTPANDLSEYASEISRYLEDDFGEERPRIILEPGRSLVGDSGILVTEVVMISRKNNTALFRWVYLDTGLFNGLIETLNESLKYPIITDKDEGCKKWGEVVLAGPTCDSMDIMYEDYKYSLPTNLKPGDRVYFLTTGAYTSSYASVEFNGFPPIKTYIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NP9</accession>
    <name>Q73NP9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971711.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670653.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11592">
        <property type="protein sequence ID" value="AAS11592"/>
        <property type="gene ID" value="TDE_1103"/>
    </dbReference>
    <dbReference type="GeneID" id="2740233"/>
    <dbReference type="KEGG" id="tde:TDE_1103"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1062"/>
    <dbReference type="eggNOG" id="ENOG5031CUY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2653416_0_0_12"/>
    <dbReference type="OrthoDB" id="2006715at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="76" mass="8186" checksum="CAE5523C748603D4" modified="2004-07-05" version="1">MKCKYCGKDVRPVGPNLESDDNGYNCPASVSKKHAIIPDGSHCIHCGRETKILGDRVVTSYGIRCSASPSGRHAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NR0</accession>
    <name>Q73NR0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971700.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682402.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1092"/>
    <dbReference type="EnsemblBacteria" id="AAS11581">
        <property type="protein sequence ID" value="AAS11581"/>
        <property type="gene ID" value="TDE_1092"/>
    </dbReference>
    <dbReference type="GeneID" id="2740222"/>
    <dbReference type="KEGG" id="tde:TDE_1092"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1051"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006550_0_0_12"/>
    <dbReference type="OrthoDB" id="98549at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="587"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="935"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1119" mass="127263" checksum="16A77F99C8EE60EA" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NW1</accession>
    <name>PNP_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polynucleotide phosphorylase</fullName>
            <shortName evidence="1">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pnp</name>
        <name type="ordered locus">TDE_1041</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971649.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682350.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NW1"/>
    <dbReference type="SMR" id="Q73NW1"/>
    <dbReference type="STRING" id="243275.TDE_1041"/>
    <dbReference type="EnsemblBacteria" id="AAS11530">
        <property type="protein sequence ID" value="AAS11530"/>
        <property type="gene ID" value="TDE_1041"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:mRNA catabolic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KH_dom"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
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        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
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    </dbReference>
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        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
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        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword id="KW-0963">Cytoplasm</keyword>
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    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000329920" description="Polyribonucleotide nucleotidyltransferase">
        <location>
            <begin position="1"/>
            <end position="698"/>
        </location>
    </feature>
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        <location>
            <begin position="552"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="622"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <sequence length="698" mass="76770" checksum="D95EBC96EAD24C23" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P38</accession>
    <name>Q73P38_TREDE</name>
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        <submittedName>
            <fullName evidence="3">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS11452">
        <property type="protein sequence ID" value="AAS11452"/>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.925"/>
    <dbReference type="eggNOG" id="COG2214">
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    </dbReference>
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    <dbReference type="OMA" id="EANMIIR"/>
    <dbReference type="OrthoDB" id="1505107at2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="137" mass="15752" checksum="D2AA37F990E7D4EC" modified="2004-07-05" version="1">MSKNYYNDMGNILRDALTSDDDPFEAAAQRSTGRYRTIGGRMERRPPPKVNKEALRIPVPPELIEDFAVLNVLSGVPLDECKRSWKRLIKKHHPDVQSSPAKQAEANMIIRRINNSYRKIETWFKTGKILSEKDLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P64</accession>
    <name>Q73P64_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
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            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0935"/>
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        <property type="protein sequence ID" value="AAS11426"/>
        <property type="gene ID" value="TDE_0935"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0935"/>
    <dbReference type="HOGENOM" id="CLU_3405973_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3512" checksum="30701E7D08752384" modified="2004-07-05" version="1">MTQPEIKHKKECQKGTNTAFCVLLIFQEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P78</accession>
    <name>Q73P78_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0921</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971531.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682220.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS11412">
        <property type="protein sequence ID" value="AAS11412"/>
        <property type="gene ID" value="TDE_0921"/>
    </dbReference>
    <dbReference type="GeneID" id="2740386"/>
    <dbReference type="KEGG" id="tde:TDE_0921"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.889"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OMA" id="VMVPQDG"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
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        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
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        <location>
            <begin position="26"/>
            <end position="313"/>
        </location>
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    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="343"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="376"/>
            <end position="383"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="579" mass="65179" checksum="2F63FC2718EE5B09" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PB0</accession>
    <name>Q73PB0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_002670231.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="protein sequence ID" value="AAS11380"/>
        <property type="gene ID" value="TDE_0889"/>
    </dbReference>
    <dbReference type="GeneID" id="2739763"/>
    <dbReference type="KEGG" id="tde:TDE_0889"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.859"/>
    <dbReference type="eggNOG" id="ENOG5031CX0">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000008212">
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    </dbReference>
    <dbReference type="InterPro" id="IPR008420">
        <property type="entry name" value="Borrelia_P13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05628">
        <property type="entry name" value="Borrelia_P13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="214" mass="23864" checksum="A7A4B9341880F1D8" modified="2004-07-05" version="1">MKKMFMVTVLLLIGFYLYSEETVKQTKEDDESFSYYLTVNQLISKNLFKNKDLISEYSQKLNNEQILLIQKKYQKDLAVPLLLNGFVGFGSGNFACGDMLGGGIHAAIDGLSVLSMLTMQFINLVDLFSTTSSDPLASIANIDRRMKIFSYVAYSAGSIMLVNRIASLITASLYVKRYNQTLNDVLIKKIPKVSFTPVPVISPEGVGLALNIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PD3</accession>
    <name>Q73PD3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971476.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682138.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0866"/>
    <dbReference type="EnsemblBacteria" id="AAS11357">
        <property type="protein sequence ID" value="AAS11357"/>
        <property type="gene ID" value="TDE_0866"/>
    </dbReference>
    <dbReference type="GeneID" id="2741377"/>
    <dbReference type="KEGG" id="tde:TDE_0866"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.836"/>
    <dbReference type="eggNOG" id="ENOG5032GSF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894123_0_0_12"/>
    <dbReference type="OrthoDB" id="2113102at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="311" mass="35938" checksum="E0BA72E1A5166093" modified="2004-07-05" version="1">MKNWLLVPLVFILNFVLAVLAFSISVGIWQSLMYGDVSGIFFSSFLHCLYLILPIACIISIFAVYVFMMRHSEKRGLSFLALIISFALFFALIIPLVYSQGEKINQAFNSKEKVSIDDKHLETFIERPVFVQAAGSIVRPFVHDIYEQYKASYTSYLIFSGSIFLLIFSLWVFTTITEWKIVNFTLLPLLLILILYAYSYIRTDDFILSIEDVLPFAIPKFWIRPVLFCLAALLIYIYTMMLLLVRRAKKMPKKQKIKKQKINVPKVKKPKVPKIKMPKPVKPKKGEKIKEEFETFIPDNLGDFGEADIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PE9</accession>
    <name>Q73PE9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_0850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971460.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682111.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0850"/>
    <dbReference type="EnsemblBacteria" id="AAS11341">
        <property type="protein sequence ID" value="AAS11341"/>
        <property type="gene ID" value="TDE_0850"/>
    </dbReference>
    <dbReference type="GeneID" id="2739627"/>
    <dbReference type="KEGG" id="tde:TDE_0850"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.819"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_12"/>
    <dbReference type="OMA" id="KTINEMA"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="334"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="435"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="721" mass="77901" checksum="3C4AE72DF21D38A6" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PH7</accession>
    <name>Q73PH7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971432.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0822"/>
    <dbReference type="EnsemblBacteria" id="AAS11313">
        <property type="protein sequence ID" value="AAS11313"/>
        <property type="gene ID" value="TDE_0822"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0822"/>
    <dbReference type="HOGENOM" id="CLU_3298094_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="40" mass="4613" checksum="1C6B91C2499A8343" modified="2004-07-05" version="1">MKSKYVLLDAVITVISGQTFTINQFSSVHEFDIQKILQNR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PK9</accession>
    <name>RS11_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsK</name>
        <name type="ordered locus">TDE_0790</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971400.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670039.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PK9"/>
    <dbReference type="SMR" id="Q73PK9"/>
    <dbReference type="STRING" id="243275.TDE_0790"/>
    <dbReference type="EnsemblBacteria" id="AAS11281">
        <property type="protein sequence ID" value="AAS11281"/>
        <property type="gene ID" value="TDE_0790"/>
    </dbReference>
    <dbReference type="GeneID" id="2740668"/>
    <dbReference type="KEGG" id="tde:TDE_0790"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.763"/>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_5_0_12"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="OrthoDB" id="1713391at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000123248" description="30S ribosomal protein S11">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <sequence length="126" mass="13614" checksum="1B6CE4EA3D482194" modified="2004-07-05" version="1">MATVKKRKEKKSIYEGNVYIQATFNNTIITITDLKGNVLSWASSGGLGFAGAKKSTPFAAQTVAETAVQKCQPYGLHEVHVFVKGPGVGRESAIRTLGTMGLKVRSISDVTPIPHNGCRPKKTRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PP3</accession>
    <name>Q73PP3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971365.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682015.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0754"/>
    <dbReference type="EnsemblBacteria" id="AAS11246">
        <property type="protein sequence ID" value="AAS11246"/>
        <property type="gene ID" value="TDE_0754"/>
    </dbReference>
    <dbReference type="GeneID" id="2739873"/>
    <dbReference type="KEGG" id="tde:TDE_0754"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.729"/>
    <dbReference type="HOGENOM" id="CLU_1377591_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004286026" evidence="1">
        <location>
            <begin position="20"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="201" mass="22993" checksum="B0CB5E3FE35A6CAA" modified="2004-07-05" version="1">MKKAISIIFIFLLSCAAFAQNYSKPGRNEVVLVFSVEIRPSVNREFFKEYLSIPSMPMSDLIINETGRPVSNDPGDSISLYCEGDDKLDKPTAVSDVEEIISIKVPVPRSSEIVLNFCTYNFFKGTAFRFFLPFAVKIKVQPDFKYYYLGHLEYKRKGGMEYEIVDVKKHDNYDVVVPIIKKRYGENAELVRAAMTSIDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PS1</accession>
    <name>Q73PS1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971337.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681964.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0725"/>
    <dbReference type="EnsemblBacteria" id="AAS11218">
        <property type="protein sequence ID" value="AAS11218"/>
        <property type="gene ID" value="TDE_0725"/>
    </dbReference>
    <dbReference type="GeneID" id="2740089"/>
    <dbReference type="KEGG" id="tde:TDE_0725"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.701"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_0_3_12"/>
    <dbReference type="OMA" id="PWPSFTQ"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="391" mass="43636" checksum="02615786F1B7E75F" modified="2004-07-05" version="1">MQDVQAKKTIPFFTPSFSEEEEKALMRVLRSGWLTTGKETLEFEKEFASFTGSKTALAVNSASSGLMLAMDACGIKSGTKILTSPYTFISTATSALHLGGDVVYADIEKDSYSIDPEKIETTLKKDKNVKAIVPIHIAGNVCNMKAINDLAKKYSVAVIEDAAHAFPSKTKEGYAGTLGTCGVFSFYATKTITTGEGGMICTNDEKIAERIKLMRSHGINRTIWDRYTDTKASWKYDVTAEGWKCNLPDILSAIGRVQLKKAKTFFEQRKKIAQKYNAAFAGNDSFILPPDGEGNAWHLYILRLNLEALKIGRDEFGQALQERGLGISMHFIPHFEMSYIKERYGLNSFDFPESNKKYLQSLSLPFYPSMSEDDSDYVIETVIKLAKLNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PS6</accession>
    <name>Q73PS6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bacteriocin ABC transporter, bacteriocin-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971332.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681956.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0720"/>
    <dbReference type="EnsemblBacteria" id="AAS11213">
        <property type="protein sequence ID" value="AAS11213"/>
        <property type="gene ID" value="TDE_0720"/>
    </dbReference>
    <dbReference type="GeneID" id="2740627"/>
    <dbReference type="KEGG" id="tde:TDE_0720"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.696"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023976_7_0_12"/>
    <dbReference type="OMA" id="QQYATES"/>
    <dbReference type="OrthoDB" id="1395473at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="380" mass="43655" checksum="E4DF921510B8A673" modified="2004-07-05" version="1">MKIKDLETIKNRILFFEYRFPVVYTCFIYIILFIFIITLLWICFAEMDQTVKASGILRLKTNTSIGKAAYSGTVKSKKFKSGSRIKKGDILLILETADIEEDKTNTENEIHRLNKEINNLLLYEKAVHSDKNNVPLEHAIAKARAEIYFAKKEKLRIFYEEAKEEYAHEKELPSSMKTKKSLSSLFDKFKIAELDYKTFSAQEIINIESEKNLLTQKLESAKKTLTRLNKEISESKIISPLNGTVEELIRINEGDYIFSGTEILRIIPDMIEELKAELIISDKDIAELKIGMEVNLKFTALPPSEYGVLKGVITNISNDSFNNQNTSSFFLVDADILSFSLKNNEQKEVKLKPGMSTEAHIIIKHKTIIKFILEKLDFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PV1</accession>
    <name>Q73PV1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971307.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681919.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0695"/>
    <dbReference type="EnsemblBacteria" id="AAS11188">
        <property type="protein sequence ID" value="AAS11188"/>
        <property type="gene ID" value="TDE_0695"/>
    </dbReference>
    <dbReference type="GeneID" id="2739817"/>
    <dbReference type="KEGG" id="tde:TDE_0695"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.674"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055441_0_0_12"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="351" mass="39606" checksum="B8698CF161B5373D" modified="2004-07-05" version="1">MKFFLREIKYYSIGMFYSLDGMFWTLLYPILMAGLFFTIFSAVGNSDTGKIEIGIEKDNPVYYPLKFTGMFDTKIIDEASANEMLRTKKIKAFIEADQSLRLSEDGLSQTITKTVLDQIKQIKALNIPMNSFEYGKNYVESKNEKMSLSIILFYSLLAMVSIYTMFGSIDIAVKIQGNISKIGARICTTPIKRFYSYLAGIIFYIIFNLTANLIYISFVLFVLNIPFITDFKITLLLLIYANFFGAALGLFIGSTSIGDIRSKNMICVFTSLFLAFLSGMMGPEVKISLEKAIPILGTINPIAIFTTNLYNINILGEYNAVPLFFIVYTIGIVILLSLSFINSRKVQYDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PV3</accession>
    <name>Q73PV3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="2">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiD</name>
        <name evidence="2" type="ordered locus">TDE_0693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.4.7" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971305.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681916.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0693"/>
    <dbReference type="EnsemblBacteria" id="AAS11186">
        <property type="protein sequence ID" value="AAS11186"/>
        <property type="gene ID" value="TDE_0693"/>
    </dbReference>
    <dbReference type="GeneID" id="2739815"/>
    <dbReference type="KEGG" id="tde:TDE_0693"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.672"/>
    <dbReference type="eggNOG" id="COG0351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_0_0_12"/>
    <dbReference type="OMA" id="KDEVGYA"/>
    <dbReference type="OrthoDB" id="461201at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="1">
        <location>
            <begin position="11"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="269" mass="28983" checksum="BAC6A1814483713D" modified="2004-07-05" version="1">MIKLATIAGSDASGGAGLEADLKTFQEYGVYGMAAVTVIATMNPDKEWGHEVFPLDEQAIRAQLETIFKGIGVNAAKTGMLATNYAVELSAEYLKKYNVENYVLDPVMVCKGGDLALNPELNNLIIKKLLPLAKLITPNLFEAGQIAKMPTPSTIEEIKEACKIIHGMGVPYVFIKGGPKLNGEQSAIDIFYDGEQFLKVEGGLTDTRWTHGAGCTTAAAIAAGLGIGLEPYEAVRRSKKFITLSLQNGFQLNKWVGPGNPAAWRKSFN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2015-10-14" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PV9</accession>
    <name>PURE_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="1 2">4.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1 3">AIR carboxylase</fullName>
            <shortName evidence="1 4">AIRC</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">purE</name>
        <name evidence="6" type="ordered locus">TDE_0687</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2011" name="Biochemistry" volume="50" first="4623" last="4637">
            <title>Treponema denticola PurE is a bacterial AIR carboxylase.</title>
            <authorList>
                <person name="Tranchimand S."/>
                <person name="Starks C.M."/>
                <person name="Mathews I.I."/>
                <person name="Hockings S.C."/>
                <person name="Kappock T.J."/>
            </authorList>
            <dbReference type="PubMed" id="21548610"/>
            <dbReference type="DOI" id="10.1021/bi102033a"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) IN COMPLEX WITH 5-AMINOIMIDAZOLE RIBONUCLEOTIDE</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>PATHWAY</scope>
        <scope>MASS SPECTROMETRY</scope>
        <scope>SUBFAMILY</scope>
        <scope>MUTAGENESIS OF HIS-40</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). Does not accept N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) as a substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">13 mM for CO(2) (at 10 degrees Celsius)</KM>
            <KM evidence="2">60 uM for AIR (at 10 degrees Celsius)</KM>
            <text evidence="2">kcat is 77 sec(-1).</text>
        </kinetics>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="mass spectrometry" mass="17195.0" error="3.0" method="Electrospray" evidence="2"/>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AIR carboxylase family. Class II subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="1 2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971299.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681904.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="PDB" id="3RG8">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.74 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H=1-159"/>
    </dbReference>
    <dbReference type="PDB" id="3RGG">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.82 A"/>
        <property type="chains" value="A/B/C/D=1-159"/>
    </dbReference>
    <dbReference type="PDB" id="5C5D">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.69 A"/>
        <property type="chains" value="A/B/C/D=1-159"/>
    </dbReference>
    <dbReference type="PDBsum" id="3RG8"/>
    <dbReference type="PDBsum" id="3RGG"/>
    <dbReference type="PDBsum" id="5C5D"/>
    <dbReference type="AlphaFoldDB" id="Q73PV9"/>
    <dbReference type="SMR" id="Q73PV9"/>
    <dbReference type="STRING" id="243275.TDE_0687"/>
    <dbReference type="EnsemblBacteria" id="AAS11180">
        <property type="protein sequence ID" value="AAS11180"/>
        <property type="gene ID" value="TDE_0687"/>
    </dbReference>
    <dbReference type="GeneID" id="2740246"/>
    <dbReference type="KEGG" id="tde:TDE_0687"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.667"/>
    <dbReference type="eggNOG" id="COG0041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094982_2_0_12"/>
    <dbReference type="OMA" id="TKPVIAC"/>
    <dbReference type="OrthoDB" id="1560434at2"/>
    <dbReference type="BRENDA" id="4.1.1.21">
        <property type="organism ID" value="6426"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q73PV9"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043727">
        <property type="term" value="F:5-amino-4-imidazole carboxylate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02045">
        <property type="entry name" value="PurE_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033626">
        <property type="entry name" value="PurE_classII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000434131" description="Phosphoribosylaminoimidazole carboxylase">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2 8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2 8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2 8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2 8">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2 8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2 8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="mutagenesis site" description="Lack of activity." evidence="2">
        <original>H</original>
        <variation>N</variation>
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="4"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="turn" evidence="9">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="60"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="strand" evidence="9">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="93"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="99"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="turn" evidence="9">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="helix" evidence="9">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="21548610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="21548610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="21548610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="7">
        <source>
            <dbReference type="PDB" id="3RG8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="8">
        <source>
            <dbReference type="PDB" id="3RGG"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="5C5D"/>
        </source>
    </evidence>
    <sequence length="159" mass="17196" checksum="F91B7B6D09DD8C87" modified="2004-07-05" version="1">MRPLVIILMGSSSDMGHAEKIASELKTFGIEYAIRIGSAHKTAEHVVSMLKEYEALDRPKLYITIAGRSNALSGFVDGFVKGATIACPPPSDSFAGADIYSSLRMPSGISPALVLEPKNAALLAARIFSLYDKEIADSVKSYMESNAQKIIEDDSKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PW8</accession>
    <name>Q73PW8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0033 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971290.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681889.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0677"/>
    <dbReference type="EnsemblBacteria" id="AAS11171">
        <property type="protein sequence ID" value="AAS11171"/>
        <property type="gene ID" value="TDE_0677"/>
    </dbReference>
    <dbReference type="GeneID" id="2739670"/>
    <dbReference type="KEGG" id="tde:TDE_0677"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.658"/>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097491_0_0_12"/>
    <dbReference type="OMA" id="CGTCLNF"/>
    <dbReference type="OrthoDB" id="1385159at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019870">
        <property type="entry name" value="Se_metab_YedF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03527">
        <property type="entry name" value="selenium_YedF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="197" mass="21408" checksum="9C4816F4AFAB17BC" modified="2004-07-05" version="1">MIEVNAMGQACPIPVIMAKKAVRENTGKENISVKVDNEVATQNLSKMAAQLGIGVEVNKISEKEFTVLLKAKDGVNLNPVAVPQTSSGEYAVVINSDQMGSGDEGFGKKLLEGFIYALTEQDVLPKFVVCYNSGVKLTTENEKTVNDLKALASQGCEVLSCGLCLDFYGLKEKLKVGTPTNMYRITEIMRTHFVVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q41</accession>
    <name>Q73Q41_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTP_transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971217.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681782.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0603"/>
    <dbReference type="EnsemblBacteria" id="AAS11098">
        <property type="protein sequence ID" value="AAS11098"/>
        <property type="gene ID" value="TDE_0603"/>
    </dbReference>
    <dbReference type="GeneID" id="2739159"/>
    <dbReference type="KEGG" id="tde:TDE_0603"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.583"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077108_0_0_12"/>
    <dbReference type="OMA" id="PVSMNFW"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="305" mass="34633" checksum="223743D849E98016" modified="2004-07-05" version="1">MKPTLLVLAAGMGSRYGGVKQIAAVGRHDETLLDYAVYDAMNNGFGKVVFIIREDIENDFRERFFNRIARNCNADYVFQSMDGFLTDEQIKRAVNRKKPWGTAHAILSAELKINEPFAVINADDYYGRSAYKTIATHLSTLSNDSTEHAMVGYILDKTLSRSGSVSRGVCQVGNGYLIGITEHKDIAYKKEGSVEKIVSEHEGKTVEFSGKETVSMNLFGFSPKIFDFMNEYFKDFIHKYAESEKAECLLPEGVGAMMKKGLGKVKVYTTTERWFGMTYPEDREIVKKELENKVKEGYYPEFLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q45</accession>
    <name>Q73Q45_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">TDE_0599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971213.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0599"/>
    <dbReference type="EnsemblBacteria" id="AAS11094">
        <property type="protein sequence ID" value="AAS11094"/>
        <property type="gene ID" value="TDE_0599"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0599"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.579"/>
    <dbReference type="eggNOG" id="COG1487">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118482_0_1_12"/>
    <dbReference type="OMA" id="QHFLSHS"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="128" mass="14404" checksum="47D921998509A8A0" modified="2004-07-05" version="1">MGTFLMLYLCDTCILIDYLRGKLEAQQKLQQDREQGLGMSSVTYMELMVGALNKREAGIIKKAFSDFEIVEISETISIKAKHLIEKYTKSHGLLIPDALIASTALELGLPLYTTNIKDFRFITDLILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q59</accession>
    <name>Q73Q59_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971199.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0585"/>
    <dbReference type="EnsemblBacteria" id="AAS11080">
        <property type="protein sequence ID" value="AAS11080"/>
        <property type="gene ID" value="TDE_0585"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0585"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.566"/>
    <dbReference type="eggNOG" id="ENOG5033T4C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_421464_0_0_12"/>
    <dbReference type="OMA" id="CHAAYLL"/>
    <dbReference type="OrthoDB" id="807234at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="628" mass="72539" checksum="8091B1A1BB9AAB42" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q91</accession>
    <name>Q73Q91_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971166.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681714.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0552"/>
    <dbReference type="EnsemblBacteria" id="AAS11047">
        <property type="protein sequence ID" value="AAS11047"/>
        <property type="gene ID" value="TDE_0552"/>
    </dbReference>
    <dbReference type="GeneID" id="2739797"/>
    <dbReference type="KEGG" id="tde:TDE_0552"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.537"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044830_0_0_12"/>
    <dbReference type="OMA" id="PDMVYPY"/>
    <dbReference type="OrthoDB" id="1623454at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="354" mass="40942" checksum="56E1942066AC3510" modified="2004-07-05" version="1">MITIGNIGRFESIPQILNDVLNENISALEEHLLKEWKLNKAISVGKYTELSPLDFALIMEKFQSIKWLTEKGANLNAKEHPSFLLAVRYCNEEVIRFLVSHGAKIDVTNNVGSEAFLETYYGKRFDNLSIIQELGHTAAKYGGQLLRHAVSDRNYKILEFLIEHGADINYNKSDMVYSDQSTPLCVAARYVDLEMCKFLVKHGADIKIAEKDGMRPYSIALEKGDEEMAEYFKSLEPSEFHQTQNKLDELKPYKLPKKIIEFLTGENLHFDLEDSDFGYLEFFKLIDTIPFKFGRQKLLRLSRSLGDYSHIYIVWNPKTKKIASYDMEHEELIDLAGFDDFIEDMTKYMNLILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QG8</accession>
    <name>Q73QG8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971089.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681570.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0475"/>
    <dbReference type="EnsemblBacteria" id="AAS10970">
        <property type="protein sequence ID" value="AAS10970"/>
        <property type="gene ID" value="TDE_0475"/>
    </dbReference>
    <dbReference type="GeneID" id="2740522"/>
    <dbReference type="KEGG" id="tde:TDE_0475"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.460"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072513_0_0_12"/>
    <dbReference type="OMA" id="HAESRMV"/>
    <dbReference type="OrthoDB" id="1395206at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="91"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="351" mass="39300" checksum="C0A9BDFCE3AF75B4" modified="2004-07-05" version="1">MNNEFYLSDENTEVKKLSEKSIQDILSEYPFIEDFINENRLIEIGILKNKEQTLKDFLQSLSDEVCEEEAINREELYSAFFEYIIQMKSFLNLENANEVHNLTILPGTNKSGETENFDELTLYTSQIISIVGPTGSGKSRLLADIEWTAQKDTPTNRSILINGKTPDKTIRFSVNNKLVAQLSQNMNFVMDLSVKEFIELHAESRLIQNKEDAVKNIIEAANNLAGEKFNLDTPITALSGGQSRALMIADTAILSSSPIVLIDEIENAGIDRKKALELLVSKEKIVLMATHDPALALYADKRIVIKNGGIASVIETSKKEKEILAELEIMDAKIQNMRTRLRAGEELGLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QI5</accession>
    <name>Q73QI5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971072.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0458"/>
    <dbReference type="EnsemblBacteria" id="AAS10953">
        <property type="protein sequence ID" value="AAS10953"/>
        <property type="gene ID" value="TDE_0458"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0458"/>
    <dbReference type="HOGENOM" id="CLU_3349891_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="37" mass="4413" checksum="90CE4F0D7C0026B9" modified="2004-07-05" version="1">MIKKKKSNLVFFHGKKSKKSETYFCSLYNFTLDSCNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QL5</accession>
    <name>Q73QL5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971042.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0428"/>
    <dbReference type="EnsemblBacteria" id="AAS10923">
        <property type="protein sequence ID" value="AAS10923"/>
        <property type="gene ID" value="TDE_0428"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0428"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.415"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003728_2_4_12"/>
    <dbReference type="OMA" id="CENHDEN"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="60"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="195"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="246" mass="28982" checksum="165B5D3C7BDCFDB0" modified="2004-07-05" version="1">MYYYVNEHEKALADFDKVIELNPKEDKTYYWKGLVYEYLKQYESSLVYLNKAIQLNDKNYKYYELRSLVYKQLREYDKAYSDVNVAIKLNQNNGILYSLRGLLNKYLNKYNDAIIDYNKSIELMPEFIAPYKSLLSIYLQTQNYEAGLEVANKAINIEQSWILYSTRGYLFLMLQSYNEAISDSNRAIKLNSGFADSYLTRGKAYLALKEYKKAIEDFDRAIELDSDNIDKVKQEAYEALAEMGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QR2</accession>
    <name>Q73QR2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970995.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681404.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0381"/>
    <dbReference type="EnsemblBacteria" id="AAS10876">
        <property type="protein sequence ID" value="AAS10876"/>
        <property type="gene ID" value="TDE_0381"/>
    </dbReference>
    <dbReference type="GeneID" id="2739474"/>
    <dbReference type="KEGG" id="tde:TDE_0381"/>
    <dbReference type="HOGENOM" id="CLU_1748851_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="149" mass="16660" checksum="815BBDB7D4785059" modified="2004-07-05" version="1">MLTKLLVKCYTYLMEIFAWFFLIQAGIVGAILGYFFANKIIGSGEFLYSFLGGLIFIVIAFLIESAIIPFFVILFKIYDILCENLPAKGKTEALTLVERINSTERSDNIKINQDETPMVSCSSCGENIEVSDRVCPKCGSKNELFGVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QS7</accession>
    <name>Q73QS7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Type I restriction enzyme endonuclease subunit</fullName>
            <shortName evidence="10">R protein</shortName>
            <ecNumber evidence="10">3.1.21.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hsdR-1</name>
        <name evidence="12" type="ordered locus">TDE_0366</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Subunit R is required for both nuclease and ATPase activities, but not for modification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates, ATP is simultaneously hydrolyzed.</text>
            <dbReference type="EC" id="3.1.21.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The type I restriction/modification system is composed of three polypeptides R, M and S.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HsdR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.3" evidence="10"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970980.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681375.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0366"/>
    <dbReference type="REBASE" id="6419">
        <property type="entry name" value="TdeVIP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10861">
        <property type="protein sequence ID" value="AAS10861"/>
        <property type="gene ID" value="TDE_0366"/>
    </dbReference>
    <dbReference type="GeneID" id="2741086"/>
    <dbReference type="KEGG" id="tde:TDE_0366"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.356"/>
    <dbReference type="eggNOG" id="COG0610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005762_0_1_12"/>
    <dbReference type="OMA" id="KQYEAGM"/>
    <dbReference type="OrthoDB" id="25184at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009035">
        <property type="term" value="F:type I site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007409">
        <property type="entry name" value="Restrct_endonuc_type1_HsdR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004473">
        <property type="entry name" value="Restrct_endonuc_typeI_HsdR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040980">
        <property type="entry name" value="SWI2_SNF2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04313">
        <property type="entry name" value="HSDR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18766">
        <property type="entry name" value="SWI2_SNF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00348">
        <property type="entry name" value="hsdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="284"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS10861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1039" mass="119609" checksum="CBD126A22E4A1929" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QU5</accession>
    <name>Q73QU5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970962.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681326.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0348"/>
    <dbReference type="EnsemblBacteria" id="AAS10843">
        <property type="protein sequence ID" value="AAS10843"/>
        <property type="gene ID" value="TDE_0348"/>
    </dbReference>
    <dbReference type="GeneID" id="2741244"/>
    <dbReference type="KEGG" id="tde:TDE_0348"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.337"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_42_2_12"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="198" mass="23282" checksum="4E11940E5CBAD52C" modified="2004-07-05" version="1">MAKAFTEQERIKIKEKILEAALELFHDKGTKALSIAELTKRAGIAQGSFYNFWKDKEALIMELIAYRSSQKLNYIEKKFSNSLSDPAKFLTDIIYRYSVDLMVKMQKQPVYEDAFKILEAKNRNEVHRIESLYDDFLTKLIEYWEQNGSIKRADKKGLLNAFSGSFLLCSHYYQFDKEYFNEMLLTFISGIVNKYIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QW2</accession>
    <name>Q73QW2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970945.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0331"/>
    <dbReference type="EnsemblBacteria" id="AAS10826">
        <property type="protein sequence ID" value="AAS10826"/>
        <property type="gene ID" value="TDE_0331"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0331"/>
    <dbReference type="HOGENOM" id="CLU_3384318_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="33" mass="3993" checksum="982C106A5410152C" modified="2004-07-05" version="1">MNILYFIHDENQWEPQKAEIFRGSIKHCAWLSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QY2</accession>
    <name>THYX_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="1">FDTS</shortName>
            <ecNumber evidence="1">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thymidylate synthase ThyX</fullName>
            <shortName evidence="1">TS</shortName>
            <shortName evidence="1">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thyX</name>
        <name type="ordered locus">TDE_0311</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970925.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73QY2"/>
    <dbReference type="SMR" id="Q73QY2"/>
    <dbReference type="STRING" id="243275.TDE_0311"/>
    <dbReference type="EnsemblBacteria" id="AAS10806">
        <property type="protein sequence ID" value="AAS10806"/>
        <property type="gene ID" value="TDE_0311"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0311"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.300"/>
    <dbReference type="eggNOG" id="COG1351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067790_0_0_12"/>
    <dbReference type="OMA" id="EWARLMP"/>
    <dbReference type="OrthoDB" id="896350at2"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000175582" description="Flavin-dependent thymidylate synthase">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ThyX" evidence="2">
        <location>
            <begin position="11"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="ThyX motif" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="1">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="77"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="88"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00661"/>
        </source>
    </evidence>
    <sequence length="266" mass="30847" checksum="0259024FC49E0A2E" modified="2004-07-05" version="1">MDKEFKVLDKGFIRLVDYMGTDARIVQSARVSYGEGTKTVREDAALIDYLLRNKHTSPFEQVVFTFHVKLPIFVARQWIRHRTARLNEISGRYSILKAEFYVPAGKDIALQSSDNKQGRMNEAVPQDLQNEVITSLQKQQEEIYAGYSKLLDKNIARELARINLPLSTYTEWYWQIDLHNLFHFLRLRMDAHAQKEIRDYAEVMFEICKTVTPLACASFERHEKNGVNFSAEELEAIRNLIAGKDSGLKGKELERFNEKLKSGRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QZ4</accession>
    <name>Q73QZ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mutator mutT protein</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mutT</name>
        <name evidence="6" type="ordered locus">TDE_0299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970913.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681243.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0299"/>
    <dbReference type="EnsemblBacteria" id="AAS10794">
        <property type="protein sequence ID" value="AAS10794"/>
        <property type="gene ID" value="TDE_0299"/>
    </dbReference>
    <dbReference type="GeneID" id="2740286"/>
    <dbReference type="KEGG" id="tde:TDE_0299"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.287"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_19_1_12"/>
    <dbReference type="OMA" id="HADQPGM"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003561">
        <property type="entry name" value="Mutator_MutT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00586">
        <property type="entry name" value="mutt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="8-oxo-dGTP binding" evidence="2">
        <location>
            <begin position="42"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR603561-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR603561-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="139" mass="15912" checksum="ED6220DACA825823" modified="2004-07-05" version="1">MNSKKKTKTIRVAAGIICDSLEQKKKFFATAKGYGEFKGQWEFPGGKIEDGETPEQALIREIKEELGVRVRIGALIDTIEYDYPNFHLVMYCFFCELIEGEIKLLEAESGKWLTKETLYEVSWLPADVILVARIKELIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R21</accession>
    <name>Q73R21_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970886.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681208.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0272"/>
    <dbReference type="EnsemblBacteria" id="AAS10767">
        <property type="protein sequence ID" value="AAS10767"/>
        <property type="gene ID" value="TDE_0272"/>
    </dbReference>
    <dbReference type="GeneID" id="2741565"/>
    <dbReference type="KEGG" id="tde:TDE_0272"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.263"/>
    <dbReference type="eggNOG" id="ENOG502ZIYW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102192_1_0_12"/>
    <dbReference type="OrthoDB" id="1997703at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026002">
        <property type="entry name" value="ATC_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14196">
        <property type="entry name" value="ATC_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="204" mass="23820" checksum="B46BDB2010BA35ED" modified="2004-07-05" version="1">MKYKRFYSRSGFVDSGKLTPHILEHIDAAHKEKMKLLIQELDRGAWTKKQKKRQNSSIISNIALYKTFIDNGIPAQEAKELVKEYSFYIAGKAHRILNTLFHIPGFFKLFRFFMRQGMSGEEIWISKTLVDDANEYSTDVLKCLWFDTCTHFDCPEICEIFCLCDHIVFGNIKKLQFDRSETLGMGGNKCDFCFHSKTNTVKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R28</accession>
    <name>Q73R28_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ribbon-helix-helix protein, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970879.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681198.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0264"/>
    <dbReference type="EnsemblBacteria" id="AAS10760">
        <property type="protein sequence ID" value="AAS10760"/>
        <property type="gene ID" value="TDE_0264"/>
    </dbReference>
    <dbReference type="GeneID" id="2741248"/>
    <dbReference type="KEGG" id="tde:TDE_0264"/>
    <dbReference type="eggNOG" id="COG5304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185923_0_0_12"/>
    <dbReference type="OMA" id="DKYTKHY"/>
    <dbReference type="OrthoDB" id="2066419at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025528">
        <property type="entry name" value="BrnA_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14384">
        <property type="entry name" value="BrnA_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="88" mass="10376" checksum="F5F39667A970D608" modified="2004-07-05" version="1">MERRKKKIEYSDAPKRVAESISLSERIDDFLPPPDRLIRKSEKVKITITLDCESVAFFKASAKKNNVKYQTMINEILSKYAERYKYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R53</accession>
    <name>Q73R53_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trx</name>
        <name evidence="3" type="ordered locus">TDE_0238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970854.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956703.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0238"/>
    <dbReference type="KEGG" id="tde:TDE_0238"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.232"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_3_12"/>
    <dbReference type="OMA" id="KIKICKF"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0711">Selenium</keyword>
    <keyword evidence="3" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="3">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="107" mass="11924" checksum="D4BEA0A243F6D649" modified="2008-02-26" version="2">MIMAVLDITNANFDETVKTAKPVLIDFWAPWUPGCVQLSPELQAAEAELGDKAVIAQSNVDNARELAVKFKFMSIPTLIVLKDGKEVDRHTGYMDKKSLVNFVSKHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RB8</accession>
    <name>Q73RB8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FtsK/SpoIIIE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0173</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970789.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681056.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0173"/>
    <dbReference type="EnsemblBacteria" id="AAS10670">
        <property type="protein sequence ID" value="AAS10670"/>
        <property type="gene ID" value="TDE_0173"/>
    </dbReference>
    <dbReference type="GeneID" id="2739525"/>
    <dbReference type="KEGG" id="tde:TDE_0173"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.170"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001981_11_0_12"/>
    <dbReference type="OrthoDB" id="349533at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="516"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="321"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="533"/>
            <end position="540"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS10670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="846" mass="94016" checksum="1618ACE6AAC93053" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RD6</accession>
    <name>Q73RD6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coenzyme A disulfide reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970770.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681029.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0153"/>
    <dbReference type="EnsemblBacteria" id="AAS10651">
        <property type="protein sequence ID" value="AAS10651"/>
        <property type="gene ID" value="TDE_0153"/>
    </dbReference>
    <dbReference type="GeneID" id="2741741"/>
    <dbReference type="KEGG" id="tde:TDE_0153"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.151"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_2_12"/>
    <dbReference type="OMA" id="ITHAPCG"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="463"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="565" mass="61687" checksum="FF3C3E8DA2F75AD6" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RH6</accession>
    <name>Q73RH6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970729.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666717.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0112"/>
    <dbReference type="DNASU" id="2741727"/>
    <dbReference type="EnsemblBacteria" id="AAS10610">
        <property type="protein sequence ID" value="AAS10610"/>
        <property type="gene ID" value="TDE_0112"/>
    </dbReference>
    <dbReference type="GeneID" id="2741727"/>
    <dbReference type="KEGG" id="tde:TDE_0112"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.112"/>
    <dbReference type="eggNOG" id="COG1728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125011_1_0_12"/>
    <dbReference type="OMA" id="QTRKTEN"/>
    <dbReference type="OrthoDB" id="1645991at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005585">
        <property type="entry name" value="DUF327"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024042">
        <property type="entry name" value="TM1646-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03885">
        <property type="entry name" value="DUF327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158397">
        <property type="entry name" value="SSF158397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="186" mass="20925" checksum="3F6EFD2450A9D2F4" modified="2004-07-05" version="1">MGNSVDTSNYVSALNTAAPLIAKDSHIQKNQTRKTENTKVKKQKTFLDTILDSNIQESEESYYEKKLEGLNPEERKKAVDDILAVLQDEVYSSGANLAENVNEETINKYKKAVKSFVNFALQHSLNVKAVTSGGLNPLKQRNYVIVKVIDEKIDKLTQELLFNQLEKLQILAKLDEIKGLLVNLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RJ7</accession>
    <name>Q73RJ7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma-24 factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970708.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666766.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0091"/>
    <dbReference type="EnsemblBacteria" id="AAS10589">
        <property type="protein sequence ID" value="AAS10589"/>
        <property type="gene ID" value="TDE_0091"/>
    </dbReference>
    <dbReference type="GeneID" id="2741706"/>
    <dbReference type="KEGG" id="tde:TDE_0091"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.92"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_4_4_12"/>
    <dbReference type="OMA" id="TNNDYEK"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="117"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="180" mass="20636" checksum="BA52FF12ACCBCBA5" modified="2004-07-05" version="1">MFKGKGILRATSDEDFRAIYEALMPVIYKVAYNIVREGDIAEDICHDSLIKMTEKKMEFPSIDDAKYWLIRVTRNASLNHVKRCGRERKAYAKALKEDTRKVDTGEEIILKQESINSVQAALEKLPKNLRAVLQLKEYGSLNYKEIGSILGISEGNVKVRVFRAREQLSKYIGESDVYMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RQ9</accession>
    <name>Q73RQ9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TraB family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970643.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680885.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0026"/>
    <dbReference type="EnsemblBacteria" id="AAS10524">
        <property type="protein sequence ID" value="AAS10524"/>
        <property type="gene ID" value="TDE_0026"/>
    </dbReference>
    <dbReference type="GeneID" id="2741641"/>
    <dbReference type="KEGG" id="tde:TDE_0026"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.28"/>
    <dbReference type="eggNOG" id="COG1916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032780_1_0_12"/>
    <dbReference type="OMA" id="WMGRRTV"/>
    <dbReference type="OrthoDB" id="639131at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14726">
        <property type="entry name" value="TraB_PrgY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005230">
        <property type="entry name" value="TraB_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046345">
        <property type="entry name" value="TraB_PrgY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21530">
        <property type="entry name" value="PTHR21530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00261">
        <property type="entry name" value="traB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="396" mass="43519" checksum="9C9795BDDB18F500" modified="2004-07-05" version="1">MDENNEKTLKRILLKDREIILLGTAHVSKESIKDVESTIREENPDCVCVELDEVRYKSLTSKDTWQQINISQVLREGKGFLLLANLVLASFQKKLGSDLGVKPGDEMKAAIEVSQELNIKTEMVDRPIHTTLKRAWAKNRGWGRSKLLATLLSAAFSNEKLEEAEIEKLKNQSAMDNMMQEMAEYLPNIKGVLIDERDRYLASKIWESSGKKIVAVLGAGHLPGTERFIKELEAGTKTTDVSDIEVIPPKSTVSKIAAWIFPIVIIGLIILGFFKGGGIKTGQMLLSFVLWNGGLAAIGAIIAMGHPLAILASFLGAPFTTINPFLGIGMISGLVQAWAKKPQVKDMENLTHDAGSFSGWYKNRITKVLLVFILSSLGSSIGTFMTVPALIANLIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RS2</accession>
    <name>FOLD_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="1">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="1">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">folD</name>
        <name type="ordered locus">TDE_0013</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="1"/>
    <dbReference type="EC" id="3.5.4.9" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970630.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666926.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73RS2"/>
    <dbReference type="SMR" id="Q73RS2"/>
    <dbReference type="STRING" id="243275.TDE_0013"/>
    <dbReference type="EnsemblBacteria" id="AAS10511">
        <property type="protein sequence ID" value="AAS10511"/>
        <property type="gene ID" value="TDE_0013"/>
    </dbReference>
    <dbReference type="GeneID" id="2741628"/>
    <dbReference type="KEGG" id="tde:TDE_0013"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.15"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_12"/>
    <dbReference type="OMA" id="HIVGRPM"/>
    <dbReference type="OrthoDB" id="1449514at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000268551" description="Bifunctional protein FolD">
        <location>
            <begin position="1"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <sequence length="293" mass="31292" checksum="9D21F54814DCB908" modified="2004-07-05" version="1">MSAKIIDGARIAADLRADIAKDVEKIKAKGVQPTLAVILVGNDPASQSYVKGKTNALHEVGMNDRTFRLPETTTQDELLKLIKELNADKLINGILVQLPLPKQIDPDAVIEAINPEKDVDGFHPVNVGKLLLGHDTFIPCTPHGVIHLLKRTGVETKGAKVVIVGRSNIVGKPLSVLMMNKDVNATVTVCHSGTKNLTEVTKEADILVAAMGKPRFIKADMIKKGAVVIDVGVNRIDDSTKKSGFRLVGDVDFEPACEIASAITPVPKGVGPMTIAMLVANTLIAAKRQNGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F7IU54</accession>
    <name>F7IU54_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FliO/MopB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973359.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680827.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2761"/>
    <dbReference type="EnsemblBacteria" id="AAS13278">
        <property type="protein sequence ID" value="AAS13278"/>
        <property type="gene ID" value="TDE_2761"/>
    </dbReference>
    <dbReference type="GeneID" id="2740728"/>
    <dbReference type="KEGG" id="tde:TDE_2761"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2605"/>
    <dbReference type="eggNOG" id="COG3190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105449_0_0_12"/>
    <dbReference type="OrthoDB" id="2004157at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022781">
        <property type="entry name" value="Flagellar_biosynth_FliO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04347">
        <property type="entry name" value="FliO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03500">
        <property type="entry name" value="FliO_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003355889" description="Flagellar protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS13278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="219" mass="23735" checksum="F7184252044541DD" modified="2011-07-27" version="1">MSLGKKLFFIIFFLFSVTLFAENDGTSSDGDSLPSESGILLDAGKKGNIERNEGDALPAGNGSAFDLNVAERTQSPISRLLQVLVSLIIVCILAYVVLKFLKKSSLSFSSDSPYLKSVASINIAQGKSIHVITLGEKAYIVGVTDASINMIGEVEDKTLVDTMNLDAERRSSSPKQDFASMLSSVFKGSKNNDVDVNFFKAQRERLNKAAKAQVPEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F7IUZ4</accession>
    <name>F7IUZ4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Flagellar hook protein FlgE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flgE</name>
        <name evidence="7" type="ordered locus">TDE_2768</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973366.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680830.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="F7IUZ4"/>
    <dbReference type="STRING" id="243275.TDE_2768"/>
    <dbReference type="EnsemblBacteria" id="AAS13285">
        <property type="protein sequence ID" value="AAS13285"/>
        <property type="gene ID" value="TDE_2768"/>
    </dbReference>
    <dbReference type="GeneID" id="2740735"/>
    <dbReference type="KEGG" id="tde:TDE_2768"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2612"/>
    <dbReference type="eggNOG" id="COG1749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013687_2_4_12"/>
    <dbReference type="OMA" id="GLQNHQT"/>
    <dbReference type="OrthoDB" id="704242at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.98.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011491">
        <property type="entry name" value="Falgellar_hook_FlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037058">
        <property type="entry name" value="Falgellar_hook_FlgE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07559">
        <property type="entry name" value="FlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="4">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="FlaE" evidence="6">
        <location>
            <begin position="200"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="5">
        <location>
            <begin position="384"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS13285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="463" mass="49574" checksum="E872E4C726F6C733" modified="2011-07-27" version="1">MMRSLFSGVTGMQNHQTRMDVIGNNVANVNTTGFKRGRVNFQDLISQQLSGAARPTEELGGVNPKEVGLGMMVASIDTIFTQGALQTTGVNTDLAIQGNGFFILKDGEKTFYTRAGAFGIDKEGTLVNPANGMRVQGWMAEEAEGFRIINTSGQTEDLNIPIGQKLDAKATTSVNYACNLDKRLPELPEGANRAQILESTWSTEFKVYDSFGEAHELQIDFARVPGEVNAWRATVNVDPTNADATATRVGIGTTDGVQNSFIVRFDNNGHLASVTDTAGNVTSPAGQVLVQISYNVVGANPDEAGAPTRHTFDVNLGEIGTSKNTITQFSDKSTTKAYEQDGYTLGYLENFRIDQSGIITGVYSNGVRQEIGQIAMAGFANQGGLEKAGQNTYVQSNNSGIANVSTSGTVGKGYFIGGTLEMSNVDLTDQFVDMIVTQKGFQAGAKTIQTSDTMLETVLNLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F7IW81</accession>
    <name>F7IW81_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chemotaxis protein CheX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheX</name>
        <name evidence="3" type="ordered locus">TDE_1493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972099.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668974.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1493"/>
    <dbReference type="EnsemblBacteria" id="AAS12010">
        <property type="protein sequence ID" value="AAS12010"/>
        <property type="gene ID" value="TDE_1493"/>
    </dbReference>
    <dbReference type="GeneID" id="2739894"/>
    <dbReference type="KEGG" id="tde:TDE_1493"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1432"/>
    <dbReference type="eggNOG" id="COG1406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116290_1_0_12"/>
    <dbReference type="OMA" id="NVEYINP"/>
    <dbReference type="OrthoDB" id="1956590at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038756">
        <property type="entry name" value="CheX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39452">
        <property type="entry name" value="PTHR39452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheX" evidence="2">
        <location>
            <begin position="42"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="154" mass="16846" checksum="3D25A7375A106A06" modified="2011-07-27" version="1">MRVEYINPFSEAAYNILSQVLSEDIKRGDLYLKSTCMPVMGVAAIVGLAGDVEGRVIFDMTLDTALKIASAMNNEELAEFDELARATITELANLITAQAVTKLHDLGFKFDLTPPALFTGENMKISNNDIEALIVPMTAPQGRVEINVAIRDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F7IWF6</accession>
    <name>F7IWF6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Major outer sheath protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Major surface protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0405</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405</strain>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2017" name="Mol. Oral. Microbiol." volume="0" first="0" last="0">
            <title>Oral Treponeme Major Surface Protein: Sequence Diversity and Distributions within Periodontal Niches.</title>
            <authorList>
                <person name="You M."/>
                <person name="Chan Y."/>
                <person name="Lacap-Bugler D.C."/>
                <person name="Huo Y.B."/>
                <person name="Gao W."/>
                <person name="Keung Leung W."/>
                <person name="Watt R.M."/>
            </authorList>
            <dbReference type="PubMed" id="28453906"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">ATCC 35405</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KJ671481">
        <property type="protein sequence ID" value="AMD40771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JC6005">
        <property type="entry name" value="JC6005"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971019.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681434.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="F7IWF6"/>
    <dbReference type="STRING" id="243275.TDE_0405"/>
    <dbReference type="TCDB" id="1.B.38.1.4">
        <property type="family name" value="the treponema porin major surface protein (tp-msp) family"/>
    </dbReference>
    <dbReference type="DNASU" id="2740151"/>
    <dbReference type="EnsemblBacteria" id="AAS10900">
        <property type="protein sequence ID" value="AAS10900"/>
        <property type="gene ID" value="TDE_0405"/>
    </dbReference>
    <dbReference type="GeneID" id="2740151"/>
    <dbReference type="KEGG" id="tde:TDE_0405"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.392"/>
    <dbReference type="eggNOG" id="ENOG50318T1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021037_0_0_12"/>
    <dbReference type="OMA" id="TWGINLG"/>
    <dbReference type="OrthoDB" id="570214at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003872">
        <property type="entry name" value="MOSP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003857">
        <property type="entry name" value="MOSP_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02722">
        <property type="entry name" value="MOSP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02707">
        <property type="entry name" value="MOSP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833286" evidence="1">
        <location>
            <begin position="21"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="MOSP_N" evidence="2">
        <location>
            <begin position="113"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="MOSP_C" evidence="3">
        <location>
            <begin position="364"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AMD40771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="543" mass="58270" checksum="AFADADBBA55737FF" modified="2011-07-27" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2001-06-01" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>O87546</accession>
    <name>DNAA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">dnaA</name>
        <name type="ordered locus">TDE_0001</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2000" name="Gene" volume="253" first="259" last="269">
            <title>Molecular characterization of the gyrB region of the oral spirochete, Treponema denticola.</title>
            <authorList>
                <person name="Greene S.R."/>
                <person name="Stamm L.V."/>
            </authorList>
            <dbReference type="PubMed" id="10940564"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(00)00254-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="AF083949">
        <property type="protein sequence ID" value="AAC62071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970618.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680852.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O87546"/>
    <dbReference type="SMR" id="O87546"/>
    <dbReference type="STRING" id="243275.TDE_0001"/>
    <dbReference type="PRIDE" id="O87546"/>
    <dbReference type="EnsemblBacteria" id="AAS10499">
        <property type="protein sequence ID" value="AAS10499"/>
        <property type="gene ID" value="TDE_0001"/>
    </dbReference>
    <dbReference type="GeneID" id="2741619"/>
    <dbReference type="KEGG" id="tde:TDE_0001"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026910_3_1_12"/>
    <dbReference type="OMA" id="REFNPLF"/>
    <dbReference type="OrthoDB" id="219876at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000114290" description="Chromosomal replication initiator protein DnaA">
        <location>
            <begin position="1"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="469" mass="53782" checksum="80F56A05C393DFD2" modified="1998-11-01" version="1">MSEWDYKIFWDEAVNQFKEELAFSIFSMWFLPSKYEKSTENTVYLSVPSKFFRDQMIHNYKNGIEKKLFELSGKKISIDFIIKPNTSEDLSKAENEGGNDKKEDAAKPSSAESKKKSVKTEGGRGQHPDLRPEYNFEDFVVGPNNNFGVNAAIAVSTNPGSAYNPFLIYGGVGLGKTHLMQAIGNKIWDTTKLKVIYVTAENFTNEFVECVQKKMMPAFKSKYRKADVLLIDDIHFFQGKVETQEELFHTFNELYEKNKQIVFTCDRPPAELKNLSQRLKSRFERGLNVDLQTPAYEIRYAILLKKMEKHSTKIPNEFIDMVAKNVSSNVRDLEAALTKLIAYTELTKKTMDEATAKNLLRDIFGSTRQRNVTIDLIQRTVADYFSISISDIKSKKRTKSFSFPRQIAMFLCREMTECSTTELGNDFGGRDHTTILHGCNKIEEQIAADPSLEKIIHELRNTIKENTNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-24" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>P61478</accession>
    <name>HSLV_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent protease subunit HslV</fullName>
            <ecNumber evidence="1">3.4.25.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hslV</name>
        <name type="ordered locus">TDE_1210</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent cleavage of peptide bonds with broad specificity.</text>
            <dbReference type="EC" id="3.4.25.2"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by HslU binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase T1B family. HslV subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.2" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971817.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668456.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61478"/>
    <dbReference type="SMR" id="P61478"/>
    <dbReference type="STRING" id="243275.TDE_1210"/>
    <dbReference type="MEROPS" id="T01.006"/>
    <dbReference type="EnsemblBacteria" id="AAS11728">
        <property type="protein sequence ID" value="AAS11728"/>
        <property type="gene ID" value="TDE_1210"/>
    </dbReference>
    <dbReference type="GeneID" id="2740104"/>
    <dbReference type="KEGG" id="tde:TDE_1210"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1165"/>
    <dbReference type="eggNOG" id="COG5405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093872_1_0_12"/>
    <dbReference type="OMA" id="IMKGNAR"/>
    <dbReference type="OrthoDB" id="1129370at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01913">
        <property type="entry name" value="protease_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00248">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022281">
        <property type="entry name" value="ATP-dep_Prtase_HsIV_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="PTHR32194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039093">
        <property type="entry name" value="HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03692">
        <property type="entry name" value="ATP_dep_HslV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0915">Sodium</keyword>
    <keyword id="KW-0888">Threonine protease</keyword>
    <feature type="chain" id="PRO_0000148156" description="ATP-dependent protease subunit HslV">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00248"/>
        </source>
    </evidence>
    <sequence length="178" mass="19231" checksum="7CB803A819F734FB" modified="2004-05-24" version="1">MSQKIRSTTVIAVRKDGKIVMAGDGQVTMGETVMKGNARKVRKIYDGKIITGFAGATADAFTLLEKFEIRVKEFSGDLTRAAVELAKDWRTDKMLKNLQALLLVADSKTTLLISGNGDVIEPEEDVLAIGSGGNYAYASALALMQNTNLSAREIAEKSLQIAGKICIYTNGKIITEEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-09-21" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J26</accession>
    <name>HFLX_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hflX</name>
        <name type="ordered locus">TDE_2750</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973348.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667011.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73J26"/>
    <dbReference type="SMR" id="Q73J26"/>
    <dbReference type="STRING" id="243275.TDE_2750"/>
    <dbReference type="EnsemblBacteria" id="AAS13267">
        <property type="protein sequence ID" value="AAS13267"/>
        <property type="gene ID" value="TDE_2750"/>
    </dbReference>
    <dbReference type="GeneID" id="2740717"/>
    <dbReference type="KEGG" id="tde:TDE_2750"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2596"/>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_2_1_12"/>
    <dbReference type="OMA" id="AEMKTGR"/>
    <dbReference type="OrthoDB" id="1592033at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000412664" description="GTPase HflX">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Hflx-type G" evidence="1">
        <location>
            <begin position="222"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="228"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="253"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="278"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="344"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="369"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="391" mass="43571" checksum="7B2955ECA7FED328" modified="2004-07-05" version="1">MYITDNETKKALLIFTDIFSGPASNSHISRSTLQEKSAKALKEIEEKELKSLVETIFLKPLSSLRFRIAKENPATLVGSGQLEKIAQAIEEEGADLVVFNSAVSPRIQRNLEAALNTCVIDRSEVIIQIFADRAQTREAVLQAELARLEYSMPRLTRRWTSLAQQRGGAKGTRGASRGAGEKKLELDRRRLKTEITKLKKEVERVRLQRSEQRKTRLNGDKKIGAIVGYTNAGKSSLLKKLSGAEVFTEDKLFATLDAETRKVFLQTGEKNIQILLTDTVGFVSNLPHQLIDAFRSTLEEAALADFLIIVCDAAHPAMPECLEVTKKVLDELSCSDKPSIIAINKMDDIFDEAQLLNLKERYPEAVEISVTTGQGLEGLKKKITDIIIFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J63</accession>
    <name>Q73J63_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase, TrmH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973311.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957298.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2713"/>
    <dbReference type="EnsemblBacteria" id="AAS13230">
        <property type="protein sequence ID" value="AAS13230"/>
        <property type="gene ID" value="TDE_2713"/>
    </dbReference>
    <dbReference type="GeneID" id="2740932"/>
    <dbReference type="KEGG" id="tde:TDE_2713"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2562"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_2_0_12"/>
    <dbReference type="OMA" id="NRAEEMK"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="255" mass="28557" checksum="C032D5CFE0C22697" modified="2004-07-05" version="1">MGKKFEKELPVCGFESCLALAKHHPEKISRLFFSEKRAKQFGEVCKYLASNKRLYRIVSDDELEKLSESVHHQGVTAMIFEPEIPVLEHEEINLWAQNKEHVLMLDEIGNANNLGAIIRSAAFFGIENIVLTKEDKQASITTSAYRVAQGGMEFVKIFKVSSTAWFLRQCRGRLTCIGTDLRAHHEIADLGRLIEKDEACVIVLGNEERGISEEAKKLCVHLIKIKGSGNVESLNVAQAATLFCHSLSATNPRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J80</accession>
    <name>Q73J80_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973294.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667094.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2696"/>
    <dbReference type="EnsemblBacteria" id="AAS13213">
        <property type="protein sequence ID" value="AAS13213"/>
        <property type="gene ID" value="TDE_2696"/>
    </dbReference>
    <dbReference type="GeneID" id="2739283"/>
    <dbReference type="KEGG" id="tde:TDE_2696"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2546"/>
    <dbReference type="eggNOG" id="COG3063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_891215_0_0_12"/>
    <dbReference type="OMA" id="CVKFWIN"/>
    <dbReference type="OrthoDB" id="1229969at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="312" mass="36538" checksum="104C721FF6F1039F" modified="2004-07-05" version="1">MSERPVQSKLNNALNILKQGDLRGSYAELERLLRDDLENAEIDYTLKGVRFWEDKLEKAKKASTPLERAEMMISQWKPFLAYIHRQGEEKESIIYSLKCAVFTIALEFYADLFNEESELPDAEPYRKIGLCYKVLGNYERALDFLRYAAEIDKNSGSVLADLADCYALYGEIKFAKAFFREAFFIDPEGIELQFLESEIICRLINRVYNLGYRVEDIADWLPIYGVIDGVFNVKRELRAFEVGQLKQNIFLMEGEVQNASQEQKHKLVPRLINHYFWLIDHYVSVNESKSKIDDLLLRIKVLDQNIYNCYMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JB4</accession>
    <name>Q73JB4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CxxC_CXXC_SSSS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973259.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667146.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2661"/>
    <dbReference type="EnsemblBacteria" id="AAS13178">
        <property type="protein sequence ID" value="AAS13178"/>
        <property type="gene ID" value="TDE_2661"/>
    </dbReference>
    <dbReference type="GeneID" id="2741106"/>
    <dbReference type="KEGG" id="tde:TDE_2661"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2515"/>
    <dbReference type="eggNOG" id="COG2331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136025_3_1_12"/>
    <dbReference type="OMA" id="TYQYQCT"/>
    <dbReference type="OrthoDB" id="1914830at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="82" mass="8612" checksum="1E43DB64BE950941" modified="2004-07-05" version="1">MPTYEYVCDSCGHDFEVFQRMSDEPVSVCPECGKPVRRVISGGLGINFRGSGFYVNDSSSAPKAASGGCSGCSSSSCSTCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JC9</accession>
    <name>Q73JC9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973244.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680678.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2646"/>
    <dbReference type="EnsemblBacteria" id="AAS13163">
        <property type="protein sequence ID" value="AAS13163"/>
        <property type="gene ID" value="TDE_2646"/>
    </dbReference>
    <dbReference type="GeneID" id="2741091"/>
    <dbReference type="KEGG" id="tde:TDE_2646"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2501"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="LMVTHNV"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="200" mass="22419" checksum="C40093E64F2538DD" modified="2004-07-05" version="1">MEKPIKIHEGTFYYSKHKVFQNLNIEIPVQKITCILGESGAGKSTLLKIISGNLELKSGRIENRPDRGSYAMAYQDMRLIPHLTAVENIEYVLDSKPSSKTENKKKALFYLEALGLSGFKNFLPTELSGGMQRRAGLARALSYPAPLLLLDEAFDSLDEKNKYKVADLFLSIVKKEKRTAVCVTHDAPFAKKIADKIIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JE7</accession>
    <name>Q73JE7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973226.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2628"/>
    <dbReference type="EnsemblBacteria" id="AAS13145">
        <property type="protein sequence ID" value="AAS13145"/>
        <property type="gene ID" value="TDE_2628"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2628"/>
    <dbReference type="HOGENOM" id="CLU_2866491_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284885" evidence="2">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="64" mass="6889" checksum="87F1CFFC5C65D2E3" modified="2004-07-05" version="1">MAVLSLGISLLFLYTALANTCKYTTNPFCCQDGEGKVANKPGITKPNSTRTNSQKTGSQNYLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JF0</accession>
    <name>Q73JF0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973223.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680643.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2625"/>
    <dbReference type="EnsemblBacteria" id="AAS13142">
        <property type="protein sequence ID" value="AAS13142"/>
        <property type="gene ID" value="TDE_2625"/>
    </dbReference>
    <dbReference type="GeneID" id="2740799"/>
    <dbReference type="KEGG" id="tde:TDE_2625"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2482"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_12"/>
    <dbReference type="OMA" id="SNISMVF"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="39"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="335"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS13142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="579" mass="63890" checksum="11A022D2CFFC9859" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JF3</accession>
    <name>Q73JF3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973220.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680630.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2622"/>
    <dbReference type="TCDB" id="3.A.1.31.2">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13139">
        <property type="protein sequence ID" value="AAS13139"/>
        <property type="gene ID" value="TDE_2622"/>
    </dbReference>
    <dbReference type="GeneID" id="2740796"/>
    <dbReference type="KEGG" id="tde:TDE_2622"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2478"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_12"/>
    <dbReference type="OrthoDB" id="870493at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="269"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="303"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="470" mass="52267" checksum="D8952F02690DD955" modified="2004-07-05" version="1">MVELKNVSFRYGSENVECKYASSLKSIDLTVKTGECVLLTGPSGCGKTTILRLINGLIPHFYPGALSGDILIDGGSVKERELYDTALIIGTVFQNPRTQFYNVDTTGELAFGCENRGLPEQEIYTRIDRTVAHFRMASLMDRNIFRLSDGEKQKIACASVNVSEPKIILLDEPSANLDYTATLMLRELILRWKAEGKTIIAAEHRIAYLWDIIDRAVVLRDGEIVEEFTGNGKEELTQNQLTQMGLRTTVMESPAEMQMDSFREGDRPITLRNFHFAYHGEKKNIVDIPMLQIAAGQITAIVGANGAGKTSFLNCLCGLEKRCKGTLEYEGKLYDSKSRKKLCFMVMQDTGNQLFTESVLDEVLISLKKGTANEKETAMEIIRNLDLADFADRHPQSLSGGQKQRLAIACALASGRELLLLDEPTSGLDYAHMKETAALLEKLRSMGTTILVVTHDSELIRACCTRRITV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-02" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JL8</accession>
    <name>RL34_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmH</name>
        <name type="ordered locus">TDE_2400</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972999.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667651.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JL8"/>
    <dbReference type="SMR" id="Q73JL8"/>
    <dbReference type="STRING" id="243275.TDE_2400"/>
    <dbReference type="EnsemblBacteria" id="AAS12918">
        <property type="protein sequence ID" value="AAS12918"/>
        <property type="gene ID" value="TDE_2400"/>
    </dbReference>
    <dbReference type="GeneID" id="2740702"/>
    <dbReference type="KEGG" id="tde:TDE_2400"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2266"/>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_2_0_12"/>
    <dbReference type="OMA" id="RMASVNG"/>
    <dbReference type="OrthoDB" id="2069770at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000187495" description="50S ribosomal protein L34">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="51" mass="6025" checksum="C17DF87004A1052E" modified="2004-07-05" version="1">MKRTYQPSKTKRVRRFGFRALMKTKGGRAVLSRRRAKGRRKLSASDEKKPF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JM1</accession>
    <name>YIDC_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidC</name>
        <name type="ordered locus">TDE_2396</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972995.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680325.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JM1"/>
    <dbReference type="SMR" id="Q73JM1"/>
    <dbReference type="STRING" id="243275.TDE_2396"/>
    <dbReference type="PRIDE" id="Q73JM1"/>
    <dbReference type="EnsemblBacteria" id="AAS12914">
        <property type="protein sequence ID" value="AAS12914"/>
        <property type="gene ID" value="TDE_2396"/>
    </dbReference>
    <dbReference type="GeneID" id="2740698"/>
    <dbReference type="KEGG" id="tde:TDE_2396"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2263"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016535_2_0_12"/>
    <dbReference type="OMA" id="MPIMFFF"/>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01810">
        <property type="entry name" value="YidC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019998">
        <property type="entry name" value="Membr_insert_YidC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028053">
        <property type="entry name" value="Membr_insert_YidC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038210">
        <property type="entry name" value="YidC_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038221">
        <property type="entry name" value="YidC_periplasmic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14849">
        <property type="entry name" value="YidC_periplas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01900">
        <property type="entry name" value="YIDCPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03593">
        <property type="entry name" value="yidC_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000070185" description="Membrane protein insertase YidC">
        <location>
            <begin position="1"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01810"/>
        </source>
    </evidence>
    <sequence length="582" mass="66068" checksum="BAAC0F8DE99EE700" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JM2</accession>
    <name>Q73JM2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Jag protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2395</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972994.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667657.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2395"/>
    <dbReference type="EnsemblBacteria" id="AAS12913">
        <property type="protein sequence ID" value="AAS12913"/>
        <property type="gene ID" value="TDE_2395"/>
    </dbReference>
    <dbReference type="GeneID" id="2740697"/>
    <dbReference type="KEGG" id="tde:TDE_2395"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2262"/>
    <dbReference type="eggNOG" id="COG1847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042512_0_1_12"/>
    <dbReference type="OMA" id="RRVQKWP"/>
    <dbReference type="OrthoDB" id="1304273at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02414">
        <property type="entry name" value="jag_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02644">
        <property type="entry name" value="R3H_jag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038008">
        <property type="entry name" value="Jag_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038247">
        <property type="entry name" value="Jag_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039247">
        <property type="entry name" value="KhpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032782">
        <property type="entry name" value="KhpB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034079">
        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35800">
        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="R3H" evidence="7">
        <location>
            <begin position="169"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="236" mass="27040" checksum="F635249422226B5D" modified="2004-07-05" version="1">MIYEFEGKTEREAIDIAVAKLGLEKDQFDVEILEIQKNSLFKKGHAKIRVHVDESLRANMKNNSEQAEEEQTLKEDKDLRTSEDVSEGAEKTRLFIQTLVEKIGYDCSVSLIACDKKHFSYRINSKDAAMLIGKKGKNLDSIQLLANVYAGTIGHAYARVSVDCESYRIRREELLIRMAYDVADKVRMTKKSQLLEPLNPYERRIIHTTLNAVNDIETKSEGDGLYKQVRVFYKGI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JR4</accession>
    <name>METK_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-adenosylmethionine synthase</fullName>
            <shortName evidence="1">AdoMet synthase</shortName>
            <ecNumber evidence="1">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metK</name>
        <name type="ordered locus">TDE_2470</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973068.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680429.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JR4"/>
    <dbReference type="SMR" id="Q73JR4"/>
    <dbReference type="STRING" id="243275.TDE_2470"/>
    <dbReference type="EnsemblBacteria" id="AAS12987">
        <property type="protein sequence ID" value="AAS12987"/>
        <property type="gene ID" value="TDE_2470"/>
    </dbReference>
    <dbReference type="GeneID" id="2739655"/>
    <dbReference type="KEGG" id="tde:TDE_2470"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2336"/>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_12"/>
    <dbReference type="OMA" id="MPYLRPD"/>
    <dbReference type="OrthoDB" id="1024388at2"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000174616" description="S-adenosylmethionine synthase">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="252"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <sequence length="389" mass="42736" checksum="9A2746F5D9EE1E5C" modified="2004-07-05" version="1">MKNDINYFTSESVSEGHPDKLCDQISDAVLDACLRDDPESHVACETFASTALVLVGGEITTNTYVDIQEIARSIAEEIGYTNTDFGLDCHSMAVMNMIHSQSPDISQGVDGTGLDEYKGQQGAGDQGMMFGFACKETPELMPAPIMFSHSVLRYAAKLRKEKVIPWLRPDSKTQITVKYEGFKPIKIDTVVLSHQHYPDVQYDELKDTLINRVIKPVLGPTGLLADDTKYFINPTGRFVIGGPFGDTGLTGRKIIVDTYGGMGRHGGGAFSGKDPSKVDRSAAYMARYIAKNVVAADLARRCEVQLAYAIGVPFPVAVRVDTFGTGEVPEEKIEKAIKEVFDMSPAGIIKTLDLKRPIYKETAAYGHFGRPEFSWEKTDKTEALKKAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JR6</accession>
    <name>Q73JR6_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="TDE_2468"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2468"/>
    <dbReference type="HOGENOM" id="CLU_2830002_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="66" mass="7795" checksum="EA25F5E3BC2A972D" modified="2004-07-05" version="1">MGDNEFFKINLQKGYKDNFEGIKKKAAEKAKFAKGPSFLFPYYKPEVKLPRRYKLIYAFRSPITKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JU2</accession>
    <name>Q73JU2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973091.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2493"/>
    <dbReference type="EnsemblBacteria" id="AAS13010">
        <property type="protein sequence ID" value="AAS13010"/>
        <property type="gene ID" value="TDE_2493"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2493"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2359"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_1_2_12"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="318"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="539" mass="60973" checksum="751D76266C2281F7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JU7</accession>
    <name>Q73JU7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine/threonine protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973112.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680480.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2514"/>
    <dbReference type="EnsemblBacteria" id="AAS13031">
        <property type="protein sequence ID" value="AAS13031"/>
        <property type="gene ID" value="TDE_2514"/>
    </dbReference>
    <dbReference type="GeneID" id="2739026"/>
    <dbReference type="KEGG" id="tde:TDE_2514"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2380"/>
    <dbReference type="eggNOG" id="COG2129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041441_5_0_12"/>
    <dbReference type="OMA" id="AVPGNCD"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07392">
        <property type="entry name" value="MPP_PAE1087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041733">
        <property type="entry name" value="PAE1087_MPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="225" mass="24180" checksum="A6193C6FC02C3BE4" modified="2004-07-05" version="1">MKLLIISDGHGDLEKLKKIKPVADGVDALIFGGDFAAFKKIETGAPFLNELLKIHKNIFAVLGNCDEPEFEKKLKDASVSITGEVKNFEGLIFAGSGGGSKFTGTTPYERTDEELVKDLTDAFEKANITAAGNLVLVCHNPPHGAKVDKVAPMVHVGSKGITAFIEKHKPLLVVSGHIHESFAVDKIGETVLVNPGALMEGRYALAEITKNEKGFKVSVELKTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JW7</accession>
    <name>Q73JW7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973118.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675974.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2520"/>
    <dbReference type="EnsemblBacteria" id="AAS13037">
        <property type="protein sequence ID" value="AAS13037"/>
        <property type="gene ID" value="TDE_2520"/>
    </dbReference>
    <dbReference type="GeneID" id="2739032"/>
    <dbReference type="KEGG" id="tde:TDE_2520"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2385"/>
    <dbReference type="eggNOG" id="COG3577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643941_0_0_12"/>
    <dbReference type="OMA" id="SISCEMM"/>
    <dbReference type="OrthoDB" id="550720at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05483">
        <property type="entry name" value="retropepsin_like_bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034122">
        <property type="entry name" value="Retropepsin-like_bacterial"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284893" evidence="1">
        <location>
            <begin position="28"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="426" mass="47666" checksum="22011D72971C8DEE" modified="2004-07-05" version="1">MKQNQCKLIKMLSAFLIFFCFFGGIFAQNEAECEKAVQALAEACNEKSVTNVLPYLAEDFSIAGQSGNRAKAILQQLLAGVGTVISYEKTESLMEDGKLILKYSIEYSQVGKKESVFIFNKDNLIVEAELMKIKVKTLSSEERTIEYNTNKITSIPFIFAGNLPLVDVLLEGKSRLFLLDSGAPFSILNSKYIEGLNTDTKKLGSFQDVSGNVSSPNMDITNVKELEFAGSKIKNQKIVVLDMTRLEQSLKTDGIYGLIGYDMLKEYDVFLDYQKKRLTLIRPDSYDSFIKANTLKVDSKIPCKMAGHIPAIEVSIGNKIYKLGLDTGAEFNLLDSFYFNELEPSLTNKEKTELSGAGGIKQEIYQAELKTMKIGGKTYKNVKTVFSDISHLRKKPDSYDGLLGYPFFSAQPTLISYRRGEIILFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JY6</accession>
    <name>Q73JY6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="9">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">lysS</name>
        <name evidence="11" type="ordered locus">TDE_2553</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="9"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973151.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680521.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2553"/>
    <dbReference type="EnsemblBacteria" id="AAS13070">
        <property type="protein sequence ID" value="AAS13070"/>
        <property type="gene ID" value="TDE_2553"/>
    </dbReference>
    <dbReference type="GeneID" id="2739918"/>
    <dbReference type="KEGG" id="tde:TDE_2553"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2413"/>
    <dbReference type="eggNOG" id="COG1384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025562_1_0_12"/>
    <dbReference type="OMA" id="DWPMRWA"/>
    <dbReference type="OrthoDB" id="256927at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00177">
        <property type="entry name" value="Lys_tRNA_synth_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002904">
        <property type="entry name" value="Lys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042078">
        <property type="entry name" value="Lys-tRNA-ligase_SC_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940">
        <property type="entry name" value="PTHR37940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01921">
        <property type="entry name" value="tRNA-synt_1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00467">
        <property type="entry name" value="lysS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="36"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS13070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="528" mass="60882" checksum="255032BB5F3450EB" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K11</accession>
    <name>Q73K11_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chaperonin, 33 kDa family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973152.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2554"/>
    <dbReference type="EnsemblBacteria" id="AAS13071">
        <property type="protein sequence ID" value="AAS13071"/>
        <property type="gene ID" value="TDE_2554"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2554"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2414"/>
    <dbReference type="eggNOG" id="COG1281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054493_1_0_12"/>
    <dbReference type="OMA" id="DMQCECC"/>
    <dbReference type="OrthoDB" id="1406579at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000397">
        <property type="entry name" value="Heat_shock_Hsp33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016154">
        <property type="entry name" value="Heat_shock_Hsp33_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016153">
        <property type="entry name" value="Heat_shock_Hsp33_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30111">
        <property type="entry name" value="PTHR30111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01430">
        <property type="entry name" value="HSP33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005261">
        <property type="entry name" value="Heat_shock_Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118352">
        <property type="entry name" value="SSF118352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64397">
        <property type="entry name" value="SSF64397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS13071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="292" mass="32936" checksum="00A4914B9DF3EA4D" modified="2004-07-05" version="1">MHEDGMTVFMLGEGQIRGAFFHGTRFVNKMRVQHNLGILESLALGHASLCGALLIPTMKGRDRIIFRCDTQGPLVGFSVEAFSEGFVRGYLLEDPIRPDRPLETWDLKPLFGEGKISVIRFPEGAREPLTGIVEIKHKNIALDLSEYFLQSEQTVTGFNTGIQFDKEGRIIGAGGMYIQLMPGAEEGLIEKAERAFAACPSIGQWFAEGGDREDVIFGLFRDCNPQVLIERKIDFYCPCSEENFRNKLFTLPEKEIADMYENGPEQIELYCHNCGSIYKYPKSILKEKINVH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K17</accession>
    <name>ENGB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">engB</name>
        <name type="ordered locus">TDE_2574</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973172.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680558.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73K17"/>
    <dbReference type="SMR" id="Q73K17"/>
    <dbReference type="STRING" id="243275.TDE_2574"/>
    <dbReference type="PRIDE" id="Q73K17"/>
    <dbReference type="EnsemblBacteria" id="AAS13091">
        <property type="protein sequence ID" value="AAS13091"/>
        <property type="gene ID" value="TDE_2574"/>
    </dbReference>
    <dbReference type="GeneID" id="2741278"/>
    <dbReference type="KEGG" id="tde:TDE_2574"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2433"/>
    <dbReference type="eggNOG" id="COG0218">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033732_3_0_12"/>
    <dbReference type="OMA" id="LMMDIRH"/>
    <dbReference type="OrthoDB" id="1746051at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_0000266976" description="Probable GTP-binding protein EngB">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="EngB-type G" evidence="1">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="192"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <sequence length="212" mass="23859" checksum="6C0805651D09FB4F" modified="2004-07-05" version="1">MKIINAEFIKGAVKAEQFPEIGVSEFAFFGRSNAGKSSLINMLVNRKNLVKTGSRPGMTREVNFFLVNRPASLNFNPKTKKFSGPAPKDMFVLTDLPGYGYAKLSGGMTLQIDKMLYEYCTNRPLLKIIFFLMDMRREPTETEKESIGFFHGLNIEVVIVGTKADKIGKNDQIKAKNDWADFFNFDEELIIISSAAKKTGRDNILSLIAKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K41</accession>
    <name>Q73K41_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase-related ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972980.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680308.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2381"/>
    <dbReference type="EnsemblBacteria" id="AAS12899">
        <property type="protein sequence ID" value="AAS12899"/>
        <property type="gene ID" value="TDE_2381"/>
    </dbReference>
    <dbReference type="GeneID" id="2740683"/>
    <dbReference type="KEGG" id="tde:TDE_2381"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2249"/>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_20_15_12"/>
    <dbReference type="OMA" id="INELPMA"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_3" evidence="3">
        <location>
            <begin position="184"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="382" mass="44025" checksum="09E93FDCD78D0435" modified="2004-07-05" version="1">MKNKFFIFIHYFLIASSLIQISVTGDRITGIQFLLYLCFIILFNLRLFYINNKTLFFILCLADWALCFFLYITGLTIPFLLFLIPLIDGFYYNSKPYTYILGIIGLAVCIFSLKNFDMGIIINYTALFILSGGVLEYFKLNQNKIISSQNKIEELNIQKEELLNSIHDLEIYNESIEDLMTLKERNRISREIHDSVGHGLSTMIIQLNALYAAAKNNNNDLPQKILDLNAFAKKNLEEVRFALRELKPVDYNKYEIIILVHNLIGEFKKMTNINVQFTFSKDIWSLNEKQSHAVYKAVQEFLSNSAKYSNASKITIHFSYTEASLIVTMKDNGDGCTDIKKGIGLKAIEERVKETDGTVYYESLPAVKGFFMRLAFFQNKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K79</accession>
    <name>Q73K79_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_2341</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972940.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680259.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2341"/>
    <dbReference type="EnsemblBacteria" id="AAS12859">
        <property type="protein sequence ID" value="AAS12859"/>
        <property type="gene ID" value="TDE_2341"/>
    </dbReference>
    <dbReference type="GeneID" id="2739436"/>
    <dbReference type="KEGG" id="tde:TDE_2341"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2209"/>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025778_0_0_12"/>
    <dbReference type="OMA" id="QYMVGFG"/>
    <dbReference type="OrthoDB" id="1395197at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="185"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS12859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="450" mass="49166" checksum="27D1C88249D8705E" modified="2004-07-05" version="1">MVKILIGLIILSIMVFIHELGHFIAAKLCGVVVESFSIGWGPVLFKKKKGDTEYRISAIPMGGYCGMKGEKAFQQAIEENLPAIPKKEGELYGVHPFKRIIIAFAGPFANYISAVLALAIVSAIGSSYYTSSNKIAPVYYYNEADDSPAREADLRMGDVILSINSEKTETFADIVRLIVPEAKEEVTLEIEREGQILTKKLRPKLDPKTGAGIIGFYSFIPLEIDGVKPSSSAELAGLKKGDLITEVNGIEVANTVDLNRALDGISGKTAELGILRDGNKITKTVNLIRTENGIDLGLNIKNIKVEIPGTGIFKSIVNGFVLTHKAFILTFKSLGLLFKGVDFRQAVSGPVRITHMLGDVAAQGFKAGFLIGLSDILNFVSIISISLFIMNLLPIPILDGGLILFAFIEFIFRRQIHPKVLYYVQFIGIAFIGIVFIFALWGDIGYFLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K89</accession>
    <name>Q73K89_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972930.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12849">
        <property type="protein sequence ID" value="AAS12849"/>
        <property type="gene ID" value="TDE_2330"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2330"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2199"/>
    <dbReference type="HOGENOM" id="CLU_3049074_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="54" mass="6137" checksum="47BF061A6BA21363" modified="2004-07-05" version="1">MPAIPIKIKAKRKIMHKVIFFMGPVYNGSCTRRPIAASTSTEWIEIGHPLWANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KA3</accession>
    <name>Q73KA3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972916.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680229.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2316"/>
    <dbReference type="EnsemblBacteria" id="AAS12835">
        <property type="protein sequence ID" value="AAS12835"/>
        <property type="gene ID" value="TDE_2316"/>
    </dbReference>
    <dbReference type="GeneID" id="2740281"/>
    <dbReference type="KEGG" id="tde:TDE_2316"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2185"/>
    <dbReference type="eggNOG" id="ENOG503004Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1026504_0_0_12"/>
    <dbReference type="OrthoDB" id="1608599at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284567" evidence="2">
        <location>
            <begin position="27"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="272" mass="30056" checksum="9497B92F428FB2C8" modified="2004-07-05" version="1">MQKLKVKLFGLCFFSLFLFYSPALFSQDFDALTRVQKRVVNIEAAVSEVDIFISAYDGDTIAYKAELSAGTKLSIVEHKKKLRFTEIKPASGKLFIYVPKYFLLESCRILASHSSIKIEGIKAVHFSVSGNFNRAEITGSRLKNSLIALSNGSLTFNSGIVTAADFCLNTSTAKIQIAEEKADCNLFVTKQKCEKFLYEGEAYTDKILALSPSKPKKFISMSASFSDIDLGFSAPLKEPAEKFDKYGVSEFGPKPSPNLVNNEANFLPKTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KH1</accession>
    <name>Q73KH1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA interferase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972847.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680107.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2247"/>
    <dbReference type="EnsemblBacteria" id="AAS12766">
        <property type="protein sequence ID" value="AAS12766"/>
        <property type="gene ID" value="TDE_2247"/>
    </dbReference>
    <dbReference type="GeneID" id="2741352"/>
    <dbReference type="KEGG" id="tde:TDE_2247"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2121"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_1_1_12"/>
    <dbReference type="OMA" id="YPTRIAC"/>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="109" mass="12384" checksum="A0D6EFFF36297CEB" modified="2004-07-05" version="1">MGMVIKQYEVYLINLDPTIGHEIQKTRPCLVISPDVMNNNISTVIIAPMTTKSHAYPTRVSIKFEGKNGWIVLDQIRTVDRVRLVKRLGKIKPAEVLAVKKIIKEMLVD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KN7</accession>
    <name>MNME_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="1">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmE</name>
        <name evidence="1" type="synonym">trmE</name>
        <name type="ordered locus">TDE_2180</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972781.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680027.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KN7"/>
    <dbReference type="SMR" id="Q73KN7"/>
    <dbReference type="STRING" id="243275.TDE_2180"/>
    <dbReference type="PRIDE" id="Q73KN7"/>
    <dbReference type="EnsemblBacteria" id="AAS12700">
        <property type="protein sequence ID" value="AAS12700"/>
        <property type="gene ID" value="TDE_2180"/>
    </dbReference>
    <dbReference type="GeneID" id="2740202"/>
    <dbReference type="KEGG" id="tde:TDE_2180"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2057"/>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_4_1_12"/>
    <dbReference type="OMA" id="CEIQCHG"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000345933" description="tRNA modification GTPase MnmE">
        <location>
            <begin position="1"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="TrmE-type G">
        <location>
            <begin position="225"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
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        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="235"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="254"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
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        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
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        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
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        <location>
            <position position="260"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="279"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <sequence length="472" mass="50927" checksum="A64308D1DB74F3AB" modified="2004-07-05" version="1">MQIGKYSLGDPIAAIATALSPAALGIVRTSGEGAIDLASAIFSKPKKLKEAQGNSILHGWVLDPESKKEVDEVTVCVYREPKSFTGEDSVEFICHGGTAVVLKIYRLLIENGFRAAEGGEFTFRAFANGKADLTRAEAVNEIINSKTDINIELAAGRLSGNLFSGIEEIKHELTAVIAAADVEIEYPEDEETSQGAFSPDLILRIIEPLKDLADSWAAEKIFIQGAKVVLAGKTNAGKSSLFNALLKEDRAIVSDIHGTTRDWLEASLNFNGIPVSLYDTAGIRYTQDSIEAIGVERSLEMSRNADLILYLCDPKDILSAGSLNKDDSEFIKNAKAPVITVITKEDLLDTESKEKIKEILKAEKIAEPIIISSKASNGIKALSEKAYSVLAKNTGSSGFSKTASLGSERQRDAVQKALDVLQTAYQNSLEGFPLDLIVEDLEEALSFLGEITGEVRSDDILDKVFSGFCVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KP5</accession>
    <name>Q73KP5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972773.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2172"/>
    <dbReference type="EnsemblBacteria" id="AAS12692">
        <property type="protein sequence ID" value="AAS12692"/>
        <property type="gene ID" value="TDE_2172"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2172"/>
    <dbReference type="HOGENOM" id="CLU_3334248_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="38" mass="4490" checksum="F9DD5F5AB5EDCBEF" modified="2004-07-05" version="1">MKSILKIIESREIATRKQRTITGKKQELDLYKLAKKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KT4</accession>
    <name>Q73KT4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt transport protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2133</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972734.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2133"/>
    <dbReference type="EnsemblBacteria" id="AAS12653">
        <property type="protein sequence ID" value="AAS12653"/>
        <property type="gene ID" value="TDE_2133"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2133"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2015"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1170240_0_0_12"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="264" mass="30511" checksum="8B0DBE028CD1B552" modified="2004-07-05" version="1">MYIFNRPPLPFSSKSAIKLGLKSGYTIMESLKKAPHITLYILFFFLFYLSSVKHIEVLIVWVFIVISMILIFSPERIKNLKSILGVLPFVIMVLLPFVIRGFYNVPIEQRCFSAKLILRLMCAMMTISFISSKYSYLYLVEGVMKLGLPNFLNQIISLTFRYFFMVRTDLDKTAKAMSARCFDNARTFAKVSTYGEMIGGFFLKAADHGDKVYNAMRARGFTSETKFKPEKIASPFYIGLLVFFALFFIGLTIIERFMEIPWLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L25</accession>
    <name>LOLD_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoprotein-releasing system ATP-binding protein LolD</fullName>
            <ecNumber evidence="1">7.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lolD</name>
        <name type="ordered locus">TDE_2040</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.-" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972643.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668339.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73L25"/>
    <dbReference type="SMR" id="Q73L25"/>
    <dbReference type="STRING" id="243275.TDE_2040"/>
    <dbReference type="EnsemblBacteria" id="AAS12554">
        <property type="protein sequence ID" value="AAS12554"/>
        <property type="gene ID" value="TDE_2040"/>
    </dbReference>
    <dbReference type="GeneID" id="2740634"/>
    <dbReference type="KEGG" id="tde:TDE_2040"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1925"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="LPWLTCF"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51244">
        <property type="entry name" value="LOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000272163" description="Lipoprotein-releasing system ATP-binding protein LolD">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01708"/>
        </source>
    </evidence>
    <sequence length="226" mass="24778" checksum="F855AEFA3456C9CB" modified="2004-07-05" version="1">MSKDIVLISGLTKTFSSASEKLVIFDKLNFSIEEGKKISITGESGSGKSTFLNILGGLESADSGEIIAGSYKVHSLDEKSLTEYRSSFLGLVFQFHYLLKDFTALENVMLPALIAGRSKKEIKEKALSLLEDVKLAERKNHFPSQLSGGERQRVAVARSLINSPSLILADEPTGNLDPANAETVQNLLFSVVDKHKKTLVLVTHDQNIASMTDISYKLYKGNLEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L28</accession>
    <name>Q73L28_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP:guanido phosphotransferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972640.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679813.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73L28"/>
    <dbReference type="STRING" id="243275.TDE_2037"/>
    <dbReference type="EnsemblBacteria" id="AAS12551">
        <property type="protein sequence ID" value="AAS12551"/>
        <property type="gene ID" value="TDE_2037"/>
    </dbReference>
    <dbReference type="GeneID" id="2740631"/>
    <dbReference type="KEGG" id="tde:TDE_2037"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1922"/>
    <dbReference type="eggNOG" id="COG3869">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066591_1_0_12"/>
    <dbReference type="OMA" id="SHFNHIE"/>
    <dbReference type="OrthoDB" id="904915at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07930">
        <property type="entry name" value="bacterial_phosphagen_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023660">
        <property type="entry name" value="Arg_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="PTHR11547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="6">
        <location>
            <begin position="18"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="21"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="168"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="199"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="357" mass="40047" checksum="2B5F1B297020FBF2" modified="2004-07-05" version="1">MISKFDGWYMESGPDTDVVLYSRCDIARNISGFLFPNKINLSDSADVVSLVFSFFCSLGDSSYFKKLKLRAMDPLSIKLLEERGIILPDMPEKIEKAVLVHENGSLYIGLNLEDHINITSFAAGMDPEEVYARASFVELKMREKIKFAEDRDLGFLTSNLMKIGTGLKFSVLCSFPGILYSNCLGSVLELTKQNNLNVAGYYSPNSKSSIGALFLISNAVSAGDNEEIQTEDFISCVNSIIEIEREKRKTFLNENTLKVEDMLRRVLAVAQSAKLMDFKEAADIVFKIKFGLNMGLITGITNEECNSMIFKSQMGHLAFLLLNSHTGLSDRNLNDFSIEEYRARTIQELCSKVRIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L29</accession>
    <name>Q73L29_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972639.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679812.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2036"/>
    <dbReference type="EnsemblBacteria" id="AAS12550">
        <property type="protein sequence ID" value="AAS12550"/>
        <property type="gene ID" value="TDE_2036"/>
    </dbReference>
    <dbReference type="GeneID" id="2740630"/>
    <dbReference type="KEGG" id="tde:TDE_2036"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1921"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_12"/>
    <dbReference type="OMA" id="IREENSP"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="7">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="6">
        <location>
            <begin position="420"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="832" mass="93898" checksum="5AE041FD2A6C5F77" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L55</accession>
    <name>Q73L55_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972613.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679772.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2010"/>
    <dbReference type="EnsemblBacteria" id="AAS12524">
        <property type="protein sequence ID" value="AAS12524"/>
        <property type="gene ID" value="TDE_2010"/>
    </dbReference>
    <dbReference type="GeneID" id="2740357"/>
    <dbReference type="KEGG" id="tde:TDE_2010"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1898"/>
    <dbReference type="eggNOG" id="ENOG502ZA68">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132532_0_0_12"/>
    <dbReference type="OrthoDB" id="1591240at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="171" mass="19388" checksum="381C99C96D72002D" modified="2004-07-05" version="1">MDIIRAILDGIAMAAIFNGSAAALVIANPRYLMDSYPKGIQKAAPEPMSKKEKRANRIFTVIVVGACWLYGVSSTLYGGIHTFKALFCTAYIHWIIVNFGDFFLLDCLLFQKWTKLIVIPGTEDNPIYQTKNWMKVIGIPEHFLLWPFIIVPFFSLVQTGIVMLIQFLFSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-21" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LB4</accession>
    <name>RNZ_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease Z</fullName>
            <shortName evidence="1">RNase Z</shortName>
            <ecNumber evidence="1">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnz</name>
        <name type="ordered locus">TDE_1951</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972554.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679668.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73LB4"/>
    <dbReference type="SMR" id="Q73LB4"/>
    <dbReference type="STRING" id="243275.TDE_1951"/>
    <dbReference type="PRIDE" id="Q73LB4"/>
    <dbReference type="EnsemblBacteria" id="AAS12465">
        <property type="protein sequence ID" value="AAS12465"/>
        <property type="gene ID" value="TDE_1951"/>
    </dbReference>
    <dbReference type="GeneID" id="2740191"/>
    <dbReference type="KEGG" id="tde:TDE_1951"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1843"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_1_12"/>
    <dbReference type="OMA" id="GTQRQMM"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02651">
        <property type="entry name" value="RNase_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000155917" description="Ribonuclease Z">
        <location>
            <begin position="1"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01818"/>
        </source>
    </evidence>
    <sequence length="308" mass="35340" checksum="F3CD30431D51B05B" modified="2004-07-05" version="1">MNLEAFILGCGGMMPLPYRHLTSVLLRREGDLFLFDCGEGTQVALRRLNLRWKRINAIFISHTHADHITGLPGLLMLSSQVDREEPLYIIGPPKVAEYVETSRKVLDMYINYEIIVKEIREPGVVYSTEEFQVRSFWLDHTKPCMGYTFEEFERPGEFNPEAARALNVPCGPLWSKLQGGNEVVSADGKTIRPQDVMGPKRKGRKFSFVTDTKYLPSIAQEVKYSDFFVCEGMFEKGMEKDAAEKKHMTCTQAAQIAKDAEVKKMALIHYSPRYTDNELKVLLDHAREVFPETILSKDRMNIQLEYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LC8</accession>
    <name>Q73LC8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1937"/>
    <dbReference type="EnsemblBacteria" id="AAS12451">
        <property type="protein sequence ID" value="AAS12451"/>
        <property type="gene ID" value="TDE_1937"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1937"/>
    <dbReference type="HOGENOM" id="CLU_3376593_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="34" mass="4211" checksum="ED17932BCBAAE77B" modified="2004-07-05" version="1">MKNDLEHDVNEWLRFVEMDIVVDWCKEQIKTCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LG4</accession>
    <name>Q73LG4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972503.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1900"/>
    <dbReference type="EnsemblBacteria" id="AAS12414">
        <property type="protein sequence ID" value="AAS12414"/>
        <property type="gene ID" value="TDE_1900"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1900"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1799"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_10_4_12"/>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="84" mass="9671" checksum="C889EB623421E563" modified="2004-07-05" version="1">MAKDLQISVITTKRAYDELERDGFIDSVQGKGSFVAYQNPERLKEAGTCIIEEKIAEAIDEAKRLKITQKEFLEIVKLLFDEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LH3</accession>
    <name>Q73LH3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1890"/>
    <dbReference type="EnsemblBacteria" id="AAS12404">
        <property type="protein sequence ID" value="AAS12404"/>
        <property type="gene ID" value="TDE_1890"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1890"/>
    <dbReference type="HOGENOM" id="CLU_3206548_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="45" mass="5392" checksum="06C13EB2256188B3" modified="2004-07-05" version="1">MGNVHPCTFLILEFCLRKTLEVWNHGHPESDFYNLILIQFIEIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LK3</accession>
    <name>Q73LK3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972463.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679550.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1859"/>
    <dbReference type="EnsemblBacteria" id="AAS12374">
        <property type="protein sequence ID" value="AAS12374"/>
        <property type="gene ID" value="TDE_1859"/>
    </dbReference>
    <dbReference type="GeneID" id="2740048"/>
    <dbReference type="KEGG" id="tde:TDE_1859"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1764"/>
    <dbReference type="eggNOG" id="ENOG50334ZE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694322_0_0_12"/>
    <dbReference type="OrthoDB" id="1482860at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012963">
        <property type="entry name" value="DUF1700"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08006">
        <property type="entry name" value="DUF1700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="1">
        <location>
            <begin position="81"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="397" mass="43742" checksum="C97C9605BB6A2BF5" modified="2004-07-05" version="1">MTKDQFLTELNSYLSVLKPEDRKNTIEFYEEYFEDAESEEAAIEELGAPKKLAEEIIDFHKTSYKGENTQVSRQFSPDESISEIILNITAAKVLINASQEEKIEYTTQNIADDDFSAKIENGKLIIKEKPVFFFSKKGFASFLENFNINTSFNAGKREIIINIPKDTRLEKLEFNSQMGSLKIEEVNVEVTEGYTTCGNFSVKSGLHKKIDFNTSAGSINISDIDIETMKLSSSAGAIKFENIKAGNISASTGAGTIDFIRTESSYINANSGAGNITGNELKSDRGKFNTGAGTNKFQKCDFNEVILNTGAGSIIFQGNLHDYAKINSAIGSVDLNLPDNVENYDINIFSKQGRVKLNGENVEGKGDRLNLGSKTSDTNIKISTAFGKIKISTREGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LP1</accession>
    <name>Q73LP1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972425.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957067.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1821"/>
    <dbReference type="EnsemblBacteria" id="AAS12336">
        <property type="protein sequence ID" value="AAS12336"/>
        <property type="gene ID" value="TDE_1821"/>
    </dbReference>
    <dbReference type="GeneID" id="2739251"/>
    <dbReference type="KEGG" id="tde:TDE_1821"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1730"/>
    <dbReference type="eggNOG" id="ENOG5032SRY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1347878_0_0_12"/>
    <dbReference type="OMA" id="FENGYFY"/>
    <dbReference type="OrthoDB" id="1551214at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="190" mass="22612" checksum="520DF7A14AE02562" modified="2004-07-05" version="1">MTIKEFENKYWYMSELKELAKSQKIPFDSKIRKEQLEEMISQFLQTGIVSKKNSSKIKSCNVDILDLNSFVDNFRNTKETWKFINTEMDKRAPGLKIKSGAKYWLNRWIENKLSHGEKITYNDVICEYIRLNKTEGKLPQIPSCKFNNFISDYLANEKNATREDALEAWKKLKDMKIKKDYITWKKNKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LR3</accession>
    <name>Q73LR3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972403.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1799"/>
    <dbReference type="EnsemblBacteria" id="AAS12314">
        <property type="protein sequence ID" value="AAS12314"/>
        <property type="gene ID" value="TDE_1799"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1799"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1711"/>
    <dbReference type="eggNOG" id="ENOG5033JJJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1420886_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="191" mass="21989" checksum="50A5F5C13240F796" modified="2004-07-05" version="1">MIFMDKMTKLDHMSERVKKTGNPKKLNPNTYLGSLESYFELVQNEYRYERDRKQGLETRSGIVLTIVAAMVAIIFDKIPFKDIFSLMMPQLNFIILLKIIAGLLVYFSYIGSVFFAFKTLYTASYAMYNVANISSEKLGNQKNIELGIIITAYRDIIKENRKINEKKAKAFEHAIKLIVICSISVSIYINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LT9</accession>
    <name>Q73LT9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972377.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679524.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12288">
        <property type="protein sequence ID" value="AAS12288"/>
        <property type="gene ID" value="TDE_1773"/>
    </dbReference>
    <dbReference type="GeneID" id="2741217"/>
    <dbReference type="KEGG" id="tde:TDE_1773"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1691"/>
    <dbReference type="eggNOG" id="ENOG5031DTT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1204344_0_0_12"/>
    <dbReference type="OrthoDB" id="2116121at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="230" mass="26721" checksum="5AFF072F5C39A9F5" modified="2004-07-05" version="1">MKRYYIYGFSFIFFLFVSIVLWGCMCNSKNRLEKCYVKKEHTIKSEYSENQRIYSQVYCEDEFDFKKAGSITGSFILPLSTDFDALCFEVLIPNFFWGSVNYDDKWMANIKLPVNVIFEWKDNNDIKQTAKTTVTQNGDETSCGSIGIQYVPLPRNKKIDYTLIFEAGSFCEGYLCKGLEYGEGVQKIDKTADINEHPENYPSKFWKAKFMIVEIKHKGDIIQSQKPADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LV2</accession>
    <name>Q73LV2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972364.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679500.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1760"/>
    <dbReference type="EnsemblBacteria" id="AAS12275">
        <property type="protein sequence ID" value="AAS12275"/>
        <property type="gene ID" value="TDE_1760"/>
    </dbReference>
    <dbReference type="GeneID" id="2740605"/>
    <dbReference type="KEGG" id="tde:TDE_1760"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1682"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_2_2_12"/>
    <dbReference type="OMA" id="GHDWFHI"/>
    <dbReference type="OrthoDB" id="1798994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="27"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="221" mass="25386" checksum="C6EC8DA14D4551E4" modified="2004-07-05" version="1">MTGEEKFKVKIIHDAEKYVESIFREDFSGHDFFHTMRVFRTATYIAEKETADIFIVQLAALLHDVDDRKLSPHTTANKDRAVSFMKSKKISDALCKTIVSIIEEVSFTGKDSNKPSSIEGMCVQDADRLDALGAIGIARAFAYGGSHNRPIYDPSIRPRMGMGKEEYQNHVSTTINHFYEKLFYIKDLMSTDTAKKIAEKRESYMKDFILEFLNEWDLKDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LX0</accession>
    <name>Q73LX0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972346.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957030.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1742"/>
    <dbReference type="EnsemblBacteria" id="AAS12257">
        <property type="protein sequence ID" value="AAS12257"/>
        <property type="gene ID" value="TDE_1742"/>
    </dbReference>
    <dbReference type="GeneID" id="2739200"/>
    <dbReference type="KEGG" id="tde:TDE_1742"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1665"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_12"/>
    <dbReference type="OMA" id="GEGEKMP"/>
    <dbReference type="OrthoDB" id="164380at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
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                <person name="Sodergren E."/>
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                <person name="Weinstock G.M."/>
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        </source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M99</accession>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Eisen J.A."/>
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                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
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                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
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            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MA7</accession>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
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                <person name="Shatsman S."/>
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                <person name="Sodergren E."/>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MB5</accession>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
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                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
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                <person name="Ren Q."/>
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                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
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                <person name="Shatsman S."/>
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                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
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                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
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                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="EnsemblBacteria" id="AAS12111">
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    <dbReference type="PATRIC" id="fig|243275.7.peg.1524"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_4_12"/>
    <dbReference type="OMA" id="IDYGRCS"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="5">
        <location>
            <begin position="37"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="609" mass="66496" checksum="84E7E748C814F9D9" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MF9</accession>
    <name>RECR_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recR</name>
        <name type="ordered locus">TDE_1549</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972155.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956990.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MF9"/>
    <dbReference type="SMR" id="Q73MF9"/>
    <dbReference type="STRING" id="243275.TDE_1549"/>
    <dbReference type="EnsemblBacteria" id="AAS12066">
        <property type="protein sequence ID" value="AAS12066"/>
        <property type="gene ID" value="TDE_1549"/>
    </dbReference>
    <dbReference type="GeneID" id="2740911"/>
    <dbReference type="KEGG" id="tde:TDE_1549"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1485"/>
    <dbReference type="eggNOG" id="COG0353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060739_1_0_12"/>
    <dbReference type="OMA" id="DVMAIEN"/>
    <dbReference type="OrthoDB" id="1661836at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000190415" description="Recombination protein RecR">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="77"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <sequence length="195" mass="21092" checksum="AA0C003B50732741" modified="2004-07-05" version="1">MNAIDAVIDSFSRLPGIGHKSAARIAYHLLKQGPADALRLAEAVSTLHEKIHPCTICGSYTEDEICSICADETRDRATICVVGFPQDVNTISSIPEYRGLFHVLGGLIAPLEGIGPDQLHISELIRRIHEGGITEVILATNPTIEGDTTALYIQKILQDLPVNITRLASGLPVGGDLEYADRLTLARSLNGRIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MJ1</accession>
    <name>Q73MJ1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN_bind domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972123.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679165.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1517"/>
    <dbReference type="DNASU" id="2739723"/>
    <dbReference type="EnsemblBacteria" id="AAS12034">
        <property type="protein sequence ID" value="AAS12034"/>
        <property type="gene ID" value="TDE_1517"/>
    </dbReference>
    <dbReference type="GeneID" id="2739723"/>
    <dbReference type="KEGG" id="tde:TDE_1517"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1456"/>
    <dbReference type="eggNOG" id="COG4939">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119924_0_1_12"/>
    <dbReference type="OMA" id="HKIESAT"/>
    <dbReference type="OrthoDB" id="1544519at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017058">
        <property type="entry name" value="Major_M_immunogen_Tpp15_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036531">
        <property type="entry name" value="Tpp15_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_bind" evidence="1">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="149" mass="16498" checksum="DBA376BFEED63563" modified="2004-07-05" version="1">MKNYKIILTALCFICIFSCSKTETKKSIKYKDGVYKSFANIKDDWGGTAEVEIKIEEGKIVECTFLSYEKNGNLKGPEYGKVDGVIKNMGLYKIAQASVLKAAEYGQKLIETQNIDDVDVIAGASISYKLFKDAVENALQGAMQNAKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MM0</accession>
    <name>Q73MM0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gap</name>
        <name evidence="10" type="ordered locus">TDE_1488</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972094.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668968.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1488"/>
    <dbReference type="EnsemblBacteria" id="AAS12005">
        <property type="protein sequence ID" value="AAS12005"/>
        <property type="gene ID" value="TDE_1488"/>
    </dbReference>
    <dbReference type="GeneID" id="2739889"/>
    <dbReference type="KEGG" id="tde:TDE_1488"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1427"/>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_3_12"/>
    <dbReference type="OMA" id="NCVAPMA"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="PTHR10836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="162"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="223"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS12005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="349" mass="38001" checksum="678AEACBAF473410" modified="2004-07-05" version="1">MKVAINGFGRIGRLVFQALVNQNLLGKDKFDVVAVVDLSTDAKYFAYQLKYDSVQGKMDAKIGTDGDDVLVVNGHKIKCISGKGLTPAQLPWKELGIDVVIESTGIYTNEKAYEHLEAGAKKVIISAPGKSKDPAKPIKTFVMGVNENEYKASEHHVVSNASCTTNCLAPVVHVLLKEGFGIETGLMTTIHAYTATQKTVDGVSLKDWRGGRAAAVNIIPSTTGAAKAVGEVLPTTKGKLTGMSFRVPTPTGSVVDLTIRTEKDTSIEEIDKAIKKASESYLKGVLAYCDEEIVSTDIIHDPHSSIYDSKATLQNNLPGEKRFFKLVSWYDNEWGYSNRVIDLLKFITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MS8</accession>
    <name>Q73MS8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972035.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956968.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1429"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="DNASU" id="2739706"/>
    <dbReference type="EnsemblBacteria" id="AAS11946">
        <property type="protein sequence ID" value="AAS11946"/>
        <property type="gene ID" value="TDE_1429"/>
    </dbReference>
    <dbReference type="GeneID" id="2739706"/>
    <dbReference type="KEGG" id="tde:TDE_1429"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1370"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_1_12"/>
    <dbReference type="OMA" id="WHIYLIN"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="327" mass="38189" checksum="2CE2335C97F9FA7F" modified="2004-07-05" version="1">MKFSIIMPVYNTEKYVEVAILSVLNQSYTDYELICVNDGSTDGSAQILSAFADKIKIIHNYSNKGHHCVRKVGVQNASGDYILFLDSDDWLECDTLKILAKELTNSRPDYIEFGYYMVYANGQKKIWHFSKEDKTKEITDVLLSKANHTLWNKCYSANIIKPIYDSLPDFYAVFSEDYYQMVIIECHIKTRKIINIPLYNYRMTTGISNIPYYDNLEKVKNIDISLNNITQNLFCFFEKENCSDYMQYVRRYLNTIYLEILERTASPEVINIIQNRFGADGMIPLLMQEINALHTKIVKNEQEYRPLHIFAVLLKKPFNGLKRLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MX9</accession>
    <name>Q73MX9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971983.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677935.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1377"/>
    <dbReference type="EnsemblBacteria" id="AAS11894">
        <property type="protein sequence ID" value="AAS11894"/>
        <property type="gene ID" value="TDE_1377"/>
    </dbReference>
    <dbReference type="GeneID" id="2741138"/>
    <dbReference type="KEGG" id="tde:TDE_1377"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1322"/>
    <dbReference type="eggNOG" id="ENOG502Z8NC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1115373_0_0_12"/>
    <dbReference type="OrthoDB" id="1326894at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="249" mass="29885" checksum="FF35CA28586D76FE" modified="2004-07-05" version="1">MEYAYSIRSIDKFKEYNLFLETHKSKIAAYIDFIQNSYSVKDLPEYIVFADFDMATRVHSSISIPAYTNEIRMVITPELNIWKSIYLKQLEVYELKTVENIQSYYSNDINENSILQIIGHELMHQSELFLDDFEDEKKLTEGIWFEEGMVEYISKKFFLTTEEFEKEKQINTSLVKLFEEKYGISSIESFGQETYDENYTSIFYNYWRSFLAIDILVQKFHIVSKVFEHYHNWNKAGRTMPLSKWFQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N01</accession>
    <name>Q73N01_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971961.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678919.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1355"/>
    <dbReference type="EnsemblBacteria" id="AAS11872">
        <property type="protein sequence ID" value="AAS11872"/>
        <property type="gene ID" value="TDE_1355"/>
    </dbReference>
    <dbReference type="GeneID" id="2739456"/>
    <dbReference type="KEGG" id="tde:TDE_1355"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1303"/>
    <dbReference type="HOGENOM" id="CLU_2144757_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="112" mass="12791" checksum="E3A8A096080263AC" modified="2004-07-05" version="1">MPEKIDISEHIADFTACPLDKYTDISNFKSEYGMYTDFINPSSNSGASLALEYDKYGVSQTYLIYKVDDIEKKNICAYFFIGPDMIGFSKENRPDNVPLHIDTIFTAKFSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N29</accession>
    <name>Q73N29_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971933.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678869.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1327"/>
    <dbReference type="EnsemblBacteria" id="AAS11844">
        <property type="protein sequence ID" value="AAS11844"/>
        <property type="gene ID" value="TDE_1327"/>
    </dbReference>
    <dbReference type="GeneID" id="2741061"/>
    <dbReference type="KEGG" id="tde:TDE_1327"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1275"/>
    <dbReference type="eggNOG" id="ENOG502ZGXY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_715595_0_0_12"/>
    <dbReference type="OMA" id="IMECSAG"/>
    <dbReference type="OrthoDB" id="1351906at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="386" mass="43055" checksum="F2B2EA577C2BBCC8" modified="2004-07-05" version="1">MKKVKLFIFLFLIIALNLSAFEGGGMLKTGLGIDLGKNKTNLSHFDSLSLWAKQNLDKEGNYNFAIQSSYLFNLKKPIKPDGKLDLDHIVNLDMLKFSFLVPIGNDSLTIDAGRYNISDITAVILNQNIDGVYIAYNKTNFSTYFNLGYTGLLNSYVNPINAAGITSILKKQTKIYNLAPSFVHMSALFHVPFQSLRHAIDFDLNSFMATENPKTTNNYASISVNGPIVNRLFYLASVSTSILTRDKRKPQTGFFLKGELDYYFEKYDSKLGLKMQLFSGGKMSFKSFTLSTMSKVNFMEPTDLLKISLDGSIKPVKNLFLSTEAAIMAYAATQPKGRSNFAGFEWNVSANYTILQDISISTDLGMFVGKNGKFDAVFKLKGIISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NA5</accession>
    <name>Q73NA5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BatA protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971857.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678753.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1250"/>
    <dbReference type="EnsemblBacteria" id="AAS11768">
        <property type="protein sequence ID" value="AAS11768"/>
        <property type="gene ID" value="TDE_1250"/>
    </dbReference>
    <dbReference type="GeneID" id="2741426"/>
    <dbReference type="KEGG" id="tde:TDE_1250"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1202"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024570_0_0_12"/>
    <dbReference type="OMA" id="RIHMIAI"/>
    <dbReference type="OrthoDB" id="736429at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="91"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="332" mass="36914" checksum="5D567C8D0787C1F5" modified="2004-07-05" version="1">MISFNHPLMLLLILFFFLFLILKKSGLIASPELKLNLVNWKGFFPKKNKLMEFGNLLCYLLWYCGIIFLIIALSEPVIFKNKQVYTDAGSSIMFLLDISPSMAAKDMSGETRIAAAKKIIRKFVAKYPGDSFGLTALSSSAALILPPTIDHKVFLSRLDSLSIGELGDGTAIGMGLAVSSAYMTRTKLNSSYIVLLTDGENNTGEINPKTAAKVLVNKNIGFYVIGIGSSGYTTLEYTDRKTGKTYSGSIFSKFDELELKKIAQYGNGKYASASSPEILENIFNTISKQVPAAQSNFTRIIEENLYVYFLSASIFSFVLVWLLRRIFMRVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ND1</accession>
    <name>Q73ND1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zinc ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">troC</name>
        <name evidence="8" type="ordered locus">TDE_1224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971831.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677722.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1224"/>
    <dbReference type="EnsemblBacteria" id="AAS11742">
        <property type="protein sequence ID" value="AAS11742"/>
        <property type="gene ID" value="TDE_1224"/>
    </dbReference>
    <dbReference type="GeneID" id="2740118"/>
    <dbReference type="KEGG" id="tde:TDE_1224"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1179"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_0_0_12"/>
    <dbReference type="OMA" id="GAWLSYY"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="304" mass="32359" checksum="288B53F354FEA376" modified="2004-07-05" version="1">MNGIITFFADYTLRNVFLGTMLLGIGSGVVGSFAVLRKQSLLGDAVAHAALPGVVIAFLLTGSKMTLPLLLGAGLTGLIGTFFINNIVHNSKVDTDAAQGIVLGVFLGLGFLLLTYVQKLPGAGKSGLDKFIFGQAATITQQDVIIIFIVEAFVLIIIALLWKELKLSTFDPGFSQSIGFSPRIPELILTALIVITIVIGIQSVGVILMSALLLAPAAAARQWTNRLSIMCLLSAFFGAASGMGGAAISSQVSKMPTGPVIVCFLTGFTLISILFSPHRGIIQSKIKKFYIKNKLRKETNMKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NE5</accession>
    <name>Q73NE5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">topA</name>
        <name evidence="12" type="ordered locus">TDE_1208</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971815.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678704.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1208"/>
    <dbReference type="EnsemblBacteria" id="AAS11726">
        <property type="protein sequence ID" value="AAS11726"/>
        <property type="gene ID" value="TDE_1208"/>
    </dbReference>
    <dbReference type="GeneID" id="2740102"/>
    <dbReference type="KEGG" id="tde:TDE_1208"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1163"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_4_3_12"/>
    <dbReference type="OMA" id="PECKYTR"/>
    <dbReference type="OrthoDB" id="223233at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="21"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="182"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS11726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="721" mass="81556" checksum="DD61191D4CEBB33A" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NE8</accession>
    <name>Q73NE8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase/recombinase XerD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">xerD</name>
        <name evidence="6" type="ordered locus">TDE_1205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971812.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1205"/>
    <dbReference type="EnsemblBacteria" id="AAS11723">
        <property type="protein sequence ID" value="AAS11723"/>
        <property type="gene ID" value="TDE_1205"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1205"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1160"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_0_12"/>
    <dbReference type="OMA" id="QAFWYLI"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="74"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="274" mass="31207" checksum="7DC12BF96FEACF60" modified="2004-07-05" version="1">MQLFQEHMSDSLIENATEADCIDFILHRSESGIMAKTIAKDIAALNSFFRFLIIEGVRKDNPSESIERPKREKTLPRVLSPDEVDSLFAAIPLDSPNNIRDRALFELIYSAGLRVSEIVNLKMEDIFYDEDLIKVTGKGNKERIVPFGSAAKYWLKQYILEARTELLKPKHPENTLISGSVFLNNRGAVLTRKGIWKRINELSNFSGIETKVHTLRHSYATHLLAGGADLRSVQCLLGHSDISTTQVYTHIEDKSLQMYHNKFFDTKKLERGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NI0</accession>
    <name>Q73NI0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971780.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1172"/>
    <dbReference type="EnsemblBacteria" id="AAS11661">
        <property type="protein sequence ID" value="AAS11661"/>
        <property type="gene ID" value="TDE_1172"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1172"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1130"/>
    <dbReference type="HOGENOM" id="CLU_2940461_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="64" mass="7519" checksum="403CB3E7E3BDA182" modified="2004-07-05" version="1">MRYKMRYFLAVLLCIVLYFVIFGGLGVILDMPLYNLGAMFYLLNIGYIGLCVFLWKKITKKNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NK1</accession>
    <name>Q73NK1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971759.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956898.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1151"/>
    <dbReference type="EnsemblBacteria" id="AAS11640">
        <property type="protein sequence ID" value="AAS11640"/>
        <property type="gene ID" value="TDE_1151"/>
    </dbReference>
    <dbReference type="GeneID" id="2741483"/>
    <dbReference type="KEGG" id="tde:TDE_1151"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1110"/>
    <dbReference type="HOGENOM" id="CLU_2468110_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="88" mass="10173" checksum="B927F6AA00257590" modified="2004-07-05" version="1">MSKCVIPGYETSSPDEQIEALRKTFKRVFKTEDGKIIFNALLNDLFYFTEAKTEAEKALCEYAKFFLRERLGIIKTLNITNSLIDNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NL4</accession>
    <name>Q73NL4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971746.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956885.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1138"/>
    <dbReference type="EnsemblBacteria" id="AAS11627">
        <property type="protein sequence ID" value="AAS11627"/>
        <property type="gene ID" value="TDE_1138"/>
    </dbReference>
    <dbReference type="GeneID" id="2739997"/>
    <dbReference type="KEGG" id="tde:TDE_1138"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1097"/>
    <dbReference type="HOGENOM" id="CLU_1224297_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="226" mass="25531" checksum="301B22E16E97DBD7" modified="2004-07-05" version="1">MDFPLTEFSRNVIKFGNIAKINTRGYITGDTECLKDENINSSCNYAVWSPAPSEPVFRISFDNEFIMYGLGLTIEMTCNENIPAYGAISYTTVSASNEIHGPFRLGSVFPRDSKGSISSYDEKNVKFKVKELIIGIFGYGRTIDATFTYNFYELLIYERPIKDSGLRIMGNNKIFKPAETAFPSPLSCFHNGKIRHIMLVKPSSHFSSIFRIKTDSGIYMISNLQE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NP4</accession>
    <name>RIMP_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimP</name>
        <name type="ordered locus">TDE_1108</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971716.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670663.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NP4"/>
    <dbReference type="SMR" id="Q73NP4"/>
    <dbReference type="STRING" id="243275.TDE_1108"/>
    <dbReference type="EnsemblBacteria" id="AAS11597">
        <property type="protein sequence ID" value="AAS11597"/>
        <property type="gene ID" value="TDE_1108"/>
    </dbReference>
    <dbReference type="GeneID" id="2740238"/>
    <dbReference type="KEGG" id="tde:TDE_1108"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1067"/>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070525_4_1_12"/>
    <dbReference type="OMA" id="CDLHKMI"/>
    <dbReference type="OrthoDB" id="1595498at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000181947" description="Ribosome maturation factor RimP">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <sequence length="148" mass="16842" checksum="5B51F511482BB00D" modified="2004-07-05" version="1">MEFIQKKDIPYFSECEPLVEGLGFKLVDLNVLHKKDVWQVKAVIKSEKGVGIKDCTSVHRTLQPRIEALIGSQDVTMEVSSPGINRLVKRAVEFYAFVGEEAQIWDNSITDWRHGIIKEVNSEGLVLNSDNQDIQIPYQDIKKARCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NQ9</accession>
    <name>Q73NQ9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971701.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670630.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1093"/>
    <dbReference type="EnsemblBacteria" id="AAS11582">
        <property type="protein sequence ID" value="AAS11582"/>
        <property type="gene ID" value="TDE_1093"/>
    </dbReference>
    <dbReference type="GeneID" id="2740223"/>
    <dbReference type="KEGG" id="tde:TDE_1093"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1052"/>
    <dbReference type="eggNOG" id="COG3330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100589_0_0_12"/>
    <dbReference type="OMA" id="RSWYINI"/>
    <dbReference type="OrthoDB" id="1711249at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032585">
        <property type="entry name" value="DUF4912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16258">
        <property type="entry name" value="DUF4912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="234" mass="27145" checksum="BCA188A0A43B97AE" modified="2004-07-05" version="1">MNLSKSYLQSVSTDELLQIADDYGIFVPKGLCRNLIIEELLEIDEDSNVSDSKLLKVSNDELFLDDEMDGKGNAGLALSYNKTEIHVLLRDPMWAFAFWDFYKPEFLNLVDDPDFDSFFLRVLLLSENNLSESYDYFDIDVAEADRNRYFYLSFEDSVTRVELCSRKIEGEVSVLAKSNLIRLRRKNIPNNLCVLDNDVSSSVYLSGISELKKQHFKNYRQAFRGKEEPKIERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NU3</accession>
    <name>Q73NU3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971667.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1059"/>
    <dbReference type="EnsemblBacteria" id="AAS11548">
        <property type="protein sequence ID" value="AAS11548"/>
        <property type="gene ID" value="TDE_1059"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1059"/>
    <dbReference type="HOGENOM" id="CLU_3367948_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="35" mass="4190" checksum="ACA4138EB93FF1BC" modified="2004-07-05" version="1">MSKADNLTAEDAKDAEIFFIIYYFFQIFSITYLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NX8</accession>
    <name>Q73NX8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971632.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682340.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1024"/>
    <dbReference type="EnsemblBacteria" id="AAS11513">
        <property type="protein sequence ID" value="AAS11513"/>
        <property type="gene ID" value="TDE_1024"/>
    </dbReference>
    <dbReference type="GeneID" id="2741503"/>
    <dbReference type="KEGG" id="tde:TDE_1024"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.986"/>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046680_0_0_12"/>
    <dbReference type="OMA" id="LGMRYSA"/>
    <dbReference type="OrthoDB" id="595291at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006230">
        <property type="entry name" value="MutL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13941">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004729">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01319">
        <property type="entry name" value="glmL_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="459" mass="49860" checksum="EE59D27209393342" modified="2004-07-05" version="1">MNCYLFVDFGSTNTKITLVDIEKEDIIGTAKAYTTVETDVMIGYNNALELLHKKTGTDYTVVKSLACSSAAGGLKIIAIGLVPELTSEAAKRAALGAGAKVIHTYSHNLNKSEAEAIVNSNADIILLAGGTNGGDSRCIIHNAKMLADYGVRVPVVVAGNKSAEDEIIEIFKDRVDFHLAENVMPKINKLNVESARETIRSIFMNNIVHAKGMTHVESNIDNILMPTPAAVLKAAQTLSEGTENEAGLGDLIVLDIGGATTDVHSAAEGDPTQGSVFLYGLPEAFLKRTVEGDLGMRYSLPTVADVQGPHGLRHYLSKEYKYNIEEEVKKRNEHTDFISENAKDLAFDCAVAKVCADVSMGRHVGVLTPVYTGCGASFQQEGKDLTQLRYIIGTGGILVYNPNYKEIMEACKFREDDPFSLKPKNPQFLLDKEYILSAMGLLATEDPDMAIRIMKKHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P23</accession>
    <name>Q73P23_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971586.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0976"/>
    <dbReference type="EnsemblBacteria" id="AAS11467">
        <property type="protein sequence ID" value="AAS11467"/>
        <property type="gene ID" value="TDE_0976"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0976"/>
    <dbReference type="eggNOG" id="ENOG5031DVR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1884863_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="130" mass="14906" checksum="130427182CE98116" modified="2004-07-05" version="1">MLYCTLMTEKHTARSYKHSQQKNAKSCEKHLTRYKVSVKIRSLAASQPRSLAASQPRSLAAEAFPCLNKFTIKHKQIYSHKKPQRSPSLELRSTSQRIIKDSITKTLLNLFASLAYSAVKLKINFDRRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P33</accession>
    <name>Q73P33_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, TatD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971576.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682279.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0966"/>
    <dbReference type="EnsemblBacteria" id="AAS11457">
        <property type="protein sequence ID" value="AAS11457"/>
        <property type="gene ID" value="TDE_0966"/>
    </dbReference>
    <dbReference type="GeneID" id="2740774"/>
    <dbReference type="KEGG" id="tde:TDE_0966"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.930"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1019195_0_0_12"/>
    <dbReference type="OMA" id="RRAMHKI"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="273" mass="31259" checksum="CA84571BE1EA438A" modified="2004-07-05" version="1">MYTDAHVHILDTIEELNSQNIENSILKTFDKDIFFCASANEAGRFEIQEKICRENSEHFILSFGIHPQCPIEDEIPYLEKLLTEKRIAAIGECGFDLFDEHYRSTLEAQKKVWKTQLAFAQKSNLPIVVHCRKGMHLIFDDVKTLKKINAVIFHGWAGSVTEARSFLKKGVNAYFCIGKGLLRGQKAQLETAATLEEDRILTETDAPYMSLKEEKFSLPTDIKKVFSVLAELRAQSEGLLNYDGKTYKNYAEELKDSIFENLKKAYNIRFDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PD0</accession>
    <name>Q73PD0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971479.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682145.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0869"/>
    <dbReference type="EnsemblBacteria" id="AAS11360">
        <property type="protein sequence ID" value="AAS11360"/>
        <property type="gene ID" value="TDE_0869"/>
    </dbReference>
    <dbReference type="GeneID" id="2740916"/>
    <dbReference type="KEGG" id="tde:TDE_0869"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.839"/>
    <dbReference type="eggNOG" id="COG5438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028166_4_0_12"/>
    <dbReference type="OMA" id="SAVWELH"/>
    <dbReference type="OrthoDB" id="1746642at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012507">
        <property type="entry name" value="YibE_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41771">
        <property type="entry name" value="PTHR41771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07907">
        <property type="entry name" value="YibE_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="370" mass="40570" checksum="BD7C5CD410D96E1E" modified="2004-07-05" version="1">MRDKIFAVIIFLITILLFIFMPQIRDSLGQRPMFIQEFAVGVVQDVLEEDLTEDPIVTGRYRGVQKISVKILDGSKKNNVYETYNTLSALHNTRAYKDLKAVFTIRVQDGKESIWLYNQKRDTHIYILVLLFALSLIFLGKRQGFKSLLGLVFTCTVIVSLLVPALFAGFAPIPISILLVSVVTFVSFILVSGFSRKTYAAILGTICGISIAGLISIIVSYTANLSGVNMEGGEQLLNIAPDYNLKLNGLLFISILIASLGAVMDVSMSVSSSMHEILTIDPTIEKKKLFKSGLNVGKDITGTMSNTLILAFAGTSLPLIMMIWGYGMSLRQFINIPKIVIHIVQGLAGSMGIITSVPCTAFFAAVLPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PD4</accession>
    <name>Q73PD4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971475.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672091.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0865"/>
    <dbReference type="EnsemblBacteria" id="AAS11356">
        <property type="protein sequence ID" value="AAS11356"/>
        <property type="gene ID" value="TDE_0865"/>
    </dbReference>
    <dbReference type="GeneID" id="2741376"/>
    <dbReference type="KEGG" id="tde:TDE_0865"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.834"/>
    <dbReference type="eggNOG" id="ENOG5033EE8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144077_0_0_12"/>
    <dbReference type="OMA" id="FEDEMRP"/>
    <dbReference type="OrthoDB" id="1950962at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032422">
        <property type="term" value="F:purine-rich negative regulatory element binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021694">
        <property type="entry name" value="DUF3276"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006628">
        <property type="entry name" value="PUR-bd_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11680">
        <property type="entry name" value="DUF3276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00712">
        <property type="entry name" value="PUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="130" mass="14708" checksum="D83570335DDB3272" modified="2004-07-05" version="1">MGIRGELFTTQVSAENRTYFFNVKENTKGDVFLQVVESKVSEGLGFDRHAVVVFEDEMRPFLQGLDKCIEFIEKNRKEKAKAKAKKVSDAKKAAEKSDKPAKPRASKGQSAEKKDGEKSRVKKVIKKKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PD7</accession>
    <name>Q73PD7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971472.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682134.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0862"/>
    <dbReference type="EnsemblBacteria" id="AAS11353">
        <property type="protein sequence ID" value="AAS11353"/>
        <property type="gene ID" value="TDE_0862"/>
    </dbReference>
    <dbReference type="GeneID" id="2741373"/>
    <dbReference type="KEGG" id="tde:TDE_0862"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.831"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057504_0_2_12"/>
    <dbReference type="OMA" id="KANCEVD"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="284" mass="33249" checksum="C26D22DF3E89BB75" modified="2004-07-05" version="1">MEKLFKITLRNDYAFKRVFGVEENKDVLQDLLECILDIPPETIAGLELLDKEFQKELLTEKLGILDIKLRLNDGTFVDIEIQNNWHFDFPERTLYYWSKMYNENIKQGQDYTKLPKCITINLIGKGFDKNKRLHNKYLVLEQDTKEPLVSKLEIHILSLEKARLLKDGQCKDNKAKHLLHWLKFIETDNKEVRSVLAQESTMMAKANTAISVMEMSPRDKWLYDSRMKYEHDRASCISEGYRQGIDKGAHQKALETANLMKKANCEVDFIIQMTGLSKEEIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PE0</accession>
    <name>Q73PE0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FMN_dh domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971469.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682131.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0859"/>
    <dbReference type="EnsemblBacteria" id="AAS11350">
        <property type="protein sequence ID" value="AAS11350"/>
        <property type="gene ID" value="TDE_0859"/>
    </dbReference>
    <dbReference type="GeneID" id="2741370"/>
    <dbReference type="KEGG" id="tde:TDE_0859"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.828"/>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020639_6_0_12"/>
    <dbReference type="OMA" id="IPFIKPW"/>
    <dbReference type="OrthoDB" id="1186741at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_dh" evidence="2">
        <location>
            <begin position="161"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="308" mass="34160" checksum="890329A76C561021" modified="2004-07-05" version="1">MSVNKKYKCRLCKECNGKACIGELPGMGGVFESANFILNCAEWKNYYTSDFYPLPRLRLAPMTGAVENVGYEDERQFYFDLIRASVKAGLALSIGDGYPDLKLFSGIEALRDVKKKGAVFLKPYPQMKLFERIEASMESAEIIGVDTDAYNIVTMRNLVHLEKKSAKDLAALKKYAKLPFAVKGIFTSYDIEVVKELKPDIAIISNHGGRIETDRGSVAAFVNSHLKEIKKYSGEVWADGGLRKREDFMAASSLGIEEVLIGRPCITALLRDRENGIKNFIDSILGKDLTKEACGSLGSGPLRSFEKP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PM8</accession>
    <name>RS19_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsS</name>
        <name type="ordered locus">TDE_0771</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971381.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669999.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PM8"/>
    <dbReference type="SMR" id="Q73PM8"/>
    <dbReference type="STRING" id="243275.TDE_0771"/>
    <dbReference type="EnsemblBacteria" id="AAS11262">
        <property type="protein sequence ID" value="AAS11262"/>
        <property type="gene ID" value="TDE_0771"/>
    </dbReference>
    <dbReference type="GeneID" id="2740311"/>
    <dbReference type="KEGG" id="tde:TDE_0771"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.744"/>
    <dbReference type="eggNOG" id="COG0185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_0_1_12"/>
    <dbReference type="OMA" id="FPEMVGH"/>
    <dbReference type="OrthoDB" id="1893906at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000129931" description="30S ribosomal protein S19">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <sequence length="92" mass="10361" checksum="226D50CE18E6C527" modified="2004-07-05" version="1">MSRSVKKGPFIAKSLFKNVNEMNRSGKKKPIKTYSRCSTIIPEMVGNTISVHNGKTWIPVYITENLVGHKLGEFAPTRTFRKHANSDKKVGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PM9</accession>
    <name>RL2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplB</name>
        <name type="ordered locus">TDE_0770</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971380.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669998.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PM9"/>
    <dbReference type="SMR" id="Q73PM9"/>
    <dbReference type="STRING" id="243275.TDE_0770"/>
    <dbReference type="EnsemblBacteria" id="AAS11261">
        <property type="protein sequence ID" value="AAS11261"/>
        <property type="gene ID" value="TDE_0770"/>
    </dbReference>
    <dbReference type="GeneID" id="2740310"/>
    <dbReference type="KEGG" id="tde:TDE_0770"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.743"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_12"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="OrthoDB" id="961486at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000237263" description="50S ribosomal protein L2">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="276" mass="30304" checksum="79A7AD2B0BE20EAC" modified="2004-07-05" version="1">MALKEYKPMTPGLRGRIDLRKDEITAQKPEKSLTTGKKNRAGRDSRGRISVRGQGGGHKQKYRQIDFKRNKYGIPGTVRTIEYDPNRSANIALIFYADGEKRYIIAPKGLKIGQKIMSGEMATLDVANALPLEAIPVGFTVHNIELTIGRGGQMARSAGAGALVAAKEGEYVTIRLPSGETRLVNKKCYATIGEVGNEDHMNTSLGKAGRSRWLGIRPTVRGMAMNPIDHPLGGGEGRGKGRHPVTPWGQPCKGYKTRKKRNPSDSFIVSRRKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PS7</accession>
    <name>Q73PS7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bacteriocin ABC transporter, ATP-binding/permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_0719</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971331.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681955.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0719"/>
    <dbReference type="MEROPS" id="C39.001"/>
    <dbReference type="EnsemblBacteria" id="AAS11212">
        <property type="protein sequence ID" value="AAS11212"/>
        <property type="gene ID" value="TDE_0719"/>
    </dbReference>
    <dbReference type="GeneID" id="2740626"/>
    <dbReference type="KEGG" id="tde:TDE_0719"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.695"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OMA" id="IYYWPLA"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043214">
        <property type="term" value="F:ABC-type bacteriocin transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005897">
        <property type="entry name" value="Pept_C39_ABC_bacteriocin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01193">
        <property type="entry name" value="bacteriocin_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="10">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="164"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="479"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="512"/>
            <end position="519"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="717" mass="80280" checksum="14CD6CBE558D1BFE" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PV0</accession>
    <name>Q73PV0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971308.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681920.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0696"/>
    <dbReference type="EnsemblBacteria" id="AAS11189">
        <property type="protein sequence ID" value="AAS11189"/>
        <property type="gene ID" value="TDE_0696"/>
    </dbReference>
    <dbReference type="GeneID" id="2739818"/>
    <dbReference type="KEGG" id="tde:TDE_0696"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.675"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051632_1_1_12"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="388" mass="44828" checksum="C4EAC42BB4450AAE" modified="2004-07-05" version="1">MIVYKNFLRLICTKVISTIIYVVIFLFISFMTLKSQNSQVSEFAETPLTVNIIDRDGSELSKHLISYLKSKHDVIIIDEKGKTDEEILRELKKDISLQRIHAGIIINKNMEENVMSGKKALITFKDDRKKSGFYMDLQLNTYLTFASSVKKTQGYFDFQRIEKALQVNTKVNKISFQKNTSVNIWFKIFFNFLGWIVFSVVLNSVGWAMFELNNERLKMRNNVSPVSTFRFVCENFLAQLTIVIFILSILIGFAIITNITRLENIPLLLYTFNALMYTAVILSLTFMLNSFLKKGSVMGIVGTVLPLSMAFISGIFVEQELLPDFIVNISRLFPTYYYVMANEFTQVNLSIDWKNIGMLFLFLFLYFTVGTYFSKLGRSQSKIEFAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="139" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PX5</accession>
    <name>Q73PX5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 13" type="primary">lon</name>
        <name evidence="13" type="ordered locus">TDE_0670</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971283.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681876.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0670"/>
    <dbReference type="EnsemblBacteria" id="AAS11164">
        <property type="protein sequence ID" value="AAS11164"/>
        <property type="gene ID" value="TDE_0670"/>
    </dbReference>
    <dbReference type="GeneID" id="2739663"/>
    <dbReference type="KEGG" id="tde:TDE_0670"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.651"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_12"/>
    <dbReference type="OMA" id="GAWQVVD"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="PTHR43718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="602"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="690"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="733"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS11164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="791" mass="89159" checksum="DA803A9FD2CADAEA" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q36</accession>
    <name>Q73Q36_TREDE</name>
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        <submittedName>
            <fullName evidence="2">DNA-binding protein, putative</fullName>
        </submittedName>
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        <name evidence="2" type="ordered locus">TDE_0608</name>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
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            <taxon>Spirochaetales</taxon>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS11103.1"/>
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    <dbReference type="EnsemblBacteria" id="AAS11103">
        <property type="protein sequence ID" value="AAS11103"/>
        <property type="gene ID" value="TDE_0608"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.588"/>
    <dbReference type="HOGENOM" id="CLU_2995336_0_0_12"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="57" mass="6579" checksum="1F097FE94B7FA654" modified="2004-07-05" version="1">METLKTNPKITQQEISKSLNISLRTVKRILARLQEENIVKREGSSRAGTWLVVDEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q62</accession>
    <name>Q73Q62_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AAS11077">
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        <property type="gene ID" value="TDE_0582"/>
    </dbReference>
    <dbReference type="GeneID" id="2741018"/>
    <dbReference type="KEGG" id="tde:TDE_0582"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.563"/>
    <dbReference type="eggNOG" id="COG0714">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_12"/>
    <dbReference type="OMA" id="YPIPEPF"/>
    <dbReference type="OrthoDB" id="895310at2"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="34"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="322" mass="35774" checksum="7101535D669BD331" modified="2004-07-05" version="1">MNTKNIIDELIRNIGLVIKGKDEVIRLFVAAFLTGGNVLIDDVPGVGKTTMVKALAKLIKKDYGDPAEFKRIQCTPDLLPYDITGVDVFNAQTQSFEFIKGPVFCDIFLADELNRTPPKVQAALLEVMEEKQVTVGKQTYKLPETFFTAATQNPVETLGTYPLPPAQLDRFMVSISIGYPDDESALEILDGNPGVSALSKLYPIITTGNIITSREEQERVYCHKALQKAIIDICNKTREHSDIELGASPRASLQFLHLAKTMALSNGRNWVEDTDIEIIAPYVLAHKCIFKNRKANAKESIAEITKSVLIKMDKETDWSKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q66</accession>
    <name>Q73Q66_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS11073">
        <property type="protein sequence ID" value="AAS11073"/>
        <property type="gene ID" value="TDE_0578"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0578"/>
    <dbReference type="HOGENOM" id="CLU_3376598_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="34" mass="4174" checksum="5729198A980F24AA" modified="2004-07-05" version="1">MLSRAKEGKQYTKKRSGKWRVYRQKTWKNLTKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QB9</accession>
    <name>Q73QB9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971138.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681659.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0524"/>
    <dbReference type="EnsemblBacteria" id="AAS11019">
        <property type="protein sequence ID" value="AAS11019"/>
        <property type="gene ID" value="TDE_0524"/>
    </dbReference>
    <dbReference type="GeneID" id="2739261"/>
    <dbReference type="KEGG" id="tde:TDE_0524"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.510"/>
    <dbReference type="eggNOG" id="ENOG5032QZI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134968_1_0_12"/>
    <dbReference type="OMA" id="TIEHARF"/>
    <dbReference type="OrthoDB" id="1411810at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018546">
        <property type="entry name" value="DUF2004"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09406">
        <property type="entry name" value="DUF2004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="151" mass="17501" checksum="97212AA7BB2AB20A" modified="2004-07-05" version="1">MKKMEHQYFGQLNLATTDDVEVIWEKEIQGIDTCLWLGKNVELSTGILDLYAQFLENIDDKIKEARKALIAYLNDDSYYIDFHIEECGLEDLPTDIIEFVSKMKITNVSLWIDSEKPHIAMDFMIAPDESDEILCVKFGEDVKIISIDWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QF6</accession>
    <name>Q73QF6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971101.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681592.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0487"/>
    <dbReference type="EnsemblBacteria" id="AAS10982">
        <property type="protein sequence ID" value="AAS10982"/>
        <property type="gene ID" value="TDE_0487"/>
    </dbReference>
    <dbReference type="GeneID" id="2741392"/>
    <dbReference type="KEGG" id="tde:TDE_0487"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.472"/>
    <dbReference type="eggNOG" id="COG4586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="VEGPRQW"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="261" mass="29434" checksum="0C99A997643A8FEB" modified="2004-07-05" version="1">MIKVQNICKTYKVAKRNKGLKEAAKALFKRDYEYIKALNDVSFTISEGETVGYIGPNGAGKSSTIKVLCGILTPDSGTCEIAGLVPWKKRVEYVKNIGVVFGQRTQLWWDIPVIDSFELLKDIYSVPQNLFQNNLEELINLLELKEIVKTPARQLSLGQRMKCEIAASLLHSPKILFLDEPTIGLDALSKLTVRKFISELNKKNKTTIILTTHDMQDIEAITERIILIDKGRILLDGTLKDIKKDSLSLDESLAEFYKENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QH2</accession>
    <name>Q73QH2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BNR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971085.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681567.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73QH2"/>
    <dbReference type="STRING" id="243275.TDE_0471"/>
    <dbReference type="CAZy" id="GH33">
        <property type="family name" value="Glycoside Hydrolase Family 33"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10966">
        <property type="protein sequence ID" value="AAS10966"/>
        <property type="gene ID" value="TDE_0471"/>
    </dbReference>
    <dbReference type="GeneID" id="2740518"/>
    <dbReference type="KEGG" id="tde:TDE_0471"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.456"/>
    <dbReference type="eggNOG" id="COG2755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025267_0_0_12"/>
    <dbReference type="OMA" id="WSPTEFI"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="BRENDA" id="3.2.1.18">
        <property type="organism ID" value="6426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013378">
        <property type="entry name" value="Listeria/Bacterioides_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042229">
        <property type="entry name" value="Listeria/Bacterioides_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09479">
        <property type="entry name" value="Flg_new"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285895" evidence="1">
        <location>
            <begin position="25"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="543" mass="59846" checksum="F780495A0ADB1C36" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QI3</accession>
    <name>Q73QI3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971074.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676815.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0460"/>
    <dbReference type="EnsemblBacteria" id="AAS10955">
        <property type="protein sequence ID" value="AAS10955"/>
        <property type="gene ID" value="TDE_0460"/>
    </dbReference>
    <dbReference type="GeneID" id="2740757"/>
    <dbReference type="KEGG" id="tde:TDE_0460"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.446"/>
    <dbReference type="eggNOG" id="ENOG5033080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101810_0_0_12"/>
    <dbReference type="OrthoDB" id="1508127at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CorC_HlyC" evidence="2">
        <location>
            <begin position="137"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="222" mass="25103" checksum="034BC8F8CF4A84F4" modified="2004-07-05" version="1">MQKIKAFFHQQNLRRRAARLAGRIEIVLSFAMLIGILILSIEIFFDLKEMIFAFIYDKKVPSFSEFLSLIFSLVIGLEFVNMLIKHTPGSALEVVLYTIARKIIADHGSMLDALLGVVAIAALFAVKKYLNEGGEYGAGNECDYIVNGGTSIHEINHRLDSDFDEAYGNTVAGYLFNYLKQQGRSPHLGLEADIGEYKFIIHEMDNDLIRYIKILPINEHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QK3</accession>
    <name>Q73QK3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971054.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10935">
        <property type="protein sequence ID" value="AAS10935"/>
        <property type="gene ID" value="TDE_0440"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0440"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.427"/>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_8_12"/>
    <dbReference type="OMA" id="CHALNIN"/>
    <dbReference type="OrthoDB" id="1669337at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="91" mass="10651" checksum="86F1221B49429272" modified="2004-07-05" version="1">MFLREQQNLVINRLRKEREKAGLSQLELALRADISQNMINYIETGKRTPSLDTLLKICHALNINPAVLFSDTEEEKEKAKKQVLDIIQRWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QS6</accession>
    <name>Q73QS6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970981.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681377.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0367"/>
    <dbReference type="EnsemblBacteria" id="AAS10862">
        <property type="protein sequence ID" value="AAS10862"/>
        <property type="gene ID" value="TDE_0367"/>
    </dbReference>
    <dbReference type="GeneID" id="2740119"/>
    <dbReference type="KEGG" id="tde:TDE_0367"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.357"/>
    <dbReference type="eggNOG" id="COG3943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048266_0_0_12"/>
    <dbReference type="OMA" id="MEDETVW"/>
    <dbReference type="OrthoDB" id="1838027at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011204">
        <property type="entry name" value="Virulence_RhuM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13310">
        <property type="entry name" value="Virulence_RhuM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015268">
        <property type="entry name" value="Virulence_RhuM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="339" mass="38665" checksum="FA6B23D1108B3FDE" modified="2004-07-05" version="1">MNAKHGEVIIYTSDDGVTKINVNLHDETVWLSLDQMAELFQRDKSTISRHIKNIFTEGELQEHSVVAKFATTAADGKIYQVDYYNLDVIISVGYRVKSLAGTRFRIWANSILKEYIKKGFAIDDERLKGTGGGSYWKELLDRIRDIRSSEKILYRQVLDLYATSVDYDPKSEESLAFFKIVQNKLHYAAHGHTAAEVIYDRADAEKPFMGLKAFSGELPVRKDIGIAKNYLDEEELKILNNLVSGYFDIAEINAIEHRPMYMQDYIEQLDAVLTSGKRKLLEGAGRVSHEQAVKKAEKEYRKYQTESLTSVEKAYLDSLKKIEKKAKKASKSKKESPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QU3</accession>
    <name>Q73QU3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multidrug export protein MepA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970964.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681330.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0350"/>
    <dbReference type="EnsemblBacteria" id="AAS10845">
        <property type="protein sequence ID" value="AAS10845"/>
        <property type="gene ID" value="TDE_0350"/>
    </dbReference>
    <dbReference type="GeneID" id="2741246"/>
    <dbReference type="KEGG" id="tde:TDE_0350"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.339"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_0_1_12"/>
    <dbReference type="OMA" id="SKAIMHM"/>
    <dbReference type="OrthoDB" id="216729at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13143">
        <property type="entry name" value="MATE_MepA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045070">
        <property type="entry name" value="MATE_MepA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="455" mass="49894" checksum="2C5E8F561D8E0F52" modified="2004-07-05" version="1">MDSKELRRFNILTKPIFPLLVKTSIPTIIGMLISVIYNLTDTFFVGRLNNRAMIAAIGIVFSFVSIIQAIGFWFGYGSGNAMSKKIGEQDYAEAETISSVGIVFAIIIGILIAIGASIFILPLSKFIGGSASQDVLTFTVQYLRIIIISIPFSLYALTVYNQLRLCGNVRDGMVGLLSGMLSNMVLDPVLMFIFKQGFIGAGYATLIGQIIGCIVLTLLAKRHESISFNLKKVQYSKERMYHILAGGMPNFSRQAITSAALVLLNVKAAQYGESMIAALTVSSRVAALAYMIMIGWGQGFQPICAMNYGAKQYSRVKKAFITTVLIGTIFLTAASIILFLFAEQCIGVMSKDDEVIFAGIKILRMQCFSLPLLSFFAVSSMFMQNIGHYFSSLLISISRQGFFYLPLLYILPALYGKTGIYLLQPFSDVLSFLFAVAVVYRWYSSGAFSSALNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QW7</accession>
    <name>Q73QW7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">recQ</name>
        <name evidence="12" type="ordered locus">TDE_0326</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970940.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681287.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0326"/>
    <dbReference type="EnsemblBacteria" id="AAS10821">
        <property type="protein sequence ID" value="AAS10821"/>
        <property type="gene ID" value="TDE_0326"/>
    </dbReference>
    <dbReference type="GeneID" id="2739333"/>
    <dbReference type="KEGG" id="tde:TDE_0326"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.315"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_14_3_12"/>
    <dbReference type="OMA" id="HHDIPKS"/>
    <dbReference type="OrthoDB" id="54580at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006293">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01389">
        <property type="entry name" value="recQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="38"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="227"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="9">
        <location>
            <begin position="549"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS10821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="626" mass="70629" checksum="35E9672684A4462F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R47</accession>
    <name>Q73R47_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0244</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970860.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681161.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0244"/>
    <dbReference type="EnsemblBacteria" id="AAS10741">
        <property type="protein sequence ID" value="AAS10741"/>
        <property type="gene ID" value="TDE_0244"/>
    </dbReference>
    <dbReference type="GeneID" id="2741443"/>
    <dbReference type="KEGG" id="tde:TDE_0244"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.239"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_12"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="331"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="364"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="574" mass="63967" checksum="604E71533FEB6053" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R63</accession>
    <name>Q73R63_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970844.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681133.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0228"/>
    <dbReference type="REBASE" id="6312">
        <property type="entry name" value="TdeII"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10725">
        <property type="protein sequence ID" value="AAS10725"/>
        <property type="gene ID" value="TDE_0228"/>
    </dbReference>
    <dbReference type="GeneID" id="2739080"/>
    <dbReference type="KEGG" id="tde:TDE_0228"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.221"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_841828_0_0_12"/>
    <dbReference type="OrthoDB" id="24005at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="330" mass="38330" checksum="70E2F6F219F4EE9D" modified="2004-07-05" version="1">MSRREVKNQTNISRIEGIKPNDAYVAYVCVQCNNLNMINIGQKLLDPREAYETQEWKCERCGFLHSKNNSLSYSNWPEESKKKGSIPVQRFWQAFFRVYTENKEAYWKQCNCCGKILPFSAFSKHIGFGPLERQMECRACKGVINAFLNPERTEDQLRESNVRRRVADLFVKKENKSKDDGFIKDLFKRFGSKCFKTKKYLNIHDRNSWAIDHILPSKYLYPLTKENAALLSVEANSNKRDRWPSEFYTNNELIELATITGADLQLLSNKTPIINPNLTDEDINAGIENYLSVRENSNLEKRVAEIKKIIIDYQLTDKLSKSNKNLLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R78</accession>
    <name>Q73R78_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970829.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681112.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0213"/>
    <dbReference type="EnsemblBacteria" id="AAS10710">
        <property type="protein sequence ID" value="AAS10710"/>
        <property type="gene ID" value="TDE_0213"/>
    </dbReference>
    <dbReference type="GeneID" id="2739370"/>
    <dbReference type="KEGG" id="tde:TDE_0213"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.207"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064073_0_0_12"/>
    <dbReference type="OMA" id="WNAWFLL"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="380" mass="43758" checksum="A16F028488C386D6" modified="2004-07-05" version="1">MQNPIDSLLYVKISAEQAGKIFENLESSIPLPIQLSEPGQKEDFKAENIKPEMILAGMLTVFAYDRENPHITYYRKIFNLLRPDIRKEMTEAAIIKIKNNDFDMAEEILLSLEGLNPDDGITKLNLALLMEERSQFCEMRELFEDALSFNKRAEELYSELILFEPPLPGVFFNAAYFFIKQKNYIKAKSLLKTYLEIENDSSETAEFRKAKASELLKTISEQALDDELFQKAYKCIDLGEEEKAAESIKLFLRKNPKVWNAWFLLGWALRRMGRWEDARSSFLKTIELLENSEISDKEPLCDVYNELAICLMELELFDEAEKHLINALSLDSENIKIISNLGTLALKQGKQEEAEAFFRTVLEINPDDKIALNVLGKPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R86</accession>
    <name>Q73R86_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylate/guanylate cyclase catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970821.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681105.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0205"/>
    <dbReference type="EnsemblBacteria" id="AAS10702">
        <property type="protein sequence ID" value="AAS10702"/>
        <property type="gene ID" value="TDE_0205"/>
    </dbReference>
    <dbReference type="GeneID" id="2739811"/>
    <dbReference type="KEGG" id="tde:TDE_0205"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.199"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_782891_0_0_12"/>
    <dbReference type="OMA" id="KELHEHY"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DUF5939"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF55073"/>
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        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="181"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="354" mass="39772" checksum="C7F9692632EE498F" modified="2004-07-05" version="1">MNLNLQYNQNQEEADKIAASLSALQEEKLFHIDVYGLAEELSLNRETALNIFIQGVYDGFFIIDWIYHCPTCGSVAHETLSIHEAVSENYCPACQKNFNNTLDDNIEVFFSIHPNILPLDSSLKENYLAKIETDVNEGNYLTWKTPNSIKGIDLIQNNLYRDLMGSDVLIPGQSLQVMKAAILFTDIKGSTLMYSELGDAKAFALVRDHFIILFDVIKKFGGVPVKTIGDAIMGVFMNSKKAVDASIEAQKELHEHYKNNPEIEKIEVKIGIHAGPALVVTLNNRLDYFGTSVNMAARIQNAAQPNEVVISEELFNNNEIQKSIAAITNKVQRQRITFKGIKEESTIYHIKVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RC9</accession>
    <name>Q73RC9_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970777.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0161"/>
    <dbReference type="EnsemblBacteria" id="AAS10658">
        <property type="protein sequence ID" value="AAS10658"/>
        <property type="gene ID" value="TDE_0161"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0161"/>
    <dbReference type="HOGENOM" id="CLU_3376596_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="34" mass="4308" checksum="A579665AF1D530AE" modified="2004-07-05" version="1">MFNYKKISKIIRLKRGLEKISFFGYLYRDMFNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RE5</accession>
    <name>Q73RE5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiamine ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0144</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970761.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681013.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0144"/>
    <dbReference type="TCDB" id="3.A.1.19.2">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10642">
        <property type="protein sequence ID" value="AAS10642"/>
        <property type="gene ID" value="TDE_0144"/>
    </dbReference>
    <dbReference type="GeneID" id="2739299"/>
    <dbReference type="KEGG" id="tde:TDE_0144"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.142"/>
    <dbReference type="eggNOG" id="COG1178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_5_2_12"/>
    <dbReference type="OMA" id="PLYLFQL"/>
    <dbReference type="OrthoDB" id="1783638at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="82"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="375"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="560" mass="63023" checksum="7F802E954181B6A6" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RF5</accession>
    <name>Q73RF5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase, FAD-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970751.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0134"/>
    <dbReference type="EnsemblBacteria" id="AAS10632">
        <property type="protein sequence ID" value="AAS10632"/>
        <property type="gene ID" value="TDE_0134"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0134"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.134"/>
    <dbReference type="eggNOG" id="COG0579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_3_1_12"/>
    <dbReference type="OMA" id="MGRCQGF"/>
    <dbReference type="OrthoDB" id="1371190at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="17"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="421"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="508" mass="55866" checksum="F0C060E48A176224" modified="2004-07-05" version="1">MRLPKIQDSLLEDRNFDAVIIGGGVIGCSIARELSRYDLKIALFEKESDVAMQASGHNDGMIHPGFADNPKKIKGKLNTRGNRMYTKVSEELGFEINRCGSFFLFHHPILKLLVPIMKKRCRLNGVDGDYGYRSREAVKKTDPFMTDKNYGGFWLPSAGVASPMKVTICYAENACENGVEFFSNTALIGIKKEGNTITELITNRGTCRTKLLINAAGVWADKVAGLAGDRFFSIHARKGTDAILDKKLNGLQKTSSAMPNLLRLSKGHSKGGGIMPCVEGNLLIGPNAVEVMDREDFSTKPEALEEIKKHLTLNSKVSPSDIITYYSGTRACTWEEDFIVEASERVDNLVHAAGIQSPGFASAPAIAEDIVKISVSILKKKIDVSLKENFSPVRKAMKPVSEMETNERQALIEKNPQYGKIICRCEQVSEGEIRDSVNNPLNVFTLDAVKRRIRAGAGRCHGGFCTPHVLKIIAEEKGIPIEKLTKKGEGSEIVQPIEKFEAFSGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RH5</accession>
    <name>Q73RH5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tpl protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970730.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680971.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0113"/>
    <dbReference type="EnsemblBacteria" id="AAS10611">
        <property type="protein sequence ID" value="AAS10611"/>
        <property type="gene ID" value="TDE_0113"/>
    </dbReference>
    <dbReference type="GeneID" id="2741728"/>
    <dbReference type="KEGG" id="tde:TDE_0113"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.113"/>
    <dbReference type="eggNOG" id="COG1774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033149_2_0_12"/>
    <dbReference type="OMA" id="CCHAVSD"/>
    <dbReference type="OrthoDB" id="1523756at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="93"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="304" mass="34732" checksum="6863EC235F0C144A" modified="2004-07-05" version="1">MDYDINENIEDIESLEDKDQRPVKMSSNPNDFPQPLYELNLDYSKESFYATADEHQEFKTGDFVLVPTRYGNDAARFGGPVKAPINANPDEVVKIIRKINAEEEIILEENNKKEKEAAKIFKEKVALNNLEMKFIGCHFLLDEPKVLFFFSADTRIDFRKLVKDLVSVFKIRVELRQIGVRDESRIIGGLGCCGRPYCCHNVTDKLKPVSIKMAKEQNLSLNSSKISGQCGRLLCCLSYEYDWYAEARRLMPPEGARFPYDGTTFKITEVNLLTQMVSLLGEDGRILSLPSKRVVNIGGKWQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RI3</accession>
    <name>Q73RI3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenosylhomocysteine nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.9" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970722.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680958.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0105"/>
    <dbReference type="EnsemblBacteria" id="AAS10603">
        <property type="protein sequence ID" value="AAS10603"/>
        <property type="gene ID" value="TDE_0105"/>
    </dbReference>
    <dbReference type="GeneID" id="2741720"/>
    <dbReference type="KEGG" id="tde:TDE_0105"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.105"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031248_2_0_12"/>
    <dbReference type="OMA" id="DQFVHSK"/>
    <dbReference type="OrthoDB" id="1860206at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00871"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008782">
        <property type="term" value="F:adenosylhomocysteine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008930">
        <property type="term" value="F:methylthioadenosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010049">
        <property type="entry name" value="MTA_SAH_Nsdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01704">
        <property type="entry name" value="MTA/SAH-Nsdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="6">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS10603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="240" mass="25969" checksum="E00559716538D59B" modified="2004-07-05" version="1">MKIGIFGAEEQEVKLLKKHLVGEIRKIAGLSFFTGTIMGKDVVLVCSGIGKVNAALCCQILISEFKVDAVINTGAAGGLLEGINVFDMVVSTDAVQHDVDATAFGHPIGQVPMTKSPFWPADKKLKTLALKAFKAMQKESDDEHIKNLKLIEGRIASGDTFVSDKKLRERIIKEFNPACVEMEGAAAAQVCCINKIHFLILRSISDTAGKDKAAKISYEVFSAQAAKDSSLLVLQMLKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>F7IVK6</accession>
    <name>F7IVK6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chemotaxis protein CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cheY</name>
        <name evidence="4" type="ordered locus">TDE_1494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972100.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668975.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="F7IVK6"/>
    <dbReference type="STRING" id="243275.TDE_1494"/>
    <dbReference type="EnsemblBacteria" id="AAS12011">
        <property type="protein sequence ID" value="AAS12011"/>
        <property type="gene ID" value="TDE_1494"/>
    </dbReference>
    <dbReference type="GeneID" id="2739895"/>
    <dbReference type="KEGG" id="tde:TDE_1494"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1433"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_12"/>
    <dbReference type="OMA" id="VMCTSVE"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="146" mass="16041" checksum="F5C928721CD6013A" modified="2011-07-27" version="1">MISKQDFPNINERAPEGKKPDGTPYKILVVDDSIFVTKQIGQILNSEGYEVVATAVDGFEGVEKYKELCPNVDLVTMDITMPKMDGLTALEQIMAFDKNAKVVMISALGKEELVKKALLLGAKNYIVKPLDRKKVLERVAGVLGIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-26" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>P61037</accession>
    <name>LNT1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apolipoprotein N-acyltransferase 1</fullName>
            <shortName evidence="1">ALP N-acyltransferase 1</shortName>
            <ecNumber evidence="1">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lnt1</name>
        <name type="ordered locus">TDE_1708</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972312.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679415.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61037"/>
    <dbReference type="SMR" id="P61037"/>
    <dbReference type="STRING" id="243275.TDE_1708"/>
    <dbReference type="EnsemblBacteria" id="AAS12223">
        <property type="protein sequence ID" value="AAS12223"/>
        <property type="gene ID" value="TDE_1708"/>
    </dbReference>
    <dbReference type="GeneID" id="2740880"/>
    <dbReference type="KEGG" id="tde:TDE_1708"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1633"/>
    <dbReference type="eggNOG" id="COG0815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019563_1_1_12"/>
    <dbReference type="OMA" id="FSWMLSD"/>
    <dbReference type="OrthoDB" id="1291198at2"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000178103" description="Apolipoprotein N-acyltransferase 1">
        <location>
            <begin position="1"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="225"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <sequence length="544" mass="63551" checksum="78E68ECACD6BFB56" modified="2004-04-26" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J32</accession>
    <name>Q73J32_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type I restriction-modification system, S subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hsdS</name>
        <name evidence="6" type="ordered locus">TDE_2744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973342.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680807.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2744"/>
    <dbReference type="REBASE" id="457199">
        <property type="entry name" value="S1.TdeVII"/>
    </dbReference>
    <dbReference type="REBASE" id="6394">
        <property type="entry name" value="S.TdeVII"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13261">
        <property type="protein sequence ID" value="AAS13261"/>
        <property type="gene ID" value="TDE_2744"/>
    </dbReference>
    <dbReference type="GeneID" id="2740963"/>
    <dbReference type="KEGG" id="tde:TDE_2744"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2590"/>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021095_10_4_12"/>
    <dbReference type="OMA" id="LMARCDE"/>
    <dbReference type="OrthoDB" id="827072at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="87"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Methylase_S" evidence="5">
        <location>
            <begin position="361"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS13261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="532" mass="61151" checksum="BFB4998E2161B7C3" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J75</accession>
    <name>Q73J75_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973299.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13218">
        <property type="protein sequence ID" value="AAS13218"/>
        <property type="gene ID" value="TDE_2701"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2701"/>
    <dbReference type="HOGENOM" id="CLU_3405984_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3733" checksum="DE8AF58F67E51085" modified="2004-07-05" version="1">MKQSYDKIILQSPFKSFKDWRGFVYARFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J85</accession>
    <name>Q73J85_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973289.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2691"/>
    <dbReference type="EnsemblBacteria" id="AAS13208">
        <property type="protein sequence ID" value="AAS13208"/>
        <property type="gene ID" value="TDE_2691"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2691"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2541"/>
    <dbReference type="eggNOG" id="COG5464">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071023_5_0_12"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="142" mass="16507" checksum="C05A7EE095D1F068" modified="2004-07-05" version="1">MICTFDAIGKNKPVYTFENICLEDKNTSLQDGTKKVIINAEAFKDTENKELKEFLEYLKTGKAKSEFTRRIEEMIQTVKQNEQARQEYRLMSTFEMDARYKGFSEGLKQKSIETAKLMKLKNFDTALIKEITGLPESEIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J91</accession>
    <name>Q73J91_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973282.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673509.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2684"/>
    <dbReference type="EnsemblBacteria" id="AAS13201">
        <property type="protein sequence ID" value="AAS13201"/>
        <property type="gene ID" value="TDE_2684"/>
    </dbReference>
    <dbReference type="GeneID" id="2739271"/>
    <dbReference type="KEGG" id="tde:TDE_2684"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2536"/>
    <dbReference type="eggNOG" id="ENOG502ZFDD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1244883_0_0_12"/>
    <dbReference type="OMA" id="LYVVWEV"/>
    <dbReference type="OrthoDB" id="2056210at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="222" mass="24356" checksum="4FBC374BA1130CB6" modified="2004-07-05" version="1">MAKFRIPLICTIAALALSFLLGLISGVRFSTILLRSLIISLISGGFVLGAQILLDHFVPDLFQPVNAEKSAKTETGKNLNISIDEPVEMPFIDDEEYDPESDMIEAEPVDEDSISDDATELSDADLIDEDFENIKDDSQASASKNGVSSGTEKKQEKNTVKELEELPDLQDFIPEDEPEQDDQMDFTQRGTSAFDVSTDLAGSGMDTNTMVNAIRTVLKRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JC2</accession>
    <name>Q73JC2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973251.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680699.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2653"/>
    <dbReference type="EnsemblBacteria" id="AAS13170">
        <property type="protein sequence ID" value="AAS13170"/>
        <property type="gene ID" value="TDE_2653"/>
    </dbReference>
    <dbReference type="GeneID" id="2741098"/>
    <dbReference type="KEGG" id="tde:TDE_2653"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2508"/>
    <dbReference type="eggNOG" id="COG3694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071040_0_1_12"/>
    <dbReference type="OMA" id="IDFALRP"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="257" mass="29589" checksum="9EB7927449FBCBFC" modified="2004-07-05" version="1">MNYCYKLLVLKIKEQLSFKNDSILWLIVRVLNSIMGILVLVFIFNKTLEIKGFNREECLLIYSLYTMSVGVFYCFFAWTLWYSNTYILQGKLSLVLKLPVNPFLYITFDNFALSEVFGIITGLLIFIYSAYTLNLGIVTILSLFLFLSAGTLGIIGIFLIVSSFSIKYPKIEEAFSPLMDMLDFAQYPISIYSAVIRFILTYVFPVSMIAFYPAAFSLNKYSFSIKFILLPIYSIIIFIIGYLLFIKSIKKYEGTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JE5</accession>
    <name>Q73JE5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2630</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973228.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680651.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2630"/>
    <dbReference type="EnsemblBacteria" id="AAS13147">
        <property type="protein sequence ID" value="AAS13147"/>
        <property type="gene ID" value="TDE_2630"/>
    </dbReference>
    <dbReference type="GeneID" id="2740804"/>
    <dbReference type="KEGG" id="tde:TDE_2630"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2486"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_12"/>
    <dbReference type="OMA" id="MPYYILA"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="93"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS13147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="317" mass="35705" checksum="89D114524CA9318A" modified="2004-07-05" version="1">MRIKYAVLFFALITAHFFLPRLMRADPFVFISSDGTEVASYSEEEITKYKAYYGLDKPLWKQYLHYLAGIASGNLGYSIYFKDTVVRLVFKRLIWTAGIVCVSLLFSLVLGLCLGSLSAWFIGKRLDGFLYHAMTGLSEIPSFLTANAILMLFIIRWRVLPTSGGITPFLPLSFTLPVIADIIKHAVLPALTLSLLKTPDFYFVTRSAMLRQLQKKYVETAQAKSLGAFTIAVKHCLPNASNPIITRFLLSLQTLFNGALIVENIFKYPGIGRLIRDAVFYRDYLLLQGIFFIVTVFILCISALGEAIYRRTGRSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JF5</accession>
    <name>Q73JF5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973218.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680628.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2620"/>
    <dbReference type="EnsemblBacteria" id="AAS13137">
        <property type="protein sequence ID" value="AAS13137"/>
        <property type="gene ID" value="TDE_2620"/>
    </dbReference>
    <dbReference type="GeneID" id="2740794"/>
    <dbReference type="KEGG" id="tde:TDE_2620"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2477"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2119432_0_0_12"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="139" mass="16163" checksum="F44DE2DE738762CB" modified="2004-07-05" version="1">MKNAVVYIHGKGGSADEALYYKKFFNDDYEVLGFDYKSELPWQACEEFQNYFDSLIPNYNEILLIANSIGAYFSMLALSEKPIKKALFVSPIVDMENIILHMMKRAKISEEELRLKKVINIQFGEPSSWKYLYTPVTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JH3</accession>
    <name>Q73JH3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2602</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973200.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667237.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2602"/>
    <dbReference type="EnsemblBacteria" id="AAS13119">
        <property type="protein sequence ID" value="AAS13119"/>
        <property type="gene ID" value="TDE_2602"/>
    </dbReference>
    <dbReference type="GeneID" id="2741306"/>
    <dbReference type="KEGG" id="tde:TDE_2602"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2460"/>
    <dbReference type="eggNOG" id="COG2825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124474_0_0_12"/>
    <dbReference type="OMA" id="DNPYILY"/>
    <dbReference type="OrthoDB" id="1752797at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS13119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="175" mass="20443" checksum="CB274E5C354A94A4" modified="2004-07-05" version="1">MNKKGTLIIIVMLLMSLGIYAQQITRFAVIDTGLIFDTFRRDAKAARDYQEKKEKFENQKKILESEIIQLRQKKVSAEADGQEAEVKKYEEKIKSKITLLMEYVKASNDELNMLRKNLINDDVFYSNLYESVRRVAESEGYTMVLSYEHNAGIIWYSPTVDITDKVIQELRKRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JH4</accession>
    <name>Q73JH4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Surface antigen, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73JH4"/>
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    <dbReference type="EnsemblBacteria" id="AAS13118">
        <property type="protein sequence ID" value="AAS13118"/>
        <property type="gene ID" value="TDE_2601"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.2459"/>
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    </dbReference>
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    <dbReference type="OMA" id="WNLKFVL"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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            <begin position="21"/>
            <end position="818"/>
        </location>
    </feature>
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        <location>
            <begin position="105"/>
            <end position="183"/>
        </location>
    </feature>
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        <location>
            <begin position="186"/>
            <end position="274"/>
        </location>
    </feature>
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        <location>
            <begin position="358"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS13118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="818" mass="93849" checksum="CB227598F52F07DF" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JI4</accession>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.2301"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
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            <begin position="1"/>
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        </location>
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        <location>
            <begin position="24"/>
            <end position="785"/>
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            <begin position="577"/>
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    </feature>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS12952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="785" mass="88215" checksum="5137726554C4C49B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JI6</accession>
    <name>Q73JI6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Treponemal membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
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            <taxon>Spirochaetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2432"/>
    <dbReference type="EnsemblBacteria" id="AAS12950">
        <property type="protein sequence ID" value="AAS12950"/>
        <property type="gene ID" value="TDE_2432"/>
    </dbReference>
    <dbReference type="GeneID" id="2739857"/>
    <dbReference type="KEGG" id="tde:TDE_2432"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2299"/>
    <dbReference type="eggNOG" id="ENOG5031CFT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_871359_0_0_12"/>
    <dbReference type="OMA" id="FWEASEA"/>
    <dbReference type="OrthoDB" id="2109676at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285800" evidence="2">
        <location>
            <begin position="23"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
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        <location>
            <begin position="318"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="356" mass="39297" checksum="05CAABFEAD24B535" modified="2004-07-05" version="1">MKKNYKLLILMSILVPLLFASCASKQKTQDIPPEPKVEEVKAPDVEKEDPKQEDVKPEVPKTDPLLANLKLFQGENGKVNKARKKAVELGADEAYPDFFNAADDVKQTADTAAETGNLKEAIAKYDEAVIKYETLSNLMSSAALRTEIEANGFAAYSPSDYADAERFSINTVDHYPLDHKMAKESSEDALKLYKKVVNKGYFEFAKTAKDSAKESKYYCDSIKVARSRKEEYNNAVKTYNRGKSAADKADYKEAYMSYDEAAKLFAKLYVEVSLKRAEAERAMAEAAKRQQESSDLALEADKEAPLTEGGEGFTEGDLDLQNLSTPQTGAPVENINTKGDAPANTENNQTTTEGGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JJ7</accession>
    <name>RPOB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="1">RNAP subunit beta</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoB</name>
        <name type="ordered locus">TDE_2421</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973020.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680361.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JJ7"/>
    <dbReference type="SMR" id="Q73JJ7"/>
    <dbReference type="STRING" id="243275.TDE_2421"/>
    <dbReference type="EnsemblBacteria" id="AAS12939">
        <property type="protein sequence ID" value="AAS12939"/>
        <property type="gene ID" value="TDE_2421"/>
    </dbReference>
    <dbReference type="GeneID" id="2739846"/>
    <dbReference type="KEGG" id="tde:TDE_2421"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2288"/>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_4_3_12"/>
    <dbReference type="OMA" id="FMTWEGY"/>
    <dbReference type="OrthoDB" id="9601at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000224118" description="DNA-directed RNA polymerase subunit beta">
        <location>
            <begin position="1"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <sequence length="1167" mass="131849" checksum="0C72F1182AB2F1D4" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JK7</accession>
    <name>Q73JK7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="6">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glgP</name>
        <name evidence="7" type="ordered locus">TDE_2411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973010.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680347.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2411"/>
    <dbReference type="CAZy" id="GT35">
        <property type="family name" value="Glycosyltransferase Family 35"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12929">
        <property type="protein sequence ID" value="AAS12929"/>
        <property type="gene ID" value="TDE_2411"/>
    </dbReference>
    <dbReference type="GeneID" id="2739836"/>
    <dbReference type="KEGG" id="tde:TDE_2411"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2277"/>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010198_1_1_12"/>
    <dbReference type="OMA" id="KHKRTFT"/>
    <dbReference type="OrthoDB" id="137158at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="817" mass="93905" checksum="8BFDAB62C4907D32" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JN1</accession>
    <name>Q73JN1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972985.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675857.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2386"/>
    <dbReference type="EnsemblBacteria" id="AAS12904">
        <property type="protein sequence ID" value="AAS12904"/>
        <property type="gene ID" value="TDE_2386"/>
    </dbReference>
    <dbReference type="GeneID" id="2740688"/>
    <dbReference type="KEGG" id="tde:TDE_2386"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2254"/>
    <dbReference type="HOGENOM" id="CLU_1309641_0_0_12"/>
    <dbReference type="OrthoDB" id="2131918at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="210" mass="24979" checksum="A4C7176837F1CDA0" modified="2004-07-05" version="1">MMIKKKKEIFFLNIIFIFLLILFIFMPVILPKNYFMAIGFNISFYIIFQIISFALYSFYYKEDKANIKSLIAGVKENFIEALIISVIKLSIISALIFLLRYFLKLKTITGYFFSVFILFIFFIFELSLFWYPAIIGLQKKKKGIICNLKKSFYLFFENSFFTYKILFFSTLKLLISFPTLFIFPGIAGIIFYIAENYKLINYKPTMEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JS4</accession>
    <name>Q73JS4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn_dep_PLPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973084.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680452.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2486"/>
    <dbReference type="EnsemblBacteria" id="AAS13003">
        <property type="protein sequence ID" value="AAS13003"/>
        <property type="gene ID" value="TDE_2486"/>
    </dbReference>
    <dbReference type="GeneID" id="2741459"/>
    <dbReference type="KEGG" id="tde:TDE_2486"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2352"/>
    <dbReference type="HOGENOM" id="CLU_1467598_0_0_12"/>
    <dbReference type="OrthoDB" id="2177602at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_dep_PLPC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="184" mass="22048" checksum="1122FBED679A4B29" modified="2004-07-05" version="1">MPDKISHILISKKYLEKINDIKGKEYFYYGAIYPDLYDLSKKEEYYKSHFIQKGSGYNSKLLKNFIKKHSYAPPSFLKGVDFHIFTDHFVSKNLNKYYSFYTEIKNKTDIELSKILSDYALYHCRNEKIIPVILKEENDEQIQSSFYEFEKYRKTDIGDISSVNNNYLEFIDEIIDKYLKQNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JX3</accession>
    <name>Q73JX3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973138.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680507.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2540"/>
    <dbReference type="EnsemblBacteria" id="AAS13057">
        <property type="protein sequence ID" value="AAS13057"/>
        <property type="gene ID" value="TDE_2540"/>
    </dbReference>
    <dbReference type="GeneID" id="2739052"/>
    <dbReference type="KEGG" id="tde:TDE_2540"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2403"/>
    <dbReference type="eggNOG" id="COG4640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_318290_0_0_12"/>
    <dbReference type="OMA" id="WTQNLYW"/>
    <dbReference type="OrthoDB" id="1159019at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022601">
        <property type="entry name" value="DUF3160"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11369">
        <property type="entry name" value="DUF3160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01325">
        <property type="entry name" value="DUF3160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="928" mass="105695" checksum="3A5E932A147F1951" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JX8</accession>
    <name>Q73JX8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pyk</name>
        <name evidence="15" type="ordered locus">TDE_2535</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 12"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973133.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680502.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2535"/>
    <dbReference type="EnsemblBacteria" id="AAS13052">
        <property type="protein sequence ID" value="AAS13052"/>
        <property type="gene ID" value="TDE_2535"/>
    </dbReference>
    <dbReference type="GeneID" id="2739047"/>
    <dbReference type="KEGG" id="tde:TDE_2535"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2398"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_12"/>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="OrthoDB" id="1098983at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="13">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="14">
        <location>
            <begin position="355"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AAS13052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="471" mass="51329" checksum="37B2DB343D7EE931" modified="2004-07-05" version="1">MKKTKIVCTIGPASDSERVLAEMFKAGLNVCRLNFSHGSHEEHKVKIDRIKKIREELKMPIALLLDTKGPEIRLGLFEKPVEIVQGQEFIITTRDVIGTNQICSISYKNIAAEIKPKSRILINDGLLELQVIDILNDTDIECVAVNSGTLSSRKGVNIPGLRVNLPYMSEKDISDIEFGIENDVDFIAASFTQRADDIIQIRKLLEKHKSTIAVIAKIENQEGLDNIDEILAEADGIMVARGDMGVEIEPEKIPHLQKQLIKKANLAGKPVITATQMLESMTHNLRPTRAEVTDVANAILDGTSAVMLSGETAAGEYPVETVAMMTSIANSIEETLDYEKLFAENASLHETTITNAIARATCSTALALDANAIITASASGITPRALSKFKPRVPIIAITESPQVMRKMALDWDVYPVLADPIKSTDNMFDVCSQIAKDTGHVKKGDIAILTAGIPIGKAGSTNLLKVEIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K00</accession>
    <name>Q73K00_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973163.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680543.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2565"/>
    <dbReference type="EnsemblBacteria" id="AAS13082">
        <property type="protein sequence ID" value="AAS13082"/>
        <property type="gene ID" value="TDE_2565"/>
    </dbReference>
    <dbReference type="GeneID" id="2739930"/>
    <dbReference type="KEGG" id="tde:TDE_2565"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2424"/>
    <dbReference type="eggNOG" id="ENOG5031CD2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_946430_0_0_12"/>
    <dbReference type="OrthoDB" id="908462at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="293" mass="33617" checksum="61C91C4331B26A53" modified="2004-07-05" version="1">MKKLSLKLLGLFLFLFCFVNFLIAGDLEDHSIKANPENPDCIYEKARLGDCLIHMAKITSPSKGSAPAVEILFTSDFKWEPCAPHEGWGKEGKTYQYRETEVPGSSVFLGITNKINDVVYFKVEGVHPFDLPIYDEPSEAKILERFIFFKFTAYAAKGGIFENALNNLMCALDTHTKLLYTYGMPSEYKKIIGNNYIPQKWLPYEIHSNTAEAKLKFYEYDPIGFVSLEKTYDFLGVKTNVHLYDWWNESVGAGSSMKTVKEKRFMPRLSGEALEDWTIRDASRPVRSPYRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K54</accession>
    <name>Q73K54_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YbaK/prolyl-tRNA synthetase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972967.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680290.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2368"/>
    <dbReference type="EnsemblBacteria" id="AAS12886">
        <property type="protein sequence ID" value="AAS12886"/>
        <property type="gene ID" value="TDE_2368"/>
    </dbReference>
    <dbReference type="GeneID" id="2739977"/>
    <dbReference type="KEGG" id="tde:TDE_2368"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2236"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_0_3_12"/>
    <dbReference type="OMA" id="VMLPATG"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="27"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="153" mass="17090" checksum="D3C4101D9B3A9995" modified="2004-07-05" version="1">MGLKEARDHLRLFSLEERIIEFDTSSATVELAAEAVGCKPEFIVKTLAFMVKEDPILILLAGSARIDNAKFRKTFHCKTKMMNEEQLFNFIGHPAGGVCPFGLKTQVPVYIDESIRPLDWVYPAAGTENTAVRMNVQELEKASKAVTWVSVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KA4</accession>
    <name>Q73KA4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2315</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972915.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2315"/>
    <dbReference type="EnsemblBacteria" id="AAS12834">
        <property type="protein sequence ID" value="AAS12834"/>
        <property type="gene ID" value="TDE_2315"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2315"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2184"/>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_1_0_12"/>
    <dbReference type="OMA" id="PLEWHMI"/>
    <dbReference type="OrthoDB" id="1423012at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="37"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="275" mass="31493" checksum="3B09E5F03AAD7071" modified="2004-07-05" version="1">MEKAAQCVIISYCLYFKPDYIIDKCEVIYMKDDIKINLEEVHRRMEKACKACGRDLKEVRLLMATKTVTPERILKAFEYGELLIGENKVQELCEKYEPLSSVKHETHFIGHLQTNKIKDVIKYADCIESVDRLDLAEKLSKRLESEGKTMDILIQVNTSQEESKFGCKPEEALALTEKIAKLPCLKIKGLMTIGLFSDDMDKVRLCFKLLQKIRKEITEKNIPNVSMEVVSMGMTGDLEVAIEEGSTLIRVGTAIFGKRNYPDSYYWNENAKIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KC8</accession>
    <name>Q73KC8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972890.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680200.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2290"/>
    <dbReference type="EnsemblBacteria" id="AAS12809">
        <property type="protein sequence ID" value="AAS12809"/>
        <property type="gene ID" value="TDE_2290"/>
    </dbReference>
    <dbReference type="GeneID" id="2740255"/>
    <dbReference type="KEGG" id="tde:TDE_2290"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2160"/>
    <dbReference type="eggNOG" id="COG1329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048259_1_1_12"/>
    <dbReference type="OMA" id="DMKVMIP"/>
    <dbReference type="OrthoDB" id="1942592at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042215">
        <property type="entry name" value="CarD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CarD_TRCF" evidence="2">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="208" mass="23711" checksum="349FD75E59C8EDCB" modified="2004-07-05" version="1">MSKKFVFSAKEVVVYPGQGVGTITDITKKEIAGEVIDYYVIYLSDSDMTVLVPITGIDNLGIRRIVTKAEAEAALKFLSEDFEPIPIDWKARYQMNMDLFKSGKILDTGSVVRSLYQRSKTKELPIQERKLYDSAYRIFQDEIAAALKMTKTEVEAAIHLHLEPLGGPIEKFKDDYDDDDLIANDDERLDDDDMDEDDIEDSDMYEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KF1</accession>
    <name>Q73KF1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HRDC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972867.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680156.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2267"/>
    <dbReference type="EnsemblBacteria" id="AAS12786">
        <property type="protein sequence ID" value="AAS12786"/>
        <property type="gene ID" value="TDE_2267"/>
    </dbReference>
    <dbReference type="GeneID" id="2740017"/>
    <dbReference type="KEGG" id="tde:TDE_2267"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2139"/>
    <dbReference type="eggNOG" id="COG0514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137324_0_0_12"/>
    <dbReference type="OMA" id="FIVFTDE"/>
    <dbReference type="OrthoDB" id="1927534at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="1">
        <location>
            <begin position="73"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="160" mass="18431" checksum="31D63E221BAB8854" modified="2004-07-05" version="1">MQFKLFVIPISNYLKTIDEMNIFLRSHKIITHTKEFVNSGENSFYSILVEYLDSPISAADKEKSSIDYKDILKPEEFAFFPYLRDERKKLAEQAGIPIYAVLNNAQLSQIAVEKPKSISELSKIEGIGQGKCEKFGEAFLQAVHNYEKKRQSISQDNRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KG0</accession>
    <accession>Q6QE73</accession>
    <name>Q73KG0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Surface antigen BspA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972858.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680126.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2258"/>
    <dbReference type="EnsemblBacteria" id="AAS12777">
        <property type="protein sequence ID" value="AAS12777"/>
        <property type="gene ID" value="TDE_2258"/>
    </dbReference>
    <dbReference type="GeneID" id="2740008"/>
    <dbReference type="KEGG" id="tde:TDE_2258"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2131"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034334_6_2_12"/>
    <dbReference type="OrthoDB" id="956253at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="355" mass="37232" checksum="F5FB21E3A61617CD" modified="2004-07-05" version="1">MKNANTKSRVSSVSKLRARLLTSWAAVSVLAASLLFTGLLTGCPGTAGGGTPSVPVDPAAILKTDGNGKIIGYKCAKEELPAHLVIPAKIGDEEIKEIGAWVFDGCTGLRNVTLPASLTQIDEKAFRGCTGLTSISLPANLTEIGEFAFYDCTGLTSLDLSACTSLTTIGEYAFEGCTGLTSISLPANLTTIGEGAFAGCTGLTSIDLSASTSLTTIGEGAFEGCKSLTSITLPANLTKIDKYTFSDCTGLTSITLPANLTQIGEYAFYDCKGLTSVHLPASLTTIDQYAFYGCGGLASAVFEDKNYWKVYDDDSYSGTSTSINSSDLNTAATAAKYLREETDEGGYCDKYWKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KG4</accession>
    <name>Q73KG4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972854.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12773">
        <property type="protein sequence ID" value="AAS12773"/>
        <property type="gene ID" value="TDE_2254"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2254"/>
    <dbReference type="HOGENOM" id="CLU_2848527_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="65" mass="7398" checksum="FC1E5173B7CA408F" modified="2004-07-05" version="1">MAKIFFCLWFSFVFNPTDGKTLPRLAIKTASGMSAKKKNKNLFCIRIKSSIIIILPKIYLVCKTV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KS3</accession>
    <name>Y2144_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0597 protein TDE_2144</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_2144</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0597 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972745.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679977.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KS3"/>
    <dbReference type="STRING" id="243275.TDE_2144"/>
    <dbReference type="PRIDE" id="Q73KS3"/>
    <dbReference type="EnsemblBacteria" id="AAS12664">
        <property type="protein sequence ID" value="AAS12664"/>
        <property type="gene ID" value="TDE_2144"/>
    </dbReference>
    <dbReference type="GeneID" id="2739130"/>
    <dbReference type="KEGG" id="tde:TDE_2144"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2025"/>
    <dbReference type="eggNOG" id="COG3681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051840_0_0_12"/>
    <dbReference type="OMA" id="LSGMICD"/>
    <dbReference type="OrthoDB" id="1326279at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01845">
        <property type="entry name" value="UPF0597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021144">
        <property type="entry name" value="UPF0597"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30501">
        <property type="entry name" value="PTHR30501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006054">
        <property type="entry name" value="UCP006054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000339864" description="UPF0597 protein TDE_2144">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01845"/>
        </source>
    </evidence>
    <sequence length="431" mass="45648" checksum="CDCB4EDECC266138" modified="2004-07-05" version="1">MSLDKSKHEKYVQILREELVPALGCTEPIAIAYTAANLRKIMGGIPDEILIESSGNIIKNAKSVIVPNTGGMKGMEASALIGLIGGNADKGLEVLADVTEEHVKLAHEYLAKSCTKLKLMDTPASLHIRITGKLNGDTGVAELIHQHTNIVLLKKNDEIIFEKPFSLESAAGALTDRTCLNVKDILDFADTVPVDEVSPIIMRQVEYNMRVSEDGLKTSYGIETGKNILKYNQKKGDDFSVKVQAEGEVAAASDARMCGCSYPVITNSGSGNQGLAVSVPVVVYARENKISEEKLIRCLIVSNLLAIHQKTGIGRLSAYCGAVTAGAACAAAITYMKGGSYEQVCGTIVNTLGTVSGILCDGAKQSCAAKIASALDSALFSHELAMDGNFFAGGDGIVKDDIEKTIAGIGVVAAQGMHKTDEVVLQVMLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KU3</accession>
    <name>Q73KU3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-dependent Clp protease, ATP-binding subunit ClpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">clpA</name>
        <name evidence="8" type="ordered locus">TDE_2124</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972725.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679937.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2124"/>
    <dbReference type="EnsemblBacteria" id="AAS12644">
        <property type="protein sequence ID" value="AAS12644"/>
        <property type="gene ID" value="TDE_2124"/>
    </dbReference>
    <dbReference type="GeneID" id="2739383"/>
    <dbReference type="KEGG" id="tde:TDE_2124"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2007"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_2_12"/>
    <dbReference type="OMA" id="IMQDGGD"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013461">
        <property type="entry name" value="ClpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02639">
        <property type="entry name" value="ClpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="229"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="522"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="7">
        <location>
            <begin position="689"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="785" mass="87753" checksum="F8C5685FA5904310" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L07</accession>
    <name>Q73L07_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972661.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2059"/>
    <dbReference type="EnsemblBacteria" id="AAS12572">
        <property type="protein sequence ID" value="AAS12572"/>
        <property type="gene ID" value="TDE_2059"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2059"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1944"/>
    <dbReference type="HOGENOM" id="CLU_2830004_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="66" mass="7776" checksum="7A7106EEF569C702" modified="2004-07-05" version="1">MYYEILRREGKSENSLLYNSILLSAFSISGADALRFSCFLYLISDLFLIKSLLFRLWGLAFFLRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L18</accession>
    <name>Q73L18_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972650.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679821.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2048"/>
    <dbReference type="EnsemblBacteria" id="AAS12561">
        <property type="protein sequence ID" value="AAS12561"/>
        <property type="gene ID" value="TDE_2048"/>
    </dbReference>
    <dbReference type="GeneID" id="2740642"/>
    <dbReference type="KEGG" id="tde:TDE_2048"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1934"/>
    <dbReference type="eggNOG" id="ENOG5033PNA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_585163_0_0_12"/>
    <dbReference type="OMA" id="NQKRHEY"/>
    <dbReference type="OrthoDB" id="1121997at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="467" mass="54080" checksum="AE3C0D73796D28C6" modified="2004-07-05" version="1">MENRKNFVEELSVILETKRNEFNSQILPKVRENYNIQSSALHAVRSTLLKKRVIHDDPYKYDSKMTEVEIPSKENFADSEKASVIGTRLAHYETMLEFVNNYYQFNTEFLTPKRIAILLDLNSTFIWSDFTNTSNHTNTRAIADIINNLFKGPDQLSSSLLRDSVAHLAKSETYINTQLKSLSIFHREEYKLLIRREIIPSVKITKEDCANPSNILREIKKIFTLKLKKKPFYTDLIVEIIREDYGDDSAILQQEVLSRLEVKPKESSFENKEVNHRPILISGLRVLSNSAPHLKAALDKIKSNQELVYKSENTVFRKIAEIFRQILKLEPPEKHITIIITDNINQNTKKQTINYSVFEKEVLQKIALFQSILMPNSVVNQKIKTMPNELLFNSLTKYISDSNEMLKQLGGLDEFYKSVKPELRSKIRGIKIEITTITNSIIKANQYRAEYQALSEEVSQMKKLGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L50</accession>
    <name>Q73L50_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972618.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679781.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2015"/>
    <dbReference type="EnsemblBacteria" id="AAS12529">
        <property type="protein sequence ID" value="AAS12529"/>
        <property type="gene ID" value="TDE_2015"/>
    </dbReference>
    <dbReference type="GeneID" id="2740362"/>
    <dbReference type="KEGG" id="tde:TDE_2015"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1903"/>
    <dbReference type="HOGENOM" id="CLU_785117_0_0_12"/>
    <dbReference type="OrthoDB" id="2170101at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="373" mass="44317" checksum="CC1347A0EC414446" modified="2004-07-05" version="1">MKILRNMIFIFMLVLLVSCTKRESKMIVNDVQQNTITESSKNIDKTPKEEKIEFDTSGSGKKSCFPYGANIVNNTNYPSDINFGDISLFPTDARYLNENFRYKKIISWRRWDEPAIKRKLKSYAETSEGENFIGHKYSSADIGLMQLESAILFDEDQKKIIEVEDSPYYDGKIVKLNEYNDLGLQTNIYDFRLDNEIILFSEEFYNELKNIDDKLMYSYEYIDIKDNPNILKYNHYFYHSKGKKLLESGRISKTLNMKNTMDNNFFIARANKSLKYYLKETHSYALFYYDEMGRLSKIEHLPTSMGWKFYDVEYDGNKLLEGKLKFDEKSDAYFKYVYTKHDKNDNWIEAKIFYDDDTEASYTAIREIEYYEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L56</accession>
    <name>Q73L56_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972612.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679769.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2009"/>
    <dbReference type="EnsemblBacteria" id="AAS12523">
        <property type="protein sequence ID" value="AAS12523"/>
        <property type="gene ID" value="TDE_2009"/>
    </dbReference>
    <dbReference type="GeneID" id="2740356"/>
    <dbReference type="KEGG" id="tde:TDE_2009"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1897"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074356_1_0_12"/>
    <dbReference type="OMA" id="EFDHEKY"/>
    <dbReference type="OrthoDB" id="963283at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033399">
        <property type="entry name" value="Put_LolA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17131">
        <property type="entry name" value="LolA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284580" evidence="1">
        <location>
            <begin position="24"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="261" mass="30171" checksum="7F11DC42F0894499" modified="2004-07-05" version="1">MKRIKHLIVLTIFAAAAVSFAFAQELTGREIMQKASNREKAVTDSFKMRMTLINSSGKKRVREVTAYSKDYGKEEKTVMVFLLPADVKGVGYLSFSYDDESKSDDRWLYMPALKKAKRISGSSSQDYFMGTDFTYDDMSGRKVDDYKHSLLGEEKIDSKDCWKIESIPVKKSMYSKYVSWIDKESLLNIKAEFYDEQGSILKVLTVSGIEKKEGFWTGNKMEMNNLQKKHKTLIEILKHEFNKEIPDSYFRVNSLEEGKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LB2</accession>
    <name>Q73LB2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972556.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674943.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1953"/>
    <dbReference type="EnsemblBacteria" id="AAS12467">
        <property type="protein sequence ID" value="AAS12467"/>
        <property type="gene ID" value="TDE_1953"/>
    </dbReference>
    <dbReference type="GeneID" id="2741516"/>
    <dbReference type="KEGG" id="tde:TDE_1953"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1845"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_6_0_12"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="213" mass="24251" checksum="FF2732BD0F524349" modified="2004-07-05" version="1">MEACKRTADTKDLILKSAKKYFLEYGYQAAPLRKIVSEAGFTPGALYGYFNSKEELFYAITDPVANKLMEVLDRIRSEMDALPKKERLYGMGKVYYPNIPKIVDILIADRDAVKLIVNGAKGTKYENFLDTIAGRNALTISKTVKNIEEKNICPIKEQTIEVLMEGYIATLFRLIISDKDRETIIRCMEMIGKIYETGIIALIQKEWGNENDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LC6</accession>
    <name>Q73LC6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972542.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12453">
        <property type="protein sequence ID" value="AAS12453"/>
        <property type="gene ID" value="TDE_1939"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1939"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1832"/>
    <dbReference type="eggNOG" id="ENOG5031C8X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1102401_0_0_12"/>
    <dbReference type="OMA" id="MNITTQV"/>
    <dbReference type="OrthoDB" id="1165409at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="242" mass="26910" checksum="2307C034F941814C" modified="2004-07-05" version="1">MYASAFFVLCVALVMNITTQVPLAGFIPVVRWIDVAVNAVAAGLCVFLFIKPGCKMISYLLFFIEGGITAHMGFVGIGTLLFTAGCVIVFVNGDFKTRYKEKIAALCLYWILITIGLYFSFNIKMAIFEIALTLFHFGLLVCLYKKLESKLSFLLPVEEIISPEIPLPVKGSVLRLSDYGISERQKFFIQGTVNGGKTYEELAAEYHVSTSVVKKDMAAACRLLGVTNKEDLRILLLQYKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LE4</accession>
    <name>Q73LE4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972524.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669743.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1921"/>
    <dbReference type="EnsemblBacteria" id="AAS12435">
        <property type="protein sequence ID" value="AAS12435"/>
        <property type="gene ID" value="TDE_1921"/>
    </dbReference>
    <dbReference type="GeneID" id="2740419"/>
    <dbReference type="KEGG" id="tde:TDE_1921"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1818"/>
    <dbReference type="eggNOG" id="ENOG502ZJPR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154627_0_0_12"/>
    <dbReference type="OMA" id="MIQFYFL"/>
    <dbReference type="OrthoDB" id="1748591at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="136" mass="15079" checksum="2A13ABDFCABF72D3" modified="2004-07-05" version="1">MLPFYFLSITTNLIMGLILVFFDKTVRGDEPADRENRYPVLRDSTFLLLLTIFSGFTAISKMLSPVGTNIVILGDFLPVVAGLAGSIVFLGRYLESNSNITLPDFFGLVKNYDEIIGYVCLASSVLHLLFSKAIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LH1</accession>
    <name>Q73LH1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972495.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1892"/>
    <dbReference type="EnsemblBacteria" id="AAS12406">
        <property type="protein sequence ID" value="AAS12406"/>
        <property type="gene ID" value="TDE_1892"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1892"/>
    <dbReference type="HOGENOM" id="CLU_3405977_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3299" checksum="BF15C1AE84F3C0E0" modified="2004-07-05" version="1">MREKEGVIGGEYSQQSFKAKPCSERGVLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LI9</accession>
    <name>Q73LI9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972477.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957085.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1873"/>
    <dbReference type="EnsemblBacteria" id="AAS12388">
        <property type="protein sequence ID" value="AAS12388"/>
        <property type="gene ID" value="TDE_1873"/>
    </dbReference>
    <dbReference type="GeneID" id="2740062"/>
    <dbReference type="KEGG" id="tde:TDE_1873"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1774"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084787_0_0_12"/>
    <dbReference type="OMA" id="KITILCH"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="288" mass="34387" checksum="3404347BBA31D45B" modified="2004-07-05" version="1">MNKKVIKDLCILFMLYILVFYINSYIHKFLLNNFYNCYYALFGKYNKIVDLLISLLFIIVLYLLYLKEMKIIFTYKKLNFFFIVKSLIYILSIGMIYYIIYFIFDNAFLFNFFKYFNDILSGKKNITIYDILILEKSLRPCFEPFMFIATVIISPIFEEILYRGLMYNKLKEISNAFIGVLISSILFALLHIPKYGFGINTFFLFLVGILLAYCYEKSNNIYVPIFVHSINNFFIFLFNYVYFYFLIIIYFIIFIAGIIIAIQEIKKHLKARKTFNLVQSASLSESEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LJ2</accession>
    <name>Q73LJ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972474.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957082.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1870"/>
    <dbReference type="EnsemblBacteria" id="AAS12385">
        <property type="protein sequence ID" value="AAS12385"/>
        <property type="gene ID" value="TDE_1870"/>
    </dbReference>
    <dbReference type="GeneID" id="2740059"/>
    <dbReference type="KEGG" id="tde:TDE_1870"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1772"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084787_0_0_12"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="278" mass="32911" checksum="20E420ADEEC1D8DB" modified="2004-07-05" version="1">MNNNIKKAFLNFWWLSSILLFLILWKLVQILNPDMSIPDLKKRYLYGIIVIVDLYWVVFCFKINSINVKEYFKFKNPKFLLILKYTLIVFAISAIYYQFNTLILDIKYSFNFFQENMGKISYYDVFRNPNLWKYVLICGMIFAPVAEELFFRYYMYNNLKYKYSSVFIANIISSVIFGFFHISMYGYDLNAVMMISIGGMALAYCYEKTRTIWTPMIMHSLHNGLVSFGQCLTTPFFTILTLIYIILGGSIGIIELIKHLRRRKQNAIQTDTLPHVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LN1</accession>
    <name>Q73LN1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1797</name>
        <name evidence="2" type="ordered locus">TDE_1831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405</strain>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972401.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972435.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1797"/>
    <dbReference type="EnsemblBacteria" id="AAS12312">
        <property type="protein sequence ID" value="AAS12312"/>
        <property type="gene ID" value="TDE_1797"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12346">
        <property type="protein sequence ID" value="AAS12346"/>
        <property type="gene ID" value="TDE_1831"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1797"/>
    <dbReference type="KEGG" id="tde:TDE_1831"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1710"/>
    <dbReference type="eggNOG" id="ENOG502Z8C2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1337018_0_0_12"/>
    <dbReference type="OMA" id="YTEIECE"/>
    <dbReference type="OrthoDB" id="1790062at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="205" mass="24217" checksum="36F0B7B7AC998814" modified="2004-07-05" version="1">MGLISCFVKTKEEKFWCWFCKNSQLIYNYEINQEKIFNELQIQLHKINPDLTFEISSVKNGKRDFVISADGILDAFPAVEKLYLLKPKLSEWTFIKFRPRRKIENSIKIEDKEVCPNDIRFMFIKDEDKSKIGIVLFCNGYTEIECEIYSQIGFLFLDECLGEYDVEKFIGTIIIQGFDSEYFNDSIKIEFLATEFDKIKVNIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LP4</accession>
    <name>Q73LP4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SH3b domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972422.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957064.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1818"/>
    <dbReference type="EnsemblBacteria" id="AAS12333">
        <property type="protein sequence ID" value="AAS12333"/>
        <property type="gene ID" value="TDE_1818"/>
    </dbReference>
    <dbReference type="GeneID" id="2739248"/>
    <dbReference type="KEGG" id="tde:TDE_1818"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1728"/>
    <dbReference type="eggNOG" id="ENOG5031D0F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_849763_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3b" evidence="1">
        <location>
            <begin position="45"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="319" mass="37826" checksum="FBC2CD78729F4F85" modified="2004-07-05" version="1">MKQKKVVSMVCVLVLIISAVTLYSEEIRTSKYYGVHFITEIKENNVNVREAPSLEANVIVTLNEGHKIRITGISKVNEKIDGYSGYWFRIEILDFKAKELYSLGKWVFSKYVKDKDITPSIIRLKKSNEILNNQVSSLELLIEKNGRTRTVKVPVERKKNRYTFVWNDYPNAEFMYYDVPGVYRWIPEFNEIRHVSYYSIDKWSSDEFTEDYRYCISDEGSAPGIRGVIVRNLKNGRIIFEGSYYSSWNLDGYEIDIVYSPSEWDIKNGQVDQETLKHFTDYQKSHKLKEFEYILVKYRYNFVEKKRKFIGYEIMFNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LR7</accession>
    <name>Q73LR7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FunZ protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972399.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957049.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1795"/>
    <dbReference type="EnsemblBacteria" id="AAS12310">
        <property type="protein sequence ID" value="AAS12310"/>
        <property type="gene ID" value="TDE_1795"/>
    </dbReference>
    <dbReference type="GeneID" id="59369457"/>
    <dbReference type="KEGG" id="tde:TDE_1795"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1708"/>
    <dbReference type="eggNOG" id="ENOG502ZNHY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024253_0_0_12"/>
    <dbReference type="OMA" id="FRTHHAL"/>
    <dbReference type="OrthoDB" id="690107at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="536" mass="63314" checksum="A1579D8AD30A71C3" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LS7</accession>
    <name>Q73LS7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972389.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12300">
        <property type="protein sequence ID" value="AAS12300"/>
        <property type="gene ID" value="TDE_1785"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1785"/>
    <dbReference type="HOGENOM" id="CLU_3298095_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="40" mass="4741" checksum="2AAB987D983FA0C5" modified="2004-07-05" version="1">MHSIAFYTMLANVLYSIIQKVLFDESMSCFFYIDFISFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LU7</accession>
    <name>Q73LU7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972369.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1765"/>
    <dbReference type="EnsemblBacteria" id="AAS12280">
        <property type="protein sequence ID" value="AAS12280"/>
        <property type="gene ID" value="TDE_1765"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1765"/>
    <dbReference type="HOGENOM" id="CLU_2290432_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="101" mass="11790" checksum="AAD6FE0C598EAA94" modified="2004-07-05" version="1">MIFITIFLLLAIYFPFLFSETKKSQVYFNIIIIVSNIALMFLSIFSFYLVRSLSFIGVLIYINLSILIILLNILFTITNIIKTKKIGKLFFFTANSIFHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M17</accession>
    <name>Q73M17_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1694"/>
    <dbReference type="EnsemblBacteria" id="AAS12209">
        <property type="protein sequence ID" value="AAS12209"/>
        <property type="gene ID" value="TDE_1694"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1694"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1620"/>
    <dbReference type="HOGENOM" id="CLU_3174426_0_0_12"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="47" mass="5583" checksum="A084B6B6A3F93961" modified="2004-07-05" version="1">MVPLCLSAEFAFRQTSHYCMQFVNKLREKTFFANCYLLQKVFIGETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M26</accession>
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            <fullName evidence="4">GGDEF domain protein</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1685</name>
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    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="SMR" id="Q73M26"/>
    <dbReference type="STRING" id="243275.TDE_1685"/>
    <dbReference type="EnsemblBacteria" id="AAS12200">
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        <property type="gene ID" value="TDE_1685"/>
    </dbReference>
    <dbReference type="GeneID" id="2740140"/>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.1612"/>
    <dbReference type="eggNOG" id="COG3292">
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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            <end position="941"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS12200.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="987" mass="113465" checksum="B295ECBAE3E78016" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M45</accession>
    <name>Q73M45_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">TDE_1665</name>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="73" mass="8685" checksum="2746B5091197FF03" modified="2004-07-05" version="1">MRIKIQKHIFFNFILYLFTKQKSRSRDIPFTSAFLYYRLYRKPINRYIGSRFIGDASIFLLGICGGCGREKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M77</accession>
    <name>Q73M77_TREDE</name>
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        <submittedName>
            <fullName evidence="6">Citrate lyase, beta subunit</fullName>
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    <gene>
        <name evidence="6" type="primary">citE</name>
        <name evidence="6" type="ordered locus">TDE_1632</name>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <cofactor evidence="1">
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        <property type="gene ID" value="TDE_1632"/>
    </dbReference>
    <dbReference type="GeneID" id="2739741"/>
    <dbReference type="KEGG" id="tde:TDE_1632"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1560"/>
    <dbReference type="eggNOG" id="COG2301">
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0008815">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
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        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
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        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="5"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="66"/>
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        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="289" mass="31948" checksum="D61BF37A3989384B" modified="2004-07-05" version="1">MKNRRSMLFMPGNNPGMLVSADILGADSIIYDLEDAVSLDEKDSARTLVRNALSFLKFTHSEITVRINPIDSPYWEKDLEAIIPVLPDGIVIPKASVDAVHSVEQKINEIKKAHNITKNFSFLMLVESARGIMDVNSIAKASSLIQGLLLGGEDYSVDMGIQRTRLSKELEYARFSLTTAAHAYGLDSLDTPFTDVEDFEGLRLDTAFSKSIGFSGRLVINPRQVEEIHKIFSPSSAEIERAEAILQAAEEAKQKGLGVFSFKGKMVDLPVIKRAQALYDSAKNWGLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ME4</accession>
    <name>Q73ME4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972170.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1564"/>
    <dbReference type="EnsemblBacteria" id="AAS12081">
        <property type="protein sequence ID" value="AAS12081"/>
        <property type="gene ID" value="TDE_1564"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1564"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1498"/>
    <dbReference type="HOGENOM" id="CLU_3359076_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="40" mass="4732" checksum="2F5590B8A1EFE483" modified="2004-07-05" version="1">MCAVLPTLAYFYILCNNKNYKKASGFLRARCLLRPFKQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ME5</accession>
    <name>Q73ME5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972169.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679233.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1563"/>
    <dbReference type="EnsemblBacteria" id="AAS12080">
        <property type="protein sequence ID" value="AAS12080"/>
        <property type="gene ID" value="TDE_1563"/>
    </dbReference>
    <dbReference type="GeneID" id="2739313"/>
    <dbReference type="KEGG" id="tde:TDE_1563"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1497"/>
    <dbReference type="eggNOG" id="ENOG5031D6B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1081586_0_0_12"/>
    <dbReference type="OrthoDB" id="1124005at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="246" mass="28293" checksum="7D06119AB1EF6806" modified="2004-07-05" version="1">MLKLDIAIVVRHPILPARDITLIFDIKAAAEHSVNEVRVSASGKKCGIFRESYVRYDVVPEILKGNNHDIIIHDLNTYFKSKVKDRQKLESFLQSGGNITYEVYLDKIHDENIFELSPWILDECADLGIPLCLSMLMASENIVSKNTDYKALDFITVSIEQPIPNNGVVYYAHEFLLTEDTYLKNEINMAISFYKRHIVDMCLSIKEKVWCKITLCLKTYYHYAFELSSEICKMCAELNIGVMVCF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MG1</accession>
    <name>RNH2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease HII</fullName>
            <shortName evidence="1">RNase HII</shortName>
            <ecNumber evidence="1">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnhB</name>
        <name type="ordered locus">TDE_1547</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972153.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956988.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MG1"/>
    <dbReference type="SMR" id="Q73MG1"/>
    <dbReference type="STRING" id="243275.TDE_1547"/>
    <dbReference type="PRIDE" id="Q73MG1"/>
    <dbReference type="EnsemblBacteria" id="AAS12064">
        <property type="protein sequence ID" value="AAS12064"/>
        <property type="gene ID" value="TDE_1547"/>
    </dbReference>
    <dbReference type="GeneID" id="2740909"/>
    <dbReference type="KEGG" id="tde:TDE_1547"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1483"/>
    <dbReference type="eggNOG" id="COG0164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_3_2_12"/>
    <dbReference type="OMA" id="YPTKLHL"/>
    <dbReference type="OrthoDB" id="1685277at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000235788" description="Ribonuclease HII">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <sequence length="198" mass="22592" checksum="24494570F40A0029" modified="2004-07-05" version="1">MLCGIDEAGRGPLAGPVTAAAVILPSSFDFSILKDSKKLTEKKREEVRKTIYADPNVIWAIGWASNYEIDEINILQATFLAMERAYEGLYLKLQEFCKLNNDKFIEPDIIVDGNFIPNIKNCSSIKALVKADDSVYEVMAASILAKTARDRMMIRYSWIYPEYGYEKHKGYGTKKHIEAIRFNGYSPIQRRSFFVKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MG2</accession>
    <name>Q73MG2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972152.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679203.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1546"/>
    <dbReference type="EnsemblBacteria" id="AAS12063">
        <property type="protein sequence ID" value="AAS12063"/>
        <property type="gene ID" value="TDE_1546"/>
    </dbReference>
    <dbReference type="GeneID" id="2740908"/>
    <dbReference type="KEGG" id="tde:TDE_1546"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1482"/>
    <dbReference type="eggNOG" id="ENOG5030IF3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398439_0_0_12"/>
    <dbReference type="OMA" id="VINDASF"/>
    <dbReference type="OrthoDB" id="491024at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="731" mass="83092" checksum="2F811F20C2C6B042" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MH6</accession>
    <name>Q73MH6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679184.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1532"/>
    <dbReference type="EnsemblBacteria" id="AAS12049">
        <property type="protein sequence ID" value="AAS12049"/>
        <property type="gene ID" value="TDE_1532"/>
    </dbReference>
    <dbReference type="GeneID" id="2740894"/>
    <dbReference type="KEGG" id="tde:TDE_1532"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1469"/>
    <dbReference type="HOGENOM" id="CLU_1433899_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="189" mass="22571" checksum="CE6B6667DEFB32BB" modified="2004-07-05" version="1">MIDDAIYEYLKDCLLFDRCLNLNHSFEWTTEKVEHVKKLGVAIVEKEDLLIKKVKKLAEDYNKLFKETDTGFEDFYIEGCLRLKQNIKLPFASLEDKMRIWYKTFWEDSSVCANTDGLFRDTDDGLFLRDKNWNIERFDKKYVGDTAIPYFLHRIFVDADTYSLEDLMRISPDDFITDIVVIFRNYPDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MI2</accession>
    <name>Q73MI2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972132.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679172.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1526"/>
    <dbReference type="EnsemblBacteria" id="AAS12043">
        <property type="protein sequence ID" value="AAS12043"/>
        <property type="gene ID" value="TDE_1526"/>
    </dbReference>
    <dbReference type="GeneID" id="2739732"/>
    <dbReference type="KEGG" id="tde:TDE_1526"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1463"/>
    <dbReference type="eggNOG" id="ENOG5033F90">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2646854_0_0_12"/>
    <dbReference type="OMA" id="DLIRICP"/>
    <dbReference type="OrthoDB" id="2014162at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="80" mass="9242" checksum="B367D6A3023035EF" modified="2004-07-05" version="1">MPMMLNLEKELIRISPKNGKHIEYSPNQGQTWYLRFQGYQTGVFYDIADGGKELLATTENGLFYSLNRGMTWYKRGGMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MJ9</accession>
    <name>Q73MJ9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein releasing system, ATP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972115.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956980.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1509"/>
    <dbReference type="EnsemblBacteria" id="AAS12026">
        <property type="protein sequence ID" value="AAS12026"/>
        <property type="gene ID" value="TDE_1509"/>
    </dbReference>
    <dbReference type="GeneID" id="2739715"/>
    <dbReference type="KEGG" id="tde:TDE_1509"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1448"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="RMKDFDA"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="221" mass="24561" checksum="B480F2CA3A3FAAF1" modified="2004-07-05" version="1">MLLKTKSLSKSFARGKNSFFAVKDVDFSISASDFVFIVGRSGSGKTTFLNLISGILDPTQGQVFFEDQDISSMNDTDKSFYRNESIGFVPQSLAYLPNLSVFDNVRVPFFLFNRDGDSEGRALSLLDLMDIAHLKNEMPQNLSGGELKRMLIARALMNSPKLLIADEPTANLDKETSETVMNLIKSVNKLGTAVLIVTHDFEILNENSPIYRMNDGELTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MM5</accession>
    <name>Q73MM5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972089.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668962.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1483"/>
    <dbReference type="EnsemblBacteria" id="AAS12000">
        <property type="protein sequence ID" value="AAS12000"/>
        <property type="gene ID" value="TDE_1483"/>
    </dbReference>
    <dbReference type="GeneID" id="2739884"/>
    <dbReference type="KEGG" id="tde:TDE_1483"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1422"/>
    <dbReference type="eggNOG" id="ENOG5031CR7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2686730_0_0_12"/>
    <dbReference type="OMA" id="HRDICEP"/>
    <dbReference type="OrthoDB" id="1905396at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="74" mass="8859" checksum="3EDA71C3418B4D7B" modified="2004-07-05" version="1">MKTLNCDICRKELVNPVTGMTYWHIREYDVCEACKDAIEFKLKPIIRKHFPYSQDWYEHEFIALIEKGVAARRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MP0</accession>
    <name>Q73MP0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoprotease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972074.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679135.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1468"/>
    <dbReference type="EnsemblBacteria" id="AAS11985">
        <property type="protein sequence ID" value="AAS11985"/>
        <property type="gene ID" value="TDE_1468"/>
    </dbReference>
    <dbReference type="GeneID" id="2741583"/>
    <dbReference type="KEGG" id="tde:TDE_1468"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1409"/>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064886_0_0_12"/>
    <dbReference type="OMA" id="GPVYIRK"/>
    <dbReference type="OrthoDB" id="1826274at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="31"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="218" mass="23861" checksum="E0D8C3E7652DBADF" modified="2004-07-05" version="1">MNIVCIDTCFSSVAITAQGNAGTFTSVFTPAKARHSAILIPAIETAVKQAGFSINETDVLVCPQGPGGFTGLRLAYSTAKAIQLQTNARFFCVSILEALCSKYGDKNQFLSVIDAKRDCFYVQAFENKKPISEAFDIRAEDALKLIDKNKKTIICGFGTEKFNEEAGASIESNNITLIEADKETLSKTLLDCFLTNKNCKKVEDHEGPVYIRKSDAEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MP4</accession>
    <name>SSRP_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">smpB</name>
        <name type="ordered locus">TDE_1464</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972070.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668932.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MP4"/>
    <dbReference type="SMR" id="Q73MP4"/>
    <dbReference type="STRING" id="243275.TDE_1464"/>
    <dbReference type="EnsemblBacteria" id="AAS11981">
        <property type="protein sequence ID" value="AAS11981"/>
        <property type="gene ID" value="TDE_1464"/>
    </dbReference>
    <dbReference type="GeneID" id="2741579"/>
    <dbReference type="KEGG" id="tde:TDE_1464"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1405"/>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108953_0_0_12"/>
    <dbReference type="OMA" id="WTNHSAR"/>
    <dbReference type="OrthoDB" id="1720952at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000103058" description="SsrA-binding protein">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <sequence length="154" mass="18167" checksum="3AF4920E906679C6" modified="2004-07-05" version="1">MEKTPVKIIAKNKKAFFNYTVEEKIECGLVLKGTEVKSLREGRISFPDAFAEIKDNEVWVKNFHISEYIYSSVFNHDPERPKKLLLKKDEIKRLKRKVEEKGYTLVPLEFYFKNGIVKVLLGVCKGKKTFDKRADIKDRDIKRDMQREIKIRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MQ4</accession>
    <name>Q73MQ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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        <property type="protein sequence ID" value="AAS11971"/>
        <property type="gene ID" value="TDE_1454"/>
    </dbReference>
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    <dbReference type="KEGG" id="tde:TDE_1454"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1395"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001927">
        <property type="entry name" value="Na/Gal_symport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="PTHR11328"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00792">
        <property type="entry name" value="gph"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="34"/>
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        </location>
    </feature>
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            <end position="129"/>
        </location>
    </feature>
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            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="255"/>
        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="368"/>
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            <end position="426"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AAS11971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MV3</accession>
    <name>Q73MV3_TREDE</name>
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        <submittedName>
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    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1404</name>
    </gene>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678992.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1404"/>
    <dbReference type="EnsemblBacteria" id="AAS11921">
        <property type="protein sequence ID" value="AAS11921"/>
        <property type="gene ID" value="TDE_1404"/>
    </dbReference>
    <dbReference type="GeneID" id="2741271"/>
    <dbReference type="KEGG" id="tde:TDE_1404"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1346"/>
    <dbReference type="eggNOG" id="ENOG5033XG8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_628383_0_0_12"/>
    <dbReference type="OMA" id="NIKYLRP"/>
    <dbReference type="OrthoDB" id="440349at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51781">
        <property type="entry name" value="SH3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284612" evidence="1">
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            <end position="439"/>
        </location>
    </feature>
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            <begin position="104"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="439" mass="49895" checksum="B0654489002801A6" modified="2004-07-05" version="1">MNNFFQKRKLFIFIAVIAASSALFLSSCSKKLGYGVVNWSIPEYNLTAGDIIPVYVKSNIEKVYIVGLNEKTSLRVEIPLWKITFFESKKDAARFQARLSEHKHAYARVKLDGLPMRSNPDNTSNQVYRLKLGQPVKILWFGEGVPVLKGGKPMDGQWYEVITEDGVRGWCFSYNLSIYDERENESSEGTNLAQEKDAELEAVLNEFWYPEHYRKMINNRQVDLDKMSLTWGFFPGLRSGIARVELQNTRLSFPYTKVVKIGNKYLFEGTNLSMQIRGKDIITLEFSDTNGKLRQENFITLNATPENIINNEIKRREAVIQKIAKTSTEFTSENFGSLKILPDGQFIWSGYNLLSPSIIPSGAGSSGKVSLKHFLDKKLLSDYEGVLSFKFEKSPEPVVFMYSISSKGLRLEAVESSSIQDNIVTRRSLDPVILFFAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N12</accession>
    <name>Q73N12_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1344"/>
    <dbReference type="EnsemblBacteria" id="AAS11861">
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        <property type="gene ID" value="TDE_1344"/>
    </dbReference>
    <dbReference type="GeneID" id="2741078"/>
    <dbReference type="KEGG" id="tde:TDE_1344"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1292"/>
    <dbReference type="eggNOG" id="COG5464">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057504_0_2_12"/>
    <dbReference type="OMA" id="YMIYDTV"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="292" mass="34343" checksum="B660D98624DC29F2" modified="2004-07-05" version="1">MQKLFKITLRNDYAFKRVFGVEENKDVLQDLLECILDIPPETIAGLELLDKEFHKELLSEKLGILDIKLRLKDGTFVDIEIQNSWHFDFPERTLYYWSKMYNENIKQGQDYTKLPKCITINLIGKDFDKNKRLHNKYLVLEKDTKEPLVSKLEIHILNLEKAKLLKEAQCKDNKTKRLLNWLKFIETDDREVREMLEQESPMMAKANTAISVMEMSSKDKWLYDSRMKYEHDRASCISEGYRQGLEQGIDRGISQGAYQAKLETAKLMKDMNYPISDICTISGLKKEEIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N14</accession>
    <name>Q73N14_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1342"/>
    <dbReference type="EnsemblBacteria" id="AAS11859">
        <property type="protein sequence ID" value="AAS11859"/>
        <property type="gene ID" value="TDE_1342"/>
    </dbReference>
    <dbReference type="GeneID" id="2741076"/>
    <dbReference type="KEGG" id="tde:TDE_1342"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1290"/>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284966" evidence="1">
        <location>
            <begin position="30"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="679" mass="78574" checksum="5872B93606742277" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N51</accession>
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        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
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    </protein>
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        <name evidence="2" type="ordered locus">TDE_1305</name>
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    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS11822"/>
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    <dbReference type="OrthoDB" id="2072262at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HTH_3"/>
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    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="72" mass="8399" checksum="319D0ACA5F4FDCE8" modified="2004-07-05" version="1">MDWYKEAEKRQTPAKTLRFYRTLNKLTQVQLAEKLGVTKQFISNMETGQKPISRKTAYLLSEIFGIDAGRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NA0</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">TDE_1255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.1207"/>
    <dbReference type="HOGENOM" id="CLU_1239691_0_0_12"/>
    <dbReference type="OrthoDB" id="2126429at2"/>
    <dbReference type="Proteomes" id="UP000008212">
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="226" mass="26332" checksum="277E729306A10293" modified="2004-07-05" version="1">MKKNKILYSIFLVFIAVFSLWGNEGSKLLEDYETVLMRIRYSKTSGFCHDGKTEIREEKVKGSENSFFTEQKNIYLKVKNIKENKVYYTRCFELQEDNGKLAAAANYQIEPAVKITGHWNFFKIGKKLNITVCSGEKCKNTEITLYEINETPKNIKDGIFFEFDESEKKEALNFSISLNAKPMPIIDIKEEEAKMNEILRKMEKYFTAAQIKEKKDVFYKALASLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NG0</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405</strain>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="EnsemblBacteria" id="AAS11074">
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        <property type="gene ID" value="TDE_0579"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11711">
        <property type="protein sequence ID" value="AAS11711"/>
        <property type="gene ID" value="TDE_1193"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0579"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="43" mass="5042" checksum="BBD985B0446E7BD0" modified="2004-07-05" version="1">MLRNLVKANQLNPYRFLILSLPKALRFGYFCSFPSLLISNIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NH3</accession>
    <name>Q73NH3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron compound ABC transporter, permease protein</fullName>
        </submittedName>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971787.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1179"/>
    <dbReference type="EnsemblBacteria" id="AAS11698">
        <property type="protein sequence ID" value="AAS11698"/>
        <property type="gene ID" value="TDE_1179"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1179"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1137"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_1_1_12"/>
    <dbReference type="OMA" id="MQGVFGN"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="325" mass="34405" checksum="65028F5E1757D38C" modified="2004-07-05" version="1">MKKAGVFIVLSLLLIVLFFSSVASGSLKFSFAQIWAALCGRGEQLVTDVIFDLRLPRVLVALVVGMNLASAGALMQAVMQNPLADPGIIGVSAGASVAGVILMLALPQYAYLVPPAAFVGAIFAAFLIYLLAWKDGFTPVRIILSGVAINALLGSLTGLVTILFSDRLQGALMWLNGSLSGKTWRHFQVLIVYSIPALILALLCIRAANVLLLGDEKAKSLGVSVNRCRVFLSIIGAFLAGISTSTVGIIGFIGLVIPHIMRMLVGSDYKSLLPFSMFSGAVLLLGADTFARTIASPIELPVGIVMSIFGAPFFLYLLRSSGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NH5</accession>
    <name>Q73NH5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavodoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971785.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682427.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1177"/>
    <dbReference type="EnsemblBacteria" id="AAS11696">
        <property type="protein sequence ID" value="AAS11696"/>
        <property type="gene ID" value="TDE_1177"/>
    </dbReference>
    <dbReference type="GeneID" id="2740074"/>
    <dbReference type="KEGG" id="tde:TDE_1177"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1135"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098259_1_0_12"/>
    <dbReference type="OMA" id="FFQTHGT"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12641">
        <property type="entry name" value="Flavodoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="167" mass="18829" checksum="C014C942215040D4" modified="2004-07-05" version="1">MKILLTYSSKTGNTKAVAEAVLKTLPQGTDFFAVSEVKDVNNYDAVIVGFWIDKGLPNEEALNFMETIKNKKTGYFFTLGAYPDSPHAEDCHKSAKELLTKNGNEVLAGFGCQGKIDPALTEMFKSLPKDHPHYMNEERRKRHEEAAKHPDKKDFENAKKAFENFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NH8</accession>
    <name>Q73NH8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971782.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670717.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1174"/>
    <dbReference type="EnsemblBacteria" id="AAS11693">
        <property type="protein sequence ID" value="AAS11693"/>
        <property type="gene ID" value="TDE_1174"/>
    </dbReference>
    <dbReference type="GeneID" id="2740071"/>
    <dbReference type="KEGG" id="tde:TDE_1174"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1132"/>
    <dbReference type="eggNOG" id="ENOG50318RT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1115372_0_0_12"/>
    <dbReference type="OMA" id="YKYEISA"/>
    <dbReference type="OrthoDB" id="1242139at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="249" mass="27768" checksum="11C4AA1CE85A8B84" modified="2004-07-05" version="1">MSDDIISELGINASSKDTVELDSLTLEALKKGPIDIFDNVYLGETRPHSLILCIDVRGFSDFMCNNEETVVFGLIKSFTSNFLSCLNQFGYNCSYYKLLGDGALVIWDKLDGVAIKEAVTVFTTYVEFTREELFKPYGNLAIGGALVLDKVYKYEISAEASQLKYRDYVGYGINLACRLQNLAAGGELIVSKKLVDIGAIYATKNTNPEVMKKLRALKGVKPEDREAIFLYKDINPKIISIFKVLSLDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-24" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NW2</accession>
    <name>RS15_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsO</name>
        <name type="ordered locus">TDE_1040</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971648.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671840.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NW2"/>
    <dbReference type="SMR" id="Q73NW2"/>
    <dbReference type="STRING" id="243275.TDE_1040"/>
    <dbReference type="EnsemblBacteria" id="AAS11529">
        <property type="protein sequence ID" value="AAS11529"/>
        <property type="gene ID" value="TDE_1040"/>
    </dbReference>
    <dbReference type="GeneID" id="2741314"/>
    <dbReference type="KEGG" id="tde:TDE_1040"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1000"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148518_0_0_12"/>
    <dbReference type="OMA" id="FKTHVKD"/>
    <dbReference type="OrthoDB" id="1990141at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000115576" description="30S ribosomal protein S15">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <sequence length="89" mass="10197" checksum="34256968E1DB12E8" modified="2004-07-05" version="1">MAVTKEQKASIVKKFGASEKDTGDVKVQIALLTEKINQLTNHCKDHPKDAGSRRGLISMVGHRRSLLKYYRRTDIEGYRTILKELNLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P03</accession>
    <name>Q73P03_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gdhA</name>
        <name evidence="9" type="ordered locus">TDE_0997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971606.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682315.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0997"/>
    <dbReference type="EnsemblBacteria" id="AAS11487">
        <property type="protein sequence ID" value="AAS11487"/>
        <property type="gene ID" value="TDE_0997"/>
    </dbReference>
    <dbReference type="GeneID" id="2739074"/>
    <dbReference type="KEGG" id="tde:TDE_0997"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.958"/>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_1_2_12"/>
    <dbReference type="OMA" id="PCFAAFP"/>
    <dbReference type="OrthoDB" id="1184827at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="180"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="413" mass="45533" checksum="506BEA895151E64F" modified="2004-07-05" version="1">MASTYEKLLTTITEAAKTANLEEDDYISLLSPEREMHVSIPVKMDNGKIKVFSGYRVQHSTLRGPAKGGIRFHQDVNIDEVRSLSAWMTFKCAVADIPYGGGKGGICVNPSNLSETELEKLTRGYTRRITSFIGPKTDIPAPDVGTNAKIMSWIVDSYSSYAGEFTPAVVTGKPLPLGGSKGRVEATGRGVLFATREILKKLNKTLKDQSVVIQGLGNVGGVTADLFYKEEARIIAISDTSSAIYNEKGLDIPQILKHKKGGKKLKSFEGDFKRITNEELLELKADILIPAALENQITEKNASNIKASIIIEAANGPITPEADKILEKKNIITVPDVLANSGGVIVSYFEWVQNLQGFYWTEEEVNKRLEDKMIEAFKLVWDVKEAYKVSMRKAAYIKALKELVETQKVKGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P17</accession>
    <name>Q73P17_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_0982</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971592.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682296.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0982"/>
    <dbReference type="EnsemblBacteria" id="AAS11473">
        <property type="protein sequence ID" value="AAS11473"/>
        <property type="gene ID" value="TDE_0982"/>
    </dbReference>
    <dbReference type="GeneID" id="2740554"/>
    <dbReference type="KEGG" id="tde:TDE_0982"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.944"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_493318_0_0_12"/>
    <dbReference type="OMA" id="MERMTLC"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="331"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="591" mass="63289" checksum="B925971379D5228E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P51</accession>
    <name>Q73P51_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rpn/YhgA-like nuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971558.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682246.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0948"/>
    <dbReference type="EnsemblBacteria" id="AAS11439">
        <property type="protein sequence ID" value="AAS11439"/>
        <property type="gene ID" value="TDE_0948"/>
    </dbReference>
    <dbReference type="GeneID" id="2740981"/>
    <dbReference type="KEGG" id="tde:TDE_0948"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.912"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068216_0_1_12"/>
    <dbReference type="OMA" id="PWPEFIV"/>
    <dbReference type="OrthoDB" id="1105946at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006842">
        <property type="entry name" value="Transposase_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04754">
        <property type="entry name" value="Transposase_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_31" evidence="2">
        <location>
            <begin position="67"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="292" mass="33573" checksum="43CE461A3FFFA7DD" modified="2004-07-05" version="1">MSTSNRKYKDSVFVDLFSEDERAKENFLSLYNALHGTNLPMSCPVENIRLDNVMYMNIINDVSCLVDGKIIILAEHQSTINENMPLRFLEYIARLYEKLQAPTDRYLKKLSKIPTPEFYVFYNGKEDYPETTALKLSDAFITKPKQAPLELTVQVLNINTDKANKILTACKPLEEYSLFVEEVRKQTQLDPENGFTNAIKICIEKGILKEYLMRKSREVINMLVAEYDYDTDIAVQREESLRIGIEQGIRQGFSDGAYQKAIEIAKAFKQFGFDIDKIAEGTGLSREEIEKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P65</accession>
    <name>CH10_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-10</fullName>
            <shortName evidence="1">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groES</name>
        <name evidence="1" type="synonym">groS</name>
        <name type="ordered locus">TDE_0934</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971544.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670325.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73P65"/>
    <dbReference type="SMR" id="Q73P65"/>
    <dbReference type="STRING" id="243275.TDE_0934"/>
    <dbReference type="EnsemblBacteria" id="AAS11425">
        <property type="protein sequence ID" value="AAS11425"/>
        <property type="gene ID" value="TDE_0934"/>
    </dbReference>
    <dbReference type="GeneID" id="2740967"/>
    <dbReference type="KEGG" id="tde:TDE_0934"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.902"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_2_0_12"/>
    <dbReference type="OMA" id="EVKYSGE"/>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000174889" description="Co-chaperonin GroES">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <sequence length="88" mass="9428" checksum="151047EA078CE185" modified="2004-07-05" version="1">MKVKPLGDRVLVKPDAVETKTAGGIIIPDTAQEKTQRGVVVAVGDDKEKIKVSVGQKVIHDKYAGTQIQIDGVDHLILKSNDLVAVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P80</accession>
    <name>Q73P80_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971529.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11410">
        <property type="protein sequence ID" value="AAS11410"/>
        <property type="gene ID" value="TDE_0919"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0919"/>
    <dbReference type="HOGENOM" id="CLU_3391907_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="32" mass="4134" checksum="C31C5786004BA053" modified="2004-07-05" version="1">MYNEPNYKWLESYKIYKQRCEDRTGMYYTEET</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PD8</accession>
    <name>SYY_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="1">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tyrS</name>
        <name type="ordered locus">TDE_0861</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971471.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682133.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PD8"/>
    <dbReference type="SMR" id="Q73PD8"/>
    <dbReference type="STRING" id="243275.TDE_0861"/>
    <dbReference type="EnsemblBacteria" id="AAS11352">
        <property type="protein sequence ID" value="AAS11352"/>
        <property type="gene ID" value="TDE_0861"/>
    </dbReference>
    <dbReference type="GeneID" id="2741372"/>
    <dbReference type="KEGG" id="tde:TDE_0861"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.830"/>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_0_3_12"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="OrthoDB" id="402899at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000234804" description="Tyrosine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="339"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02006"/>
        </source>
    </evidence>
    <sequence length="406" mass="45312" checksum="1452CEC3F5AB008F" modified="2004-07-05" version="1">MNKALKILQERGFIQQCTDLQALSDRMDKGQIAFYTGTDPTGPSLHIGHMVPIFALKHLCREGHKGVVLVGGGTSRIGDPSGKTEMRKMLSYDELDKNAASIQKQIEKFLAKDIKNVRFVNNKDWLADLNYIDFLRDIGSHFSVNKMLSFEAYKKRMETGLSFLEFNYQLLQSYDFLMLNQNYNIELQIGGDDQWGNMVAGSDLIRRKGGGEVFALTFSLVTRADGQKMGKSEKGAIFLDTALVSPYDFFQYWRNTADADVEKFMLLFTFLSIEEIKSVCAGDINKAKERLAFEVTALIHGKEEAEKALEGARAAFSGGGNKDAMPTANLSLSKLNEGIGIIDLFAEAGLASTKSDARRLVEQGGAFINEEKISDIKALIGKEKLDKDNEMILRAGKKRFMRIIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PJ0</accession>
    <name>Q73PJ0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971419.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672157.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0809"/>
    <dbReference type="EnsemblBacteria" id="AAS11300">
        <property type="protein sequence ID" value="AAS11300"/>
        <property type="gene ID" value="TDE_0809"/>
    </dbReference>
    <dbReference type="GeneID" id="2739551"/>
    <dbReference type="KEGG" id="tde:TDE_0809"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.781"/>
    <dbReference type="eggNOG" id="ENOG502Z7N6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059901_0_0_12"/>
    <dbReference type="OMA" id="YKEIDYN"/>
    <dbReference type="OrthoDB" id="394174at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029278">
        <property type="entry name" value="Imm26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15428">
        <property type="entry name" value="Imm26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="381" mass="44196" checksum="2B2F40F620E26AE6" modified="2004-07-05" version="1">MNKQFILTNEQRKYLGLNPIEDHWEVMDIKGTLYYFDGDVIKKEISASDSEGEAFYYRESELDIETAENRTIVLPKTAKGKPKKLNFTATQSFRGIGLYFSFGSRHVCIGNYTTQKTYYSERLEESKASALNSWIEKWIKETSKEDLADLENFKNEKREHQKYKEGDIFAFKIGRRQYGFGKILIDIVKLRKTPEFKKNKNYGLNNLMGTALIVKVYHKISDSINIDLDELEKNLSLPAQPLMDNNIYYGEYKIIGNRKVTYQDLNDAPISTSESINYQDRDIAYLQYGLIYKEMSLKEYALYEDEDWYHKNYRAELIGCFLEIDKLEECIKAKSNAPFYPAAGGSLNNPANKKDKNAIFKAFGLDGDLDYEGNLKLSHEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PL3</accession>
    <name>RL15_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplO</name>
        <name type="ordered locus">TDE_0786</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971396.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682039.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PL3"/>
    <dbReference type="SMR" id="Q73PL3"/>
    <dbReference type="STRING" id="243275.TDE_0786"/>
    <dbReference type="EnsemblBacteria" id="AAS11277">
        <property type="protein sequence ID" value="AAS11277"/>
        <property type="gene ID" value="TDE_0786"/>
    </dbReference>
    <dbReference type="GeneID" id="2740664"/>
    <dbReference type="KEGG" id="tde:TDE_0786"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.759"/>
    <dbReference type="eggNOG" id="COG0200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_4_2_12"/>
    <dbReference type="OMA" id="FKNINRV"/>
    <dbReference type="OrthoDB" id="1874945at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000104847" description="50S ribosomal protein L15">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="150" mass="16256" checksum="21C4A03F470506F7" modified="2004-07-05" version="1">MFEFNLTVPAGATHKKKIVGRGSSSGWGKTSGKGHKGQQARSGGKVYAGFEGGQMPLYRRVAKKGFSNYPFKKEFYVVNLAMLETKYSDGETVNKESLMQKGLLRKGSLYVKVLGTGDITKKLTVDVDRISASAKEKIEKAGGTIVQSEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-02" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PM3</accession>
    <name>RS17_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsQ</name>
        <name type="ordered locus">TDE_0776</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971386.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670009.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PM3"/>
    <dbReference type="SMR" id="Q73PM3"/>
    <dbReference type="STRING" id="243275.TDE_0776"/>
    <dbReference type="EnsemblBacteria" id="AAS11267">
        <property type="protein sequence ID" value="AAS11267"/>
        <property type="gene ID" value="TDE_0776"/>
    </dbReference>
    <dbReference type="GeneID" id="2740654"/>
    <dbReference type="KEGG" id="tde:TDE_0776"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.749"/>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_0_12"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="OrthoDB" id="2035880at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000233599" description="30S ribosomal protein S17">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <sequence length="90" mass="10473" checksum="9C92514E3E685E4A" modified="2004-07-05" version="1">METTENTKKIGKREFVGIVTSDKMNKTIVVEVRTKKLHKLYKKYVSSSKKYKAHDEENTAHIGDTVRIVEHKPISKDKAWMLTEVIERAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PN0</accession>
    <name>RL23_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplW</name>
        <name type="ordered locus">TDE_0769</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971379.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672216.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PN0"/>
    <dbReference type="SMR" id="Q73PN0"/>
    <dbReference type="STRING" id="243275.TDE_0769"/>
    <dbReference type="EnsemblBacteria" id="AAS11260">
        <property type="protein sequence ID" value="AAS11260"/>
        <property type="gene ID" value="TDE_0769"/>
    </dbReference>
    <dbReference type="GeneID" id="2740309"/>
    <dbReference type="KEGG" id="tde:TDE_0769"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.742"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_3_2_12"/>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="OrthoDB" id="1978865at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000272866" description="50S ribosomal protein L23">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <sequence length="94" mass="10717" checksum="2FBE4163B21DDE4D" modified="2004-07-05" version="1">MEYNDILIAPVLTEKSTELREQGKYVFKVAPKATKIQIKEAVRRLFNVKVTDCTVVNVRGKTKRLRYKEGKTSSWKKATVKLAKGETIKIFEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PP4</accession>
    <name>Q73PP4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971364.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672235.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0753"/>
    <dbReference type="EnsemblBacteria" id="AAS11245">
        <property type="protein sequence ID" value="AAS11245"/>
        <property type="gene ID" value="TDE_0753"/>
    </dbReference>
    <dbReference type="GeneID" id="2739872"/>
    <dbReference type="KEGG" id="tde:TDE_0753"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.728"/>
    <dbReference type="HOGENOM" id="CLU_1293872_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284623" evidence="1">
        <location>
            <begin position="29"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="212" mass="24682" checksum="8D8B39B5CBE54057" modified="2004-07-05" version="1">MIKFKLNKKYIFLLLSLSLVLFSSCSSIGGYVNGKTLNKKEFGPPETHTLMFGHMDVEDAPLHLPVNNTAKDYQEYIQMNPEKEPLIFLPIYFQGSVMSFYPMEPGVNLRLMFSRYSIMRFYGNYTHTTVYQFWPFLGWPESSTLWFSCKKPGLQYIGSYIRTKSGYKKDMEKDSAKNELSALEGIKAYYKGTSWETVIEKRIEELQNEKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PR1</accession>
    <name>Q73PR1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971347.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681987.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0736"/>
    <dbReference type="EnsemblBacteria" id="AAS11228">
        <property type="protein sequence ID" value="AAS11228"/>
        <property type="gene ID" value="TDE_0736"/>
    </dbReference>
    <dbReference type="GeneID" id="2740290"/>
    <dbReference type="KEGG" id="tde:TDE_0736"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.713"/>
    <dbReference type="eggNOG" id="ENOG5031CW9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192351_0_0_12"/>
    <dbReference type="OrthoDB" id="2057861at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038733">
        <property type="entry name" value="Predicted_DNA_bind_prot_RHH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12651">
        <property type="entry name" value="RHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_3" evidence="1">
        <location>
            <begin position="3"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="76" mass="8715" checksum="E8D564CCFD857C1E" modified="2004-07-05" version="1">MPTMTMTNKLYQELEQAAQMTRVAKDTILENALSRYLAELKEDAEDAVCAEKAWNDFEKSGKKTYTIAEMRHELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q44</accession>
    <name>Q73Q44_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971214.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681774.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0600"/>
    <dbReference type="EnsemblBacteria" id="AAS11095">
        <property type="protein sequence ID" value="AAS11095"/>
        <property type="gene ID" value="TDE_0600"/>
    </dbReference>
    <dbReference type="GeneID" id="2741563"/>
    <dbReference type="KEGG" id="tde:TDE_0600"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.580"/>
    <dbReference type="eggNOG" id="ENOG5031CQI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2738853_0_0_12"/>
    <dbReference type="OrthoDB" id="1957129at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="71" mass="8349" checksum="8B3B0627BF8D05C8" modified="2004-07-05" version="1">MSELAFEQLSAQVDMLSYTERLRLLDKIVKTLHKPVKTHKREDSDFNAAFGLWKDRNISVEEIRNKAWGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q46</accession>
    <name>Q73Q46_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabG</name>
        <name evidence="4" type="ordered locus">TDE_0598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971212.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681771.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0598"/>
    <dbReference type="EnsemblBacteria" id="AAS11093">
        <property type="protein sequence ID" value="AAS11093"/>
        <property type="gene ID" value="TDE_0598"/>
    </dbReference>
    <dbReference type="GeneID" id="2741561"/>
    <dbReference type="KEGG" id="tde:TDE_0598"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.578"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_12"/>
    <dbReference type="OMA" id="KMPERDY"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="155"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="247" mass="26142" checksum="D195514FF34506A7" modified="2004-07-05" version="1">MLLKGKKALVTGSSRGIGKEVVRRFIEEGAEVWGLCTKPSASKAEMEAFAKEKGSTFHEIYADCGNAEGLTETVKKALEESGGFDILVNNAGITRDGLSFRMKLSDWEDVLRVNLTGVFVASQIVSSDMIRKRAGSIINMTSIVGLHGQGGQVNYSASKAGLIGFTKSLAKETAGRGVRVNAIAPGYIETDMTAAVNEEMRKAWIEGIPLKRAGLPLDIANAAVFLASDLSLYITAQVLGVDGGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q99</accession>
    <name>Q73Q99_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971158.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0544"/>
    <dbReference type="EnsemblBacteria" id="AAS11039">
        <property type="protein sequence ID" value="AAS11039"/>
        <property type="gene ID" value="TDE_0544"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0544"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.529"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_1_0_12"/>
    <dbReference type="OMA" id="DYAAHAN"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="310" mass="34440" checksum="37016407C85BA676" modified="2004-07-05" version="1">MTGGSAGVNAENAGMLPTGKTYTVNGVSFTMIAIPAVTDGTLGYGEYDVNPAHTVSLPAYRIGETEVTQELWQAVMGNNPSGFNGNDEETKPAGGEEQKKRPIEMINWYQAIAFCNKLSLKLGLEPCYTVTVKGKPIDFASLPFDKIPSEDEYMPQKDRIIKAWDAVTVDISKNGFRLPSEAEWEWAAKGGVESRWAGSDDEEEVDRYMWHDGNSENRTHEVKKLKPNGYGLYDMSGNVWEWCWDRFKDFLPDSLVEAGVVDIDDIPDSCRVFRGGGIDIDIYNAALPIRLFYTPDFHAGSLGLRLACRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QA9</accession>
    <name>Q73QA9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971148.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681676.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0534"/>
    <dbReference type="EnsemblBacteria" id="AAS11029">
        <property type="protein sequence ID" value="AAS11029"/>
        <property type="gene ID" value="TDE_0534"/>
    </dbReference>
    <dbReference type="GeneID" id="2741753"/>
    <dbReference type="KEGG" id="tde:TDE_0534"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.520"/>
    <dbReference type="eggNOG" id="ENOG502Z93U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101742_0_0_12"/>
    <dbReference type="OMA" id="LAYHYEL"/>
    <dbReference type="OrthoDB" id="1215041at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="263" mass="29965" checksum="FAAE74C90D619931" modified="2004-07-05" version="1">MPNSTEKILQELEAERLRRQNLTKEDLQKKYAKLQRAGFPLSECIGFIADLGGSNQLAYHYELICKDWERDDPLHLDNSFDKHDLAGIDFLFAAINKASTEKIRVFTAYLIAEILVRSKHRDFYTAACNRLVPILVSHINTKDCVLRRKVLIAVGWVGAVQEIGIFNERMLHDEDSLCRAWSASGLMQLSFNRLNTQTILLEVKDVFRQAIAVEKDLFACGVMIESAQSLFGKKWISSIAVENKDSVKIEKARKSAVRFLSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QE4</accession>
    <name>Q73QE4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971113.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681622.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0499"/>
    <dbReference type="EnsemblBacteria" id="AAS10994">
        <property type="protein sequence ID" value="AAS10994"/>
        <property type="gene ID" value="TDE_0499"/>
    </dbReference>
    <dbReference type="GeneID" id="2738984"/>
    <dbReference type="KEGG" id="tde:TDE_0499"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.485"/>
    <dbReference type="eggNOG" id="COG4927">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074093_0_0_12"/>
    <dbReference type="OMA" id="FCSTHVE"/>
    <dbReference type="OrthoDB" id="1339204at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="326" mass="38146" checksum="E9708CEA8F532DAB" modified="2004-07-05" version="1">MYHSRWKNNHYSAGFSYGSRLYKNNVKIDFAKFLTNEKMKYGKEVFSIYHEYYSEIIEEIQGFADGQNYDFDKVFSFLVGMYVFTYDTHCSMIAFSNSNGIYFARNSDFMIEVEKLSDSAYYKLNKGYSFIGNTTAMIEMEDGINEKGLACGLTFVYPTVKDVGFNAGFLVRYILEKCETIEEVKSFLKKIPIGSSQNIIAIDRYGTVLSAELNARCQDIKIGNRALKTNHFVSNKLKSYKYDGKDDIYSHERYKTLESQKFEEYTLDNVFALMRGERGFLCQYNRKNGFDTIWSSVYDIKNKVIYRCEGNPDRKKYQIDKRMRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QQ0</accession>
    <name>Q73QQ0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971007.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676749.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0393"/>
    <dbReference type="EnsemblBacteria" id="AAS10888">
        <property type="protein sequence ID" value="AAS10888"/>
        <property type="gene ID" value="TDE_0393"/>
    </dbReference>
    <dbReference type="GeneID" id="2739402"/>
    <dbReference type="KEGG" id="tde:TDE_0393"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.382"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1260423_0_0_12"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="215" mass="25996" checksum="C883F281FC96D920" modified="2004-07-05" version="1">MPKSTFLKLSDERKEKLRKTIYNMFIKKDYESISIRDLVKEMDISIGSFYKYFDDKAEMYLFFFSEIEKKIFEEEKRRNASFFYPAKLLDLHEILTQEEIDFSTSWLNVPEDVLYKFYFRGHAKQLYRSILDELTEMQQKAQLNPNIKANIAYHIIITSMFSFMLYIKENKITDKEDFFSRKTTYYQTVILPGILSEKYYKQKYSKNAIKSEIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QQ9</accession>
    <name>Q73QQ9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970998.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681409.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0384"/>
    <dbReference type="EnsemblBacteria" id="AAS10879">
        <property type="protein sequence ID" value="AAS10879"/>
        <property type="gene ID" value="TDE_0384"/>
    </dbReference>
    <dbReference type="GeneID" id="2740316"/>
    <dbReference type="KEGG" id="tde:TDE_0384"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.373"/>
    <dbReference type="eggNOG" id="ENOG502ZF8H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125506_0_0_12"/>
    <dbReference type="OrthoDB" id="1789901at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="185" mass="21621" checksum="DCB2371B1F152D36" modified="2004-07-05" version="1">MIVKAIELRNKENLQKIKKVPGYYKWWAKRTELDIILTELNVKFDDVKSSIETKSGMFCIYVGIAVKESIRDRLNWHVNDKHTESSVKYGTLSTLRQSIASIVAHNQYDKEATDNFIDKLEVEYFFNDNPIKSTDAKNELTDIEKQLLQEHLRVLNIRDNNHPCAKEIKKELKRLRKISKNTAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QR4</accession>
    <name>Q73QR4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970993.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681400.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0379"/>
    <dbReference type="EnsemblBacteria" id="AAS10874">
        <property type="protein sequence ID" value="AAS10874"/>
        <property type="gene ID" value="TDE_0379"/>
    </dbReference>
    <dbReference type="GeneID" id="2739472"/>
    <dbReference type="KEGG" id="tde:TDE_0379"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.368"/>
    <dbReference type="eggNOG" id="ENOG5031CGK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_997272_0_0_12"/>
    <dbReference type="OrthoDB" id="2063396at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="279" mass="32425" checksum="F679162553E6FCEC" modified="2004-07-05" version="1">MKKGITVILVYCLLLLVCTSCASLGIWMHGEQYFVGKTENDLIKYFGDHGVELSNKTEYDKVIRFCNQIDTLYMDKTTVNMYKKGTPQCVFSLDFVEYNDGCLVLNGRSHYSGGTSSFGKVIMPRHSNDNAIIKNELNRFWYEVKRLKAVSTSEQDARFNNTPVGSWYFMYTKSSEYIYHGGNPYVKEPPSNIPFYHYNIWRVDVSSTQKATTETEIAYVFDLKHLTYYDAKGRQISLSQALENEKYYEKQGYTRRLTKEGMTVDAYIKYNKIVKIEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QR7</accession>
    <name>Q73QR7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970990.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681397.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0376"/>
    <dbReference type="EnsemblBacteria" id="AAS10871">
        <property type="protein sequence ID" value="AAS10871"/>
        <property type="gene ID" value="TDE_0376"/>
    </dbReference>
    <dbReference type="GeneID" id="2739469"/>
    <dbReference type="KEGG" id="tde:TDE_0376"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.366"/>
    <dbReference type="eggNOG" id="COG1178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_1_1_12"/>
    <dbReference type="OMA" id="VGQQQFG"/>
    <dbReference type="OrthoDB" id="1783638at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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    </dbReference>
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        <location>
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            <end position="37"/>
        </location>
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            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="513"/>
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        </location>
    </feature>
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    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="342"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS10871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="539" mass="59614" checksum="84214CB708E6107B" modified="2004-07-05" version="1"> </sequence>
</entry>
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    <accession>Q73QZ0</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">TDE_0303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS10798">
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        <property type="gene ID" value="TDE_0303"/>
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    <dbReference type="OrthoDB" id="2028198at2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006156-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="93" mass="10775" checksum="DF51F53AE340E027" modified="2004-07-05" version="1">MIYQLKKTSQFKASVKLAKKRGLNINLLEGIIEKLRTDTPLGVKHKNHQLSGQFKGIWECHIQPDWLLLYLKEENNLVMTLVDTGTHSDIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QZ1</accession>
    <name>Q73QZ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelB/DinJ antitoxin family.</text>
    </comment>
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        <property type="protein sequence ID" value="AAS10797.1"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676649.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0302"/>
    <dbReference type="EnsemblBacteria" id="AAS10797">
        <property type="protein sequence ID" value="AAS10797"/>
        <property type="gene ID" value="TDE_0302"/>
    </dbReference>
    <dbReference type="GeneID" id="2740289"/>
    <dbReference type="KEGG" id="tde:TDE_0302"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.290"/>
    <dbReference type="eggNOG" id="COG3077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154558_5_3_12"/>
    <dbReference type="OMA" id="EARQISC"/>
    <dbReference type="OrthoDB" id="2086657at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015643">
        <property type="term" value="F:toxic substance binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
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        <property type="entry name" value="DinJ"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02384">
        <property type="entry name" value="RelB_DinJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="92" mass="10224" checksum="E64223176346E1AF" modified="2004-07-05" version="1">MSTAVLQTRVDSQIKKEADDLFNALGIDTTTAIRLFLKQAINQQKIPFEILPPQKEFSPSVLAAIKEARQISCDASVKQYKTAKELLADCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R31</accession>
    <name>Q73R31_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavodoxin_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970876.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681191.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="protein sequence ID" value="AAS10757"/>
        <property type="gene ID" value="TDE_0261"/>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.256"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_105338_0_0_12"/>
    <dbReference type="OMA" id="CRGWDTN"/>
    <dbReference type="OrthoDB" id="796211at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
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    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin_5" evidence="1">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="152" mass="16970" checksum="318568126F8CAF24" modified="2004-07-05" version="1">MSNVCIVYSSTHHGNTEKVLNKIKEKFPETVLIKAGDFNPDDFNRYEAIGFASGIFYFKFAKPVDKLFEQALVGSVQKLFFIYTAGAVNAGFEKTLRKKTEQSGKICMGIFGCKGFDTFGPLKLIGGLNKNSPNEKDFKNAIDFFEKNIINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RA8</accession>
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        <submittedName>
            <fullName evidence="6">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="EnsemblBacteria" id="AAS10680">
        <property type="protein sequence ID" value="AAS10680"/>
        <property type="gene ID" value="TDE_0183"/>
    </dbReference>
    <dbReference type="GeneID" id="2741608"/>
    <dbReference type="KEGG" id="tde:TDE_0183"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.179"/>
    <dbReference type="eggNOG" id="COG1178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021838_2_2_12"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
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        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="458"/>
        </location>
    </feature>
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        <location>
            <begin position="464"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="523"/>
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        </location>
    </feature>
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        <location>
            <begin position="566"/>
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        </location>
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        <location>
            <begin position="89"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="399"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="602" mass="66891" checksum="6DA699CC1598226A" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RB5</accession>
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        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">TDE_0176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970792.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681059.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0176"/>
    <dbReference type="EnsemblBacteria" id="AAS10673">
        <property type="protein sequence ID" value="AAS10673"/>
        <property type="gene ID" value="TDE_0176"/>
    </dbReference>
    <dbReference type="GeneID" id="2739349"/>
    <dbReference type="KEGG" id="tde:TDE_0176"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.173"/>
    <dbReference type="eggNOG" id="COG3817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078249_0_0_12"/>
    <dbReference type="OMA" id="CWLTRDT"/>
    <dbReference type="OrthoDB" id="1538718at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009323">
        <property type="entry name" value="DUF979"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06166">
        <property type="entry name" value="DUF979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
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        <location>
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            <end position="58"/>
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    </feature>
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        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="126"/>
        </location>
    </feature>
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        <location>
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        <location>
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        </location>
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        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
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        <location>
            <begin position="269"/>
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        </location>
    </feature>
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        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS10673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="332" mass="34869" checksum="76EE9CCE72A76F56" modified="2004-07-05" version="1">MFSFIHNNTMVIDEIVYGLCGLVSIITAVISLKDKKNPIGTFLFWGILGLLFMFGKVIVLNVPYGGAIIGGLLIVLGGFTLTKQVKVADIKSATKEEITENSKKVGNKIFIPAVLIGVVAMLLAQMKSFKISLGTNAAGKEIIFGFSTAQVVGLASIVALIFAIFLTKPKMKNTINDTSKMLMQVGSSSLLPQLLGVLGAIFATAGIGKIIGHFASGIVPQGVPVLGVIAYCLGMVIFTMIMGNAFAAFTVITIGVGVPFVIAQGGNPAVVGALGMTCGYCGTLLTPMAANFNIVPAAILETKNKYTLIKAQALMSFALIIVHIILMLIFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RC6</accession>
    <name>Q73RC6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970780.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0164"/>
    <dbReference type="EnsemblBacteria" id="AAS10661">
        <property type="protein sequence ID" value="AAS10661"/>
        <property type="gene ID" value="TDE_0164"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0164"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.161"/>
    <dbReference type="eggNOG" id="ENOG5032SGE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080981_1_0_12"/>
    <dbReference type="OMA" id="RRSCGRN"/>
    <dbReference type="OrthoDB" id="1721190at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024523">
        <property type="entry name" value="DUF3793"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12672">
        <property type="entry name" value="DUF3793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="193" mass="22141" checksum="69925F5F7C52E690" modified="2004-07-05" version="1">MSIANIEYNLAYSCAPCLAGIKPSNLFSISAEDFKQFFLLDKDLLEAKGFFLKVLCACERGVQILLYKKDSLETLIKDERVQAALLMFGYEPGMSLEDMLNLLASRMHSSQADRHCKRCCSFPHEIGLFLGYPVYDVLEYYRRNGEGCIFSGYWKVYSDAEKAAEIFNRYNECKKHFALQIEKGLRLYDLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RF8</accession>
    <name>Q73RF8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970748.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0131"/>
    <dbReference type="EnsemblBacteria" id="AAS10629">
        <property type="protein sequence ID" value="AAS10629"/>
        <property type="gene ID" value="TDE_0131"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0131"/>
    <dbReference type="HOGENOM" id="CLU_3405966_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3310" checksum="27EB67CFC4C4CC73" modified="2004-07-05" version="1">MTINIDDKVLDYLKKINSKAITIDLIGCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RK5</accession>
    <name>Q73RK5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">engA</name>
        <name evidence="7" type="synonym">der</name>
        <name evidence="12" type="ordered locus">TDE_0083</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970700.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680939.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0083"/>
    <dbReference type="EnsemblBacteria" id="AAS10581">
        <property type="protein sequence ID" value="AAS10581"/>
        <property type="gene ID" value="TDE_0083"/>
    </dbReference>
    <dbReference type="GeneID" id="2741698"/>
    <dbReference type="KEGG" id="tde:TDE_0083"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.84"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016077_6_1_12"/>
    <dbReference type="OMA" id="KFRFLEY"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="11">
        <location>
            <begin position="209"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="84"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="215"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="262"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="327"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS10581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="476" mass="53647" checksum="C6648BDA2D9A0304" modified="2004-07-05" version="1">MPKTKDEIIDEENISPDSSEFSHQKKYKNIPLIAIVGRPNVGKSTLFNRFLRKRRSITDPTPGVTRDPVEAQAIINGLPVMLVDTGGFKLTRSGDAFEDTIDELVMEKTISTLKKADRILLLLDAGLATAEDEEFIQFLRPYFNKLVVAVNKTEGGRLMAEACNYYSYGFKSLTCISAEHGDNISELAEELTAGLDFSKVEELEEDDTIRITIVGKPNTGKSTLANYLTGSSASIISNVAGTTRDIVEGEFSYKNKKFLIQDTAGIRRKAKVNEDIEYYSVVRAIKSMDNADIVFHLIDVQEGLTEQDKKIIVQATNRGLGVIFVLNKWDLMEQTKKAFKDEEERIKVMFGKMDYAPVLAISANEGTGIKELLNTAVKMFEQLNKKIETSALNIALKDWLQAAPPPQGRQTAFTFRYIVQTGSRPAEFLLFSNRPDYVTESYMRYIQNKIRSDLGFEMIPILLKVKGSRKRWEERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RK8</accession>
    <name>Q73RK8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Betaine aldehyde dehydrogenase</fullName>
            <ecNumber evidence="5">1.2.1.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gbsA</name>
        <name evidence="5" type="ordered locus">TDE_0080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970697.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680934.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0080"/>
    <dbReference type="EnsemblBacteria" id="AAS10578">
        <property type="protein sequence ID" value="AAS10578"/>
        <property type="gene ID" value="TDE_0080"/>
    </dbReference>
    <dbReference type="GeneID" id="2741695"/>
    <dbReference type="KEGG" id="tde:TDE_0080"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.81"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_2_12"/>
    <dbReference type="OMA" id="HGIGYYP"/>
    <dbReference type="OrthoDB" id="744602at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008802">
        <property type="term" value="F:betaine-aldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="22"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="494" mass="54177" checksum="6B8432A4A1145289" modified="2004-07-05" version="1">METLKYVKKEPYQLFIDGKYIPSENGSIVDVINPVNNLPFAKAYRGTKTDCEKAIAAARKAFDEGPYRKMSAKDRSKLLLKAAQILERRAEELAVIETLECGKNYSACRYWEVPMAIDSFEFFAGKARCLDGKVVPSEYGTLNYVTWNPCGVVGEILPWNGPFLMGCQKVNAILAAGNTVVIKPPSWGVLSMILMASIYEEAGFPSGVVNVVTGSGAEVGNCLVESELVDMVSMTGGVETGREIIAHSAKLVKDIALELGGKSPNIFFEDVDIEQAARFAVYGFTNHAGQICVSGTRILVQRRIYEPFIKAMVETAYKLKPGDGFDPSTTINTLISREHANTVWEYIEKGKKQNARLVCGGNPYSEPLLKKGNFIPPTIFADVTPEMEIFQNEIFGPVACITPFDTEEEAISLANATKYGLAGGVFTKDIKRAIRVADRINSGQIYINNYFSKGMIESPGTGWKESGIGIAGIHKYMISKTVFVETVDNVLLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RN0</accession>
    <name>Q73RN0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970675.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0058"/>
    <dbReference type="EnsemblBacteria" id="AAS10556">
        <property type="protein sequence ID" value="AAS10556"/>
        <property type="gene ID" value="TDE_0058"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0058"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.60"/>
    <dbReference type="eggNOG" id="COG3708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_81_11_12"/>
    <dbReference type="OrthoDB" id="1748122at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010499">
        <property type="entry name" value="AraC_E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029442">
        <property type="entry name" value="GyrI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06445">
        <property type="entry name" value="GyrI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00871">
        <property type="entry name" value="AraC_E_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="SSF55136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AraC_E_bind" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="110" mass="12706" checksum="895D7B74A2BE25E0" modified="2004-07-05" version="1">MGNGQSYGSCYEVKDCNSFNYMAGYDCTDEQKAETFGLSVMHIPEAEYAVVQLKGPVPDCIHQGWKYVMDTFFPEQGYRHAGTPDFEIYKEGDMYDKNYNMELWVPIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RS3</accession>
    <name>Q73RS3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbon starvation protein CstA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_0012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970629.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666927.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0012"/>
    <dbReference type="EnsemblBacteria" id="AAS10510">
        <property type="protein sequence ID" value="AAS10510"/>
        <property type="gene ID" value="TDE_0012"/>
    </dbReference>
    <dbReference type="GeneID" id="2741627"/>
    <dbReference type="KEGG" id="tde:TDE_0012"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.14"/>
    <dbReference type="eggNOG" id="COG1966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010531_3_1_12"/>
    <dbReference type="OMA" id="MLAESFV"/>
    <dbReference type="OrthoDB" id="457782at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="9">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="9">
        <location>
            <begin position="156"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="10">
        <location>
            <begin position="323"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS10510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="484" mass="52025" checksum="9819CCF1229090CD" modified="2004-07-05" version="1">MITFFICLAILIVGHFVYGKYVQKVFGISSAPTPAISKQDGVDYVPLSTGRVFLIQLLNIAGLGPIFGAISGALWGASAFFWIGLGTIFAGGVHDYLSGMISERHDGASISELSGVYLGPIMKFIMRVFAVVLLIFVGTVFMKGPADLLAKLTPEKFGSNFWLIIVLAYYFLATILPVDKIIGKIYPVFGIVLIIMALGIGAGILFNAFRGTMTIPEFSLANVHPSNLPRWPLLFITIACGAISGFHATQSPLMARCIKSEADGHKVFYGAMVGEGIIALVWAAAGMTFYYGTGGLQEALNTLGGPAGVVYDISFKLLGGIGGFLAVLGVIACPITSGDTAFRSARLTLADWFKVDQKPINKRLLLAIPLLAIGGLLSQINFNIIWRYFAWSNQTLAMIALWVGAMYLFLNKKNFIIALVPATFMTAVSVTYILMAPEGFKLDKMISYPIGIAAALICLGAFIFVIMRKKKNGTDVPPIPAPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q73IZ6</accession>
    <name>Q73IZ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2781</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973379.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666962.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2781"/>
    <dbReference type="EnsemblBacteria" id="AAS13298">
        <property type="protein sequence ID" value="AAS13298"/>
        <property type="gene ID" value="TDE_2781"/>
    </dbReference>
    <dbReference type="GeneID" id="2739170"/>
    <dbReference type="KEGG" id="tde:TDE_2781"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2624"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OMA" id="AQFLNFA"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="35"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="361"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="394"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS13298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="609" mass="67509" checksum="E43C7CE759957D28" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J35</accession>
    <name>Q73J35_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973339.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680802.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2741"/>
    <dbReference type="EnsemblBacteria" id="AAS13258">
        <property type="protein sequence ID" value="AAS13258"/>
        <property type="gene ID" value="TDE_2741"/>
    </dbReference>
    <dbReference type="GeneID" id="2740960"/>
    <dbReference type="KEGG" id="tde:TDE_2741"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2587"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071021_0_0_12"/>
    <dbReference type="OMA" id="PNDNQGL"/>
    <dbReference type="OrthoDB" id="1675321at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="259" mass="30748" checksum="E50149739EE7D5A6" modified="2004-07-05" version="1">MTDILDFPDFPFEFEQNNEQKAQDIVYDAWDSDSSAQRKRLAQKALELDPNCVDAYCILAAEYTSYKKKNEYYKKGIEVFRKKYGEKFFSENRGDFWEIFETRPFMRLSAGYGQLLWNNEKKDEAVQIYEELLQLNPNDNQGLRYTLINWFIDQNQLDKVTELLKEYQEGTAFMLFSDLLLSIKKQESDTKILKKYIKAKNANPYVVKYLLKENELPEYLPDYYGFGDENEAVTYCFGSMDVWLKDQDTIKKLKEISDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JC3</accession>
    <name>Q73JC3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973250.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680697.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2652"/>
    <dbReference type="EnsemblBacteria" id="AAS13169">
        <property type="protein sequence ID" value="AAS13169"/>
        <property type="gene ID" value="TDE_2652"/>
    </dbReference>
    <dbReference type="GeneID" id="2741097"/>
    <dbReference type="KEGG" id="tde:TDE_2652"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2507"/>
    <dbReference type="eggNOG" id="COG4587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084465_0_0_12"/>
    <dbReference type="OMA" id="YLIDFPA"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010390">
        <property type="entry name" value="DUF990"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06182">
        <property type="entry name" value="ABC2_membrane_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="251" mass="29296" checksum="5D726DCBB713011C" modified="2004-07-05" version="1">MKYLLGIISLNIKQHLYFKISAVFSIFSLLFLFLIKSSVWSQIGNTDYISYFAIITIVGSFISVNTDRYFQTIYQTGSISFLLLRPINFGINIFLQDSAAALTRFILKSLPLLIVLILFFDVNIYHGIINLCLFIFSVFCAYLFNWFTAYIIGLCVFFYGNNEGFIQIKNILFLFFSGSLIPVDFFPEVLQKILNYLPFRILYQIPIEVLNNSNLKSFSLISRQLYWIFFLLVFTYIFHRRAIKKIEIMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JC5</accession>
    <name>Q73JC5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973248.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957285.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2650"/>
    <dbReference type="EnsemblBacteria" id="AAS13167">
        <property type="protein sequence ID" value="AAS13167"/>
        <property type="gene ID" value="TDE_2650"/>
    </dbReference>
    <dbReference type="GeneID" id="2741095"/>
    <dbReference type="KEGG" id="tde:TDE_2650"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2505"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_10_4_12"/>
    <dbReference type="OMA" id="IFEMFSI"/>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="121" mass="13796" checksum="B966EC8D48E5EB5A" modified="2004-07-05" version="1">MNIFLNNSSGVPLYEQLSEQIKNQILSGSLKKEEPMPSMRALAASLRVSVITTKRSYEDLAREGFLYSVSAKGYFVADVNFKKIEKSIKKSIEEKLKEVCGQAKKINLNAEDLYEILRRIY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JG6</accession>
    <name>RIMO_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="1">S12 MTTase</shortName>
            <shortName evidence="1">S12 methylthiotransferase</shortName>
            <ecNumber evidence="1">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimO</name>
        <name type="ordered locus">TDE_2609</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973207.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680609.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JG6"/>
    <dbReference type="SMR" id="Q73JG6"/>
    <dbReference type="STRING" id="243275.TDE_2609"/>
    <dbReference type="EnsemblBacteria" id="AAS13126">
        <property type="protein sequence ID" value="AAS13126"/>
        <property type="gene ID" value="TDE_2609"/>
    </dbReference>
    <dbReference type="GeneID" id="2740783"/>
    <dbReference type="KEGG" id="tde:TDE_2609"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2467"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_0_1_12"/>
    <dbReference type="OMA" id="HYAYPTG"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000375059" description="Ribosomal protein S12 methylthiotransferase RimO">
        <location>
            <begin position="1"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="139"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="389"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="467" mass="52131" checksum="32DF86AD328AEB72" modified="2004-07-05" version="1">MDLHGCAKNQVDAELIIGIMENLSWKNTSDPDEADLIIVNSCGFINSAKEESINAVLQAKAAHPKAKVLLAGCLAERYADILKNDLPEADGIFGNGNLSLLPQLIDSMFPKKTSDEKFIEKTLVPPQIGICGGERPKILNFPRSTYIKITEGCDNFCSFCAIPIIRGRLRSRPIKDICDEIKTFLKKSFYEFNLIGQDLAAYQTGKDDLSEDELHRENCSGLALLLKSISKIKGNFKIRLLYIHPDHFPLDILPIMTADKRFLPYFDIPFQSGAQKIIRAMNRNGAAEVYLDIIKNIREAFEKTNSPYGEPQIRTTFLVGFPGETDEDFNETIKFLKELRPLWSGGFTYSREEDTPSYSFKGKVPKKTAEARLAEIQNAQTSITEKKLDSFIGKEIEVLVEELIQAEDKTFLALGRAWFQAPEVDGAVVLNFNLNKKDIDGNPIAPGSIVKARIAARNGFDLEAVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JG9</accession>
    <name>Q73JG9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Urocanate hydratase</fullName>
            <shortName evidence="9">Urocanase</shortName>
            <ecNumber evidence="4 9">4.2.1.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Imidazolonepropionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">hutU</name>
        <name evidence="13" type="ordered locus">TDE_2606</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-imidazolone-5-propanoate = H2O + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:13101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="4.2.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the urocanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.49" evidence="4 9"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973204.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680599.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2606"/>
    <dbReference type="EnsemblBacteria" id="AAS13123">
        <property type="protein sequence ID" value="AAS13123"/>
        <property type="gene ID" value="TDE_2606"/>
    </dbReference>
    <dbReference type="GeneID" id="2741310"/>
    <dbReference type="KEGG" id="tde:TDE_2606"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2464"/>
    <dbReference type="eggNOG" id="COG2987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018868_3_0_12"/>
    <dbReference type="OMA" id="LVGDWAN"/>
    <dbReference type="OrthoDB" id="100619at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00550"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016153">
        <property type="term" value="F:urocanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00577">
        <property type="entry name" value="HutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023637">
        <property type="entry name" value="Urocanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035401">
        <property type="entry name" value="Urocanase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038364">
        <property type="entry name" value="Urocanase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023636">
        <property type="entry name" value="Urocanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035400">
        <property type="entry name" value="Urocanase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035085">
        <property type="entry name" value="Urocanase_Rossmann-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036190">
        <property type="entry name" value="Urocanase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12216">
        <property type="entry name" value="PTHR12216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01175">
        <property type="entry name" value="Urocanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17392">
        <property type="entry name" value="Urocanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17391">
        <property type="entry name" value="Urocanase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001423">
        <property type="entry name" value="Urocanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111326">
        <property type="entry name" value="SSF111326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01228">
        <property type="entry name" value="hutU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01233">
        <property type="entry name" value="UROCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0369">Histidine metabolism</keyword>
    <keyword evidence="7 9 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urocanase_N" evidence="11">
        <location>
            <begin position="88"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase" evidence="10">
        <location>
            <begin position="217"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Urocanase_C" evidence="12">
        <location>
            <begin position="444"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS13123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="674" mass="75758" checksum="E648AC0E633DD0F6" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JH0</accession>
    <name>Q73JH0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973203.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680597.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2605"/>
    <dbReference type="EnsemblBacteria" id="AAS13122">
        <property type="protein sequence ID" value="AAS13122"/>
        <property type="gene ID" value="TDE_2605"/>
    </dbReference>
    <dbReference type="GeneID" id="2741309"/>
    <dbReference type="KEGG" id="tde:TDE_2605"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2463"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_9_4_12"/>
    <dbReference type="OMA" id="VENKICG"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="180" mass="20777" checksum="FF407D14B0AB3BED" modified="2004-07-05" version="1">MKLFVVRHGETDWNSKMLACGVSEALLTEKGKNQAKELAERLAAEQDKNKIRVIYVSPLKRAVATAAYIEKALGIKAVIDDRLKEINFGTFEGKDWRRPEFLKITDNPFFRFSQGESLVQTAHRAYGIIEEVKIKHKNENVLFVCHGMISTMICTYFRSYSQEELEKIEIKNCQLLQFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JL0</accession>
    <name>Q73JL0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973007.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667639.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2408"/>
    <dbReference type="EnsemblBacteria" id="AAS12926">
        <property type="protein sequence ID" value="AAS12926"/>
        <property type="gene ID" value="TDE_2408"/>
    </dbReference>
    <dbReference type="GeneID" id="44155131"/>
    <dbReference type="KEGG" id="tde:TDE_2408"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2274"/>
    <dbReference type="HOGENOM" id="CLU_203717_0_0_12"/>
    <dbReference type="OMA" id="KFFCSCG"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="56" mass="6126" checksum="4899970B3D396A69" modified="2004-07-05" version="1">MAGASKNSRTAAATQKFNCPCGGDIVLKTMVDNGKIKNIAECSKCKRVERRPKDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JL9</accession>
    <name>Q73JL9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease P protein component</fullName>
            <shortName evidence="5">RNase P protein</shortName>
            <shortName evidence="5">RNaseP protein</shortName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rnpA</name>
        <name evidence="6" type="ordered locus">TDE_2399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972998.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957225.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2399"/>
    <dbReference type="EnsemblBacteria" id="AAS12917">
        <property type="protein sequence ID" value="AAS12917"/>
        <property type="gene ID" value="TDE_2399"/>
    </dbReference>
    <dbReference type="GeneID" id="2740701"/>
    <dbReference type="KEGG" id="tde:TDE_2399"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2265"/>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117179_9_4_12"/>
    <dbReference type="OMA" id="DFAFIVY"/>
    <dbReference type="OrthoDB" id="2014742at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="118" mass="13723" checksum="05FAF3D3DB140A5D" modified="2004-07-05" version="1">MSNFTFSGEERLRDRSCIKAVFQKGLKLSLNGVSLLILPNGLEYNRFLCTFRRGFGSAVMRNRSRRISKEAYRHIKHRLKTGNDIILLVFSEKDSYSLRLEQLTALFLKAKMYNDEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JM0</accession>
    <name>Q73JM0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972996.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2397"/>
    <dbReference type="EnsemblBacteria" id="AAS12915">
        <property type="protein sequence ID" value="AAS12915"/>
        <property type="gene ID" value="TDE_2397"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2397"/>
    <dbReference type="HOGENOM" id="CLU_218470_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="43" mass="4827" checksum="C8AF7E76BC5328D5" modified="2004-07-05" version="1">MINSSVEILPHCLSSSFVQSTKHRIIVCSFAKAKLLEKTFFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JN0</accession>
    <name>Q73JN0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">malQ</name>
        <name evidence="8" type="ordered locus">TDE_2387</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972986.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680318.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2387"/>
    <dbReference type="CAZy" id="GH77">
        <property type="family name" value="Glycoside Hydrolase Family 77"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12905">
        <property type="protein sequence ID" value="AAS12905"/>
        <property type="gene ID" value="TDE_2387"/>
    </dbReference>
    <dbReference type="GeneID" id="2740689"/>
    <dbReference type="KEGG" id="tde:TDE_2387"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2255"/>
    <dbReference type="eggNOG" id="COG1640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014132_1_0_12"/>
    <dbReference type="OMA" id="TGQLWGT"/>
    <dbReference type="OrthoDB" id="814704at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="540" mass="62847" checksum="CEBB41BC644575A1" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JV9</accession>
    <name>Q73JV9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensor histidine kinase/response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973100.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680470.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2502"/>
    <dbReference type="EnsemblBacteria" id="AAS13019">
        <property type="protein sequence ID" value="AAS13019"/>
        <property type="gene ID" value="TDE_2502"/>
    </dbReference>
    <dbReference type="GeneID" id="2741475"/>
    <dbReference type="KEGG" id="tde:TDE_2502"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2369"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_104_15_12"/>
    <dbReference type="OMA" id="MDGWQFA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
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        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="150"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="395"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="560"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="676" mass="76760" checksum="5A13FF5903AFF6B9" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JY5</accession>
    <name>Q73JY5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973126.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680496.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2528"/>
    <dbReference type="EnsemblBacteria" id="AAS13045">
        <property type="protein sequence ID" value="AAS13045"/>
        <property type="gene ID" value="TDE_2528"/>
    </dbReference>
    <dbReference type="GeneID" id="2739040"/>
    <dbReference type="KEGG" id="tde:TDE_2528"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2392"/>
    <dbReference type="eggNOG" id="COG3762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086382_0_1_12"/>
    <dbReference type="OMA" id="VWILGDR"/>
    <dbReference type="OrthoDB" id="1927539at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="230" mass="25611" checksum="1FBF5398A93A7BD2" modified="2004-07-05" version="1">MENKRILNKIHIKPKDLDLIKNAVAEAEKTTNGEIALAVIPQSDSYSFVELFAAVCLAFISFFVMLYFGNGIWKLLETKLWYPSPKTLTAVIGAGVFVVMLLFFLLINIPALDRLIIPKKIKEARVYARALKHFVECGIYKTAERTGILIFVSILERKVFIIADSGIAEKVEQGTWNGICGIITSGLKSKNTANSFCKAVEECGKILAEHFPKTKGNPNEYPDGLVILDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JZ3</accession>
    <name>Q73JZ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_2546</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973144.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667339.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2546"/>
    <dbReference type="EnsemblBacteria" id="AAS13063">
        <property type="protein sequence ID" value="AAS13063"/>
        <property type="gene ID" value="TDE_2546"/>
    </dbReference>
    <dbReference type="GeneID" id="2739911"/>
    <dbReference type="KEGG" id="tde:TDE_2546"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2407"/>
    <dbReference type="eggNOG" id="COG1284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063199_1_1_12"/>
    <dbReference type="OMA" id="AQIIHKY"/>
    <dbReference type="OrthoDB" id="1747063at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="232"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS13063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="294" mass="31487" checksum="FA3436DAFEB65AFC" modified="2004-07-05" version="1">MNKILPAKHISTKFVIGVLLDIFWVTVGSVLAAVALQFFLIPGTIAPGGVSGLSVAIEKLTGIRVYILNLIINVPLFIFGAKLLGKKSAVFTLLSILVLSGVLAVLPQDFVFTNDLFLQATFGGILLGVGLGIVFKRGATTGGTDLAGAIVNKHFPGLSIAKGMAIADFVIVAFAGVVDNNPNTSLYSLIALFFCTKIADMILDGLSYFKGFFIVSSKPAEIGDALMSKLERGVTLLKGEGMYSKQDRPVLLCVVSRAQFVRAKEIITEIDEKAFIMVCDMQEVYGLGFKQKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JZ7</accession>
    <name>Q73JZ7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antigen, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973140.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680509.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2542"/>
    <dbReference type="EnsemblBacteria" id="AAS13059">
        <property type="protein sequence ID" value="AAS13059"/>
        <property type="gene ID" value="TDE_2542"/>
    </dbReference>
    <dbReference type="GeneID" id="2739907"/>
    <dbReference type="KEGG" id="tde:TDE_2542"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2405"/>
    <dbReference type="eggNOG" id="ENOG5031BZG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_571002_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285921" evidence="1">
        <location>
            <begin position="29"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="461" mass="50190" checksum="266C5946E6FDF1CE" modified="2004-07-05" version="1">MKKNVILLFAAALLTAALILQTSCNLTAPEYGIVTLDFENGAARSIGANGLPNLSDSTMQIDITGNSIVPITKQLEKDEPKVFSQFLPVGETIHIKVSIITPSATWAGFTDLTVESGDNEAAVKLNKVIASMWPVLFSVEGSGSTGYIFKLNMSGIPLAITQSGSGRDYLFFTRDGKGRLYAAYSDPPVVIRRYTSEGDYEKKLSLPVGVTAVDSFTTDLKTGKVYMSSGSTLYEIDDNGNLMHVIGSAGTIKASAAYNGYLFVYSSLPAGGQLQMYRLTGTPPALVGTLPQDPLKDIIPITGDPSMGDPAITHKSGECQDMFAYGNKVYIVFTIDAPYDGSKAFYGGVLEYTYTENGHMTESGRYGFGRMKSYRKFGPSPQTAVYKFEGEPKDRFYGARRIIGFEDGVLYIADDGAIFSSIEGAQGYTVYPNINRIAKLDTRSGTLTFENTDAKWYREWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K31</accession>
    <name>Q73K31_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dnaX</name>
        <name evidence="7" type="ordered locus">TDE_2586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973184.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957269.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2586"/>
    <dbReference type="EnsemblBacteria" id="AAS13103">
        <property type="protein sequence ID" value="AAS13103"/>
        <property type="gene ID" value="TDE_2586"/>
    </dbReference>
    <dbReference type="GeneID" id="2741290"/>
    <dbReference type="KEGG" id="tde:TDE_2586"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2445"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_0_4_12"/>
    <dbReference type="OrthoDB" id="556582at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
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            <end position="178"/>
        </location>
    </feature>
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        <location>
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            <end position="410"/>
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    </feature>
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            <end position="454"/>
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        <location>
            <begin position="590"/>
            <end position="612"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS13103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="612" mass="68250" checksum="2D680D6A6F9F57D1" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K91</accession>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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                <person name="Paulsen I.T."/>
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            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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        <property type="protein sequence ID" value="AAS12847.1"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:secondary active p-aminobenzoyl-glutamate transmembrane transporter activity"/>
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        <property type="entry name" value="AbgT"/>
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            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
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        <source>
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            <dbReference type="EMBL" id="AAS12847.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KC3</accession>
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        </submittedName>
    </protein>
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        <name evidence="8" type="ordered locus">TDE_2295</name>
    </gene>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
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        <property type="protein sequence ID" value="AAS12814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS12814">
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        <property type="gene ID" value="TDE_2295"/>
    </dbReference>
    <dbReference type="GeneID" id="2740260"/>
    <dbReference type="KEGG" id="tde:TDE_2295"/>
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        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="SSF82861"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
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        <location>
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            <end position="103"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KC4</accession>
    <name>Q73KC4_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Hydrolase, haloacid dehalogenase-like family</fullName>
        </submittedName>
    </protein>
    <gene>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972894.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675739.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2294"/>
    <dbReference type="EnsemblBacteria" id="AAS12813">
        <property type="protein sequence ID" value="AAS12813"/>
        <property type="gene ID" value="TDE_2294"/>
    </dbReference>
    <dbReference type="GeneID" id="2740259"/>
    <dbReference type="KEGG" id="tde:TDE_2294"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2164"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_3_12"/>
    <dbReference type="OMA" id="FPIATRV"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="233" mass="27043" checksum="94F8F95998967C24" modified="2004-07-05" version="1">MKYGISAIAFDIDGTLYPSWRFNLRIIPFLLKNFNFMSAFNKTRKDIRLWQEKNPDKVLSNFFDFQAEILAKHAGKNKEDVKNFLETEIYEGWKKRFARIKPYFFARESIEEFKRCGLKIALLSDFLPEQKNDVWGILPLCDAAFGTEAIGALKPSPLPFKRLAEALDLPCDKILYVGNNLRYDVAGAKAAGMHTACIKSRLFILLKKVFAQKDNEKPDIYFSNYRQLLKFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KC7</accession>
    <name>Q73KC7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispD</name>
        <name evidence="1" type="ordered locus">TDE_2291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972891.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680203.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2291"/>
    <dbReference type="EnsemblBacteria" id="AAS12810">
        <property type="protein sequence ID" value="AAS12810"/>
        <property type="gene ID" value="TDE_2291"/>
    </dbReference>
    <dbReference type="GeneID" id="2740256"/>
    <dbReference type="KEGG" id="tde:TDE_2291"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2161"/>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061281_2_2_12"/>
    <dbReference type="OMA" id="GARCYIS"/>
    <dbReference type="OrthoDB" id="1836139at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070567">
        <property type="term" value="F:cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="243" mass="27197" checksum="0E2BE8B467FA54CE" modified="2004-07-05" version="1">MRTIKSLGFAAVITAAGKSQRMNLDTKKEYLRLPEYGEGVTVLSECLLKFLQTKLFEVIVVTVPAKDISDANNLIFNDKRIEKALLKKNTKIIFTAGADTRQTSVFKALAKLGELKEKKEADFNFVLIHDGARPWVSPELIKRVSDEVSKREAVIPGYQAVDTQKIADKSGKITQHLKRSSVYSVQTPQGFDFEKILAAHKQALENGKEYTDDSEIYGEFAGDVFICTGEVSNKKITFKEDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KI4</accession>
    <name>Q73KI4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron compound ABC transporter, periplasmic iron compound-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972834.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680087.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2234"/>
    <dbReference type="EnsemblBacteria" id="AAS12753">
        <property type="protein sequence ID" value="AAS12753"/>
        <property type="gene ID" value="TDE_2234"/>
    </dbReference>
    <dbReference type="GeneID" id="2741339"/>
    <dbReference type="KEGG" id="tde:TDE_2234"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2110"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_2_5_12"/>
    <dbReference type="OMA" id="KVYFEEW"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284558" evidence="1">
        <location>
            <begin position="24"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="2">
        <location>
            <begin position="53"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="311" mass="33563" checksum="8F6EC9F7F6BDD6FD" modified="2004-07-05" version="1">MKSLKKIFFVLAMLLAAGTMVFAGGAKEASLPSIDLTMDRAGAPITLPAKVERIISMAPSTTEILIDLGVADKIIAADTNTQKDGLLKQNIPYFDMMKPDAEKLIALKPDVVFISGMSNAKGNTPFSPLIDAGICVVNIPSSSSIEAIYLDIAYIAAVVKQEGNGAKIIANMKKEIEAVRKKGASIAQDKKKTVYFEIGAAPYMYSLGTGTFINEMIEIIGAQNILADQKSWVSVSDEMVLAKDPDVILTNVNYIPNPIDEIMSRSGWASLKAVKGKKVFGIDTNSSSRPNHNIIKALKEMAKAVYPEIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KJ3</accession>
    <name>Q73KJ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972825.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680077.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2225"/>
    <dbReference type="EnsemblBacteria" id="AAS12744">
        <property type="protein sequence ID" value="AAS12744"/>
        <property type="gene ID" value="TDE_2225"/>
    </dbReference>
    <dbReference type="GeneID" id="2739501"/>
    <dbReference type="KEGG" id="tde:TDE_2225"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2101"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_7_3_12"/>
    <dbReference type="OMA" id="HIDLFQH"/>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="135" mass="15589" checksum="DFBE0F6739B581A9" modified="2004-07-05" version="1">MTHTFYVEVRSYELDAYNHVNNSVYLNYLEYARMQFLKKIGFDYVGMIEEGYMLYVSHIDIKYKHSAKLYDKLAIEVTHIDLGKVSGTFLQVIKNEEGKVCAEAKVTWACVDSTGRPVKIPEKYLVPGLEPELQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KP9</accession>
    <name>Q73KP9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972769.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2168"/>
    <dbReference type="EnsemblBacteria" id="AAS12688">
        <property type="protein sequence ID" value="AAS12688"/>
        <property type="gene ID" value="TDE_2168"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2168"/>
    <dbReference type="HOGENOM" id="CLU_3259296_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="42" mass="5205" checksum="9CEAF707CA9017A5" modified="2004-07-05" version="1">MLSLRFISIQFYLKSFLFFYLLFSTFMIKFKIKCLRINPQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KS6</accession>
    <name>Q73KS6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972742.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12661">
        <property type="protein sequence ID" value="AAS12661"/>
        <property type="gene ID" value="TDE_2141"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2141"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2022"/>
    <dbReference type="HOGENOM" id="CLU_2921408_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="61" mass="7057" checksum="D664B8A88DF8BFAF" modified="2004-07-05" version="1">MPEKSTPMPSFLFQRVALGLCPKNPRIQGSGVFYFFGIDGSQSRHADIKKHMEYLFLCFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KV1</accession>
    <name>Q73KV1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972717.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679927.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2116"/>
    <dbReference type="EnsemblBacteria" id="AAS12636">
        <property type="protein sequence ID" value="AAS12636"/>
        <property type="gene ID" value="TDE_2116"/>
    </dbReference>
    <dbReference type="GeneID" id="2739375"/>
    <dbReference type="KEGG" id="tde:TDE_2116"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1999"/>
    <dbReference type="eggNOG" id="ENOG5033Q9N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011448_0_0_12"/>
    <dbReference type="OMA" id="LYPEMSQ"/>
    <dbReference type="OrthoDB" id="654985at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284577" evidence="1">
        <location>
            <begin position="22"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="976" mass="110054" checksum="2E5ECF9ADC4CC649" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KZ0</accession>
    <name>Q73KZ0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972678.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679875.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2077"/>
    <dbReference type="EnsemblBacteria" id="AAS12589">
        <property type="protein sequence ID" value="AAS12589"/>
        <property type="gene ID" value="TDE_2077"/>
    </dbReference>
    <dbReference type="GeneID" id="2741204"/>
    <dbReference type="KEGG" id="tde:TDE_2077"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1962"/>
    <dbReference type="HOGENOM" id="CLU_1199364_0_0_12"/>
    <dbReference type="OMA" id="SENDYSA"/>
    <dbReference type="OrthoDB" id="1458246at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="231" mass="26218" checksum="A8EA43B53779EE40" modified="2004-07-05" version="1">MCRFVLNRGHMLGKKLLCLLSIFIFFSCGIDDIVYLEPPKLTHSPTGHTDPALMYFEFETSDKKNWGIGEFLGFEVYYRIYESETDCKNLIKNIVQYNESNPANSVNYLLSSYNYKLLTYQGHSYQDRPIVLAPVASPANDRLVKFRLETVNSLSNDFDIAGTTQGKVLRQFGEEFTAAKHGDYDVQSSSNPSADSFYVAVFAATYGYDISFKPIYSELVSLGYVKIKKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L41</accession>
    <name>Q73L41_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972627.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2024"/>
    <dbReference type="EnsemblBacteria" id="AAS12538">
        <property type="protein sequence ID" value="AAS12538"/>
        <property type="gene ID" value="TDE_2024"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2024"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1910"/>
    <dbReference type="HOGENOM" id="CLU_1874525_0_0_12"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="136" mass="16263" checksum="3D48731036434819" modified="2004-07-05" version="1">MGGIYNTVNLHVYHYAGNNPIKYTDPDGKWFFIDDLLVSIFAKLEGLQDEGIFQGMWMYFKASWMHPIDYGKAFIKFVKFIYEKYKVLKIPINNKLKFFIDWEKKRIGVKTPDIKETEMNIPEFKIFENNDKENMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L86</accession>
    <name>Q73L86_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972582.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669806.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1979"/>
    <dbReference type="EnsemblBacteria" id="AAS12493">
        <property type="protein sequence ID" value="AAS12493"/>
        <property type="gene ID" value="TDE_1979"/>
    </dbReference>
    <dbReference type="GeneID" id="2741542"/>
    <dbReference type="KEGG" id="tde:TDE_1979"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1869"/>
    <dbReference type="eggNOG" id="ENOG5030TZW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192351_0_0_12"/>
    <dbReference type="OMA" id="EMRCELG"/>
    <dbReference type="OrthoDB" id="2057861at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="76" mass="8571" checksum="5BF21C30310C782F" modified="2004-07-05" version="1">MHTMTMTNKVYQALELAVKITGAAKDTVLENALSRYLAELQEDAEDAQLAEKAWNDFEKSGERTYTIAEMRCELGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L97</accession>
    <name>RLME_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase E</fullName>
            <ecNumber evidence="1">2.1.1.166</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA Um2552 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmE</name>
        <name evidence="1" type="synonym">ftsJ</name>
        <name evidence="1" type="synonym">rrmJ</name>
        <name type="ordered locus">TDE_1968</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42720"/>
            <dbReference type="Rhea" id="RHEA-COMP:10202"/>
            <dbReference type="Rhea" id="RHEA-COMP:10203"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.166"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.166" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972571.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669797.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73L97"/>
    <dbReference type="SMR" id="Q73L97"/>
    <dbReference type="STRING" id="243275.TDE_1968"/>
    <dbReference type="EnsemblBacteria" id="AAS12482">
        <property type="protein sequence ID" value="AAS12482"/>
        <property type="gene ID" value="TDE_1968"/>
    </dbReference>
    <dbReference type="GeneID" id="2741531"/>
    <dbReference type="KEGG" id="tde:TDE_1968"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1860"/>
    <dbReference type="eggNOG" id="COG0293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009422_4_4_12"/>
    <dbReference type="OMA" id="HRQTDHL"/>
    <dbReference type="OrthoDB" id="1798571at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005461">
        <property type="entry name" value="23S_rRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000155544" description="Ribosomal RNA large subunit methyltransferase E">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01547"/>
        </source>
    </evidence>
    <sequence length="199" mass="22359" checksum="89447C73ADA33F9E" modified="2004-07-05" version="1">MAKNKYSEPDYWSKKAFAENYPARSVYKLEEMNKKFNLFSPNDKVLDLGAAPGSWTVYVLRFLNKEGRVTAVDLKPLDSSVYDERLNFFQGDMFDKGIIKSVKELGPYDAVICDAAPATTGNKTVDTARSSGLVELALYYAQEQLKQGGSFVVKIFQGGDQQIHLNNLRKCFKTARAFKPEACRSSSFETYLIGLDFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L99</accession>
    <name>Q73L99_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trypsin domain/PDZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">htrA-1</name>
        <name evidence="2" type="ordered locus">TDE_1966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972569.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679693.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73L99"/>
    <dbReference type="STRING" id="243275.TDE_1966"/>
    <dbReference type="EnsemblBacteria" id="AAS12480">
        <property type="protein sequence ID" value="AAS12480"/>
        <property type="gene ID" value="TDE_1966"/>
    </dbReference>
    <dbReference type="GeneID" id="2741529"/>
    <dbReference type="KEGG" id="tde:TDE_1966"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1858"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_2_0_12"/>
    <dbReference type="OMA" id="DTRHFDY"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="321"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="425" mass="45037" checksum="226878FB414F4C4C" modified="2004-07-05" version="1">MKLYSRRQTLVFSLIAAVIFASAGFFAGIKYSTGNAGSTGIQSGTSSNPADFEESAENGFAQTENSHNLNMQQHGNTAALNTANEAGYMGYTPAESQNIRVYESTNEAVVNITTETMGANWFFEPVPVEGSSGSGSIIDESGLVLTNAHVISEASKIYISLSDGSQYEAKVVGTDAENDLAVLKFDPPKNIKLTVIKLGDSTNLKVGQRVLAIGNPFGLERTLTDGIVSALKRPIQNDKNIIIKNMIQTDTAINPGNSGGPLLDTQGRMIGINTMIYSTSGSSAGVGFAVPVNTAKRVVADILKYGKVIRGSIDADLVQVSGRLASYAKLPVSYGLLVSEVKKGSNAAKAGLRGGNEAVRSGVGRYSSVFYIGGDIIVEIAGQKINNITDYYSVLEDKKPGETVKVKIVRGKKLVDLSLTLSERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LG1</accession>
    <name>Q73LG1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972506.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679601.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12417">
        <property type="protein sequence ID" value="AAS12417"/>
        <property type="gene ID" value="TDE_1903"/>
    </dbReference>
    <dbReference type="GeneID" id="2740401"/>
    <dbReference type="KEGG" id="tde:TDE_1903"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1802"/>
    <dbReference type="eggNOG" id="ENOG5032MJ5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1299264_0_0_12"/>
    <dbReference type="OrthoDB" id="1660743at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025699">
        <property type="entry name" value="ABC2_memb-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13346">
        <property type="entry name" value="ABC2_membrane_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="212" mass="24653" checksum="213875EDBFC7283F" modified="2004-07-05" version="1">MRQLLLTHIRKIKNNKQIFIILFLLSPIIIAATNNPLMVFFPYLVSMHLFSGITKVERKEGIKQGEDILLNSLPVSRKEIVISRYLIILLFGLLMISTFLGFSFIISFLVRNPFQISSIFFINFFIIQFIYNILFIPLEYLSFAKSQIIKGVVYMGAIFVFSGIKNLNIYVLNLLNTFKENSFYVMIFTGIIILSIPVSIFFSIKIYEKKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LI0</accession>
    <name>Q73LI0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972486.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679579.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1883"/>
    <dbReference type="EnsemblBacteria" id="AAS12397">
        <property type="protein sequence ID" value="AAS12397"/>
        <property type="gene ID" value="TDE_1883"/>
    </dbReference>
    <dbReference type="GeneID" id="2739112"/>
    <dbReference type="KEGG" id="tde:TDE_1883"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1785"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_21_3_12"/>
    <dbReference type="OMA" id="AYTLQIV"/>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="160"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="310" mass="34155" checksum="12C276868B6F833F" modified="2004-07-05" version="1">MSFKLKSGSRIRILSRLALLSATLLWGSTFVAVSSTNDFFKPNFLLACRFLPACLILCAVFFKRLKQLDKRYVKAGMILGLIMFAGYSLQAIAITTAGGLPGRSSFLVATYCVLVPFVNAVVLKKRPDKFNLFAAFLCFAGILAISMPDLISESQKGINWGDVLSLISSFIFAVYIVLLPKFMEELDVPLITLTQFAFAGTYALIFSLLFEDNSNTVWNYQSVFTLVYLTVLCTALCVLLQAVGQKNTPPTTAALIFSLESVFSIFLSIMLTDEKFTPALALGCSFIFIAIIISETKLSFLKKKSVEVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LI3</accession>
    <name>Q73LI3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972483.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669683.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1880"/>
    <dbReference type="EnsemblBacteria" id="AAS12394">
        <property type="protein sequence ID" value="AAS12394"/>
        <property type="gene ID" value="TDE_1880"/>
    </dbReference>
    <dbReference type="GeneID" id="2739109"/>
    <dbReference type="KEGG" id="tde:TDE_1880"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1782"/>
    <dbReference type="eggNOG" id="ENOG502ZM16">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122425_0_0_12"/>
    <dbReference type="OMA" id="TRIEGIY"/>
    <dbReference type="OrthoDB" id="1518607at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="147" mass="17132" checksum="B5C83137248A5670" modified="2004-07-05" version="1">MLHKIVFQDNLFQITRMLDVIKDGLNLDLSESIFADKMMRDILFFDAALQKLFNQIEPQSHLPDYIDTMNCLYFCIKKYMSVLKLILTEKLGGESIFNTEKTRIEGIYKKHQDFLGKINIDISDTNIENETYNIVSQNELSELLNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LJ1</accession>
    <name>Q73LJ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972475.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957083.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1871"/>
    <dbReference type="EnsemblBacteria" id="AAS12386">
        <property type="protein sequence ID" value="AAS12386"/>
        <property type="gene ID" value="TDE_1871"/>
    </dbReference>
    <dbReference type="GeneID" id="2740060"/>
    <dbReference type="KEGG" id="tde:TDE_1871"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1773"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084787_0_0_12"/>
    <dbReference type="OMA" id="RYKNVYY"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="286" mass="34412" checksum="A8F0C450AC129F39" modified="2004-07-05" version="1">MNKKIMKDLCILFILYILVFFMLSYVGKFLFKNFYNYYYILFVKYNGIFGSLLFLLFIIIFYLFYSKDLKIIFIYKKLNFSFIVKILIYILSTRMIYYIIYFIFDNAFLFNFFKYFNDVLTGKKNITIYDILILEKSLKPRFEPFMLIGSVIFGPIFEEILYRGLMYNKLKEISNAFIGVLISSILFALLHIPKYGFGINTFFLFLVGILLTYCYEKTNNIYIPILVHSISNFFIFLFNYVYFYFLIVIYFIIFIAGIIIAIQEIKKHLKVRKTFNFVQSDFPSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LM6</accession>
    <name>Q73LM6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972440.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679541.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1836"/>
    <dbReference type="EnsemblBacteria" id="AAS12351">
        <property type="protein sequence ID" value="AAS12351"/>
        <property type="gene ID" value="TDE_1836"/>
    </dbReference>
    <dbReference type="GeneID" id="2740498"/>
    <dbReference type="KEGG" id="tde:TDE_1836"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1742"/>
    <dbReference type="eggNOG" id="ENOG5031DIM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899982_0_0_12"/>
    <dbReference type="OrthoDB" id="2106568at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="309" mass="36970" checksum="B9B0C42336EDC9C5" modified="2004-07-05" version="1">MRKVVLVIVLFFSVNCLFSEENKYFFYIPSTEEMQSYFSMKNYLSQWDAGKRVVDDLTFDKIYRNNIGKETINSLLLESFFRNTRNAKIQQQLKQYIKSNKIDSSFSKAIVKKIDSKLEKEKTSEKEVWRYNYDDKEFDENINLFNFREAGVFNNKLGMLLFDNDWNQISFTQKEKTSKDKFFLIYGGGTNSITINFYEKNGVKREDLDVAMNQRYYKNRHPNNWQSIELDREGILWNCGADKYIIAFGSDPESNSATFNAYLYDEKEKKLYLMSTSMNFSKINMFYSERYRIYNYLLFNSLFCFINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LR4</accession>
    <name>Q73LR4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972402.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957051.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1798"/>
    <dbReference type="EnsemblBacteria" id="AAS12313">
        <property type="protein sequence ID" value="AAS12313"/>
        <property type="gene ID" value="TDE_1798"/>
    </dbReference>
    <dbReference type="GeneID" id="2739228"/>
    <dbReference type="KEGG" id="tde:TDE_1798"/>
    <dbReference type="HOGENOM" id="CLU_2738849_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="71" mass="7916" checksum="16B74C40532D16B6" modified="2004-07-05" version="1">MSDGFDFDKFLAAGERAFNNNVLPQGKQKQPDSFVCKPGDSQNPNITHMTEGYDPKVSYHNFSDDKNTSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LS1</accession>
    <name>Q73LS1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972395.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1791"/>
    <dbReference type="EnsemblBacteria" id="AAS12306">
        <property type="protein sequence ID" value="AAS12306"/>
        <property type="gene ID" value="TDE_1791"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1791"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1704"/>
    <dbReference type="eggNOG" id="ENOG5031D7A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1694718_0_0_12"/>
    <dbReference type="OrthoDB" id="2115634at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="155" mass="18797" checksum="AF37E4918AC7C6DA" modified="2004-07-05" version="1">MKRTVSLLFICIYLFNCYAINFEINSKSYPHWVFQQYNFCHEENTDSKNHNNIVLWTHTVQTWPFGILYDDFSFLVDKNISWKKMMIYSFSYQSENGEVFIIKNKIINNHGNMFNEIKKYWLVKEMKNEKNFIGKIVYSFDDGELITEYTEITVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LY3</accession>
    <name>Q73LY3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972333.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957027.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1729"/>
    <dbReference type="GeneID" id="2739187"/>
    <dbReference type="KEGG" id="tde:TDE_1729"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1653"/>
    <dbReference type="eggNOG" id="COG0386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029507_2_2_12"/>
    <dbReference type="OMA" id="LAPFKGQ"/>
    <dbReference type="OrthoDB" id="1635499at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0711">Selenium</keyword>
    <keyword evidence="6" id="KW-0712">Selenocysteine</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="6">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="155" mass="17581" checksum="C46E8A665343A046" modified="2008-02-26" version="2">MGIYNYTVKDSLGNDFSFNDYKDYVILIVNTACEUGLTPHFQGLEALYKEYRDKKFLVAAFPCNQFGGQDPGTNEEIRNFAQSKYGVSFPIMAKIEVNGENTEPIFSFLKKASNGEDIKWNFAKFLVDKTGERVTAYAPTVAPEDLKKDIEKLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M67</accession>
    <name>Q73M67_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972248.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679326.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1642"/>
    <dbReference type="EnsemblBacteria" id="AAS12159">
        <property type="protein sequence ID" value="AAS12159"/>
        <property type="gene ID" value="TDE_1642"/>
    </dbReference>
    <dbReference type="GeneID" id="2739751"/>
    <dbReference type="KEGG" id="tde:TDE_1642"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1570"/>
    <dbReference type="eggNOG" id="ENOG5031C89">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088597_0_0_12"/>
    <dbReference type="OMA" id="QLENGMA"/>
    <dbReference type="OrthoDB" id="1782246at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="238" mass="26874" checksum="75235AA400F030ED" modified="2004-07-05" version="1">MNRKILSILSAFMFLIVLDSCKTAPKNDPNFLGDFSPIDLGTLIGGSVKRTKEEIKPTEFKFTFYPRTNIVSIEHKFMIDKVEVFLDQADREILIKAMETYLSSYNDRNLSAANAKRKAFFGKTKVSMTWGLFGGGAHEAKPTLRAEYQLLSENKPYFILGNATTKAIGERDDASCPALRLAFSPAQCEDLIELLKQDNLVKIVEGMQKDFDRFEPSNKTENGNKENAEKDKVNYDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M81</accession>
    <name>Q73M81_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">bPH_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972234.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1628"/>
    <dbReference type="EnsemblBacteria" id="AAS12145">
        <property type="protein sequence ID" value="AAS12145"/>
        <property type="gene ID" value="TDE_1628"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1628"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1556"/>
    <dbReference type="eggNOG" id="ENOG5030W34">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1991675_0_0_12"/>
    <dbReference type="OrthoDB" id="1698951at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027783">
        <property type="entry name" value="Bacterial_PH-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10882">
        <property type="entry name" value="bPH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="bPH_5" evidence="1">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="125" mass="13850" checksum="FDE0D044FF003F71" modified="2004-07-05" version="1">MFFTIGLLLLIFLGIFVVIKTADASVEGELLKVKGIYGVSIPISEIREVKKLETLPSLGVRRVNGIGLGPIKIGYFRYNELGSVKLCILKNEAPYILVITDEQKILIGLGKGKNEELYNKLKDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M97</accession>
    <name>Q73M97_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyl transferase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972218.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671073.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1612"/>
    <dbReference type="EnsemblBacteria" id="AAS12129">
        <property type="protein sequence ID" value="AAS12129"/>
        <property type="gene ID" value="TDE_1612"/>
    </dbReference>
    <dbReference type="GeneID" id="2740853"/>
    <dbReference type="KEGG" id="tde:TDE_1612"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1541"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_1_1_12"/>
    <dbReference type="OMA" id="PSMIMSK"/>
    <dbReference type="OrthoDB" id="1581906at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="353" mass="40091" checksum="22CD6E8FADE87D90" modified="2004-07-05" version="1">MGKVIMGAEALDGYLTEDDLRHLNEMNALYQEAIENFAVLEKENGEKKKKAKDEVIRLYTEMGHLMQNICKDIPQLKVFSFDTEHENHAEASRVIAKLRSIKTEHSEFLYYTQRSFEMLFKLAYKGHQKDKKNYLVVKTPVTNPVQNYAVHKITDIDHKIENTVMCVMLRGALLPSMILSKEIEEYSSHGYVTPFALFKIKRDDSRKEDDMQYILDLDKSYFNLKDLDGKDLIFADPMNATGGSLVTVVKHLKKLGVKPKSISCFHVISALKGALRIVRALDNCTLYTLWMDPALNASAYIMPGLGDAGDRINGTDTDETPRNIIQLLADYGSNIAGLYRSQLRQIEKTVLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MC4</accession>
    <name>Q73MC4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972191.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679261.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1585"/>
    <dbReference type="EnsemblBacteria" id="AAS12102">
        <property type="protein sequence ID" value="AAS12102"/>
        <property type="gene ID" value="TDE_1585"/>
    </dbReference>
    <dbReference type="GeneID" id="2739782"/>
    <dbReference type="KEGG" id="tde:TDE_1585"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1515"/>
    <dbReference type="eggNOG" id="ENOG5032Y0R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143568_0_0_12"/>
    <dbReference type="OMA" id="NEERYVF"/>
    <dbReference type="OrthoDB" id="1844016at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="155" mass="17546" checksum="B51F3DAAAFAD3ECB" modified="2004-07-05" version="1">MDTIMSNASFSNIYYFIIIPIGLIAYFAFAIFKTKNEKKRVTNWLNEHPNAVKVYIGKTSSVTGYLASAARQISVNSVDGERPLFFTEKLSNGFYVTPGTHIVESSFTKTRPGIIYRSVTTTYGPSKQEITVEGLKSYNYSFNTNEERYVFEAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MI3</accession>
    <name>Q73MI3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972131.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1525"/>
    <dbReference type="EnsemblBacteria" id="AAS12042">
        <property type="protein sequence ID" value="AAS12042"/>
        <property type="gene ID" value="TDE_1525"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1525"/>
    <dbReference type="HOGENOM" id="CLU_2620992_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="78" mass="9077" checksum="06B475CB6E761D7C" modified="2004-07-05" version="1">MNLLPPPPPINFYRYNFIYISILNNINIILHNKLFCILQALPEILQKSFFYLLNRTSCSANRCLSAVKITAKGVFRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MS4</accession>
    <name>Q73MS4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase, group 2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972039.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679054.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1433"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="DNASU" id="2739710"/>
    <dbReference type="EnsemblBacteria" id="AAS11950">
        <property type="protein sequence ID" value="AAS11950"/>
        <property type="gene ID" value="TDE_1433"/>
    </dbReference>
    <dbReference type="GeneID" id="2739710"/>
    <dbReference type="KEGG" id="tde:TDE_1433"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1374"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_1_12"/>
    <dbReference type="OMA" id="IHANENT"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="340" mass="39271" checksum="134EA5B49E54A7A3" modified="2004-07-05" version="1">MKFTIVIPIFNRVQYIPETLDSVIRQTYTDLEIICVDDCSSDRSPVLLQDYAKTDLRIKVLTHAKNKGLYLARKTGVLNASGDYILFLDCDDVLDLHAVEVIYNALCKNSVEVLEYGYHSIHANENTVPDSAITVDKLFSSLVYDRYPRAGTVWNKAYKTELLKNAFSKMSDFHAVMGEDFYESVIIAYYAKSYSSIDDVLVIYNDESGISNTRKNLASIQKDLDSVVAILNGFRFFFESYASEHKEAVLNIESYYIRYVYYNLILLKTNKTDRKMAVDLLKDYFSAEAAAPYFNKTKPAVTRDAVMYKIRAVIKRYISKKLREMIKKIIRRYDKKPQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MU3</accession>
    <name>Q73MU3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphonopyruvate decarboxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972020.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679014.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1414"/>
    <dbReference type="EnsemblBacteria" id="AAS11931">
        <property type="protein sequence ID" value="AAS11931"/>
        <property type="gene ID" value="TDE_1414"/>
    </dbReference>
    <dbReference type="GeneID" id="2739691"/>
    <dbReference type="KEGG" id="tde:TDE_1414"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1356"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042853_1_0_12"/>
    <dbReference type="OMA" id="PILASWR"/>
    <dbReference type="OrthoDB" id="1219810at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033980">
        <property type="term" value="F:phosphonopyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032923">
        <property type="term" value="P:organic phosphonate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017684">
        <property type="entry name" value="Phosphono-pyrv_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03297">
        <property type="entry name" value="Ppyr-DeCO2ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="229"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="378" mass="41040" checksum="3FD674DCDBF3C9CB" modified="2004-07-05" version="1">MIRPQFFYELLKENGTDFFTGVPDSLLKSFCAYITDNVEGKNHIIAANEGCAVGLAAGHYFATGRVPLVYMQNSGLGNTVNPLLSLADREVYSVPLLLVIGWRGEPNVHDEPQHIKQGRVTCSLLDAMEIPYCILSDEEAEARAQLEKAYSHIKASSSPYAVVVRKGIFDSYKLKTNEAVPAEMSREEAIEKIILNAPSNACFVSTTGMASRELYELRDKHGQGHAKDFLTVGSMGHASQIALGIALSKPGKKIFCIDGDGAAIMHLGGLTAIGSQRPKNMVHIILNNGAHDSVGGQPTVGRKINLCSIAFACGYTKVVSVKTIKELETQLKDLSSAEGSFLIEVLVSKGARADLGRPKSSPIENKRAFMEFLEEKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MU8</accession>
    <name>Q73MU8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar filament outer layer protein FlaA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasmic flagellum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972015.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668795.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1409"/>
    <dbReference type="EnsemblBacteria" id="AAS11926">
        <property type="protein sequence ID" value="AAS11926"/>
        <property type="gene ID" value="TDE_1409"/>
    </dbReference>
    <dbReference type="GeneID" id="2741276"/>
    <dbReference type="KEGG" id="tde:TDE_1409"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1351"/>
    <dbReference type="eggNOG" id="ENOG5033RD4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097187_0_0_12"/>
    <dbReference type="OMA" id="FEFANTW"/>
    <dbReference type="OrthoDB" id="820844at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006714">
        <property type="entry name" value="FlaA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04620">
        <property type="entry name" value="FlaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284603" evidence="3">
        <location>
            <begin position="21"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="246" mass="27846" checksum="4A0F82B5C95C3731" modified="2004-07-05" version="1">MKKSIAIILFLVGFVAFSFAQQNNNDFSTIDAADPNKVGVDTAEQRIKEVSIEKFETEGTWYAMMSADEGVVRARLFNGNPLNKKPIPAEEGLELADEKVLGVKVSFYRRGYNSFEVHATKALPVEGIAKTASVWVVGRSYPHTMKLIVEDFWGKRFELYVGKLNHSGWKLMTVAIPPQNAAGKTGIIQKDYHYGTSMGLKIVGFRVECDPEEAYGHYYIYFDDLRVVSDLYEVDMRDQDDMSDNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MV0</accession>
    <name>Q73MV0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972013.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677985.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1407"/>
    <dbReference type="EnsemblBacteria" id="AAS11924">
        <property type="protein sequence ID" value="AAS11924"/>
        <property type="gene ID" value="TDE_1407"/>
    </dbReference>
    <dbReference type="GeneID" id="2741274"/>
    <dbReference type="KEGG" id="tde:TDE_1407"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1349"/>
    <dbReference type="eggNOG" id="COG1078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026821_3_1_12"/>
    <dbReference type="OMA" id="RRQTPRW"/>
    <dbReference type="OrthoDB" id="370035at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045509">
        <property type="entry name" value="HD_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19276">
        <property type="entry name" value="HD_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="53"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="412" mass="47124" checksum="EAA2E4872E4E1207" modified="2004-07-05" version="1">MIELSDFSKPIRDPIWKHIWMNDELYAVTKTDSFMRLYNIKQLGPTELVYPGAGHTRAVHSIGVYNIALKMLNILLKKGADSWVSKEGSMSFLAAALLHDLGHFPFTHSLKELKLKEHEELTGELILKEPLRSVTAKTGAVPEQTAAIITGKGKEDSETVFFQKLLSGVLDPDKLDYLNRDAFYCGVPYGIQDTDFILSQLLPDKKNGIKIESKAILSVESILFSKYLMYKSVYWHKDVRIATAMMKKAIFTGLERSEFSPQDLYHQDDDGIFRLLEKSNYPEKKLAEDLRLGKIYRIIAEEAFQSDNPRHRSLEDLHKRRAAEETLAEYFSNKTGSKIGSEDIIIDIPERISFESDLFIEDEKKIFSESSTVFSKEFIKTLVPSLRKIRIAVSDKIYKKVINLKQTTLPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MV9</accession>
    <name>Q73MV9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar synthesis regulator FleN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972003.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1397"/>
    <dbReference type="EnsemblBacteria" id="AAS11914">
        <property type="protein sequence ID" value="AAS11914"/>
        <property type="gene ID" value="TDE_1397"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1397"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1339"/>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_2_12"/>
    <dbReference type="OMA" id="GANLHTC"/>
    <dbReference type="OrthoDB" id="1370117at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="1">
        <location>
            <begin position="14"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="388" mass="43118" checksum="3D6147A04A7BB689" modified="2004-07-05" version="1">MLKKGEVFMQIIPIASGKGGVGKSLIAANLAIALGQAGKRVALADLDLGASNLHLVLGVQGRKNGIGTFLTKAAEFKDIIIDTDYENVRFVPGDSEIPGFAALKIYQRNSLVKELLKLEADFLILDLGAGTHLGILDFFLLSPQGIIITSPSVTSTLDAYVFLKNIVFRMMCSSFPAKSKGGIFFEKLKNDVPGMQRLYIPTITQELMTLDPDNTKKFLSKFSHFKPRIIMNMMDDPKDAEKAMKIRRSTKQYLNVDLEHLGVIYTDAVQDKALASRLPVIRYKPQSMISQAIYRIADKLIQSEAENYSGEDFQEFSDYSFVSAEAEAETDFKSKMEYLDDLIGGEVLSSGEMSEIIKSQQFEINVLRNENLLLKTKIAKALKQGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MW2</accession>
    <name>Q73MW2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972000.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678977.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1394"/>
    <dbReference type="EnsemblBacteria" id="AAS11911">
        <property type="protein sequence ID" value="AAS11911"/>
        <property type="gene ID" value="TDE_1394"/>
    </dbReference>
    <dbReference type="GeneID" id="2741261"/>
    <dbReference type="KEGG" id="tde:TDE_1394"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1336"/>
    <dbReference type="HOGENOM" id="CLU_1453811_0_0_12"/>
    <dbReference type="OrthoDB" id="2011798at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="179" mass="20636" checksum="6571F27D3C1B7A22" modified="2004-07-05" version="1">MSLIIFYTFVSSIVFVYGIGLECLYIYLENPKKVYAFFIKNVIVVLISVSLVWALCRYILNPLGAGFLLPVLTISFLEALNLIFKLVWPKFNGLKPEEKIFSWGLVFFCLYQSSTYRECLALIFSGFFSLFVFLFVLNAIKQKTADKESFTEWKKASLFLISMGLMLSAFYLTDLSPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MX7</accession>
    <name>Q73MX7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971985.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678960.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1379"/>
    <dbReference type="EnsemblBacteria" id="AAS11896">
        <property type="protein sequence ID" value="AAS11896"/>
        <property type="gene ID" value="TDE_1379"/>
    </dbReference>
    <dbReference type="GeneID" id="2741140"/>
    <dbReference type="KEGG" id="tde:TDE_1379"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1323"/>
    <dbReference type="eggNOG" id="COG3619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073333_1_1_12"/>
    <dbReference type="OMA" id="MGMHNTI"/>
    <dbReference type="OrthoDB" id="1751020at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="214" mass="23795" checksum="EFD9958CFE35E53F" modified="2004-07-05" version="1">MSNTLKDLRFKVWIAFLTFLSGFINVGAIRSFSLPVSHHTGNVSHLALSIANKNITEVFIIGSAILAFFAGAFISGLLFHQRKFGLKKRYGILLMGLAMIFLSLALFKTPQILKVSALSFAAGVQNAMFIFYGDILVRTTHITGYLTDAAFALAMCLRGKKDKFRFFLFYSLNILFFLAGGITAGLIKIGSFFISSACLYLIAGLYYFMMRKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N02</accession>
    <name>Q73N02_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971960.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1354"/>
    <dbReference type="EnsemblBacteria" id="AAS11871">
        <property type="protein sequence ID" value="AAS11871"/>
        <property type="gene ID" value="TDE_1354"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1354"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1302"/>
    <dbReference type="HOGENOM" id="CLU_196905_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="79" mass="9354" checksum="1C4AA82C4016BA25" modified="2004-07-05" version="1">MTKSSLGVRLKIRRKTMDYSQFKPIKPTILRNPETIAYFCKCQMNPPTEEQKEVARKSVEQYSRFWDDIKKARKNAGKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N15</accession>
    <name>TILS_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="1">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tilS</name>
        <name type="ordered locus">TDE_1341</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971947.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73N15"/>
    <dbReference type="SMR" id="Q73N15"/>
    <dbReference type="STRING" id="243275.TDE_1341"/>
    <dbReference type="PRIDE" id="Q73N15"/>
    <dbReference type="EnsemblBacteria" id="AAS11858">
        <property type="protein sequence ID" value="AAS11858"/>
        <property type="gene ID" value="TDE_1341"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1341"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1289"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018869_0_1_12"/>
    <dbReference type="OMA" id="SERDQEY"/>
    <dbReference type="OrthoDB" id="666797at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000181795" description="tRNA(Ile)-lysidine synthase">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <sequence length="460" mass="52303" checksum="3DA36D3A15C89617" modified="2004-07-05" version="1">MCKIYLMAKSFLKDVLLGFSSLCDRTAAPLRLLLAVSGGADSMAMLSAFLELKSDINAEIFVLTVNHNIRPEKETLGDAQFVLDFCNDKCPCILAEIPKNTVFDEAKNRKTGIEDAARFLRYNEFEKAADSLNADYILTAHNKNDNYETVLMRLFQGSEPEALMGISPRRGRFIRPMLNISRSEIEEYLKEKNIPWREDATNLEASYLRNKVRHNLLPVLSICFDGWQSGLDKSLAKIKAQNDFVIASYKTKKEEWVLDKKEDCCRCKFLFFLSLDEALKLKFLQEGLILLKGKRRIPYSVFDDLMKLSDTKKIIFSGGFCIKKEGDEVLLFKAVTEEKTSEVFYSIWIDKPCSFDTPAGNFKALENDDGFFIVHESDKTCGIGPFKPPFCVRSRLFGDEIETSSGSKKSVKKIINEWNIDYENRNILPIIEEGGVVKGIYGAVFGKKNWYVVGDLGVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N49</accession>
    <name>Q73N49_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971913.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678830.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1307"/>
    <dbReference type="EnsemblBacteria" id="AAS11824">
        <property type="protein sequence ID" value="AAS11824"/>
        <property type="gene ID" value="TDE_1307"/>
    </dbReference>
    <dbReference type="GeneID" id="2739565"/>
    <dbReference type="KEGG" id="tde:TDE_1307"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1256"/>
    <dbReference type="eggNOG" id="ENOG502ZR82">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_550856_0_0_12"/>
    <dbReference type="OMA" id="GEEYAPQ"/>
    <dbReference type="OrthoDB" id="580335at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="495" mass="58278" checksum="5A0A096AAC29B8C2" modified="2004-07-05" version="1">MLKYRTMFDRLEPLLPKINLFLKNVGEAFTLEDLKNFIGLKNFDDSTLGIFLISLSLAYFFPDPDSDDGVWISKHGFFTGKKFCVQISDTENEMKIFIPGSRFLPFLPADKYAHESKLFYEGKEIPKRRVYLSFDRIFSFYFLYTESDLSNILCEDYEENVETFSRLHDSFNPEARFAVTAWDFSAVFDECNFDYPMRFFVHIKDWANAEFEILKESHELLEDDISNWFSLFETAVRSSLKILPMDSTTQEILSFAFFLAEDALFNENAAPMELFFERKDVFGVMPYGIEEKFGVLDEPIACPNSWFYYPYNESKEDNFFNSINRPVTEAVIDCFVLDFLSSHYVARFDDEVKGLFIKESLDFFIPEFINNYKTVSSKCKTYLEMHYDYWVNLYNPFKDDGSKDLRADLVDFYKNLVLFFNELDERKLKTSDFDGQSALIIYQIFDKIFQWSEFVSSMSPEDSNFIEVMSMSLENLSYVYTDVKVEIRNKISALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N59</accession>
    <name>Q73N59_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM domain/M23/M37 peptidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971903.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678797.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1297"/>
    <dbReference type="EnsemblBacteria" id="AAS11814">
        <property type="protein sequence ID" value="AAS11814"/>
        <property type="gene ID" value="TDE_1297"/>
    </dbReference>
    <dbReference type="GeneID" id="2741051"/>
    <dbReference type="KEGG" id="tde:TDE_1297"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1247"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_7_3_12"/>
    <dbReference type="OMA" id="YYRVERG"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
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        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
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    </dbReference>
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        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="89"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="301" mass="32840" checksum="5405C94765BE09FA" modified="2004-07-05" version="1">MYKKNILRPLFFILFSFFCFAEDIVHIIEKGDTLYSISKKYNTPIDSILKKNNLSDPSKIKIGQKLIIPVESSAKNDKKTNAKTGSEEITHVIQKGDTLYALAKKFGVKFSDILKLNGLNEKTPLKIGQILKIPQGKSQGTAQEQESKAPQDGKQEKTSITKAGSDKETQAVKPSTSTKQADSKLLWPVPASKVAYLSGKITGVVIDSVKGQAVKAVSSGKVVSTGPHRGFGQVVFVQSKTKHIYVYGGMEKIVVKKGDTIAVGQKLGELGVELLTGKARLYFMVYDKNKPIDPAKAPRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N79</accession>
    <name>Q73N79_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971883.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1276"/>
    <dbReference type="EnsemblBacteria" id="AAS11794">
        <property type="protein sequence ID" value="AAS11794"/>
        <property type="gene ID" value="TDE_1276"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1276"/>
    <dbReference type="HOGENOM" id="CLU_3405974_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3699" checksum="B1DB8B022D2B07F1" modified="2004-07-05" version="1">MTNNKNKVIIKAIKFKNKDFINLDLFIYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N91</accession>
    <name>Q73N91_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971871.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668541.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1264"/>
    <dbReference type="EnsemblBacteria" id="AAS11782">
        <property type="protein sequence ID" value="AAS11782"/>
        <property type="gene ID" value="TDE_1264"/>
    </dbReference>
    <dbReference type="GeneID" id="2740557"/>
    <dbReference type="KEGG" id="tde:TDE_1264"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1215"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063467_0_0_12"/>
    <dbReference type="OMA" id="WIGEVYR"/>
    <dbReference type="OrthoDB" id="1691271at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="374" mass="44149" checksum="3141084AF46A1EDA" modified="2004-07-05" version="1">MKKQLKIIFIVLSIFYFYSNLFCLETIDEKERPWHLLEQAKIQMEKGEFGLALHLTNKARDIHKEQMEAKYSYMFNALKPKRVKLEGDNISDVYAILNKREDHDACKILDEIFLTHPPVFFDKSISKLMSWLEKRKAFPETDYLTGRIYFAEGDYEQAMHYYKEAWNFHNFLEIPDERFNIIYALADTSKLLRKYDEQEKYLLLVLTEDPIYGTTNLESDALQAMIKTISSEKTTEKFFLLYRNRNPIALKAYMDLTEIYLEAGKNRRALATAVLASIITITNLDDLISKDDYNYKYTEFTNLLHRLNRRQDVILWAEKQNFWRAFMNLADSLSKNGNTEQALYLYSKLAESIPSIKYAQEASYKKEELAKGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N93</accession>
    <name>Q73N93_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11780">
        <property type="protein sequence ID" value="AAS11780"/>
        <property type="gene ID" value="TDE_1262"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1262"/>
    <dbReference type="HOGENOM" id="CLU_3318659_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="39" mass="4889" checksum="096CCBB21C68865A" modified="2004-07-05" version="1">MYIMCVKIRHKNLRYIKYKFSIFYNIGYPANIFTILFKH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NH7</accession>
    <name>CH60_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperonin GroEL</fullName>
            <ecNumber evidence="1">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-60</fullName>
            <shortName evidence="1">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groEL</name>
        <name evidence="1" type="synonym">groL</name>
        <name type="ordered locus">TDE_1175</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.</text>
            <dbReference type="EC" id="5.6.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971783.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670719.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NH7"/>
    <dbReference type="SMR" id="Q73NH7"/>
    <dbReference type="STRING" id="243275.TDE_1175"/>
    <dbReference type="PRIDE" id="Q73NH7"/>
    <dbReference type="EnsemblBacteria" id="AAS11694">
        <property type="protein sequence ID" value="AAS11694"/>
        <property type="gene ID" value="TDE_1175"/>
    </dbReference>
    <dbReference type="GeneID" id="2740072"/>
    <dbReference type="KEGG" id="tde:TDE_1175"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1133"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_12"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000063586" description="Chaperonin GroEL">
        <location>
            <begin position="1"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <sequence length="544" mass="58010" checksum="EB272F406245B9DA" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NK2</accession>
    <name>Q73NK2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971758.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956897.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1150"/>
    <dbReference type="EnsemblBacteria" id="AAS11639">
        <property type="protein sequence ID" value="AAS11639"/>
        <property type="gene ID" value="TDE_1150"/>
    </dbReference>
    <dbReference type="GeneID" id="2741482"/>
    <dbReference type="KEGG" id="tde:TDE_1150"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1109"/>
    <dbReference type="eggNOG" id="ENOG5030HK9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_993725_0_0_12"/>
    <dbReference type="OMA" id="MMQDPRY"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="280" mass="30386" checksum="5DBE599B3A7845EB" modified="2004-07-05" version="1">MGELDQNNGNQTPQGNGSGETQATGTSVLDAFKGAGTGSNQNPATKGDENAKGGQANKEAETYALKAWGAQLSKELKENEEAVKVLSKFEDISGLANSYIELEKKQGSMHTIPGEKATQEELDAFYKRLGKPEAADKYSFDQKYEAEKRFAEAAFKANLSDKQAKELYDFFLNIGQSQQAQYKEIIVKKAQETDALLQKEYGNLFEQKIGNYTKALKLLGGGEVMKQLEETGLAYDPGFVKLMINAGEALGESKAVIGNGTTPNGIKSAREGGTFSFFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NM7</accession>
    <name>Q73NM7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971733.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670692.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1125"/>
    <dbReference type="EnsemblBacteria" id="AAS11614">
        <property type="protein sequence ID" value="AAS11614"/>
        <property type="gene ID" value="TDE_1125"/>
    </dbReference>
    <dbReference type="GeneID" id="2739541"/>
    <dbReference type="KEGG" id="tde:TDE_1125"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1086"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048872_0_0_12"/>
    <dbReference type="OMA" id="LITCAMV"/>
    <dbReference type="OrthoDB" id="734932at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="457" mass="52530" checksum="53FB87B59A083AE4" modified="2004-07-05" version="1">MSSLTIILIAAISAVLAFLIIFLLKSILFPKKRARIEKNLKSGKYGAAIKDAKSILSKNPRDSEARYLLGKAYLADKKVDLAFIEFKTLNKTAVFNNPATEIEFRTIIADLYLKFQQPDEALKEFMLLNKRDPKNPKPYFQAGQIYESKNMSDQAIAYFQKAIEVDSRFAEAYASLGLLLFKANQIPEAEKAIATALKLAPDNSETLYYHGKILKSKKNYAQALSALEKAARKQEIRSKCFFERGCCYLETNSLEKAEFEFTRAIKSSKQLSAPEVLYSRYLLADCYERQRNIDQAIEQWEAISAVNPKFRNTAQKLAEYSDLRTNDHMKEYLTLIKEEFFKMCRDITEQYFDYPVQALKETKMGCTILAVEKGSEQWLNTRKKPQLLIFSRDGHTITESFLRSVHEEMKKQAVVTSHIITSGAFSPDAIKFAENRPFNLIDRQKLERIVEKVKFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NN0</accession>
    <name>Q73NN0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971730.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670686.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1122"/>
    <dbReference type="EnsemblBacteria" id="AAS11611">
        <property type="protein sequence ID" value="AAS11611"/>
        <property type="gene ID" value="TDE_1122"/>
    </dbReference>
    <dbReference type="GeneID" id="2739538"/>
    <dbReference type="KEGG" id="tde:TDE_1122"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1082"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115403_9_3_12"/>
    <dbReference type="OMA" id="MNLAINI"/>
    <dbReference type="OrthoDB" id="1864829at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="112" mass="13015" checksum="A702E01D609FBCAF" modified="2004-07-05" version="1">MELKVRKNKEVYIIDVSGEMDLYNSYRLKELVMKMIERQIKCMIINLEDVDYIDSSGIGALIYICSTVKKMNLRLFITNIHGSVKKVIELTKLMGYFPITNSLEEALQKMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NN4</accession>
    <name>Q73NN4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Tyrosine phenol-lyase</fullName>
            <ecNumber evidence="5 9">4.1.99.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Beta-tyrosinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 12" type="primary">tpl</name>
        <name evidence="12" type="ordered locus">TDE_1118</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>H2O + L-tyrosine = NH4(+) + phenol + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21704"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15882"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="4.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the beta-eliminating lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.2" evidence="5 9"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971726.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682416.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73NN4"/>
    <dbReference type="STRING" id="243275.TDE_1118"/>
    <dbReference type="EnsemblBacteria" id="AAS11607">
        <property type="protein sequence ID" value="AAS11607"/>
        <property type="gene ID" value="TDE_1118"/>
    </dbReference>
    <dbReference type="GeneID" id="2739534"/>
    <dbReference type="KEGG" id="tde:TDE_1118"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1078"/>
    <dbReference type="eggNOG" id="COG3033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047223_0_0_12"/>
    <dbReference type="OMA" id="EMYQYGD"/>
    <dbReference type="OrthoDB" id="91973at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050371">
        <property type="term" value="F:tyrosine phenol-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00543">
        <property type="entry name" value="Tyr_phenol_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011166">
        <property type="entry name" value="Beta-eliminating_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018176">
        <property type="entry name" value="Tryptophanase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013441">
        <property type="entry name" value="Tyr_phenol_ly"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001386">
        <property type="entry name" value="Trpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02618">
        <property type="entry name" value="tyr_phenol_ly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00853">
        <property type="entry name" value="BETA_ELIM_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="11">
        <location>
            <begin position="49"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9 10">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611166-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS11607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="459" mass="51820" checksum="45A9122E4AB80721" modified="2004-07-05" version="1">MDIKNYPAEPFRIKVVETVKMIDKDQRAKVAKEAGYNTFLINSEDVYIDLLTDSGTNAMSDKQWAGMMIGDEAYAGSRNFHHLEETVQEIFGFKHLVPTHQGRGAENLLSRIAIKPGQYVPGNMYFTTTRYHQEANGGIFVDIINDDAHDAGKNVPFKGDIDLNKLEKLIKEKGAENIAYVCLAVTVNLAGGQPVSMKNMKAVRELTKKHGIKVFYDATRCVENAYFIKEQEAGYADKSIKEIVREMFSYADGCTMSGKKDCIVNIGGFLCMNDEDLFQAAKEFVVVFEGMPSYGGMAGRDMEAMAIGLKEALQFEYIEHRIKQVRYLGDKLLEAGVPIIEPVGGHAVFLDARRFCPHLKQTEFPAQALAAELYIESGVRSMERGIVSAGRDPKTRENHVPKLETVRLTIPRRVYTYKHMDIVADAVIKLYKHKEVIKGLKFVYEPKQLRFFTARFEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NN7</accession>
    <name>Q73NN7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971723.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670672.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1115"/>
    <dbReference type="EnsemblBacteria" id="AAS11604">
        <property type="protein sequence ID" value="AAS11604"/>
        <property type="gene ID" value="TDE_1115"/>
    </dbReference>
    <dbReference type="GeneID" id="2739531"/>
    <dbReference type="KEGG" id="tde:TDE_1115"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1075"/>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144725_3_2_12"/>
    <dbReference type="OMA" id="ESMTQMN"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="43"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="102" mass="11533" checksum="A822AFD559F1CFF2" modified="2004-07-05" version="1">MFKRKKMSDEMFAELLQSVKEAVLIEKGEIPPARVFEIEPLDIAKIRSKTNKTQEEFASMLNISIGTLRNWEQGRRKPDGAALSLLKIVSANPQYVESVLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NR9</accession>
    <name>Q73NR9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA pseudouridylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971691.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682394.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1083"/>
    <dbReference type="EnsemblBacteria" id="AAS11572">
        <property type="protein sequence ID" value="AAS11572"/>
        <property type="gene ID" value="TDE_1083"/>
    </dbReference>
    <dbReference type="GeneID" id="2739095"/>
    <dbReference type="KEGG" id="tde:TDE_1083"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_11_2_12"/>
    <dbReference type="OMA" id="RHQIRCH"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="261" mass="29543" checksum="C011B567D24D104D" modified="2004-07-05" version="1">MLIDCKFSSQAEVIFENEAYAVLYKPRGMPTAPLSEDEEGTLVSWFLKRCPEAVSVKGKKDIEAGLVHRLDTATSGLVLMAKNQESYDALNLMQGNDLIKKTYVAFTDIDNESDLNADFSRLNLPYRISSQFRSFGPKGKKVLPVFYGMRDFSSTAKIYTTNIIDINNLDDSVPRVTCTLTQGFRHQVRAHLASIGLPIYGDPLYNGKFKDFPQEKIEDHSYPLQLYAVGLSFPEPKRDFKLEDSKDYVSFLLQPPDKMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NT7</accession>
    <name>Q73NT7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971673.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682377.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1065"/>
    <dbReference type="EnsemblBacteria" id="AAS11554">
        <property type="protein sequence ID" value="AAS11554"/>
        <property type="gene ID" value="TDE_1065"/>
    </dbReference>
    <dbReference type="GeneID" id="2740826"/>
    <dbReference type="KEGG" id="tde:TDE_1065"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1025"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121336_1_0_12"/>
    <dbReference type="OMA" id="CFGCWIK"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="162" mass="18664" checksum="C6E8C77BC206B440" modified="2004-07-05" version="1">MKLIITDIENFNIPIKGEYKIIQPKKKIHHCIGCFGCWIKTPGKCVIHDGYEKTGIDMGNCSELILVSRCYYGSISPFVKKVQDRALSYIHPDFVIRKGKMHHKRRYKNIITMSSHLYGENITDIEKKTAEELLKANADNYDALVKGVYFYKDAKELDGVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NZ8</accession>
    <name>Q73NZ8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971611.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956859.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1002"/>
    <dbReference type="EnsemblBacteria" id="AAS11492">
        <property type="protein sequence ID" value="AAS11492"/>
        <property type="gene ID" value="TDE_1002"/>
    </dbReference>
    <dbReference type="GeneID" id="2739079"/>
    <dbReference type="KEGG" id="tde:TDE_1002"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.962"/>
    <dbReference type="eggNOG" id="COG0398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038944_5_0_12"/>
    <dbReference type="OMA" id="WVERHGF"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="230" mass="25362" checksum="B6BF6541E2324F6A" modified="2004-07-05" version="1">MKKRKLTDKWRKIITIGLIIFLLCLSIFLYFFWGQPLIKFLMDAEKVHAYVESHPFSSRIFFVTAVFLQVVVAVIPGCPFEIGAGYAFGAVEGALVSLAGISAAGILIFLFVKKFGKAAIEIFFSPEKIESIKIFKNKKRLHLIVFIVFLIPGTPKDLLTYMAGLTPIRLSEWLILSTLARFPAILASTIAGTSLAQKNTGLALAVFLIGSIAAFAGVLIFNKLNSRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P20</accession>
    <name>Q73P20_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-type D-Ala-D-Ala carboxypeptidase</fullName>
            <ecNumber evidence="4">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ordered locus">TDE_0979</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.4" evidence="4"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971589.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682292.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0979"/>
    <dbReference type="EnsemblBacteria" id="AAS11470">
        <property type="protein sequence ID" value="AAS11470"/>
        <property type="gene ID" value="TDE_0979"/>
    </dbReference>
    <dbReference type="GeneID" id="2740551"/>
    <dbReference type="KEGG" id="tde:TDE_0979"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.941"/>
    <dbReference type="eggNOG" id="COG1686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027070_8_1_12"/>
    <dbReference type="OMA" id="MANDFLA"/>
    <dbReference type="OrthoDB" id="1499212at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015956">
        <property type="entry name" value="Peniciliin-bd_prot_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012907">
        <property type="entry name" value="Peptidase_S11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037167">
        <property type="entry name" value="Peptidase_S11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07943">
        <property type="entry name" value="PBP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69189">
        <property type="entry name" value="SSF69189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="16">
        <location>
            <begin position="93"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="PBP5_C" evidence="17">
        <location>
            <begin position="363"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="12">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AAS11470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="478" mass="53748" checksum="8A5EBA063DA0F5E6" modified="2004-07-05" version="1">MKHSTNGIIKFIFVLFGAVLFCVLSLAGFIFFHVSELKKAQPLEVSQEEKTAALKTFYSRHKINKEFPPLNSIENFLPVKSSSSNIAPSAKKIELPKIDAESYILIHANTGTILAESNADKIIPPASLTKLVTIYTMLQKPQFKDLEKVVFPPEEAWAIFLPKGAAWMGLGENQSLSIEELIRGMAVCSGNDAALAAALLTEGSIEKFTLKMNEAVKTMGLKSTRFEDSSGLSEKNQTTARDFALFSLHYLKQYPENLKKFHSVNEISYPQKHNILIKKNSDGLKDFQIKPATNTLLKKIEGCDGLKTGFIYESGFNISLTAQKNGERFIAVILGGHGKNFTEGIFKREQNSIKLMNFAFDNFKSFDIREHNKIKRSVSVLSSNLNVKTSAFMPLLADEDFSQDYLTVFKNDERHIEQVIILPDVIRAPLFAGQQIGRIEYRIKDSDIVLKTIPLICPLDIKEGSSFRKFIDGFYRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P76</accession>
    <name>Q73P76_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_0923</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971533.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682224.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0923"/>
    <dbReference type="EnsemblBacteria" id="AAS11414">
        <property type="protein sequence ID" value="AAS11414"/>
        <property type="gene ID" value="TDE_0923"/>
    </dbReference>
    <dbReference type="GeneID" id="2740388"/>
    <dbReference type="KEGG" id="tde:TDE_0923"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.891"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_12"/>
    <dbReference type="OMA" id="TIMADCT"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="19"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="334"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="393"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS11414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="603" mass="66162" checksum="E2D28BAFBA61A58D" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PB2</accession>
    <name>Q73PB2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971497.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682163.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0887"/>
    <dbReference type="EnsemblBacteria" id="AAS11378">
        <property type="protein sequence ID" value="AAS11378"/>
        <property type="gene ID" value="TDE_0887"/>
    </dbReference>
    <dbReference type="GeneID" id="2739761"/>
    <dbReference type="KEGG" id="tde:TDE_0887"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.857"/>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124456_3_1_12"/>
    <dbReference type="OMA" id="ICAYWIT"/>
    <dbReference type="OrthoDB" id="2034229at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="139" mass="16005" checksum="CE6C0BF6212F09A0" modified="2004-07-05" version="1">MKKVLIDLNIILDFLNKRNFHEEAANIINMCVEKKLFGFIAAHEITTLSYFLLKEKKDKNKAADIISALLDMFNIIPIDEKILREALFSPVKDYEDAVIEVSSVKNSIDYIISRNLGDFKSARVQVFTPEQFFIKESNS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PB6</accession>
    <name>RIMM_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimM</name>
        <name type="ordered locus">TDE_0883</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971493.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670218.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PB6"/>
    <dbReference type="SMR" id="Q73PB6"/>
    <dbReference type="STRING" id="243275.TDE_0883"/>
    <dbReference type="EnsemblBacteria" id="AAS11374">
        <property type="protein sequence ID" value="AAS11374"/>
        <property type="gene ID" value="TDE_0883"/>
    </dbReference>
    <dbReference type="GeneID" id="2739757"/>
    <dbReference type="KEGG" id="tde:TDE_0883"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.853"/>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077636_3_2_12"/>
    <dbReference type="OMA" id="MFVKGII"/>
    <dbReference type="OrthoDB" id="1497415at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000163382" description="Ribosome maturation factor RimM">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PRC barrel" evidence="1">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <sequence length="179" mass="19977" checksum="FB239DDD49ACC54A" modified="2004-07-05" version="1">MDLLATGRIRGTFGIEGFVKVESFSGEYEHFLGFDRVFLSILKEKLREQKYKDGWFEIEEVNLRKADALVKFKGIDNPEAAKCLTGSELFIPRDKAAPLDEGEVYVHDLCNCNLVCEGTLVGKITSVAEGGGGYLLEIAGKTSEAAAESSFYVPFNKEFIGKIDLKAKTVELMHRWILE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PM0</accession>
    <name>RL5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplE</name>
        <name type="ordered locus">TDE_0779</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971389.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670018.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PM0"/>
    <dbReference type="SMR" id="Q73PM0"/>
    <dbReference type="STRING" id="243275.TDE_0779"/>
    <dbReference type="EnsemblBacteria" id="AAS11270">
        <property type="protein sequence ID" value="AAS11270"/>
        <property type="gene ID" value="TDE_0779"/>
    </dbReference>
    <dbReference type="GeneID" id="2740657"/>
    <dbReference type="KEGG" id="tde:TDE_0779"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.752"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_12"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="OrthoDB" id="1456375at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000125017" description="50S ribosomal protein L5">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <sequence length="183" mass="20623" checksum="FFD705C67133C7BC" modified="2004-07-05" version="1">MSNYVPRLKKVYTEQIMPELKKEFNYSSVMQIPRLKKVVVSMGVGVALTNRKLLDAAVTDLETITGQKAVKTKARKSIANFKLREGNEIGAMVTLRGARMYEFLDRFINVALPRVKDFRGVNPNGFDGRGNYSVGITEQIIFPEIDFDKIERISGLNVNVVTSAETDQEARSLLAKFGMPFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PN5</accession>
    <name>Q73PN5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971373.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0763"/>
    <dbReference type="EnsemblBacteria" id="AAS11254">
        <property type="protein sequence ID" value="AAS11254"/>
        <property type="gene ID" value="TDE_0763"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0763"/>
    <dbReference type="HOGENOM" id="CLU_3376600_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="34" mass="3774" checksum="0B388A5A1926C255" modified="2004-07-05" version="1">MSIGKFVLFIKKKSGEPKKCAALITHINVYGYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PS0</accession>
    <name>Q73PS0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldehyde oxidase and xanthine dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971338.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681965.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0726"/>
    <dbReference type="EnsemblBacteria" id="AAS11219">
        <property type="protein sequence ID" value="AAS11219"/>
        <property type="gene ID" value="TDE_0726"/>
    </dbReference>
    <dbReference type="GeneID" id="2740090"/>
    <dbReference type="KEGG" id="tde:TDE_0726"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.702"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_2_3_12"/>
    <dbReference type="OMA" id="GKRHGFH"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="695" mass="78089" checksum="4D2975C8C20594DD" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PT0</accession>
    <name>Q73PT0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAAX amino terminal protease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971328.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956802.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0716"/>
    <dbReference type="EnsemblBacteria" id="AAS11209">
        <property type="protein sequence ID" value="AAS11209"/>
        <property type="gene ID" value="TDE_0716"/>
    </dbReference>
    <dbReference type="GeneID" id="2740623"/>
    <dbReference type="KEGG" id="tde:TDE_0716"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.693"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084787_0_0_12"/>
    <dbReference type="OrthoDB" id="1623593at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="278" mass="32571" checksum="2B71E72FC46D40A1" modified="2004-07-05" version="1">MPYNKKKVLAVFYWFISIIIEAFIAFFILDLIYVYVFMYKEEYWYIILAIGYTELGIAIITFKRFKENKNLLQFKPFKFSTVIKIYFIGIIITTLIAWIFRGFGNFKNMIESSVIYFLNRFTGKESFTVRTIFNTNFIYKPLIIYEFVAALIIAPIYEELIFRGVIYDDTKKLFNAKIAALVSSILFGLIHLYGGYAQVIGTIVSGLLSAYCYEKTKSLYACIFLHSLHNFIAVVMRRLLNWQTYVILILIFTPACIIMLIAEGIRYFGRRKALIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PY0</accession>
    <name>Q73PY0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pyruvate ferredoxin/flavodoxin oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">TDE_0665</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971278.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681868.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0665"/>
    <dbReference type="EnsemblBacteria" id="AAS11159">
        <property type="protein sequence ID" value="AAS11159"/>
        <property type="gene ID" value="TDE_0665"/>
    </dbReference>
    <dbReference type="GeneID" id="2739213"/>
    <dbReference type="KEGG" id="tde:TDE_0665"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.646"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002569_0_0_12"/>
    <dbReference type="OrthoDB" id="10483at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:electron transport chain"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
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        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pyrv_flavodox_OxRed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
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        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
        <property type="entry name" value="EKR"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF17147">
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    </dbReference>
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        <property type="entry name" value="POR"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01855">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000159">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00890">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02176">
        <property type="entry name" value="pyruv_ox_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="688"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="744"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="979"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="1008"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="697"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="707"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="753"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
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            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="756"/>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="759"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="763"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="12">
        <location>
            <position position="828"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="831"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="833"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="856"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1088"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
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    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="66"/>
        </location>
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    <feature type="site" description="Important for catalytic activity" evidence="11">
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        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="1013"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAS11159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1186" mass="130678" checksum="D5CFCC921E903FB5" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PZ4</accession>
    <name>Q73PZ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971264.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681843.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0650"/>
    <dbReference type="EnsemblBacteria" id="AAS11145">
        <property type="protein sequence ID" value="AAS11145"/>
        <property type="gene ID" value="TDE_0650"/>
    </dbReference>
    <dbReference type="GeneID" id="2740481"/>
    <dbReference type="KEGG" id="tde:TDE_0650"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.629"/>
    <dbReference type="eggNOG" id="COG3641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063648_0_0_12"/>
    <dbReference type="OMA" id="MLQVPNI"/>
    <dbReference type="OrthoDB" id="814081at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008982">
        <property type="term" value="F:protein-N(PI)-phosphohistidine-sugar phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003352">
        <property type="entry name" value="PTS_EIIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13303">
        <property type="entry name" value="PTS_EIIC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="PTS_EIIC" evidence="9">
        <location>
            <begin position="23"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="344" mass="36296" checksum="5E956D461DF922CA" modified="2004-07-05" version="1">MNNSFKNFLTKKNIEISARRYFIDAMSAMAMGLFSSLLVGTILNSIGLKLNIPFLTKTVWPICRDMTGAAIGIAIAHALKAHTFVLFSATIVGFAGNKLGGPVGAFIATIISTELGKAVSRETKIDLIVTPMVTIISGTIIAALVGPGMSSFMTWLGKIIMDATTLQPFWMGVTVSVLVGVILTLPISSAAICMMLSLAGLAGGAATVGCAAQMIGFAVMSYRDNGLGGSFAVGIGTSMLHMPNIIKNPRIWIPPTLTAAVLGPLATIIFKMENIPLGSGMGTCGLVGQIGTITAMESIGRGGLNTYFAIFLLHFILPAVLTLFFTFILRKINWIKDGDLKLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q00</accession>
    <name>Q73Q00_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971258.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681841.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0644"/>
    <dbReference type="EnsemblBacteria" id="AAS11139">
        <property type="protein sequence ID" value="AAS11139"/>
        <property type="gene ID" value="TDE_0644"/>
    </dbReference>
    <dbReference type="GeneID" id="2740475"/>
    <dbReference type="KEGG" id="tde:TDE_0644"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.623"/>
    <dbReference type="eggNOG" id="COG1137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="LPMYQRA"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="245" mass="27759" checksum="93451E8763300603" modified="2004-07-05" version="1">MIDKKSILKVEGLNKFFRKKHAVKDVGFSMYQGEIVGLLGPNGAGKTTTFYMIVGFYKPNSGNIYLDGNRITNLPMYKRAHAGISYLPQEASVFRKLTVEQNIYAILETRKDLSKEQKMERLEFLLEEFGITANRKQQAYTLSGGERRRTEIARALAIEPKFLLLDEPFAGIDPIAVHDIKSIVRILADQGIGILITDHNVRDTLEITDRAYIIGSGEIVEQGSRDEILNSEIARKIYLGQEFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q67</accession>
    <name>Q73Q67_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamyl-tRNA(Gln) amidotransferase, C subunit</fullName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name evidence="1" type="ordered locus">TDE_0577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971191.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002665812.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0577"/>
    <dbReference type="EnsemblBacteria" id="AAS11072">
        <property type="protein sequence ID" value="AAS11072"/>
        <property type="gene ID" value="TDE_0577"/>
    </dbReference>
    <dbReference type="GeneID" id="2741013"/>
    <dbReference type="KEGG" id="tde:TDE_0577"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.560"/>
    <dbReference type="eggNOG" id="COG0721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105899_3_0_12"/>
    <dbReference type="OMA" id="DDSENPY"/>
    <dbReference type="OrthoDB" id="1780195at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="103" mass="11610" checksum="3919737CF9E40601" modified="2004-07-05" version="1">MEKNNNKISKEVFSTLLYLSRLSLGEQEEARLSGQVNNLVGYFEILDKFADSSLDSSMYAKHSETDLRSSEVKEGLAQSDLKKMTSEYMDNYFRVPKVLGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q83</accession>
    <name>Q73Q83_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971174.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0560"/>
    <dbReference type="EnsemblBacteria" id="AAS11055">
        <property type="protein sequence ID" value="AAS11055"/>
        <property type="gene ID" value="TDE_0560"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0560"/>
    <dbReference type="HOGENOM" id="CLU_3395689_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="31" mass="3642" checksum="C483097102C729F7" modified="2004-07-05" version="1">MGMFENLLMINFQIMNDLKIEIVVKDRICAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q92</accession>
    <name>Q73Q92_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971165.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681712.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0551"/>
    <dbReference type="EnsemblBacteria" id="AAS11046">
        <property type="protein sequence ID" value="AAS11046"/>
        <property type="gene ID" value="TDE_0551"/>
    </dbReference>
    <dbReference type="GeneID" id="2740539"/>
    <dbReference type="KEGG" id="tde:TDE_0551"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.536"/>
    <dbReference type="eggNOG" id="ENOG502ZBQV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1309027_0_0_12"/>
    <dbReference type="OrthoDB" id="1424111at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="176" mass="20751" checksum="3D1B57590485D2E9" modified="2004-07-05" version="1">MDKRIIDRITKLGGKSAFESENLLRNMESISLSKSYLMQDFSDYLENDLLDRIKAEGILPESEIPYPRIQYKTEKFTPFTKGTADYDEYSGFIHKEYVSSVIPCNDLEFLIIGESNSYPNYYFICLSDKDISNPKVYTTDHEVFFREIEELGRFSDFLNLFVSEDEYKVEMNRLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QC9</accession>
    <name>Q73QC9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971128.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681645.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0514"/>
    <dbReference type="EnsemblBacteria" id="AAS11009">
        <property type="protein sequence ID" value="AAS11009"/>
        <property type="gene ID" value="TDE_0514"/>
    </dbReference>
    <dbReference type="GeneID" id="2739611"/>
    <dbReference type="KEGG" id="tde:TDE_0514"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.500"/>
    <dbReference type="eggNOG" id="ENOG5032CFQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2208882_0_0_12"/>
    <dbReference type="OrthoDB" id="1854150at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="107" mass="12703" checksum="63B3000E50B95293" modified="2004-07-05" version="1">MNEEILNTVYSASLEFGENFHKPIIDIVAELYPYIPDDEKTAIADYIGQTRDAIEQYFYDKYDYKNETANKQLQHQGKQWIENKYCWMNSENVNRAAAQGMYYAWHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QG3</accession>
    <name>Q73QG3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-L-fucosidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971094.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681576.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0480"/>
    <dbReference type="CAZy" id="GH29">
        <property type="family name" value="Glycoside Hydrolase Family 29"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10975">
        <property type="protein sequence ID" value="AAS10975"/>
        <property type="gene ID" value="TDE_0480"/>
    </dbReference>
    <dbReference type="GeneID" id="2740527"/>
    <dbReference type="KEGG" id="tde:TDE_0480"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.465"/>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_0_0_12"/>
    <dbReference type="OMA" id="RSIYGCT"/>
    <dbReference type="OrthoDB" id="439010at2"/>
    <dbReference type="BRENDA" id="3.2.1.51">
        <property type="organism ID" value="6426"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="478" mass="54593" checksum="C3F9D1DF5A1A6451" modified="2004-07-05" version="1">MLNFCCFKPIFAHLKSLILSYILNIMKPDKITQWQKLGFGMFIHYGLYSLCGGVWKGEPVKRGYSEQILSHGKIPKEEYKALQNKFTCKNFDAGKICALAKAAGMKYIIITAKHHDGFCLFDTKTTDYNSVKAPAKRDLIAELSQACKKNGLRFGLYFSWIDWNCEFALPISDHNSDKIPPKHQKVNIEQLKELFTNYGPLCELWMDMGYPTKKQSEEVRALAQKLQPDMMINGRIWNDCGDFCTMGDNKFPDKSLNVPWQTPASIYHETWGYRSWQRRGDKNKKAQELIESLIRVRAMGGNYLLNIGPKGDGSVVAFEAEVLKKIGSFFKSKAPSQGCAKKLCKELNLDIPQDSILELSGEKNEIPFTKKLYRFTGKDYYSSHFICTELELNLKISKGLYKTNFWTISLVRKKPLSQDEVLEINGKEFCFPANKKELEIFKNIKIESVLKISVSTGGTPSLRKALKQDNLILRVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QG4</accession>
    <name>Q73QG4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydroxylamine reductase</fullName>
            <ecNumber evidence="6">1.7.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Hybrid-cluster protein</fullName>
            <shortName evidence="6">HCP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Prismane protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hcp</name>
        <name evidence="7" type="ordered locus">TDE_0479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine</text>
            <dbReference type="Rhea" id="RHEA:22052"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15429"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="1.7.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </cofactor>
        <text evidence="6">Binds 1 hybrid [4Fe-2O-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HCP family.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.1" evidence="6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971093.2">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681572.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0479"/>
    <dbReference type="EnsemblBacteria" id="AAS10974">
        <property type="protein sequence ID" value="AAS10974"/>
        <property type="gene ID" value="TDE_0479"/>
    </dbReference>
    <dbReference type="GeneID" id="2740526"/>
    <dbReference type="KEGG" id="tde:TDE_0479"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.464"/>
    <dbReference type="eggNOG" id="COG1151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038344_2_0_12"/>
    <dbReference type="OMA" id="CAYAQGM"/>
    <dbReference type="OrthoDB" id="337713at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050418">
        <property type="term" value="F:hydroxylamine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01914">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00069">
        <property type="entry name" value="Hydroxylam_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010048">
        <property type="entry name" value="Hydroxylam_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016100">
        <property type="entry name" value="Prismane_a-bundle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109:SF0">
        <property type="entry name" value="PTHR30109:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000076">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01703">
        <property type="entry name" value="hybrid_clust"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="6">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine persulfide" evidence="6">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS10974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="543" mass="59783" checksum="B1F17F15F12B6E3E" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QT0</accession>
    <name>Q73QT0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970977.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681368.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0363"/>
    <dbReference type="EnsemblBacteria" id="AAS10858">
        <property type="protein sequence ID" value="AAS10858"/>
        <property type="gene ID" value="TDE_0363"/>
    </dbReference>
    <dbReference type="GeneID" id="2741083"/>
    <dbReference type="KEGG" id="tde:TDE_0363"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.353"/>
    <dbReference type="eggNOG" id="COG2452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128104_0_0_12"/>
    <dbReference type="OrthoDB" id="1701087at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="147" mass="17659" checksum="F2FBA6E47AA12D80" modified="2004-07-05" version="1">MEKLYTMNQIAEMLELSVRTIQNYLKEGKLTGKKIGSQWRFTEKDLERLFSDESFIDEKNIDENHRLQEFLKKDSVNKPEIFSILNYPYKKDFKLKELMKKINENIEKANKCRFYFASTANTFKFFLEGDIESVINLQKIIDENFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QT5</accession>
    <name>Q73QT5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cinnamoyl ester hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cinI</name>
        <name evidence="3" type="ordered locus">TDE_0358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970972.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681345.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0358"/>
    <dbReference type="ESTHER" id="trede-q73qt5">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10853">
        <property type="protein sequence ID" value="AAS10853"/>
        <property type="gene ID" value="TDE_0358"/>
    </dbReference>
    <dbReference type="GeneID" id="2740165"/>
    <dbReference type="KEGG" id="tde:TDE_0358"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.347"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048353_1_0_12"/>
    <dbReference type="OMA" id="WSAVGYP"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285907" evidence="1">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="57"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="281" mass="30891" checksum="3CF535F1064472E0" modified="2004-07-05" version="1">MKKIMLLSAAILFIGITAAAQTKAAAHTFKVEEQSFQRNGMKIYGKLFLPDSVSPVPLVILSHGFGGNHSGVKGYAAAFAEHGIAAYIFDFIGGGNHIKSDGKMTEMSVLTEAEDLTVILDNLKADSRFKPEQIFLLGESQGGFVSTYIAALRPDDIAGLALLYPAFVLHDYVRRRTPDPERIPDTMKLLGKTIGRIYNKDVLSFDIYTLMPRYSGKTLIIHGTADSLVPLSYSERAVKTFPNAKLIKLDGAKHVFYGDMMQKAAEDAVKFVQSIIDEKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QV1</accession>
    <name>Q73QV1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mviN</name>
        <name evidence="8" type="synonym">murJ</name>
        <name evidence="10" type="ordered locus">TDE_0342</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the MurJ/MviN family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970956.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0342"/>
    <dbReference type="EnsemblBacteria" id="AAS10837">
        <property type="protein sequence ID" value="AAS10837"/>
        <property type="gene ID" value="TDE_0342"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0342"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.331"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006797_5_0_12"/>
    <dbReference type="OMA" id="IFFVAFK"/>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 8 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="537" mass="58353" checksum="A36CA419BFAFA649" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QY0</accession>
    <name>Q73QY0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TrkA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970927.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666331.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0313"/>
    <dbReference type="EnsemblBacteria" id="AAS10808">
        <property type="protein sequence ID" value="AAS10808"/>
        <property type="gene ID" value="TDE_0313"/>
    </dbReference>
    <dbReference type="GeneID" id="2740512"/>
    <dbReference type="KEGG" id="tde:TDE_0313"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.302"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_3_2_12"/>
    <dbReference type="OMA" id="PEYEAGC"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="127"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
    <sequence length="230" mass="25283" checksum="E7F27E424920B4BA" modified="2004-07-05" version="1">METNKNFAVIGLGEFGSRICEVLVDGGASVVAFDHDIQAVERIKKIVPAAMLVETTNEEALLKAPLDDVEVAIVAIGNNIEASVLTTTLLKQRDIPYVLARAVSPLHATVLRRVGANEVLNIEISAATRIARRLISPDVMDSIAVTKDFSIREIIVPKFFIGKTVGSVALKEKFNITLIALVRMALDIDSVGNPVKQEVMHYPEDDFELREGDKLFLIGSNIKLEEFRNM</sequence>
</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="221" mass="24886" checksum="C2115F651E66F6E5" modified="2004-07-05" version="1">MHNGISIGKGILWVLVWFGFMILYTILDVSIWRKIAPEHSRVLNIITVILCMTIFLALLMRKTNFRPNLFTNISFQGLILAVGCSILFYFLLDKGLDPIFESFFPSSRENYQQTIQSIRAAPIIGLLDFCILAPILEEILMRGFLLEGLSINYGKIVALLISAALFAMLHFNIAQIVPSFICGVILGLLYFHTGSIFSCILAHMGYNLIAYSVIVLPIYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R19</accession>
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        </submittedName>
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    <organism evidence="10 11">
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
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                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
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                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
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                <person name="Smajs D."/>
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                <person name="Pal S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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    </evidence>
    <sequence length="597" mass="65091" checksum="240114CBBE65B70B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
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            </authorList>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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        </source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
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                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
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                <person name="Selengut J."/>
                <person name="Ren Q."/>
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                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
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                <person name="McLeod M.P."/>
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                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
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                <person name="Sodergren E."/>
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                <person name="Weinstock G.M."/>
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        </source>
    </evidence>
    <sequence length="451" mass="46562" checksum="B58006C1CD34EA61" modified="2004-07-05" version="1">MQGIALIITFVIAIALMIFAISKLKIHPFLSIMGVSLLLALAAGIPLVKIPGTIGAGFSGTFTSIGIVIILGALIGTILEKTGAALKLSDMVIKVVGKKHPELAMLIMGWIVSIPVFCDSGFVILNPIRKALVQRTRISSVAMTVALSAGLYISHVFIPPTPGPIAAASSLGIGNNLLLVIGMGALASIFPLIAGYFFARYIGTKVKASEDSSTDEVSQSYEELVASYGSLPNGFTAIAPIIVPILLMALSSVASMANMSGTGADILKFLGAPIMALAVGLIFGVILFASQKKTEDFYILTNETLKVVGPILFVTAAGGVLGKVIASSSLVGYITEHAAVLKTVGIFFPFLLAAILKSAQGSSTVAITTTAGILAPLMAPLGLATIPLSALTVMAIGAGAMTVSHANDSYFWVVTTFGGLKAEDGYKTQTLMTLVIGIAAIIGIFIISLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RH1</accession>
    <name>Q73RH1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970734.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680975.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0117"/>
    <dbReference type="EnsemblBacteria" id="AAS10615">
        <property type="protein sequence ID" value="AAS10615"/>
        <property type="gene ID" value="TDE_0117"/>
    </dbReference>
    <dbReference type="GeneID" id="2741732"/>
    <dbReference type="KEGG" id="tde:TDE_0117"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.117"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072078_0_0_12"/>
    <dbReference type="OMA" id="FYNIDIV"/>
    <dbReference type="OrthoDB" id="1488681at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="304" mass="34804" checksum="F88A67D38382C472" modified="2004-07-05" version="1">MKSINFMKICLFVFFVLFLTSCSSIQKNWKTDGSTIEKDIALSKKQGLMFFSASDTDPQSKNLLENVFTDSLFSKINKDFIFYNIDIVKEAGSADSVQLEKNYILFSDYNITQVPYLCLINEHGDVYHSDLIPEQINTPSSFLDHLNKLKEKRLTVENLRKNINEVNGPEKIKAINAFFEKIYLVDSEKYRQFFDEGIASDPSNESGLVGSFLLARTSLNIEPLFKQQKYTEIIAELKKILETGFLSPEEEQLTLCNIASFYSRLPNAPIKTILGYLEEALKKAPNSFRAKTIKEDIEYLKAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RI7</accession>
    <name>Q73RI7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-amylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970718.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680950.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73RI7"/>
    <dbReference type="STRING" id="243275.TDE_0101"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10599">
        <property type="protein sequence ID" value="AAS10599"/>
        <property type="gene ID" value="TDE_0101"/>
    </dbReference>
    <dbReference type="GeneID" id="2741716"/>
    <dbReference type="KEGG" id="tde:TDE_0101"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.101"/>
    <dbReference type="eggNOG" id="COG1523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011725_1_1_12"/>
    <dbReference type="OMA" id="SEPWDCG"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004133">
        <property type="term" value="F:glycogen debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02856">
        <property type="entry name" value="E_set_GDE_Isoamylase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044505">
        <property type="entry name" value="GlgX_Isoamylase_N_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011837">
        <property type="entry name" value="Glycogen_debranch_GlgX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02100">
        <property type="entry name" value="glgX_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="3">
        <location>
            <begin position="174"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="714" mass="81610" checksum="F3CB2D7B9E805B13" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RJ8</accession>
    <name>Q73RJ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970707.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673255.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0090"/>
    <dbReference type="EnsemblBacteria" id="AAS10588">
        <property type="protein sequence ID" value="AAS10588"/>
        <property type="gene ID" value="TDE_0090"/>
    </dbReference>
    <dbReference type="GeneID" id="2741705"/>
    <dbReference type="KEGG" id="tde:TDE_0090"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.91"/>
    <dbReference type="eggNOG" id="COG5662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1260992_0_0_12"/>
    <dbReference type="OrthoDB" id="1340815at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="220" mass="24657" checksum="51DEFA27714F734A" modified="2004-07-05" version="1">MSTCPDKDLYSAYVDGELQSPWKEKIEVHLVSCEKCRSVVDSYRKISLKLSENSFPEPDLDGSFLKLYAKRQDCLKKMEFNKSKPTSWFYKSNKIPIPALAAAALFLFVLTPIIVLSTQESLEPSGAVAATEFKAIDSIINGLKPVNKFKLNVSNVLGVNEDVSVFEGKKKEINLSQYVNLYLPPSNNAEFDILKQEIKPQVLFLNTQNAITRTSVNNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RK3</accession>
    <name>Q73RK3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TDE_0085</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
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    <dbReference type="EnsemblBacteria" id="AAS10583">
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    </dbReference>
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    <dbReference type="KEGG" id="tde:TDE_0085"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.86"/>
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    <dbReference type="OMA" id="QSFIVQA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="UVRD_HELICASE_CTER"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
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    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
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    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="10">
        <location>
            <begin position="9"/>
            <end position="435"/>
        </location>
    </feature>
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            <end position="752"/>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AAS10583.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1139" mass="130986" checksum="C3DC419436C9942B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="AAS10575.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="436" mass="48591" checksum="FD53FB669C3A8D4C" modified="2004-07-05" version="1">MVLIRQYFDVKDVKFGDKCCFSDGILTISEDELNEVAKDLFNAVKGFRLEITHPGENARIIHVLDTLASMVKLEGEGQQYSGFFGTPFTVGRGITNIFSGFSVMESADLPWDETNASSGLLYPRDAIIEIAGDYAQYTPFSEMHNLVIVYDLNEGKSAMEYDNDIRLIAIKISTYLAELTRTLKPDRTETFQTLQNNSSLPNVVLVWQCQNQGPYANTFLYGLPIYDIVPTILHPNEMLDGCIVSGNYVWPAFKVPTYLHVNHPILLDLYRRHGKDLWFKGVILCRSHNPSNWHKQRCASHCVKLAQMLKADGLVMAWEGGGNACVDGMYTIQTAENHGIMASTITFEFGGKDGTEGVLLVDHFPEADAVCTGGSIEKPVYLKQVKRVVGGDTFRLNKESGGFFPPSNNELVLDNTTHLYLGGNQCGYSKIFAEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RM8</accession>
    <name>Q73RM8_TREDE</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS10558"/>
        <property type="gene ID" value="TDE_0060"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG5032J33">
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="103" mass="11852" checksum="17E93C45E39629B3" modified="2004-07-05" version="1">MIRLRISHFDKLQREKLLKVFISFSDKRNMNSPDFFYVIKNVVLSPIVIGVTIVCGLILSFIFYVMSYKKKPRRFAVKKKAPKPGKEKTPASKEEAAGEEGEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RN8</accession>
    <name>HUTI_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazolonepropionase</fullName>
            <ecNumber evidence="1">3.5.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Imidazolone-5-propionate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hutI</name>
        <name type="ordered locus">TDE_0047</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23660"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
            <dbReference type="EC" id="3.5.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc or iron ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. HutI family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.7" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970664.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673322.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73RN8"/>
    <dbReference type="SMR" id="Q73RN8"/>
    <dbReference type="STRING" id="243275.TDE_0047"/>
    <dbReference type="EnsemblBacteria" id="AAS10545">
        <property type="protein sequence ID" value="AAS10545"/>
        <property type="gene ID" value="TDE_0047"/>
    </dbReference>
    <dbReference type="GeneID" id="2741662"/>
    <dbReference type="KEGG" id="tde:TDE_0047"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.49"/>
    <dbReference type="eggNOG" id="COG1228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041647_0_1_12"/>
    <dbReference type="OMA" id="CAPHARW"/>
    <dbReference type="OrthoDB" id="785930at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00551"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050480">
        <property type="term" value="F:imidazolonepropionase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01296">
        <property type="entry name" value="Imidazolone-5PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00372">
        <property type="entry name" value="HutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005920">
        <property type="entry name" value="HutI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42752">
        <property type="entry name" value="PTHR42752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01224">
        <property type="entry name" value="hutI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0369">Histidine metabolism</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000455446" description="Imidazolonepropionase">
        <location>
            <begin position="1"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>N-formimidoyl-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58928"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>4-imidazolone-5-propanoate</name>
            <dbReference type="ChEBI" id="CHEBI:77893"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00372"/>
        </source>
    </evidence>
    <sequence length="413" mass="45099" checksum="757A5A05DE747E5E" modified="2004-07-05" version="1">MTLFISDSIFSSTEKKGVDFDKAFAGYIVVENGLIQKVGKGDAPESLKSQAEKIIDARGKTITAGLVDAHTHLVHGGSREHELAMKLAGKTYLEIHASGGGIFSTVRATRAASKEELTQKALTSLDRMLIHGTTTAESKSGYGLDMETEIKCLEINSYLNKNHPIDIVSTYMGAHATPPEFKDNKEGYIKFMIEEVMPEVKKRGLAEFSDAFCEDKIFSVEETERIMKAAADLGFKLKLHADEIIPLKGAELAAKMNAHSAEHLMAISDEGITALAKSGTVAVLLPATSFFLMSPIYAPAKKMIEEGVRVALATDYNPGSSPTENLQMAMWAACYKMKLLPAQILRGVTINAAYAIDREKTIGSIEEGKQADLVIFDAPNIDFLVYHFGVNSVDQVWKKGKLVAEKGRLVYKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-06-07" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>P61672</accession>
    <name>MUTS_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mutS</name>
        <name type="ordered locus">TDE_2603</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973201.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61672"/>
    <dbReference type="SMR" id="P61672"/>
    <dbReference type="STRING" id="243275.TDE_2603"/>
    <dbReference type="EnsemblBacteria" id="AAS13120">
        <property type="protein sequence ID" value="AAS13120"/>
        <property type="gene ID" value="TDE_2603"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2603"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2461"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_3_1_12"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="OrthoDB" id="15991at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000115162" description="DNA mismatch repair protein MutS">
        <location>
            <begin position="1"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="827"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="827"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="639"/>
            <end position="646"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="891" mass="99926" checksum="A7BC6F5BD76823D7" modified="2004-06-07" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-06-21" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>P62031</accession>
    <name>GCSPB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable glycine dehydrogenase (decarboxylating) subunit 2</fullName>
            <ecNumber evidence="1">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycine cleavage system P-protein subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycine decarboxylase subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycine dehydrogenase (aminomethyl-transferring) subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gcvPB</name>
        <name type="ordered locus">TDE_1624</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvP family. C-terminal subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972230.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679310.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P62031"/>
    <dbReference type="SMR" id="P62031"/>
    <dbReference type="STRING" id="243275.TDE_1624"/>
    <dbReference type="PRIDE" id="P62031"/>
    <dbReference type="EnsemblBacteria" id="AAS12141">
        <property type="protein sequence ID" value="AAS12141"/>
        <property type="gene ID" value="TDE_1624"/>
    </dbReference>
    <dbReference type="GeneID" id="2740865"/>
    <dbReference type="KEGG" id="tde:TDE_1624"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1552"/>
    <dbReference type="eggNOG" id="COG1003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_5_0_12"/>
    <dbReference type="OMA" id="MHINLHK"/>
    <dbReference type="OrthoDB" id="70707at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00713">
        <property type="entry name" value="GcvPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023012">
        <property type="entry name" value="GcvPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000167024" description="Probable glycine dehydrogenase (decarboxylating) subunit 2">
        <location>
            <begin position="1"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00713"/>
        </source>
    </evidence>
    <sequence length="482" mass="53417" checksum="122CC637802FC530" modified="2004-06-21" version="1">MSELIFEKSVKGHKFAEAKLTVPEYKLDSKYLRASDAKLPEVSELEFVRHYMELSKRTHGVDNGFYPLGSCTMKYNPKLNEEVADLPNFTNIHPLQPEHTMKGCIEAMGDLGKKLGEITGMDAFSLQPSAGAHGEFTALLVIRAYHEKRGDHARNKILVPDSAHGTNPASAAMVGCEIVNIPSDKDGNVDIEELKKTVGNDTAALMLTNPNTLGLFETHIKEIAEIVHKAGGLLYYDGANLNAIMGRLRPGDMGYDIVHLNLHKTFSTPHGGGGPGSGPIGCKKFLEEFLPVPVVTGSDGSYKLDYNRPDSIGRVRNFYGNFLVFLRAYAYILTLGSEGIRESSGYAVLNANYLKKKLEKEYDVAFDRICMHEFVLTLEKIKEETGVSALDIAKGLIDDGIHPPTMYFPLIVHEALMFEPTETESKSTLDFTAEVMIKLKKEAYSNPEKLHGYPYTRPIGRVDETKAAREPVLRYKACCCCK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-05" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>P62239</accession>
    <name>RS16_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsP</name>
        <name type="ordered locus">TDE_0881</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971491.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670213.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P62239"/>
    <dbReference type="SMR" id="P62239"/>
    <dbReference type="STRING" id="243275.TDE_0881"/>
    <dbReference type="EnsemblBacteria" id="AAS11372">
        <property type="protein sequence ID" value="AAS11372"/>
        <property type="gene ID" value="TDE_0881"/>
    </dbReference>
    <dbReference type="GeneID" id="2740928"/>
    <dbReference type="KEGG" id="tde:TDE_0881"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.851"/>
    <dbReference type="eggNOG" id="COG0228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_5_0_12"/>
    <dbReference type="OMA" id="GFYNPIA"/>
    <dbReference type="OrthoDB" id="1937072at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000167273" description="30S ribosomal protein S16">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <sequence length="81" mass="9524" checksum="0ADFF12C5616BE29" modified="2004-07-05" version="1">MVKIRLKRLGTKKRPYYRIVVQDVREPRNGKTIDEVGIYHPIETAEKQISFDADKVRNWLGKGAQPTDTVRRLLNKKEFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J18</accession>
    <name>Q73J18_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973356.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680824.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2758"/>
    <dbReference type="EnsemblBacteria" id="AAS13275">
        <property type="protein sequence ID" value="AAS13275"/>
        <property type="gene ID" value="TDE_2758"/>
    </dbReference>
    <dbReference type="GeneID" id="2740725"/>
    <dbReference type="KEGG" id="tde:TDE_2758"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2602"/>
    <dbReference type="eggNOG" id="COG2361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_3_3_12"/>
    <dbReference type="OMA" id="RHAYHAT"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="118" mass="14072" checksum="AE95D5C175CB7784" modified="2004-07-05" version="1">MYRSNEELFKHIFDEIVFLESETRTISKEVFLKDEKTQRAFARSIEIIGEAVKNISNDIIIKYKEVPWRNIAGMRDKLIHGYFSVDYEIVWDVAKNIIPEFKNQLIKIMDTEKKKNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J48</accession>
    <name>Q73J48_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973326.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13245">
        <property type="protein sequence ID" value="AAS13245"/>
        <property type="gene ID" value="TDE_2728"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2728"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2576"/>
    <dbReference type="HOGENOM" id="CLU_3259299_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="42" mass="4794" checksum="E64FABC651CF179C" modified="2004-07-05" version="1">MQKKYPTVVTAKNKRQRIRILTVAASQAKSFKLLGSYNSYCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JB6</accession>
    <name>Q73JB6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF domain/HD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973257.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673537.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2659"/>
    <dbReference type="EnsemblBacteria" id="AAS13176">
        <property type="protein sequence ID" value="AAS13176"/>
        <property type="gene ID" value="TDE_2659"/>
    </dbReference>
    <dbReference type="GeneID" id="2741104"/>
    <dbReference type="KEGG" id="tde:TDE_2659"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2513"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_13_12"/>
    <dbReference type="OMA" id="VEIYDRW"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="191"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="417" mass="46842" checksum="D2B9C9DE20C32475" modified="2004-07-05" version="1">MTEKNKYKELSKEQILIKILETESLIHSVQDVDVLLEQILTEARSVVNADAGSIYIAEGDRLAIRYAQNDTLQKKRPAGTKLPYIFFDFPIDNYTIAGYAANTKKLINIPDVYNIDADKPFKFGKATDEKTGYKTVSNLTIPILSMSGMLLGVLQVLNALDKYGKPKTFSHDDEIYLSHFASNAGIALEHAFVTRAMVMRMIKTAELRDPRETGMHVNRVANYSVEIYDRWAFNNGIPMAEQTKYRDSLKIASMLHDIGKVAISDLILKKAGKLTDEEFSVMKTHTWLGARLFSGNDSPLDKLSMEIALRHHENWDGTGYPGHIDIETGEALKTDKKTGCPQGLKGEEIPLGARIVAIADVYDALSSKRSYKDSWTEEDILKELKKMSGKKFDPEIAKAFFEVLDRIQAIKAHLADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JD5</accession>
    <name>Q73JD5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973238.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680667.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2640"/>
    <dbReference type="EnsemblBacteria" id="AAS13157">
        <property type="protein sequence ID" value="AAS13157"/>
        <property type="gene ID" value="TDE_2640"/>
    </dbReference>
    <dbReference type="GeneID" id="2740814"/>
    <dbReference type="KEGG" id="tde:TDE_2640"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2496"/>
    <dbReference type="eggNOG" id="ENOG5031CFX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_911966_0_0_12"/>
    <dbReference type="OMA" id="NVRIFFT"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="68"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="305" mass="34409" checksum="C15FEA86B581A075" modified="2004-07-05" version="1">MIKENEDKLLNSDLFKAFLKKDLNRCDFISQWLSAHNVPHSIVNLAQKKHIIVKYPAQFYDKNFKMKTLTAHYDRTPDTQGANDNSASCFILMNFAKKLCSYTSPHNIKIIFTDGEEAGAEGLKEQGAYTLGTGLKKLKMDGDDIFVFDMCGRGDTLILSRSGIFGRDKAKTKRLDELHKRAGLLAQRACPNQWLSMLTAYSDNAGFIAAGLFAQVITLLPRKEAETLLHCLPKEKLTGQNKTAMSELTDMVIKNQKPPQGSPFEKIIPFTWQLMHTADDKIETLNSEAFTLTEKYLTALAENYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JJ6</accession>
    <name>RL7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplL</name>
        <name type="ordered locus">TDE_2422</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973021.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667605.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JJ6"/>
    <dbReference type="SMR" id="Q73JJ6"/>
    <dbReference type="STRING" id="243275.TDE_2422"/>
    <dbReference type="PRIDE" id="Q73JJ6"/>
    <dbReference type="EnsemblBacteria" id="AAS12940">
        <property type="protein sequence ID" value="AAS12940"/>
        <property type="gene ID" value="TDE_2422"/>
    </dbReference>
    <dbReference type="GeneID" id="2739847"/>
    <dbReference type="KEGG" id="tde:TDE_2422"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2289"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_3_0_12"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="1822695at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000243522" description="50S ribosomal protein L7/L12">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <sequence length="129" mass="13223" checksum="FA211F6DDB17CDC5" modified="2004-07-05" version="1">MAALTNEQIIEAIGEKTILELSELIKAMEEKFGVTAAAPVAVVAGGAAGGGAAEEEKTEFTVTLKGLSDPGKKIGVIKEVRNVIPGLGLKEAKELVEGAPKVLKEDVSKEEAAKIKEAITAAGGEVEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JK4</accession>
    <name>Q73JK4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973013.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680350.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2414"/>
    <dbReference type="EnsemblBacteria" id="AAS12932">
        <property type="protein sequence ID" value="AAS12932"/>
        <property type="gene ID" value="TDE_2414"/>
    </dbReference>
    <dbReference type="GeneID" id="2739839"/>
    <dbReference type="KEGG" id="tde:TDE_2414"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2280"/>
    <dbReference type="eggNOG" id="ENOG5031HP6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117672_0_0_12"/>
    <dbReference type="OrthoDB" id="2013965at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="199" mass="22725" checksum="7F365B5A24EACE45" modified="2004-07-05" version="1">MKKLVLIALIAILFAGCGKKEKGIVTIENKSSYPIEFEFAQNYESKMIILQPNDSIDCVWERYFHCIIKKPSTNILKKQETKEKILILNNDKLYSYTVQNGVCNLTMLDNNQFLLALPTNSPTDSITLNKGQSNIKTFRSLSVQNVIFDKNITIGTDQYLQFKRDGNLFYYKKTSGDYSIAIIKVEISGNNIIIFKINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JM7</accession>
    <name>Q73JM7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972989.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680320.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73JM7"/>
    <dbReference type="STRING" id="243275.TDE_2390"/>
    <dbReference type="EnsemblBacteria" id="AAS12908">
        <property type="protein sequence ID" value="AAS12908"/>
        <property type="gene ID" value="TDE_2390"/>
    </dbReference>
    <dbReference type="GeneID" id="2740692"/>
    <dbReference type="KEGG" id="tde:TDE_2390"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2258"/>
    <dbReference type="eggNOG" id="ENOG5032N79">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808774_0_0_12"/>
    <dbReference type="OrthoDB" id="1258679at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285801" evidence="2">
        <location>
            <begin position="22"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="347" mass="39262" checksum="5EF3C985DEDF3F2B" modified="2004-07-05" version="1">MKVNFVRKFVLLLCVSFFAFASCTKEDVTSKSESENPESMDSMEKDSPKESMAEVNEDGVIYVHRAGLYTETNDGKMKWTAEASLGDVAIYLGEKKEAQRTDGQKREFFHISLKDKEYWIQDYCYEPNTIAGFISAADTVLYKSDSLTAVTDEIIPQYFIVAVYKDSLNSSNQKFVKIAAYCPELVTSWIVKEKYAKRDTVEFQKENVAAMVLAQIAMETQSETSRAELFQNAIEMDSRYSDDIAILQNLAQVLDAEAAFLKKLVTEKIDKKFTAKEDIDLLSIPSSEGEPRVLASVKADTILYASKKVVFVNIVGGNDDSSPQTEWYYVQNKQKKGWVQASYLEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JN4</accession>
    <name>Q73JN4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973047.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667531.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2448"/>
    <dbReference type="EnsemblBacteria" id="AAS12966">
        <property type="protein sequence ID" value="AAS12966"/>
        <property type="gene ID" value="TDE_2448"/>
    </dbReference>
    <dbReference type="GeneID" id="2739633"/>
    <dbReference type="KEGG" id="tde:TDE_2448"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2316"/>
    <dbReference type="eggNOG" id="ENOG5030VVJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1776636_0_0_12"/>
    <dbReference type="OrthoDB" id="1999350at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="146" mass="16720" checksum="5507B8A69E01E8C3" modified="2004-07-05" version="1">MTSFFCTPLFVVLLFFSCKSRRIAEPLEPPKPEVLIEKEPEDPFLGLYVMDLPASRSGITSYSVEFNSDQTARVLVFKEGRTEPEISHGNWLIAKDGIIILYFRQNIPSEFFIKNDDGSLSFLNAQRKPYSGELAELLILRKIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JN7</accession>
    <name>Q73JN7_TREDE</name>
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        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973044.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667543.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12963">
        <property type="protein sequence ID" value="AAS12963"/>
        <property type="gene ID" value="TDE_2445"/>
    </dbReference>
    <dbReference type="GeneID" id="2739630"/>
    <dbReference type="KEGG" id="tde:TDE_2445"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2313"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_8_12"/>
    <dbReference type="OMA" id="DASANHI"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="101" mass="11862" checksum="A7DC2797F33EB72D" modified="2004-07-05" version="1">MTLQEIFISNLRRIRKEKHITQEKLAELCNTDTAYIGQIETHKRFPSINFIEKIASALQIEATELFKNHKKDKLSPSLKLELHNELINEFDKLLSETLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JP4</accession>
    <name>Q73JP4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973037.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675897.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2438"/>
    <dbReference type="EnsemblBacteria" id="AAS12956">
        <property type="protein sequence ID" value="AAS12956"/>
        <property type="gene ID" value="TDE_2438"/>
    </dbReference>
    <dbReference type="GeneID" id="2739863"/>
    <dbReference type="KEGG" id="tde:TDE_2438"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2306"/>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050982_1_2_12"/>
    <dbReference type="OMA" id="VFEGIWW"/>
    <dbReference type="OrthoDB" id="599322at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="3">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="191"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="430" mass="48552" checksum="E6745DE1F3CDF030" modified="2004-07-05" version="1">MKEKKRYKKTDIEFSQPKKTPLIVRFVLWIKHIPASDIFRILAGFAFIFLVLVVIIFVSEANSNSRINNFFDAFWYSLVTITTVGYGDITPSTILGRLAGIILLLFGVVAFAGVSGKVASFFFDRQVKKDRGLIRLEKIKNHFLICGWKPNFDRILLGIISSNPDIPIDHIVLINNASPENMDIIKTDRRFKGLIYLFGDYTDEATLLRANVRYAERALILSDYSQNASPMEIDSRTVLAVLTIGSLNSHIYTAAELIDSKFRQHLSLAHCDEIILSTDYERSILVSASSGTGLSHVLRELITEKSGEGLIINDIPFEFIGKTYREYRRSLSGGRVLIGLLENTGNFYSRRKEALHEAQKNPNIQQIVNNLKKIKRLKSNEPILTPPDEYIIKPNSRGIFVSGRKRTDFTLDGTALDDSQILNEGGSDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JU1</accession>
    <name>Q73JU1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973092.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13011">
        <property type="protein sequence ID" value="AAS13011"/>
        <property type="gene ID" value="TDE_2494"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2494"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2361"/>
    <dbReference type="HOGENOM" id="CLU_3206551_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS13011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="45" mass="5044" checksum="5AA13A1DC9935AFC" modified="2004-07-05" version="1">MSQPLLRDVDGREVPAASARIVRTGGKQQRQNCGRDERRNSCFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
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        <name evidence="10" type="ordered locus">TDE_2510</name>
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    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="75"/>
        </location>
    </feature>
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        <location>
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            <end position="150"/>
        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50929"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="577" mass="63745" checksum="40F275846B1ACC10" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
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            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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            <end position="233"/>
        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="313" mass="35941" checksum="992850BFB5FDEFE0" modified="2004-07-05" version="1">MEKKYAILIDGDNIAPSYLDSIISEVSKEGEVLIKRLYGDWTTPNMNGWKPWLEKVPIRPVQQFRNGPNATDNTIIMDAIELANTNQGINAVCIVSTDSDYYSLALKLREYGLYVLGIGKSNAKPLWVNACNEFKYLENFDETEEYEEDAKSGKKFKSLEDLICHAYRNSRMTEEGWVSLSDLGNSIRNFMPEFDPRSYSHNTLREIIDALSDDFELRSDDRIPPNYWIKAIGRKNETPKIKGKIKRLMNRYGIIENENGDFFFSFTNIDKKCRDKLIKEGTPVKFRVFKMPNPKGEDSADRNGKAAEIEIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JY3</accession>
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            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="AAS13047"/>
        <property type="gene ID" value="TDE_2530"/>
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    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RADICAL_SAM"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS13047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="275" mass="31851" checksum="BC1CDDEAEF6907A7" modified="2004-07-05" version="1">MNIYRGCSHGCIYCDSRSECYQMVHSFEDIEVKENAVELLEEALIKKRKKCMIGMGSMTDPYLPIEKELGLTRKIIETIYRYGFGFTLITKSSLILRDLDLLKAVNKKTKCVVQMTLTTYDDALCKILEPNVAVTSERFKVLKKLNEEGIPTVVWLTPILPFINDTPENIEGLLRYCIEAKVFGIISFGMGLTLRKGNREFFYKKLDQHFPGLKQKYIRLYGESYSVMSPHNASLMNMFFKLCKENGIEHNPDKIFAYLNSFEDKQQSQLEFFCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K05</accession>
    <name>Q73K05_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973158.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680535.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2560"/>
    <dbReference type="EnsemblBacteria" id="AAS13077">
        <property type="protein sequence ID" value="AAS13077"/>
        <property type="gene ID" value="TDE_2560"/>
    </dbReference>
    <dbReference type="GeneID" id="2739925"/>
    <dbReference type="KEGG" id="tde:TDE_2560"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2419"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057504_0_2_12"/>
    <dbReference type="OMA" id="AHEVIMQ"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="282" mass="33292" checksum="625B39FA9F500832" modified="2004-07-05" version="1">MKNDTNFKITLRNDYAFKRIFGTEENTDILQDLLECILDILPENIAGLELLDKEFHKEILTEKLGILDIKLRLKDKTIINIEIQNRWRGDFPERSVYYWSKMYNESIKQGQDYTNLPKCITINLIGKGFNKNKRLHNKYFVMEKDTKEPLFSKLEIHIINLETAKLLEESNYTDIKTKRLLSWLKFIETDDREVRKMLAQNSKTMKKANAAIEVMEMSPRDKWLYESRMKYQHDMASEKHEGYTEGVYQTKLETAKNLLDLGVAHEVIMQATGLKQDEINNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K37</accession>
    <name>Q73K37_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GGDEF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973178.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680563.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2580"/>
    <dbReference type="EnsemblBacteria" id="AAS13097">
        <property type="protein sequence ID" value="AAS13097"/>
        <property type="gene ID" value="TDE_2580"/>
    </dbReference>
    <dbReference type="GeneID" id="2741284"/>
    <dbReference type="KEGG" id="tde:TDE_2580"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2440"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_242103_0_0_12"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="858"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="1470"/>
            <end position="1601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1774" mass="207184" checksum="E4224B0C0EF81A7F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K52</accession>
    <name>Q73K52_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972969.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674194.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2370"/>
    <dbReference type="EnsemblBacteria" id="AAS12888">
        <property type="protein sequence ID" value="AAS12888"/>
        <property type="gene ID" value="TDE_2370"/>
    </dbReference>
    <dbReference type="GeneID" id="44155130"/>
    <dbReference type="KEGG" id="tde:TDE_2370"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2238"/>
    <dbReference type="HOGENOM" id="CLU_209121_0_2_12"/>
    <dbReference type="OrthoDB" id="2059382at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="45" mass="4818" checksum="2126B71B09E05B3C" modified="2004-07-05" version="1">MKKKIAAILVIILALSFTLIGIYRGEVAVVLKKAVNICMECIGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K56</accession>
    <name>Q73K56_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">High-affinity branched-chain amino acid ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972965.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680288.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2366"/>
    <dbReference type="EnsemblBacteria" id="AAS12884">
        <property type="protein sequence ID" value="AAS12884"/>
        <property type="gene ID" value="TDE_2366"/>
    </dbReference>
    <dbReference type="GeneID" id="2739975"/>
    <dbReference type="KEGG" id="tde:TDE_2366"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2234"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_3_0_12"/>
    <dbReference type="OMA" id="MLIWSRN"/>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="299" mass="32186" checksum="D3712AB16BFAFBAE" modified="2004-07-05" version="1">MLLQQLINGLVIGSTYALVTIGFNMVYGVLELTNFAHSSFYMLAAYIGQFILLKFFMTVSVPIALIITFLTSIIITAFLGALMDKIALEPIRIKKGAPISSLISTVGVQTIINNSVLLIFGTVPLYFPDLLKLGKFTIYGGTVVQWIQVLILIMTLIIMLVLTFIVTRTRLGKSMRAISQNQVAARLMGININRVITLTFFIGTTVAGISGLMVAMYYQRVDTLMGASVGLKSFAAAVLGGMGSLPGAAIGGLLIGLLETLFAAYISSGYRDIVAFVILILVLLIRPSGLMGKKSVDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K63</accession>
    <name>Q73K63_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DAK2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972958.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680280.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2359"/>
    <dbReference type="EnsemblBacteria" id="AAS12877">
        <property type="protein sequence ID" value="AAS12877"/>
        <property type="gene ID" value="TDE_2359"/>
    </dbReference>
    <dbReference type="GeneID" id="2739968"/>
    <dbReference type="KEGG" id="tde:TDE_2359"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2227"/>
    <dbReference type="eggNOG" id="COG1461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066424_1_0_12"/>
    <dbReference type="OMA" id="MENRSAF"/>
    <dbReference type="OrthoDB" id="1689902at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="5"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="209" mass="22544" checksum="0EE22FB214CE30D0" modified="2004-07-05" version="1">MITKDIILDVLIEIAKTMDDEKGYLIELDQQNGDGDLGISMSAGFNAAVNAFKDDSGKDIGLGILKAAMAFNEKAPSSLGTILSFGLMAMGKAFKGKQDLTGEDIASGFSKFNEEIMKKGGAKPGEKTLVDTLVPVEKFVRENLGKIPDRELIKESEKIAKEGSDSTRNMKSVHGRAAYYAEKSIGILDGGSYAGYLVFKALNNYLKDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K76</accession>
    <name>ISPT_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoprenyl transferase</fullName>
            <ecNumber evidence="1">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uppS</name>
        <name type="ordered locus">TDE_2344</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972943.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675801.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73K76"/>
    <dbReference type="SMR" id="Q73K76"/>
    <dbReference type="STRING" id="243275.TDE_2344"/>
    <dbReference type="EnsemblBacteria" id="AAS12862">
        <property type="protein sequence ID" value="AAS12862"/>
        <property type="gene ID" value="TDE_2344"/>
    </dbReference>
    <dbReference type="GeneID" id="2739439"/>
    <dbReference type="KEGG" id="tde:TDE_2344"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2212"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_1_1_12"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000123705" description="Isoprenyl transferase">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <sequence length="227" mass="25879" checksum="1702F80788DDBF26" modified="2004-07-05" version="1">MSDELKHIAIVMDGNGRWAKKRGLPRSMGHKEGLNTVKRITKAVSDLGIPYITLYIFSTENWKRTEAEVGFLMGLIKQHLKAELKFYADNNIRIEHIGNLSGLPQDIQDEINSVRDKTSAYTGTAIVLGINYGAHDEILRAIKKLNSDELASINEESFSLKLDTGKIPPVDLLIRTGGEKRLSNFLLWQSAYAELYFTDTLWPDWTVENLYEAIEDYKKRNRRYGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KA1</accession>
    <name>Q73KA1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LysM domain/M23/M37 peptidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972918.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667792.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2318"/>
    <dbReference type="EnsemblBacteria" id="AAS12837">
        <property type="protein sequence ID" value="AAS12837"/>
        <property type="gene ID" value="TDE_2318"/>
    </dbReference>
    <dbReference type="GeneID" id="2739413"/>
    <dbReference type="KEGG" id="tde:TDE_2318"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2187"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_7_0_12"/>
    <dbReference type="OMA" id="LFEINGC"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="69"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="119"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="307" mass="33628" checksum="BFA146E8939FD01B" modified="2004-07-05" version="1">MKKTNYLFAGIIVFLLVLGTAYFALDISTPIGTSQTVLDDGMGGGDTRLPTFRPDKEISEITLPPLDYIVYSVKKGDMVGEIASRYGVSQDAIISLNKLRNTRTLQIGQLLKIPSMDGIVYTPKKGDTPEKLADTYKISLEKLALVNNISDNNVLKAGAAIFLPDAKLDWVTLQEINGDLFKSPIRGGYRVTSRYGWRRDPFTGKRSFHNGIDLATYRGAPIYAALPGTIAATGYSNVYGNYVIIRHHSGYQTLYGHMNSILTSRGKYVTAQSKIGTVGTTGRSTGPHVHFTVYKNGATINPVAVWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KA9</accession>
    <name>Q73KA9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2310"/>
    <dbReference type="EnsemblBacteria" id="AAS12829">
        <property type="protein sequence ID" value="AAS12829"/>
        <property type="gene ID" value="TDE_2310"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2310"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2180"/>
    <dbReference type="HOGENOM" id="CLU_3223407_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="44" mass="4795" checksum="A01D6B06961B5AD5" modified="2004-07-05" version="1">MFIPCDYTRIINFCQKESGGSTAGEASRRTASEASRRTAAKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KD9</accession>
    <name>Q73KD9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972879.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2279"/>
    <dbReference type="EnsemblBacteria" id="AAS12798">
        <property type="protein sequence ID" value="AAS12798"/>
        <property type="gene ID" value="TDE_2279"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2279"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2149"/>
    <dbReference type="eggNOG" id="COG1639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043273_0_0_12"/>
    <dbReference type="OMA" id="NSAQFML"/>
    <dbReference type="OrthoDB" id="375160at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="241"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="496" mass="56800" checksum="8345F61A30679941" modified="2004-07-05" version="1">MCLMEKDKRIIVDSEKIETAIRLGVPIVITSYTLPKETEVYITDVISEFLRQLHCTDITDYIVYYTNELTTNAKKANTKRVYFKERGLNISDAEDYEQGMKDFKEDTISNMDHYLELQKKAGLYIKLSLQLKNDNIVLEVSNNSALTRQEFKRIFDKIVRARQFSSLDEAFTQVLDNTEGAGLGLVIMVLMLKKMGLDEKSYTIDVVDGVTLNRVIIPLRLKLKKEAVPLTKAIVEYINEIPQFPENIMQIQRAINDPESKMQKIAQLISSDIGLATDLLKHVNSVAFGLSKPCMNIVEAVKFVGLRGIQNLLYSMGTIKILETTEKEQKEIWENAYRLAFFSLNVAKLTGKRTIVDDAYICGLLHDLGKIILGSMYPELLVKLAEIQAERNIPPQVMDMIMSGMAQAEIGATLAEKWNFPEPIVVTIRYQDNFENAPEEHRELVESVCFADFMLNFSQGKIDYYQIPEALLKRFKIKSEEQLKKLCERFEFAFSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KE1</accession>
    <name>NPD_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="1">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobB</name>
        <name type="ordered locus">TDE_2277</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class U subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972877.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675715.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KE1"/>
    <dbReference type="SMR" id="Q73KE1"/>
    <dbReference type="STRING" id="243275.TDE_2277"/>
    <dbReference type="EnsemblBacteria" id="AAS12796">
        <property type="protein sequence ID" value="AAS12796"/>
        <property type="gene ID" value="TDE_2277"/>
    </dbReference>
    <dbReference type="GeneID" id="2740027"/>
    <dbReference type="KEGG" id="tde:TDE_2277"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2148"/>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_3_0_12"/>
    <dbReference type="OMA" id="SMQVYPA"/>
    <dbReference type="OrthoDB" id="1264438at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01968">
        <property type="entry name" value="Sirtuin_ClassU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028628">
        <property type="entry name" value="Sirtuin_class_U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000110367" description="NAD-dependent protein deacetylase">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01968"/>
        </source>
    </evidence>
    <sequence length="251" mass="28020" checksum="9CF7C31A67F67D5C" modified="2004-07-05" version="1">MDKEKNDYDKLFSEITKARHLVAFTGAGISTLAGIKDFRGKDGLYKQPNTEKMFDIDVFYRDPSVYYGMAKEFIYGLEEKQPAIVHTVLADLEKRGILKAVITQNIDLLHQKAGSKNVIEVHGSPSVHYCINCSYTETFEETAKTAKTGEVPRCPKCGSPIKPAITFFGEALPQKALMKAETEASKSDFMLVLGTSLLVYPAAALPAYTLRNGGKIAIVNNQPTQFDSYTDLLFEDLEETFEEIDKRLKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KF9</accession>
    <name>Q73KF9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4469 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972859.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680128.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2259"/>
    <dbReference type="EnsemblBacteria" id="AAS12778">
        <property type="protein sequence ID" value="AAS12778"/>
        <property type="gene ID" value="TDE_2259"/>
    </dbReference>
    <dbReference type="GeneID" id="2740009"/>
    <dbReference type="KEGG" id="tde:TDE_2259"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2132"/>
    <dbReference type="eggNOG" id="ENOG503295Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092785_0_0_12"/>
    <dbReference type="OMA" id="WNKERNS"/>
    <dbReference type="OrthoDB" id="1776817at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd12843">
        <property type="entry name" value="Bvu_2165_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027824">
        <property type="entry name" value="DUF4469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14734">
        <property type="entry name" value="DUF4469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4469" evidence="1">
        <location>
            <begin position="130"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="236" mass="25480" checksum="715DFFAB794A5C87" modified="2004-07-05" version="1">MLKYCLRENLLTPDENDYMAQTADVRSFSLDEIIDLMMQKGSTLTKADTKAALQVYGEVVSALIKDGAAVNTPLMNTSLSISGVFIGATDSFDKKRHSVNLNLTAGPVLKEALSKIKCEKTEAADTNPYITEVTDIVTGKVNEVLTAGGIIQLVGSRLKFDAKDTAQGIFFIPETGEAVQATVIAENKPARLMAIIPADLAAGSWYIEVRTKYANATKQLKTLKAGRFGKALTRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KJ7</accession>
    <name>Q73KJ7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972821.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680074.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2221"/>
    <dbReference type="EnsemblBacteria" id="AAS12740">
        <property type="protein sequence ID" value="AAS12740"/>
        <property type="gene ID" value="TDE_2221"/>
    </dbReference>
    <dbReference type="GeneID" id="2739497"/>
    <dbReference type="KEGG" id="tde:TDE_2221"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2098"/>
    <dbReference type="eggNOG" id="ENOG502ZZH4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787408_0_0_12"/>
    <dbReference type="OMA" id="SMETAGH"/>
    <dbReference type="OrthoDB" id="1752429at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="344" mass="39332" checksum="191483F04DC9A813" modified="2004-07-05" version="1">MKKILSFGFLLFFLFTAEGFKLIAEEKSAWEGTESGDYLIYQDLSWKEPTWAGFLYYNDNTIGSFVYTSNGRTVAKVLFSGEILDGEFVITGQNNISGINTDPSYTYAINYLMGMLPKLYAWKSQNLIESLIIKTGSKTVDEEQFGGESEVKFQSYIPLFHVKEILDSNKEKAFELVEMGKIRDEKTFFDFKPLEDAKPLESKFVLNSKAKKETKTVDGVKLSLDSQWKQIADNTFLMGNEAFLNVNTIDLKTRPDTKGKEEDFLIKYFSSSGKASKILAKNTDIKGTKQKFKIINSVYDLETKSIKHDIKLVIKRENSKYTVVSLTVDKSSYQKYKDYFDGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KK0</accession>
    <name>Q73KK0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-ACP thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972818.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2218"/>
    <dbReference type="EnsemblBacteria" id="AAS12737">
        <property type="protein sequence ID" value="AAS12737"/>
        <property type="gene ID" value="TDE_2218"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2218"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2095"/>
    <dbReference type="eggNOG" id="COG3884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045466_2_0_12"/>
    <dbReference type="OMA" id="EIEVETW"/>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:acyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002864">
        <property type="entry name" value="Acyl-ACP_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045023">
        <property type="entry name" value="FATA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31727">
        <property type="entry name" value="PTHR31727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01643">
        <property type="entry name" value="Acyl-ACP_TE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="300" mass="34711" checksum="2F6D697401F7386E" modified="2004-07-05" version="1">MKNCYNQSMIIDNKYTIRHKVLTGNIDGKCRATPMEFAILMQELAAGHYSTTGLSVPHLQKMGLTWVITKQHFEITEYPLWMDDLIVQTWAQPPKGFFCFRDFAFFYAKNGKKTSIDEAFEEKCRIEEGREKSLSIEEGFKELKQPIFRASSCWVILNSETGQPVKPDEKTMGNLAFNEDHMEGKVFAKIPACEKWDTEERFRPTLLDIDMNSHVNNLNYLRWILSYMDADFCKGKLLKTLDTNFVSSAMYGEELICRSSRSENICIHSIIRAKDESEVFKARSEWADEKALSRTLNLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KM4</accession>
    <name>Q73KM4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Deoxycytidylate deaminase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972794.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674498.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2193"/>
    <dbReference type="EnsemblBacteria" id="AAS12713">
        <property type="protein sequence ID" value="AAS12713"/>
        <property type="gene ID" value="TDE_2193"/>
    </dbReference>
    <dbReference type="GeneID" id="2740215"/>
    <dbReference type="KEGG" id="tde:TDE_2193"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2070"/>
    <dbReference type="eggNOG" id="COG2131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_2_0_12"/>
    <dbReference type="OMA" id="TKWYVLH"/>
    <dbReference type="OrthoDB" id="1544522at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="7">
        <location>
            <begin position="12"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="165" mass="18475" checksum="F049FD5A6ADECA5D" modified="2004-07-05" version="1">MVDTKEKYKRPSWDEYFMDVCRAIAKRATCDRGRSGCVIARDHQILVTGYVGAPTGLPHCDDVGHQFKKLQHEDGSVTQHCVRTVHAEQNAICQAAKRGISIDGATLYCKMTPCRTCAMLIINCGIVRVVAEKRYHDSADTIEMFKKAGIILEHISDSLEEYKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KS5</accession>
    <name>Q73KS5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_2142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972743.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679969.1">
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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        </source>
    </evidence>
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            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="306" mass="34616" checksum="31F5B3E0D026B212" modified="2004-07-05" version="1">MGKKNTSLGCFFWLAFILLIALLFFINKDNIARVFEKTNAISIFQKKETQEEKQNEVDLEGIQNEIEKIRAAEKDEENSSEGKAEAEPEKPAEQVQKTVKKNSEPQKTTAEDKPKEEKKTSSQNSTEKKTKTETQTVKKNSESKNKDESKKDVAKLEQKNEKASEKRSSKIYLVKIDSDGKLVRKPVMRQLEKTDSPLTDAINSLLQGPTTEEAKQGFRSFIPPDTKLLSIEVKNGVAEVNISEDFQFNRYGIEAYQAQLEQIVFTACEFSTVSSVQFLIKGKKKEYLGAEGIWIGSPLSVNSFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KZ6</accession>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">TDE_2071</name>
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    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="32"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="90" mass="11028" checksum="0F850CC5A4A13145" modified="2004-07-05" version="1">MLENLELEKFDNVLIFSDSYNDDFDDDDFDDDFDDDFDDFDDDDDFDDDFDDFDDDDDFDDDDDFDDDFDDEDFEYDDDDDDLDYDDFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L19</accession>
    <name>Q73L19_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">TDE_2047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_002668328.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2047"/>
    <dbReference type="EnsemblBacteria" id="AAS12560">
        <property type="protein sequence ID" value="AAS12560"/>
        <property type="gene ID" value="TDE_2047"/>
    </dbReference>
    <dbReference type="GeneID" id="2740641"/>
    <dbReference type="KEGG" id="tde:TDE_2047"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1933"/>
    <dbReference type="eggNOG" id="ENOG5034BRF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2385245_0_0_12"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="97" mass="11212" checksum="C3D1E0E735FF7AF5" modified="2004-07-05" version="1">MFVSVVIDPGGRESASHLAEVLTANGFERVQHACWESVTINDEGLVTLKQDIDRVTDYYDIVRLYQYPIQDVFAVTTLYKKKWRRVLVRPPAKKLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L39</accession>
    <name>Q73L39_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972629.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679805.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2026"/>
    <dbReference type="EnsemblBacteria" id="AAS12540">
        <property type="protein sequence ID" value="AAS12540"/>
        <property type="gene ID" value="TDE_2026"/>
    </dbReference>
    <dbReference type="GeneID" id="2740373"/>
    <dbReference type="KEGG" id="tde:TDE_2026"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1912"/>
    <dbReference type="eggNOG" id="ENOG5032GWA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_826225_0_0_12"/>
    <dbReference type="OrthoDB" id="2160996at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="336" mass="39873" checksum="A3131FFD1A8FD5A3" modified="2004-07-05" version="1">MIYEKFKERKKYIFLITVYLVFNFVIMLIVFLRILPGYSSKLYIPVNDSDISILKIEPVLQMLGKYDKNYTLSINGSEFEFGLNMKKVRKILMATLIVFFIPNFTFFVFLLYTYINKIKDFTRKQKIKIIFIITIYVIMNIILFLWIDSYFNKPKNSISFVPLKKEAVVIDSVPTEITERGWYNSQLAQTISGAEYYIAIKLIRVKEIVLIFLKRFYIYNYIYTILLIIYMGYVINLNKEKKYMNMKITDVFFYIGCVLLCVSPMIVKIGKEDVFLYTIFIETLGIGCMLPKVYLDWRYAYYLGKKSTWFFVKLFVLSLIFIAAVLMFTRTLLSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L45</accession>
    <name>Q73L45_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972623.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957128.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73L45"/>
    <dbReference type="STRING" id="243275.TDE_2020"/>
    <dbReference type="EnsemblBacteria" id="AAS12534">
        <property type="protein sequence ID" value="AAS12534"/>
        <property type="gene ID" value="TDE_2020"/>
    </dbReference>
    <dbReference type="GeneID" id="2740367"/>
    <dbReference type="KEGG" id="tde:TDE_2020"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1906"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004358_0_0_12"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1140" mass="130330" checksum="AAB083C3BC1CA2AA" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L78</accession>
    <name>Q73L78_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972590.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679724.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1987"/>
    <dbReference type="EnsemblBacteria" id="AAS12501">
        <property type="protein sequence ID" value="AAS12501"/>
        <property type="gene ID" value="TDE_1987"/>
    </dbReference>
    <dbReference type="GeneID" id="2740440"/>
    <dbReference type="KEGG" id="tde:TDE_1987"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1876"/>
    <dbReference type="eggNOG" id="ENOG502ZISW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154673_0_0_12"/>
    <dbReference type="OMA" id="MIQTENI"/>
    <dbReference type="OrthoDB" id="2034118at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="136" mass="14629" checksum="174F2BC3DA9FEE35" modified="2004-07-05" version="1">MVSNTSPLQALSQIAMPKISAGGRAFVPVKASQVLYAHFKYVSGFAQAQGQSGMSIDKLRILNSIIDQLVSMKTNEAQKAKLTESAAAQIESEISENQIDGLLDYYHNQIKNTMIQTENIGYGGNPLPAAVLDLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LW6</accession>
    <name>Q73LW6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972350.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669467.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1746"/>
    <dbReference type="EnsemblBacteria" id="AAS12261">
        <property type="protein sequence ID" value="AAS12261"/>
        <property type="gene ID" value="TDE_1746"/>
    </dbReference>
    <dbReference type="GeneID" id="2740591"/>
    <dbReference type="KEGG" id="tde:TDE_1746"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1669"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="HEPDYYI"/>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="92"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="4">
        <location>
            <begin position="300"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="413" mass="45563" checksum="7C538D1A547FBB2B" modified="2004-07-05" version="1">MKIKLMDTGKNILFLLVILIVLITSFVLVLIKMQRDTVQDYLSSDKILKVLLVVEDKGVPISISILAYYPETKRAAMFDVPANIGLIIQSLNRTDAIGAVYTEKGISSFKAEIEKLAGISVPFYLTCNLENFSMLTDMLGGLSVFIPSPVDIENDNTHVLLPSGSVSLDGDKIRDFLVYEDDLDAEGESAARKQKAVLALFRAINDNSPEIFSKERFSVLSGNFKSNVAGSDLKNLLESISKMDSERLVPQRLTGAVRIIEDKRLLTPFREGQQIKEIIRQTIAVLASDDSSALERVYALEILNGTNVQGLAKSTSELYQSFAYDVVSIGNSENPVAETVLIDRIGNPSVAKIVAKVIRCKNIQTTQLPAEGEYGSETNVDFTLILGSDFNGFFVVEKKEDKKDSDENDKDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LY8</accession>
    <name>Q73LY8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972328.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12239">
        <property type="protein sequence ID" value="AAS12239"/>
        <property type="gene ID" value="TDE_1724"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1724"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1648"/>
    <dbReference type="eggNOG" id="ENOG5033BRR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1524463_0_0_12"/>
    <dbReference type="OrthoDB" id="2076586at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="176" mass="20832" checksum="6AC4365194D68487" modified="2004-07-05" version="1">MYKWLKFVKLDAMAEATREILNRIYSPIIHKSHELHRTLIKQYTGSKINRGFFNGHYHKNSEGEYQPDMYPIPVISFIGLCDIEFDFDTISITTKISRNQIQLFDWNIISSVHFEIYGVENYLKDYGSKQNYDKIGDNIASSTEKEFFVSIYFPFITSIEDLAKFLTILQKNNFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LZ0</accession>
    <name>Q73LZ0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclophil_like2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972326.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679440.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1722"/>
    <dbReference type="EnsemblBacteria" id="AAS12237">
        <property type="protein sequence ID" value="AAS12237"/>
        <property type="gene ID" value="TDE_1722"/>
    </dbReference>
    <dbReference type="GeneID" id="2739180"/>
    <dbReference type="KEGG" id="tde:TDE_1722"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1646"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099043_2_1_12"/>
    <dbReference type="OrthoDB" id="1961657at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041183">
        <property type="entry name" value="Cyclophilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18050">
        <property type="entry name" value="Cyclophil_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclophil_like2" evidence="1">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="117" mass="13400" checksum="F73349BAFB10DCBD" modified="2004-07-05" version="1">MIKDMQIDGTVLDVEWENNNTVKELKEELKQGEVTIQLSKYSDFEQVGELGKTYSSSDKRITAEAGDIMLYSGNKIVVFYGANTWEYTRIGKIKNLSKEEIKRLLSNSDVVLKIKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M63</accession>
    <name>Q73M63_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972252.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12163">
        <property type="protein sequence ID" value="AAS12163"/>
        <property type="gene ID" value="TDE_1646"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1646"/>
    <dbReference type="HOGENOM" id="CLU_3241002_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="43" mass="5202" checksum="E1189303B62C9173" modified="2004-07-05" version="1">MTICNYEYNFYTLYKFNTIKFVFYAKIYSMVDGAALILYNHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MA4</accession>
    <name>Q73MA4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972211.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671086.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1605"/>
    <dbReference type="EnsemblBacteria" id="AAS12122">
        <property type="protein sequence ID" value="AAS12122"/>
        <property type="gene ID" value="TDE_1605"/>
    </dbReference>
    <dbReference type="GeneID" id="2740846"/>
    <dbReference type="KEGG" id="tde:TDE_1605"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1534"/>
    <dbReference type="eggNOG" id="ENOG502Z9N0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093450_2_0_12"/>
    <dbReference type="OrthoDB" id="1318356at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011733">
        <property type="entry name" value="CHP02185_IM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09605">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02185">
        <property type="entry name" value="Trep_Strep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="192" mass="20807" checksum="5F36BA10509F24B1" modified="2004-07-05" version="1">MKLKDIVRIAVLTVIGFAIGMAISMLTGTLGAIALYASAGFAAFAVGPVFVITAKKVKHRWTAFLFWLIYGLLYTLMGYWIMIPICLVSAVLAEIIIGDYSSNVKVSIAFSAAMFIVAMHPIIFVKVLGAEGITKFAPSISSEQAQWMIQFYTGKAIAIAVACNIVLESLAGLFGTYINKKFFEKSSKKSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MH1</accession>
    <name>Q73MH1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972143.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1537"/>
    <dbReference type="EnsemblBacteria" id="AAS12054">
        <property type="protein sequence ID" value="AAS12054"/>
        <property type="gene ID" value="TDE_1537"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1537"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1474"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_12"/>
    <dbReference type="OMA" id="MDIAWHR"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="350" mass="39275" checksum="9F489BA87BC3A5B9" modified="2004-07-05" version="1">MIYCEKMMELKNRLEHIEKTLDCFLPEKINSSWISQSFGELAYSLPDSFFLNIINPVRDLVKRGGKRWRPLLCVLSCELAEGDPEKAYPLTPLIEFCHTASLVHDDIEDKSDTRRGAPAAHIKYGLDTALNSASWLYFEALNPLINYEVSESVRAVIYSLYSQNLRRLHLGQSMDIGWHSNSDIIPSVDEYITMISLKTGSLAKLAGELGFIAAGKPINEVLEYGKLMTDMGIGFQILDDVKNITEGNAGKRRGDDIVEGKKSLPLIFYTEENPEGVEKIKLLFKQAAKEGIESPAVEASISAICSSKAVKRAEDYGKKIVEASLIKLQNNYKQNEAKELIFDLFNTILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MN1</accession>
    <name>Q73MN1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the core of the flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Periplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Periplasmic flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972083.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668952.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1477"/>
    <dbReference type="EnsemblBacteria" id="AAS11994">
        <property type="protein sequence ID" value="AAS11994"/>
        <property type="gene ID" value="TDE_1477"/>
    </dbReference>
    <dbReference type="GeneID" id="2741592"/>
    <dbReference type="KEGG" id="tde:TDE_1477"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1416"/>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011142_2_0_12"/>
    <dbReference type="OMA" id="IASQTTY"/>
    <dbReference type="OrthoDB" id="636786at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055040">
        <property type="term" value="C:periplasmic flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3 5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="6">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="7">
        <location>
            <begin position="201"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="286" mass="31311" checksum="7A95F8C4A581F745" modified="2004-07-05" version="1">MIINHNMSAMFAQRTQGVTNVRIGKDIEKLSSGLRINRAGDDASGLAVSEKMRSQIRGLNQASANASNGINFIQVAEAFLQETTDIMQRIRELAVQASNGIYSAEDRMQIQVEVSQLVAEVDRIASSAQFNGMNMLTGRFARETGENVVTGSMWFHIGANMDQRMRVYIGTMSAAALGIRDIGDEKIMTIETADAANRSIGTIDEGLKKINKQRADLGGYQNRMELTVVGIDIAAENLQAAESRIRDADMAKQMVEYTKNQILSNTGIAMLAQANNNSQLVMSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MP2</accession>
    <name>Q73MP2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972072.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1466"/>
    <dbReference type="EnsemblBacteria" id="AAS11983">
        <property type="protein sequence ID" value="AAS11983"/>
        <property type="gene ID" value="TDE_1466"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1466"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1407"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_2_2_12"/>
    <dbReference type="OMA" id="HIPWCVR"/>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="391" mass="45035" checksum="8D121969939FF1CB" modified="2004-07-05" version="1">MMKKAGLYIHIPFCLQKCNYCDFFSVRAGRFKNILSGHLSPFVLRLAEDIKIQADKYSINEWDTVYIGGGTPSLLSPDDLYYLSSQIPAAQKNPHREFTVEINPEDLTKDFLSAAVSGGINRFSVGIQSLNDEVLSACKRRGCRKMSLSALELLRSQKGLILSCDLIAGLNKQSLGILKDDIQTLLHFKPEHFSLYALCSNTKLPPEKDDEIAELWSYGKDILEKNSYNKYEVSNFSYKNLYKSIHNEKYWRLEDYIGVGPGAFGSIFFDRKVLHANAHANALRFSAIKNIEKWMTLKNRDEVYEYETIDEKEFIEEAFMMGLRLTEGIDRSFFKSRFGKDISVFAGKTISKWLDRNEAVLTEKRFYLTEKGFLYLNLFLQELFQEIDSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MT9</accession>
    <name>Q73MT9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972024.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679024.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1418"/>
    <dbReference type="EnsemblBacteria" id="AAS11935">
        <property type="protein sequence ID" value="AAS11935"/>
        <property type="gene ID" value="TDE_1418"/>
    </dbReference>
    <dbReference type="GeneID" id="2739695"/>
    <dbReference type="KEGG" id="tde:TDE_1418"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1360"/>
    <dbReference type="eggNOG" id="ENOG5032S5P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045362_0_0_12"/>
    <dbReference type="OMA" id="SIHINDY"/>
    <dbReference type="OrthoDB" id="1402056at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="460" mass="53827" checksum="640A9A96A50321A3" modified="2004-07-05" version="1">MVIRKNAKELFLQNNRFDLIFKYIYIKNKDKKTPFFKNLYLNHIKAFNNFYEEEPSDGVEKSTPEDFVLSFDALYNSIKEKGFDKSLGIIPIGTNGEISDGAHRLACACLLDTDIFIENDGRKDEYDYKFFLERGLDRKYADYAAIEYVKMQPNAYIVNLHSVISEEFDPDVENILKEYGNIYYKKSIALNYNGYVNLKKMSYGSFWQRESWIGDSSNSYLGAQSHAHESMGNGGNLRAYVFVCEQFDCLNEIKKRVRGLFNIGNYSIHINDYREEALALAQFFFNDNSIQIMNLRPFGFEDSDYDSYLMEFKNRITEEDLDINDFSIVGSSPLNILGIRKSADIDFLYSGTKKFNGEDENISSHDSELRYYPASKYDIIYNSSYYFYYEGFKILSLEALYSLKKKRNEKPKDIVDCKTIRKLLHKSDKLVNSKRSILILFTVLKKYIKKIIKYVLRIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MY9</accession>
    <name>Q73MY9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971973.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671440.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1367"/>
    <dbReference type="EnsemblBacteria" id="AAS11884">
        <property type="protein sequence ID" value="AAS11884"/>
        <property type="gene ID" value="TDE_1367"/>
    </dbReference>
    <dbReference type="GeneID" id="2741128"/>
    <dbReference type="KEGG" id="tde:TDE_1367"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1313"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_16_0_12"/>
    <dbReference type="OMA" id="IAHVALW"/>
    <dbReference type="OrthoDB" id="2035522at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="127" mass="14546" checksum="84BEFD961CC5AF37" modified="2004-07-05" version="1">MRIEHIAMYVNDIENAKNFFIKYFKANSSDGYHNKTTNFRSYFLTFDDGARLELMNHPDMQDPNKEIRRTGLSHVAFSVGSKKRVDELTQILQNDGYKVLSGPRTTGDGYYESCIIGPEGNQIEITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N20</accession>
    <name>Q73N20_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971942.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678890.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1336"/>
    <dbReference type="EnsemblBacteria" id="AAS11853">
        <property type="protein sequence ID" value="AAS11853"/>
        <property type="gene ID" value="TDE_1336"/>
    </dbReference>
    <dbReference type="GeneID" id="2741070"/>
    <dbReference type="KEGG" id="tde:TDE_1336"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1284"/>
    <dbReference type="eggNOG" id="COG2845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587847_0_0_12"/>
    <dbReference type="OrthoDB" id="552355at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01829">
        <property type="entry name" value="SGNH_hydrolase_peri2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007407">
        <property type="entry name" value="DUF459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04311">
        <property type="entry name" value="DUF459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="465" mass="53572" checksum="23C60756BC3DDF5C" modified="2004-07-05" version="1">MKLKDTIKKLNDVLPFKIKLKNKKSIFYSANKALSFFLLCIFFFMLLLGKSLDNFSSKIKNPYAAEVFRTAVKPVSELSQKLKLDNLIPSARTFFLRYAGLEGLSDWDSFYYMDSAELIHRERLLALENLGQAIDKSQDKKSSIDNLEKDLERARDGLPAESKPEDVAAVKKMIDELEAKLENVNTVLDRLKDIEQARIAELEKIRLTQKMLELRKEDIFETAVKEGESNVEQAEAPKKVYTYNTERPLRILMIGDSQMHSIAAGFLRLTGQNSSIRVKEISVHSSGFIRSDYYNWPKKLKNVFEESQNERYDIAVIFLGMNDYQNFYADNGKVLVKETEDWESAYRDKVITHLDVLFANTKKVYWLGMPIVRDKIYNAQLLYIEDLQKKIASEYSSIILNKFSLSSIAPGEGVPYTDTVKTAEGKKIRLMKDDGHHYTVSGGEYIMQPFLELLYKDWDLEPCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N53</accession>
    <name>Q73N53_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971909.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1303"/>
    <dbReference type="EnsemblBacteria" id="AAS11820">
        <property type="protein sequence ID" value="AAS11820"/>
        <property type="gene ID" value="TDE_1303"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1303"/>
    <dbReference type="HOGENOM" id="CLU_2884601_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="63" mass="7813" checksum="756FC549A86581CB" modified="2004-07-05" version="1">MSFFRHKPDYFIQFFRHNYCIFHIHMVIYFLLLVKFILILIFQSLEPLCTPLLPLTFFDNKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N73</accession>
    <name>Q73N73_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971889.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668589.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1282"/>
    <dbReference type="EnsemblBacteria" id="AAS11800">
        <property type="protein sequence ID" value="AAS11800"/>
        <property type="gene ID" value="TDE_1282"/>
    </dbReference>
    <dbReference type="GeneID" id="2740575"/>
    <dbReference type="KEGG" id="tde:TDE_1282"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1232"/>
    <dbReference type="eggNOG" id="ENOG5030Y4G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1414617_0_0_12"/>
    <dbReference type="OrthoDB" id="2191472at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284969" evidence="1">
        <location>
            <begin position="25"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="196" mass="22830" checksum="94D6A8B6701E0BBB" modified="2004-07-05" version="1">MKLLKKKSLCICFVVLFFALQVFAGGYGSNDFIIVDSVSNIAYYSVSEGTKKNYFSDLSIVNIQVNDIKKKQTIYIFPKNNTDIIDFFLFEEKLNNAQNRIDYSSNTSSYYDKSHSMVKNNVDITDRKISENIIIKTKSKNGEIKFWICNKRGANLTNIYKYSEKEFVRYYLDAKLKKIIFIKQVGLENIITEIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N82</accession>
    <name>Q73N82_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligopeptide/dipeptide ABC transporter, peptide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971880.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678775.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1273"/>
    <dbReference type="EnsemblBacteria" id="AAS11791">
        <property type="protein sequence ID" value="AAS11791"/>
        <property type="gene ID" value="TDE_1273"/>
    </dbReference>
    <dbReference type="GeneID" id="2740566"/>
    <dbReference type="KEGG" id="tde:TDE_1273"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1224"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_4_12"/>
    <dbReference type="OMA" id="FYNIDDW"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284970" evidence="1">
        <location>
            <begin position="28"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="81"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="531" mass="60325" checksum="02535E3753E5DAAF" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-29" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NE3</accession>
    <name>HSLU_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent protease ATPase subunit HslU</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Unfoldase HslU</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hslU</name>
        <name type="ordered locus">TDE_1211</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971818.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677705.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NE3"/>
    <dbReference type="SMR" id="Q73NE3"/>
    <dbReference type="STRING" id="243275.TDE_1211"/>
    <dbReference type="EnsemblBacteria" id="AAS11729">
        <property type="protein sequence ID" value="AAS11729"/>
        <property type="gene ID" value="TDE_1211"/>
    </dbReference>
    <dbReference type="GeneID" id="2740105"/>
    <dbReference type="KEGG" id="tde:TDE_1211"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1166"/>
    <dbReference type="eggNOG" id="COG1220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033123_0_0_12"/>
    <dbReference type="OMA" id="KYGMIKT"/>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00249">
        <property type="entry name" value="HslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF3">
        <property type="entry name" value="PTHR48102:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000160557" description="ATP-dependent protease ATPase subunit HslU">
        <location>
            <begin position="1"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="64"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="485" mass="54068" checksum="31EE3FF7A957EA25" modified="2004-07-05" version="1">MNEELKDLTPKQTVAELDKYIIGQNKAKRAVAIALRNRMRRLKLPEEIRDEIAPKNILMIGPTGVGKTEIARRLAKLSGAPFLKVEATKYTEVGYVGRDVESMIRDLMAVGYTMVKSEMQEKLKEQAEKNTEESLLDLLLPGSNKKKTAATSAQPQDVSQASSGTTISLPSVSSTAQAEEHKAQNENDMSGTREKFRVMLRENKLEDKMVEVTISPSMGTPTFEFFAGGSNMEDIESAMSNISSMLMGGAKSKRKNVSVKEAREIIMAEQLDRMVDHDKVTDEAKQRVEQMGIIFIDEIDKVASRSDRGGGPDVSREGVQRDILPIVEGSKVSTKYGVVDTRHILFIAAGAFSVSKPSDLIPEFQGRFPLRVELEALHAEDFKRILLEPKNALTKQYAELLETEGVKIEFLDEAIDRMSFLAADVNSKNENIGARRLHTIMEMLLEDISFNASEMGGETVKIDVAYVDERLKDIVQDQDLSRYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NF8</accession>
    <name>Q73NF8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prolyl endopeptidase</fullName>
            <ecNumber evidence="5">3.4.21.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.26" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971802.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678678.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1195"/>
    <dbReference type="ESTHER" id="trede-q73nf8">
        <property type="family name" value="S9N_PPCE_Peptidase_S9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11713">
        <property type="protein sequence ID" value="AAS11713"/>
        <property type="gene ID" value="TDE_1195"/>
    </dbReference>
    <dbReference type="GeneID" id="2741156"/>
    <dbReference type="KEGG" id="tde:TDE_1195"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1151"/>
    <dbReference type="eggNOG" id="COG1505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_1_1_12"/>
    <dbReference type="OMA" id="ACMTQRP"/>
    <dbReference type="OrthoDB" id="315644at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="468"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="685" mass="77230" checksum="3EB5BBF05F48B937" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NG9</accession>
    <name>Q73NG9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971791.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682432.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1183"/>
    <dbReference type="EnsemblBacteria" id="AAS11702">
        <property type="protein sequence ID" value="AAS11702"/>
        <property type="gene ID" value="TDE_1183"/>
    </dbReference>
    <dbReference type="GeneID" id="2740080"/>
    <dbReference type="KEGG" id="tde:TDE_1183"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1140"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_12"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="220" mass="24624" checksum="CDDB15314EDE3D8F" modified="2004-07-05" version="1">MERNGIGKTTFIKCLAGILTWSSGSSLIMGKPVEKRTNFLGYVPQAKVPSFSYTVLDFVSFGRSSVNGYFASPSKKDYEASLAVMEELDIAFLKNRFCNEISGGELQLAYIAKALVCKPRILILDEPESNLDFYNQGRVLKTLKKLSRQNKTTIIINSHHIQNMLIIADKGLLLSEGHFLFGSIDLLITNENIKTFFNSDVFVLPVLHEGQSFKTFVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NL2</accession>
    <name>Q73NL2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971748.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956887.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1140"/>
    <dbReference type="EnsemblBacteria" id="AAS11629">
        <property type="protein sequence ID" value="AAS11629"/>
        <property type="gene ID" value="TDE_1140"/>
    </dbReference>
    <dbReference type="GeneID" id="2739999"/>
    <dbReference type="KEGG" id="tde:TDE_1140"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1099"/>
    <dbReference type="HOGENOM" id="CLU_745846_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="371" mass="42514" checksum="95BBDC069193CB97" modified="2004-07-05" version="1">MTNEQVIEAVNRLTETYNALRDTFNTDFTEVKRQAAILQPLYKNGQIIWDGREDFQMTDEPLTNLIGVGTGTVAKYGKWYAQYMVKFTGHTVISNCETQTPVNYIVIKLKLPENKDGTFFIKRSNDDNWSHGIITAWMCNSDKSIKTLLGSQVADKHADYGKSVVFNPKNQDAWDSRYYQWTAFNYNKEDIIKNDEGYSYIALSSSVATWYIGGWAVAERNTDFMWTPTRIFDLDSYNPTNKSTYDSLSGGLTKSYFAANKKHTNVRIPYSKTGNLIIGVLCWADHYTPSPIFTGFKTNVEFDFDKIVCGNFAKIKQNLPNYQWGFIHVPENEVIQNTVEINGLKLLQFNIDVPENERAFHFAGMFTETEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NR6</accession>
    <name>Q73NR6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971694.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682397.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1086"/>
    <dbReference type="EnsemblBacteria" id="AAS11575">
        <property type="protein sequence ID" value="AAS11575"/>
        <property type="gene ID" value="TDE_1086"/>
    </dbReference>
    <dbReference type="GeneID" id="2739098"/>
    <dbReference type="KEGG" id="tde:TDE_1086"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1045"/>
    <dbReference type="eggNOG" id="COG1561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076609_1_0_12"/>
    <dbReference type="OMA" id="EIKSVNH"/>
    <dbReference type="OrthoDB" id="1509828at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="204"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="288" mass="33267" checksum="18C5362ACAD9F996" modified="2004-07-05" version="1">MKSMTGYALTEKTEPNSFISLELKSYNSRYLDLNLNFPFWLSALEPIFRAYFSEKIARGKVEVSLHVKDADIDVDILTNTKVAKAYAKAMREVAEAAGINPEIDINRFSEKDGVIIIERNIDISAWENTLLPIFEETFTKYDKTRLDEGDVLKKDILSNLDRIYASLKVIKKYAPQMEEIFCQNIKERFTELLGSEINEQRIMQEVAVMLVKYTINEEIVRLEAHCNSLSHELKKNEPIGKKLDFICQEINREINTIGSKNQMIEMAQSIIEVKDALENIREQSRNVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-05" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NT9</accession>
    <name>SYM_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="1">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metG</name>
        <name type="ordered locus">TDE_1063</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971671.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682373.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NT9"/>
    <dbReference type="SMR" id="Q73NT9"/>
    <dbReference type="STRING" id="243275.TDE_1063"/>
    <dbReference type="PRIDE" id="Q73NT9"/>
    <dbReference type="EnsemblBacteria" id="AAS11552">
        <property type="protein sequence ID" value="AAS11552"/>
        <property type="gene ID" value="TDE_1063"/>
    </dbReference>
    <dbReference type="GeneID" id="2740824"/>
    <dbReference type="KEGG" id="tde:TDE_1063"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1023"/>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_1_1_12"/>
    <dbReference type="OMA" id="VIWPCIL"/>
    <dbReference type="OrthoDB" id="761140at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000139167" description="Methionine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-binding" evidence="1">
        <location>
            <begin position="622"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="334"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="793" mass="89752" checksum="706F21A22EB94CAA" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NY0</accession>
    <name>Q73NY0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971629.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682338.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1021"/>
    <dbReference type="EnsemblBacteria" id="AAS11510">
        <property type="protein sequence ID" value="AAS11510"/>
        <property type="gene ID" value="TDE_1021"/>
    </dbReference>
    <dbReference type="GeneID" id="2741500"/>
    <dbReference type="KEGG" id="tde:TDE_1021"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.982"/>
    <dbReference type="eggNOG" id="ENOG5032WII">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074357_0_0_12"/>
    <dbReference type="OMA" id="WTASAWT"/>
    <dbReference type="OrthoDB" id="1646140at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031823">
        <property type="entry name" value="TatT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038537">
        <property type="entry name" value="TatT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16811">
        <property type="entry name" value="TAtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="324" mass="35835" checksum="9C828D3963CE8B35" modified="2004-07-05" version="1">MKNKIIFTLILIICLIFSSCSIKKMAYNSAANAMAPLPEKKIKPAPDAPNPITALTGEDDVELVGEVFPVILKLYEGMHIADPAHRGLAIMTGELYIMYSNVFVEGPANYLSDDEYDKKDKAFNRAKKFYKRGYNKILSALDTAYPGFTEAINSDNEEKIESMLKNCKSYDTEALHWAGAGILAAFSLDPLDVQCLQTVQGARLMLEKVCSLDPGYSDGATWEILAKFYASAPDSLGGNIEKAEKAYKKALELSQGKSPSIYVTYALSFCVPKQDSKGFDEAIEKALAVNPESDPDNKLVISISQRYAEWLKENKDMFILGDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P22</accession>
    <name>Q73P22_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971587.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682289.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0977"/>
    <dbReference type="EnsemblBacteria" id="AAS11468">
        <property type="protein sequence ID" value="AAS11468"/>
        <property type="gene ID" value="TDE_0977"/>
    </dbReference>
    <dbReference type="GeneID" id="2740549"/>
    <dbReference type="KEGG" id="tde:TDE_0977"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.939"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_1_0_12"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="98"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="381" mass="41166" checksum="3184E66B91DA4587" modified="2004-07-05" version="1">MTKFKTKHKAHALRKTGAAVLITAALLAVGLLFTSCKQASGSNSSDSGGSSGGGTVPTPPSYDFPEITPPANGIVGVDPNYLPTETDDYLKGVFRAGRKVKLSPYKLGKTEVTYELWHSVRTWAESKGYSFANKGLEGWDGTGGGGIWPNYANIGKPPTTNKNHPVTMVDWRDCIVWCNAYTQMIYSSEAECVYRKSDSDPTVLKDATDGTACDAAYADMNKKGFRLPTEAEWEYAARCQGSDNTNAAQYGDVWLTKLDSASGAKANWWYDAKEAGAVAWYKGNAGDKTHPVGGKRENALGLFDMAGNVWEWCFDRYDSIGTGEVTDPTGAASGTKRVIRGGCWNSTSWCGDRNDCTVGFRGDCSPGSGYNSVGFRLAWRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P28</accession>
    <name>SYR_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="1">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argS</name>
        <name type="ordered locus">TDE_0971</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971581.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682282.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73P28"/>
    <dbReference type="SMR" id="Q73P28"/>
    <dbReference type="STRING" id="243275.TDE_0971"/>
    <dbReference type="EnsemblBacteria" id="AAS11462">
        <property type="protein sequence ID" value="AAS11462"/>
        <property type="gene ID" value="TDE_0971"/>
    </dbReference>
    <dbReference type="GeneID" id="2740543"/>
    <dbReference type="KEGG" id="tde:TDE_0971"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.935"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_1_12"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="OrthoDB" id="1146366at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000242116" description="Arginine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <sequence length="590" mass="66634" checksum="7DBABA318100A0D7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P58</accession>
    <name>Q73P58_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NLP/P60 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971551.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682242.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0941"/>
    <dbReference type="EnsemblBacteria" id="AAS11432">
        <property type="protein sequence ID" value="AAS11432"/>
        <property type="gene ID" value="TDE_0941"/>
    </dbReference>
    <dbReference type="GeneID" id="2740974"/>
    <dbReference type="KEGG" id="tde:TDE_0941"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.907"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016043_8_3_12"/>
    <dbReference type="OMA" id="WKRAYWQ"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284615" evidence="2">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="3">
        <location>
            <begin position="26"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="159" mass="17931" checksum="27780ECC2668E8D1" modified="2004-07-05" version="1">MKKIFIFVLLSFFLNGCMTFGAQPPESPRLDFINAAYKYLKTPYKYAGTTKAGMDCSGFVYRAALDALEISIPRSTKGLADFAKRISDKEVQPGDLLFFYTVGNKVSHVGIYIGNREFIHSASQGKHTGVIISSLDEKYWKDTYRFAGRILDPEDIFNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-21" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P70</accession>
    <name>OTCC_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ornithine carbamoyltransferase, catabolic</fullName>
            <shortName evidence="2">OTCase</shortName>
            <ecNumber evidence="2">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arcB</name>
        <name type="ordered locus">TDE_0929</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971539.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682235.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73P70"/>
    <dbReference type="SMR" id="Q73P70"/>
    <dbReference type="STRING" id="243275.TDE_0929"/>
    <dbReference type="PRIDE" id="Q73P70"/>
    <dbReference type="EnsemblBacteria" id="AAS11420">
        <property type="protein sequence ID" value="AAS11420"/>
        <property type="gene ID" value="TDE_0929"/>
    </dbReference>
    <dbReference type="GeneID" id="2740394"/>
    <dbReference type="KEGG" id="tde:TDE_0929"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.897"/>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_1_12"/>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="OrthoDB" id="988597at2"/>
    <dbReference type="UniPathway" id="UPA00254">
        <property type="reaction ID" value="UER00365"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019547">
        <property type="term" value="P:arginine catabolic process to ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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    </dbReference>
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        </location>
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        <location>
            <begin position="65"/>
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        <ligand>
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            <position position="92"/>
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        </ligand>
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            <position position="116"/>
        </location>
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            <begin position="143"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="239"/>
        </location>
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            <name>L-ornithine</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="243"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
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        <location>
            <begin position="280"/>
            <end position="281"/>
        </location>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
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    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <sequence length="338" mass="38189" checksum="F76D4503F3190DB8" modified="2004-07-05" version="1">MLKEIRGKSAKNLRGRSFLKLLDFTTDEIRYLLDLSKNFKDMKRAGIPHRYLEGKNIVLLFEKTSTRTRCSFEVAGYDLGMGVTYLDPNSSQMGHKESIEDTARVLGRMYDGIEYRGFSQELVETLAEYSGVPVWNGLTDLFHPTQMLADLLTIEEKFGYLKGLKFTYMGDARNNVANSLMIACVKMGMHFTACSPKHLFPTEDLVAEAKKIAAQTGGSVTLTENVSEGTKGAHVLYTDIWVSMGEPDSVWEERIKLLKPYQVNKAAMDNADKDAIFLHCLPSFHDLKTTKGQEINKKFGLPEMEVTNEVFESHKSVVFDEAENRMHTIKAVMYATMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PA3</accession>
    <name>Q73PA3_TREDE</name>
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        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0896</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="155"/>
        </location>
    </feature>
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            <end position="182"/>
        </location>
    </feature>
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            <end position="273"/>
        </location>
    </feature>
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            <end position="305"/>
        </location>
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            <end position="308"/>
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            <end position="579"/>
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    </feature>
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        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="595" mass="66213" checksum="671975EB6FA58B2C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PD9</accession>
    <name>Q73PD9_TREDE</name>
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        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rsuA</name>
        <name evidence="5" type="ordered locus">TDE_0860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS11351">
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        <property type="gene ID" value="TDE_0860"/>
    </dbReference>
    <dbReference type="GeneID" id="2741371"/>
    <dbReference type="KEGG" id="tde:TDE_0860"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.829"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="3"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="245" mass="27788" checksum="72F2E1082FE2AEDF" modified="2004-07-05" version="1">MKTRLDRILALSGLGSRSDVKKMIRKKNCCVDGVRIVSPSFILDTDLNKITIDGEPLVLRTNVYLMFNKPQGCVTSTSDPVHKTVMDYIKAPFDRMTLFPIGRLDIDTEGLLIITDDGEITHKITSPKSGTVKTYYLELSREPSDEEFKNYCEEFEKGIVLKNGYKCLPAKFEKCENKTGSFRSGFLMHITEGKFHQVKKMCLSAGNELCYLRRIAVGSIVLDETLKTGEYRELSAEEIDSLRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PE4</accession>
    <name>Q73PE4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971465.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677237.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0855"/>
    <dbReference type="EnsemblBacteria" id="AAS11346">
        <property type="protein sequence ID" value="AAS11346"/>
        <property type="gene ID" value="TDE_0855"/>
    </dbReference>
    <dbReference type="GeneID" id="2741366"/>
    <dbReference type="KEGG" id="tde:TDE_0855"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.824"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092045_0_0_12"/>
    <dbReference type="OMA" id="ICKVSQQ"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="70"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="189" mass="21255" checksum="E69A3A953F774B2D" modified="2004-07-05" version="1">MYSALEVANICGVVNQTAINWIRNGYLKAFNTPGGQYRVYYEDLLLFIKERGMKIPPELQDSLDDAHWNSIIVIDDDAVLNEAISSFLNKNLPNLTVYKSLDGFDAGAQLVKYKPGFVILDIDLPGVNGKEICKKIKTDPFFGQPYIIVITGLDDESLEKQMKDLGADSFFRKPIDFNAILREINEVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PG4</accession>
    <name>Q73PG4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion-translocating oxidoreductase complex subunit E</fullName>
            <ecNumber evidence="7">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rnf electron transport complex subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nqrD</name>
        <name evidence="7" type="synonym">rnfE</name>
        <name evidence="9" type="ordered locus">TDE_0835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971445.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670120.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0835"/>
    <dbReference type="EnsemblBacteria" id="AAS11326">
        <property type="protein sequence ID" value="AAS11326"/>
        <property type="gene ID" value="TDE_0835"/>
    </dbReference>
    <dbReference type="GeneID" id="2739519"/>
    <dbReference type="KEGG" id="tde:TDE_0835"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.804"/>
    <dbReference type="eggNOG" id="COG4660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046659_1_1_12"/>
    <dbReference type="OMA" id="DGFMMGL"/>
    <dbReference type="OrthoDB" id="1782047at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00478">
        <property type="entry name" value="RsxE_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010968">
        <property type="entry name" value="RnfE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01948">
        <property type="entry name" value="rnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="219" mass="23749" checksum="4C7EDF0C06FFA4E6" modified="2004-07-05" version="1">MKNLSIFTNGIIRNNPLLVLMIGLCSSLAVTTNILNGLGMGLAMTFVIVMSELIISIFRKLIPQDIRIPVFIIVIASFTTIVDLLMQAYTPALADAMGLFIKLIVVNCIIMGRVESFASKESPGKSVLDALGMGVGYTIVLVLISAIREILGSGSLAGNVFIPEAYHIRFFANAPGGFFVFGIMISINLFAKKLLERPKKKIQSSPAPQTEPEAKKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PH8</accession>
    <name>Q73PH8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971431.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0821"/>
    <dbReference type="EnsemblBacteria" id="AAS11312">
        <property type="protein sequence ID" value="AAS11312"/>
        <property type="gene ID" value="TDE_0821"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0821"/>
    <dbReference type="HOGENOM" id="CLU_3405972_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3342" checksum="B529382113624AFC" modified="2004-07-05" version="1">MSSRGNYHNAKFGYEKETSSSVIIPITVPK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PL0</accession>
    <name>RS13_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsM</name>
        <name type="ordered locus">TDE_0789</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971399.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670034.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PL0"/>
    <dbReference type="SMR" id="Q73PL0"/>
    <dbReference type="STRING" id="243275.TDE_0789"/>
    <dbReference type="EnsemblBacteria" id="AAS11280">
        <property type="protein sequence ID" value="AAS11280"/>
        <property type="gene ID" value="TDE_0789"/>
    </dbReference>
    <dbReference type="GeneID" id="2740667"/>
    <dbReference type="KEGG" id="tde:TDE_0789"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.762"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_12"/>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="OrthoDB" id="1772647at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000230578" description="30S ribosomal protein S13">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="121" mass="13693" checksum="2E9C28FE827787FD" modified="2004-07-05" version="1">MARIAGVDLPNKHVNVSLTYIYGISTSSANKICEATKVDPMKKMNDLDEAELAAIREVIDREYKVEGRLRTEVALNIKRLQDIGCYRGQRHRKGLPVRGQRTRTNARTRKGKKKTVAGKKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PM5</accession>
    <name>RL16_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplP</name>
        <name type="ordered locus">TDE_0774</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971384.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670003.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PM5"/>
    <dbReference type="SMR" id="Q73PM5"/>
    <dbReference type="STRING" id="243275.TDE_0774"/>
    <dbReference type="EnsemblBacteria" id="AAS11265">
        <property type="protein sequence ID" value="AAS11265"/>
        <property type="gene ID" value="TDE_0774"/>
    </dbReference>
    <dbReference type="GeneID" id="2740314"/>
    <dbReference type="KEGG" id="tde:TDE_0774"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.747"/>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_12"/>
    <dbReference type="OMA" id="KGAVEYW"/>
    <dbReference type="OrthoDB" id="1786618at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000062239" description="50S ribosomal protein L16">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <sequence length="139" mass="15570" checksum="84711875F36B3DCB" modified="2004-07-05" version="1">MAFSPKRVKHRKVQRGRIKGEATRCNNIDFGDYALVSLEPFLLTNRQIEAARVALNRKIKRGGKLWIRVFPDKPYSKKPAEVRMGGGKGAPEYWVAVVKPGTIIFELAGVDKNLAEQAMTLAGSKLPFKTRFAEQIQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PQ0</accession>
    <name>Q73PQ0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron compound ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_0747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971358.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682008.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0747"/>
    <dbReference type="EnsemblBacteria" id="AAS11239">
        <property type="protein sequence ID" value="AAS11239"/>
        <property type="gene ID" value="TDE_0747"/>
    </dbReference>
    <dbReference type="GeneID" id="2740301"/>
    <dbReference type="KEGG" id="tde:TDE_0747"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.722"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_0_12"/>
    <dbReference type="OMA" id="WFAGSFT"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="343" mass="37341" checksum="E979CF92505D317C" modified="2004-07-05" version="1">MNTEKKKRIIIVFIFLSILFIFAVLINIVSGSVSFSLKDILDICIGERTPSTLEYNVLFKIRFPRILAAILFGIALSISGFLLQTFFRNPIAGPYVLGISSGARLFVGFIILTNFTFNIALNSLFLVFLASAIGSLLSMLLVLVFAKRVRDISILIVVGIMIGYIASAGTNFMIAFASDYKIAGLTMWSMGSFSGITWKMIRISSIIIIPSVIGVFCLSKPLQAYLLGENYAKSMGVNIKNFRLVLIFLSSILSACVTGFAGPISFVGIAVPHLTRLTVSTSQPKILIPAVTLMGASFCLLSDYFARTLFAPTELSLSTITSMIGAPIVIWLMVGKNKKYGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PR9</accession>
    <name>Q73PR9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971339.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669971.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0727"/>
    <dbReference type="EnsemblBacteria" id="AAS11220">
        <property type="protein sequence ID" value="AAS11220"/>
        <property type="gene ID" value="TDE_0727"/>
    </dbReference>
    <dbReference type="GeneID" id="2740091"/>
    <dbReference type="KEGG" id="tde:TDE_0727"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.703"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052511_3_1_12"/>
    <dbReference type="OMA" id="QEADDVW"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="159" mass="17817" checksum="0B72F4BD6C20A7E0" modified="2004-07-05" version="1">MKISFNLNKTAVQIDAPANERLLSVLRREFNLLSLKSSCLSGQCGSCTVLMNDKPVPACFIPVFNVEGKNIITLEYFKTTEEYKIIAAGFDQAGVEMCGFCDAGKIFFTYAILNSNIDIDAPDAEDSIRKYYSSTMCRCTSFEDLFSAIEKISKNQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PW9</accession>
    <name>Q73PW9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971289.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681888.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0676"/>
    <dbReference type="EnsemblBacteria" id="AAS11170">
        <property type="protein sequence ID" value="AAS11170"/>
        <property type="gene ID" value="TDE_0676"/>
    </dbReference>
    <dbReference type="GeneID" id="2739669"/>
    <dbReference type="KEGG" id="tde:TDE_0676"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.657"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_4_2_12"/>
    <dbReference type="OMA" id="ACWYFKS"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="139" mass="15295" checksum="73E51CD7ED14DF61" modified="2004-07-05" version="1">MKISVRFTAAVHTLLCIRYFEKDMRVTSDFISASTGVNAVIIRKILLQLQKAGLVETAAGVGGSHLAQTADKITLLDVYNAINEGDEERDIFNFHPKPNPKCPVGRKIHLVLDDKLDDAQNAMKDSLSKTTIADLSKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PX9</accession>
    <name>Q73PX9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FeS assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sufC</name>
        <name evidence="6" type="ordered locus">TDE_0666</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971279.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672329.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0666"/>
    <dbReference type="EnsemblBacteria" id="AAS11160">
        <property type="protein sequence ID" value="AAS11160"/>
        <property type="gene ID" value="TDE_0666"/>
    </dbReference>
    <dbReference type="GeneID" id="2739214"/>
    <dbReference type="KEGG" id="tde:TDE_0666"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.647"/>
    <dbReference type="eggNOG" id="COG0396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_12"/>
    <dbReference type="OMA" id="MAMLEPK"/>
    <dbReference type="OrthoDB" id="1214676at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
        <property type="entry name" value="ABC_FeS_Assembly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="246" mass="27410" checksum="EE54C9DFCAC2BA2C" modified="2004-07-05" version="1">MKLLDIQGLQMSVDEKQILKNLNLSINKGEVHVVMGPNGAGKSTLAAAIVGNPRYNIDKGKIYFEDELINEVPVYERARKGIFLSFQIPEEVPGLKVEEFLRASKEAVTGEKTPAIKFHKLLSDTMKQLKINPAYANRSLNVGFSGGEKKKNEILQLAILNPKLAILDETDSGLDIDATKIVFEGVSKIRTPDMGILIITHHNKVLDYIKPDFVHILVDGTIVKTGRLELVEYIEKNGYENIKESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PZ2</accession>
    <name>Q73PZ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971266.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681846.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0653"/>
    <dbReference type="EnsemblBacteria" id="AAS11147">
        <property type="protein sequence ID" value="AAS11147"/>
        <property type="gene ID" value="TDE_0653"/>
    </dbReference>
    <dbReference type="GeneID" id="2739201"/>
    <dbReference type="KEGG" id="tde:TDE_0653"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.633"/>
    <dbReference type="eggNOG" id="ENOG502ZBXW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095712_1_0_12"/>
    <dbReference type="OMA" id="MYQAFMI"/>
    <dbReference type="OrthoDB" id="1506157at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="223" mass="24046" checksum="556EE17B40030D35" modified="2004-07-05" version="1">MSDELYEKTFTKPIIRYGRFTNLLSLVLCFLPSILVWVVYGVKPSTQDILTGWGLAASVYAIYAVVEPISYFPILGLPGTYMSFLSGNIGNVRLPTSAVTQEAVSVEPGTKKAEIVSTLGIAGSIVTNLIIVTIAAVGGAALMNIFPKKVLEAFAYVSPAIFGAMFGMFAVKNIKYGIFAFILAMALLNLVKIPVYVMIPACVFGTVAFGFLTYKKPKTEEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q02</accession>
    <name>Q73Q02_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971256.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681839.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0642"/>
    <dbReference type="EnsemblBacteria" id="AAS11137">
        <property type="protein sequence ID" value="AAS11137"/>
        <property type="gene ID" value="TDE_0642"/>
    </dbReference>
    <dbReference type="GeneID" id="2740473"/>
    <dbReference type="KEGG" id="tde:TDE_0642"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.621"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100242_0_0_12"/>
    <dbReference type="OMA" id="WTNDEYN"/>
    <dbReference type="OrthoDB" id="1557417at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284629" evidence="1">
        <location>
            <begin position="18"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="234" mass="26905" checksum="6D4966EA7FB4EC86" modified="2004-07-05" version="1">MKKSVFLLIFISLFLMTAFSEKSIEPEVYQKLVESIVRIEAPKIKDGHIIFTSTARRHVGIAFSHEDYKHIHSFRKLPQSELYEGKEPILFYILPIPDELTEIKYRLVIDGLWSSDPVNMNTAFDNIHSMSVSRIEVPYKKEYKTEVSGKSLVKFTYLGEPKKIIRLAGSFNNWDPFMYDLIEVSPGRYELNLNLPSGTWLYAYFSGGSQLPDNTNKNYVYTADGRVASVITVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q09</accession>
    <name>Q73Q09_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAGPA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971249.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681823.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0635"/>
    <dbReference type="EnsemblBacteria" id="AAS11130">
        <property type="protein sequence ID" value="AAS11130"/>
        <property type="gene ID" value="TDE_0635"/>
    </dbReference>
    <dbReference type="GeneID" id="2739360"/>
    <dbReference type="KEGG" id="tde:TDE_0635"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.613"/>
    <dbReference type="eggNOG" id="COG4632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083031_0_0_12"/>
    <dbReference type="OMA" id="PLYSEGM"/>
    <dbReference type="OrthoDB" id="1587976at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="NAGPA" evidence="2">
        <location>
            <begin position="109"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="293" mass="33108" checksum="AF7A1E5C9B6AB98C" modified="2004-07-05" version="1">MYSNSKCNKFLMYFIFIIFLFCSCQTFYPKNSPEFSFIENSGKNFVWEKLTEGIFLSHIKYEDYPLIIHAVKIDLTNPKLKIVVTEPALFNSKGMVKRETTLSFARRHNTVIALNAAFFNVISFSFSLRGEPLGIHIDKKINLSKPFPKYGALCFLDDNSAFIIESQNTEDIKADIEYAVSGNRIILKNGKPIITNISKKENSRTCVGLADGGKTLYLFFAEGENKKKSRGITYDQAHFFMKKLGAQDAIHLDGGGSSSLIIKKENSFFVQVPSISHFGLRKVVTNLGFIIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q57</accession>
    <name>Q73Q57_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971201.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0587"/>
    <dbReference type="EnsemblBacteria" id="AAS11082">
        <property type="protein sequence ID" value="AAS11082"/>
        <property type="gene ID" value="TDE_0587"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0587"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.567"/>
    <dbReference type="eggNOG" id="COG3568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065532_1_0_12"/>
    <dbReference type="OrthoDB" id="1321868at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="222" mass="25508" checksum="AE11747FD0C61749" modified="2004-07-05" version="1">MFCHESCWNRSLLVPAPVLNPLGRVKSGIFTLSKYGIENAERLQLPGTFSWPLKTVNLKRCLLVSEIKTDVPDKNLYIINLHLSAYDAAGVLRKQEMEYLRNLALKFYNEGHWVIAGGDWNSLFPGVEKNRFMPYTTPEEFLEWIEYLPADFIGKEWKWGFDSSTPTVRLLEKPYVKGENYTTIIDGFICSPNVEIIGVKTTDLNFEVSDHHPVIAEFTLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q93</accession>
    <name>Q73Q93_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971164.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681709.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0550"/>
    <dbReference type="EnsemblBacteria" id="AAS11045">
        <property type="protein sequence ID" value="AAS11045"/>
        <property type="gene ID" value="TDE_0550"/>
    </dbReference>
    <dbReference type="GeneID" id="2740538"/>
    <dbReference type="KEGG" id="tde:TDE_0550"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.535"/>
    <dbReference type="eggNOG" id="ENOG503374R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2083834_0_0_12"/>
    <dbReference type="OrthoDB" id="2037956at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="117" mass="13563" checksum="041296792763B034" modified="2004-07-05" version="1">MCKYCDDIDIAFKNDQTDPRKSFMQIYELLLNKIENAQLTIYAGDCKFKDMLTIIDEEIHYTVCFYLQCPACGAFYFLGACIRGAPVYEKLESITEKEIKNKLWGKEGTFFNNPAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q97</accession>
    <name>Q73Q97_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971160.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010698624.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0546"/>
    <dbReference type="EnsemblBacteria" id="AAS11041">
        <property type="protein sequence ID" value="AAS11041"/>
        <property type="gene ID" value="TDE_0546"/>
    </dbReference>
    <dbReference type="GeneID" id="2740534"/>
    <dbReference type="KEGG" id="tde:TDE_0546"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.531"/>
    <dbReference type="HOGENOM" id="CLU_1170242_0_0_12"/>
    <dbReference type="OrthoDB" id="2067741at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284651" evidence="1">
        <location>
            <begin position="20"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="276" mass="32623" checksum="BDBB109485C2D619" modified="2004-07-05" version="1">MKRKIIRLFLFFLLCNAYGINNKTLVNTQLFETDGLLDYYACEIKKNEIVKILKPNIYYGVSNWKYSVKVLYRNKEYLINIENLIPENTQFCLDDNISLLYSDDIKWLPVHCFDSLQEKNRDVIIKKQPKGFQKYQKEKTEFDDEWYESLSNIVPTYFFNSVFNISNLFNRSSFLIKNIKKSEATYIIEAEVYDWFMPDSILNYSKGDSVLLTISIDGDYLNFFCNNQQLGQFVKTNSKTKNEIESLIRNNTCDLSKITWPRHADGSCDYDSSKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QA0</accession>
    <name>Q73QA0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971157.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681693.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0543"/>
    <dbReference type="EnsemblBacteria" id="AAS11038">
        <property type="protein sequence ID" value="AAS11038"/>
        <property type="gene ID" value="TDE_0543"/>
    </dbReference>
    <dbReference type="GeneID" id="2740531"/>
    <dbReference type="KEGG" id="tde:TDE_0543"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.528"/>
    <dbReference type="eggNOG" id="ENOG5032ZYQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1424311_0_0_12"/>
    <dbReference type="OrthoDB" id="1544438at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="215" mass="25229" checksum="CBA88694FB64A559" modified="2004-07-05" version="1">MIINYCSIYGDSDERNLYFDMGDKIKIDYCEACKMVLNRDEAISQAAKIVKIRKKKFFFSTLDGVSIASQRFYDIYHTYNMQGIEFIPFEKSYGYYVCKFLYTMHFDIVRSKSVRIEYQGKVSYGILDNGSCSVCKRSFGHHHPWPYRMTVEDEKKLNSNTFYRSDIEFGERNFQHPLLWATDGIIQAFTKEKCRIFYKNVEGNFGKGDCGKAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QB0</accession>
    <name>Q73QB0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971147.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681674.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0533"/>
    <dbReference type="EnsemblBacteria" id="AAS11028">
        <property type="protein sequence ID" value="AAS11028"/>
        <property type="gene ID" value="TDE_0533"/>
    </dbReference>
    <dbReference type="GeneID" id="2741752"/>
    <dbReference type="KEGG" id="tde:TDE_0533"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.519"/>
    <dbReference type="eggNOG" id="ENOG502ZQM0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1352697_0_0_12"/>
    <dbReference type="OMA" id="TTPYGRG"/>
    <dbReference type="OrthoDB" id="1457938at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="195" mass="23456" checksum="B9B2097B198ADC09" modified="2004-07-05" version="1">MKSNSYIHNLKIEDVPWHRLPTTYGRSTLFPQYFKILEKMQDTDKIENALYEIAINIEHQSTLWYATPFALIFLTRIFMKALTQSSTNKNAHYIVEELLEVFAVIAESFCEGDELEHAAPLPFFEDMLKEKYLWSEVYNEDDDCLRYEDENVFPDNLFYSFYYYSFEVLKIYREEFVKLKDTEFEVRAKILSSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QC6</accession>
    <name>Q73QC6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0517</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971131.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002665895.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0517"/>
    <dbReference type="EnsemblBacteria" id="AAS11012">
        <property type="protein sequence ID" value="AAS11012"/>
        <property type="gene ID" value="TDE_0517"/>
    </dbReference>
    <dbReference type="GeneID" id="2739254"/>
    <dbReference type="KEGG" id="tde:TDE_0517"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.503"/>
    <dbReference type="eggNOG" id="ENOG50302NR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1711401_0_0_12"/>
    <dbReference type="OrthoDB" id="1465356at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="152" mass="17416" checksum="12236C4611CEAB3D" modified="2004-07-05" version="1">MLKIGKNYTFEDDWNGRQSCLMYFKEDGSASWSVDVGFAKGNFRGETIAPSICINPISTDKNSAAELIGESFSVMTIEESDDREDSFYIYEHEPIVSYKLKILEIRNSKAHIQCSGILIVDGYTEPYEQEKFEIDSWIPVIESVKDWEKFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QD9</accession>
    <name>Q73QD9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971118.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676860.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0504"/>
    <dbReference type="EnsemblBacteria" id="AAS10999">
        <property type="protein sequence ID" value="AAS10999"/>
        <property type="gene ID" value="TDE_0504"/>
    </dbReference>
    <dbReference type="GeneID" id="2739601"/>
    <dbReference type="KEGG" id="tde:TDE_0504"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.490"/>
    <dbReference type="eggNOG" id="ENOG502ZWFG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119045_0_0_12"/>
    <dbReference type="OrthoDB" id="1693116at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="211" mass="25146" checksum="D57D74BFB7AFA245" modified="2004-07-05" version="1">MMLRMDEYKDDLSFLNSMKEYKLRGYNRIKRFIIDMIIFLLRDAIPICGAVMAMSAVIGTVSWLVVDNMILLLFLAVIALFILMSVQYLISKIISVQAEKLYGRQELYLINNSLYFTKDVRIRFNRKISCIKFLEIYQVKKTKFYWELDCSCNKNEKYCNAREDIELALEKLRQDKEKLMTVKEILLIKRQYDNQTEKVIEDVFNNHKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QH5</accession>
    <name>Q73QH5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971082.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681563.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0468"/>
    <dbReference type="EnsemblBacteria" id="AAS10963">
        <property type="protein sequence ID" value="AAS10963"/>
        <property type="gene ID" value="TDE_0468"/>
    </dbReference>
    <dbReference type="GeneID" id="2739222"/>
    <dbReference type="KEGG" id="tde:TDE_0468"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.453"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074356_0_0_12"/>
    <dbReference type="OMA" id="HFFYEDV"/>
    <dbReference type="OrthoDB" id="963283at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033399">
        <property type="entry name" value="Put_LolA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17131">
        <property type="entry name" value="LolA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285010" evidence="1">
        <location>
            <begin position="21"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="257" mass="29163" checksum="2C23D15DE421A959" modified="2004-07-05" version="1">MKKFTLSLIFAIGFCSLIFAQSAEEIVAKTKTKNTASSLGSESSLDMQSGGKTLSTLEIRQYSSLDKNGLQRMFVEIKNPPSYKGSRFLMIEKADGSTDQKMYLAQTKKVQKISAQGSADEPFMGSDFSNNDISFMERDTKLDNFKILGEEEYDGKPVYLIESTPKDKNYTYSKTIMRITKDKNLLLKAEFYQGSQLVKILELYDYKEVNGIMTAHKTKLSTVKTNTSTIITIKRIEYGMKIPDYIFTQKYLETGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QP4</accession>
    <name>Q73QP4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc carboxypeptidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971013.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0399"/>
    <dbReference type="EnsemblBacteria" id="AAS10894">
        <property type="protein sequence ID" value="AAS10894"/>
        <property type="gene ID" value="TDE_0399"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0399"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.388"/>
    <dbReference type="eggNOG" id="COG2866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047694_1_0_12"/>
    <dbReference type="OMA" id="FEICENY"/>
    <dbReference type="OrthoDB" id="558452at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M14" evidence="2">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="445" mass="51194" checksum="90F2B84BAEF8145C" modified="2004-07-05" version="1">MTVDEMNSASKALAKKYPDIVEEFEFGTTRDGDKIIGLKIGKGRQNALVFGLPHPNEPIGTMMLDYFTKELAENNKLRDELNYTWYIVKAWDSDGTRLNEGWFKGPFTLYNYARNFFRPAGHQQVDWTFPIEYKELKFTDSIPETVAMMHLIDKIKPRFIYSLHNAGFGGVYWYLSRDIPKVYAGLKEAAKKQNVPLNLGEPEAPYCKAFAPAIYKELGIRDNYDYLEKYGVKDIPKAIGVGTCSADYAGEKYKSFTMLTELPYFYSEKIIDLSDSGENRGEIVRKSLEENRKSEAFILDSLKKTRKHMAKNNPFLLALDAFTGRKDDYEAAVKMTYEDENYSKKNATVAEKFDNEWIKKFYKMLSFGLLTRANETELFKMKKAKEENKEKEKALSNEFNAAEKKLQVLSDELEANIKYSVVPIKKLVSIQLECGLLVAEYLKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QP7</accession>
    <name>Q73QP7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971010.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681420.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0396"/>
    <dbReference type="EnsemblBacteria" id="AAS10891">
        <property type="protein sequence ID" value="AAS10891"/>
        <property type="gene ID" value="TDE_0396"/>
    </dbReference>
    <dbReference type="GeneID" id="2739405"/>
    <dbReference type="KEGG" id="tde:TDE_0396"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.385"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_12"/>
    <dbReference type="OMA" id="HVMRLFP"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="322" mass="36356" checksum="18404EAAAB3872E8" modified="2004-07-05" version="1">METVLNVEKINITYRNKHKSVYAVKDISFMLNQGDSLGIVGESGSGKSTLAMGLLKLLPARSTAITGCVEFDKKNLLELTDRQYNELRWKEISVVFQKSMNALSPVHRISVQIEDIYRVHYPDTPSQKIKERALYLFSLVNLSSRVYNLYPHELSGGMLQRISIAISLLFSPKLLILDEATTALDTVTQGQILDEIVKLETEMNMTRIMITHDISVVSQSCNKVGIMYAGELMEIGATETVLKYPKHPYTKALIESFPSLYGEKKPLKSIEGFIPDLSQQYKGCIFAPRCKNAMDICKSHKPQKTEFKDGDVYCHLYEEAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QV8</accession>
    <name>Q73QV8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonucleoside-diphosphate reductase subunit beta</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nrdB</name>
        <name evidence="6" type="ordered locus">TDE_0335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
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                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
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                <person name="Weinstock G.M."/>
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        </reaction>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
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    <sequence length="351" mass="40973" checksum="5DC6E0A89F694CF7" modified="2004-07-05" version="1">MITEKTILPHKALFNENGDIETHKRKMIGGNTTNLNDFNNMKYSWASDWYRQAMNNFWIPEEINMTTDVQDYRKLSIPEKTAYDKILSFLIFLDSIQTANLPNVGQYVTANEVNLCLTIQAFQEAVHSQSYSYMLDTICSPEERTEILYQWKDDEHLLRRNKFIGDLYNEFQSDKSALAFLKVCVANYILEGIYFYSGFMFFYNLGRNNKMPGSVQEIRYINRDENTHLWLFRSMIQELQKEEPQLFTPQNVELFRAMIKEGCEQEIAWGDYVIGNDIPGLNSQMITDYIQYLGNLRCENLGFAPIYDGHREEPQSMSWASQYSNANLIKTDFFEAKSTAYAKSSAMVDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
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    </protein>
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    </gene>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
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                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
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                <person name="Sodergren E."/>
                <person name="Baca E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
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            <end position="25"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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    <sequence length="574" mass="63308" checksum="82A62C4DDA578EA1" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QY3</accession>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970924.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681261.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0310"/>
    <dbReference type="EnsemblBacteria" id="AAS10805">
        <property type="protein sequence ID" value="AAS10805"/>
        <property type="gene ID" value="TDE_0310"/>
    </dbReference>
    <dbReference type="GeneID" id="2741031"/>
    <dbReference type="KEGG" id="tde:TDE_0310"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.299"/>
    <dbReference type="eggNOG" id="ENOG502ZXR4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_745847_0_0_12"/>
    <dbReference type="OrthoDB" id="2106708at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="370" mass="43100" checksum="8D1DDDA68751295D" modified="2004-07-05" version="1">MKQKQVIIILYIIVLVMIILPVGILIHWLFFKSGIKFNFNTQNQQEVTNEYIYDFDKSEYIFASTQNEWFELSKNGKWYDVRFNGGDVDTDVIQQFIEAGKCNEGGKEMTLSAGSITITDDGLVVISGDRCICYLDVVNKKIIKILPLEHRDTVAVNIGDRDILFFDGGNLYKYEFDSDNKILLYETKLYKFEISGKDLYKDYPYDYGKEDGGNYIFISNSTAEYPYPYARPVHIAYSKKYNSIYYKTRISLSDGLKTAVVSMSLDDFTIYVVCLDGEFNTDLGGNVFYTQKNALFRHDGDTRKSEKIFEHDETISWFKLFNDAIFFMQKSSPNIKGVKFPEFRVYHQNKVKYVKINANIYRNCWDIIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QY7</accession>
    <name>Q73QY7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal peptide peptidase SppA</fullName>
            <ecNumber evidence="6">3.4.-.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sppA</name>
        <name evidence="6" type="ordered locus">TDE_0306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970920.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681253.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0306"/>
    <dbReference type="EnsemblBacteria" id="AAS10801">
        <property type="protein sequence ID" value="AAS10801"/>
        <property type="gene ID" value="TDE_0306"/>
    </dbReference>
    <dbReference type="GeneID" id="2741027"/>
    <dbReference type="KEGG" id="tde:TDE_0306"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.294"/>
    <dbReference type="eggNOG" id="COG0616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008856_1_1_12"/>
    <dbReference type="OMA" id="DPKGQYL"/>
    <dbReference type="OrthoDB" id="1318587at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004634">
        <property type="entry name" value="Pept_S49_pIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001217">
        <property type="entry name" value="Protease_4_SppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00705">
        <property type="entry name" value="SppA_67K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="5">
        <location>
            <begin position="138"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="5">
        <location>
            <begin position="391"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="609" mass="66554" checksum="64AE3AD5089BF0EE" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R82</accession>
    <name>Q73R82_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arsenical pump membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_0209</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970825.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681109.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0209"/>
    <dbReference type="EnsemblBacteria" id="AAS10706">
        <property type="protein sequence ID" value="AAS10706"/>
        <property type="gene ID" value="TDE_0209"/>
    </dbReference>
    <dbReference type="GeneID" id="2739366"/>
    <dbReference type="KEGG" id="tde:TDE_0209"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.203"/>
    <dbReference type="eggNOG" id="COG1055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011920_4_0_12"/>
    <dbReference type="OMA" id="IAMFIDV"/>
    <dbReference type="OrthoDB" id="626718at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="17"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS10706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="428" mass="46559" checksum="A6442EBB02526410" modified="2004-07-05" version="1">MVTDPLILAAVLFGLTYVLMITLTNHRPIVACSSALIFVLLGILPYNEVFFAIDWNVILMIAGTMGLVALFTESKMPQRIADKIINNVPDVKWIIVCLSLFAGFISAFMDNVATVLMLAPIAVVLSKKLNMSPVKPIIAISISANLQGAATLVGDTTSILLGSHLNMTFFDFFWYLGKPSLFFAVEIAAVAATGIIYFIFRKAVQKPDKVELTKVTDYFPSILLIVMVVLMIGASFLPEEKKPQTINGLICTGLMIVGIIYNIIKTKKLDILKVVKKELSFETLFLLMGLFTVIAAVTRAGVIQAIADWFLTLGSNVFLIYTIIVWGSVLISAFVDNIPYVAAMIPIIQILSEGLNIASPILFFGLLSGATLGGNITPIGASANITSLGILRNEGHQVKNSEFMKMSVPYTLTAVVIGYILIWLCYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R83</accession>
    <name>Q73R83_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycerate kinase</fullName>
            <ecNumber evidence="5">2.7.1.31</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glxK</name>
        <name evidence="5" type="ordered locus">TDE_0208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycerate kinase type-1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.31" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970824.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681108.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0208"/>
    <dbReference type="EnsemblBacteria" id="AAS10705">
        <property type="protein sequence ID" value="AAS10705"/>
        <property type="gene ID" value="TDE_0208"/>
    </dbReference>
    <dbReference type="GeneID" id="2739814"/>
    <dbReference type="KEGG" id="tde:TDE_0208"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.202"/>
    <dbReference type="eggNOG" id="COG1929">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028255_0_0_12"/>
    <dbReference type="OMA" id="CRFEVAC"/>
    <dbReference type="OrthoDB" id="1292731at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018193">
        <property type="entry name" value="Glyc_kinase_flavodox-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004381">
        <property type="entry name" value="Glycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018197">
        <property type="entry name" value="Glycerate_kinase_RE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036129">
        <property type="entry name" value="Glycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21599">
        <property type="entry name" value="PTHR21599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02595">
        <property type="entry name" value="Gly_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006078">
        <property type="entry name" value="GlxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110738">
        <property type="entry name" value="SSF110738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00045">
        <property type="entry name" value="TIGR00045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="388" mass="40696" checksum="C4668C041DCA5252" modified="2004-07-05" version="1">MKKILLIPDSFKGTMSSARICTLMKNAIKEIFPEAQTLSIPVADGGEGSVEAFLEAIGGIKKTVKVKNPFFEEMEGFYGILKNEEPNAEKTAVIEMAACAGLPLALGRLNPSLTTTYGVGELIADALKNGCTNIIIGLGGSATNDGGCGAAAALGVKFFDKEGKSFIPAGGTLKNIERIDMTGLSPLVKKARFTTMCDIDNPLFGKTGAAYIFAPQKGADPGMVEELDQGLKRLALVAGKTESLNSGSETAEIPGAGAAGGMGYGTLVFLGSELKMGIEIVLDTVDFEKKLDNTDFVFTGEGKLDSQSLRGKVVAGVAQRAKKKNVPVIAVVGDAEEGIDDIYKMGVSAVFSINRLAVPFSQAKKTAETDLTATMKDVLRLIGIFSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RA9</accession>
    <name>Q73RA9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970798.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681065.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0182"/>
    <dbReference type="EnsemblBacteria" id="AAS10679">
        <property type="protein sequence ID" value="AAS10679"/>
        <property type="gene ID" value="TDE_0182"/>
    </dbReference>
    <dbReference type="GeneID" id="2741607"/>
    <dbReference type="KEGG" id="tde:TDE_0182"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.178"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_12"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="549" mass="62474" checksum="B0FABE89A77485F2" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RC8</accession>
    <name>Q73RC8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FlgD_ig domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970778.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681041.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0162"/>
    <dbReference type="EnsemblBacteria" id="AAS10659">
        <property type="protein sequence ID" value="AAS10659"/>
        <property type="gene ID" value="TDE_0162"/>
    </dbReference>
    <dbReference type="GeneID" id="2739595"/>
    <dbReference type="KEGG" id="tde:TDE_0162"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.159"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_244145_0_0_12"/>
    <dbReference type="OrthoDB" id="933366at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025965">
        <property type="entry name" value="FlgD_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13860">
        <property type="entry name" value="FlgD_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284666" description="FlgD_ig domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="domain" description="FlgD_ig" evidence="2">
        <location>
            <begin position="1566"/>
            <end position="1619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1634" mass="174129" checksum="F3B7CEC863B1C3D7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RF2</accession>
    <name>Q73RF2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate kinase, FGGY family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970754.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681001.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0137"/>
    <dbReference type="EnsemblBacteria" id="AAS10635">
        <property type="protein sequence ID" value="AAS10635"/>
        <property type="gene ID" value="TDE_0137"/>
    </dbReference>
    <dbReference type="GeneID" id="2741332"/>
    <dbReference type="KEGG" id="tde:TDE_0137"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.137"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_4_12"/>
    <dbReference type="OMA" id="AAYQKKW"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="261"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="519" mass="57862" checksum="01FB46A14793E140" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RI6</accession>
    <name>Q73RI6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970719.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680951.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0102"/>
    <dbReference type="EnsemblBacteria" id="AAS10600">
        <property type="protein sequence ID" value="AAS10600"/>
        <property type="gene ID" value="TDE_0102"/>
    </dbReference>
    <dbReference type="GeneID" id="2741717"/>
    <dbReference type="KEGG" id="tde:TDE_0102"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.102"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640823_0_0_12"/>
    <dbReference type="OMA" id="IFMGEMS"/>
    <dbReference type="OrthoDB" id="1226419at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="307"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="430" mass="49615" checksum="00B5A5124EC3BCAC" modified="2004-07-05" version="1">MKKVPIISTIQTTVDGLKNAAQNIENVDIAVLDKYEDIVSFFKYEMPEIKIIDFGDPNIDAEACVRIIKDDPWLLFGGIIAITNDRQEKAKLEQIKEPNFLFVCTRKDFEKNTEQIIKILNQHQHFLFNRGMHQRADEKETGHFVSDTDPFEIVFYANLIGTYLYNTNRVNEEERSSLQTAMMEFLLNAVEHGNCNISYEEKNKWLRSGKNMLDLIAEKQKQPEIKKKKVYITYSVLPEKTKITIKDEGNGFDWRSHLEADFEAGLHGMGIKLSQTLVKNLRYNNIGNEVSFEVNNQRNIANLTPAILKSQQLLTFKHMQIVCRENEDSSDLFYISSGRYAVYVNNKLMSVLTPADIFIGEMAFLMNDRRSATVVSIGEGSLVKIPKMNFMKLIEEYPHYGIFLSRLLANRLARQSKITAQLKEEQENNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RK4</accession>
    <name>Q73RK4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5 13">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ptsI</name>
        <name evidence="21" type="ordered locus">TDE_0084</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5 13"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970701.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680940.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="STRING" id="243275.TDE_0084"/>
    <dbReference type="EnsemblBacteria" id="AAS10582">
        <property type="protein sequence ID" value="AAS10582"/>
        <property type="gene ID" value="TDE_0084"/>
    </dbReference>
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    <dbReference type="KEGG" id="tde:TDE_0084"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.85"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007308_7_0_12"/>
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    <dbReference type="OrthoDB" id="467393at2"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
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    </dbReference>
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        <property type="entry name" value="PEP_util_C"/>
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        <property type="entry name" value="PEP_util_CS"/>
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        <property type="entry name" value="PTS_EI"/>
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        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="21" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="20">
        <location>
            <begin position="6"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="18">
        <location>
            <begin position="160"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="19">
        <location>
            <begin position="266"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="15">
        <location>
            <begin position="468"/>
            <end position="469"/>
        </location>
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    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        </source>
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        <source>
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        <source>
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            <dbReference type="Pfam" id="PF00391"/>
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        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS10582.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="594" mass="66221" checksum="21A42767B258C8F1" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RL3</accession>
    <name>Q73RL3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sorbitol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="TDE_0075"/>
    </dbReference>
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    <dbReference type="KEGG" id="tde:TDE_0075"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ADH-like_C"/>
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        <property type="entry name" value="ADH_Zn_CS"/>
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        <property type="entry name" value="GroES-like_sf"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="ADH_ZINC"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="12"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="348" mass="37699" checksum="360524C97EA32F62" modified="2004-07-05" version="1">MSIKIRTAAVTGPHKVEILELNTPDLRSGEVLVKVHAVALCTLEQRIFRGEIPMPLPCTGGHEVSGEVVALGDGVNTKKWSAGDRVAVRLLYNCGECHYCHSGHNNLCERAQKKPVRENLLVGPGGLCDYIIVNTSALFPISDELSYEEACLTEPLACCVHSIERANLQLGEDVVVIGGGIMGQYHIMLAKCRGCRVILSEVDPERCKLGKQLGADIVFNPLEHDPVTFIQSLTNGRGADAVFNTTPIPGVVPQAIAMTGKCGRMIQYSSMHPDSPTPVSPQMLHGSEIVLTGAISPDERNFYTANRLLSTGIINCKPLIAKKFPFEEAQKAFEAAIVPGTFRMIITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RQ3</accession>
    <name>Q73RQ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histidine kinase-related ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0032</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970649.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680890.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0032"/>
    <dbReference type="EnsemblBacteria" id="AAS10530">
        <property type="protein sequence ID" value="AAS10530"/>
        <property type="gene ID" value="TDE_0032"/>
    </dbReference>
    <dbReference type="GeneID" id="2741647"/>
    <dbReference type="KEGG" id="tde:TDE_0032"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.34"/>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020211_9_2_12"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032834">
        <property type="entry name" value="NatK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016120">
        <property type="entry name" value="Sig_transdc_His_kin_SpoOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039506">
        <property type="entry name" value="SPOB_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14501">
        <property type="entry name" value="HATPase_c_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14689">
        <property type="entry name" value="SPOB_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55890">
        <property type="entry name" value="SSF55890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SPOB_a" evidence="5">
        <location>
            <begin position="40"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c_5" evidence="4">
        <location>
            <begin position="134"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="248" mass="28612" checksum="D27FB390008CA34E" modified="2004-07-05" version="1">MFIFILVLSSILLLFILLYFLIRRAVNKRFDDFENGLINKYYEDVDSIYKKMRGWRHDFHNHIQVMKAYLEFKNYDELESYLNNLTEDLIKVDSVIKTGNLMSDAILNTKAAIALSHDIKLNIKASIPENIALSDLELCVIIGNLFDNAIEGALSLKEKEKRFIRVYIRKLNDNLYISFTNSCEGRRKKTQGKFLTTKEGKDHGFGSGRIDAIVKKYSAFINRQSEEGAFAVEIMFPLVLLPNLPNVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-24" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>P61474</accession>
    <name>YIDD_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_2398</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972997.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667653.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61474"/>
    <dbReference type="STRING" id="243275.TDE_2398"/>
    <dbReference type="EnsemblBacteria" id="AAS12916">
        <property type="protein sequence ID" value="AAS12916"/>
        <property type="gene ID" value="TDE_2398"/>
    </dbReference>
    <dbReference type="GeneID" id="2740700"/>
    <dbReference type="KEGG" id="tde:TDE_2398"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2264"/>
    <dbReference type="eggNOG" id="COG0759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144811_6_0_12"/>
    <dbReference type="OMA" id="QPTCSHY"/>
    <dbReference type="OrthoDB" id="1912220at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000171892" description="Putative membrane protein insertion efficiency factor">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <sequence length="73" mass="8202" checksum="4BBB0A0E4B980322" modified="2004-05-24" version="1">MRKLLVSFLCACIIFYQKAISPHFPPSCRYEPTCSQYAIESIKKYGPFKGAGMALLRILRCNPLCKGGYDPVP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-05" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>P62443</accession>
    <name>RL11_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplK</name>
        <name type="ordered locus">TDE_2425</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973024.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667599.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P62443"/>
    <dbReference type="SMR" id="P62443"/>
    <dbReference type="STRING" id="243275.TDE_2425"/>
    <dbReference type="EnsemblBacteria" id="AAS12943">
        <property type="protein sequence ID" value="AAS12943"/>
        <property type="gene ID" value="TDE_2425"/>
    </dbReference>
    <dbReference type="GeneID" id="2739850"/>
    <dbReference type="KEGG" id="tde:TDE_2425"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2292"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_2_1_12"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1702697at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000104402" description="50S ribosomal protein L11">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <sequence length="143" mass="15065" checksum="0889C8821EF2ECF9" modified="2004-07-05" version="1">MAKKKVVTQIKLQCPAGKATPAPPIGPALGPHGVSAPQFVQQFNDRTKSMEPGLVIPVVITVYADKSFTFILKTPPASVLIKKACKIEKGSATSVTAKVGKLSKAALEEIAKTKMPDINANDIEAAKKIIAGTARSMGVEVER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1993-10-01" modified="2022-08-03" version="142" xmlns="http://uniprot.org/uniprot">
    <accession>Q04595</accession>
    <name>PYRB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>Protein PyrBI</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName>Aspartate carbamoyltransferase</fullName>
                <ecNumber>2.1.3.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName>Aspartate transcarbamylase</fullName>
                <shortName>ATCase</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>Aspartate carbamoyltransferase regulatory region</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name type="primary">pyrBI</name>
        <name type="synonym">pyrB</name>
        <name type="ordered locus">TDE_0129</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1992" name="Appl. Environ. Microbiol." volume="58" first="3399" last="3403">
            <title>Cloning and expression of the aspartate carbamoyltransferase gene from Treponema denticola.</title>
            <authorList>
                <person name="Ishihara K."/>
                <person name="Ishihara M."/>
                <person name="Takazoe I."/>
                <person name="Okuda K."/>
            </authorList>
            <dbReference type="PubMed" id="1444372"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 33520 / W / CIP 103917</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the PyrI family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="BAA00941" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.1.3.2"/>
    <dbReference type="EMBL" id="D10052">
        <property type="protein sequence ID" value="BAA00941.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="A48948">
        <property type="entry name" value="A48948"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970746.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666669.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q04595"/>
    <dbReference type="SMR" id="Q04595"/>
    <dbReference type="STRING" id="243275.TDE_0129"/>
    <dbReference type="EnsemblBacteria" id="AAS10627">
        <property type="protein sequence ID" value="AAS10627"/>
        <property type="gene ID" value="TDE_0129"/>
    </dbReference>
    <dbReference type="GeneID" id="2739612"/>
    <dbReference type="KEGG" id="tde:TDE_0129"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.129"/>
    <dbReference type="eggNOG" id="COG0540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039403_0_0_12"/>
    <dbReference type="OMA" id="QAINGYW"/>
    <dbReference type="OrthoDB" id="477078at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020545">
        <property type="entry name" value="Asp_carbamoyltransf_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020542">
        <property type="entry name" value="Asp_carbamoyltrfase_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036792">
        <property type="entry name" value="Asp_carbatrfase_reg_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036793">
        <property type="entry name" value="Asp_carbatrfase_reg_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01948">
        <property type="entry name" value="PyrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02748">
        <property type="entry name" value="PyrI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54893">
        <property type="entry name" value="SSF54893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57825">
        <property type="entry name" value="SSF57825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000113241" description="Protein PyrBI">
        <location>
            <begin position="1"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate carbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate carbamoyltransferase regulatory region">
        <location>
            <begin position="371"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA00941." evidence="2" ref="1">
        <original>K</original>
        <variation>E</variation>
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="535" mass="61944" checksum="15BDF8A8F5D57A81" modified="2004-04-13" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q3V8B7</accession>
    <name>Q3V8B7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Flagellar biosynthetic protein FliQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">fliQ</name>
        <name evidence="10" type="ordered locus">TDE_0052</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970669.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666830.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q3V8B7"/>
    <dbReference type="STRING" id="243275.TDE_0052"/>
    <dbReference type="EnsemblBacteria" id="AAS10550">
        <property type="protein sequence ID" value="AAS10550"/>
        <property type="gene ID" value="TDE_0052"/>
    </dbReference>
    <dbReference type="GeneID" id="2741667"/>
    <dbReference type="KEGG" id="tde:TDE_0052"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.54"/>
    <dbReference type="eggNOG" id="COG1987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164516_2_1_12"/>
    <dbReference type="OMA" id="TMPWMLN"/>
    <dbReference type="OrthoDB" id="1939288at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006305">
        <property type="entry name" value="FliQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004669">
        <property type="entry name" value="FliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01402">
        <property type="entry name" value="fliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="89" mass="9729" checksum="98C7D0E97EB9C9D5" modified="2011-07-27" version="1">MTTGTIVTLMREGIGIILMLSAPILVAALLVGLIVAIFQATTSIQEQTLTFVPKILTILGMIALLATWMITVLREYFVSLMNLIPQLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J22</accession>
    <name>Q73J22_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase</fullName>
            <ecNumber evidence="1">4.3.1.12</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">arcB</name>
        <name evidence="1" type="ordered locus">TDE_2754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EC" id="4.3.1.12" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973352.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680822.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2754"/>
    <dbReference type="EnsemblBacteria" id="AAS13271">
        <property type="protein sequence ID" value="AAS13271"/>
        <property type="gene ID" value="TDE_2754"/>
    </dbReference>
    <dbReference type="GeneID" id="2740721"/>
    <dbReference type="KEGG" id="tde:TDE_2754"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2600"/>
    <dbReference type="eggNOG" id="COG2423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_3_2_12"/>
    <dbReference type="OMA" id="DMIEPGM"/>
    <dbReference type="OrthoDB" id="1193876at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008473">
        <property type="term" value="F:ornithine cyclodeaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="339" mass="37835" checksum="A897B2F24ACB0C4A" modified="2004-07-05" version="1">MLKTKYIDLPTMAKYLKSVGAETVIKRLVPYLEEDYKRWNDFDKVPRMAHHSPVGVIELMPIGDSKTYSFKYVNGHPENPKHNFLTVMAIGVLAEVCTGFPLLLSELTLTTAVRTAATSVMAAKYLAKPNPKKMALIGNGCQSEFQALGFHHILGVEEIYCYDVDPAATDKLMDNLKDVKGLKLIKCSSTKEACKGVDIITTITADKKNAIIITPDMVEPGMHMNAVGGDCPGKTELDSKVLFMGDVYVEFEPQSRIEGEIQHMDDNFKVTEIWNVIKTGKPINRKPDEITIFDSVGFALEDFSILRLMYDIAKDENVGIPQELVPVLKNPKNLYGMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J54</accession>
    <name>Q73J54_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carhohydrate kinase, FGGY family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973320.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680777.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2722"/>
    <dbReference type="EnsemblBacteria" id="AAS13239">
        <property type="protein sequence ID" value="AAS13239"/>
        <property type="gene ID" value="TDE_2722"/>
    </dbReference>
    <dbReference type="GeneID" id="2740941"/>
    <dbReference type="KEGG" id="tde:TDE_2722"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2571"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_3_12"/>
    <dbReference type="OMA" id="PLEVLHW"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="300"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="402" mass="44528" checksum="D165FAA2A5596FBC" modified="2004-07-05" version="1">MIFCAAVFDIGTSSLKGALIAEDGKVYTQGRLFFPQNLEAETWLISFENLFKQFSDFAEQKSIKICGICISGNGPSLVAVSEDSAERDFLLLWNKASSKASNENSNKNSNENSMKKSPLYGKSIFLPRLDFFRNSYPKIFQSAKYILSGPEYLIYKLTKTKVTVLPEERYVPAYWTDEELKALSIPKNKLAPFVPLGEDCGLYRNIPVFAGPPDFIAALIGTNTLKPGTACDRAGSSEGINICLEAPPESSKLKGLRLLPSPIPNLWNISYLIENSGNVFYEYIKKHGGNFMDFDAFVHNINTKTAHKQNEAEGRSIMEALAFKVKAGMDLLEKAAGFRPIYTISGGQANNKLWRDLKAEITGREFKVLQIADAELLGNAAITFTSLKTYSLISEAASVIVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J56</accession>
    <name>Q73J56_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="5">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973318.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680775.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2720"/>
    <dbReference type="EnsemblBacteria" id="AAS13237">
        <property type="protein sequence ID" value="AAS13237"/>
        <property type="gene ID" value="TDE_2720"/>
    </dbReference>
    <dbReference type="GeneID" id="2740939"/>
    <dbReference type="KEGG" id="tde:TDE_2720"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2569"/>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067442_1_0_12"/>
    <dbReference type="OMA" id="WQTPFLE"/>
    <dbReference type="OrthoDB" id="1490892at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS13237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="278" mass="30843" checksum="1D9E58416B6AB9D0" modified="2004-07-05" version="1">MNIVLFSDDDCAAPDCINDGCVFYKHDKSINNCFVFYKNDERYLHIKKILNLKEGDVFKAGIINGKIGEAQISHLSEEKIVFSFCPNPPDKGIADNGADKVETRPLPLPPIKIILGFPRPIQLRRILRDAASLGFAEIVLCGTDLGERSYLKSNLSSPEEIKKYLLDGISQAGQTMLPAFSFCNSVKEALKDLKAASFKGSKVLLDIGDFPSLSTFRMTKGESVLITIGSERGWTQNERDVFFSEGFIPYSMGKRILRTETALTSALSVLLANNGFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J57</accession>
    <name>Q73J57_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973317.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680773.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2719"/>
    <dbReference type="EnsemblBacteria" id="AAS13236">
        <property type="protein sequence ID" value="AAS13236"/>
        <property type="gene ID" value="TDE_2719"/>
    </dbReference>
    <dbReference type="GeneID" id="2740938"/>
    <dbReference type="KEGG" id="tde:TDE_2719"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2568"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057504_0_2_12"/>
    <dbReference type="OMA" id="YFFKHAH"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="296" mass="34821" checksum="F940EE19D4720BE8" modified="2004-07-05" version="1">MKQLFKITLRNDYAFKRVFGVEENKDVLQDLLECILDIPPETIAGLELLDKEFHKELLSEKLGVLDIKLRLRDGTFIDIEIQNNWHFDFPERTLYYWSKMYNENIKQGQDYTKLPKCITINLIGKGFNKNKRLHNKYLVLEQDTKEPLVSKLEIHILNLEKAKLSKECQFKDNKAKRLLNWLKFIETDNPEVREMLEQESPMMRKANTTIELMEMSPRDKWLYDSRMKYEHDRASCISEGYRQGIEEGIQQGLERGIDKGVYQKALETAKNLLAMNFPIENIAKVTGLSIKEVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JA3</accession>
    <name>Q73JA3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973270.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667136.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2672"/>
    <dbReference type="EnsemblBacteria" id="AAS13189">
        <property type="protein sequence ID" value="AAS13189"/>
        <property type="gene ID" value="TDE_2672"/>
    </dbReference>
    <dbReference type="GeneID" id="2741117"/>
    <dbReference type="KEGG" id="tde:TDE_2672"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2524"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_599761_0_0_12"/>
    <dbReference type="OMA" id="NKFQVRD"/>
    <dbReference type="OrthoDB" id="941291at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Mrr_cat" evidence="4">
        <location>
            <begin position="363"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="446" mass="50744" checksum="5924CD5708F71BC6" modified="2004-07-05" version="1">MVSTIIISFFIIIIAVVILVLVATRSKSPSSGGRKKVKGRAVLMKEASRRLAQNPHDIEGLFIMGDIYYQDQDWEKAYTAYSALLDRMKPLEMNKQLDVAIRYGICALKTNRLPEAKKGFLLAETINPKNLDVSYNLGYIYYLEKDYEKAVKFFKRTLILEPNSFLATKYLGYTLQHLHKYTEALPALKKALDFKPDDKEVLFAMGECFYETEATDRCLKILNHLRVDPVFGPQASLYTGMIRAKADQLERAIEDFQIGLKHTGIPMDISNELKYRLAQAYIKTQEIGQALHLLKEIQSISPGYKDAATLIMRYQELNKNKNLQIYLMSGQSEFVALCRKIVARFYPKAKVKIVDISVLAAYTDIVAEIDTSRFSDTVIFRFFRSQGTVGELLLRELHARLKEVKGGTGICMSAGTFTEEAVRFSEGRPLDLYDKTRLSNVLNSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JA9</accession>
    <name>Q73JA9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, carbon-nitrogen family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973264.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680712.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2666"/>
    <dbReference type="EnsemblBacteria" id="AAS13183">
        <property type="protein sequence ID" value="AAS13183"/>
        <property type="gene ID" value="TDE_2666"/>
    </dbReference>
    <dbReference type="GeneID" id="2741111"/>
    <dbReference type="KEGG" id="tde:TDE_2666"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2519"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099391_0_0_12"/>
    <dbReference type="OMA" id="FPEYCLT"/>
    <dbReference type="OrthoDB" id="1583074at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
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        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="243" mass="27511" checksum="C5761242D8371273" modified="2004-07-05" version="1">MKIGLCASENKNNDIDFNISQIEGFIEKTRSEKPDLLLFGESFLQGFYSLCFEYKKDILTDLQINSEPIAKIRSIAQKEKTAIGFGFIENDHGAIFSSYMIVGKNGEMLCLYKRVSQGWRIEGTCADYREGKEFFEFDFGGKRLAVFICGDLWEDNLLEPIISLNPDAFLWPVFCGYTKEEWKNGEAAAYAERTAILDKPVLFINSLVNENAKAIGGGAFVWHQGKLIKEIPMGETGFLLYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JD3</accession>
    <name>Q73JD3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973240.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2642"/>
    <dbReference type="EnsemblBacteria" id="AAS13159">
        <property type="protein sequence ID" value="AAS13159"/>
        <property type="gene ID" value="TDE_2642"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2642"/>
    <dbReference type="HOGENOM" id="CLU_3174429_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="47" mass="5751" checksum="524EA1F9A42D88B7" modified="2004-07-05" version="1">MMIMSYISFDNITILRLSLYEKKRFFFGIALTFFLDFYIIKTRFTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JP2</accession>
    <name>Q73JP2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973039.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2440"/>
    <dbReference type="EnsemblBacteria" id="AAS12958">
        <property type="protein sequence ID" value="AAS12958"/>
        <property type="gene ID" value="TDE_2440"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2440"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2308"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512803_0_0_12"/>
    <dbReference type="OrthoDB" id="1333447at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="285"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="337"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS12958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="531" mass="60273" checksum="E27B40C3529548E5" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JW5</accession>
    <name>Q73JW5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_2522</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973120.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680485.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2522"/>
    <dbReference type="EnsemblBacteria" id="AAS13039">
        <property type="protein sequence ID" value="AAS13039"/>
        <property type="gene ID" value="TDE_2522"/>
    </dbReference>
    <dbReference type="GeneID" id="2739034"/>
    <dbReference type="KEGG" id="tde:TDE_2522"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2386"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="354"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="388"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS13039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="608" mass="68627" checksum="B816AFADDC9ABC02" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K19</accession>
    <name>Q73K19_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="13">2.7.8.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pgsA</name>
        <name evidence="13" type="ordered locus">TDE_2572</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="13"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973170.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667297.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2572"/>
    <dbReference type="EnsemblBacteria" id="AAS13089">
        <property type="protein sequence ID" value="AAS13089"/>
        <property type="gene ID" value="TDE_2572"/>
    </dbReference>
    <dbReference type="GeneID" id="2739937"/>
    <dbReference type="KEGG" id="tde:TDE_2572"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2431"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_2_3_12"/>
    <dbReference type="OMA" id="FVIFIYR"/>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS13089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="197" mass="22806" checksum="3B066FCCC88889A4" modified="2004-07-05" version="1">MKLSNIFTSSRLVLAPIIYVLYFLPDWIPFISPKITILIIIPIFIFMEFTDFLDGYYARLHNQVDDFGKIFDPFADVVANVTVLFCFLMDGFLFAPFFLIIVYREFGIMFLRMKARGEGITIGAKMGGKTKTVLYIIAASVSMFLKLEKIYTFLPPAISRYILYFNWLLYFAAVILSLASFTDYITSYLNKRRTADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K23</accession>
    <name>Q73K23_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="6">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">thiI</name>
        <name evidence="9" type="ordered locus">TDE_2568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiI family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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        <property type="protein sequence ID" value="AAS13085"/>
        <property type="gene ID" value="TDE_2568"/>
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    <dbReference type="GeneID" id="2739933"/>
    <dbReference type="KEGG" id="tde:TDE_2568"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2427"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_037952_4_0_12"/>
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        <property type="entry name" value="ThiI_AANH"/>
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        <property type="entry name" value="THUMP_dom"/>
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        <property type="entry name" value="tRNA_STrfase"/>
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    <dbReference type="TIGRFAMs" id="TIGR00342">
        <property type="entry name" value="TIGR00342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="8">
        <location>
            <begin position="59"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="206"/>
            <end position="207"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <position position="263"/>
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            <name>ATP</name>
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            <name>ATP</name>
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            <name>ATP</name>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS13085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="387" mass="43479" checksum="B84B4DB70F606748" modified="2004-07-05" version="1">MEELFYLAKIGEINLKKGNLKDFEMRLSQNLRSYLPEAKPNIRVRAGRMYVSIKPEFKEKTEEALNKLIGITGWAQALPAEKTIEAITETARAEAIRARDAGAKTFKIESRRGEKNFPLTSYEISREVGGVIHTEGILKVDVHNPDIVISIEVREKAFIYGLEHKGRRGLPCGCSGRGLLLLSGGIDSPVAGFKMLTRGMKLDYIYFHSHPYTSPEAQAKVEKLADILAGYGLGGYLNIIPFTKVQHQIREKSPEAYLTLMMRICMMKIANMTARGINSKCLITGESLAQVASQTVENLTVTNSYAEFPVFRPLIGLDKEEITIEAKEIGTYETSILPYEDCCVMFSPKHPILHSNLKDAAEIFERMEIDSLLEEAYSQREVKKMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K40</accession>
    <name>Q73K40_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Adenosylcobinamide kinase</fullName>
            <ecNumber evidence="8">2.7.1.156</ecNumber>
            <ecNumber evidence="9">2.7.7.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Adenosylcobinamide-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">cobU</name>
        <name evidence="18" type="ordered locus">TDE_2382</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CobU/CobP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="8"/>
    <dbReference type="EC" id="2.7.7.62" evidence="9"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972981.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680310.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2382"/>
    <dbReference type="EnsemblBacteria" id="AAS12900">
        <property type="protein sequence ID" value="AAS12900"/>
        <property type="gene ID" value="TDE_2382"/>
    </dbReference>
    <dbReference type="GeneID" id="2740684"/>
    <dbReference type="KEGG" id="tde:TDE_2382"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2250"/>
    <dbReference type="eggNOG" id="COG2087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094161_0_2_12"/>
    <dbReference type="OMA" id="DCLTVWL"/>
    <dbReference type="OrthoDB" id="1903913at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043752">
        <property type="term" value="F:adenosylcobinamide kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00544">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 18" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="16">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="31"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AAS12900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="183" mass="20438" checksum="406E18FD515FF89F" modified="2004-07-05" version="1">MITLITGGSRSGKSAYAEKLLDGINDVVYIATAEIYDDEMQERVKRHIKRRNPKWRTYEGFLNLEKAVNGEKYYLLDCITNLISRILFQITGEKEKPSEEEIQKTIDTSLTQIKNLILEIKKINGSLILVTNEVGSSIVPMHPVSRAFSDIQGIVNAKIAELADEVVLCVCGLPIKIKDGASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K62</accession>
    <name>Q73K62_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydroxyacetone kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972959.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674237.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2360"/>
    <dbReference type="EnsemblBacteria" id="AAS12878">
        <property type="protein sequence ID" value="AAS12878"/>
        <property type="gene ID" value="TDE_2360"/>
    </dbReference>
    <dbReference type="GeneID" id="2739969"/>
    <dbReference type="KEGG" id="tde:TDE_2360"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2228"/>
    <dbReference type="eggNOG" id="COG2376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017054_0_0_12"/>
    <dbReference type="OMA" id="DLDWVKW"/>
    <dbReference type="OrthoDB" id="857242at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="1">
        <location>
            <begin position="7"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="335" mass="36453" checksum="4578E52F898B0D55" modified="2004-07-05" version="1">MKKILNRPEEFVDEMVEGILYAYPDKIMPLNGDKRVILNKTKKDNKVGIVTAGGSGHLPVFLGYVGDGMLDGCAVGNVFASPSANKMYEMIKACNFGKGVLCLYGNYGGDKLNFEMAMSMAEMDSIQVKEIRVMDDIASSPIETKDKRRGVAGMVFAYKVAGAAAQKGYDLEKLVSVTEKALDNIRTMGIALSPCIVPEVGKPTFSIKDDEMEIGMGIHGEVGIEVSKLKTSAEVAKMIFDKIATEISFSKNDEVAVMINGLGATPMEELFIVYRDLFNILNGLGVKVISPHVGEFATSMEMAGLSITIMKLDDELKTLLLHDANTPFYTNANKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KB6</accession>
    <name>Y2303_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0102 protein TDE_2303</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_2303</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972903.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675753.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KB6"/>
    <dbReference type="SMR" id="Q73KB6"/>
    <dbReference type="STRING" id="243275.TDE_2303"/>
    <dbReference type="EnsemblBacteria" id="AAS12822">
        <property type="protein sequence ID" value="AAS12822"/>
        <property type="gene ID" value="TDE_2303"/>
    </dbReference>
    <dbReference type="GeneID" id="2740268"/>
    <dbReference type="KEGG" id="tde:TDE_2303"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2173"/>
    <dbReference type="eggNOG" id="COG0792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115353_3_1_12"/>
    <dbReference type="OMA" id="RWRCRWG"/>
    <dbReference type="OrthoDB" id="2044249at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000071105" description="UPF0102 protein TDE_2303">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <sequence length="130" mass="15148" checksum="B4F42B07FF060C10" modified="2004-07-05" version="1">MDSLGSKGESRIAEWLTDKDYLILEKNWRTRTGEIDIIALDKTEQTSSGGILVFIEVKTLLKTELSDLDLIINKKKQERIIKTAKHFLANNRKYNKMYIRFDVIVLRSNPFLEQPLEILHLKDAFGDCYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KD6</accession>
    <name>Q73KD6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA synthetase, class II family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972882.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680171.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2282"/>
    <dbReference type="EnsemblBacteria" id="AAS12801">
        <property type="protein sequence ID" value="AAS12801"/>
        <property type="gene ID" value="TDE_2282"/>
    </dbReference>
    <dbReference type="GeneID" id="2740032"/>
    <dbReference type="KEGG" id="tde:TDE_2282"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2152"/>
    <dbReference type="eggNOG" id="COG2269">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_1_0_12"/>
    <dbReference type="OMA" id="EWYRPGF"/>
    <dbReference type="OrthoDB" id="63621at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="2">
        <location>
            <begin position="14"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="345" mass="39334" checksum="065E856C772F78F8" modified="2004-07-05" version="1">MDIEALELRALSIQAAREFFIKKNYLELDTPALSGELIPETCLEVFKTEYLSPSLLKKSPTGKALFLVPSPEVYIKPIIAQTSRSVFQISKCYRNAESIGNIHSPEFTMLEYYTVNANYKDSVKISEEFLSHVSDRVKENPLVDREVLKTLSKGFECLTMDEAFRKYAGVPLSTEHSPEELAYYAEKLGLGEAENYSDWKEDDLYELILVHAVEPNLPKNRLIAILDYPAFVPCLAAENSKRVLNKKNEALEWKTVERWEVYLNGVELANCYTEERNKSKINSYFKNENELKQKNALVPHPPVKNFGETCSKMSPCSGVAMGFDRLIMLLAGKKTLSPIIYRNNF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KE7</accession>
    <name>IXTPA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="1">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="1">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_2271</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972871.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957197.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KE7"/>
    <dbReference type="SMR" id="Q73KE7"/>
    <dbReference type="STRING" id="243275.TDE_2271"/>
    <dbReference type="EnsemblBacteria" id="AAS12790">
        <property type="protein sequence ID" value="AAS12790"/>
        <property type="gene ID" value="TDE_2271"/>
    </dbReference>
    <dbReference type="GeneID" id="2740021"/>
    <dbReference type="KEGG" id="tde:TDE_2271"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2143"/>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_0_2_12"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000178256" description="dITP/XTP pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <sequence length="194" mass="21244" checksum="F5E475744B6D31B6" modified="2004-07-05" version="1">MKIYLASGNVNKKREVQELLPSHTIVLPKDEGIEFDPEETGSTFFENAMIKAKALYHIVKAPVLADDSGLCVDFLNGAPGIHSARYGSIEGEHVSAEAGINKVLSELKGVKDRSARFACCMVCLLDENRFYSVQETCEGHITEAPSGSGGFGYDPIFFVEKFGKTFAELTSEQKNSISHRGRALFSISRFIKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KE9</accession>
    <name>Q73KE9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2011" name="Proc. Natl. Acad. Sci. U.S.A." volume="108" first="14649" last="14653">
            <title>Conservation of the C-type lectin fold for massive sequence variation in a Treponema diversity-generating retroelement.</title>
            <authorList>
                <person name="Le Coq J."/>
                <person name="Ghosh P."/>
            </authorList>
            <dbReference type="PubMed" id="21873231"/>
            <dbReference type="DOI" id="10.1073/pnas.1105613108"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 39-329 IN COMPLEX WITH CALCIUM</scope>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972869.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680159.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="PDB" id="2Y3C">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.40 A"/>
        <property type="chains" value="A=39-329"/>
    </dbReference>
    <dbReference type="PDBsum" id="2Y3C"/>
    <dbReference type="SMR" id="Q73KE9"/>
    <dbReference type="STRING" id="243275.TDE_2269"/>
    <dbReference type="EnsemblBacteria" id="AAS12788">
        <property type="protein sequence ID" value="AAS12788"/>
        <property type="gene ID" value="TDE_2269"/>
    </dbReference>
    <dbReference type="GeneID" id="2740019"/>
    <dbReference type="KEGG" id="tde:TDE_2269"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2141"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_1_1_12"/>
    <dbReference type="OMA" id="SELMIAV"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284557" description="FGE-sulfatase domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="84"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Calcium</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Calcium</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Calcium</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Calcium</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2Y3C"/>
        </source>
    </evidence>
    <sequence length="329" mass="35604" checksum="DD7FD4F250541EC7" modified="2004-07-05" version="1">MKNTNSKLKTKVLNRAISITALLLAAGVLLTGCPTGQGKSGGGESSEVTPNTPVDKTYTVGSVEFTMKGIAAVNAQLGHNDYSINQPHTVSLSAYLIGETEVTQELWQAVMGNNPSHFNGSPAVGETQGKRPVENVNWYQAIAFCNKLSIKLNLEPCYTVNVGGNPVDFAALSFDQIPDSNNADWDKAELDINKKGFRLPTEAEWEWAAKGGTDDKWSGTNTEAELKNYAWYGSNSGSKTHEVKKKKPNWYGLYDIAGNVAEWCWDWRADIHTGDSFPQDYPGPASGSGRVLRGGSWAGSADYCAVGERVNISPGVRCSDLGFRLACRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KF5</accession>
    <name>Q73KF5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972863.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680147.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2263"/>
    <dbReference type="ESTHER" id="trede-q73kf5">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12782">
        <property type="protein sequence ID" value="AAS12782"/>
        <property type="gene ID" value="TDE_2263"/>
    </dbReference>
    <dbReference type="GeneID" id="2740013"/>
    <dbReference type="KEGG" id="tde:TDE_2263"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2135"/>
    <dbReference type="eggNOG" id="COG0657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012494_13_1_12"/>
    <dbReference type="OMA" id="PHMIHAW"/>
    <dbReference type="OrthoDB" id="1587940at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="72"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="304" mass="33610" checksum="EBCF27B16914F1B5" modified="2004-07-05" version="1">MQNELKDLRELKKKFKKAVLSRKHTIDEIRLAYDDILYSPHVPNNVDLSETELRGVSTDVLKPEMAVSGRVILYAHGGSFISGTKKAYRSFCAGLAHEASADLYLPEYKTAPEYPFPAALEDVYKVYAKLIESRTAEPANLILAGDGAGGGLILSLIHYLKNKRLPLPALLVLFSPWADLSCSSEGLSVNRKKDFVFSQEALLGAAQLYTEEKNLTNELVSPIFGNFENFPPVFIQCGSNEILLDDSIRLCEKIEKAGGRAVLDKIDDMPHLFQAVPDYFSNAHLAVEAVGKKISEFILSGDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KJ2</accession>
    <name>Q73KJ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, substrate-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972826.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675665.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2226"/>
    <dbReference type="EnsemblBacteria" id="AAS12745">
        <property type="protein sequence ID" value="AAS12745"/>
        <property type="gene ID" value="TDE_2226"/>
    </dbReference>
    <dbReference type="GeneID" id="2739502"/>
    <dbReference type="KEGG" id="tde:TDE_2226"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2102"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_1_0_12"/>
    <dbReference type="OMA" id="FHEAFDY"/>
    <dbReference type="OrthoDB" id="1703187at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005701025" evidence="5">
        <location>
            <begin position="22"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="323" mass="36138" checksum="21BC81709918E140" modified="2004-07-05" version="1">MKSILKTCLFIALLSSVNLFAMGAKEIPDNGKKNVAVTFDAMKELTQAVAGDKVNISVIIPPGMEAHDFEPKAKDLAFLSKADILIYNGLGMEFWLDEAVKAVNNKKLIMVEASSGIEAIKAGHHNHDEHGEDCDCEACAGQHKHGKGHEHCHHGEFDPHTWLSLSSAKIMVKNIENALTTADPANAKSYKENASKYIAELDELLKEYIEKFSKVKNKHFVTGHAAFGYLCRDFDLKQNSVTDIFNENEPNPKELAKLIEYCREHNVRVIFTEEAASPLVSKTLATELGAKVEKIYTIESPEDNKSYLERMKTNLMRIYENLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KN2</accession>
    <name>Q73KN2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972786.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674509.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2185"/>
    <dbReference type="EnsemblBacteria" id="AAS12705">
        <property type="protein sequence ID" value="AAS12705"/>
        <property type="gene ID" value="TDE_2185"/>
    </dbReference>
    <dbReference type="GeneID" id="2740207"/>
    <dbReference type="KEGG" id="tde:TDE_2185"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2062"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_648813_0_0_12"/>
    <dbReference type="OMA" id="WVEHYLP"/>
    <dbReference type="OrthoDB" id="1074686at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284573" evidence="1">
        <location>
            <begin position="22"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="414" mass="48048" checksum="100B16CDECB75C3B" modified="2004-07-05" version="1">MKRYILFLILAAMLFTSCTKTEEDKIAVIWTDRAEFVSYCEVFNNSQNKYKIIVEYQKSPVDALINTDVQPDIVIGSWLKGKSARVKFRKINNLFGEKKINKTDFYPELLNLGNISGNQYLLPISFNLPMIIFSSANKFKTKSDFSISPDEIRDFSIKFNKGIKGTYTAMGFSPRWSDDFLYMNTKGFNASFEEEKDFFSWNDKSLQNAINYIRDWSREVNTSAAAEDDFKFKYLYDSPYVLVKNGRCLFYYVSSEELFSTPQKRLENMDFRWLAFSGKTPLKDDILYGGICSKAKNSKAAEAFFIWFFQVKTQEQLLNRANEMDLMINSFGLAGGFSALHQVTEKLFPRYYPLLLAHLPQTQSFYAPHILPSNWPMLKKEILMPYLKDACNASAYPDSIPSLNKRIAEWYKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KS7</accession>
    <name>Q73KS7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protease II</fullName>
            <ecNumber evidence="3">3.4.21.83</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ptrB</name>
        <name evidence="3" type="ordered locus">TDE_2140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.4.21.83" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972741.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679967.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2140"/>
    <dbReference type="ESTHER" id="trede-Q93EK3">
        <property type="family name" value="S9N_PREPL_Peptidase_S9"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.010"/>
    <dbReference type="EnsemblBacteria" id="AAS12660">
        <property type="protein sequence ID" value="AAS12660"/>
        <property type="gene ID" value="TDE_2140"/>
    </dbReference>
    <dbReference type="GeneID" id="2739399"/>
    <dbReference type="KEGG" id="tde:TDE_2140"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2021"/>
    <dbReference type="eggNOG" id="COG1770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011290_0_1_12"/>
    <dbReference type="OMA" id="FPRIAMT"/>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="2">
        <location>
            <begin position="9"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="468"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="685" mass="78415" checksum="0697E222A8CED5E5" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KT0</accession>
    <name>Q73KT0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2137</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972738.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73KT0"/>
    <dbReference type="STRING" id="243275.TDE_2137"/>
    <dbReference type="EnsemblBacteria" id="AAS12657">
        <property type="protein sequence ID" value="AAS12657"/>
        <property type="gene ID" value="TDE_2137"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2137"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2018"/>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000965_2_1_12"/>
    <dbReference type="OMA" id="LDRYPYG"/>
    <dbReference type="OrthoDB" id="231654at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011625">
        <property type="entry name" value="A2M_N_BRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021868">
        <property type="entry name" value="Alpha_2_Macroglob_MG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041203">
        <property type="entry name" value="Bact_A2M_MG5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041462">
        <property type="entry name" value="Bact_A2M_MG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041246">
        <property type="entry name" value="Bact_MG10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00207">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07703">
        <property type="entry name" value="A2M_BRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17973">
        <property type="entry name" value="bMG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11974">
        <property type="entry name" value="bMG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17972">
        <property type="entry name" value="bMG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17962">
        <property type="entry name" value="bMG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01835">
        <property type="entry name" value="MG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07678">
        <property type="entry name" value="TED_complement"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01360">
        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01359">
        <property type="entry name" value="A2M_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="A2M_N_2" evidence="3">
        <location>
            <begin position="968"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="domain" description="A2M" evidence="4">
        <location>
            <begin position="1173"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1834" mass="205348" checksum="12496ABAFED93368" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KU4</accession>
    <name>CLPS_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name type="ordered locus">TDE_2123</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972724.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668196.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KU4"/>
    <dbReference type="SMR" id="Q73KU4"/>
    <dbReference type="STRING" id="243275.TDE_2123"/>
    <dbReference type="EnsemblBacteria" id="AAS12643">
        <property type="protein sequence ID" value="AAS12643"/>
        <property type="gene ID" value="TDE_2123"/>
    </dbReference>
    <dbReference type="GeneID" id="2739382"/>
    <dbReference type="KEGG" id="tde:TDE_2123"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2006"/>
    <dbReference type="eggNOG" id="COG2127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134358_1_0_12"/>
    <dbReference type="OMA" id="NDDYTSM"/>
    <dbReference type="OrthoDB" id="1829294at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000215755" description="ATP-dependent Clp protease adapter protein ClpS">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <sequence length="101" mass="11492" checksum="1D47B22F34CD51F0" modified="2004-07-05" version="1">MELKKQAQKGTIISEKFIEPENYRVILLNDDFTPMDFVVAVLISIFNKSQEEAETLMFKVHKTGQASVGIYVYDIATTKCFQVLTAAKNNNFPLQCKVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KV2</accession>
    <name>Q73KV2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAMP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972716.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2115"/>
    <dbReference type="EnsemblBacteria" id="AAS12635">
        <property type="protein sequence ID" value="AAS12635"/>
        <property type="gene ID" value="TDE_2115"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2115"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1998"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_243603_0_0_12"/>
    <dbReference type="OMA" id="GKEVQKM"/>
    <dbReference type="OrthoDB" id="15371at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="750"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="1097"/>
            <end position="1154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1526" mass="170674" checksum="E1A7C26D3DFE4EB1" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L35</accession>
    <name>Q73L35_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="3">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlpA</name>
        <name evidence="8" type="ordered locus">TDE_2030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the RlpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972633.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679809.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2030"/>
    <dbReference type="EnsemblBacteria" id="AAS12544">
        <property type="protein sequence ID" value="AAS12544"/>
        <property type="gene ID" value="TDE_2030"/>
    </dbReference>
    <dbReference type="GeneID" id="2740377"/>
    <dbReference type="KEGG" id="tde:TDE_2030"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1915"/>
    <dbReference type="eggNOG" id="COG0797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042923_3_3_12"/>
    <dbReference type="OMA" id="AWIRPES"/>
    <dbReference type="OrthoDB" id="2027419at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPBB_1" evidence="6">
        <location>
            <begin position="29"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="7">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="261" mass="29633" checksum="3DF18DB879C248AB" modified="2004-07-05" version="1">MKKTILMLILFLSFMLFLTAQGEIISEETYASYYGEAFNGRPTANGEIFDMNAYTAAHKTLPFGTLVEVTNLENGRKVIVRINDRGPFVGNREIDVSKAAAAALDMLSYGVVRVSLRRIDPNNMGSFTSTETSEKPVNQEKTPVKTEETSSRAKDLVKTKEQDFQALTDSTKNKNLVYMPAKASETEGVLWRIQLGSFKREENALRLVIKLRKIGFEPAYEKTETTTRVVLYGIRPHELEKVKRVLELNSFNDYVLRQESW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L37</accession>
    <name>Q73L37_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OmpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972631.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2028"/>
    <dbReference type="EnsemblBacteria" id="AAS12542">
        <property type="protein sequence ID" value="AAS12542"/>
        <property type="gene ID" value="TDE_2028"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2028"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1913"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005670_0_0_12"/>
    <dbReference type="OMA" id="WDGTDSA"/>
    <dbReference type="OrthoDB" id="87813at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025965">
        <property type="entry name" value="FlgD_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022038">
        <property type="entry name" value="Ig-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13750">
        <property type="entry name" value="Big_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13860">
        <property type="entry name" value="FlgD_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpA-like" evidence="2">
        <location>
            <begin position="1217"/>
            <end position="1338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1338" mass="146671" checksum="1A65E68AB962CF07" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LF7</accession>
    <name>ACPS_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="1">Holo-ACP synthase</shortName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpS</name>
        <name type="ordered locus">TDE_1907</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972510.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679605.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73LF7"/>
    <dbReference type="SMR" id="Q73LF7"/>
    <dbReference type="STRING" id="243275.TDE_1907"/>
    <dbReference type="EnsemblBacteria" id="AAS12421">
        <property type="protein sequence ID" value="AAS12421"/>
        <property type="gene ID" value="TDE_1907"/>
    </dbReference>
    <dbReference type="GeneID" id="2740405"/>
    <dbReference type="KEGG" id="tde:TDE_1907"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1805"/>
    <dbReference type="eggNOG" id="COG0736">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089696_0_2_12"/>
    <dbReference type="OMA" id="LGVRSWH"/>
    <dbReference type="OrthoDB" id="1893660at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000175723" description="Holo-[acyl-carrier-protein] synthase">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <sequence length="123" mass="13264" checksum="91B6E31D11E3E662" modified="2004-07-05" version="1">MILGLGIDIVEVSRLEKWLNDKKLLERFFNKEELEYVLSKRDGAAPSLAVRFAAKEAFGKALGTGLAGIELKDIAVANDKTGRPFLELFGTALQALKEKGGASIHLSLTHEKTTAAAVVIIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LG8</accession>
    <name>Q73LG8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="9">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">IMP cyclohydrolase</fullName>
                <ecNumber evidence="9">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="9">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="9">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">purH</name>
        <name evidence="11" type="ordered locus">TDE_1896</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="9"/>
    <dbReference type="EC" id="3.5.4.10" evidence="9"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972499.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679591.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1896"/>
    <dbReference type="EnsemblBacteria" id="AAS12410">
        <property type="protein sequence ID" value="AAS12410"/>
        <property type="gene ID" value="TDE_1896"/>
    </dbReference>
    <dbReference type="GeneID" id="2739125"/>
    <dbReference type="KEGG" id="tde:TDE_1896"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1795"/>
    <dbReference type="eggNOG" id="COG0138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_5_2_12"/>
    <dbReference type="OMA" id="WRVAKFV"/>
    <dbReference type="OrthoDB" id="1049662at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS12410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="533" mass="57412" checksum="5F35B551FF4ADD7B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LM5</accession>
    <name>Q73LM5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HicB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972441.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669522.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1837"/>
    <dbReference type="EnsemblBacteria" id="AAS12352">
        <property type="protein sequence ID" value="AAS12352"/>
        <property type="gene ID" value="TDE_1837"/>
    </dbReference>
    <dbReference type="GeneID" id="2740499"/>
    <dbReference type="KEGG" id="tde:TDE_1837"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1743"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114047_0_2_12"/>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="134" mass="14966" checksum="D38D0C609AA3398E" modified="2004-07-05" version="1">MKLAYPAIITYCEEDNSYSIEFPDLQGCVSGGFSLIEAIEMGIDAASGWILTEIEEGNAVPKASEPTKIKLPDNKSFINMLILDMDSYSEKYSSKCVRKNITLPKWVNTLAEKNNVNFSQLLQNTIVEKYVGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LN9</accession>
    <name>Q73LN9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972427.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681204.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12338">
        <property type="protein sequence ID" value="AAS12338"/>
        <property type="gene ID" value="TDE_1823"/>
    </dbReference>
    <dbReference type="GeneID" id="2740485"/>
    <dbReference type="KEGG" id="tde:TDE_1823"/>
    <dbReference type="HOGENOM" id="CLU_1947881_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="129" mass="15477" checksum="71208333C5F4F7CC" modified="2004-07-05" version="1">MLTRQNESDRLLKFKEKYKIKQKITSEEKAFSSIAFMKMEYLPKCFDHGAVWRNKDGFLVIEMELYDFDNKIEEDLKIWCKKWKFSYIKENELLPFNCEDGQVIILISNLKSRNKKNLIKNGVIDRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LP2</accession>
    <name>Q73LP2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972424.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957066.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1820"/>
    <dbReference type="EnsemblBacteria" id="AAS12335">
        <property type="protein sequence ID" value="AAS12335"/>
        <property type="gene ID" value="TDE_1820"/>
    </dbReference>
    <dbReference type="GeneID" id="2739250"/>
    <dbReference type="KEGG" id="tde:TDE_1820"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1729"/>
    <dbReference type="eggNOG" id="ENOG502ZBYS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160502_0_0_12"/>
    <dbReference type="OrthoDB" id="1825724at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023811">
        <property type="entry name" value="CHP04076"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04076">
        <property type="entry name" value="TIGR04076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="131" mass="14939" checksum="88196D416A679394" modified="2004-07-05" version="1">MKYKVKLTVIDKKLYPELQKQYCADQNSGVCPCYNVGDEFIFERDEKNDHFWHGGINTLVKTIAEPNTVAGGPKIPHCSEAWDAISRYIYTGLQGGSIMRGWMKEENTMIACCSDGTRPVIFKIERLDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LW7</accession>
    <name>Q73LW7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ordered locus">TDE_1745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972349.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679464.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1745"/>
    <dbReference type="EnsemblBacteria" id="AAS12260">
        <property type="protein sequence ID" value="AAS12260"/>
        <property type="gene ID" value="TDE_1745"/>
    </dbReference>
    <dbReference type="GeneID" id="2740590"/>
    <dbReference type="KEGG" id="tde:TDE_1745"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1668"/>
    <dbReference type="eggNOG" id="COG0799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092688_5_0_12"/>
    <dbReference type="OMA" id="HLMSEKS"/>
    <dbReference type="OrthoDB" id="1990650at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="119" mass="13942" checksum="C475D2BFFB13EB54" modified="2004-07-05" version="1">MIENFDFYTPALELGKLLRDFKGENVVVLDLRDKNIWTDFFVVCTVTSAAHSAGLEKRVYEFLPEHNLEEYHTKRKSPDGDEWRLIDLGGIVVHLMSETARNFYSLEKIWFDSKNILED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LY7</accession>
    <name>Q73LY7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1725</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972329.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12240">
        <property type="protein sequence ID" value="AAS12240"/>
        <property type="gene ID" value="TDE_1725"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1725"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1649"/>
    <dbReference type="eggNOG" id="ENOG503391B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052664_0_0_12"/>
    <dbReference type="OMA" id="MMGTSEL"/>
    <dbReference type="OrthoDB" id="1277675at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="294" mass="33423" checksum="E749D69F760D4061" modified="2004-07-05" version="1">MDLERMSVAISHFPSIHETSILAGQKRSQETLIETLCKTPSDARTLSMPTKAVLGRGFLVAKFHIFSAITKIASNSSFSEEKIEELRAATMNIMFTIMSEDVYISILDSNILDKQKREKVANALTYLWEHRLDQNTTSFAPVLTRVWTARDTIAPVFGTMMGTSELFLLSSKLDDSWQSFMLAKLSNKIIGQSLEEFLFGISYEDILYVRNQLVSCKIPAMGREDVAKLLNKKLDFDNSDPRHFYSSYVQRRNNADARKRLNAAGPKNTIEDYYISFLFEKGLELKDGKAETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M20</accession>
    <name>Q73M20_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972295.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679396.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1691"/>
    <dbReference type="EnsemblBacteria" id="AAS12206">
        <property type="protein sequence ID" value="AAS12206"/>
        <property type="gene ID" value="TDE_1691"/>
    </dbReference>
    <dbReference type="GeneID" id="2740146"/>
    <dbReference type="KEGG" id="tde:TDE_1691"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1618"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057504_0_2_12"/>
    <dbReference type="OMA" id="CYFIKEL"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010106">
        <property type="entry name" value="RpnA"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01784">
        <property type="entry name" value="T_den_put_tspse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="288" mass="34122" checksum="4CDCAEF975607A9D" modified="2004-07-05" version="1">MKKLFKITLRNDYAFKRVFGVEENKDVLQDLLKCILDIQPEDIAGLELLDKELHKDLISDKTGVLDVKLRLKNNTIIDIEIQNRWNSEFVQRTIFYWAKMYTENLKTSEVYTKLPKCITINIVGEGFDLNNLIHSEYNVIEKHINDRLSDELEIHFLNLAKVKEQQESFEQDEKKKKLYNWLKFIKTDNPEVRKMLAESSEMMAKANETIEVMEMSPKEKWLYENRMKYEHDKASWKHVGYQEGIEQGFADGSYQTKLETAKLMKQANCEIDFIMKMTSLSKDEIERI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M27</accession>
    <name>APT_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="1">APRT</shortName>
            <ecNumber evidence="1">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">apt</name>
        <name type="ordered locus">TDE_1684</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972288.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M27"/>
    <dbReference type="SMR" id="Q73M27"/>
    <dbReference type="STRING" id="243275.TDE_1684"/>
    <dbReference type="EnsemblBacteria" id="AAS12199">
        <property type="protein sequence ID" value="AAS12199"/>
        <property type="gene ID" value="TDE_1684"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1684"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1611"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_3_0_12"/>
    <dbReference type="OMA" id="KPGIVFR"/>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00103">
        <property type="entry name" value="PUR_PYR_PR_TRANSFER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0660">Purine salvage</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000149480" description="Adenine phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <sequence length="190" mass="20975" checksum="175661049FE94205" modified="2004-07-05" version="1">MTIAKIRCRLFIMKDKIIDAAIRRVPDFPKKGILFYDITGILVNPEVFSYCLDKMTEMYKDKKVDAVAAIEARGFIFAAPFAYKMGIPLILIRKKGKLPGETYSASYDLEYGQASVEVHKTDVVKGQKVLLLDDLIATGGTLNAARSILEEGGAKVVGFCGVVGLPFLNYSKVLGDLPVKTLIEYDSEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M55</accession>
    <name>Q73M55_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2007 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972260.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679344.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12171">
        <property type="protein sequence ID" value="AAS12171"/>
        <property type="gene ID" value="TDE_1655"/>
    </dbReference>
    <dbReference type="GeneID" id="2738996"/>
    <dbReference type="KEGG" id="tde:TDE_1655"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1582"/>
    <dbReference type="eggNOG" id="ENOG5032GTQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1531860_0_0_12"/>
    <dbReference type="OMA" id="EMEDAFF"/>
    <dbReference type="OrthoDB" id="1728741at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018551">
        <property type="entry name" value="DUF2007"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09413">
        <property type="entry name" value="DUF2007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2007" evidence="1">
        <location>
            <begin position="73"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="176" mass="20056" checksum="3ACC38030C88B5AE" modified="2004-07-05" version="1">MWWLVAVLSGIFVFLFLKKSWKENSEGVKLNDGTAAEDEALDDVVEMEDAFFEAVQSGKKAVKFMHLFYQEDLMMIKSLFQSEHIPYRVENEHVASVLVGYGVTGFNHTDFYILREDYDDAFKIVKEYAENKRLSGKVSGMADKMGAVITVLFASSFIPDKHETSGIVVFKLEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M64</accession>
    <name>Q73M64_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">def</name>
        <name evidence="3" type="ordered locus">TDE_1645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972251.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669259.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1645"/>
    <dbReference type="EnsemblBacteria" id="AAS12162">
        <property type="protein sequence ID" value="AAS12162"/>
        <property type="gene ID" value="TDE_1645"/>
    </dbReference>
    <dbReference type="GeneID" id="2739754"/>
    <dbReference type="KEGG" id="tde:TDE_1645"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1573"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_2_0_12"/>
    <dbReference type="OMA" id="VCIQHEI"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="169" mass="19461" checksum="527E2A913DF5DF9C" modified="2004-07-05" version="1">MKVLYLGEETLREVSKPVEKIDENIKSLIDEMFVTVKKENGIGLAAPQVGENIRLFIVFINEQKYVFINPEIIETSQEMCLMEEGCLSIPKVYDEVMRPSAVKVQFLNIDGKIKTIEASGLLARVIQHENDHLNGILFIDRLSEEKKAEAIEKFEHKKALFSKKRIRLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M65</accession>
    <name>FMT_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fmt</name>
        <name type="ordered locus">TDE_1644</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972250.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679327.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M65"/>
    <dbReference type="SMR" id="Q73M65"/>
    <dbReference type="STRING" id="243275.TDE_1644"/>
    <dbReference type="EnsemblBacteria" id="AAS12161">
        <property type="protein sequence ID" value="AAS12161"/>
        <property type="gene ID" value="TDE_1644"/>
    </dbReference>
    <dbReference type="GeneID" id="2739753"/>
    <dbReference type="KEGG" id="tde:TDE_1644"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1572"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_1_1_12"/>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000083076" description="Methionyl-tRNA formyltransferase">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="115"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <sequence length="322" mass="35400" checksum="BD369336B782DD13" modified="2004-07-05" version="1">MRILFAGTPSCAVPALNLIAREFDLCGVLTNPPAPAGRNKKMQDSDTALAVKELIKEGVLPENFPILTPQKLDDNYRKELEALKSELLVCFAYGKIFGPKTMALFPLGGINIHPSLLPRWRGPAPVPAAILAGDKLTGITIQTLAQKTDCGSILGQLEIPLNDSETTESLLADCADKCCPLLRDVLSDFENKLKQARPQEEAKALYCSMLKKEDGLIDWSKPAEEIERKIRAFTPWPGCFTFKNSEKISIIEANLYEDASNEMTKNKKFGTILGTDKKCGILIQTGNGILAVSVLQKQAKKKLEWKDFLNGSPDFLEGGFET</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M72</accession>
    <name>Q73M72_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA polymerase I</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">polA</name>
        <name evidence="15" type="ordered locus">TDE_1637</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972243.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679321.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1637"/>
    <dbReference type="EnsemblBacteria" id="AAS12154">
        <property type="protein sequence ID" value="AAS12154"/>
        <property type="gene ID" value="TDE_1637"/>
    </dbReference>
    <dbReference type="GeneID" id="2739746"/>
    <dbReference type="KEGG" id="tde:TDE_1637"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1565"/>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004675_0_0_12"/>
    <dbReference type="OMA" id="NRPPMPD"/>
    <dbReference type="OrthoDB" id="1220182at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 11 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="13">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="12">
        <location>
            <begin position="339"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="14">
        <location>
            <begin position="694"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AAS12154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="936" mass="104596" checksum="E0D7A1064EDAB461" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M91</accession>
    <name>Q73M91_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972224.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679305.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12135">
        <property type="protein sequence ID" value="AAS12135"/>
        <property type="gene ID" value="TDE_1618"/>
    </dbReference>
    <dbReference type="GeneID" id="2740859"/>
    <dbReference type="KEGG" id="tde:TDE_1618"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1547"/>
    <dbReference type="eggNOG" id="ENOG5032GI2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069133_0_0_12"/>
    <dbReference type="OMA" id="PWIYSEL"/>
    <dbReference type="OrthoDB" id="1642757at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="278" mass="33151" checksum="1DB3630B30F354EA" modified="2004-07-05" version="1">MYRAFNVHIIDQEMDTLLKNSNQVYDDFLLISHSHKQYIQQSLDNFLLPNNSIDVQSLEQDWFPSVDAHVFISHSHKDIELVQKFEKWLYQQFGIKCFVDSKVWGYANDLLKKLDDKYSLLYSENNINTYYYEKTIISSSHVHMMLATALLKMIDKINYIFFLNTPQSLSLNNIHQFTYSPWIYYELLLLKFIRKNKIKRLTEQEMRQSFSMEAENLAMSFPVDIKNLCKLSRDNLYAWENHMMSHENTPYSALEQLDLLFPDVKLTDNFSKRGRIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MG4</accession>
    <name>Q73MG4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972150.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956987.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1544"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12061">
        <property type="protein sequence ID" value="AAS12061"/>
        <property type="gene ID" value="TDE_1544"/>
    </dbReference>
    <dbReference type="GeneID" id="2740906"/>
    <dbReference type="KEGG" id="tde:TDE_1544"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1480"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_27_5_12"/>
    <dbReference type="OMA" id="EESAKCH"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="186"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="370" mass="40948" checksum="CAAF182432CCEF7B" modified="2004-07-05" version="1">MKIGVDAFGCDHGRSGIGSYILSIVKNLPKNDYEFELFGPELDKYTYTSDIDYVSFTGIDISDTKFSEKIWHFKNLNSFIKKQRYDAVIYPAGVELLPPIFTVPSILVIQSLLSADLGTIAKMGLRRTLKNASGLISPTKYIQNDLSQFGVNASDIKVIYNGIDCSLFKPITNDEDRVLIQPFAIQRPYIIYASRITHEQKCHVELIKAFALFKKQTGSPHRLVIAGSDGNNSEAVHNAVIQSGFSSDILLTGYFPHESLPQLYSSADLCVFPSMIEGVGLPVIEAMACGVPVACARAGALPEVAGDSALFFNSKKPEEIAEAISSLVDCDKNTAKRKEIIEKGLDWVKKYNWETTAHQTIEYIDSLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MG6</accession>
    <name>Q73MG6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972148.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669067.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1542"/>
    <dbReference type="EnsemblBacteria" id="AAS12059">
        <property type="protein sequence ID" value="AAS12059"/>
        <property type="gene ID" value="TDE_1542"/>
    </dbReference>
    <dbReference type="GeneID" id="2740904"/>
    <dbReference type="KEGG" id="tde:TDE_1542"/>
    <dbReference type="eggNOG" id="ENOG5032M4D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206695_0_0_12"/>
    <dbReference type="OrthoDB" id="2083250at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="63" mass="7172" checksum="3A64E8D1F790D640" modified="2004-07-05" version="1">MSETESVSYLFSDNELKQLALYLRKNADSLPRVLEPLSDFAESYVYGRMTIGEAEAFFEQASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MR3</accession>
    <name>Q73MR3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972051.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678060.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1445"/>
    <dbReference type="EnsemblBacteria" id="AAS11962">
        <property type="protein sequence ID" value="AAS11962"/>
        <property type="gene ID" value="TDE_1445"/>
    </dbReference>
    <dbReference type="GeneID" id="2741408"/>
    <dbReference type="KEGG" id="tde:TDE_1445"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1386"/>
    <dbReference type="eggNOG" id="ENOG502ZNJN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1011721_0_0_12"/>
    <dbReference type="OMA" id="NIYLLWT"/>
    <dbReference type="OrthoDB" id="2044000at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="282" mass="31783" checksum="51052ACEA8C3D571" modified="2004-07-05" version="1">MTIAGRNRARLVAICIAALILILSLISFVGIVLNGNLDNSLVTGTKSAESSGITEFILSLLRNNYNGYAVLISILAFPFLSLGFLIFVYFTFKKTHAIEISFFAMFTLCISFESIRLVFPLYSFSNIVLDSIANLSRLVYFFRLAGIMSIFMAGIFANKIITRKISSVFFFIFFISFLICLSMPINNFYISRYFLSDIKAGHSYIYLFLIAALLACVNYFFVYITKNIKEYLFAALSLTGALIGYAVLLYTSSYTLLGIGLALFILGNLSFIKYIHSYHIWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MS9</accession>
    <name>Q73MS9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972034.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679047.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1428"/>
    <dbReference type="EnsemblBacteria" id="AAS11945">
        <property type="protein sequence ID" value="AAS11945"/>
        <property type="gene ID" value="TDE_1428"/>
    </dbReference>
    <dbReference type="GeneID" id="2739705"/>
    <dbReference type="KEGG" id="tde:TDE_1428"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1369"/>
    <dbReference type="eggNOG" id="ENOG5030KXI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047564_0_0_12"/>
    <dbReference type="OrthoDB" id="1408633at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="446" mass="53073" checksum="732C5091769CA013" modified="2004-07-05" version="1">MKYKALPFSILTSTGFGGTGSSAGTNILEEFSSVTSFGNDFECTFLHETDGLFDLEKAFTEGHRLKTDLAIKRFLTLAENLQNEYYYKKYFDNLFYSSAEGFIKSIIDCKWNGWWHRSLETKKISAKEYWRCFFAQLFFEKLYEKKHFSSYEPDSWTPSYHPVSPYYYGFKKDDFYEKAKQYIANVFSNLPVSTKYVVFDQLLPAYSIGNYSRYFDYIKILVIDKDPRDLYSVNKSEWGVGFIPSDVDEFINWYRATRFERYKINTEWKDRALFLPFESLIYDYDASLEKIKTFTGLTTEEHAWKKKYFDPEKSIVNTQVYKRYPALKEDIKKIENELKEFCFPFENYPPISIPEFPDTHIFIEDIQKASEYVQYHGKLPQEYTKKTFSLIVNATHFISTIKSFKVRKTKKLKCKGVIKVCIYLPLFPFEFIFFTFCFFYSRRGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MW4</accession>
    <name>Q73MW4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971998.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678976.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1392"/>
    <dbReference type="EnsemblBacteria" id="AAS11909">
        <property type="protein sequence ID" value="AAS11909"/>
        <property type="gene ID" value="TDE_1392"/>
    </dbReference>
    <dbReference type="GeneID" id="2741259"/>
    <dbReference type="KEGG" id="tde:TDE_1392"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1334"/>
    <dbReference type="eggNOG" id="ENOG5032MAQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1610044_0_0_12"/>
    <dbReference type="OrthoDB" id="2018364at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="163" mass="18352" checksum="644780BF125C6F81" modified="2004-07-05" version="1">MNNSNVEKIKKHLLLFAFFIASGLILWGSGYIISGLKNDAYLQDADYILKNSPLCSKHQGVEFIKALNPSSLNMNFCNAVFEVKMKEKKGYAAFINMSGKYGIYQGMFLYFKEERQCFFCGLGGGIADKPAIYYGIIPLSISISEQKLASAFERLEINNKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MX2</accession>
    <name>Q73MX2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cadmium-translocating P-type ATPase</fullName>
            <ecNumber evidence="7">3.6.3.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cadA</name>
        <name evidence="7" type="ordered locus">TDE_1384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971990.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956962.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1384"/>
    <dbReference type="EnsemblBacteria" id="AAS11901">
        <property type="protein sequence ID" value="AAS11901"/>
        <property type="gene ID" value="TDE_1384"/>
    </dbReference>
    <dbReference type="GeneID" id="2741145"/>
    <dbReference type="KEGG" id="tde:TDE_1384"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1327"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_6_2_12"/>
    <dbReference type="OMA" id="FAQPWET"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="643" mass="69137" checksum="04BDC015A1C54DAA" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MX5</accession>
    <name>VATE_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>V-type ATP synthase subunit E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">V-ATPase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpE</name>
        <name type="ordered locus">TDE_1381</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971987.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678965.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MX5"/>
    <dbReference type="SMR" id="Q73MX5"/>
    <dbReference type="STRING" id="243275.TDE_1381"/>
    <dbReference type="EnsemblBacteria" id="AAS11898">
        <property type="protein sequence ID" value="AAS11898"/>
        <property type="gene ID" value="TDE_1381"/>
    </dbReference>
    <dbReference type="GeneID" id="2741142"/>
    <dbReference type="KEGG" id="tde:TDE_1381"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1325"/>
    <dbReference type="eggNOG" id="COG1390">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105793_0_1_12"/>
    <dbReference type="OMA" id="MQFEVKD"/>
    <dbReference type="OrthoDB" id="1478141at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000322524" description="V-type ATP synthase subunit E">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00311"/>
        </source>
    </evidence>
    <sequence length="205" mass="22142" checksum="28D57981E200CDD8" modified="2004-07-05" version="1">MEVQLQELVDKIKKDGVAAADEKAAEIIRAAEEKAKNIIEKAEAEAQESVKKAEAEALRFQKAAESSIDQAGRNTLISFRQGLLNELNAIIKAETAKNYDSAVLKNLIPEAVKGWVKTGNTENLSVILADKDLKELESSLSAALKDHIAKGMELKADSKIAGGFRIGTKDGSAYYDFSAEAVADLFSSYLSPKTAEILKNAAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MY3</accession>
    <name>Q73MY3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971979.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678955.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1373"/>
    <dbReference type="EnsemblBacteria" id="AAS11890">
        <property type="protein sequence ID" value="AAS11890"/>
        <property type="gene ID" value="TDE_1373"/>
    </dbReference>
    <dbReference type="GeneID" id="2741134"/>
    <dbReference type="KEGG" id="tde:TDE_1373"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1319"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324490_0_0_12"/>
    <dbReference type="OrthoDB" id="1162786at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="33"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="220" mass="25952" checksum="B5253B626B2A04AC" modified="2004-07-05" version="1">MKCEINNILIEKTKAFLKRKFDESKYLSGHPEEKAYRLEHSYRVANIGKAIAEKENFSITEMIIACLLHDISYCEEFCGKEDWLNHGRNAAKISYPFLKELGLPEDRINDICYGIAIHVDDKADFEGERTSFALTVGDADNIDRFDVYRIYETLHNNNFKDMNISLKKDYVEKRLNELYKLLNMELGTKSAEDLWKERLVFYIEFYEKLKEQLKISEDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MY8</accession>
    <name>Q73MY8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971974.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668728.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1368"/>
    <dbReference type="EnsemblBacteria" id="AAS11885">
        <property type="protein sequence ID" value="AAS11885"/>
        <property type="gene ID" value="TDE_1368"/>
    </dbReference>
    <dbReference type="GeneID" id="2741129"/>
    <dbReference type="KEGG" id="tde:TDE_1368"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1314"/>
    <dbReference type="eggNOG" id="ENOG5032TGG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136060_1_0_12"/>
    <dbReference type="OrthoDB" id="1907687at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="122" mass="14412" checksum="7EF6810AD59D170A" modified="2004-07-05" version="1">MELDIKKFWKAIAEQDAEKIRSYFNKTATIRWHNTNEQFTLEEFIKANCEYPGKWEAEVERIQKIENLIITAVKVFNNDTSVHATSFIKIEDDKIIAMDEYWGDDGKPPQWRLDMKIGTAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MZ8</accession>
    <name>Q73MZ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971964.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11875">
        <property type="protein sequence ID" value="AAS11875"/>
        <property type="gene ID" value="TDE_1358"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1358"/>
    <dbReference type="HOGENOM" id="CLU_3391908_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="32" mass="3894" checksum="CF33C364C1F5754A" modified="2004-07-05" version="1">MAFCILKTYFICKASFYKRLGGFQYYFSLKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N31</accession>
    <name>Q73N31_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971931.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1325"/>
    <dbReference type="EnsemblBacteria" id="AAS11842">
        <property type="protein sequence ID" value="AAS11842"/>
        <property type="gene ID" value="TDE_1325"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1325"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1274"/>
    <dbReference type="HOGENOM" id="CLU_3384321_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="33" mass="3852" checksum="EAE4626005954F58" modified="2004-07-05" version="1">MQSTKHHVVVCGLFTNRLKKLFSEIDISCKKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N54</accession>
    <name>Q73N54_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemerythrin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hemerythrin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971908.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671531.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1302"/>
    <dbReference type="EnsemblBacteria" id="AAS11819">
        <property type="protein sequence ID" value="AAS11819"/>
        <property type="gene ID" value="TDE_1302"/>
    </dbReference>
    <dbReference type="GeneID" id="2741056"/>
    <dbReference type="KEGG" id="tde:TDE_1302"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1252"/>
    <dbReference type="eggNOG" id="COG2703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086902_3_1_12"/>
    <dbReference type="OMA" id="MLWKDKY"/>
    <dbReference type="OrthoDB" id="1991725at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12107">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016131">
        <property type="entry name" value="Haemerythrin_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035938">
        <property type="entry name" value="Hemerythrin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012827">
        <property type="entry name" value="Hemerythrin_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47188">
        <property type="entry name" value="SSF47188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02481">
        <property type="entry name" value="hemeryth_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00550">
        <property type="entry name" value="HEMERYTHRINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="4">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="143" mass="17013" checksum="DDB69EBE4044CAA2" modified="2004-07-05" version="1">MSEIKGFEWEDSLSVGYNTIDLHHKKLLTIMGQFKDLFDLPQEEYKLKIGKILKNLSDYTYYHFEEEEKVMKEYGYPYLKEHAEIHKSFIKKIREAIVPLASGNIETGLQFYDFLGRWLVEHIAGADHDWAEYIHKEHPEAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N61</accession>
    <name>Q73N61_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphocarrier protein HPr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ptsH</name>
        <name evidence="2" type="ordered locus">TDE_1294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971901.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668605.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1294"/>
    <dbReference type="EnsemblBacteria" id="AAS11812">
        <property type="protein sequence ID" value="AAS11812"/>
        <property type="gene ID" value="TDE_1294"/>
    </dbReference>
    <dbReference type="GeneID" id="2741048"/>
    <dbReference type="KEGG" id="tde:TDE_1294"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1243"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136230_1_2_12"/>
    <dbReference type="OMA" id="TINIICE"/>
    <dbReference type="OrthoDB" id="404807at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="88" mass="9591" checksum="ED78D258AF4F9200" modified="2004-07-05" version="1">MISKTIKVQNRAGIHARPAALIAQKSNNFSSEIFLCKEDAKINAKSVIGIITMAAAYGTELTLTCDGPDEKEASEAIETIFNNKFEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NC7</accession>
    <name>Q73NC7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971835.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678721.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1228"/>
    <dbReference type="EnsemblBacteria" id="AAS11746">
        <property type="protein sequence ID" value="AAS11746"/>
        <property type="gene ID" value="TDE_1228"/>
    </dbReference>
    <dbReference type="GeneID" id="2741170"/>
    <dbReference type="KEGG" id="tde:TDE_1228"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1183"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109834_0_0_12"/>
    <dbReference type="OMA" id="CAHEGCP"/>
    <dbReference type="OrthoDB" id="1805972at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="175" mass="20358" checksum="BDEE3520EA55AD19" modified="2004-07-05" version="1">MFNFDKKTEYEDFLELLKKSDSLNSLNLSGLEFEGLDFSKKSFTGCTFSNSKFKNCNCSNLHLRMCFFDFCEIDSCNFQNSDIQFSSFGGARIIRTDFKNSELLQNNFNGIRAEDVSYNDSDLYSSRFMFSFLKNVYFQNCNLKKTLFLYSKEDGVSYKSSNTREAVFTEGDEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NI2</accession>
    <name>Q73NI2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971778.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1170"/>
    <dbReference type="EnsemblBacteria" id="AAS11659">
        <property type="protein sequence ID" value="AAS11659"/>
        <property type="gene ID" value="TDE_1170"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1170"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1128"/>
    <dbReference type="HOGENOM" id="CLU_066192_25_0_12"/>
    <dbReference type="OMA" id="CMPSADI"/>
    <dbReference type="OrthoDB" id="2101006at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="120" mass="13401" checksum="E5526BE88F002AEF" modified="2004-07-05" version="1">MAFRENVKKLMDKHGLIAKELALRAKISVNTLNMYLGYKESLPNVDIGVKIAKALDTTVEYLVTGIESSSGIVIAPEDIELIKKIHLLDDIDKKVVEDLIQSFIDRKRSEVSAMETSRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NI5</accession>
    <name>Q73NI5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971775.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956913.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1167"/>
    <dbReference type="EnsemblBacteria" id="AAS11656">
        <property type="protein sequence ID" value="AAS11656"/>
        <property type="gene ID" value="TDE_1167"/>
    </dbReference>
    <dbReference type="GeneID" id="2740064"/>
    <dbReference type="KEGG" id="tde:TDE_1167"/>
    <dbReference type="HOGENOM" id="CLU_2686718_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="74" mass="8641" checksum="65E932D3CA2F498B" modified="2004-07-05" version="1">MKITKNTLIQINSSRHPTFNAIAVKDFDTNDEWYPVSLTDDYLEGMSKYWLKGEEVPCRKSLVRSFKIITEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NJ5</accession>
    <name>Q73NJ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage terminase, large subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971765.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1157"/>
    <dbReference type="EnsemblBacteria" id="AAS11646">
        <property type="protein sequence ID" value="AAS11646"/>
        <property type="gene ID" value="TDE_1157"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1157"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1116"/>
    <dbReference type="eggNOG" id="COG1783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031708_0_0_12"/>
    <dbReference type="OMA" id="IYLCHCK"/>
    <dbReference type="OrthoDB" id="892377at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="417" mass="48409" checksum="868572090EE9F318" modified="2004-07-05" version="1">MDFLAGCNKHRENWRGILFRRTYKELEDIIVRAKELYIPMGAVYKKTDNIFNFPTGSFLRLRYLERDDDVSNYQGHQYTWIGFDELGNYSSDYCWRYMMSRCRSAKGIPCYMRGTGNPGGVGHGWLKKRFIDNQNPNTIYTDEDGNTRCFIPSRLDDNDYLIKNDKGYEKRLRLLPKYLYEALRKGNWDIIAGSAFEEFSRESHVIKPIALDPGVWFKFCSMDWGYSRPFSIGWWAVSRDGRMIRYRELYGCENGEANKGVRRSASSIAKEAYALSIAEGVNTMVADPAVWGKTDDGPTIADKFEVEGWKLIKADNDRINGKMQFHQLLKSKGEDGKPMLLVFDTCFDFIRTIPLLLPSTTRPEDIDTTLEDHIYDETRYAIMSEYARHPGRALEKQNGQWNFKNKRTRGASFDPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NM4</accession>
    <name>Q73NM4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971736.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670701.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1128"/>
    <dbReference type="EnsemblBacteria" id="AAS11617">
        <property type="protein sequence ID" value="AAS11617"/>
        <property type="gene ID" value="TDE_1128"/>
    </dbReference>
    <dbReference type="GeneID" id="2739544"/>
    <dbReference type="KEGG" id="tde:TDE_1128"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1089"/>
    <dbReference type="eggNOG" id="ENOG5033SDH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058631_0_0_12"/>
    <dbReference type="OMA" id="TENANIY"/>
    <dbReference type="OrthoDB" id="674013at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="389" mass="45390" checksum="C86A5CC0B6CA01F6" modified="2004-07-05" version="1">MAASEKKRILDLPLKLILTQEGSTFFIKRNKKLLKFKLAGNIEEYGISLEKFIPETIQRLLLADYISKIEISKPEFVSSRQEVMDLSKLIVYSVLYKQYDDYIFKQILNSPVIKKWNRQNPASIIDEKTHINEKYLANVLQQNEEMIYEAKQEIVKPLFSFITKNNALSPEEKNIQLFLAEKFLNMMRPFTWFIITKFRMHKDFDLILKTIRTSLTEYMDKTKIAEYIALMLMELILSAENMNLRKEALILFPELDDPQEALFDPEIRRRLVAELEKKQELVFVSWKLGSGGVASIGTQGKLQITLYSKNEQSDAVRANLNDLKMADVDKNSLIDFYRALPEGSEDLNLGMYYISYLNDACEKVNVRFESSANRFEDTDLTVMNMSFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NM6</accession>
    <name>Q73NM6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971734.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677638.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1126"/>
    <dbReference type="EnsemblBacteria" id="AAS11615">
        <property type="protein sequence ID" value="AAS11615"/>
        <property type="gene ID" value="TDE_1126"/>
    </dbReference>
    <dbReference type="GeneID" id="2739542"/>
    <dbReference type="KEGG" id="tde:TDE_1126"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1087"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038824_0_0_12"/>
    <dbReference type="OMA" id="NRANTRI"/>
    <dbReference type="OrthoDB" id="1309037at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="170"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="246" mass="27826" checksum="50C81C460D4924B2" modified="2004-07-05" version="1">MKTHFYRLKFKKSIFFAVFLSFFSLLFAVDYFEEGKKLLYADKPQEAVSALFKASQEAGTPKSVYLYLGVAYFRMGKYSEALTYLSQGKDKDILNGHLYYYNIGNVYFLQNQFEASELAYNEAISSNGLYAPAFLNRANTRIKLEKLEGALQDYKIYLNLNPETLQRSSIEKMISLLEGLAEEAERAKALAEAKKAAEEAERLAAEARYKKLMEDVNANLSSVDNADALSAGADNTIDYSEENELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NQ1</accession>
    <name>Q73NQ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971709.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682409.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1101"/>
    <dbReference type="EnsemblBacteria" id="AAS11590">
        <property type="protein sequence ID" value="AAS11590"/>
        <property type="gene ID" value="TDE_1101"/>
    </dbReference>
    <dbReference type="GeneID" id="2740231"/>
    <dbReference type="KEGG" id="tde:TDE_1101"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1060"/>
    <dbReference type="eggNOG" id="ENOG5031D2U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142914_0_0_12"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="159" mass="18786" checksum="356444C86A950809" modified="2004-07-05" version="1">MLKTEKAGIEEAKTILDIYNDSNKVFGVVPEQDIIETFENMIKTENTYILYEDNQAIGFISLKDKNTHGLISAIYIKHKIQRKGYGKYILNFIEQEAKHIGLEYLILKALKMFEWTIEFYKKNSFTIFDKKEDELPFITEYIPPAKWEVIMIKRIMTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P07</accession>
    <name>Q73P07_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0993</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971602.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682308.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0993"/>
    <dbReference type="EnsemblBacteria" id="AAS11483">
        <property type="protein sequence ID" value="AAS11483"/>
        <property type="gene ID" value="TDE_0993"/>
    </dbReference>
    <dbReference type="GeneID" id="2739070"/>
    <dbReference type="KEGG" id="tde:TDE_0993"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.955"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039050_0_0_12"/>
    <dbReference type="OMA" id="RMASWEM"/>
    <dbReference type="OrthoDB" id="995207at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="477" mass="54797" checksum="55769D5F38678727" modified="2004-07-05" version="1">MKITRQIFIYFSFLMAVALFFSCKTTEKAVKSPVTEETKKAEKTGKKSPREEFNDKLTHLSKKGDLEGILKLIDESDPELTKDFKIQYLKLSILISMRKTKEAETFADELSKAYPNNTEILYAQVMLAQAENNTQKKNQYLKKILAINPKDSRALTEQGLDFYSAKKYNDARRKFIEAYKADPKCTEALIGLGRINYLEGKLDQAEANLTAVLEQEPNNSTALAELARIKSETNRMYQALQDINRAAELEPNNPSHWNDIGSYNLTIGRKEEAKKAYDKVIELTPDSYVAYIYRAGINDELGYKEDALADYIKVCNLYPPYYFALEGAGILLWEKGDWLNAGTAFLKALNKAPGSYQYALLYAISLYKQNKKPDAKKFMQNYLKSINRTEKENEYFLCRLFIDFAGDSELINRATAETDMVKKGRLFFYLGEFYNLTKKYTLAEKCYVQVMSIENPAFFEYRFAKKAMDEFNSSNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P10</accession>
    <name>Q73P10_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971599.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0990"/>
    <dbReference type="EnsemblBacteria" id="AAS11480">
        <property type="protein sequence ID" value="AAS11480"/>
        <property type="gene ID" value="TDE_0990"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0990"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.952"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125405_0_0_12"/>
    <dbReference type="OMA" id="YMHEISP"/>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="116" mass="12825" checksum="B14E89D4652FDD1A" modified="2004-07-05" version="1">MPYKLEIIPDTEENGFVASYPELPGCITCGSSLASVVANAEDAKKEWLFAALEEGIPINEPNDIDSYSGQFKLRLPKTLHKTLAEDSKKEGVSMNQYCVYLLSKNSSEHNVLLNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P13</accession>
    <name>Q73P13_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971596.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682300.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73P13"/>
    <dbReference type="STRING" id="243275.TDE_0987"/>
    <dbReference type="EnsemblBacteria" id="AAS11477">
        <property type="protein sequence ID" value="AAS11477"/>
        <property type="gene ID" value="TDE_0987"/>
    </dbReference>
    <dbReference type="GeneID" id="2739064"/>
    <dbReference type="KEGG" id="tde:TDE_0987"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.949"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_12"/>
    <dbReference type="OMA" id="CPIAMDV"/>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="318" mass="35499" checksum="E01AB91607EEEEA2" modified="2004-07-05" version="1">MSKEPIFEVENLVQEFSQGRYSKAVVHALNGVSLSVYEGETLGLVGETGCGKSTLCRAMMRLYKPTSGVIKYRGRDITYLKERKLKDVRSDVQMIFQDPAESMNSRMNVGYVIEEPLIIQTKMTADERKAKVLQLLKDVGLPEDAYYRYPHEFSGGQRQRIAIARALAVDPKIVVCDEPVSALDVSVQSQVLNLLLDMQETRKLTVIFISHGLNVVRHMSDRIAVMYLGSIMELATSSVIYSDPVHPYTQALIAAIPDTDPSKRQKRIPFTGEIPSPINLPSGCPFHLNCTKKIDKCSVEKPVLRDIGDGHMCACHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P60</accession>
    <name>Q73P60_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971549.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682241.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0939"/>
    <dbReference type="EnsemblBacteria" id="AAS11430">
        <property type="protein sequence ID" value="AAS11430"/>
        <property type="gene ID" value="TDE_0939"/>
    </dbReference>
    <dbReference type="GeneID" id="2740972"/>
    <dbReference type="KEGG" id="tde:TDE_0939"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.905"/>
    <dbReference type="eggNOG" id="COG3735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057525_0_1_12"/>
    <dbReference type="OMA" id="VYLELDM"/>
    <dbReference type="OrthoDB" id="1991552at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284627" evidence="1">
        <location>
            <begin position="25"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="311" mass="35379" checksum="69BCB07326C09CF9" modified="2004-07-05" version="1">MKNLKKILTAALAFLLIFSFLVSCKTKDSNSQADGESKAVLIKHPERMFWEVKKGDASIYVLGTIHVADKDFYPLEDKILEAFDKADRRVSELGGKKEMEMVQEKLQIKMLQHFNISPEKDLSNFLSEDKINVVKQELGENIAVPLFKFNPWILTIALNQVLYTKAGLDPQNGIDMHLLNRAGKKNIEALESIDEQLDLLSSGTFEEQLKALKETIKELQNTDKAIDWLTKLKKLYLENNTEELKDFIGSLLDMSDGISQDALLKDRNIVWADKFEEYLNKGGTTFVFAGLAHFLGEDSVFEQMRIKGILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PA2</accession>
    <name>Q73PA2_TREDE</name>
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        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0897</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS11388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0897"/>
    <dbReference type="EnsemblBacteria" id="AAS11388">
        <property type="protein sequence ID" value="AAS11388"/>
        <property type="gene ID" value="TDE_0897"/>
    </dbReference>
    <dbReference type="GeneID" id="2739771"/>
    <dbReference type="KEGG" id="tde:TDE_0897"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.868"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_12"/>
    <dbReference type="OMA" id="LAGCHEF"/>
    <dbReference type="OrthoDB" id="643917at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF90123"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="328"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="369"/>
            <end position="376"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="581" mass="64875" checksum="FE53BCD9283722B8" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PA4</accession>
    <name>Q73PA4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670247.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0895"/>
    <dbReference type="EnsemblBacteria" id="AAS11386">
        <property type="protein sequence ID" value="AAS11386"/>
        <property type="gene ID" value="TDE_0895"/>
    </dbReference>
    <dbReference type="GeneID" id="2739769"/>
    <dbReference type="KEGG" id="tde:TDE_0895"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.865"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865841_0_0_12"/>
    <dbReference type="OMA" id="GYKNATH"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="2">
        <location>
            <begin position="216"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="315" mass="36269" checksum="FE79BCB02C7ADD5F" modified="2004-07-05" version="1">MRTVEDYWEDFEHFGFIKHLKDGRRDYILDEEKGSGGFSILGDTETAVATISDCTLYRPLVIKADNVNERIIELGQYYTGLASYYEKKEKSCEFEYGLNAYVNTFSFYGYKRIEPHVRFINIGFGFREKFFSSLPITLEEDFFERAACVLNPEPIVIPKITAICNSLKECTLEGGALKLYIQGKCLEVFSLLYDYIYKAKPAINVHLSQKDKAVLKEVKTFIEEHFADHVTIAELAKKFAINQQKLVTGFKDCFNATINGYTQKIRMTKALELLYDDTLSIIEIAQAVGYYGDGYFQKAFKETYGITPSRMRRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PF3</accession>
    <name>Q73PF3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971456.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0846"/>
    <dbReference type="EnsemblBacteria" id="AAS11337">
        <property type="protein sequence ID" value="AAS11337"/>
        <property type="gene ID" value="TDE_0846"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0846"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.815"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_382600_0_0_12"/>
    <dbReference type="OMA" id="GFWPGLC"/>
    <dbReference type="OrthoDB" id="194120at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032533">
        <property type="entry name" value="DUF4954"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16314">
        <property type="entry name" value="DUF4954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="720" mass="82259" checksum="E7F9DA8AA77E7010" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PF9</accession>
    <name>Q73PF9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pallilysin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971450.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682100.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0840"/>
    <dbReference type="EnsemblBacteria" id="AAS11331">
        <property type="protein sequence ID" value="AAS11331"/>
        <property type="gene ID" value="TDE_0840"/>
    </dbReference>
    <dbReference type="GeneID" id="2739617"/>
    <dbReference type="KEGG" id="tde:TDE_0840"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.809"/>
    <dbReference type="eggNOG" id="ENOG5034196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042921_0_0_12"/>
    <dbReference type="OrthoDB" id="1165843at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041037">
        <property type="entry name" value="Pallilysin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18663">
        <property type="entry name" value="Pallilysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Pallilysin" evidence="2">
        <location>
            <begin position="255"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="491" mass="56836" checksum="2E9D7B25EE407DB9" modified="2004-07-05" version="1">MFKQIMYAISALIILIVLSFLIYLKFIRSNTKGEEKIVTQTIIPIVSSQIDNENKKTENYSANTETRIFLELSNDETFVDAISDDLNEDGVEDQIIAVKKLLDPFLYLIISIQNPITQKWERVEEIRTTITQPKSLTFYIMNLTQDPKSLIYSGMTSDNRQALSIHTIKKDKGGNVELAQIADLHADMQIQIKEIETQDEVPVSLSSYRIYTYDSDPAAPNTLNQIETEYTWNVKTKKYEEGLKKTIPGEKIEIQLLRKLQSGNMESFIDFLSGLWFQEEGNKETGRSVYFDKNDSHIIFNLDNVEEIYEIKTTLPRRYGLFFTTNNKSIPNIIRRVEIEIKGLDEIQVRVIEDVLRIKFGTASLWNGKYKKNTNLLLNNTNEKESNAEKAKRILSKSSNRWKSANNVFLDLLGNSYTLQQSEDIEKGYFNILEINEKIIMQMKSEKNTTKFYLLEISEKKNMQRMVLTKIKLSINDAIPTGDEPIVFERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PK0</accession>
    <name>Q73PK0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971409.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682054.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0799"/>
    <dbReference type="EnsemblBacteria" id="AAS11290">
        <property type="protein sequence ID" value="AAS11290"/>
        <property type="gene ID" value="TDE_0799"/>
    </dbReference>
    <dbReference type="GeneID" id="2740677"/>
    <dbReference type="KEGG" id="tde:TDE_0799"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.772"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_3_12"/>
    <dbReference type="OMA" id="ELMICTN"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="12"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="259" mass="29627" checksum="1619A83B7BB3A22C" modified="2004-07-05" version="1">MHKEILPNAKRPLLFGHRGVSSLAPENTIASFKKAVELGIPGVELDVHLTKTGELAVIHDSSIKRTGRIYENGKIIEAPDLKVEDLSWEELQKYDFGIWFSKEYEGEKLPLLYDVLKLLGSDIYVDIEIKIDNLKYKGVVEKTYQVLKDILKVLPGNPHRFLVSSFNPFAIRYFSKICSDIPTALIYDNHPDNLFFLKKGRGLLFCRPDILKPSYKCFTKKKDKESWCWTVDDKEKAEGLIKKGVTGIISNRPQDLNQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PK6</accession>
    <name>Q73PK6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971403.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672198.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0793"/>
    <dbReference type="EnsemblBacteria" id="AAS11284">
        <property type="protein sequence ID" value="AAS11284"/>
        <property type="gene ID" value="TDE_0793"/>
    </dbReference>
    <dbReference type="GeneID" id="2740671"/>
    <dbReference type="KEGG" id="tde:TDE_0793"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.766"/>
    <dbReference type="eggNOG" id="ENOG5033FN4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194677_0_0_12"/>
    <dbReference type="OMA" id="KICKFCK"/>
    <dbReference type="OrthoDB" id="2035755at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="71" mass="7665" checksum="D035E3EB2652880B" modified="2004-07-05" version="1">MSKAHRGKGIRAEQNRGRGVCPVCNKTGIKVLYEQEINGAKTKICKICRANIKNKKAAEAPAEKPAEASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PP8</accession>
    <name>Q73PP8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobalamin biosynthesis protein CobN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971360.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682010.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0749"/>
    <dbReference type="EnsemblBacteria" id="AAS11241">
        <property type="protein sequence ID" value="AAS11241"/>
        <property type="gene ID" value="TDE_0749"/>
    </dbReference>
    <dbReference type="GeneID" id="2739868"/>
    <dbReference type="KEGG" id="tde:TDE_0749"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.724"/>
    <dbReference type="eggNOG" id="COG1429">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002017_1_2_12"/>
    <dbReference type="OMA" id="YQFQGGL"/>
    <dbReference type="OrthoDB" id="8025at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051116">
        <property type="term" value="F:cobaltochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10150">
        <property type="entry name" value="CobN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011953">
        <property type="entry name" value="Cobalto_CobN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003672">
        <property type="entry name" value="CobN/Mg_chltase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44119">
        <property type="entry name" value="PTHR44119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02514">
        <property type="entry name" value="CobN-Mg_chel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02257">
        <property type="entry name" value="cobalto_cobN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1244" mass="142740" checksum="6866A9BF973B3145" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PU2</accession>
    <name>Q73PU2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPFH domain/Band 7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971316.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677091.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0704"/>
    <dbReference type="EnsemblBacteria" id="AAS11197">
        <property type="protein sequence ID" value="AAS11197"/>
        <property type="gene ID" value="TDE_0704"/>
    </dbReference>
    <dbReference type="GeneID" id="2739826"/>
    <dbReference type="KEGG" id="tde:TDE_0704"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.682"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_2_2_12"/>
    <dbReference type="OMA" id="AMNMQLK"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="305" mass="34225" checksum="316DB5029C3F71C5" modified="2004-07-05" version="1">MLNFIIPIVIAAIIAIVFIVALFRSIRIVPHKVALIVERLGKYHTTLDAGFHILFPFLDRVKYKQNLKEQAIDVPAQDCFTKDNVQVRIDGILYLQVFDPIKASYGIRDYRYATILLAQTTMRSVVGQLDLDDTFEAREQINAQVVKAVDEASDPWGVKVTRYEIQNIRVSDSIMDAMENQMKAEREKRAEIAHSVGEMETVINLSRAAYEEAVNISEGEKERMINEAEGQAREIVAVAEATADGIKKIAASTQIQGGMEAAKLTVSQEWINALSSIDENTKIIMSADFTDIKKMTIDMAEEIIQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PV6</accession>
    <name>MNMA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="1">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmA</name>
        <name type="ordered locus">TDE_0690</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971302.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681913.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PV6"/>
    <dbReference type="SMR" id="Q73PV6"/>
    <dbReference type="STRING" id="243275.TDE_0690"/>
    <dbReference type="EnsemblBacteria" id="AAS11183">
        <property type="protein sequence ID" value="AAS11183"/>
        <property type="gene ID" value="TDE_0690"/>
    </dbReference>
    <dbReference type="GeneID" id="2740249"/>
    <dbReference type="KEGG" id="tde:TDE_0690"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.670"/>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035188_0_0_12"/>
    <dbReference type="OMA" id="AVCTGHY"/>
    <dbReference type="OrthoDB" id="1054741at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000349850" description="tRNA-specific 2-thiouridylase MnmA">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="1">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="1">
        <location>
            <begin position="302"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Alternate" evidence="1">
        <location>
            <begin position="96"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <sequence length="366" mass="41079" checksum="1B1EA716550E7B98" modified="2004-07-05" version="1">MKVLVGLSGGVDSAVAAKLLIDQGYDVTGVTMQLLPKLSGIYKEQTDDIEDAKKVADKLGIKHIVYDMRETFKTEIIDYFVEEYKQGRTPNPCFICNSKIKFGLFLEQALKDGFDKIATGHYAKIEKTEIEGDERFLLRQAEDAQKDQSYFLALLTQEQLSRSIFPLGDFTKEKVRSIAEDAGLINAHRPDSQDICFVPDDDYTRVINALAAGSFKEGKFIDTMGNEIGRHKGLQYYTIGQRRGLAIAMGYPVYVVKKDAKTNTVTVGKDEELFAESLIASRVNIILKKTIDKEIDIEVKTRYRQQKKKAKLIPLKNEEFKPTGKFKVEFIEPEKAVAEGQAAVFYTGDYIIGGGIIESVERLGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PZ3</accession>
    <name>Q73PZ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971265.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669897.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0652"/>
    <dbReference type="EnsemblBacteria" id="AAS11146">
        <property type="protein sequence ID" value="AAS11146"/>
        <property type="gene ID" value="TDE_0652"/>
    </dbReference>
    <dbReference type="GeneID" id="2740483"/>
    <dbReference type="KEGG" id="tde:TDE_0652"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.632"/>
    <dbReference type="eggNOG" id="ENOG502ZA1I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101764_0_0_12"/>
    <dbReference type="OMA" id="FFAMSIG"/>
    <dbReference type="OrthoDB" id="1522031at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032479">
        <property type="entry name" value="DUF5058"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16481">
        <property type="entry name" value="DUF5058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="244" mass="26040" checksum="6361D501F17F3714" modified="2004-07-05" version="1">MDSYLNVANSWVLWLSAFPLLITVLFQAIIFSKKAKDAAKIVGLSDADVRKSFRIGMTSSIGPVLGVFIVMLGLMSVIGGPLAWMRLSIIGAASTELAAAQMAAQAQGIDLSSPDYGLINFANATWVMALNGSAWLFMTGLFSDKLNSLSKKISKGDPAKLAILMVTAMSGAFGFLCSNEITKALRSVKGKNYPAVAAAVSAALLMVVFEKLGNKYPKLKEYSLGIVMILAMVIAMVFKDLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q27</accession>
    <name>Q73Q27_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971231.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0617"/>
    <dbReference type="EnsemblBacteria" id="AAS11112">
        <property type="protein sequence ID" value="AAS11112"/>
        <property type="gene ID" value="TDE_0617"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0617"/>
    <dbReference type="HOGENOM" id="CLU_3223403_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="44" mass="4785" checksum="D2ABCCD8AD82E83D" modified="2004-07-05" version="1">MMSPNLKGLASIILCIRCGLIKRCNIKKAQGHNTGILLTSCLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q76</accession>
    <name>Q73Q76_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971181.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681736.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0567"/>
    <dbReference type="EnsemblBacteria" id="AAS11062">
        <property type="protein sequence ID" value="AAS11062"/>
        <property type="gene ID" value="TDE_0567"/>
    </dbReference>
    <dbReference type="GeneID" id="2741003"/>
    <dbReference type="KEGG" id="tde:TDE_0567"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.551"/>
    <dbReference type="eggNOG" id="ENOG502ZAD6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073605_0_0_12"/>
    <dbReference type="OMA" id="RFVEAIW"/>
    <dbReference type="OrthoDB" id="499710at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="327" mass="38608" checksum="2D79CD645E7F5D8A" modified="2004-07-05" version="1">MNEIYAINDLSELEDFLHSQNSIENIREKLFAEFLKYADYKSVSEWNKAVRLCECLAVIGWGNHEPLEASRGVFFNGNPRTFFCNRFGELRFVEAIWSKRKTGFTMEQGRTSYYPAPDCKDQKQPVYWDYPVTENIEDIKIESQRNWIPKNPVWIVRTISNCYENSKPVIESIEEKLQDELNKKMRPEKYGKAVNCIFLKCAFSYYDNAHCKTNYVIDESGRKLSSQEAAKELQKLYTKEEISENGYYLRPRFQYGPFKADTGKIEVVIHLEKEFSLLTHHQQKEKLAEYFLIALKTIAEKQKKKTPNYDFNLMISDFTEIAKKWMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q81</accession>
    <name>Q73Q81_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971176.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681730.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0562"/>
    <dbReference type="EnsemblBacteria" id="AAS11057">
        <property type="protein sequence ID" value="AAS11057"/>
        <property type="gene ID" value="TDE_0562"/>
    </dbReference>
    <dbReference type="GeneID" id="2739807"/>
    <dbReference type="KEGG" id="tde:TDE_0562"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.546"/>
    <dbReference type="eggNOG" id="ENOG502ZAP8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1370026_0_0_12"/>
    <dbReference type="OMA" id="IGELEWH"/>
    <dbReference type="OrthoDB" id="1439273at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="200" mass="23038" checksum="FF5C07036B5F6A2B" modified="2004-07-05" version="1">MKIYNITSYAGKDSFAILRPSNKQNIKEVDVLDVWWDDWCSGGDKIGDFVFCYAINVCKNSIFKLLKENFKELKSVELRYNKTDKELNAKNIKRLKWLPKEAIPLTAFFSPISFDCLPQSTIIRSERGIEEIIGVADLRGDVIIPREQGKGLFFSSNVIGDFDFFTLTNSGFLLCTERVKEFCKNQNYENVIFLEMGEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q88</accession>
    <name>Q73Q88_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971169.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681722.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0555"/>
    <dbReference type="EnsemblBacteria" id="AAS11050">
        <property type="protein sequence ID" value="AAS11050"/>
        <property type="gene ID" value="TDE_0555"/>
    </dbReference>
    <dbReference type="GeneID" id="2739800"/>
    <dbReference type="KEGG" id="tde:TDE_0555"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.540"/>
    <dbReference type="eggNOG" id="ENOG5033TB6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1502839_0_0_12"/>
    <dbReference type="OrthoDB" id="1291911at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="179" mass="21065" checksum="505AFA9B896EB1C4" modified="2004-07-05" version="1">MLTLKELIKNQKNFNESFFAEVSDKLWKIGEIEEIKNQTDEDLFLFYIAVNIIGNWKGDGWWEFICNYPQLIRYVPDTLAALKLPDMKAAFENVIKCFPENTVFEYSSTYIDTVNFLQNVRFKISDTYLNSIPADKRKEMSETLHKSIDALESLTDKRWAYDAKDDGWSDVIDFIEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QA3</accession>
    <name>Q73QA3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971154.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0540"/>
    <dbReference type="EnsemblBacteria" id="AAS11035">
        <property type="protein sequence ID" value="AAS11035"/>
        <property type="gene ID" value="TDE_0540"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0540"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.526"/>
    <dbReference type="eggNOG" id="COG5620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064506_0_0_12"/>
    <dbReference type="OMA" id="QDGGNDI"/>
    <dbReference type="OrthoDB" id="568759at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="267" mass="31176" checksum="F87746E22B034856" modified="2004-07-05" version="1">MSIIKSKESNKQDKQPAMPQQKLHINLTKNGLHINGEFIENLSIDILAEKFGEYRKVLRKPPDGTVSKDDLEEIYIWDNMGIRSFVSKGHISELDIRICEDNEWEKKANFSFFDVNPKQVFPGIFTINGKTILEAIPQKTLRDAYIFLKMKVENWEINCSLSSKLNSVLAAISFQERLKKTKTDEIADLVRAEPEPIRDISFWYKPPRVSSGKWKQPKAESKVLTFTNFNFKLAVIQELMYKQELLKPKFDVYDFCNDYAKKRNRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QB2</accession>
    <name>Q73QB2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971145.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0531"/>
    <dbReference type="EnsemblBacteria" id="AAS11026">
        <property type="protein sequence ID" value="AAS11026"/>
        <property type="gene ID" value="TDE_0531"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0531"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.517"/>
    <dbReference type="eggNOG" id="ENOG5032AWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1183593_0_0_12"/>
    <dbReference type="OMA" id="YCERYID"/>
    <dbReference type="OrthoDB" id="1127491at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="222" mass="25567" checksum="F29050682E9E1A42" modified="2004-07-05" version="1">MKTKGIKFLRQASCLETGTKNTYPIRDWFSETKNYTKLFKIVKSEKDPKLLWEYLFLIKTYCERYIDLAYLVKDSQNFISKKENTEFKIKACELGKLFLVHQDASVRQAAASLLWYLKKTSEVWPVIIELMQKKRDYITLSHIGIMVRNCYLLLNDDKIITDSFGNAVAKENLISLKDAEALKEAVSFSLEKTPKAAKKAGFNSVSEILDNIITALTKTVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QI0</accession>
    <name>Q73QI0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uridine phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">deoD</name>
        <name evidence="6" type="ordered locus">TDE_0463</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971077.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681557.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0463"/>
    <dbReference type="EnsemblBacteria" id="AAS10958">
        <property type="protein sequence ID" value="AAS10958"/>
        <property type="gene ID" value="TDE_0463"/>
    </dbReference>
    <dbReference type="GeneID" id="2739217"/>
    <dbReference type="KEGG" id="tde:TDE_0463"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.449"/>
    <dbReference type="eggNOG" id="COG0813">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_2_0_12"/>
    <dbReference type="OMA" id="PQCLLCG"/>
    <dbReference type="OrthoDB" id="1028277at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd09006">
        <property type="entry name" value="PNP_EcPNPI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01627">
        <property type="entry name" value="Pur_nucleosid_phosp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004402">
        <property type="entry name" value="DeoD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43691:SF2">
        <property type="entry name" value="PTHR43691:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00107">
        <property type="entry name" value="deoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="5">
        <location>
            <begin position="16"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="233" mass="25587" checksum="ECE469833097BB06" modified="2004-07-05" version="1">MSVHIAAKQGEIADKILLPGDPLRAEFVANNFLENPQCYNKVRGMLGFTGTYKGVRVSVQGTGMGQPSFSIYANELFNEYGVQRAIRIGTAGALQKDMGLRDVVLAMAASTDSGINTHRFRGCHYAPTADWSLLKNAYDHAQKMGIKPLVGSIASSDVFYDDLETWKMWAAYGVLAVEMEAAELYTLAAKYKRQALAVLTISDNIVTQEQTSAEERQTTFKTMMEIALEAIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QK0</accession>
    <name>Q73QK0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971057.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681524.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0443"/>
    <dbReference type="EnsemblBacteria" id="AAS10938">
        <property type="protein sequence ID" value="AAS10938"/>
        <property type="gene ID" value="TDE_0443"/>
    </dbReference>
    <dbReference type="GeneID" id="2740425"/>
    <dbReference type="KEGG" id="tde:TDE_0443"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.430"/>
    <dbReference type="eggNOG" id="ENOG5031P4K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852437_0_0_12"/>
    <dbReference type="OrthoDB" id="2118385at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="324" mass="38012" checksum="0A3B4BC55A6FE9A1" modified="2004-07-05" version="1">MWNFFTNIKEKFSGINKNYSEKVLNSYTAKLVQVLQSIDNHIEYEIELANNVGLKQDILDKYDPVKYIIELDTQILKKIKNSEKTFYGFYKKAIFLDLSGFKHVNEKIYSELLYRMFEMSASNKNMDVNKFIREFYAYCNKNSFAYAGEEIINRLKKYLQLAEPYIIKTKYEDSSQEDFRSNSGQQENTDFFAETKEDAYGVKLIIDLLFQYNIEDMKSLNKMLKKAGWFHFFVWITLPSVVVILALIAACNDYDHSIYIGIILICAIIVLINSILFAYMSAKIEYLKKSIMKIAIAAKIGENYIYSSLKDQYGKKIKKLLKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QM5</accession>
    <name>Q73QM5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971032.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681456.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0418"/>
    <dbReference type="EnsemblBacteria" id="AAS10913">
        <property type="protein sequence ID" value="AAS10913"/>
        <property type="gene ID" value="TDE_0418"/>
    </dbReference>
    <dbReference type="GeneID" id="2739059"/>
    <dbReference type="KEGG" id="tde:TDE_0418"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.405"/>
    <dbReference type="HOGENOM" id="CLU_059390_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010103">
        <property type="entry name" value="Clustered_lipoprot_TREDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09710">
        <property type="entry name" value="Trep_dent_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285014" evidence="2">
        <location>
            <begin position="24"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="403" mass="47925" checksum="6D72F5BBDDDAC0D5" modified="2004-07-05" version="1">MKKDKLKLIFILMLAAFIFSCSKEVKEPAEEQKPVEAKVETSTKTESQSKETQAKEEKTETKEVINETPAKKAEKEGLKYLSDEKHYMAKGSLLFYNLNINDTYEQALAKLKDFGVNGLYSTAMMPKSLQEMGCKAYIPDDKTLEEDSSNDFYIIFKDDKIIRFIKFFAYNLGFYKFYLPDLEYIYPKIWELEESSGKGYTYFETPDYYSHTAENNVIYRNEIYYPTEATTIIMTRDGYKTYFEEADRRSDDILELGDLYFYDLHIKDDMETIKTKLFNNYIIYKGAGFSPVSDLYYSVYKDNPDGFESRDEEVCVWWYKGKVIHFRTRSSDEDTYILMHHFQRKYKVFEGPGYTGTCYGTRMGRYKYNVWVRKGKDFMFTMEDETAYIENKLWRLKYKNKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QU1</accession>
    <name>Q73QU1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose 5-phosphate isomerase B</fullName>
            <ecNumber evidence="3">5.3.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpiB</name>
        <name evidence="3" type="ordered locus">TDE_0352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970966.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681334.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0352"/>
    <dbReference type="EnsemblBacteria" id="AAS10847">
        <property type="protein sequence ID" value="AAS10847"/>
        <property type="gene ID" value="TDE_0352"/>
    </dbReference>
    <dbReference type="GeneID" id="2740159"/>
    <dbReference type="KEGG" id="tde:TDE_0352"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.341"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_4_1_12"/>
    <dbReference type="OMA" id="DYPPFCL"/>
    <dbReference type="OrthoDB" id="1346802at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="150" mass="15822" checksum="F3C75033D6983DAE" modified="2004-07-05" version="1">MKIGFGSDHSGVALKHILMEHVRNKGYECVDYGAADSKVPANYAEFGLKVAEAIKSQEVEKGVMVCGSGVGISLAANKVPGVRAAACSEPCTAKLAVEHSDINAVAMGVCIVGPEEAKMIVDAFLDARFEGGVYTERVDTLSAIERKYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QV2</accession>
    <name>Q73QV2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="4 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nrdA</name>
        <name evidence="14" type="ordered locus">TDE_0341</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="4 12"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970955.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681315.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0341"/>
    <dbReference type="EnsemblBacteria" id="AAS10836">
        <property type="protein sequence ID" value="AAS10836"/>
        <property type="gene ID" value="TDE_0341"/>
    </dbReference>
    <dbReference type="GeneID" id="2739340"/>
    <dbReference type="KEGG" id="tde:TDE_0341"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.330"/>
    <dbReference type="eggNOG" id="COG0209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_3_0_12"/>
    <dbReference type="OMA" id="RGSIQNI"/>
    <dbReference type="OrthoDB" id="357568at2"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="13">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAS10836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="845" mass="96586" checksum="0DF70D06C09405C8" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QW8</accession>
    <name>Q73QW8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970939.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681285.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10820">
        <property type="protein sequence ID" value="AAS10820"/>
        <property type="gene ID" value="TDE_0325"/>
    </dbReference>
    <dbReference type="GeneID" id="2739332"/>
    <dbReference type="KEGG" id="tde:TDE_0325"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.314"/>
    <dbReference type="eggNOG" id="ENOG502ZZY0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1377591_0_0_12"/>
    <dbReference type="OrthoDB" id="1762430at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285910" evidence="1">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="200" mass="22895" checksum="209C6EE8D34C5429" modified="2004-07-05" version="1">MKKNKLFKILCLLLFIVTGFVFADEEKKALPSKGEVVLVFSLKVLPTPDSAFFSNYRNIKFGNFDFDDGSVATDQIYVNYLVHKYFLSAKCDEDPQKTDFVMKKISLQSNKRIINLYKLVYFFGNAYCAQLTLPIQSELTIPEDVKFVYLGDFTIKCSMPFYDISEIKRIDNFDAAALAVKKAYGKSAELERIPLVPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R06</accession>
    <name>Q73R06_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_0287</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970901.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681228.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0287"/>
    <dbReference type="EnsemblBacteria" id="AAS10782">
        <property type="protein sequence ID" value="AAS10782"/>
        <property type="gene ID" value="TDE_0287"/>
    </dbReference>
    <dbReference type="GeneID" id="2741378"/>
    <dbReference type="KEGG" id="tde:TDE_0287"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.277"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485650_0_0_12"/>
    <dbReference type="OMA" id="VIMISHK"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
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        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="58"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="322"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="354"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="561" mass="64750" checksum="B21E0CB2A0BE5536" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R17</accession>
    <name>Q73R17_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS10771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0276"/>
    <dbReference type="EnsemblBacteria" id="AAS10771">
        <property type="protein sequence ID" value="AAS10771"/>
        <property type="gene ID" value="TDE_0276"/>
    </dbReference>
    <dbReference type="GeneID" id="2741569"/>
    <dbReference type="KEGG" id="tde:TDE_0276"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.268"/>
    <dbReference type="eggNOG" id="COG1896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="AEHSWHF"/>
    <dbReference type="OrthoDB" id="1508841at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="PTHR11845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="29"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="208" mass="24741" checksum="D993433DD2033CAB" modified="2004-07-05" version="1">MESKRIGTFLIDFNQNDKLVNQLNFIIEIDKVKHIFRQSKLFNSERLENDAEHSWTISIMCILLKEYADFEVNIEKVISMLLIHDIVEIDAGDTFLYSSQRDESYNNEKKAADRIFGLLEPDQKKYFLSLWEEFEERKTNEAKFASVFDRLEPIIQNYMSEGYSWKKNNITYDMVINKNMHIKDGSEKIWNFVLQLLEKAVEKGYLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R96</accession>
    <name>Q73R96_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970811.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0195"/>
    <dbReference type="EnsemblBacteria" id="AAS10692">
        <property type="protein sequence ID" value="AAS10692"/>
        <property type="gene ID" value="TDE_0195"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0195"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.191"/>
    <dbReference type="eggNOG" id="COG1670">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_6_12"/>
    <dbReference type="OMA" id="WGSEFQY"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="189" mass="22153" checksum="47F61AD80C48C1AD" modified="2004-07-05" version="1">MKFIHKSYSMFSMKFEPIKTSRLVIVEYAPEYLNEVFAYRSLPEIYKPYTAKIDTPQVLAEYFEEQITEFDNPEGGYSVFLILLNSKVIGEITVSFWDHNNEINEIGFAVHPDYQKQGFASEALKAFIDFLFKKMKRNRIQAGCDYDNIASRKLLEKAGLKMEGHFRKSKYDNGKWVDTCYYAVLRDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R99</accession>
    <name>Q73R99_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970808.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681083.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0192"/>
    <dbReference type="EnsemblBacteria" id="AAS10689">
        <property type="protein sequence ID" value="AAS10689"/>
        <property type="gene ID" value="TDE_0192"/>
    </dbReference>
    <dbReference type="GeneID" id="2741611"/>
    <dbReference type="KEGG" id="tde:TDE_0192"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.188"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094948_0_0_12"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="105"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="254" mass="29207" checksum="67B7C917FDA17DB6" modified="2004-07-05" version="1">MGKYKNQNIIEERIEIEGIPCLRFYPSEISGFVQPFPTVFYYHGWSSEKNKQKLMGYVFSTLGYQVILPDAVHHGERNKFEDYDKALNEFFLPTIMQNLAEFSVLKDYAVKNCNADKNSLAVSGHSMGGFTTAGIFTHNPSVKTAVVFNGACDWQNAILQIEKEYDEAHIEFDEATKKADPAQNIGKLINRPLFLLHGIKDSLVSYKIQKQFYDSTLPLYKNKELLKLMSVERMNHYISIQMLDEAILWLNENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RF4</accession>
    <name>Q73RF4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridine nucleotide-disulphide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970752.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680998.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0135"/>
    <dbReference type="EnsemblBacteria" id="AAS10633">
        <property type="protein sequence ID" value="AAS10633"/>
        <property type="gene ID" value="TDE_0135"/>
    </dbReference>
    <dbReference type="GeneID" id="2741330"/>
    <dbReference type="KEGG" id="tde:TDE_0135"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.135"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030705_0_0_12"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="9"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="456" mass="50035" checksum="716A9F821706ED3C" modified="2004-07-05" version="1">MKALAFTDYDVIVIGGGPAGMAAALAASEKDPKLKIALIEREGQIGGILKQCIHDGFGLIRFKERLTGPEYAWRYKEMTEAKENIDIFLFTFLTKLKKENDLFCMEFTNPEYGIFELKAKSLVAAMGCRERTDRQVNIHGERPAGIFTAGQAQALINLHGFMPGKKCVILGSGDIGLIMARRLTLEGAHVEGVYEIKPTPSGLSRNIVQCLNDYGIPLHLSATVTEVEGRERVEAVKIAQVDKNMKPIAGTEKRIPCDTLILSVGLIPENDILSSLNVPIDGRTKGPIVDQFMHTEAAGLFSCGNALHVNDLVDYVSESGKIAGEAAGDFALNMRAGAEKLFPLKMSTKAKKLLPLNIVGKILYVVPQKIDTEAEGSIIFYFRAAEEMQNTGLSLKADGKTVFERKYEELKPPEMERFILPCEKLRGAEKLEIVLSESPQKGIETSSEKKEADNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RH3</accession>
    <name>Q73RH3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970732.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002691986.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0115"/>
    <dbReference type="EnsemblBacteria" id="AAS10613">
        <property type="protein sequence ID" value="AAS10613"/>
        <property type="gene ID" value="TDE_0115"/>
    </dbReference>
    <dbReference type="GeneID" id="2741730"/>
    <dbReference type="KEGG" id="tde:TDE_0115"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.115"/>
    <dbReference type="eggNOG" id="COG3683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088941_1_0_12"/>
    <dbReference type="OMA" id="HPHMFID"/>
    <dbReference type="OrthoDB" id="1698942at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010412">
        <property type="entry name" value="DUF1007"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06226">
        <property type="entry name" value="DUF1007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="215" mass="25258" checksum="B3F6F3F305FB1F5B" modified="2004-07-05" version="1">MLRSKKNILLFTFLVLINFQSFSHPHMWFTSSLEVIFAGKTLKGAYVTWTFDRFFSADIISGYDLNGDGVFSAAETADVYENAFSYTENYYYFTFIRQGEKRTSPEHIEKASFSVWQNKGIVSYRFFIDLSGFKGQEIFLACYDYTFFCDITYPENTAAKFIYDKSLISPSYSIIENKNYPVYYDPLGAMDDNRIYYKWAPGLNTYYPKEVRIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RH8</accession>
    <name>Q73RH8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">M23/M37 peptidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970727.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666722.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0110"/>
    <dbReference type="EnsemblBacteria" id="AAS10608">
        <property type="protein sequence ID" value="AAS10608"/>
        <property type="gene ID" value="TDE_0110"/>
    </dbReference>
    <dbReference type="GeneID" id="2741725"/>
    <dbReference type="KEGG" id="tde:TDE_0110"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.110"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_2_4_12"/>
    <dbReference type="OMA" id="QWYIHKG"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="235"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="343" mass="38196" checksum="19EE9286B9D11480" modified="2004-07-05" version="1">MSRTRTYKRAENNLVRYFNELFKAFCTSVSKGVMKFINGGRKKLTVMVVPHSQKRIVNFQASIFSIVFVSVLLVGILASFFWFAAESVASARKLANLKEETRKTQASLNVLKNETNDLLKNAKNFQSTLSSTLTSLGLQSIMETGTENDDSSDLSLLFNVQEQAQGTAREVSELKKLSAYLQDTIQPVQEMAKLMDTQTALFSDIPSLWPIKGGIGHITMAFGQNRHPFTGQWYIHTGIDLATGRSGDPIMATADGQVITVETDPGWGNYIIIKHKHGFFTRYAHLSSFRVTRGQHVQKGQVIGYIGNTGISTGPHLHYEVHIGSDVVDPMKYLNIKNTGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RK1</accession>
    <name>Q73RK1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trk system potassium uptake protein TrkA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trkA</name>
        <name evidence="7" type="ordered locus">TDE_0087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970704.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676352.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0087"/>
    <dbReference type="EnsemblBacteria" id="AAS10585">
        <property type="protein sequence ID" value="AAS10585"/>
        <property type="gene ID" value="TDE_0087"/>
    </dbReference>
    <dbReference type="GeneID" id="2741702"/>
    <dbReference type="KEGG" id="tde:TDE_0087"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.88"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_0_3_12"/>
    <dbReference type="OMA" id="IACQVAY"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006036">
        <property type="entry name" value="K_uptake_TrkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00335">
        <property type="entry name" value="KUPTAKETRKA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="2" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="142"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="5">
        <location>
            <begin position="232"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="6">
        <location>
            <begin position="384"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00017378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS10585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="466" mass="51229" checksum="64F56D523F6D2CF7" modified="2004-07-05" version="1">MKIIIVGGGVTGSELARRLIRKKHDVVLIERDEETARHAANRLDCMVVQAAGNDTQILLDAGIKKAEAMIAVTDSDELNMIICGIADSLAPQVIKIARVRNEDYVKALNFSEERTLGINALVYPDEEAALAVIQAIEHGAVSDILSFENSSYELSRFNVCEKSTLDGLAVFDIRKYVDIPFIVVSVEQNGKNRIPSGDTILTAGTRVSILTKPEHIKRFYELSGFETQEFKKIALVGMGRIGKSIAEYLLKNSKGKSFLSKLLPINLNQKWKISIIETNDKKAKEVAAEFPEASIYKADVTDESFVDEIGLDSFDLVICTTPNYEFNMIACAYLKTLGVYKTISLVQSAVLENVAYKIGVDVAVSFKDVVVDSIMSHLVSENVTSVHTMGDGKLEIIELQVSEKSPVLGQKLKDISQHGVYLVLLVTDENGEQIPTGDTEVKAGYKIVFIVKSSRSDEIIKIFGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RK9</accession>
    <name>Q73RK9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970696.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0079"/>
    <dbReference type="EnsemblBacteria" id="AAS10577">
        <property type="protein sequence ID" value="AAS10577"/>
        <property type="gene ID" value="TDE_0079"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0079"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.80"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085376_3_2_12"/>
    <dbReference type="OMA" id="ESHYSHE"/>
    <dbReference type="OrthoDB" id="1292067at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="191" mass="21569" checksum="9621B52F383C5762" modified="2004-07-05" version="1">MDISIGSKIRALRKVRSISLQQMAKDLGMSYSYLSGLENDKYSVSITNLQKIASYFKVNLVSFLTPNGPVPRVFRKKDLYSNANTYDNIAYKVITPESYTHLQVSYAYLPPNEPSERNIHKHGEGQEMVLVLDGCVCVMVEAEKFKIEQGDCIIFDSDAEHLIYTEEQPATLVIVSSPPYGQQILPEKKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RL2</accession>
    <name>Q73RL2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldolase, DeoC/FbaB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970693.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0076"/>
    <dbReference type="EnsemblBacteria" id="AAS10574">
        <property type="protein sequence ID" value="AAS10574"/>
        <property type="gene ID" value="TDE_0076"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0076"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.77"/>
    <dbReference type="eggNOG" id="COG1830">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057069_1_0_12"/>
    <dbReference type="OMA" id="CEYWGMP"/>
    <dbReference type="OrthoDB" id="1560751at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00958">
        <property type="entry name" value="DhnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041720">
        <property type="entry name" value="FbaB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038992">
        <property type="entry name" value="Aldolase_Ia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="265" mass="28750" checksum="F1C1B01625F54056" modified="2004-07-05" version="1">MKGGIMKRRMNNIFRSDGKAFVLALDHAAMMPSPDLHDAGHVIREAVSGGADAFLTTYGMIKNFQKEFGNTGLIMRADGGISSLRKPMDRLDLLYSAEDAVRVGADAMLCMGYPGSTDNEHSLKYLAKLCADGEKFGLPIGAEMLPFGFEKHEGIDTRSIDNIKFACRQGAELGADFVKTEFVGKDDFIGVTESCFAPILVLGGSKAKFEEEIFLDIKSALEAGAKGIIMGRNIYRHSNIARFCEAISIVIHDNASVAEALSILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F7ITJ4</accession>
    <name>F7ITJ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protease complex-associated polypeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prcA</name>
        <name evidence="2" type="ordered locus">TDE_0761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971372.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956812.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0761"/>
    <dbReference type="EnsemblBacteria" id="AAS11253">
        <property type="protein sequence ID" value="AAS11253"/>
        <property type="gene ID" value="TDE_0761"/>
    </dbReference>
    <dbReference type="GeneID" id="2739880"/>
    <dbReference type="KEGG" id="tde:TDE_0761"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.735"/>
    <dbReference type="eggNOG" id="ENOG5032JCI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029356_0_0_12"/>
    <dbReference type="OrthoDB" id="1274747at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003355888" evidence="1">
        <location>
            <begin position="31"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="639" mass="69717" checksum="C70B2884CE1FCFFE" modified="2011-07-27" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F7ITY1</accession>
    <name>F7ITY1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flagellar motor switch protein FliN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fliY</name>
        <name evidence="9" type="ordered locus">TDE_2762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973360.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680828.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2762"/>
    <dbReference type="EnsemblBacteria" id="AAS13279">
        <property type="protein sequence ID" value="AAS13279"/>
        <property type="gene ID" value="TDE_2762"/>
    </dbReference>
    <dbReference type="GeneID" id="2740729"/>
    <dbReference type="KEGG" id="tde:TDE_2762"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2606"/>
    <dbReference type="eggNOG" id="COG1776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033893_0_0_12"/>
    <dbReference type="OMA" id="MMGGDGK"/>
    <dbReference type="OrthoDB" id="1875967at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012826">
        <property type="entry name" value="FliN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001172">
        <property type="entry name" value="FliN_T3SS_HrcQb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00956">
        <property type="entry name" value="FLGMOTORFLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02480">
        <property type="entry name" value="fliN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4 7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="8">
        <location>
            <begin position="315"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS13279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="393" mass="41702" checksum="EF9B924DCC2AA342" modified="2011-07-27" version="1">MSDGSISQDEIDALLSGVGGGGIASAPAAGAGDDLAGFKKTALLQFTKENIPGLSSNLESMTGKSVSISEPVIEFSDRESFLRKVSEMTVATLIDFSGSMSGDHAFMMSPELAKKIVSLVNHEDNVEIDDMALSVISETIAQYVGTELSYLERAGLTGVASSPAESSHVPKAMMRLPQRNFVSITYNVKLDDSAYQLWEILSEDVVDKIASTIAGPDPSMQGMAAMGGMQNMGAMQNNGMMGGMQMGATQTGGPAQQMFGSGMPQGSPQQGGNMQAMNNMGMMPQMGMGASVQPVQFPPLQGFVSQEEQGNIGLIMDVYMEMTVELGRTKRMIKEILGMGEGHIIELDKLAGEPVDVLVNHKPIAKGEVVVIEESFGVRITEILSPAERISDI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-05-10" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>P61191</accession>
    <name>GMSS_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate mutase sigma subunit</fullName>
            <ecNumber evidence="1">5.4.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamate mutase S chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamate mutase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Methylaspartate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmS</name>
        <name type="synonym">mamA</name>
        <name type="ordered locus">TDE_1023</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3S)-3-methyl-L-aspartate = L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12857"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
            <dbReference type="EC" id="5.4.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylaspartate mutase GlmS subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.1" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971631.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670492.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61191"/>
    <dbReference type="SMR" id="P61191"/>
    <dbReference type="STRING" id="243275.TDE_1023"/>
    <dbReference type="EnsemblBacteria" id="AAS11512">
        <property type="protein sequence ID" value="AAS11512"/>
        <property type="gene ID" value="TDE_1023"/>
    </dbReference>
    <dbReference type="GeneID" id="2741502"/>
    <dbReference type="KEGG" id="tde:TDE_1023"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.985"/>
    <dbReference type="eggNOG" id="COG2185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136705_0_0_12"/>
    <dbReference type="OMA" id="GHGEMDC"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="UniPathway" id="UPA00561">
        <property type="reaction ID" value="UER00617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050097">
        <property type="term" value="F:methylaspartate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019670">
        <property type="term" value="P:anaerobic glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019553">
        <property type="term" value="P:glutamate catabolic process via L-citramalate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02072">
        <property type="entry name" value="Glm_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00526">
        <property type="entry name" value="Me_Asp_mutase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006394">
        <property type="entry name" value="GlmS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01501">
        <property type="entry name" value="MthylAspMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0846">Cobalamin</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000216448" description="Glutamate mutase sigma subunit">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="94"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00526"/>
        </source>
    </evidence>
    <sequence length="139" mass="14988" checksum="D43FFA8217AA6F15" modified="2004-05-10" version="1">MARKIKLVLGVIGSDCHAVGNKILDYSLTEAGFEVTNIGVLSPQEDFINAALETNADAILVSSLYGQGELDCKGLREKCDEAGLKGIKLFVGGNIVVGKQNFDEVHKRFTAMGFDHVYPPGTPVETTIKDLHADFPDHA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-05" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>P62421</accession>
    <name>PGK_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="1">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgk</name>
        <name type="ordered locus">TDE_1715</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972319.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679428.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P62421"/>
    <dbReference type="SMR" id="P62421"/>
    <dbReference type="STRING" id="243275.TDE_1715"/>
    <dbReference type="PRIDE" id="P62421"/>
    <dbReference type="EnsemblBacteria" id="AAS12230">
        <property type="protein sequence ID" value="AAS12230"/>
        <property type="gene ID" value="TDE_1715"/>
    </dbReference>
    <dbReference type="GeneID" id="2740887"/>
    <dbReference type="KEGG" id="tde:TDE_1715"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1640"/>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_12"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="462069at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000146029" description="Phosphoglycerate kinase">
        <location>
            <begin position="1"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="20"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="375"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <sequence length="419" mass="45463" checksum="8C0D9AE16A9BE6DD" modified="2004-07-05" version="1">MIKTVKDVNLKDKRIIMRVDFNVPMKDGVVQDDTRIRAALPTIKYILEQGARSLVLMSHLGDPSKDAKKAKEKAEKDGKPFDEEAYINGKHRMKPVAEYLSGLLKLPVDFAPSCMGQLERVKALPQGGILMLENTRFHKEETSKEKAEQQILAKELSLYGDIYVNDAFGTAHRSHASTAEIANFVNTRVAGFLMEKEIKYLEPMLNNPAKPMTAIIGGAKVSSKIAVLESLLKNASSLIIGGGMAYTFLKVQGKKIGKSLFEEDFMDTAKNLLDKAEKQGVKIILPVDHICSETFSPNAEAVLVESTDIPDNLMGMDVGPKTLALYKEIILSSKSIVWNGPVGVFEFEAFSKGTEETARLVAAATEKGALTIVGGGDSVAAVNKFNLADKMSHVSTGGGASLEFLEGKVLPGIACLDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J37</accession>
    <name>Q73J37_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973337.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667028.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2739"/>
    <dbReference type="EnsemblBacteria" id="AAS13256">
        <property type="protein sequence ID" value="AAS13256"/>
        <property type="gene ID" value="TDE_2739"/>
    </dbReference>
    <dbReference type="GeneID" id="2740958"/>
    <dbReference type="KEGG" id="tde:TDE_2739"/>
    <dbReference type="eggNOG" id="COG2510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120467_0_0_12"/>
    <dbReference type="OMA" id="VNSDFAT"/>
    <dbReference type="OrthoDB" id="1668457at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="138" mass="14653" checksum="DBAF364D3DAEFB9D" modified="2004-07-05" version="1">MVWVIFAFLSAVFAALTSILAKVGIEGVNSNLATAVRTAVVLAMAWGMVFITNAQHGIMDISKKSWVFLVLSGLATGASWLCYYKALQAGEASKVVPIDKLSVVITLILAVIFLHENINVKSIIGALLITAGTLCMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J64</accession>
    <name>Q73J64_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973310.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680759.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2712"/>
    <dbReference type="EnsemblBacteria" id="AAS13229">
        <property type="protein sequence ID" value="AAS13229"/>
        <property type="gene ID" value="TDE_2712"/>
    </dbReference>
    <dbReference type="GeneID" id="2740931"/>
    <dbReference type="KEGG" id="tde:TDE_2712"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2561"/>
    <dbReference type="eggNOG" id="ENOG502ZQXU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1546885_0_0_12"/>
    <dbReference type="OrthoDB" id="1690305at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="175" mass="20740" checksum="D55AF291D8898211" modified="2004-07-05" version="1">MKNIKIDFDVLEMMIFFWESVASKDKMGDDYFMSIAEKPQMEVVYSDDFSKDSVRRVMSAISNREKLNNRTLSESRFWNNNMWILEDLQTMHNMMAPIKTLNLAELTEKYKTSTKFDEIELIFIPAHAEEFYIKGNKIYINFFKLIPNYEDPKDIKIAGLPLKEYVIKKIEGLLH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J84</accession>
    <name>PYRG_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTP synthase</fullName>
            <ecNumber evidence="1">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="1">CTP synthetase</shortName>
            <shortName evidence="1">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrG</name>
        <name type="ordered locus">TDE_2692</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973290.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667101.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73J84"/>
    <dbReference type="SMR" id="Q73J84"/>
    <dbReference type="STRING" id="243275.TDE_2692"/>
    <dbReference type="EnsemblBacteria" id="AAS13209">
        <property type="protein sequence ID" value="AAS13209"/>
        <property type="gene ID" value="TDE_2692"/>
    </dbReference>
    <dbReference type="GeneID" id="2739279"/>
    <dbReference type="KEGG" id="tde:TDE_2692"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2542"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_12"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="783657at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000266255" description="CTP synthase">
        <location>
            <begin position="1"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="293"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="1">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="384"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <sequence length="536" mass="60048" checksum="26BB965479D999C3" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J89</accession>
    <name>Q73J89_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-threonine-O-3-phosphate decarboxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973285.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680725.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2687"/>
    <dbReference type="EnsemblBacteria" id="AAS13204">
        <property type="protein sequence ID" value="AAS13204"/>
        <property type="gene ID" value="TDE_2687"/>
    </dbReference>
    <dbReference type="GeneID" id="2739274"/>
    <dbReference type="KEGG" id="tde:TDE_2687"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2539"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_2_12"/>
    <dbReference type="OMA" id="RDPWSVN"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="352" mass="39568" checksum="B3B783605CE2080B" modified="2004-07-05" version="1">MEHGGVLSYKKKDEVLIDFSSNINPLMAPKGLKKALSASFNNLLVYPDIRYRSLKKVTAQYLKCRPENIVLGNGAVEIIDNFCSMFKRVVLCTPCFSEYGLRALVHNKPVLELPYLPDFLPDIAGLEKKLRAGDLLILGNPNNPTGLRIEKTALLQIYSLVQKTGVFLLLDEAFYEFCPPDYDSIALFKKDGYKNICIIRAATKFFGLPGIRLGYACTSTDTAAALSKIEMAWHINAFAEAAAPAIFFDEDFIAKSKAYIQKERVFLLENIEKYGTSGEIKLQTYKSQCNFILLKVLNAKDEDALKFFEKKGILIRTCSSFKTLGDNHIRIAVRSHKDNCKFINAISSKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J95</accession>
    <name>Q73J95_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973278.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680722.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2680"/>
    <dbReference type="EnsemblBacteria" id="AAS13197">
        <property type="protein sequence ID" value="AAS13197"/>
        <property type="gene ID" value="TDE_2680"/>
    </dbReference>
    <dbReference type="GeneID" id="2739267"/>
    <dbReference type="KEGG" id="tde:TDE_2680"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2532"/>
    <dbReference type="eggNOG" id="ENOG5032NXZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122426_0_0_12"/>
    <dbReference type="OMA" id="FFNILMW"/>
    <dbReference type="OrthoDB" id="1573401at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="207" mass="23276" checksum="CE96214EF3BB3787" modified="2004-07-05" version="1">MMTVIAIVLLVLNIFLIFFFYFKFKNQFSDRASINNIKNETQKLVAQIAFQTDQSVTIMEDKIKEVNSLVLELDKRILLAGKEEEKRSAAERVYESLAEAAKANAFSGLDPDAFVKTKKPVISNESVKETERSIEVNKKENPPIDNEPIKIYTKQILAPKSGIVPDQTASMKEQIIEMAKKGLSIELIAEKVPLPTGEIELIISMNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JC4</accession>
    <name>Q73JC4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973249.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680695.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2651"/>
    <dbReference type="EnsemblBacteria" id="AAS13168">
        <property type="protein sequence ID" value="AAS13168"/>
        <property type="gene ID" value="TDE_2651"/>
    </dbReference>
    <dbReference type="GeneID" id="2741096"/>
    <dbReference type="KEGG" id="tde:TDE_2651"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2506"/>
    <dbReference type="eggNOG" id="COG4586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_12"/>
    <dbReference type="OMA" id="DIRTHEF"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="329" mass="38697" checksum="0E2D417011352550" modified="2004-07-05" version="1">MIELKNIDKTYKTQERRFGLLGIVKDMFKPDYSEVKALTDISFKIENNENVAIVGKNGSGKSTLIKIISGILRPTSGEILFNHKNIYENQKEYKRNIGVIFGQRSQLYQNMIFRESLELFRLIYKIEKNEANKRLNTLIDLFKLENLLKKPIREMSLGQKMKCEIALVLFHNPKILLLDEPTIGLDLEVKEQFYNLIKTYKQSNDIILILISHNSDDIINLSERLLVLNNGKLQEDIRTHEFIENYDKSKIVTLLYKKHINLTEKLQSNFNIIDKDLQKNSISFEVDKKITMEEIFNSLDDKENIYDIKIENEDFSKILLNYYKDKKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JD7</accession>
    <name>Q73JD7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5714 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973236.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2638"/>
    <dbReference type="EnsemblBacteria" id="AAS13155">
        <property type="protein sequence ID" value="AAS13155"/>
        <property type="gene ID" value="TDE_2638"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2638"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2494"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093149_0_0_12"/>
    <dbReference type="OMA" id="RCCKRDS"/>
    <dbReference type="OrthoDB" id="1200151at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043768">
        <property type="entry name" value="DUF5714"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18978">
        <property type="entry name" value="DUF5714"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5714" evidence="1">
        <location>
            <begin position="35"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="208" mass="22936" checksum="7B83B18F055C7E69" modified="2004-07-05" version="1">MMECVLCRKKELSKTRCEKGHYVCNECHTKGMDSIIGICLSEKSKNPIEIIEKLMAAPFCHMHGPEHHVMVGSALLTAYKNAGGDIDLEQDLIEMQKRGKSVPGGVCGFWGACGAGISTGMFVSIISKSTPLENEPWGLSNKMTSKSLEAIGNIGGPRCCKRDSYISLLTAIDFIKEIFNINMEKSEIHCTHYTKNNQCIGARCPFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JS2</accession>
    <name>Q73JS2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Modification methylase, HemK family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973086.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680454.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2488"/>
    <dbReference type="EnsemblBacteria" id="AAS13005">
        <property type="protein sequence ID" value="AAS13005"/>
        <property type="gene ID" value="TDE_2488"/>
    </dbReference>
    <dbReference type="GeneID" id="2741461"/>
    <dbReference type="KEGG" id="tde:TDE_2488"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2354"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_3_1_12"/>
    <dbReference type="OMA" id="SYEPQNA"/>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="4">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="329" mass="36779" checksum="4BDEBD8131E0ADD2" modified="2004-07-05" version="1">MLFFTVKDARLFAAHSFLSSLLLTRNGYGRNEALFDADILIAHILKKERSWLLSHSDFDFLPYKNEFEAFVQKRSSGIPIAYLTGTKDFFGRTFYVNENVLIPKPDTETLVELALNFAMEKLKKNEPLFVLDICTGSGCIGLSLAAELYENLSQTSNAFDKPQRAQRTQSYFDRSFFLILADISEEALKVCKKNMDSLLPSALYKRALAVKADLHLPFPCVPEPKRSYDLITANPPYVPSRLTESLLEDGRSEPCLALDGGIEGLDLIPPLAENSYLSLNLGGKLFVEVGEYHAAQAAEIFRSAGFSQVQIHKDLAGNDRVIECTKFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JY1</accession>
    <name>Q73JY1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PIN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973130.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680499.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2532"/>
    <dbReference type="EnsemblBacteria" id="AAS13049">
        <property type="protein sequence ID" value="AAS13049"/>
        <property type="gene ID" value="TDE_2532"/>
    </dbReference>
    <dbReference type="GeneID" id="2739044"/>
    <dbReference type="KEGG" id="tde:TDE_2532"/>
    <dbReference type="eggNOG" id="COG5573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128080_0_0_12"/>
    <dbReference type="OMA" id="WDALILC"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="143" mass="16355" checksum="463FD08E3DF28CAA" modified="2004-07-05" version="1">MSYIVNKIFIDTNILVYALDNRDNDKMNKARNILRKVIYENKPVISTQVINEFYVAATKKLNIDKTLIKTIVHNFKNMEIITSDLQLTENAINISIESQISFWDSLIIAAAEKANCKLIISEDLNSGQTYQGISLINPFQQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JY7</accession>
    <name>Q73JY7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2552</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973150.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2552"/>
    <dbReference type="EnsemblBacteria" id="AAS13069">
        <property type="protein sequence ID" value="AAS13069"/>
        <property type="gene ID" value="TDE_2552"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2552"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2412"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_12"/>
    <dbReference type="OMA" id="MIISEIA"/>
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    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="113"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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        <location>
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    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
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            <end position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="342"/>
            <end position="349"/>
        </location>
        <ligand>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS13069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="524" mass="58615" checksum="64F5DB996CA289E8" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K60</accession>
    <name>Q73K60_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS12880">
        <property type="protein sequence ID" value="AAS12880"/>
        <property type="gene ID" value="TDE_2362"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.2230"/>
    <dbReference type="eggNOG" id="ENOG502ZWQQ">
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    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026002">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="169" mass="19462" checksum="58FC47F92F665586" modified="2004-07-05" version="1">MVITNVKRKSSPALDGQRNICQRRAATISNMIKCAAERGLDKQFARDAIYKYGQDIAASMKKSLKKDFTIDEFLEVFASQPHFDIYEMEVVKKTEDMFLIHFNYCPYVEEWTKQGYCDDELAELCDITMEGDKAIGDCFPNLRFTLGKTIAQGHCVCELLFEKIKETEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K72</accession>
    <name>Q73K72_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667723.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2350"/>
    <dbReference type="EnsemblBacteria" id="AAS12868">
        <property type="protein sequence ID" value="AAS12868"/>
        <property type="gene ID" value="TDE_2350"/>
    </dbReference>
    <dbReference type="GeneID" id="2739959"/>
    <dbReference type="KEGG" id="tde:TDE_2350"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2218"/>
    <dbReference type="eggNOG" id="ENOG503450S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118622_0_0_12"/>
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    <dbReference type="OrthoDB" id="1542115at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="23"/>
        </location>
    </feature>
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        <location>
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            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="202" mass="23068" checksum="FD4291F24F231840" modified="2004-07-05" version="1">MKKNFYFLGLCLVVILIGSCASAPETKPVSAAETQVEEKSQQVQEPAVVEKPVEEAKPKAEAPKTADEEVVAQFEGVSITKKDKEIAKSEIEEVVKKLNEITAKKDYGRWRYWLSKDYIKEFSKPEVLKKTSEGLPSNLKGKQLKSIEDYFYYVFVPSRQNGRVDDIVYLTPTKVRVLKITATQSLIFYNLEKIDDRWLLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K88</accession>
    <name>Q73K88_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972931.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680247.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2332"/>
    <dbReference type="EnsemblBacteria" id="AAS12850">
        <property type="protein sequence ID" value="AAS12850"/>
        <property type="gene ID" value="TDE_2332"/>
    </dbReference>
    <dbReference type="GeneID" id="2739427"/>
    <dbReference type="KEGG" id="tde:TDE_2332"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2201"/>
    <dbReference type="eggNOG" id="ENOG502ZSQB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2620995_0_0_12"/>
    <dbReference type="OMA" id="MERGYAD"/>
    <dbReference type="OrthoDB" id="2027888at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="78" mass="9151" checksum="1A4669D6C37DD208" modified="2004-07-05" version="1">MSYETLVEQIKTLPDVCLEDISKYVQFLMYQYGHEKMSLLKESDEEFEANMNKGFTDMINGNVTPLNDAFEEIKSRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KE6</accession>
    <name>Q73KE6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972872.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680164.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2272"/>
    <dbReference type="EnsemblBacteria" id="AAS12791">
        <property type="protein sequence ID" value="AAS12791"/>
        <property type="gene ID" value="TDE_2272"/>
    </dbReference>
    <dbReference type="GeneID" id="2740022"/>
    <dbReference type="KEGG" id="tde:TDE_2272"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2144"/>
    <dbReference type="eggNOG" id="ENOG5031BUK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_896979_0_0_12"/>
    <dbReference type="OrthoDB" id="1837322at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="342" mass="40745" checksum="8BAFD631F184489E" modified="2004-07-05" version="1">MNFSLEKGEEFVKAYNNDKTNPSRRQKVLMSIFEMIYVNLESFGVYFADEDLRSDFLLKFYYKLPRILENYNSSLSSFYTYLTNHIRFYYLTFKCKTVRHEINDTVLADQEGARWEYLMGEYDLEENFNFYVAESEPEYCNVKTGDLGLKYDKNFSKESMHMRELYFSMPCKHRRIFLLACKACFFLDDDLIDKIAAEIKMDSWFLCSILHDLKAACFNRYEKINYCVGNRNRYYVKAQLFKYLLLHTYNTRSQLKKICFSLKHNRHLWDKTKKINRRQIKAPSSTDIGKYINVYKGTIDKNIAKSLKIWYTQQHENISGIRKCKQKKGSAGASSVSYDRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KH4</accession>
    <name>Q73KH4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972844.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680101.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2244"/>
    <dbReference type="EnsemblBacteria" id="AAS12763">
        <property type="protein sequence ID" value="AAS12763"/>
        <property type="gene ID" value="TDE_2244"/>
    </dbReference>
    <dbReference type="GeneID" id="2741349"/>
    <dbReference type="KEGG" id="tde:TDE_2244"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2118"/>
    <dbReference type="eggNOG" id="ENOG5030SAZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677819_0_0_12"/>
    <dbReference type="OMA" id="RTIKNCE"/>
    <dbReference type="OrthoDB" id="1371646at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="338"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="406" mass="46217" checksum="C4DAD0C85FF5D3B0" modified="2004-07-05" version="1">MNKSDKTIPVLLKELKDLESKLTEAYKQLGNKLIKDTADPVAEANGVSQENFLQWQKLHDERKFCTESVLDIKNNSTRLSELDSFKKQIKDRLSDTKKETEKLKGDFLLKLYKDFLPQCGSIFDSLSAEIHTEEAKIHEAQEKIETLNAEKKEANFFAKIGISGKISSQELKVKNSEKKIKNILTKSDIDIYNSQEVKALYDEDKLFPELKKTYEAILKLGSDLSNSESRLKMIDEETGFVTQKLADAGADKNSKKRIDNFTSRIKEIDEKIDLILESAGIKYTDKFYSAEGDSALGESSSDVELGKYAEYLKKAGKYRKEISKTKYNIEFCETMQKIRAEENQIQNLNRTIKNCENAIKEAEKKIGNSETAIKNSEAKIADLKDFAAGLEEKFLDKTSEQVTEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KM8</accession>
    <name>Q73KM8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">M23/M37 peptidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972790.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680034.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2189"/>
    <dbReference type="EnsemblBacteria" id="AAS12709">
        <property type="protein sequence ID" value="AAS12709"/>
        <property type="gene ID" value="TDE_2189"/>
    </dbReference>
    <dbReference type="GeneID" id="2740211"/>
    <dbReference type="KEGG" id="tde:TDE_2189"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2066"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_5_3_12"/>
    <dbReference type="OMA" id="WELRINE"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="213"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="316" mass="36074" checksum="27DC0A3680BE6D9C" modified="2004-07-05" version="1">MLKKGSFQVLLFFCFLFALHPSGKKEVSDIEQNGKSEKALYIISLPESGDLGSFFNVKFKAARKIEKAWITIYDTSEKKVQTINAFPLDKTEKEWAAIAAVAVWWKSGKWKIRTHLIIDGALFEEDRGFEVLEREFEEYVMKLSKKNSQILRDKSPKKTEQRNRFAEVLKVQNLESLYFKGLFAMPFDAKRISSTFAEKRTSKYPDGKTSVSRHWGIDYPSPIGTPIFAPGTGKVVLAENRIVTGWTLVIEHAPAVYTIYYHLNKIHVKEGSLVKQGEKIADIGTTGFSTGPHLHWELRINEIPADPELLLKKELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KT3</accession>
    <name>Q73KT3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972735.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2134"/>
    <dbReference type="EnsemblBacteria" id="AAS12654">
        <property type="protein sequence ID" value="AAS12654"/>
        <property type="gene ID" value="TDE_2134"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2134"/>
    <dbReference type="HOGENOM" id="CLU_3399006_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="31" mass="3859" checksum="71C27718A4D15821" modified="2004-07-05" version="1">MGNVHPESDFHNLIQFIKTFLYFTIFFKYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KV4</accession>
    <name>Q73KV4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972714.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679924.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2113"/>
    <dbReference type="EnsemblBacteria" id="AAS12633">
        <property type="protein sequence ID" value="AAS12633"/>
        <property type="gene ID" value="TDE_2113"/>
    </dbReference>
    <dbReference type="GeneID" id="2740352"/>
    <dbReference type="KEGG" id="tde:TDE_2113"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1996"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081003_0_0_12"/>
    <dbReference type="OMA" id="KFLAAWV"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025699">
        <property type="entry name" value="ABC2_memb-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13346">
        <property type="entry name" value="ABC2_membrane_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="248" mass="28175" checksum="9A9F1E965FB013F1" modified="2004-07-05" version="1">MNLEKTNKNLIFFITKKEFRMMYKSSSFYAASLFFLAGAAIAFIGSDSWFNAGLSDLKNFFFNMPLLFCVVIPMLTMSSWSDEKKQFTDKFLFSLPVSIRYIVLGKYLSLILIWSIMLALSLVIPLSVFSLAYFDSGSFFVSYISIFLFGAGIISISLGLSAVSGKPEINFLLSFLTVLFFTIIYPLTRNLNFPLLLNEIISYLSFSSHFESAARGLFDSRDIIFYLILVALGIELNVFILTQQRNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KY4</accession>
    <name>Q73KY4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972684.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668265.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2083"/>
    <dbReference type="EnsemblBacteria" id="AAS12603">
        <property type="protein sequence ID" value="AAS12603"/>
        <property type="gene ID" value="TDE_2083"/>
    </dbReference>
    <dbReference type="GeneID" id="2741210"/>
    <dbReference type="KEGG" id="tde:TDE_2083"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1967"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1488387_0_0_12"/>
    <dbReference type="OMA" id="FFNIKDN"/>
    <dbReference type="OrthoDB" id="1225401at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="32"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="183" mass="20218" checksum="0E3924010DFF19CA" modified="2004-07-05" version="1">MSNNSVIAGFDDEKDDSLKIRLQRVDGLDKCVVVFLNGYIDTYNSAFFQKRIAKIIDSGFIQIVFNCAALNYVSSTGIGSFTAFLKTVKPRGGDIVLLDIQPKVYEIFQLLGFSQFFNIKDALSDAVSFFQSSSTTANTKVFPKIFACPICSKKLKATKAGRFRCSECKTILAIDNNAQVFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KZ7</accession>
    <name>Q73KZ7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972671.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957140.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2070"/>
    <dbReference type="EnsemblBacteria" id="AAS12582">
        <property type="protein sequence ID" value="AAS12582"/>
        <property type="gene ID" value="TDE_2070"/>
    </dbReference>
    <dbReference type="GeneID" id="2741197"/>
    <dbReference type="KEGG" id="tde:TDE_2070"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1955"/>
    <dbReference type="eggNOG" id="ENOG5032P03">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064740_0_0_12"/>
    <dbReference type="OMA" id="CANKEAE"/>
    <dbReference type="OrthoDB" id="731392at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="365" mass="41998" checksum="A637FB4792FDF4CB" modified="2004-07-05" version="1">MLLASVLLFAACANKEAEPETVSSEEKTEEETKPISTVWYYFTQDEESESPCLKQTDSPEKVPEQGFRPWTEAVRVSGLGLMYDPPLFLVNKAGILPAFSIEEEPKIEIKNEFYTKTAEGFYKTDLGSLIRLYTNTIFSSILQDESPSSLLRYNSVNGDLLSLIRPEHFKLKNISQLSALEFNKKWFAAFKTEQDGRVEFDYFSFPSFEDLLKENFSVISQEEFINASSPVTLFQDESGIDKIFKMTEKNVKAEMFSEDLKTKQVIFYRNSNTSYAGDFEITASVCEFTPENDQKTLKAVLLETGRLFYTDPETQEWVETALPVLPEGFIYTYFVIRKDIIISAWEEQRFFETGRSGLIVYKIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L04</accession>
    <name>Q73L04_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972664.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679856.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2062"/>
    <dbReference type="EnsemblBacteria" id="AAS12575">
        <property type="protein sequence ID" value="AAS12575"/>
        <property type="gene ID" value="TDE_2062"/>
    </dbReference>
    <dbReference type="GeneID" id="2741189"/>
    <dbReference type="KEGG" id="tde:TDE_2062"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1946"/>
    <dbReference type="eggNOG" id="ENOG5030U0Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1495559_0_0_12"/>
    <dbReference type="OrthoDB" id="1903230at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284919" evidence="3">
        <location>
            <begin position="20"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="180" mass="18775" checksum="36B7549FE748BF94" modified="2004-07-05" version="1">MKKIFIVFVLMMCSIMLFAHSPLLTVEDNGDGTIYVQGGFSNGASAAGVKLYLTDKASGQKIWEGEFPDVGELNLPIPNVPYTVTFDAGPGHIIVKDGPEPEGGFGSQAASSEAAGENESAGDVAQAQKPVAVSGSAGWVPMDTVSAMPSVGPSFTAILALVLAVINSILIVFLFKKQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L13</accession>
    <name>Q73L13_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NifU domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972655.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668316.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2053"/>
    <dbReference type="EnsemblBacteria" id="AAS12566">
        <property type="protein sequence ID" value="AAS12566"/>
        <property type="gene ID" value="TDE_2053"/>
    </dbReference>
    <dbReference type="GeneID" id="2740647"/>
    <dbReference type="KEGG" id="tde:TDE_2053"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1938"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_4_0_12"/>
    <dbReference type="OMA" id="MKLDSMY"/>
    <dbReference type="OrthoDB" id="1793654at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="144" mass="16393" checksum="C4255D733864114C" modified="2004-07-05" version="1">MDIDTIYQEMILEYSRKKENCRELSGEGVKIERGHNPSCGDDLTLLIREKDGIIEDASFLGRGCAISTASTNMLIELIKGKNAEEGKRKVEIFFKMMNGKEISEEEKEELEDAQILEYFAEMPARIKCATLSWHSADVLLNEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L44</accession>
    <name>Q73L44_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972624.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674857.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2021"/>
    <dbReference type="EnsemblBacteria" id="AAS12535">
        <property type="protein sequence ID" value="AAS12535"/>
        <property type="gene ID" value="TDE_2021"/>
    </dbReference>
    <dbReference type="GeneID" id="2740368"/>
    <dbReference type="KEGG" id="tde:TDE_2021"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1907"/>
    <dbReference type="HOGENOM" id="CLU_1365715_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="200" mass="24363" checksum="03E2625CCC31681D" modified="2004-07-05" version="1">MKRLFIFIFCSAGLQVLFSQSISIEKIYQTQKDVFIDIYLETDKKIKVSEYDIQMENDQYITPFGASQRNYICIYKKNEDNSYQLILTNWFYDEIYEYLKYYIVIPRNGIKYNLVEFSGCKNIIIHIPRCYNNETEYRKITSVKVVFFYNIDYEKYEILKTEKKCDITVYDLRNVYWKNEYCSEQLFDESGYIDLNKLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L60</accession>
    <name>Q73L60_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972608.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2005"/>
    <dbReference type="EnsemblBacteria" id="AAS12519">
        <property type="protein sequence ID" value="AAS12519"/>
        <property type="gene ID" value="TDE_2005"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2005"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1893"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_6_0_12"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="184" mass="21101" checksum="6B3FD93FE9D5CD52" modified="2004-07-05" version="1">MRSIAAMTGITAGALYKHFPSKAAIFEALVQPLIGQTLSIGSDFSEIAIHLYETKDFLSTKEAIRISLQNLCTLVYSRFDDFRLLFNRSAGTKYENIRHDFVMADVTACKKFIADLKKRGINVRPLNDDQLHLIYSTALTPLFEIITHEYSYKKALSFIDILTDVMYFCWNKIMQPETEINKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L83</accession>
    <name>Q73L83_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972585.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12496">
        <property type="protein sequence ID" value="AAS12496"/>
        <property type="gene ID" value="TDE_1982"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1982"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1871"/>
    <dbReference type="HOGENOM" id="CLU_1677084_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="157" mass="17420" checksum="02AF05850B87AFD6" modified="2004-07-05" version="1">MPAVRLEASLAVLPLIYSFSISSSGRPVTCIIFCIESPNYFNIVAVSIDFCFKPSEKPLYLASISKVDINLYSCLACSFCFTVCIISSILLVNSLFVLPVLRYSKNSFNSLFSVFLNASAFIITSKRGRGTPPFPYGLFKSGRWFYLETPLVVPLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LB7</accession>
    <name>Q73LB7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972551.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679664.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1948"/>
    <dbReference type="EnsemblBacteria" id="AAS12462">
        <property type="protein sequence ID" value="AAS12462"/>
        <property type="gene ID" value="TDE_1948"/>
    </dbReference>
    <dbReference type="GeneID" id="2740188"/>
    <dbReference type="KEGG" id="tde:TDE_1948"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1840"/>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_2_12"/>
    <dbReference type="OMA" id="MFNFIAA"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="365" mass="39278" checksum="37AC0466056A4FE5" modified="2004-07-05" version="1">MSKLKIRFKDFNIAENNFIISFSAVLLGLIAGAVFIAVSGTNPFSAFSYLFRGGLMNIERIGNTLATATILLFVGLSVSFAFKTGLFNIGASGQMLIGGLFATFIALNSSMPRPVLLLVLIIAAMIGGAFWAALPGLLKAVFNVHEVVSTIMMNWIAYWIVYYSVQGYLKAEFIETESRSIAVEHTLRAGWLSNLFGSEYINYGIFLGILGIILVKIILDKTTLGFELKAAGYNKSGAEYAGIKVNRNIIFSMMIAGALSGLAGLTYYAGYSLNMQIGVLPSQGFDGIAVALLGAGNSIGVALSSIFFGILHVGKGFMSANTNVPPEIADTIIAVIIYFTATSLLLKKFWSKIQKNKEKTVKEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LD0</accession>
    <name>Q73LD0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972538.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1935"/>
    <dbReference type="EnsemblBacteria" id="AAS12449">
        <property type="protein sequence ID" value="AAS12449"/>
        <property type="gene ID" value="TDE_1935"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1935"/>
    <dbReference type="HOGENOM" id="CLU_3405978_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="30" mass="3543" checksum="82E6B8D6EBA56E81" modified="2004-07-05" version="1">MRMEPLEIYGIVVFFSVANVLFFVYNITDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LD9</accession>
    <name>Q73LD9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972529.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1926"/>
    <dbReference type="EnsemblBacteria" id="AAS12440">
        <property type="protein sequence ID" value="AAS12440"/>
        <property type="gene ID" value="TDE_1926"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1926"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1821"/>
    <dbReference type="eggNOG" id="COG4769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044846_0_0_12"/>
    <dbReference type="OMA" id="IWVAAPL"/>
    <dbReference type="OrthoDB" id="1261544at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010898">
        <property type="entry name" value="Hpre_diP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07456">
        <property type="entry name" value="Hpre_diP_synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="362" mass="40695" checksum="2DC176126CC06898" modified="2004-07-05" version="1">MRLRVLRLSLKTKKADTLIPLFGGFCFFLSAIEIMIPKPVPFFRIGLANLPVILGIDLFSFPAFVLLLVIKVLGQALISGTLFSYIVLFSAIGTFSSGLLMYAMRKIPRKTISFMGISLAGAFVSNSLQFLLAVLLMFGKSAVYIIPPVFSLGTLTALFLGWFASEFEIQSVWYQRVKAERFDFVPDNSQAVRHYKSENESEKTKSRTLRDRYLRIGSGISLFLILLFVPFLPVQALVLGAALILCAADKQKLNFLNLIFMFTAITVFNLFPPMGKIIFSIGSIDITHQALLRGFEKAIVLLGMIYISKWMLKAKMNFKSRIGKSIQEAFDVFYKLLSVKHEIKPKMIIPTIDSVLLSINRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LI7</accession>
    <name>Q73LI7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1875</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972479.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1875"/>
    <dbReference type="EnsemblBacteria" id="AAS12390">
        <property type="protein sequence ID" value="AAS12390"/>
        <property type="gene ID" value="TDE_1875"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1875"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1775"/>
    <dbReference type="eggNOG" id="ENOG5030TAS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_756347_0_0_12"/>
    <dbReference type="OrthoDB" id="1650691at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="366" mass="41674" checksum="6565AE7AA607C2AB" modified="2004-07-05" version="1">MFFYRVQDKVSMTMSFFVMAACIIGIVLVLFFASTKLRKINAVLAIVLSTALSCILMIPLMTAFNSFVNKKVVNEVTDSQLAEIEARKAQIKLLAANQELKEKEKEILDNKINMQKQSIEISGLEDSLRVLQNTQLNMQSFKEILELGLLEANLKQTNLYRKQLSGISTGMGLKADQYYDEGLVILTHDIDAKFGVDLKKIKITVSKDFPNILWIKDIQPKFLGASKNKHIKEVAEIRRVDIKNNIKTYNILNGQSEVKKANQYADLCEQEYQTRLSQGLETNFMNDAVLKLAENFIKLILSPLKKEIRFDSGLDGDTMSLEEYIETELKEIQAKRLELEDSNKTLDAETQTKEKELENLKSKIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LK6</accession>
    <name>Q73LK6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972460.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669614.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1856"/>
    <dbReference type="EnsemblBacteria" id="AAS12371">
        <property type="protein sequence ID" value="AAS12371"/>
        <property type="gene ID" value="TDE_1856"/>
    </dbReference>
    <dbReference type="GeneID" id="2740045"/>
    <dbReference type="KEGG" id="tde:TDE_1856"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1761"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078147_2_1_12"/>
    <dbReference type="OMA" id="MDIKAPL"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012840">
        <property type="entry name" value="NrdG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01094">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02495">
        <property type="entry name" value="NrdG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="12"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="247" mass="27357" checksum="C18DD0A15AE67943" modified="2004-07-05" version="1">MLAGLQKTTLVNFPRRVAAAVFLPGCNIRCPYCHNAELALASPSSFTANQESSNDYYELSEIYTFLERRKNLISGLVISGGEPFMSPALFELIERAKSLNLAVKIDTNGLFPERIEEVLRSSNLQPDMIAIDVKTSPERYGELLASKTDSAAKKAKTALLKTLDILKSNTEKTEVEYRTVLAPPLVSEDEIKKIASLLPKNARWRLAQFVPGTCLNPEWNSVEPYPLSQAQALTAIAKSLIPDTELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LM7</accession>
    <name>Q73LM7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1779</name>
        <name evidence="3" type="ordered locus">TDE_1835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405</strain>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972383.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972439.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679540.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1779"/>
    <dbReference type="EnsemblBacteria" id="AAS12294">
        <property type="protein sequence ID" value="AAS12294"/>
        <property type="gene ID" value="TDE_1779"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12350">
        <property type="protein sequence ID" value="AAS12350"/>
        <property type="gene ID" value="TDE_1835"/>
    </dbReference>
    <dbReference type="GeneID" id="2741223"/>
    <dbReference type="KEGG" id="tde:TDE_1779"/>
    <dbReference type="KEGG" id="tde:TDE_1835"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1695"/>
    <dbReference type="HOGENOM" id="CLU_579923_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="471" mass="56033" checksum="11F93296E7C8CA26" modified="2004-07-05" version="1">MEEKKHKELKLSIDINTDVEKILSKKDKEIIIDQIILHFDSGKLQEVLKLSYYLLSKDQTYYFSSMKRKGFFRIGTKEFNTKKISYIIENILSKTHEQLKIENVNYLRSMLALHYVAPECRNILKFADNVIKKYKKRFIKTLYAILEFDLLEVKIGKPSYSNLISDPIYGVDPVSEAISTLVDRYTKEFNVSDEDFGPLDINSHKNIISDCKKLLQKIIVVNKIQKFEYEVETYGYNFEQRNDKICYMISKEKIEKAKVLTYFVTPSHHYNAIIKELLSRKDNISIYELFEKNISSTEYWKIEELPTRRIVIFLLFNENIKIFDSDNLFREEFAFLSELLTEFHIDDNNIKDMKLKNGIGVFDVIKFKRIIEFCAYAINYALNKHNNDCFLQYESIVPVYSYDLFINMLNKIYKDTEIINKLINELTWDKKINLISKRHLFLWGELLFYLVLTIWKAVIFLEIYALKIMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LQ8</accession>
    <name>Q73LQ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972408.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957055.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1804"/>
    <dbReference type="EnsemblBacteria" id="AAS12319">
        <property type="protein sequence ID" value="AAS12319"/>
        <property type="gene ID" value="TDE_1804"/>
    </dbReference>
    <dbReference type="GeneID" id="2739234"/>
    <dbReference type="KEGG" id="tde:TDE_1804"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1716"/>
    <dbReference type="eggNOG" id="ENOG5030V3J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_336137_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="848" mass="101824" checksum="227DA200E64FDED7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LQ9</accession>
    <name>Q73LQ9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972407.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957054.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1803"/>
    <dbReference type="EnsemblBacteria" id="AAS12318">
        <property type="protein sequence ID" value="AAS12318"/>
        <property type="gene ID" value="TDE_1803"/>
    </dbReference>
    <dbReference type="GeneID" id="2739233"/>
    <dbReference type="KEGG" id="tde:TDE_1803"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1715"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075305_2_0_12"/>
    <dbReference type="OrthoDB" id="1985370at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="291" mass="33496" checksum="7E10E36C4E288E71" modified="2004-07-05" version="1">MENYENRIVAFIDILGFKDLIKKSENNPYQINELLEILKYIKAWDTQGQNKWDTNVIAVEEDAQTKGLEKFDISGITACTCFSDSIVVSVQCENELINEKASTLIGNLSKIGAKLLQAGILIRGAMTVGNLIHTNDGIIMGPAIIEAYLLESNYAKNPRIILSDKLIGKLNYPLKRKSDRYPYHQYINRFKDGCAGFHQMQFFQVMQSEVNEQNKLKYDLDVIRKRLIDGLDMSFSKPEVFLKYQWLMNQYNELVINEDNVKKPIYDVNLADSHLNIHYSPIDQVRNKEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LU8</accession>
    <name>Q73LU8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972368.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669498.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1764"/>
    <dbReference type="EnsemblBacteria" id="AAS12279">
        <property type="protein sequence ID" value="AAS12279"/>
        <property type="gene ID" value="TDE_1764"/>
    </dbReference>
    <dbReference type="GeneID" id="2740609"/>
    <dbReference type="KEGG" id="tde:TDE_1764"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1686"/>
    <dbReference type="eggNOG" id="ENOG5031VMC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2083840_0_0_12"/>
    <dbReference type="OrthoDB" id="2134721at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="117" mass="14184" checksum="E52640218E6D0DF1" modified="2004-07-05" version="1">MFSFLIIKNQISEKIALKIEFTKYKKELDRYIADNTKNENIRIFDNYVGIIWDPGFLDNYSVIIYDKNNNLDILYNSSGDIFENKEIYNEFKKAFEYEKIVDIIKIEDNYFRCNIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LX4</accession>
    <name>Q73LX4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M23/M37 peptidase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972342.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679456.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1738"/>
    <dbReference type="EnsemblBacteria" id="AAS12253">
        <property type="protein sequence ID" value="AAS12253"/>
        <property type="gene ID" value="TDE_1738"/>
    </dbReference>
    <dbReference type="GeneID" id="2739196"/>
    <dbReference type="KEGG" id="tde:TDE_1738"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1661"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_7_2_12"/>
    <dbReference type="OMA" id="YEFYFFD"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284936" evidence="1">
        <location>
            <begin position="21"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="201"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="303" mass="33787" checksum="B21E53E54DC94F23" modified="2004-07-05" version="1">MKAFKFLFLFFFLSGSILKAQVPYPQIEKLHIDDYIFVQYCDDVADARKALALAKTGNELPIRFYTYKANSEDTIIKIAARCSIPYDAIVTLNRIESVQTDIAGRVLILPTMPAVYLPEKALSSIEKLTEALFRKNKTEPLKIKIYGPEEKREIFCFPGEIFDGTVRAFFFMPFYRFPLKDAVITSSFGKRQDPFTGKASYHPGIDIAAPTGSPVMACAAGRVKEISYNKVYGNYIILTHTDGRASLYGHLSKVYASLNETIKSGTIIGAVGSTGMSTGPHLHFEIHEQGIPKNPANFVNTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LX9</accession>
    <name>Q73LX9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ordered locus">TDE_1733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972337.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670900.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1733"/>
    <dbReference type="EnsemblBacteria" id="AAS12248">
        <property type="protein sequence ID" value="AAS12248"/>
        <property type="gene ID" value="TDE_1733"/>
    </dbReference>
    <dbReference type="GeneID" id="2739191"/>
    <dbReference type="KEGG" id="tde:TDE_1733"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1657"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_12"/>
    <dbReference type="OMA" id="GDHAYTF"/>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="12"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="248" mass="27004" checksum="EF807BFC0E6B5521" modified="2004-07-05" version="1">MIIIKTEEQINGIRKSCKALAQLFEELKPVIKPGISTKELDDFCVNYIKKIGGVPAWYSEGFPGAACISINEEVIHGIPGKRIVKDGDLVSMDIGIDLGGYISDSCVTYPVGNVSKENLKLLEVTTRCLYAGIEACKAGKRVSDISKAVFNLASAHNYGVVYDYCGHGVGLGVHEDPSIPNVPERMRPNPRLRAGMVVAIEPMINMGTADVEVKKDGWTVVTADRSVSCHMEHTVAIFEDHTEILSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M13</accession>
    <name>Q73M13_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972302.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669381.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1698"/>
    <dbReference type="EnsemblBacteria" id="AAS12213">
        <property type="protein sequence ID" value="AAS12213"/>
        <property type="gene ID" value="TDE_1698"/>
    </dbReference>
    <dbReference type="GeneID" id="2740870"/>
    <dbReference type="KEGG" id="tde:TDE_1698"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1624"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069826_0_0_12"/>
    <dbReference type="OMA" id="WVELSID"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="58"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="282" mass="32720" checksum="6DA66A7D8C24204D" modified="2004-07-05" version="1">MIKKRKLLVYIIFVCLVLISCGHGLSEFLYRPNSVSDRSTKIVDLAAPHTLPASKKFTCVIFTDIHFGADRRRYDKEFIDWLKNKKASNEFPSFIISMGDIVEHGKEEEYKQYVSFVADIKKIQDVPVYTALGNHDLHNSGWLHWKKYIYPHVPYYRFKTNKFSWYVIDAGDGMLGEPQLRNMVEEMKADPNPKFVFSHYAIYGGGIPYFVMLNTKERAVLIDTFSRNNVKVFFAGHYHPGMLIYSYGTFSELVVRSILKSPSWVELSIDETNSSFSVKEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M30</accession>
    <name>Q73M30_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">V-type ATPase, D subunit</fullName>
            <ecNumber evidence="5">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">atpD</name>
        <name evidence="5" type="ordered locus">TDE_1681</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972285.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679385.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1681"/>
    <dbReference type="EnsemblBacteria" id="AAS12196">
        <property type="protein sequence ID" value="AAS12196"/>
        <property type="gene ID" value="TDE_1681"/>
    </dbReference>
    <dbReference type="GeneID" id="2740136"/>
    <dbReference type="KEGG" id="tde:TDE_1681"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1608"/>
    <dbReference type="eggNOG" id="COG1394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113661_0_0_12"/>
    <dbReference type="OMA" id="VQIPGYK"/>
    <dbReference type="OrthoDB" id="1204844at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="204" mass="23638" checksum="50E98206C4E7628A" modified="2004-07-05" version="1">MAIKLTKNELKNQKESLKMYRRYLPTLQLKKQQLQTEIRTIEARAKEVRLHRDALHREFEDWVAVFGEQNVFHPSMVKIKELLTSTGNIAGVSIPVFSGAEFERSKYDLYKTPLWVDTAAEKLQEVLSLDLEAKVLDEQVRLLNSELRTTTQRVNLFEKVKIPETRANIKKITVYLGDQQVAAVVRGKISKKNLEKVHHKDEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M59</accession>
    <name>Q73M59_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972256.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679334.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1650"/>
    <dbReference type="EnsemblBacteria" id="AAS12167">
        <property type="protein sequence ID" value="AAS12167"/>
        <property type="gene ID" value="TDE_1650"/>
    </dbReference>
    <dbReference type="GeneID" id="2738991"/>
    <dbReference type="KEGG" id="tde:TDE_1650"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1576"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_12"/>
    <dbReference type="OMA" id="ELFPYLM"/>
    <dbReference type="OrthoDB" id="1713578at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="246" mass="27710" checksum="9F248810E08E081B" modified="2004-07-05" version="1">MKAEIISLKNISKTFVQSSFDGTVNFKALDEISLSVFKGESILISGANGSGKTLLMSIIAGLIRPSSGLVDVKERCGIVFQDSDLQILGETPEEDIMFGLKNIKLPQEERKKRLETALEKTGLKDKRYYSSRSLSGGEKRRLCVAGILAMKFPVIIFDEPYANLDYEGVVQVNSLIKELKTENYTLLILSHELEKCYALADRFLVLHRGKKVFDGTAEEGLRQNLKEWSIRPPLTSYTKREDLIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M89</accession>
    <name>Q73M89_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_1620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972226.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679307.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1620"/>
    <dbReference type="EnsemblBacteria" id="AAS12137">
        <property type="protein sequence ID" value="AAS12137"/>
        <property type="gene ID" value="TDE_1620"/>
    </dbReference>
    <dbReference type="GeneID" id="2740861"/>
    <dbReference type="KEGG" id="tde:TDE_1620"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1548"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_8_1_12"/>
    <dbReference type="OMA" id="SYPHFIG"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="21"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="667" mass="76499" checksum="8E85A61319D8CD64" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MA6</accession>
    <name>Q73MA6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972209.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679287.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1603"/>
    <dbReference type="EnsemblBacteria" id="AAS12120">
        <property type="protein sequence ID" value="AAS12120"/>
        <property type="gene ID" value="TDE_1603"/>
    </dbReference>
    <dbReference type="GeneID" id="2740844"/>
    <dbReference type="KEGG" id="tde:TDE_1603"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1532"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_12"/>
    <dbReference type="OrthoDB" id="870493at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="261"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="293"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="481" mass="53842" checksum="4C0514B74E900207" modified="2004-07-05" version="1">MGIVEARIKNFTYENDESPTLHAIDLSIEEGELVVLTGFSGCGKTTLTRILNGLIPYHYGGILDGEVRILGKNILDYKKGELAKYIGNVFQNPSDQFFATIAEEEVAFAGENLGMDSQTLCEKTDAAFQTMQIESLKGAKLSELSGGQKQKVAIASTLIYDTKLLFFDEPSSNLDYEGIVQFQAMIRDLKAMGKTIIIAEHRLFFLNELYDKLIYMKDGTIEKIFLKGELTTEDCRRYGLRAIRYDSLVCENPSVPKQAVTHIEGLSVSIGRRELIKNLSFDVHAGEITAVIGKNGIGKTTLGKALGGLLSCKGQIGYGKRRRQRLRNAYYMMQDVDYQIFFDTVENELIPSSKRKDESYLQQAAEYLRTIDLWEKRLDHPQELSGGQKQRLALATAFLSGRRIIILDEPTSGLDYKRMDEIAKLILHCAQEVSVLIITHDLELLFKVCNTALLLGENAYKKIPVNGNEGEIIGFMGKLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ME2</accession>
    <name>Q73ME2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972172.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1566"/>
    <dbReference type="EnsemblBacteria" id="AAS12083">
        <property type="protein sequence ID" value="AAS12083"/>
        <property type="gene ID" value="TDE_1566"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1566"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1500"/>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_769329_0_0_12"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="360" mass="41656" checksum="13C4C5F277B465C8" modified="2004-07-05" version="1">MTHTDNQGDNEEQKAKRYYYHSDHLGSAQFVTDWKGRQYENIEYTPYGELWTYKSKTAMLFLTTYNNFLAKQPSGLIEEVAAGLDKLPFRFTGKELDEETGLYYYGARYLDPKYSRWLSGDPALNDYMAGSSVGKGGIYNTVNFNVYHYGGNNPIKYIDPTGMYTEDEIENFKKSSAKKQLEFLKNEYDSVKVSPSNQLRGEKSKEMRTLKDSMKLDGLFKADETFMNETLHDFLNLKEDGTMNYSLDELMNPNSGWSEVSSIESQYHQTNAEKPNLNAKFIHQDGREVVINSKEMVVLDYPDKGTFNYVNGSIINPLTWRGHSLYDIKPYEKLITHNVLITSNKSYWFGYNTSCWIKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MM4</accession>
    <name>Q73MM4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972090.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679151.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1484"/>
    <dbReference type="EnsemblBacteria" id="AAS12001">
        <property type="protein sequence ID" value="AAS12001"/>
        <property type="gene ID" value="TDE_1484"/>
    </dbReference>
    <dbReference type="GeneID" id="2739885"/>
    <dbReference type="KEGG" id="tde:TDE_1484"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1423"/>
    <dbReference type="eggNOG" id="ENOG50301UA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1610048_0_0_12"/>
    <dbReference type="OMA" id="FMQSADI"/>
    <dbReference type="OrthoDB" id="1956981at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284610" evidence="1">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="169" mass="18811" checksum="BD885D30F1BCF738" modified="2004-07-05" version="1">MKKIFFLSICLFLSVLTFIHAEQENRDVTGLALEYGLIGRQSDFGISLAITSPWLFHNAFALHLNADCFFPNSQRRTPYYVLDFSVLGGSLMQTANIRVYGGGGPIVIFPVQKNKPKVLVTGQGFFGFEFFMGKSPAGLSFFIEMGGGGFGFTAKTGLRYTFPMLYREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MT0</accession>
    <name>Q73MT0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase, group 1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972033.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679045.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1427"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11944">
        <property type="protein sequence ID" value="AAS11944"/>
        <property type="gene ID" value="TDE_1427"/>
    </dbReference>
    <dbReference type="GeneID" id="2739704"/>
    <dbReference type="KEGG" id="tde:TDE_1427"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1368"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_0_12"/>
    <dbReference type="OMA" id="INMNIGG"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="3">
        <location>
            <begin position="17"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="207"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="465" mass="53145" checksum="017AF325ADE889CA" modified="2004-07-05" version="1">MEKLKLLFITYTHSNGGGAEKVLTTLVNNLDAERYDISIFEIVKYDVKCEPVNSNIKLLPPLYHCNDRDYKIKVLDYILEQKPEIIRALNNFDAYDVIITWNYQLPSFMLPAFPEKKTIAWFHGAIDDLDISDNSTAVKSRYNLQKNAWGFADKVVTISHKSLQSLETVFPEYMHKAQIIYNAFDVKNSKIKATERVEDIYENCYLPIIVCAGRLDKNKNFSLLVKTVAKLKTDNIKCALFIIGDGEEREPLVRLVAESGITDSVFFLGYKQNPLPYISRAQLLCVSSLAEGFPTVVLESMALGKPFVTTPVAGASEELADGGKCGLVADWNVDDYAEMVKMLLTDKTLYDRMSENCIKKIQEFSIENTVKQFDILIASLPEKKDIQISCLSKQEAFKKVKAVYVWHPDEIIKRIKFSITRFASRKTLYHFMLLGYHILNLFRYILCTPIRICTAKKVLLRKDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MU7</accession>
    <name>Q73MU7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972016.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679004.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1410"/>
    <dbReference type="EnsemblBacteria" id="AAS11927">
        <property type="protein sequence ID" value="AAS11927"/>
        <property type="gene ID" value="TDE_1410"/>
    </dbReference>
    <dbReference type="GeneID" id="2741277"/>
    <dbReference type="KEGG" id="tde:TDE_1410"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1352"/>
    <dbReference type="eggNOG" id="ENOG502ZJ9G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092314_0_0_12"/>
    <dbReference type="OMA" id="MINTYSE"/>
    <dbReference type="OrthoDB" id="1789644at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="221" mass="25296" checksum="C3726AF90A5F94C9" modified="2004-07-05" version="1">MINTYNESDLHKSLKEHFCPKNGKKEQPLLGSICDILCDGGQVIEIQTSNLSALRVKLEKFLPSHKVLIIYPIAVDAYIQIINQDGSTRHRRKSPKHGSFFQIFRELSGLYHLIDNKNLSFKLVYINCEVIKADTGPKKRRAYRPGVINKKLIEIHSTEDHKNMKAICKKVLDLLPEEFTNQDIKNIGAKSYASYTSWFLSKAGLTSSEGKRGRFKLYKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MW7</accession>
    <name>Q73MW7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971995.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678973.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1389"/>
    <dbReference type="EnsemblBacteria" id="AAS11906">
        <property type="protein sequence ID" value="AAS11906"/>
        <property type="gene ID" value="TDE_1389"/>
    </dbReference>
    <dbReference type="GeneID" id="2741256"/>
    <dbReference type="KEGG" id="tde:TDE_1389"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1331"/>
    <dbReference type="eggNOG" id="ENOG5030SE6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_562496_0_0_12"/>
    <dbReference type="OMA" id="QENIRYM"/>
    <dbReference type="OrthoDB" id="497366at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="485" mass="55971" checksum="69436BA4169596D6" modified="2004-07-05" version="1">MNQPKKYIFCFDIIAGFLLIFSFFLLIFVPMSSMSTLWKDYRVLFLPMEVDEPAILQAAEEHGITGIISSQTIENRFSDLEEQGYTGYPFTDKERYTQWFINDQENIRYMYIPSDKHITKDFFRFLKKNTGYFFIENDTSFSAFQFFIALIFFAVSFFYTSRKKNYFSAAFPFVIYAAFQRGILALSSSILIMYTLAFWMEAIGSSLKFTREQLVSRIKKNPLLVFFPFVALIIAKFNSNISLVLFVFAISASASFTYIIERFSFFVEEKMDTQKIHKTIRAYVMNPQSIAKFWHTRHLFAVSSCALFSIAFSALFLYFSFNKTIKAYQNTLYLPMPEASVGIPGFSKKAFDELKKIRTGDDLPDLGNLISDTWNAKVIPFTRLGLSPQENDRVSFNDFSVDENGVVTEQDGLVFNFDDEFIKSVISFRTSPSIEDLLYSQGRFITASYAPKKFPLNRYNSAALLVALVSAIMPLMIILLRVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MY5</accession>
    <name>Q73MY5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNB-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971977.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678953.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1371"/>
    <dbReference type="EnsemblBacteria" id="AAS11888">
        <property type="protein sequence ID" value="AAS11888"/>
        <property type="gene ID" value="TDE_1371"/>
    </dbReference>
    <dbReference type="GeneID" id="2741132"/>
    <dbReference type="KEGG" id="tde:TDE_1371"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1317"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015903_2_0_12"/>
    <dbReference type="OMA" id="YWCLRWL"/>
    <dbReference type="OrthoDB" id="1602988at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="243"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="623" mass="70504" checksum="4DB991A5FDBF7456" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MZ3</accession>
    <name>Q73MZ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971969.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1363"/>
    <dbReference type="EnsemblBacteria" id="AAS11880">
        <property type="protein sequence ID" value="AAS11880"/>
        <property type="gene ID" value="TDE_1363"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1363"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1309"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_1_12"/>
    <dbReference type="OMA" id="GWTDRDE"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="169" mass="19009" checksum="1C89612FDEE03E4B" modified="2004-07-05" version="1">MKKRQSCRSFDYSKPVSKEDLISILEAGRLSPSACNSQPYEVFVAQGEKAKIIADAKMGSFNKFIDDCNTFLVIAEDNYSLPAKIGSLIKKVDFKAIDIGILTANLVNAASALNLETCILGVFDEKRIQKLIERKKRIRLVIALGYPKEGYPLREKTRKDFDDNMHFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NJ3</accession>
    <name>Q73NJ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971767.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010699135.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1159"/>
    <dbReference type="EnsemblBacteria" id="AAS11648">
        <property type="protein sequence ID" value="AAS11648"/>
        <property type="gene ID" value="TDE_1159"/>
    </dbReference>
    <dbReference type="GeneID" id="2741491"/>
    <dbReference type="KEGG" id="tde:TDE_1159"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1118"/>
    <dbReference type="HOGENOM" id="CLU_1937197_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="130" mass="15390" checksum="77CF52D7B8CC28F5" modified="2004-07-05" version="1">MIFFESLGLVEFFIEIEKYYGEYEENIRIVVFSFIKKLNDWERAALYNELIEHYSRGFSPPDVYRFNLHLKKAKEAAKRLKPSMVLSKKEENKEDIQKNLAEAAKEYGLDPNGKDLLKKMFACEIKKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NM9</accession>
    <name>Q73NM9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sigma factor regulatory protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971731.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682419.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1123"/>
    <dbReference type="EnsemblBacteria" id="AAS11612">
        <property type="protein sequence ID" value="AAS11612"/>
        <property type="gene ID" value="TDE_1123"/>
    </dbReference>
    <dbReference type="GeneID" id="2739539"/>
    <dbReference type="KEGG" id="tde:TDE_1123"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1083"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_6_12"/>
    <dbReference type="OMA" id="NAAHHPL"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="344"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="561" mass="62633" checksum="9A4552F7E58D84AC" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NU7</accession>
    <name>Q73NU7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971663.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682366.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11544">
        <property type="protein sequence ID" value="AAS11544"/>
        <property type="gene ID" value="TDE_1055"/>
    </dbReference>
    <dbReference type="GeneID" id="2740816"/>
    <dbReference type="KEGG" id="tde:TDE_1055"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1015"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_12"/>
    <dbReference type="OMA" id="AAWFELF"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="449" mass="49274" checksum="8839D7160A673BB4" modified="2004-07-05" version="1">MYKKDLDLTEGVIWKTLIIFTLPILAGNFFQHLYTAADAVIVGKFTGKEGLAAIDSVLSLLKLPINLFSGLSAGATIIISQLFGAKKIKELFTAIHTSIGLTLIAGISLSIIGVLISPLLLFMMGVPQDIFEMTLSYVRIYFAGMGISLFYNIGSGILRAMGNSKTPFYALIVSSILNVILDLIFIGIFKWGIGGAALATVLSQLISAVIILFALTKKTGYCPLLLSKIKIDRLSSIKIARLGLPIGIQSAFFPIANMIIQATVNGTGTDNIAACALCGKLDFLIWILLEAMTTSVATFVAQNYGARKYDRITGVVRIGLIMSGIIIGSICVMLYFWNVPLGKLFINSKDYEVLIISEKLMHILAPFYTVFIFTEVFSAAIHATGETFKPMLITLLGVCASRIVWIFLFVPINPVIEMIVLAFPISWTLTSIIFTVYYFIYRKKLYQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NW8</accession>
    <name>Q73NW8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium and cobalt transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971642.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682345.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1034"/>
    <dbReference type="EnsemblBacteria" id="AAS11523">
        <property type="protein sequence ID" value="AAS11523"/>
        <property type="gene ID" value="TDE_1034"/>
    </dbReference>
    <dbReference type="GeneID" id="2741512"/>
    <dbReference type="KEGG" id="tde:TDE_1034"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.994"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_0_1_12"/>
    <dbReference type="OrthoDB" id="822653at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="310" mass="36443" checksum="9E89ECF307375817" modified="2004-07-05" version="1">MFVKLDAELTPIDPRTEKITGPVAGYIKFKELIELQGLLGLDPLFIEQCSDFSQQNTLGVWEDYSFGVINIVEMENIFKDRDTIGLYISKNLFLAIEIIDKDYSAQKAFEAALQQTIVRERNIPRILNRFFKELIKSHTGVYHRFRKKISELEMRVWEKIEEDSNFESELSNINNELLTLFSYYDQLEDFCQELAENENEIFTEEELTIINLLSKRVERYGANIRILREYSNQLRESYQAQLDLHLNKIMKIFTVVTTIFLPLTLVVGWYGMNFTHMPELSWKYGYITVIILSIAIVVLGLCWFKKKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NY8</accession>
    <name>Q73NY8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tex protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971621.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956863.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1012"/>
    <dbReference type="EnsemblBacteria" id="AAS11502">
        <property type="protein sequence ID" value="AAS11502"/>
        <property type="gene ID" value="TDE_1012"/>
    </dbReference>
    <dbReference type="GeneID" id="2740992"/>
    <dbReference type="KEGG" id="tde:TDE_1012"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.972"/>
    <dbReference type="eggNOG" id="COG2183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009833_0_2_12"/>
    <dbReference type="OMA" id="RWAWRTR"/>
    <dbReference type="OrthoDB" id="120764at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="645"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="817" mass="90275" checksum="702BAC14DFAEDBF7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P27</accession>
    <name>Q73P27_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ComF-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971582.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682284.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0972"/>
    <dbReference type="EnsemblBacteria" id="AAS11463">
        <property type="protein sequence ID" value="AAS11463"/>
        <property type="gene ID" value="TDE_0972"/>
    </dbReference>
    <dbReference type="GeneID" id="2740544"/>
    <dbReference type="KEGG" id="tde:TDE_0972"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.936"/>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054549_0_0_12"/>
    <dbReference type="OMA" id="LWPTRCA"/>
    <dbReference type="OrthoDB" id="1937725at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="284" mass="32468" checksum="CA2AABC4097CDD1F" modified="2004-07-05" version="1">MIKRIKLRALTYLRNIYARIICPQVCFFCGEETGTGIPLCSKCLQKEITEPVLFRLKNPEKFCSSCGKILISEKELCTDCRAKLREKENLRTEEREKSKKEDCAKPLSVQSDFLKKVYTIYPYKGRGGELLRLWKNQNMRGFAEIYASAIASFIEGMPELQNVPMVPVPPRPKKIKTKGWDQIEDLSLYLEQIYNLPILRCLKRMDGASQKSLSRERRASNLKGKIFLKRQKSFSKSEDLKTALPEKLIILDDVMTTGATLNFCAAALKEGGCKEVIGLCLFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P44</accession>
    <name>Q73P44_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LemA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971565.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682263.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0955"/>
    <dbReference type="EnsemblBacteria" id="AAS11446">
        <property type="protein sequence ID" value="AAS11446"/>
        <property type="gene ID" value="TDE_0955"/>
    </dbReference>
    <dbReference type="GeneID" id="2740763"/>
    <dbReference type="KEGG" id="tde:TDE_0955"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.919"/>
    <dbReference type="eggNOG" id="COG1704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056714_0_0_12"/>
    <dbReference type="OMA" id="VETQYQR"/>
    <dbReference type="OrthoDB" id="1573349at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="202" mass="22789" checksum="938079C3A708C1D7" modified="2004-07-05" version="1">MGKGLKIGLIIVAVVLVLAFSLYNFFVGTYNSIVKAEEGVKSAWSQVENVYQRRFDLIPNLVNTVKGYASHEAKVFTDIAEARSKAGGVMQVSDEVLNNPESFEKFQQAQSELGAALQRLLVITENYPELKANQNFMDLQTQLEGTENRIAVERKRYNEAVQSYNVYIRQFPRSIIANMNGFREKAYFKADDQASTAPKVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P61</accession>
    <name>Q73P61_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971548.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0938"/>
    <dbReference type="EnsemblBacteria" id="AAS11429">
        <property type="protein sequence ID" value="AAS11429"/>
        <property type="gene ID" value="TDE_0938"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0938"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.904"/>
    <dbReference type="eggNOG" id="COG0116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032119_3_1_12"/>
    <dbReference type="OMA" id="GFMYKAN"/>
    <dbReference type="OrthoDB" id="1772619at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="50"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="UPF0020" evidence="2">
        <location>
            <begin position="173"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="403" mass="46125" checksum="51286652255817FF" modified="2004-07-05" version="1">MLYCKTLMNDFIALCAVGAEPVLTRELKLLGFKPYNRLPGRVFFTSAEAEPLLAFFKANYFLRTADRVFMLINTAKAENFDDLFDLVFSIDWHNYFPRDARITIDKVRTYKSKLSSEHAVQSIVHKAVCDKLCKKWNMHSLPETGTRFMIRIYIENNNVYVCLDLSGEPLYRRGYRLSGGAAPMRETLAAVLIQLMQWKRKIPLHDAFCGSGTIPIEAAWYAYNIPPGIARHFAFENFICFEKEKIEAVLKEEKERAASEVRTDCLARITGSDISEEAVSLSKANAERACIIAGRELHAAGITHHIERPDFIQSDFSELEAPYDSGILLSNPPYGERLGSEEEAFELYKRMAEIPQHFPNWKLGFITSKKEFEKIFCKQNKDAVLKKHSLRGGNMETVLYIME</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P68</accession>
    <name>Q73P68_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971541.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682237.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0931"/>
    <dbReference type="EnsemblBacteria" id="AAS11422">
        <property type="protein sequence ID" value="AAS11422"/>
        <property type="gene ID" value="TDE_0931"/>
    </dbReference>
    <dbReference type="GeneID" id="2740396"/>
    <dbReference type="KEGG" id="tde:TDE_0931"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.899"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_0_12"/>
    <dbReference type="OMA" id="NSMAGQN"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="448" mass="48945" checksum="913EEBC1E811D898" modified="2004-07-05" version="1">MKNLTQGDELKQITLFSLPMLLGNIFQQLYNVVDSIVVGKSIGDHALAAVGISFPVWFIFISLVIGFTMACNILIAQFVGAKKEEEISKVIQTSILILFWAGLIATAIGFVFAPYILKIMNTPSDVFEEALIYLRLIFTGIIFLFIYNAFTAMLRGFGDSMTPLYALIISTIINIGLDCLFVIVFKWGIAGAAIATIIAQFISCFWLIFYCRIKYKDFRVNFFKLKFDKTICIQSVKMGFPSGIQQALVGGGFMALLSIVNTFGTQTAAAYSAAGKLDGFIVMPALNIGVALSSFTGQNIGAGRLDRVKKGLRASLFLGLGITITATTAIVIFGKAVMFLFVNNPEVIELGARYLIIVAPAYFFNTITFTLNGVIRGAGETVFPMISTLLAMWVFRVPAAAVLSRYLGSDGIWLAVSVGSAAGFLLTLFYYCSGKWKKKTAEILNLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P98</accession>
    <name>Q73P98_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971511.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682186.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0901"/>
    <dbReference type="EnsemblBacteria" id="AAS11392">
        <property type="protein sequence ID" value="AAS11392"/>
        <property type="gene ID" value="TDE_0901"/>
    </dbReference>
    <dbReference type="GeneID" id="2739941"/>
    <dbReference type="KEGG" id="tde:TDE_0901"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.872"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123330_1_1_12"/>
    <dbReference type="OrthoDB" id="1598286at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="151" mass="17820" checksum="F7C2C0ABAE8374F9" modified="2004-07-05" version="1">MCLICKRIEMIKNGNNPYYVKELETGYVVIGDHQHFKGYTLFLCKEHKTEIFQLENDFKMKFLEEMSIIAEAVYKAFHAEKMNYELLGNGDTHLHWHLFPRINGDLEGHGLHGKGPVWWYPIDKMYDAANRPTSEELYDMKVKLLEHLKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PB1</accession>
    <name>Q73PB1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971498.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670228.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0888"/>
    <dbReference type="EnsemblBacteria" id="AAS11379">
        <property type="protein sequence ID" value="AAS11379"/>
        <property type="gene ID" value="TDE_0888"/>
    </dbReference>
    <dbReference type="GeneID" id="2739762"/>
    <dbReference type="KEGG" id="tde:TDE_0888"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.858"/>
    <dbReference type="eggNOG" id="ENOG5033HRK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168243_3_1_12"/>
    <dbReference type="OrthoDB" id="2041837at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045944">
        <property type="entry name" value="DUF6364"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19891">
        <property type="entry name" value="DUF6364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="80" mass="9375" checksum="65C18EEFF43008C2" modified="2004-07-05" version="1">MSKKLTLSIDNELIDFAHLYSLKSGISISRLFEQYLMNLRNADKQHKLNPKTAALYGIFEKRPIPDKKELRKEFYEKGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PB9</accession>
    <name>Q73PB9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cobT</name>
        <name evidence="10" type="ordered locus">TDE_0880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CobT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="4"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971490.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956831.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0880"/>
    <dbReference type="EnsemblBacteria" id="AAS11371">
        <property type="protein sequence ID" value="AAS11371"/>
        <property type="gene ID" value="TDE_0880"/>
    </dbReference>
    <dbReference type="GeneID" id="2740927"/>
    <dbReference type="KEGG" id="tde:TDE_0880"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.850"/>
    <dbReference type="eggNOG" id="COG2038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002982_0_0_12"/>
    <dbReference type="OMA" id="AWMRKCA"/>
    <dbReference type="OrthoDB" id="1765140at2"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="360" mass="38659" checksum="33EB97B82F2A8DE1" modified="2004-07-05" version="1">MSILENTLNSIKPVSEEEGKKAKLFWDSLAHPPGSLGALEEMTVRLAKIKGFDNLKIDKKITAVFCADNGVYAEKITSQPQITTFLLAEIMHTGKTGLGTISKWAESGIRVYDVGMIKTSERKNVINKKIKFGTENIAQGPAMSRKDCIRMIETGIEAAFEIADEGFDIAGIGELGICNTTTTAAVLSGLCGVEPELTVGRGASTTEAMYELKIKIVKKAIEINAPKKGDSIDCISKVGGFDIAAMCGCYIGLAARGIPAVIDGYISSLAALCAVNLNPLVRDYLFASHKSEERGAKICTAELGIEPVLSMKMRLGEGSGCPLLFKMLEGAVFTMQNMGKFTETMIDGADLVDIRKEQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PD1</accession>
    <name>Q73PD1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, FAD/FMN-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971478.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682144.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0868"/>
    <dbReference type="EnsemblBacteria" id="AAS11359">
        <property type="protein sequence ID" value="AAS11359"/>
        <property type="gene ID" value="TDE_0868"/>
    </dbReference>
    <dbReference type="GeneID" id="2740915"/>
    <dbReference type="KEGG" id="tde:TDE_0868"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.838"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_3_12"/>
    <dbReference type="OMA" id="NQRRDQY"/>
    <dbReference type="OrthoDB" id="1033671at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="4"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="335" mass="36296" checksum="35D6BE80A3649C34" modified="2004-07-05" version="1">MSLLFSSFKIKNIELNTKLVMPPMASEKADAGGIVSQALCDYYDEKTKGSYIGLVIIEHSYVSPQGKASAGQLSISDDSTIEGFKKLASVLHKNGAKVIAQISHAGAAARHKITGYDVLSSSSVMIPRKAPDYELPRAMTQEDIDKVINDFVQAARRAKEAGLDGVEIHSAHGYLLNQFFSPIMNKRTDKYNGSSIEGRTRLHIEIIEAIRKMTGLDFLIAVRLGACDYISGGSSLEDSVEACLLFKKAGVDLLDISGGFCGYTNPELEEEGWFSRITQAVKEKVGAPVILTGGIVSPEAAEKILQEEKADLIGVGRALLNDSDWPKKAKQKLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PG9</accession>
    <name>Q73PG9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971440.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0830"/>
    <dbReference type="EnsemblBacteria" id="AAS11321">
        <property type="protein sequence ID" value="AAS11321"/>
        <property type="gene ID" value="TDE_0830"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0830"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.799"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071023_5_0_12"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="138" mass="16003" checksum="7BE740B9E55D42B8" modified="2004-07-05" version="1">MICTFDAIGKNRSVYTFENTCVEDKNISLHDGTKKVIINAEAFNDTKNKELKEFLEYLKTGKAKSKFTRRIDAMIQTIKNNEQARQEYRLMSTFEMDAMDRGAYKTKRETAILMKQRGYPTSEILLMTGLPKSEIEKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-08" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PK2</accession>
    <name>ACYP_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>Acylphosphatase</fullName>
            <ecNumber>3.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Acylphosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">acyP</name>
        <name type="ordered locus">TDE_0797</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971407.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672192.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PK2"/>
    <dbReference type="SMR" id="Q73PK2"/>
    <dbReference type="STRING" id="243275.TDE_0797"/>
    <dbReference type="EnsemblBacteria" id="AAS11288">
        <property type="protein sequence ID" value="AAS11288"/>
        <property type="gene ID" value="TDE_0797"/>
    </dbReference>
    <dbReference type="GeneID" id="2740675"/>
    <dbReference type="KEGG" id="tde:TDE_0797"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.770"/>
    <dbReference type="eggNOG" id="COG1254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_2_1_12"/>
    <dbReference type="OMA" id="RESHFDI"/>
    <dbReference type="OrthoDB" id="2034659at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000326838" description="Acylphosphatase">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Acylphosphatase-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="94" mass="10812" checksum="6287C9D898BB0834" modified="2004-07-05" version="1">MDKETLRALHVIVKGRVQGVGFRYWTRSLAKSLNVKGRVRNLADYSVEIIAEADTDTLGEFVYALKHEHPYARVESLNSEEVRARGYTDFRIEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PM4</accession>
    <name>RL29_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmC</name>
        <name type="ordered locus">TDE_0775</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971385.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670007.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PM4"/>
    <dbReference type="SMR" id="Q73PM4"/>
    <dbReference type="STRING" id="243275.TDE_0775"/>
    <dbReference type="EnsemblBacteria" id="AAS11266">
        <property type="protein sequence ID" value="AAS11266"/>
        <property type="gene ID" value="TDE_0775"/>
    </dbReference>
    <dbReference type="GeneID" id="2740653"/>
    <dbReference type="KEGG" id="tde:TDE_0775"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.748"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_5_0_12"/>
    <dbReference type="OMA" id="YMDLRFK"/>
    <dbReference type="OrthoDB" id="2063644at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000130486" description="50S ribosomal protein L29">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <sequence length="69" mass="8235" checksum="73D5097500125744" modified="2004-07-05" version="1">MKNKSKYREMSYKELVSKRNDLKQKYMDLRFQAVVGHLDNPLEKRSMRREIAMLNTFIRQKELAGEGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PN7</accession>
    <name>Q73PN7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971371.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0760"/>
    <dbReference type="EnsemblBacteria" id="AAS11252">
        <property type="protein sequence ID" value="AAS11252"/>
        <property type="gene ID" value="TDE_0760"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0760"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.734"/>
    <dbReference type="eggNOG" id="ENOG5033AUW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1359911_0_0_12"/>
    <dbReference type="OrthoDB" id="2032217at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025748">
        <property type="entry name" value="PrcB_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14343">
        <property type="entry name" value="PrcB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PrcB_C" evidence="2">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="165" mass="17648" checksum="03983FDC00C46F2D" modified="2004-07-05" version="1">MPDDKVPTVPDKGADGSPGSSFKNPEILSSQPSESMQAVYEILIQGNNLKTGLPSIVKSQEDLQTLYSVLYGNSLKAPLIDFSKKAVVIAAAGPFNTGGYSIVPVSAIKTGKIINLVFEVKSPGPKDMVTQAFTRPYVIVSVDAEPDTEIFIEINGDAKNDKLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PP5</accession>
    <name>Q73PP5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971363.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682014.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0752"/>
    <dbReference type="EnsemblBacteria" id="AAS11244">
        <property type="protein sequence ID" value="AAS11244"/>
        <property type="gene ID" value="TDE_0752"/>
    </dbReference>
    <dbReference type="GeneID" id="2739871"/>
    <dbReference type="KEGG" id="tde:TDE_0752"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.727"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466864_0_0_12"/>
    <dbReference type="OMA" id="LISIHYH"/>
    <dbReference type="OrthoDB" id="1226564at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284995" evidence="1">
        <location>
            <begin position="20"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="609" mass="68336" checksum="B549D635287EEE07" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PT9</accession>
    <name>Q73PT9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971319.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0707"/>
    <dbReference type="EnsemblBacteria" id="AAS11200">
        <property type="protein sequence ID" value="AAS11200"/>
        <property type="gene ID" value="TDE_0707"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0707"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.685"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371281_0_0_12"/>
    <dbReference type="OMA" id="IAWILMG"/>
    <dbReference type="OrthoDB" id="907010at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="771" mass="86388" checksum="2832084529650401" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PU9</accession>
    <name>Q73PU9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971309.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956796.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0697"/>
    <dbReference type="EnsemblBacteria" id="AAS11190">
        <property type="protein sequence ID" value="AAS11190"/>
        <property type="gene ID" value="TDE_0697"/>
    </dbReference>
    <dbReference type="GeneID" id="2739819"/>
    <dbReference type="KEGG" id="tde:TDE_0697"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.676"/>
    <dbReference type="eggNOG" id="ENOG5030XRK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_212166_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="50" mass="5660" checksum="20BFF7E6F246EC30" modified="2004-07-05" version="1">MPRNIDHFNKFENNGITVYVKKGTPSVNGTLTITVGAFLWFEKLMVEGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PW3</accession>
    <name>Q73PW3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sec translocon accessory complex subunit YajC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">yajC</name>
        <name evidence="10" type="ordered locus">TDE_0682</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971295.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672297.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0682"/>
    <dbReference type="EnsemblBacteria" id="AAS11176">
        <property type="protein sequence ID" value="AAS11176"/>
        <property type="gene ID" value="TDE_0682"/>
    </dbReference>
    <dbReference type="GeneID" id="2740241"/>
    <dbReference type="KEGG" id="tde:TDE_0682"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.663"/>
    <dbReference type="eggNOG" id="COG1862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116157_1_1_12"/>
    <dbReference type="OMA" id="CRIPMQK"/>
    <dbReference type="OrthoDB" id="1673470at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS11176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="137" mass="15046" checksum="DA576F05253F0529" modified="2004-07-05" version="1">MNFMPLLQGTAPGGFGSFGFLIPMLLVFVIFYFLLIRPQKKEQQKTEKMISQLQKGDKIITIGGIHGVVSSTKEKTIIIKVDDNCKIEINRSAVGAVLKDEPPKPDFGGEGEKKKSLFGKKADDSANDDTVSQNESK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q17</accession>
    <name>GRPE_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">grpE</name>
        <name type="ordered locus">TDE_0627</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971241.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681814.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73Q17"/>
    <dbReference type="SMR" id="Q73Q17"/>
    <dbReference type="STRING" id="243275.TDE_0627"/>
    <dbReference type="EnsemblBacteria" id="AAS11122">
        <property type="protein sequence ID" value="AAS11122"/>
        <property type="gene ID" value="TDE_0627"/>
    </dbReference>
    <dbReference type="GeneID" id="2739352"/>
    <dbReference type="KEGG" id="tde:TDE_0627"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.605"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_5_2_12"/>
    <dbReference type="OMA" id="YAYEKIA"/>
    <dbReference type="OrthoDB" id="1906715at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000113886" description="Protein GrpE">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="247" mass="27948" checksum="3596D1C48C68E5B7" modified="2004-07-05" version="1">MKKNHEKHADKKEAAKEELEKDLQPKDESAVKDEQGAGCGCETSKENPQEDKAEQNSSTGGKCEKNDDVLSPEKRIEELEAKCRDWQDQYLRKAADFENYRKRMIREKQEAIDYANSNLLLDLVQVLDDFDRAIDAGKTQGGESVNNAFVEGVVMIKNQMVSMLSSKYGLSYYPAKGEAFDPNLHEAVSMIQSPDVKEAVVGEELQKGYKLKERVIRHSKVMVLMPAEKQDEKKAEESEAADKKNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q25</accession>
    <name>Q73Q25_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_0619</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971233.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956790.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0619"/>
    <dbReference type="EnsemblBacteria" id="AAS11114">
        <property type="protein sequence ID" value="AAS11114"/>
        <property type="gene ID" value="TDE_0619"/>
    </dbReference>
    <dbReference type="GeneID" id="2740464"/>
    <dbReference type="KEGG" id="tde:TDE_0619"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.597"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_12"/>
    <dbReference type="OMA" id="MQEVANY"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
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            <begin position="289"/>
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            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="410"/>
            <end position="639"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAS11114.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
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    </evidence>
    <sequence length="696" mass="75705" checksum="6A64F9270C9FF4E7" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="AAS11090.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="44" mass="5183" checksum="BB9AEF5D95B5F67C" modified="2004-07-05" version="1">MEDYNKEFKIDIPKKQPEYYISDNGAIEYVGSAKDGRWIVKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
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        <name evidence="2" type="ordered locus">TDE_0569</name>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
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                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11064.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="148" mass="16166" checksum="7E5854F0A8D232A7" modified="2004-07-05" version="1">MKGTNSSYNHSHQKTYKSEAKHLTRSSVPDTIFSNKQQATSNKQQATSNKQQATSNKQQSGINFRSAQTNSQLNTNFLTVNRTHKSKSPSLCVFYITHSIKPLRGSAPKNPTYKRGFQRGVPFGSAGTTSVASRSKEGVIGGEKTALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QA6</accession>
    <name>Q73QA6_TREDE</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ordered locus">TDE_0537</name>
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    <organism evidence="1 2">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AAS11032">
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    </dbReference>
    <dbReference type="GeneID" id="2741756"/>
    <dbReference type="KEGG" id="tde:TDE_0537"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.523"/>
    <dbReference type="eggNOG" id="ENOG502ZAIH">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071247_0_0_12"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="324" mass="36626" checksum="92D003BF2E6242BE" modified="2004-07-05" version="1">MNNLKLSLLKKWELDSELSFVHGSVLLPDGTAIILTKGEKSDWGKFYLLVLSVDGIKKIPIEYAETSGRDYPVLFRYGASFGLIISAKEVRYYSGIHSSPEIIPIKNNSRLRGSIVPEKAQQRCFQNISDSKTIPVCFENEFYCGDARYFALFEFDVAAKSAEWKCFSTIDKKAFTHQDDSCVDAPKIDSIKISDKEIYAFIPGDSQTSVNKWGMNYYALARISEDGKVIKKLIESDDLKKDGKKGGINGCFTDSQYVIMTPLFKTDDWKGKQKVFSLNTREYSDITFPRGMSKHKLENISGEICLTSFYDRGLKEIALCNINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QB1</accession>
    <name>Q73QB1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
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    </protein>
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        <name evidence="2" type="ordered locus">TDE_0532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QF4</accession>
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        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
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                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
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                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
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                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
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                <person name="Shatsman S."/>
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                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
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                <person name="Sodergren E."/>
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                <person name="Weinstock G.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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    </dbReference>
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            <end position="176"/>
        </location>
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        </location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="299" mass="33546" checksum="5A9DA3A559171224" modified="2004-07-05" version="1">MTDNVEKILNRFFFKNVNGIWTGNIGNNKFLIRQDKSTNQELVLKTSCAVSGAKGDLFAFLDEQKKMGKIKTFNMDEDLLSLTYTCNNNDSEFEFFLKDLSDILTKLESHDVCFSCNKIRETNAYKIKNVPTFLCSECVENFKTKMEKVNNEPNNYLTGALCCIIGALVGSLAWILIGYFGFYASIAGYFIAYSAFYGYNFGKGKATKTGAIINIIAIVFALLFAEYIGLFLAVQKEVSLDFVSFVKFSPVFFADPVFIKSILPSLGLGFLFAGLGSYRIIKDMFTKANELSDISIERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QH4</accession>
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        </submittedName>
    </protein>
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        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="RefSeq" id="WP_010956752.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0469"/>
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        <property type="protein sequence ID" value="AAS10964"/>
        <property type="gene ID" value="TDE_0469"/>
    </dbReference>
    <dbReference type="GeneID" id="2739223"/>
    <dbReference type="KEGG" id="tde:TDE_0469"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.454"/>
    <dbReference type="eggNOG" id="COG1033">
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    </dbReference>
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    <dbReference type="OMA" id="LHFVSHF"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MMPL_dom"/>
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        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="38"/>
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            <end position="245"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="252"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="836"/>
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        <location>
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            <end position="871"/>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="8">
        <location>
            <begin position="747"/>
            <end position="873"/>
        </location>
    </feature>
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        <location>
            <begin position="527"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10964.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="905" mass="101001" checksum="3ED4D5804D8D5F0C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QL4</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ordered locus">TDE_0429</name>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AAS10924">
        <property type="protein sequence ID" value="AAS10924"/>
        <property type="gene ID" value="TDE_0429"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0429"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.416"/>
    <dbReference type="HOGENOM" id="CLU_201993_0_0_12"/>
    <dbReference type="OrthoDB" id="2196268at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="72" mass="8493" checksum="50DAE2F3B4CE3EDA" modified="2004-07-05" version="1">MQSKNRFFIAIIFILILLYGCKTTDTSKKQNYSQAEYFNMAESTAKEKKTEQELYTIIQKPLKQTRLILKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QM1</accession>
    <name>Q73QM1_TREDE</name>
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        <submittedName>
            <fullName evidence="2">Bacteriocin-type signal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971036.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956740.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0422"/>
    <dbReference type="EnsemblBacteria" id="AAS10917">
        <property type="protein sequence ID" value="AAS10917"/>
        <property type="gene ID" value="TDE_0422"/>
    </dbReference>
    <dbReference type="GeneID" id="2739586"/>
    <dbReference type="KEGG" id="tde:TDE_0422"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.409"/>
    <dbReference type="HOGENOM" id="CLU_448282_0_0_12"/>
    <dbReference type="OrthoDB" id="2156795at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="614" mass="68577" checksum="F7CE75FE9CAC9CE0" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QN2</accession>
    <name>Q73QN2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate/guanylate cyclase catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971025.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681441.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0411"/>
    <dbReference type="EnsemblBacteria" id="AAS10906">
        <property type="protein sequence ID" value="AAS10906"/>
        <property type="gene ID" value="TDE_0411"/>
    </dbReference>
    <dbReference type="GeneID" id="2740157"/>
    <dbReference type="KEGG" id="tde:TDE_0411"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.398"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_85_1_12"/>
    <dbReference type="OMA" id="RFNYSAM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007890">
        <property type="entry name" value="CHASE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05226">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="439"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="694" mass="77345" checksum="CE3800905F68D1C0" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QT1</accession>
    <name>Q73QT1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Bacterial Ig-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970976.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681357.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73QT1"/>
    <dbReference type="STRING" id="243275.TDE_0362"/>
    <dbReference type="MEROPS" id="C66.002"/>
    <dbReference type="EnsemblBacteria" id="AAS10857">
        <property type="protein sequence ID" value="AAS10857"/>
        <property type="gene ID" value="TDE_0362"/>
    </dbReference>
    <dbReference type="GeneID" id="2741082"/>
    <dbReference type="KEGG" id="tde:TDE_0362"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.352"/>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018923_0_0_12"/>
    <dbReference type="OrthoDB" id="262652at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003343">
        <property type="entry name" value="Big_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015117">
        <property type="entry name" value="IdeS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008964">
        <property type="entry name" value="Invasin/intimin_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02368">
        <property type="entry name" value="Big_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09028">
        <property type="entry name" value="Mac-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00635">
        <property type="entry name" value="BID_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49373">
        <property type="entry name" value="SSF49373"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="BIG2" evidence="1">
        <location>
            <begin position="126"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="647" mass="73937" checksum="1D7E309DC304999C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QX5</accession>
    <name>Q73QX5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970932.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681277.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0318"/>
    <dbReference type="EnsemblBacteria" id="AAS10813">
        <property type="protein sequence ID" value="AAS10813"/>
        <property type="gene ID" value="TDE_0318"/>
    </dbReference>
    <dbReference type="GeneID" id="2740517"/>
    <dbReference type="KEGG" id="tde:TDE_0318"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.307"/>
    <dbReference type="HOGENOM" id="CLU_2248872_0_0_12"/>
    <dbReference type="OrthoDB" id="2209403at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="104" mass="11868" checksum="9CFB12A57DA44D3F" modified="2004-07-05" version="1">MENEKLEILNMIRDKAITPEEGLKLLEAIQKENVKFVFEEPKQKKDSETIVISTKIPSKSDPADFLEKAADSENTVNETFENKKKKNIDITIQTPDGKTQSFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QY9</accession>
    <name>Q73QY9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970918.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0304"/>
    <dbReference type="EnsemblBacteria" id="AAS10799">
        <property type="protein sequence ID" value="AAS10799"/>
        <property type="gene ID" value="TDE_0304"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0304"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.292"/>
    <dbReference type="eggNOG" id="ENOG5033RIG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457028_0_0_12"/>
    <dbReference type="OrthoDB" id="390022at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="509" mass="57400" checksum="D5720FB54504A420" modified="2004-07-05" version="1">MLETADTELEFSVVFTGKSSKKVNGLYKPDTHEIILHNKNFANDNELIYTAVHEYTHHKQCEKEGGFYSTRVHSPKFWTLFHSLLAEAEKKGFYKITLEESPELLELTDEIRQVIMVEDGKLMKELGRLLGKARPLCKKAGVRYEDYVDRVLCLPRASATAIEKISAYNVNPAIGYEAMKFVANIGNAEKRAEAEEMFLNKTSPATVRGTISKKKEEDPRRTLEKEKRRLEKTILSLQARLETVESRLANMPISPFIIAVIFSIFMSLPTIGQNSNPIPIPPVPPIPGMPEIPKPNTINPVLPQVPAAPEFLKTTNQPKTEKTVTRKKISPAEMIKRLNSSQGGAFAKRLMSTLIENDDQGFDVLTKIIEELSKDNLQGFPIQTEESKNKKNVLIKNFNFNGKNMLEEFGSFAVSGITTDKSFFMAAESKAAAAGQKNGERLYIFAKRNIAGTYKLFVEIDQDTKNHSSLFFKFFKNSPFDAKLDQNILFSQIKTDRLDLDAVFDLTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R16</accession>
    <name>Q73R16_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970891.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002672691.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0277"/>
    <dbReference type="EnsemblBacteria" id="AAS10772">
        <property type="protein sequence ID" value="AAS10772"/>
        <property type="gene ID" value="TDE_0277"/>
    </dbReference>
    <dbReference type="GeneID" id="2741570"/>
    <dbReference type="KEGG" id="tde:TDE_0277"/>
    <dbReference type="eggNOG" id="COG3744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129890_0_1_12"/>
    <dbReference type="OMA" id="DSHAVYW"/>
    <dbReference type="OrthoDB" id="1872329at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd09872">
        <property type="entry name" value="PIN_Sll0205-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041705">
        <property type="entry name" value="PIN_Sll0205"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="131" mass="15663" checksum="F940FC2D50B806BE" modified="2004-07-05" version="1">MKILLDTHYLLWAFIDTSKISKSVYNKLLADENEIFYSQASLWEISIKYNMGKLSLKGMSPEEFYKEVENSFLKCRPFKNDELISFYNLPIEHKDPFDRIMIWQSIKSDYYFLSVDTQVIKYKKYGLKILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R22</accession>
    <name>Q73R22_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970885.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10766">
        <property type="protein sequence ID" value="AAS10766"/>
        <property type="gene ID" value="TDE_0271"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0271"/>
    <dbReference type="HOGENOM" id="CLU_3174424_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="47" mass="5511" checksum="FD707298E3184610" modified="2004-07-05" version="1">MACAYNTLSTLPHYIIKTNNFQPKLLKSKKNTSFYYNTNRINKQLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R24</accession>
    <name>Q73R24_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970883.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675099.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0269"/>
    <dbReference type="EnsemblBacteria" id="AAS10764">
        <property type="protein sequence ID" value="AAS10764"/>
        <property type="gene ID" value="TDE_0269"/>
    </dbReference>
    <dbReference type="GeneID" id="2741253"/>
    <dbReference type="KEGG" id="tde:TDE_0269"/>
    <dbReference type="eggNOG" id="ENOG502ZW6F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1626336_0_0_12"/>
    <dbReference type="OrthoDB" id="1795511at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="163" mass="19133" checksum="56D2180C62B9C43E" modified="2004-07-05" version="1">MAITMITTLMLMVFYFLLLYGGVAFVQNKKFFSSAPKEVYDAVPDRKERFHGAHIIGWIIIAIAFLILFGAFILGAWDGIHNNFNFIEFFIRFLIMLYGMETFDIVFFDWVLLCHSNFFPHFYPEVKDMVGSHLFGYNWKTHVIHYIIYIPICAALAWICTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R26</accession>
    <name>Q73R26_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAM1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970881.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002690264.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0267"/>
    <dbReference type="EnsemblBacteria" id="AAS10762">
        <property type="protein sequence ID" value="AAS10762"/>
        <property type="gene ID" value="TDE_0267"/>
    </dbReference>
    <dbReference type="GeneID" id="2741251"/>
    <dbReference type="KEGG" id="tde:TDE_0267"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.260"/>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_0_0_12"/>
    <dbReference type="OMA" id="CTLAFCP"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="181" mass="20771" checksum="69166929274C761C" modified="2004-07-05" version="1">MDLRFVTKNKFKVDEVQKLLTSINVIHCPIEIKEIQTESIDEIVNDKVLKAFNKIGRPLFIEHTSLYLGGMNGFPGGLTQIFWDKLQADKFSEIVSKMSDQTVEAKTVIGYCTGKKIYKFEGVIKGKISDLPKGSKDFQWDCVFIPDGHSQTFAEMGEQKNIISMRKIAFDKFYDFLKDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R38</accession>
    <name>Q73R38_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970869.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681179.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0254"/>
    <dbReference type="EnsemblBacteria" id="AAS10750">
        <property type="protein sequence ID" value="AAS10750"/>
        <property type="gene ID" value="TDE_0254"/>
    </dbReference>
    <dbReference type="GeneID" id="59369454"/>
    <dbReference type="KEGG" id="tde:TDE_0254"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.249"/>
    <dbReference type="eggNOG" id="ENOG5033J8M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1414619_0_0_12"/>
    <dbReference type="OrthoDB" id="1918683at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="192" mass="22997" checksum="85FA7D75383A5B26" modified="2004-07-05" version="1">MFPNYLDGARVRYYTNEDHFGIVDYNNGEKIISIHYLTICSYANEEGFYLLFCDEKYNVVSDYFFDSVEECKEVAKKSKENIEWIQKTDSTAEFTFEEIKTLLLKSIDEYDCEAELRLFFENNSNEYMIIIYKDRCSFQRCGNIKKSSGEYYYKTLDELYTATQVDDIILKKDWDKIITFDCEDFEILGFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R74</accession>
    <name>Q73R74_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ogt</name>
        <name evidence="10" type="ordered locus">TDE_0217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970833.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956700.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0217"/>
    <dbReference type="EnsemblBacteria" id="AAS10714">
        <property type="protein sequence ID" value="AAS10714"/>
        <property type="gene ID" value="TDE_0217"/>
    </dbReference>
    <dbReference type="GeneID" id="2741123"/>
    <dbReference type="KEGG" id="tde:TDE_0217"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.210"/>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_12"/>
    <dbReference type="OMA" id="MTYAYKL"/>
    <dbReference type="OrthoDB" id="1327994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="79"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS10714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="172" mass="19537" checksum="AC8582A0DF2BE4F4" modified="2004-07-05" version="1">MVYEYFDSPIGKILIISDNSGLKELRFIKKESITNLAEQTQDNFTKAAQICKQAKEELQKYFEGRLKQFTVQLSPEGTNFQKSVWKELCKIPYGKTLSYKQIAENLNNPKSCRAVGNANGKNPIPIIIPCHRVICTGGKLGGFSAGLDRKRFLLYLEQKECQIELIPFVDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RA4</accession>
    <name>Q73RA4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970803.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666565.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0187"/>
    <dbReference type="ESTHER" id="trede-q73ra4">
        <property type="family name" value="CarbLipBact_2"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.946"/>
    <dbReference type="EnsemblBacteria" id="AAS10684">
        <property type="protein sequence ID" value="AAS10684"/>
        <property type="gene ID" value="TDE_0187"/>
    </dbReference>
    <dbReference type="GeneID" id="2741034"/>
    <dbReference type="KEGG" id="tde:TDE_0187"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.183"/>
    <dbReference type="eggNOG" id="COG1647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076594_0_0_12"/>
    <dbReference type="OMA" id="DWYAEVD"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012354">
        <property type="entry name" value="Esterase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017388">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="2">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR017388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="255" mass="29217" checksum="3D7E60FA74A91102" modified="2004-07-05" version="1">MFFDNYPIKLSDTTKPFFLKGLKTAPAILLIHGYTGSPRDMIWLGHQLNEAGYNIYIPRLPGHGTNKNDFLTTNWKDWLRKVCDEYIDLCAMYERVFVGGLSMGGVLTSLIAARFNPEKIFLCAPAFIAADNRIKLTPFLKFFVKKIATVKKTYENDPEYGRAISDYNGVEYLAKTADLYKLQRLALKNMVFIRSQSLTVLSKADKLVPFKVKDLIDKTLRNQNDYLILEKSSHIVTNDVEKELVAKKIIEFLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RG9</accession>
    <name>Q73RG9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flagellar secretion chaperone FliS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fliS</name>
        <name evidence="7" type="ordered locus">TDE_0119</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FliS family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970736.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666704.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0119"/>
    <dbReference type="EnsemblBacteria" id="AAS10617">
        <property type="protein sequence ID" value="AAS10617"/>
        <property type="gene ID" value="TDE_0119"/>
    </dbReference>
    <dbReference type="GeneID" id="2741734"/>
    <dbReference type="KEGG" id="tde:TDE_0119"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.119"/>
    <dbReference type="eggNOG" id="COG1516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080373_3_0_12"/>
    <dbReference type="OMA" id="EFRDTWK"/>
    <dbReference type="OrthoDB" id="1730695at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16098">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003713">
        <property type="entry name" value="FliS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036584">
        <property type="entry name" value="FliS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34773">
        <property type="entry name" value="PTHR34773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02561">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039090">
        <property type="entry name" value="Flis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101116">
        <property type="entry name" value="SSF101116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00208">
        <property type="entry name" value="fliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS10617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="146" mass="16121" checksum="5C016A60E0A02E92" modified="2004-07-05" version="1">MSYNSQAAAAYKETSVKTASPGSLILMLYTEGIKEINLAISKMRVPKIPAKDIEAINNHIIKAQEIITELMAALDMDIGGEIAANLLSIYSYFNQQLLTANLKKDYKPLLDVSSMMQELYDVWKQILESQPVPQRSEVSVGVNIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RK0</accession>
    <name>Q73RK0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Trk system potassium uptake protein TrkH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trkH</name>
        <name evidence="11" type="ordered locus">TDE_0088</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970705.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680943.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0088"/>
    <dbReference type="EnsemblBacteria" id="AAS10586">
        <property type="protein sequence ID" value="AAS10586"/>
        <property type="gene ID" value="TDE_0088"/>
    </dbReference>
    <dbReference type="GeneID" id="2741703"/>
    <dbReference type="KEGG" id="tde:TDE_0088"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.89"/>
    <dbReference type="eggNOG" id="COG0168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030708_0_2_12"/>
    <dbReference type="OMA" id="LQWMGGM"/>
    <dbReference type="OrthoDB" id="756220at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006247">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006247-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS10586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="480" mass="51919" checksum="5789C1401CE833CA" modified="2004-07-05" version="1">MKALQYVRIIFMILAIISISFIIPIGTALYENEAYLIPSFLIPTAFVFAVAAAFFFFLRNKKVRLSVSGGIILVAAAWIAAGILGAIPLCISGVIPNFADAIFESVSGFTTTGATILTNVEACPMTMHVWRTQMHWLGGMGIVALTVALFPLLGVGGFHLIKSETTGPDKGKVTAKITHTAKALWFIYLGMTIVQIILLMLAGLPFLEALCHTFASLGTGGFSTRNASVGAFNSPSVEIICAVFMILAGVNFSLYFHLFTGNPEEFFHNSELKAYLKIVFVSTVLIALSIYPIYGIGGGLRQSFFQVASVITTTGFSTADYNAWPEFAKMVLFFLMFVGGCSGSTAGSIKVIRWLILQKQAGMEAKRLLSPHGVFGIQLNNRPGRKDIVYSVAGFMFCYFLLTLITALVAAADGADLLSGFTASLALIGNIGPGFGRVGPAGNFAFFSSPVKIFFSFIMLAGRLELYTMIIYFMPAFWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RP8</accession>
    <name>Q73RP8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970654.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666876.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0037"/>
    <dbReference type="EnsemblBacteria" id="AAS10535">
        <property type="protein sequence ID" value="AAS10535"/>
        <property type="gene ID" value="TDE_0037"/>
    </dbReference>
    <dbReference type="GeneID" id="2741652"/>
    <dbReference type="KEGG" id="tde:TDE_0037"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.39"/>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_1_0_12"/>
    <dbReference type="OMA" id="WEENHAN"/>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="82" mass="9150" checksum="1EBB404817103C9B" modified="2004-07-05" version="1">MELAKLTSKGQITIPLAIRNMLGLKTGDKVFFEESRGKVYITNASQITLANIQTQMQGEAEKAGFQTEDDVIAYIKELRKKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RR5</accession>
    <name>SYG_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycyl-tRNA synthetase</fullName>
            <shortName evidence="1">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyQS</name>
        <name type="synonym">glyS</name>
        <name type="ordered locus">TDE_0020</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of glycine to tRNA(Gly).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970637.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002684564.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73RR5"/>
    <dbReference type="SMR" id="Q73RR5"/>
    <dbReference type="STRING" id="243275.TDE_0020"/>
    <dbReference type="PRIDE" id="Q73RR5"/>
    <dbReference type="EnsemblBacteria" id="AAS10518">
        <property type="protein sequence ID" value="AAS10518"/>
        <property type="gene ID" value="TDE_0020"/>
    </dbReference>
    <dbReference type="GeneID" id="2741635"/>
    <dbReference type="KEGG" id="tde:TDE_0020"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.22"/>
    <dbReference type="eggNOG" id="COG0423">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_2_1_12"/>
    <dbReference type="OMA" id="EPSYGID"/>
    <dbReference type="OrthoDB" id="626850at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00253_B">
        <property type="entry name" value="Gly_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022961">
        <property type="entry name" value="Gly_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000072985" description="Glycine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="193"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="198"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="267"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="308"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="312"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00253"/>
        </source>
    </evidence>
    <sequence length="451" mass="52933" checksum="14D31C0545A35359" modified="2004-07-05" version="1">MEDHKISMEKIVSLCKRRGFVFQSSEIYGGQNGAWDYGPLGIELKNNVSRAWWKEMTQLHDNIVGLDAAILMHPRTWEASGHVENFTDPLVDCKKCKSRFRADHLPPENLEKRVCPDCGGELTDTRKFNLMFKTHIGPTDDNSSVIYLRPETAQGIYVNYKNIIQSNRMKIPFGIAQIGKAFRNEIVTKNFIFRTCEFEQMEMQFFVKPGTDDEWFDYWKKQRWAFYEKYGVRTNKLQWHQHGKDELAHYAKDAYDIEYEFPMGFKELEGVHNRTNYDLTRHTEYSGKDMQYIDQDNGNEKYIPYIIETSAGLTRNVLMFICDAYDEEKVADKGNDDDWRTVLRFHPNIAPITVAVLPLMKKDGLAELAEEIRNELKEEFKTDYDQSGAIGKRYRRQDEVGTPFCVTVDYDSKEDNTVTLRFRDSMEQVRIPRTELISRIKTEIKNYKRAH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-29" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RS4</accession>
    <name>TDXH_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peroxiredoxin</fullName>
            <ecNumber evidence="1">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_0011</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodecamer. Pentamer of dimers that assemble into a ring structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAS10509" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10509.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970628.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73RS4"/>
    <dbReference type="SMR" id="Q73RS4"/>
    <dbReference type="STRING" id="243275.TDE_0011"/>
    <dbReference type="PRIDE" id="Q73RS4"/>
    <dbReference type="EnsemblBacteria" id="AAS10509">
        <property type="protein sequence ID" value="AAS10509"/>
        <property type="gene ID" value="TDE_0011"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0011"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.13"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_4_12"/>
    <dbReference type="OMA" id="MIDYQDT"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00401">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022915">
        <property type="entry name" value="Peroxiredoxin_TDXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0049">Antioxidant</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0575">Peroxidase</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000135180" description="Peroxiredoxin">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Interchain (with C-204); in linked form" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with C-44); in linked form" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="208" mass="23381" checksum="042A131E6B35BB06" modified="2005-03-29" version="2">MPLLGDDFPQLAVSTTHGPMKLPCDLKGSWFVLFSHPADFTPVCTTEFVAFQKLMPEFEKLGVKLIGLSIDQIQSHLKWIEWIKEKLGVEITFPVIAANDSIANQIGLLHPGKGTNTVRAVFIVDPNGKVRLVLYYPQEIGRNMEEIVRAVKALQTSDKNKVALPADWPNNGLIKDRAIIPPPPTEAEAKKRLKEYDGYDFWFCHKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RS6</accession>
    <name>Q73RS6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970626.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956669.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0009"/>
    <dbReference type="EnsemblBacteria" id="AAS10507">
        <property type="protein sequence ID" value="AAS10507"/>
        <property type="gene ID" value="TDE_0009"/>
    </dbReference>
    <dbReference type="GeneID" id="2741624"/>
    <dbReference type="KEGG" id="tde:TDE_0009"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.10"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065155_0_0_12"/>
    <dbReference type="OMA" id="FIHFYFD"/>
    <dbReference type="OrthoDB" id="1962890at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="273" mass="30872" checksum="B71727BB8A1AFAF4" modified="2004-07-05" version="1">MAIITISRKIASFGDETAIELAKLLNYNFIDRKSLEKDLLAKGISEVQLKKYDERKPGFWASLSRERDSYFDYLREAVYEHASSGNSIFIGRGGFAILRNVPGLYSVRLVAADDIRISRLMKEFNYSEKEARALMEESDNNRDGFHKNFFNTVNEDSSEYNLVINTGHISHLQAAEIIKYGLEKTISKEDAALGDKRLKELLLAQKIVNHISFDLKLQIYFLEADISEHEIILHGVADNAGLIQKAIDVAQEMAGGRKVSSAISMVNEYKPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F7ITV4</accession>
    <name>F7ITV4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flagellar motor rotation protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">motB</name>
        <name evidence="7" type="ordered locus">TDE_2765</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973363.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666988.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2765"/>
    <dbReference type="EnsemblBacteria" id="AAS13282">
        <property type="protein sequence ID" value="AAS13282"/>
        <property type="gene ID" value="TDE_2765"/>
    </dbReference>
    <dbReference type="GeneID" id="2740732"/>
    <dbReference type="KEGG" id="tde:TDE_2765"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2609"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_0_1_12"/>
    <dbReference type="OMA" id="NWHLSSA"/>
    <dbReference type="OrthoDB" id="1619550at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="113"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS13282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="239" mass="25830" checksum="300EF732F243304D" modified="2011-07-27" version="1">MARKKKHGPSAAGSGWLTTYADMVTLMLCFFVMLFEPSEVDVTQLMALSASISGDPTGGGLSVSAGRLSDLGNTISSMPSMEKGKMLASALKKAVSLFAPEIKTNKIAVTSDERGIVISLASDVFFYPGSAELNIAESRDTLLNLAQFLSSQDLASYRFRVEGHTDSGVTDPNVWKSNWELSSARAINILHSLTDFGAQESRFSVAGYADTRPIFSNDTAEGRAYNRRVDIIILDDAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F7IV60</accession>
    <name>F7IV60_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar protein-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973365.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680829.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2767"/>
    <dbReference type="EnsemblBacteria" id="AAS13284">
        <property type="protein sequence ID" value="AAS13284"/>
        <property type="gene ID" value="TDE_2767"/>
    </dbReference>
    <dbReference type="GeneID" id="2740734"/>
    <dbReference type="KEGG" id="tde:TDE_2767"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2611"/>
    <dbReference type="eggNOG" id="COG1582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173020_2_0_12"/>
    <dbReference type="OMA" id="HQIESIE"/>
    <dbReference type="OrthoDB" id="2007051at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009384">
        <property type="entry name" value="SwrD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39185">
        <property type="entry name" value="PTHR39185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06289">
        <property type="entry name" value="FlbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="65" mass="7709" checksum="FD6260E80A85BB9D" modified="2011-07-27" version="1">MIQVTRLNGTKYWINPHQIETIECNPDVTLQMLSGKYYVIKERPEEILEAIVAYRRKIGIFKNEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-13" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>P60920</accession>
    <name>SYH_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="1">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisS</name>
        <name type="ordered locus">TDE_1442</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972048.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679075.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P60920"/>
    <dbReference type="SMR" id="P60920"/>
    <dbReference type="STRING" id="243275.TDE_1442"/>
    <dbReference type="PRIDE" id="P60920"/>
    <dbReference type="EnsemblBacteria" id="AAS11959">
        <property type="protein sequence ID" value="AAS11959"/>
        <property type="gene ID" value="TDE_1442"/>
    </dbReference>
    <dbReference type="GeneID" id="2741405"/>
    <dbReference type="KEGG" id="tde:TDE_1442"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1383"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_3_0_12"/>
    <dbReference type="OMA" id="YQIQKVW"/>
    <dbReference type="OrthoDB" id="277998at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000136285" description="Histidine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <sequence length="448" mass="51014" checksum="431DDC865468BF21" modified="2004-04-13" version="1">MSDLIQPKVLKGFRDFLPADEIERALLMERLVKVFRDYGFVPIDTPALEYSEILLRKSGGETEKQVFRFSDNGGRDVAMRFDLTVPLARFVAEHKSEIYFPFKRYHLGKVWRGEKPQAGRYREFLQCDFDTLGSDSAAVDFEILRLIKKALNELGVSNFKIHVSHRGIFNRFLKSLNLSEDSEEVLRIVDKLAKIGEDEVLKLLTDISSEESAKKILAYISGVSKELKSEDFEKTLSHLENLAGGPDEDTKRMRDIYALVKAVGIEDSIVFDPSITRGLDYYTGVVFETFLNDLPSIGSVCSGGRYDNLTALYMKECITGVGASIGLDRLLAALELLGHQKTKASFTDLLIFSLPEDDLVLSYKIVNFFEAEKINAEVYPEPKKMNHQYTYAEKKDIRWGLFLDKDSCVEEFDKAPQRFKIKLKDMTNRTEDETPLSEAVKKIRASKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-10-11" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q3V8B4</accession>
    <name>Q3V8B4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar biosynthesis protein FlhF</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Flagella-associated GTP-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">flhF</name>
        <name evidence="12" type="ordered locus">TDE_2686</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973284.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2686"/>
    <dbReference type="EnsemblBacteria" id="AAS13203">
        <property type="protein sequence ID" value="AAS13203"/>
        <property type="gene ID" value="TDE_2686"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2686"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2538"/>
    <dbReference type="eggNOG" id="COG1419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_11_4_12"/>
    <dbReference type="OMA" id="WYEVDEY"/>
    <dbReference type="OrthoDB" id="1162441at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020006">
        <property type="entry name" value="FlhF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF3">
        <property type="entry name" value="PTHR43134:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03499">
        <property type="entry name" value="FlhF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="10">
        <location>
            <begin position="226"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="11">
        <location>
            <begin position="227"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS13203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="446" mass="50703" checksum="B66DBB96BBA888E1" modified="2005-10-11" version="1">METFVEEASTYEKCIQKIQEKYGPNIMITRREVKRNEGFLSLFNKETIRLSFNIQNEAFVPKFSNNEEEVKSKSAVAPIKPYSPANLAEERLKIMKLAAAQSEEMAEKMMPYIEKLENQSSSPIKTDIESKEFKNLAETVERLVEEIRLKNSPSQEHENISKIAALLEENDFTAKYIRSIKEKISKNLSLAELNDFELVQKKVLDWIASSIQIKLEETNNDDPSKKQKLIALVGPTGIGKTTTLAKLAAYYILAVSKLEKRSLDVRVITIDQYRIGAAFQIKKYCEHMGIPLIIATDPLDLHKYLDLYKDSADIICIDTTGRSPTDPEKILEMQKYFDEIEPGRIETHLVVSAVTKAADIIEIIKQYSVFNFSSLIITKLDETAHVGSIISVLDEYKIPVAYITEGQTVPKDIARASKLVLLRKLTGFSLDYINENFNDEISIVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73IZ8</accession>
    <name>Q73IZ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973377.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2779"/>
    <dbReference type="EnsemblBacteria" id="AAS13296">
        <property type="protein sequence ID" value="AAS13296"/>
        <property type="gene ID" value="TDE_2779"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2779"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2623"/>
    <dbReference type="eggNOG" id="ENOG5031CE6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_885495_0_0_12"/>
    <dbReference type="OrthoDB" id="1039703at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="265" mass="29620" checksum="1B8BB216139008AE" modified="2004-07-05" version="1">MDPSIWNGTLKGNGEMFISFFINYEGSFNTNYVQKLLVESPVDMWILNSSQLEKITEIDDKAKIASVKRLQCGEGTGSVALGKWKFILTDRNGNKYEQVLDITGFEKKAQDKTGEAKAEEGNLTSAETAPANIKMIVPQSSSKNEIAALSVPVIKSVSKDSDSIEIFFSVNDERVKNGYFWFDVPGEKYYKDSGSMIDASGKPVNGCRAFSKDGKECRYILRKDDSNSDWFNKITACFFVVSDTNRVSSPWEERNRTVSAKAEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J01</accession>
    <name>Q73J01_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Proline iminopeptidase</fullName>
            <shortName evidence="4">PIP</shortName>
            <ecNumber evidence="4 6">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pip</name>
        <name evidence="8" type="ordered locus">TDE_2776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 6">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4 6">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="4 6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973374.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680838.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2776"/>
    <dbReference type="ESTHER" id="trede-q73j01">
        <property type="family name" value="Proline_iminopeptidase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S33.001"/>
    <dbReference type="EnsemblBacteria" id="AAS13293">
        <property type="protein sequence ID" value="AAS13293"/>
        <property type="gene ID" value="TDE_2776"/>
    </dbReference>
    <dbReference type="GeneID" id="2740743"/>
    <dbReference type="KEGG" id="tde:TDE_2776"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2620"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043739_2_2_12"/>
    <dbReference type="OMA" id="FYQDGAS"/>
    <dbReference type="OrthoDB" id="665798at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PTHR43722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006431">
        <property type="entry name" value="Pept_S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01249">
        <property type="entry name" value="pro_imino_pep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="7">
        <location>
            <begin position="35"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006431-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS13293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="313" mass="35751" checksum="1BBE56C0CDE16BE9" modified="2004-07-05" version="1">MKILYEKTPLFDEGFLKVSDIHSIYYAQYGNPNGKPVVFLHGGPGGGCIPVASQYFDPEFYRIVLFDQRGAGKSLPPCEMKENKSENLIEDIEKLRKHLSIKKWMVFGGSWGSTLALIYSIAHPDKVVSIILRGIFLGTQEEIDWIYEAGGASKFFPEDFEAYQNFIPLEERSSLVRAYSKRLFGEDKKLSLEAAHKWSRWESALVRLFPTVYDMSDEEALAMAKAECHYFLHKCFFKDDNYILNNCNKIKDLPCTIVQGRYDMDCPPFSAYKLHKKLPKSNLNIVLFGGHSSMEPGLVDGLVRAAEDHKKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J21</accession>
    <name>Q73J21_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973353.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13272">
        <property type="protein sequence ID" value="AAS13272"/>
        <property type="gene ID" value="TDE_2755"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2755"/>
    <dbReference type="HOGENOM" id="CLU_3349899_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="37" mass="4310" checksum="E2867CBCEB21BCDB" modified="2004-07-05" version="1">MYTTMLTHFIAFVHQKMPNFKNKLLTLFLAVGDVNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J79</accession>
    <name>Q73J79_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973295.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667090.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73J79"/>
    <dbReference type="STRING" id="243275.TDE_2697"/>
    <dbReference type="EnsemblBacteria" id="AAS13214">
        <property type="protein sequence ID" value="AAS13214"/>
        <property type="gene ID" value="TDE_2697"/>
    </dbReference>
    <dbReference type="GeneID" id="2739284"/>
    <dbReference type="KEGG" id="tde:TDE_2697"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2547"/>
    <dbReference type="eggNOG" id="ENOG502Z8VT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065395_1_1_12"/>
    <dbReference type="OMA" id="WLEWLGF"/>
    <dbReference type="OrthoDB" id="948243at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016636">
        <property type="entry name" value="3-oxo-5-alpha-steroid_4-DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="PTHR10556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015596">
        <property type="entry name" value="5_alpha-SR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="S5A_REDUCTASE" evidence="6">
        <location>
            <begin position="150"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS13214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="257" mass="30153" checksum="C326610D5C8B13C0" modified="2004-07-05" version="1">MERLIFIFNITQIVLFGVGLICFVVLFFVPAGYGKMINKKWGFSFNNKIAWFLMEVPTLITMIVLMCVWAKPENFVRIIIGLFFVLHYAQRVFIFPFLLKGKSKMPILIVLMGITFNTINAFLIGAWLFYLSPKTMYPISWLYDPRFIIGALVFLLGMAINIDSDKYIRSLRKPGDTAHYFPHKRMYKYVSSANYFGEILEWFGFALLSWSFVGLLFAFWTCANLVPRAYTINKRYREEFPEEFAALKPKRVFPFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JE1</accession>
    <name>Q73JE1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973232.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680656.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2634"/>
    <dbReference type="EnsemblBacteria" id="AAS13151">
        <property type="protein sequence ID" value="AAS13151"/>
        <property type="gene ID" value="TDE_2634"/>
    </dbReference>
    <dbReference type="GeneID" id="2740808"/>
    <dbReference type="KEGG" id="tde:TDE_2634"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2490"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060275_2_1_12"/>
    <dbReference type="OMA" id="WWTADID"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="64"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="268" mass="31486" checksum="C5EB076A8085BD83" modified="2004-07-05" version="1">MELTMYDFERYIQKDRDDAHAERMWDNKSESFYKRTEKKQKQFANDFVFHLIKDRQLLKEDSKVLDIGCGTGRHLSEFAAYTPYLTGIDISSKMLAYAQEKLRHIPQAKLIHGNWMDTFTTENQFDFVFACMTPAIASIDNIKRMCMISKKYCILERTVYEKDSIEEEIEQLLGRKLFRLPHNDKNYVYGVWNILWLMGYCPEVLVDKQVRTTSHSIEDYMHGTEYNDEEKTAVIQLLNTKAQDGIITAEESVVKAIILWDTETKLKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JF6</accession>
    <name>Y2619_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>Uncharacterized RNA methyltransferase TDE_2619</fullName>
            <ecNumber>2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_2619</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973217.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680626.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JF6"/>
    <dbReference type="SMR" id="Q73JF6"/>
    <dbReference type="STRING" id="243275.TDE_2619"/>
    <dbReference type="EnsemblBacteria" id="AAS13136">
        <property type="protein sequence ID" value="AAS13136"/>
        <property type="gene ID" value="TDE_2619"/>
    </dbReference>
    <dbReference type="GeneID" id="2740793"/>
    <dbReference type="KEGG" id="tde:TDE_2619"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2476"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_8_2_12"/>
    <dbReference type="OMA" id="FYAGDMK"/>
    <dbReference type="OrthoDB" id="1421660at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000162050" description="Uncharacterized RNA methyltransferase TDE_2619">
        <location>
            <begin position="1"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <sequence length="404" mass="46211" checksum="56EA03B32E794C20" modified="2004-07-05" version="1">MQKEIVKTKKMVFGASCIASLKDGKTVFVPYSLPDEVLEISIVKEHKNYTEGKIEKILEVSPHRVEPRCPHFYVCGGCNLQTADDEYQHFLRKSMALEALDRALSLNKEKAVFEKQALEKSFFEKSIFVSGPDWDYRARFQFYIDKDGSLSLKENKSSGSVKIKDCPIAVPAIRNLLKSNLKEYTPNSRIHIFSDGEKIFTQDNAKDCEVRLAGKRIKFNPLGFFQSNLEMTEKLINTIFEYAEISSSVLDFYSGVGTFSLFAYDQAKEIHLVEHNKHALAYAQENFLINSSSSGIVREKKENGFPKIFYHALDGKNWAKTKESKLKFDTVFVDPPRIGIDKEALSWLCSSGTRQIFYISCDPVTFARDTASLLVSGYKLEKHFLFDFYPQTHHIETLGIFRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JL2</accession>
    <name>Q73JL2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973005.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680340.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2406"/>
    <dbReference type="EnsemblBacteria" id="AAS12924">
        <property type="protein sequence ID" value="AAS12924"/>
        <property type="gene ID" value="TDE_2406"/>
    </dbReference>
    <dbReference type="GeneID" id="2740708"/>
    <dbReference type="KEGG" id="tde:TDE_2406"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2272"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_12"/>
    <dbReference type="OMA" id="IDTHAYV"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="237"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="488" mass="53589" checksum="2EA19E242EA32575" modified="2004-07-05" version="1">MIYTSESLLEAAKNAVPKAELVTLRIHRTRDTFFAAQDGAFESSGYGLDQGFMVEVLYKGHIAYGASQNMTPQGAAEAACQAFNAAKTASAFKIADFDKNVRPDTELKYETLRGKKTRPSKTEIFDYLFEICNILKVSDEVIDTHAYVNLGEEVIELLSSGGAKILQDFYTIGSSFGAAARRGDIIQRRTYNGAGARTFQGGYEFLNFAKSKVEAKRVGNEVIELLGAESCPSDRRTLVLMPDQMLLQIHESVGHPLEIDRILGDERNFAGGSFIKPEDIGSFQYGSKLMNICYDPTIPYQLATFAADQTGAQAKKTFIIKDGILVCALGSLESAGRLYAGKTVPPDKMVANQRATSWNRPPIDRMANLNLEPGTSSFDQIISSIEKGIIMTSNRSWSIDDYRNKFQFGCEYGQLIENGKITKTVRDPNYRGVSQNFWRNLCAVGDKSTFHVYGTPNCGKGEPNQVISVGHASPVCAFSDVEVFGGGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-01-04" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JP8</accession>
    <name>SELD_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Selenide, water dikinase</fullName>
            <ecNumber evidence="1">2.7.9.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Selenium donor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Selenophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">selD</name>
        <name type="ordered locus">TDE_2461</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Synthesizes selenophosphate from selenide and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate</text>
            <dbReference type="Rhea" id="RHEA:18737"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:29317"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the selenophosphate synthase 1 family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.3" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973059.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957237.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2461"/>
    <dbReference type="GeneID" id="2739646"/>
    <dbReference type="KEGG" id="tde:TDE_2461"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2328"/>
    <dbReference type="eggNOG" id="COG0709">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032859_0_0_12"/>
    <dbReference type="OMA" id="DNEPKYG"/>
    <dbReference type="OrthoDB" id="882590at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00625">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023061">
        <property type="entry name" value="SelD_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="PTHR10256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036407">
        <property type="entry name" value="Selenphspht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0711">Selenium</keyword>
    <keyword id="KW-0712">Selenocysteine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000127642" description="Selenide, water dikinase">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="51"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00625"/>
        </source>
    </evidence>
    <sequence length="354" mass="38311" checksum="043720C8C7467F12" modified="2008-02-26" version="2">MSCSLINEDFDLLKAAKNPGUGAKLSAGALDKLLKNFSVRNDDNLLVGFNTSDDAAVYKINDKTALISTIDFFPPVSGDPYIFGQVAAANSLSDIYAMGGEPKLALNLFCITKDMPEDMIKEILRGGFDKVYEAGAIVCGGHTIYDDSPKYGLAVNGFVHPKKILENSTAKEGDVLILTKPIGTGILLTASKADMSPPEELDRCYKIMAFLNAKARNIMVKYKINACTDITGFGLLGHLYEMGKGSGMSIEVDYKSVPIYKSVIESAEMGMMPAGVYSNRNFVGDNIVFENVPLAYQDLMFDPQTSGGLLISVDKEDAAALYEELSQALENTPCGKPAIIGLVTKRDEKILRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JS8</accession>
    <name>Q73JS8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973080.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680449.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2482"/>
    <dbReference type="EnsemblBacteria" id="AAS12999">
        <property type="protein sequence ID" value="AAS12999"/>
        <property type="gene ID" value="TDE_2482"/>
    </dbReference>
    <dbReference type="GeneID" id="2741455"/>
    <dbReference type="KEGG" id="tde:TDE_2482"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2348"/>
    <dbReference type="HOGENOM" id="CLU_2792793_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="68" mass="8409" checksum="BFB9D3FFC4B1F614" modified="2004-07-05" version="1">MYNKFQFNQRSGVDENLYKDKTPEQILIEKRAELFLNAAKKNPKKFIYRLKRFNLKLKYIKTNFYQNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-11-23" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JU8</accession>
    <name>RSMG_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="1">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmG</name>
        <name type="ordered locus">TDE_2513</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973111.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957250.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73JU8"/>
    <dbReference type="SMR" id="Q73JU8"/>
    <dbReference type="STRING" id="243275.TDE_2513"/>
    <dbReference type="EnsemblBacteria" id="AAS13030">
        <property type="protein sequence ID" value="AAS13030"/>
        <property type="gene ID" value="TDE_2513"/>
    </dbReference>
    <dbReference type="GeneID" id="2739025"/>
    <dbReference type="KEGG" id="tde:TDE_2513"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2379"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065341_2_0_12"/>
    <dbReference type="OMA" id="IECELSN"/>
    <dbReference type="OrthoDB" id="1590629at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000184359" description="Ribosomal RNA small subunit methyltransferase G">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Insert">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="171"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <sequence length="254" mass="28849" checksum="527D1F1DC79D90F7" modified="2004-07-05" version="1">MDTDKLLSKDLLSNGILLKGLKELGINEKAHNKLSKLLNIYMRELKMFNASFNLVKVKDDEELIVAHILDSLSAWRFFYNETKNTESKTSLNNAETKNTNEALLTSEPFYIADAGTGAGFPGVPLAALFISLGNLDVKLSLIERMQKRCTFLENIKAVLQLNNTEIIESEAEKAPQNKFDIVTCRAFHTLDKHILQTLLNLAKPKGKLFLYKAAKEKINEETELIKKEGLNYKTEKLDVPFLKKERHLLIIEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JV8</accession>
    <name>Q73JV8_TREDE</name>
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        <submittedName>
            <fullName evidence="3">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973101.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680471.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2503"/>
    <dbReference type="EnsemblBacteria" id="AAS13020">
        <property type="protein sequence ID" value="AAS13020"/>
        <property type="gene ID" value="TDE_2503"/>
    </dbReference>
    <dbReference type="GeneID" id="2741476"/>
    <dbReference type="KEGG" id="tde:TDE_2503"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2370"/>
    <dbReference type="eggNOG" id="COG2861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041643_5_1_12"/>
    <dbReference type="OMA" id="DYDAMDK"/>
    <dbReference type="OrthoDB" id="595882at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10936">
        <property type="entry name" value="CE4_DAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006837">
        <property type="entry name" value="Divergent_DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30105">
        <property type="entry name" value="PTHR30105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04748">
        <property type="entry name" value="Polysacc_deac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="390" mass="43593" checksum="C86FA03ECC05F221" modified="2004-07-05" version="1">MAKKSTKTGKTTKPVKKTGKKRRKKSKINYTGAIAGFLAVCIIMLAVFLFIIPSVKNKDETTNKTQIAKEQEKIEEEKPKTTEKPPIESKAKDKRTEKTKEAETQASKNLPKEAAKKTLHDKPKESEKAGRENKAKKPENPIITGKPKPQEQEPDVSAYPIQDLPELPSKGKLIFVFDDAGHNLEQLQYFLDLPFPCTIAVLPKLPNSRETARRIRAAGKELILHQPMQALNPNINPGDGAVKPGMDREEIKKIVASNVEEIGPIAGMNNHEGSLITSDEKAMEAVLELCREKNIYFLDSRTSSKSVVPQVAKKLNMNIWERAVFLDNKKDKAYMKKQIIEGLEIASQRGEAIMIGHVFTVDLAILLKEMYSDLTQEGYTFSTISKSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JW0</accession>
    <name>Q73JW0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973125.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680489.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2527"/>
    <dbReference type="EnsemblBacteria" id="AAS13044">
        <property type="protein sequence ID" value="AAS13044"/>
        <property type="gene ID" value="TDE_2527"/>
    </dbReference>
    <dbReference type="GeneID" id="2739039"/>
    <dbReference type="KEGG" id="tde:TDE_2527"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2391"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035211_1_2_12"/>
    <dbReference type="OMA" id="ALTQKNY"/>
    <dbReference type="OrthoDB" id="1720318at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS13044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="256" mass="27609" checksum="8F808FA40D3617D7" modified="2004-07-05" version="1">MTKKIKLFSILLFTAAVNIFSLDVPKLRGPVNDLAGILSDDKKTEIENFLFEIEKKSDVQIAVLTIPSLEGENCEEYSLRVAETWQLGSKEKDSGVLLLVAVNDKKMRIEVGYGLEANLTDAVAGRIIRNVIAPEFKTGNFGNGIFLGIKAIAGYALQDESMLSKINSSDDDSDGLAIIVGLTALFILWFIFCRLIPCFFWILYRLITLKGFTGEELVSNLFTSRSVFKFSGSSGGGGGYSGGGGSFGGGGASGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K29</accession>
    <name>Q73K29_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973186.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680575.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2588"/>
    <dbReference type="EnsemblBacteria" id="AAS13105">
        <property type="protein sequence ID" value="AAS13105"/>
        <property type="gene ID" value="TDE_2588"/>
    </dbReference>
    <dbReference type="GeneID" id="2741292"/>
    <dbReference type="KEGG" id="tde:TDE_2588"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2447"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029113_0_0_12"/>
    <dbReference type="OMA" id="GWTECAP"/>
    <dbReference type="OrthoDB" id="941208at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="178"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="400" mass="46905" checksum="BAA0E22F18D59B90" modified="2004-07-05" version="1">MGLDMKMKKKLTEETAKRYCTAGKKQKTKILDEFVATIKYNRKYAIHILKNSAYVKVTHFNNAAKKSVQIIKETRKKRNYEKYYGQDVQEQVIRLWIFSMYLCSKRLVPFIRDNIDYFAQKFGYSEQLKAKLARISSATVGRILKPEIPKHSIRGISTTRPAKNLNKLIPIRTFFDWDERKPGFFEVDTVANCGISTKGQYICTLTLTDVHSGWTENRALLNKAHRWVKEAIEDVKINLPFQMKGIDSDNGSEFKNIQLLQWCNTNNVIFTRSRSCKKNDNCFVEQKNDSVVRRIVGYYRFEGEETRSVMADLYEQYNMLVNFFFPSMKIISKHRVDAKVIKKYDEAKTPYRRLMESSDISDAEKNELQCRKDSLDLQQLIDKTQELQSKLISMAQRWST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K96</accession>
    <name>Q73K96_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mechanosensitive ion channel family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972923.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680236.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2323"/>
    <dbReference type="EnsemblBacteria" id="AAS12842">
        <property type="protein sequence ID" value="AAS12842"/>
        <property type="gene ID" value="TDE_2323"/>
    </dbReference>
    <dbReference type="GeneID" id="2739418"/>
    <dbReference type="KEGG" id="tde:TDE_2323"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2192"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045354_1_0_12"/>
    <dbReference type="OMA" id="EYIMADI"/>
    <dbReference type="OrthoDB" id="1597438at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030192">
        <property type="entry name" value="YbdG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30414">
        <property type="entry name" value="PTHR30414"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="406" mass="46216" checksum="7B4967671D8895B1" modified="2004-07-05" version="1">MQNLLGNVQKWLSEDSVRGDIFWLFAVLIVSFILHKVLKKILSGTVKKILSRITAKTKSKLDDYIFDKIHIERASLIIYIFAFNFLSLKLSFGAGLMQKLASLISIWIIIRLLHGLLDGLTAYTENEPRFAGKPYRSYVQVFILIVYIAGFIIAAGTISGKSPWSLLSGIGAMTAVLLLVFRETILSFVASLQISSYDLVRRGDWISVPKYDADGDVTEVALHTIKIQNWDKTISVLPTSDLMQSGFKNWRGMQETGGRRIKRSIFLDVSSVKFMDEELRRRVGKIELLKSYFAEVESSDISAQYGSDTEHPLNDRRLTNIGTFRMYVTRYLQSLDTLRKDLTFLVRQLEPGATGVPMEIYVFTATTDWGEYEKIQADIFDHLFASVHEFDLRIFQYPVGGFLPNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KB2</accession>
    <name>SYS_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA synthetase</fullName>
            <shortName evidence="1">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">serS</name>
        <name type="ordered locus">TDE_2307</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972907.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680220.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KB2"/>
    <dbReference type="SMR" id="Q73KB2"/>
    <dbReference type="STRING" id="243275.TDE_2307"/>
    <dbReference type="PRIDE" id="Q73KB2"/>
    <dbReference type="EnsemblBacteria" id="AAS12826">
        <property type="protein sequence ID" value="AAS12826"/>
        <property type="gene ID" value="TDE_2307"/>
    </dbReference>
    <dbReference type="GeneID" id="2740272"/>
    <dbReference type="KEGG" id="tde:TDE_2307"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2177"/>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_12"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="OrthoDB" id="353391at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000122148" description="Serine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="229"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="349"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <sequence length="422" mass="47475" checksum="FC6C81201855EE5D" modified="2004-07-05" version="1">MLDYKFIKENVEAVKQNIKNRHMNADADKAVELYDKRTALVTSLQNLQKDRNDNSQSMKQKLSPEERQKLVDQGKAIKEKIAQVEAELAEAEKALHEAVSKIPNMAHPEAPVGKEDSDNLEVKRCGTVPKFDFEPKDHVQLGQDLDLIDFEAGTKVSGVKFYFLKNEAVFLEQALTMYGLNILRKHGFKPFITPDIAKEEILYGIGFNPRGEESNVYSLEGEGTCLVATAEITLGGYHSDEIIKKESLPLKYCGLSHCFRREAGAAGQFSKGLYRVHQFSKLEMFVYCTPEESDALHEELRLIEEEIFNGLGIPFRVVDTCTGDLGAPAYRKWDLEAWMPGRNGGEWGEVTSTSNCTDYQARRLNIRYKDDDGKNKFLHTLNGTALAMSRAMIAVLENYQQADGSIKIPEALVPYCGFDRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KB7</accession>
    <name>Q73KB7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972902.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667812.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2302"/>
    <dbReference type="EnsemblBacteria" id="AAS12821">
        <property type="protein sequence ID" value="AAS12821"/>
        <property type="gene ID" value="TDE_2302"/>
    </dbReference>
    <dbReference type="GeneID" id="2740267"/>
    <dbReference type="KEGG" id="tde:TDE_2302"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2172"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_1_12"/>
    <dbReference type="OMA" id="SKDVCLM"/>
    <dbReference type="OrthoDB" id="1094814at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021812">
        <property type="entry name" value="DUF3391"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11871">
        <property type="entry name" value="DUF3391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="165"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="421" mass="47513" checksum="2B06A8F54687145C" modified="2004-07-05" version="1">MLKKIKTADLKIGERFSAPVFFDDGKNMFLLKGMALSENELNTLKRWKVQYVVTAGDPVPDGETMNDEIAELDEVDEIEDLEDPGEIEEVEEDYPISGTKIKRSEIEEISADCILKLTQDSRSMQLHTEYLEIIKSLEKVFENFKARKPVDNMPVNYHATRLIELVRKNPPLCVGFILGTELEEDNLARSSVNTAILAIILSEALELPKNRINEITIAALLHDVGMMKIPQKILNKTETLTDIEKQAVAAHTAYGYKTAMSELMYTREIALSIMQHHERWDGKGYPNGLSGKDIDIGARIITVADAFVAMITPKPYRDLMLGYQAMKNLLSDNARIFDPEIIKAMIRSVGIYPIGSIVLMNDASLARVIKSSPEAPMRPFIRILIDSTGEILDENSELVDLKKNKNLFIVRAIDPRTYRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KE8</accession>
    <name>Q73KE8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_2270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972870.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680161.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2270"/>
    <dbReference type="EnsemblBacteria" id="AAS12789">
        <property type="protein sequence ID" value="AAS12789"/>
        <property type="gene ID" value="TDE_2270"/>
    </dbReference>
    <dbReference type="GeneID" id="2740020"/>
    <dbReference type="KEGG" id="tde:TDE_2270"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2142"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_19_12"/>
    <dbReference type="OMA" id="TFANISM"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="312"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="413"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS12789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="699" mass="76166" checksum="08BFBCCF721BB719" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KF6</accession>
    <name>Q73KF6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase, U32 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972862.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680143.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2262"/>
    <dbReference type="MEROPS" id="U32.002"/>
    <dbReference type="EnsemblBacteria" id="AAS12781">
        <property type="protein sequence ID" value="AAS12781"/>
        <property type="gene ID" value="TDE_2262"/>
    </dbReference>
    <dbReference type="GeneID" id="2740012"/>
    <dbReference type="KEGG" id="tde:TDE_2262"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2134"/>
    <dbReference type="eggNOG" id="COG0826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011540_0_0_12"/>
    <dbReference type="OMA" id="YGGVSHF"/>
    <dbReference type="OrthoDB" id="1264653at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="414" mass="47278" checksum="8122E524D442372C" modified="2004-07-05" version="1">MELLSPAGNFEKLDYAWEYGADAAYIGLKNFSLRAKADNFSGEEYKNISLLKEEYKKRGLTKKLYCAINISFHNEDLKKLLEEVKYFKQYPFDAFIVQDLGAARILKESFPEISLHLSTQANCINYEAVRVYKDLGFSRVVLGREASLEDVREIKQRVPEIELECFVHGAMCISYSGRCLISAYLTDRSANAGACTHSCRWNYKMYSEKGGHFFVEESERKGEFFPVEEGENYTALFSSKDLCMIDYLDKMKEAGVDSLKIEGRMKSIYYTALTARAYRKKIDFLNGKISAAEAAPFVEELYNTAHREFSTGFYFSSAEANKTTAGESKSPYMLAGKIGKRLSENEYEFISMNKIDSGIPLEYVGPDICSIEDLDYTLLKPDTKEKMDWVCYGHPCIIKTDKPIAEKFLVRCKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KN5</accession>
    <name>Q73KN5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972783.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2182"/>
    <dbReference type="EnsemblBacteria" id="AAS12702">
        <property type="protein sequence ID" value="AAS12702"/>
        <property type="gene ID" value="TDE_2182"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2182"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2059"/>
    <dbReference type="eggNOG" id="COG1306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_351226_0_0_12"/>
    <dbReference type="OMA" id="YPSHFEQ"/>
    <dbReference type="OrthoDB" id="272884at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025275">
        <property type="entry name" value="DUF4015"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13200">
        <property type="entry name" value="DUF4015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4015" evidence="1">
        <location>
            <begin position="337"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="666" mass="76816" checksum="46CB4CE10457B439" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KR2</accession>
    <name>RL35_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmI</name>
        <name type="ordered locus">TDE_2155</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972756.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679992.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KR2"/>
    <dbReference type="SMR" id="Q73KR2"/>
    <dbReference type="STRING" id="243275.TDE_2155"/>
    <dbReference type="EnsemblBacteria" id="AAS12675">
        <property type="protein sequence ID" value="AAS12675"/>
        <property type="gene ID" value="TDE_2155"/>
    </dbReference>
    <dbReference type="GeneID" id="2739141"/>
    <dbReference type="KEGG" id="tde:TDE_2155"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2036"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169643_4_2_12"/>
    <dbReference type="OMA" id="PKIKTHR"/>
    <dbReference type="OrthoDB" id="2046660at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000177446" description="50S ribosomal protein L35">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <sequence length="66" mass="7669" checksum="8E1DEDBBEC41A944" modified="2004-07-05" version="1">MPKMKSKRAAKKRFSITASGKVKYKQMNKGHIMTKKSQKRVRRLKKSAILSEADSMKMRKQLLPYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KV9</accession>
    <name>Q73KV9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972709.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679914.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2108"/>
    <dbReference type="EnsemblBacteria" id="AAS12628">
        <property type="protein sequence ID" value="AAS12628"/>
        <property type="gene ID" value="TDE_2108"/>
    </dbReference>
    <dbReference type="GeneID" id="2740347"/>
    <dbReference type="KEGG" id="tde:TDE_2108"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1991"/>
    <dbReference type="eggNOG" id="ENOG5030VKC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1383645_0_0_12"/>
    <dbReference type="OrthoDB" id="1838410at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="197" mass="22345" checksum="1F62A0D8A23F2E10" modified="2004-07-05" version="1">MNVIKGIVRDKNKQPVSHAKVALLTERFEVIISGEADESGRFRLEADAKKYPYFIASKGFNEKFLDFWGCNIDLRKDLEINPILGKIEIFSLIFFPSLDADNCMMLYFRPMSLKQLVGKEKVIAPELSTDDITVSVNGDFYEIITMRVISETINKGVEPIRAYALKISLDGIEFDGKNKLEISIIKDDGYGEAVLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KX9</accession>
    <name>Q73KX9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C4 zinc finger domain protein, DksA/TraR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2088</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972689.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679887.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2088"/>
    <dbReference type="EnsemblBacteria" id="AAS12608">
        <property type="protein sequence ID" value="AAS12608"/>
        <property type="gene ID" value="TDE_2088"/>
    </dbReference>
    <dbReference type="GeneID" id="2740327"/>
    <dbReference type="KEGG" id="tde:TDE_2088"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1972"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_4_1_12"/>
    <dbReference type="OMA" id="CIDCKEE"/>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="119" mass="13916" checksum="504EA7B882AD18FD" modified="2004-07-05" version="1">MKKKFIEEMKEYLLKEREEILASLQKNDEEYAETLANSIPKDFADLASYSTDRDMLEFIGENNVKKLQKIDSALERIREGKYGKCITCKEQIPEDRLKALPYALKCIHCQAKSEKKMHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L21</accession>
    <name>Q73L21_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972647.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679819.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2044"/>
    <dbReference type="EnsemblBacteria" id="AAS12558">
        <property type="protein sequence ID" value="AAS12558"/>
        <property type="gene ID" value="TDE_2044"/>
    </dbReference>
    <dbReference type="GeneID" id="2740638"/>
    <dbReference type="KEGG" id="tde:TDE_2044"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1929"/>
    <dbReference type="eggNOG" id="ENOG5032HA5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_521692_0_0_12"/>
    <dbReference type="OMA" id="TMSENAD"/>
    <dbReference type="OrthoDB" id="776672at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="522" mass="60472" checksum="6446BC3877F7D30C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L27</accession>
    <name>Q73L27_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UVR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972641.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674811.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73L27"/>
    <dbReference type="STRING" id="243275.TDE_2038"/>
    <dbReference type="EnsemblBacteria" id="AAS12552">
        <property type="protein sequence ID" value="AAS12552"/>
        <property type="gene ID" value="TDE_2038"/>
    </dbReference>
    <dbReference type="GeneID" id="2740632"/>
    <dbReference type="KEGG" id="tde:TDE_2038"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1923"/>
    <dbReference type="eggNOG" id="COG3880">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102553_1_0_12"/>
    <dbReference type="OMA" id="CGKRPAT"/>
    <dbReference type="OrthoDB" id="1370308at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025542">
        <property type="entry name" value="YacH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38430">
        <property type="entry name" value="PTHR38430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015034">
        <property type="entry name" value="YacH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="165" mass="18565" checksum="75079265D3532539" modified="2004-07-05" version="1">MICDMCKLNEAKISVEQVADGVTKNIYLCPACSQRLGFGMFSETIDISITKILGSNDNDGGRKSDQCPVCGLSFREIESKKMIGCSDCFSFFKTEIMEILGKKKKNLKYSGSITDDQSPETFFETHTSEELHEELKKAVETEDYERAAALRDEIKALEKNHDIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L64</accession>
    <name>Q73L64_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligoendopeptidase F, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_2001</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972604.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679753.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2001"/>
    <dbReference type="EnsemblBacteria" id="AAS12515">
        <property type="protein sequence ID" value="AAS12515"/>
        <property type="gene ID" value="TDE_2001"/>
    </dbReference>
    <dbReference type="GeneID" id="2740454"/>
    <dbReference type="KEGG" id="tde:TDE_2001"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1890"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021290_3_1_12"/>
    <dbReference type="OMA" id="HPYMWAV"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09607">
        <property type="entry name" value="M3B_PepF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034006">
        <property type="entry name" value="M3B_PepF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011977">
        <property type="entry name" value="Pept_M3B_clade3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02290">
        <property type="entry name" value="M3_fam_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="116"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="197"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS12515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="597" mass="68033" checksum="1FC9F4C1D8922CA2" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L82</accession>
    <name>Q73L82_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972586.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679716.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1983"/>
    <dbReference type="EnsemblBacteria" id="AAS12497">
        <property type="protein sequence ID" value="AAS12497"/>
        <property type="gene ID" value="TDE_1983"/>
    </dbReference>
    <dbReference type="GeneID" id="2740436"/>
    <dbReference type="KEGG" id="tde:TDE_1983"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1872"/>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302253_0_0_12"/>
    <dbReference type="OrthoDB" id="956253at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026906">
        <property type="entry name" value="LRR_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13306">
        <property type="entry name" value="LRR_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="987" mass="105200" checksum="061BA51CD3515607" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LB9</accession>
    <name>Q73LB9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972549.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679661.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1946"/>
    <dbReference type="EnsemblBacteria" id="AAS12460">
        <property type="protein sequence ID" value="AAS12460"/>
        <property type="gene ID" value="TDE_1946"/>
    </dbReference>
    <dbReference type="GeneID" id="2740186"/>
    <dbReference type="KEGG" id="tde:TDE_1946"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1838"/>
    <dbReference type="eggNOG" id="ENOG5032GJQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796788_0_0_12"/>
    <dbReference type="OMA" id="WENETRL"/>
    <dbReference type="OrthoDB" id="866446at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284579" evidence="2">
        <location>
            <begin position="24"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="344" mass="39319" checksum="63A27FCECFABCC07" modified="2004-07-05" version="1">MKKRFFRPFSLIFSLFIAFNLFGQENTEAALSEKVLGIEGIWENGGRFIEFSRDSKKNSLDMRVVLKPYYRFVYEKMGNFSSSIETLENSKSQFYLRVNYPYAKKAVVFPVCIENGFFFTSFYKKIPYEVKEESSDNLLETKDENSSSSFDDKKNLLDGFWIEQGSPDGILLYPNEAPSSIDAYFFTGDDYIRFRYWLDDLEYNDKKVIVKGNDGTGYEFPRLLKRGSLVYSCLTNTGSILRNYETGKYTISSDSNAENTQGLFLSFKPLGAGPGTHAAPDTYPKAQFSVLENLPLYILDDGKVFAMGSPFLIRSDIKDLDAEIEKQNAKRRPPPEPSIPTEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LD2</accession>
    <name>Q73LD2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972536.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679636.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1933"/>
    <dbReference type="EnsemblBacteria" id="AAS12447">
        <property type="protein sequence ID" value="AAS12447"/>
        <property type="gene ID" value="TDE_1933"/>
    </dbReference>
    <dbReference type="GeneID" id="2740173"/>
    <dbReference type="KEGG" id="tde:TDE_1933"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1828"/>
    <dbReference type="eggNOG" id="COG3210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302253_0_0_12"/>
    <dbReference type="OrthoDB" id="914992at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044060">
        <property type="entry name" value="Bacterial_rp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18998">
        <property type="entry name" value="Flg_new_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284581" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="2">
        <location>
            <begin position="310"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_new_2" evidence="2">
        <location>
            <begin position="404"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1003" mass="107025" checksum="4592240B5420B4EE" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LI5</accession>
    <name>Q73LI5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="5">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1877</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972481.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679573.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1877"/>
    <dbReference type="EnsemblBacteria" id="AAS12392">
        <property type="protein sequence ID" value="AAS12392"/>
        <property type="gene ID" value="TDE_1877"/>
    </dbReference>
    <dbReference type="GeneID" id="2739106"/>
    <dbReference type="KEGG" id="tde:TDE_1877"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1777"/>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067442_3_0_12"/>
    <dbReference type="OMA" id="ESQYLTR"/>
    <dbReference type="OrthoDB" id="1490892at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="257" mass="28882" checksum="3474EA9172B38FD7" modified="2004-07-05" version="1">MKLLIVSAEPDKDIIRLDKKDYNYLVSVRRIKEGQVLKISLNGVKPASAEVFKINTEKKYIELRLLKEEFAFDAEPYKPRAEIILMQWLIKGNHMDIAVRQAAEAGCSLIVPVLGEFSVVKKENINQTERRERIIREARQQSGSVVNTKILPAQELKAALDSVLDYTANRKTAFIMLSEKKVGSFSFFDCLSAETEAIVLAIGCEGGIGSKEIEFLKEHKFEEVHFNTNVLRAETAAIYSIAAAQVIMEEKGGCKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LP0</accession>
    <name>Q73LP0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972426.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957068.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12337">
        <property type="protein sequence ID" value="AAS12337"/>
        <property type="gene ID" value="TDE_1822"/>
    </dbReference>
    <dbReference type="GeneID" id="2740484"/>
    <dbReference type="KEGG" id="tde:TDE_1822"/>
    <dbReference type="eggNOG" id="ENOG5032G9G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1767238_0_0_12"/>
    <dbReference type="OMA" id="IMMEDEI"/>
    <dbReference type="OrthoDB" id="2141757at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16389">
        <property type="entry name" value="FIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035615">
        <property type="entry name" value="FiwA/Osa"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="147" mass="17111" checksum="0A47B1534A83E5FB" modified="2004-07-05" version="1">MKKIDGLNIYRNANGRIIFELIGNKKYYMSSCEKLFIIIEATYFDRQWKKTNFKIQKIVANIKDKKDDCKYQDAKEGFAHGENNPVPVVNIDIKIENNNDIIPTLCNGLTRTNFLLANNVKYLVFSISKKLLLDDADSYFFIKNDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LU3</accession>
    <name>Q73LU3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972373.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669507.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1769"/>
    <dbReference type="EnsemblBacteria" id="AAS12284">
        <property type="protein sequence ID" value="AAS12284"/>
        <property type="gene ID" value="TDE_1769"/>
    </dbReference>
    <dbReference type="GeneID" id="2741213"/>
    <dbReference type="KEGG" id="tde:TDE_1769"/>
    <dbReference type="HOGENOM" id="CLU_1814951_0_0_12"/>
    <dbReference type="OrthoDB" id="1838334at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284935" evidence="1">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="142" mass="16783" checksum="553F1E9B2FB41FFA" modified="2004-07-05" version="1">MNRNIKIYIFLLFSLFSLNSKLFATAQASDILIFENETKELFTNPLDQLFLQKEEVRNKFDKIFSNYKALISTACWRGYIAKFAIKNDCLYVIDIFITISVYPKDKSEVFDTEKNSIFSELFETDIPVVCDFFYWGSYYTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LW5</accession>
    <name>Q73LW5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="8">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">nadD</name>
        <name evidence="10" type="ordered locus">TDE_1747</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 8">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + P(1),P(4)-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24252"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="8"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972351.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679466.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1747"/>
    <dbReference type="EnsemblBacteria" id="AAS12262">
        <property type="protein sequence ID" value="AAS12262"/>
        <property type="gene ID" value="TDE_1747"/>
    </dbReference>
    <dbReference type="GeneID" id="2740592"/>
    <dbReference type="KEGG" id="tde:TDE_1747"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1670"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050191_0_0_12"/>
    <dbReference type="OMA" id="FHDICKE"/>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008803">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005249">
        <property type="entry name" value="YqeK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00488">
        <property type="entry name" value="TIGR00488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HDc" evidence="9">
        <location>
            <begin position="230"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS12262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="407" mass="46146" checksum="8E555EE66E9BD625" modified="2004-07-05" version="1">MRLAILGGSFNPIHLGHLNLAFHSYKELAYDKIAIVPAYISPFKLFCKYTEVEDRLKMIDLAIADKPYMYCELYEIEKQGVSYTIDTINYLYQKFPDIEGKIGLIIGDDLKENFFRWKDAEEIIKKTDIIIGKRTGLKGSFDPLNTEPARASVKELKNEILNISSTQIRDAVLKNKDFSSLVPKGVYDYIIEHGLYKEKGVLALGVSALMDTSDIELKTREIDRFAKSVLTESRYAHSVRVAEYARHLAKEYKKEGVSPALAYFTGLAHDICKKCSDEELVKLVEADGLGIDNVEKNRLNLLHGRASAIVLQKKFGINDESVLKAVAFHTFGYEGIDALGKIIYIADKIEPGRPDTENFRNMVKSSSLNELMLAVLDWNLAYIKKKGASIHPETKKMYEQIQKELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M33</accession>
    <name>Q73M33_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb</name>
        <name evidence="6" type="ordered locus">TDE_1677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972282.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669349.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1677"/>
    <dbReference type="EnsemblBacteria" id="AAS12193">
        <property type="protein sequence ID" value="AAS12193"/>
        <property type="gene ID" value="TDE_1677"/>
    </dbReference>
    <dbReference type="GeneID" id="2740132"/>
    <dbReference type="KEGG" id="tde:TDE_1677"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1603"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_6_0_12"/>
    <dbReference type="OMA" id="GQMQERT"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002070">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="168" mass="18530" checksum="C1EFEC45A71868AC" modified="2004-07-05" version="1">MADINHVVLVGRLTRDAELKYTSSGIAVCNFAIAVNRRRKTGDDWSEEASFFDVVLWGRQGEALNQYLVKGKQVAIDGELRQNRWEQDGQTRSKVEIVANNIQLVGGSAGQGGQSQAAPQRQGSYQGGGNNSYNDGNQAPSAYQRRQEPSYDDYQPDMGNSDLDNIPF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M35</accession>
    <name>RL9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplI</name>
        <name type="ordered locus">TDE_1675</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972280.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679371.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M35"/>
    <dbReference type="SMR" id="Q73M35"/>
    <dbReference type="STRING" id="243275.TDE_1675"/>
    <dbReference type="EnsemblBacteria" id="AAS12191">
        <property type="protein sequence ID" value="AAS12191"/>
        <property type="gene ID" value="TDE_1675"/>
    </dbReference>
    <dbReference type="GeneID" id="2740130"/>
    <dbReference type="KEGG" id="tde:TDE_1675"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1601"/>
    <dbReference type="eggNOG" id="COG0359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078938_1_2_12"/>
    <dbReference type="OMA" id="CKDGKAN"/>
    <dbReference type="OrthoDB" id="1959318at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000236614" description="50S ribosomal protein L9">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="199" mass="22355" checksum="B1237A2FB7B4602D" modified="2004-07-05" version="1">MKVILNEDVKYLGEEGDIKNVAKGYARNYLFPRNLAVPCNEFTLAHFESRKEEIEAKKAAKRQDAAGLKEKLEALSIKILMPAGPNGKLYGAVTTQTLFDELQKLNFDIERKRIEILGQTVKSTGVHKAIVKLYENTSAEISFTVEAQIAEEKPVKASEKKGRRPRRDEEASDEQILAEENSVTEEAVSEEIQNSESEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-15" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M37</accession>
    <name>CLPX_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpX</name>
        <name type="ordered locus">TDE_1673</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972278.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679368.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M37"/>
    <dbReference type="SMR" id="Q73M37"/>
    <dbReference type="STRING" id="243275.TDE_1673"/>
    <dbReference type="PRIDE" id="Q73M37"/>
    <dbReference type="EnsemblBacteria" id="AAS12189">
        <property type="protein sequence ID" value="AAS12189"/>
        <property type="gene ID" value="TDE_1673"/>
    </dbReference>
    <dbReference type="GeneID" id="2740128"/>
    <dbReference type="KEGG" id="tde:TDE_1673"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1599"/>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_12"/>
    <dbReference type="OMA" id="HYKRVQA"/>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000160447" description="ATP-dependent Clp protease ATP-binding subunit ClpX">
        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ClpX-type ZB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="117"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <sequence length="415" mass="45548" checksum="7BE3E28AB41F8EB2" modified="2004-07-05" version="1">MARNRMGGALICSFCNKPESSERFVVPGPGGIAICDRCVDLCESYIKSYKTVRPVDRSGAIPTPQELKEYLDEYVIGQEQAKRVLSVAVYNHYKRIMNPPLENDVVIEKSNVLLLGPTGSGKTLLAKTLAQKMQVPFAIADATTLTEAGYVGEDVENILLKLIQNANGDIKEAEMGIIFIDEIDKISRKSENVSITRDVSGEGVQQALLKIIEGTSASVPPQGGRKHPNQDMLKIDTTNILFICGGAFVGLDKIVEARISTKPIGFGAEVKKLSEKNLTELYDQVSPDDLVKFGLIPELIGRIPIKVALNELTKEDLTRILVEPKNAIIKQFQATFKLDNVDLHFDKDAITAIAQQAIDQNTGARGLRSIVEKLMLDAMFEAPSIKGRKELIINKKMIGNSSSKPKIKLLDEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M46</accession>
    <name>Q73M46_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972269.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669316.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1664"/>
    <dbReference type="EnsemblBacteria" id="AAS12180">
        <property type="protein sequence ID" value="AAS12180"/>
        <property type="gene ID" value="TDE_1664"/>
    </dbReference>
    <dbReference type="GeneID" id="2739005"/>
    <dbReference type="KEGG" id="tde:TDE_1664"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1591"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068891_0_0_12"/>
    <dbReference type="OMA" id="KESEQTY"/>
    <dbReference type="OrthoDB" id="515333at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284599" evidence="1">
        <location>
            <begin position="21"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="346" mass="37884" checksum="19FB750BF7BA3951" modified="2004-07-05" version="1">MIKKIFFVAVCSLLVVSAWAQAPSIVGTDYVRPAIHYVEEGTNYVNSDVFFKLRSTDKETGLDFVEFALNGADFMRYKNPFQLLEEGKYDISYRGFDNSGNLELPKTLSVIVDNTAPDTMIKTTAPLYNDGVVVYCSADTKWYVSAADIVGGSGVAAGYMGTDLNSLKISGNGKESEQTYVSLDGEGPVNLYYTAIDNVGNLAPIKLLAVTIDRTAPVVSIANSNRLINKDEEYMVFPSDRVVDEEGRVIVSTSETVSFAAKDDLSGVDAIYVKVNDGEYTKYVEPIRFTQNAVYKIEVKAIDNVGNVSEPVMYTFYVDQITPNSEVDIIDRSGNLLPATTPANAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M68</accession>
    <name>RPIA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-5-phosphate isomerase A</fullName>
            <ecNumber evidence="1">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoriboisomerase A</fullName>
            <shortName evidence="1">PRI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpiA</name>
        <name type="ordered locus">TDE_1641</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972247.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679325.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M68"/>
    <dbReference type="SMR" id="Q73M68"/>
    <dbReference type="STRING" id="243275.TDE_1641"/>
    <dbReference type="EnsemblBacteria" id="AAS12158">
        <property type="protein sequence ID" value="AAS12158"/>
        <property type="gene ID" value="TDE_1641"/>
    </dbReference>
    <dbReference type="GeneID" id="2739750"/>
    <dbReference type="KEGG" id="tde:TDE_1641"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1569"/>
    <dbReference type="eggNOG" id="COG0120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_1_1_12"/>
    <dbReference type="OMA" id="YDWDEVN"/>
    <dbReference type="OrthoDB" id="1681738at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00170">
        <property type="entry name" value="Rib_5P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020672">
        <property type="entry name" value="Ribose5P_isomerase_typA_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="PTHR11934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000158488" description="Ribose-5-phosphate isomerase A">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00170"/>
        </source>
    </evidence>
    <sequence length="239" mass="25917" checksum="AE7624B22CE20E15" modified="2004-07-05" version="1">MDTSQLKERVAYHAIDTLFSEGKIFDGMKIGLGTGSTAMPAVHRLAQLLSSGKLKKIYAVPTSFQTSIECEKLGIPIYSLSSQQIGGSLDLAIDGADEIDPDKNLIKGGGAALLKEKIIAYNSKEFVVIADERKKVKSMGKGFALPIEIIPEARLSITKALEAQGIEVFLREGVKKMGPVVTDNGNFIIDVKWPKAADVDPKALEESLNKITGVVENGFFTKNTPRVFIVHQDGNIEDL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M76</accession>
    <name>CITD_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Citrate lyase acyl carrier protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Citrate lyase gamma chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">citD</name>
        <name type="ordered locus">TDE_1633</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Covalent carrier of the coenzyme of citrate lyase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Oligomer with a subunit composition of (alpha,beta,gamma)6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CitD family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972239.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669237.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M76"/>
    <dbReference type="SMR" id="Q73M76"/>
    <dbReference type="STRING" id="243275.TDE_1633"/>
    <dbReference type="EnsemblBacteria" id="AAS12150">
        <property type="protein sequence ID" value="AAS12150"/>
        <property type="gene ID" value="TDE_1633"/>
    </dbReference>
    <dbReference type="GeneID" id="2739742"/>
    <dbReference type="KEGG" id="tde:TDE_1633"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1561"/>
    <dbReference type="eggNOG" id="COG3052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158489_0_0_12"/>
    <dbReference type="OMA" id="YNWKEID"/>
    <dbReference type="OrthoDB" id="1966288at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00805">
        <property type="entry name" value="CitD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006495">
        <property type="entry name" value="CitD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023439">
        <property type="entry name" value="Mal_deCO2ase/Cit_lyase_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06857">
        <property type="entry name" value="ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002736">
        <property type="entry name" value="Citrt_lyas_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01608">
        <property type="entry name" value="citD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000214717" description="Citrate lyase acyl carrier protein">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(phosphoribosyl dephospho-coenzyme A)serine" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00805"/>
        </source>
    </evidence>
    <sequence length="87" mass="9807" checksum="7EC8FB381DC17C64" modified="2004-07-05" version="1">MQIKREAVCGTLQSNDCLVRIVPSEKLELDLKSSVLNEFGAQIKKTVQEVLDEFEVKNAKLFIEDKGALDCTIKARVETALRRANEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MJ8</accession>
    <name>Q73MJ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972116.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669020.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1510"/>
    <dbReference type="EnsemblBacteria" id="AAS12027">
        <property type="protein sequence ID" value="AAS12027"/>
        <property type="gene ID" value="TDE_1510"/>
    </dbReference>
    <dbReference type="GeneID" id="2739716"/>
    <dbReference type="KEGG" id="tde:TDE_1510"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1449"/>
    <dbReference type="eggNOG" id="COG0672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023979_2_0_12"/>
    <dbReference type="OMA" id="RWQAFIR"/>
    <dbReference type="OrthoDB" id="433945at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="PTHR31632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="422" mass="46960" checksum="9516B60D33A32D6A" modified="2004-07-05" version="1">MFNNSFKRFLSIFLIFFAFLFSVSAKEKEDLSTWTKIVEKMEIHLNNAYELYTQGKTREAYDEVNAAYFRYYESKGMEKITMSYLSGARKTAVENAFYEYRKNVKSDKDNEMIRAHKDALIAMLYHDAAELDGTSNDKGGSGKSAAVATFISCFVLILREGLEAILVIAAIIAYLVKTGKKKYISSVYIGALAGILVSIVLAFLFGLLAGAQSGIAQEVFEGIGMFVAVIVLFYVSNWMISKSETEAWERYIKKKVESSVSTGNKWVLIFAAFIAVAREGAELILFFQGVPVQGASGQRAMILAIVLSVIILAGVFLAFRFLSVKLPLKPFFTVTSILMYILCFSFTGKGVSELQAAGVVGKTIIPWMQSFELDFLGIYATYESLIPQIIVLITIIVFSSLYVKKNKKILAELKKKEEGGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ML8</accession>
    <name>Q73ML8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972096.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679153.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1490"/>
    <dbReference type="EnsemblBacteria" id="AAS12007">
        <property type="protein sequence ID" value="AAS12007"/>
        <property type="gene ID" value="TDE_1490"/>
    </dbReference>
    <dbReference type="GeneID" id="2739891"/>
    <dbReference type="KEGG" id="tde:TDE_1490"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1429"/>
    <dbReference type="eggNOG" id="ENOG5032GN8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_717531_0_0_12"/>
    <dbReference type="OrthoDB" id="2110812at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285990" evidence="1">
        <location>
            <begin position="25"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="385" mass="43672" checksum="53086FE480638523" modified="2004-07-05" version="1">MSIKSKKIKFLLFFFLIKTSLVFSQGFSVPHFENTNTFYGLTTKPYVTADSLIQLKLRMEPSNKFYFDMNIDANIDKLIDFFSQAQDPKFDGNFRFLGASLNFPKIQNRPLSFAVFTGTYDTLGSDSILQEHLKVKMPDPEFRRYHPASAFRPRNFVQGTGFGIYGAFFSGFYLGTYLTWNEKLGDNLQIKSDFRMGGAFDFFAFDFFAGASFPKNVIKTKIRSGLAMLFQADDSYDFFTEVGIAEIKIENIDVKDFTSNFYASFEARIKKDLIRSNIACFVAPVFLLPKSINDPLLKDSFFTGLSADVGIGNLETKNMEGGIHLMGTVNPLKPTMITPFSFLISPFYTIRADGFTLDFRLPVNPLLYNDISKMITAQISIKAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MM2</accession>
    <name>Q73MM2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_34 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972092.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1486"/>
    <dbReference type="EnsemblBacteria" id="AAS12003">
        <property type="protein sequence ID" value="AAS12003"/>
        <property type="gene ID" value="TDE_1486"/>
    </dbReference>
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    <dbReference type="KEGG" id="tde:TDE_1486"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1425"/>
    <dbReference type="eggNOG" id="COG1733">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_142189_1_0_12"/>
    <dbReference type="OMA" id="LRLAIMS"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027395">
        <property type="entry name" value="WH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13601">
        <property type="entry name" value="HTH_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_34" evidence="1">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="104" mass="11856" checksum="5D61D2C20BA30BDF" modified="2004-07-05" version="1">MSIPDNTETSFDHRLIDEQLSSRLRLAVMSVLIGCEKIEFTLLREKVNATDGNLTAHCKKLENAGYLKVEKLFVNRKPLTLYSVTDEGRKAVKNYIKQLTSLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MP9</accession>
    <name>Q73MP9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972065.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679116.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1459"/>
    <dbReference type="EnsemblBacteria" id="AAS11976">
        <property type="protein sequence ID" value="AAS11976"/>
        <property type="gene ID" value="TDE_1459"/>
    </dbReference>
    <dbReference type="GeneID" id="2741574"/>
    <dbReference type="KEGG" id="tde:TDE_1459"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1400"/>
    <dbReference type="eggNOG" id="ENOG5030KHU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894125_0_0_12"/>
    <dbReference type="OMA" id="GEDICSK"/>
    <dbReference type="OrthoDB" id="1485160at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="311" mass="35696" checksum="CC07568957F8DFC0" modified="2004-07-05" version="1">MGLRQKAEAVSIKAYQPSQAPTERPHSPFFDAKNNFQALLNNLQIEKGGFLVKANEDFYNLCFAAGVDITTFHRCMIPSSIIEGFEAKQNNRYSLTNKDLSSIKNFFSSQEYISITDIILYPLEEAKTFLFLIKSQKDFYREAFDFEKADKLVKEFLPYYDQYKQIIETARPVYPFQYGTDTIMLKIKSALNLNNTAHLLKISFLHVFTDRVTLQSDLNTLELYYSMINKILNLIGKSNMAMLGMDNNLYASIFSSETLPMDIYTQKITASLSKIYGEDICSKILMDYTGTSKDINEIKTFFKAVINDKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MQ6</accession>
    <name>Q73MQ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972058.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1452"/>
    <dbReference type="EnsemblBacteria" id="AAS11969">
        <property type="protein sequence ID" value="AAS11969"/>
        <property type="gene ID" value="TDE_1452"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1452"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1393"/>
    <dbReference type="HOGENOM" id="CLU_3141870_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="49" mass="5870" checksum="D471E5BB686D4987" modified="2004-07-05" version="1">MHSPMKGNTFVLPKEKHLKKRNSLETKKIIKRFSSSFFPSYYSIIITYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MS0</accession>
    <name>Q73MS0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Capsular polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972043.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679062.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1437"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="DNASU" id="2741400"/>
    <dbReference type="EnsemblBacteria" id="AAS11954">
        <property type="protein sequence ID" value="AAS11954"/>
        <property type="gene ID" value="TDE_1437"/>
    </dbReference>
    <dbReference type="GeneID" id="2741400"/>
    <dbReference type="KEGG" id="tde:TDE_1437"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1378"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_25_1_12"/>
    <dbReference type="OMA" id="CIYIKEN"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="324" mass="37424" checksum="9C748B47F83BD59B" modified="2004-07-05" version="1">MNNMLLSIVIPAYNAERFLHNLLSFLVEQVFECKKHSIEVIIVNDGSQDSTKKIAEDFSNKYPFITVINQENKGECGARNTGIKCAKGKYLYFLDSDDTIPVGTLAFFQQLLLGSNDIDVFNFGYEVERNGQVCKIVSSAQLDKRHFNDNSIKKNFLSKKMPCCICSSIYKKDFIYDNDLFFPVGIKIGGDLVFMVNAFTKSNSAYYSKRICFIYQIRDDSVMQGYKSYNMDRIKSFEIVRDTIIDNAEYYSLVKKEANFFIANLYLANLVAYLKSNVKDKEINKIFIQNKFFLYKSIKGRFINRMAILVARCVPLRLLLKIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MT1</accession>
    <name>Q73MT1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase, DegT/DnrJ/EryC1/StrS family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972032.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679043.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1426"/>
    <dbReference type="EnsemblBacteria" id="AAS11943">
        <property type="protein sequence ID" value="AAS11943"/>
        <property type="gene ID" value="TDE_1426"/>
    </dbReference>
    <dbReference type="GeneID" id="2739703"/>
    <dbReference type="KEGG" id="tde:TDE_1426"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1367"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_6_0_12"/>
    <dbReference type="OMA" id="IHTQIHY"/>
    <dbReference type="OrthoDB" id="1006364at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="368" mass="41653" checksum="5D517616B0979414" modified="2004-07-05" version="1">MYIPFLSLQKITESFEPYLSQKINEVVKKGWYIHGEECKAFEKEFAEFCGVKYCIGVGNGLEALKLILRAYKLLGVFQEGDEIIVPSNTFIATILAVSAENLTPVFVEPDINDYLIDVEKIEDKISSKTKAIMPVHLYGRLCNMEAITAFAKQHNLRVIEDAAQAHGAKQTEKRSGAFGDAAGFSFYPGKNLGCLGDGGCVTTDYDELADVVRKLANYGSSIKYVHEYKGENSRLDEIQAAVLSVKLQRLDADNNRRRQIAAMYNAGIKNKAVILPKLHQKEEHVWHIYCVRVQNRKAFINYLKDCGIETVIHYPTPPHKQKAYKEFSHLYLPISEKIHAEVVSLPMSPLLTDEEVNYVIEKVNEWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MU0</accession>
    <name>Q73MU0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_1417</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972023.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679021.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1417"/>
    <dbReference type="EnsemblBacteria" id="AAS11934">
        <property type="protein sequence ID" value="AAS11934"/>
        <property type="gene ID" value="TDE_1417"/>
    </dbReference>
    <dbReference type="GeneID" id="2739694"/>
    <dbReference type="KEGG" id="tde:TDE_1417"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1359"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_101_4_12"/>
    <dbReference type="OrthoDB" id="887953at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="46"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="78"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="411" mass="46281" checksum="8E104B9F9D529E1D" modified="2004-07-05" version="1">MSNTVIKIEHLSKMYKLGVINNGALFRDIQSWWALKRGKEDPHGKIGADKYEGSDTEFWALKDLTFDIKQGDRVGIIGKNGAGKSTLLKALSRITTPTEGTVKIRGKVSSLLEVGTGFHGELTGRENIYLNGAILGMKKREIDRKLDEIIDFSGIEKHIDTPVKRYSSGMYVRLAFAVAAHLDSDILIADEVLAVGDAEFQKKAIGKMSELSTGQGRTVLFVSHNMAAVKSLCNKGVILEKGRLKFTSDNIDDSISYYMGTGDRGEISRPTIWINHGDIYHPNFIPKRLEVVDMSGKQFDRPINYEEGFKIRITFDINELDEMFDFGLYIYFQNMRLMIITGVYNIAKLQKKDNVSEFTIPPKFFIPNNSYLVSIFSSIRNCNWIIDPDDYIASVLIPITDTDFTIKGMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MV1</accession>
    <name>Q73MV1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1406</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972012.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668791.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1406"/>
    <dbReference type="EnsemblBacteria" id="AAS11923">
        <property type="protein sequence ID" value="AAS11923"/>
        <property type="gene ID" value="TDE_1406"/>
    </dbReference>
    <dbReference type="GeneID" id="2741273"/>
    <dbReference type="KEGG" id="tde:TDE_1406"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1348"/>
    <dbReference type="eggNOG" id="ENOG5032KM3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1214343_0_0_12"/>
    <dbReference type="OMA" id="RMDIIAY"/>
    <dbReference type="OrthoDB" id="987191at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019657">
        <property type="entry name" value="ComFB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10719">
        <property type="entry name" value="ComFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="233" mass="26756" checksum="E2DBB33CE309EEBC" modified="2004-07-05" version="1">MIIHNVMEDLVYTEVNKLFDEAEEKKESWLTCSCMQCRVDTMCYVLNRVKPRYIKSGRGLAHFLKFEKTEKVQIMADITSLVIEGMHRVLSTKRPHDHEPIFETENTPVFNFPAITGNILNGSNFRPMEDATISLKMNGELVSQMSILWDNPYTISEKTPGAYTFCPKAIPAKNAGDKEKFIFVLKAEKEGFDPTNFSFDIELTAEDMVKSPLDSSNFYQIKNLFLCEHSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N40</accession>
    <name>Q73N40_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971922.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1316"/>
    <dbReference type="EnsemblBacteria" id="AAS11833">
        <property type="protein sequence ID" value="AAS11833"/>
        <property type="gene ID" value="TDE_1316"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1316"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1265"/>
    <dbReference type="HOGENOM" id="CLU_2811179_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="67" mass="7886" checksum="9A9DE8611B58DB6E" modified="2004-07-05" version="1">MENLNLIDEKIKTDKTNTIIGFDLLLDGDENKPLKSKSFISVYEENFLIYKKIYETCALIYPLKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N43</accession>
    <name>Q73N43_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase I</fullName>
            <ecNumber evidence="3">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971919.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956947.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1313"/>
    <dbReference type="EnsemblBacteria" id="AAS11830">
        <property type="protein sequence ID" value="AAS11830"/>
        <property type="gene ID" value="TDE_1313"/>
    </dbReference>
    <dbReference type="GeneID" id="2739571"/>
    <dbReference type="KEGG" id="tde:TDE_1313"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1262"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127725_0_0_12"/>
    <dbReference type="OMA" id="DIMIAEG"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S26" evidence="4">
        <location>
            <begin position="12"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="178" mass="20675" checksum="20D1D9F2D235CD2E" modified="2004-07-05" version="1">MFKKTKRKLFYFFCFIFFFAFIKSCVFDVKKVSGPSMEPSLKDGDCVFIFKFAYGIKHPLNNKYIFRWARPKSGDIIVYRKDGHFTIKRCLGISEEPIEFSKKLGYNYDYSMKVSGKNIPLTAIQFRNLGGMSDKEKVRVPAGYVLALGDNLKESHDSRDYGFVLVDGIYGKVFIWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N60</accession>
    <name>Q73N60_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal subunit interface protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971902.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671537.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1296"/>
    <dbReference type="EnsemblBacteria" id="AAS11813">
        <property type="protein sequence ID" value="AAS11813"/>
        <property type="gene ID" value="TDE_1296"/>
    </dbReference>
    <dbReference type="GeneID" id="2741050"/>
    <dbReference type="KEGG" id="tde:TDE_1296"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1246"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182060_0_0_12"/>
    <dbReference type="OMA" id="QAINYHL"/>
    <dbReference type="OrthoDB" id="2088581at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="96" mass="11450" checksum="AA06ED86908C891B" modified="2004-07-05" version="1">MNINIQAVKFTMDEDQKKYLDQKFKRIEYADNLITDIQCFIKLDKKFIYDTTINFRWGGTAHVSTENYEFEAGVNKMMDIADQKVKKEKDKVQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N63</accession>
    <name>Q73N63_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TldD/PmbA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1292</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971899.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678796.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1292"/>
    <dbReference type="EnsemblBacteria" id="AAS11810">
        <property type="protein sequence ID" value="AAS11810"/>
        <property type="gene ID" value="TDE_1292"/>
    </dbReference>
    <dbReference type="GeneID" id="2741046"/>
    <dbReference type="KEGG" id="tde:TDE_1292"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1241"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051502_0_0_12"/>
    <dbReference type="OrthoDB" id="958356at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_M" evidence="4">
        <location>
            <begin position="116"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="230"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="435" mass="47357" checksum="A500B3BD38DD66E6" modified="2004-07-05" version="1">MSGFDGIKHAEFILDALKKEGADKATTRVSKSVKSEMNIDAGRLSLYRSTTDISVAMTSLVETKKGHISGNDLSEKTLKEEAAKVVALSRSSEKDDGNDIAPMQKGETLSYGDTEPNNEKMYERLKEFLDYTKSAYPTLQLNQCVLDFTRSEQILANSNGVRFTQSSGIYNFTAMFFAKDDKGTSSFNYSGAAHLNLDKPLKDWGNLDEIMRENCGQTVTAPLSGSFKGDIVITPMSMIDFAGTMIGLFMSNMPLITGTSIWKDKLNQKVLSDLFTLHSFPRRPAGTELESLYTGDGFKTENKTLIEKGVLKDFVLSLYGSKKTGLPRCVSGGEGLIIESGNTAKADMIKNVKKGILLGRFSGGNPAANGDFSGVAKNSYLIENGEITKPLSETMIAGNIVKMFSDIISVSKEKVDYGNAIVPWMHSTGITISGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-07-19" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N90</accession>
    <name>ISPG_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="1">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispG</name>
        <name type="ordered locus">TDE_1265</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971872.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678768.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73N90"/>
    <dbReference type="SMR" id="Q73N90"/>
    <dbReference type="STRING" id="243275.TDE_1265"/>
    <dbReference type="EnsemblBacteria" id="AAS11783">
        <property type="protein sequence ID" value="AAS11783"/>
        <property type="gene ID" value="TDE_1265"/>
    </dbReference>
    <dbReference type="GeneID" id="2740558"/>
    <dbReference type="KEGG" id="tde:TDE_1265"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1216"/>
    <dbReference type="eggNOG" id="COG0821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042258_0_0_12"/>
    <dbReference type="OMA" id="PTCGRTQ"/>
    <dbReference type="OrthoDB" id="665306at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000190647" description="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <sequence length="387" mass="42460" checksum="B4E49C6072E37513" modified="2004-07-05" version="1">MNSIKLPRTIHIGGKGQVKKLTLGGTSPILLQTMWKESLLGADLLSIVKSLNELEQLGCDIVRFAVPDMDSAEQFVKLTRLTEMPLVADIHFDYKLALRCMDGDTAKIRINPGNIGSKEKTEEVIRKAKDTGTAIRIGVNSGSLPSDLKKKIEEANSKRNLSGDKKALDDEISLLRADTLTEAAARELEIFEKADFKDAVVSMKASNVRETVMANEIFAKKFDNPLHLGVTEAGPLIQGIVKSTIAFYRLLEQNIGSTIRVSLSDSCENEVIAGREILTECGKRQGGIRLISCPRCGRKGFDVQAFVKRWQTKLLSEKKDISIAVMGCVVNGPGEGKHADLGITGAEDSVIIFKHGAITKRLDLKKLTEEEKIKAVDKAFIEELQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NC2</accession>
    <name>Q73NC2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971840.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11751">
        <property type="protein sequence ID" value="AAS11751"/>
        <property type="gene ID" value="TDE_1233"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1233"/>
    <dbReference type="HOGENOM" id="CLU_2195766_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="108" mass="11471" checksum="8C47DE22C40F259F" modified="2004-07-05" version="1">MPLSAVNVFSALSTTCSSPATVIVICAGVDPPPCCGEDGTELFPTGFLQLANNNTANNISLGICFISLNYLHNFKVNSHRLVTVNNSEFFLKCQAKENSLCDNSGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ND5</accession>
    <name>Q73ND5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971827.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956927.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1220"/>
    <dbReference type="EnsemblBacteria" id="AAS11738">
        <property type="protein sequence ID" value="AAS11738"/>
        <property type="gene ID" value="TDE_1220"/>
    </dbReference>
    <dbReference type="GeneID" id="2740114"/>
    <dbReference type="KEGG" id="tde:TDE_1220"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1175"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347775_0_0_12"/>
    <dbReference type="OMA" id="NITEYLW"/>
    <dbReference type="OrthoDB" id="232547at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="810" mass="94585" checksum="47ED0F65332B94FF" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NG2</accession>
    <name>Q73NG2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971798.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677676.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1191"/>
    <dbReference type="EnsemblBacteria" id="AAS11709">
        <property type="protein sequence ID" value="AAS11709"/>
        <property type="gene ID" value="TDE_1191"/>
    </dbReference>
    <dbReference type="GeneID" id="2741152"/>
    <dbReference type="KEGG" id="tde:TDE_1191"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1148"/>
    <dbReference type="eggNOG" id="ENOG5032MK4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126479_1_0_12"/>
    <dbReference type="OrthoDB" id="2123601at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284618" evidence="1">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="141" mass="16337" checksum="00FD387ED96C7518" modified="2004-07-05" version="1">MKIIKKISFLAAIMICFVFCFACSKDSDKGGYKTNYKAIADALNKQCPTKIDENIQLDAVEYIESSHTLQYVYSFTEMVKENNTPEVWNIIEAATREALITEFKSQTNIEQFRKDKLNMSFVYKDKDKEHLFTIVLNSGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NK6</accession>
    <name>Q73NK6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971754.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956893.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1146"/>
    <dbReference type="EnsemblBacteria" id="AAS11635">
        <property type="protein sequence ID" value="AAS11635"/>
        <property type="gene ID" value="TDE_1146"/>
    </dbReference>
    <dbReference type="GeneID" id="2740005"/>
    <dbReference type="KEGG" id="tde:TDE_1146"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1105"/>
    <dbReference type="HOGENOM" id="CLU_1389673_0_0_12"/>
    <dbReference type="OrthoDB" id="1831779at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="196" mass="22339" checksum="E7DF76CD677652FB" modified="2004-07-05" version="1">MNIDRQLANRALSAVGEPQLNETDKESKSFLLVKKFYLPTMLESLEMIPWTSGKKRARLEKDLSENHTDYSGAFKLPIDCGKIIELKDKSYYIVEGKTLYTDAAEAVLLYITNGKLPEGMGNVDDDFPDYDPPEYEAMFYQAFELRLASKFALELSGKPELHKMLLQEAAMIEEAAYRNTKTLSAGKKKGNSWWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NY6</accession>
    <name>Q73NY6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971623.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682329.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1014"/>
    <dbReference type="EnsemblBacteria" id="AAS11504">
        <property type="protein sequence ID" value="AAS11504"/>
        <property type="gene ID" value="TDE_1014"/>
    </dbReference>
    <dbReference type="GeneID" id="2740994"/>
    <dbReference type="KEGG" id="tde:TDE_1014"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.974"/>
    <dbReference type="eggNOG" id="ENOG5030273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_741742_0_0_12"/>
    <dbReference type="OrthoDB" id="1670555at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="365" mass="41345" checksum="2831E06BB45B46B8" modified="2004-07-05" version="1">MSDFFVSEILVLILLILPLIRPFSKALKTADAIPLFPIASLIVLILSIIGQGLIFSLIPTALIVIICIITEFARFVMFLRQVPNNFYTIPSILLRIFVLILLSGAFFAAFYFSPEREYPVFTSIAEKERVSFIADEKEKTAGVYYKPEPCRNEKEAIIIVPPFPNEDAGTFDRYLLNEGYKIASLSLPKKTEYKYKLKNSEIFFSVFDSVFNTKTAETSKKESNENLGTSLSSLIRFFWDTELFLIGEGDQVQDLLDYYNKNPNAFSGAFFIISEGTPLPKGLKEGTYTVLNEKDLKFSENIALFPICIFIQSRESLTGFGDIRGNDILASLLLGSSRDLGRQDRVNKIKAFEKWLNLRASRTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NZ2</accession>
    <name>Q73NZ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flagellar protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971617.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682322.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1008"/>
    <dbReference type="EnsemblBacteria" id="AAS11498">
        <property type="protein sequence ID" value="AAS11498"/>
        <property type="gene ID" value="TDE_1008"/>
    </dbReference>
    <dbReference type="GeneID" id="2740988"/>
    <dbReference type="KEGG" id="tde:TDE_1008"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.968"/>
    <dbReference type="eggNOG" id="COG3951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118623_0_0_12"/>
    <dbReference type="OrthoDB" id="1913134at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019301">
        <property type="entry name" value="Flagellar_prot_FlgJ_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10135">
        <property type="entry name" value="Rod-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rod-binding" evidence="1">
        <location>
            <begin position="146"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="206" mass="22644" checksum="1A84F84121C0DE59" modified="2004-07-05" version="1">MEVNKIGTNQAGREDVKNSLINKSEVPASAKSQQNFTQMLETLRGSERASSIISNIQGESSASVSGLKTGSSEALFDTRLPGDILKSMKIENPVPADTHREVQGIASSFGKSGETVYSRYSIDRTSKLYEQALEFESYFVKIMLDSMRNTLTGKTLAGDESFAGKMYQDMMYDELGRSMTKNAGFGLADQIYLELSGVGEERHFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P14</accession>
    <name>Q73P14_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971595.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671908.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0986"/>
    <dbReference type="EnsemblBacteria" id="AAS11476">
        <property type="protein sequence ID" value="AAS11476"/>
        <property type="gene ID" value="TDE_0986"/>
    </dbReference>
    <dbReference type="GeneID" id="2739063"/>
    <dbReference type="KEGG" id="tde:TDE_0986"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.948"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_12"/>
    <dbReference type="OMA" id="LDPINTI"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS11476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="326" mass="36480" checksum="617C6FD2C19ACAFF" modified="2004-07-05" version="1">MSDELLRVEDLSAGFVTDAGYVEVLDRINFSIKAGQTISLVGESGCGKSVTASSIMRILPHPYGEIRKGRILFEGRNLLDLPIEEMYQIRGSSIAMIFQEPMTALNPVHMVKKQVGEVLELHRPDITKEEMPAHILKYLKDVEIPSAEQRLNNYPFQLSGGMRQRVMIAMALAGHPKLLIADEPTTALDVTVQAQILALIKELQRKNNMGVIYITHDMGVVAEVSDHVAVMYAGQIVETGPVETIFKNPRHPYTRGLIASMPKLDSKPKTRLPYIEGSVPAPRAYPATCRFAERCSYATDYCRANNPVLEEFETDHVIRCFRAREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P87</accession>
    <name>Q73P87_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971522.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0912"/>
    <dbReference type="EnsemblBacteria" id="AAS11403">
        <property type="protein sequence ID" value="AAS11403"/>
        <property type="gene ID" value="TDE_0912"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0912"/>
    <dbReference type="HOGENOM" id="CLU_3391906_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="32" mass="3451" checksum="B45AB93509DDB293" modified="2004-07-05" version="1">MQLAPIDKQLKAVKKIAFYESESTAAKAVTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PC3</accession>
    <name>Q73PC3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971486.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682157.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0876"/>
    <dbReference type="EnsemblBacteria" id="AAS11367">
        <property type="protein sequence ID" value="AAS11367"/>
        <property type="gene ID" value="TDE_0876"/>
    </dbReference>
    <dbReference type="GeneID" id="2740923"/>
    <dbReference type="KEGG" id="tde:TDE_0876"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.846"/>
    <dbReference type="HOGENOM" id="CLU_2921407_0_0_12"/>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="61" mass="7068" checksum="3777A66F83CDF71D" modified="2004-07-05" version="1">MQNGSICQDFIVNLTQKQVSEKVGMKNVYSYQRLEKKSNPSLQMIKKITSIFPAIKLEMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PD2</accession>
    <name>Q73PD2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971477.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956828.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0867"/>
    <dbReference type="EnsemblBacteria" id="AAS11358">
        <property type="protein sequence ID" value="AAS11358"/>
        <property type="gene ID" value="TDE_0867"/>
    </dbReference>
    <dbReference type="GeneID" id="2740914"/>
    <dbReference type="KEGG" id="tde:TDE_0867"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.837"/>
    <dbReference type="eggNOG" id="ENOG502ZIX1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031966_0_0_12"/>
    <dbReference type="OMA" id="RHLEYRT"/>
    <dbReference type="OrthoDB" id="1352468at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="592" mass="68341" checksum="736E823198A4236B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PL5</accession>
    <name>RS5_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsE</name>
        <name type="ordered locus">TDE_0784</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text>The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971394.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670027.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PL5"/>
    <dbReference type="SMR" id="Q73PL5"/>
    <dbReference type="STRING" id="243275.TDE_0784"/>
    <dbReference type="EnsemblBacteria" id="AAS11275">
        <property type="protein sequence ID" value="AAS11275"/>
        <property type="gene ID" value="TDE_0784"/>
    </dbReference>
    <dbReference type="GeneID" id="2740662"/>
    <dbReference type="KEGG" id="tde:TDE_0784"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.757"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_2_2_12"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="OrthoDB" id="1505038at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000131624" description="30S ribosomal protein S5">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="S5 DRBM" evidence="1">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <sequence length="173" mass="18409" checksum="173CD80EB75A67EC" modified="2004-07-05" version="1">MSHQKESKRDNQHTDKEYVEKLVKLNRTAKVVKGGRRFSFSALTVVGDQKGRVGYGFGKANDVSDAIRKSIEKAKANMVTFPLKNGTIPHEVQGKFKGSSVLLRPACSGTGIIAGGTIRAIMEAAGATDLLSKSLGSSSAVNVVKATFDAASLLMDGKKIAKSRGKTLLDVWG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PL7</accession>
    <name>RL6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplF</name>
        <name type="ordered locus">TDE_0782</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971392.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670023.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PL7"/>
    <dbReference type="SMR" id="Q73PL7"/>
    <dbReference type="STRING" id="243275.TDE_0782"/>
    <dbReference type="EnsemblBacteria" id="AAS11273">
        <property type="protein sequence ID" value="AAS11273"/>
        <property type="gene ID" value="TDE_0782"/>
    </dbReference>
    <dbReference type="GeneID" id="2740660"/>
    <dbReference type="KEGG" id="tde:TDE_0782"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.755"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_12"/>
    <dbReference type="OMA" id="KPDPYKG"/>
    <dbReference type="OrthoDB" id="1398618at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000265307" description="50S ribosomal protein L6">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <sequence length="179" mass="19507" checksum="09C586922BBCBAA5" modified="2004-07-05" version="1">MSRVGKMPVAIPAGVKVNVANGIFTVEGPKGKLSQDYHTEAVDFKIEGDHVLVTRKDDELQTRAYHGLYRSLLNNMVTGVSTGFTKTLVINGVGYRAEVQGKLLVMALGYSNDFSVIIPEGIEVKVDQLKVIISGASKEAVGQFASQVRKLRGPEPYKGKGIRYEDEIIKRKVGKSGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PT1</accession>
    <name>Q73PT1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TSPc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971327.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681939.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0715"/>
    <dbReference type="EnsemblBacteria" id="AAS11208">
        <property type="protein sequence ID" value="AAS11208"/>
        <property type="gene ID" value="TDE_0715"/>
    </dbReference>
    <dbReference type="GeneID" id="2740622"/>
    <dbReference type="KEGG" id="tde:TDE_0715"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.692"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040161_0_0_12"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="TSPc" evidence="2">
        <location>
            <begin position="210"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="447" mass="52206" checksum="421CE33164B27CEF" modified="2004-07-05" version="1">MNNLLFIYDIIKIKFRRMIKKINMKKLIISLIIFIFVSVFVVIALNVSKKNDIISGFISAEKMKADYEYFWDFIYKGYPFTEVCERKGADLEQIKQSGYRYLTDPMMQYGYYFFYKDLCRKITGNRYIGHLYPSDYFDYYFNYEKIFKNGAPQTSLIKKRALIDNFYFHIYQVEVLSDKNIGSFNNRNSSLIGTRKYSKPFIQIIETDHIAYIEIKSFLTTKAEEKQEYLKALEDFFIETANYKHIIIDIQNNGGGHPENYEAIISPNINKEINIISYGLYNENKYTNTYLDMFFKNYKSEKINRHEVPYIENCSTVKNDKAYRLEEIIQARPINGYKPCEDKKFWLLVDSGVYSEADRFTYICKKIGFATVVGTNTGGSGTNGKSPMYIVLPNSGLLIKFDFMYGLTEDGYCTDETGTAPDIYNLPGKSALGTCLEEIRKLREKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PU1</accession>
    <name>Q73PU1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPFH domain/Band 7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971317.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669950.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0705"/>
    <dbReference type="EnsemblBacteria" id="AAS11198">
        <property type="protein sequence ID" value="AAS11198"/>
        <property type="gene ID" value="TDE_0705"/>
    </dbReference>
    <dbReference type="GeneID" id="2739827"/>
    <dbReference type="KEGG" id="tde:TDE_0705"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.683"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_2_2_12"/>
    <dbReference type="OMA" id="TQIRAEM"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="Band_7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="17"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="309" mass="34404" checksum="F61336AAAE3CD7BF" modified="2004-07-05" version="1">MIALYVALVVAVIILFSIAVVVPEQESYVIERLGKYSRTLTAGFHILTPFIDRIAYKQNLKEEALDVDPQVCITADNVQVQVDGILYLKIFDPVKASYGIDNYRYAVAQLAKTTMRSEIGKLELDKTFCGREGLNDNIVKALDEASDNWGIKVTRYEIRDITPTRTILEAMERQMRAEREKRANILSSEGKQQSRINISLGKKKEAINKAMGEKQRRINLAEGRSKAIEITSNATAEGLRLIADALSQPGGRTAMGIRLAENYIQRFEHIIKKSNVSVYPENIAGLAAFSDIIKNAGKEVKVIQGGQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q32</accession>
    <name>Q73Q32_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971226.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0612"/>
    <dbReference type="EnsemblBacteria" id="AAS11107">
        <property type="protein sequence ID" value="AAS11107"/>
        <property type="gene ID" value="TDE_0612"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0612"/>
    <dbReference type="HOGENOM" id="CLU_3376599_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="34" mass="4153" checksum="D9493B3A8A0E72BD" modified="2004-07-05" version="1">MTKRGGGGRIKEERKNRSYKFFIWRLFDEKTGFI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-29" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q47</accession>
    <name>FABV_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trans-2-enoyl-CoA reductase [NADH]</fullName>
            <shortName evidence="6">TER</shortName>
            <ecNumber evidence="2 4 5">1.3.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fabV</name>
        <name type="ordered locus">TDE_0597</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="FEBS Lett." volume="581" first="1561" last="1566">
            <title>A novel prokaryotic trans-2-enoyl-CoA reductase from the spirochete Treponema denticola.</title>
            <authorList>
                <person name="Tucci S."/>
                <person name="Martin W."/>
            </authorList>
            <dbReference type="PubMed" id="17382934"/>
            <dbReference type="DOI" id="10.1016/j.febslet.2007.03.013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBUNIT</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2011" name="Nat. Chem. Biol." volume="7" first="222" last="227">
            <title>Enzyme mechanism as a kinetic control element for designing synthetic biofuel pathways.</title>
            <authorList>
                <person name="Bond-Watts B.B."/>
                <person name="Bellerose R.J."/>
                <person name="Chang M.C."/>
            </authorList>
            <dbReference type="PubMed" id="21358636"/>
            <dbReference type="DOI" id="10.1038/nchembio.537"/>
        </citation>
        <scope>BIOTECHNOLOGY</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2012" name="Biochemistry" volume="51" first="6827" last="6837">
            <title>Biochemical and structural characterization of the trans-enoyl-CoA reductase from Treponema denticola.</title>
            <authorList>
                <person name="Bond-Watts B.B."/>
                <person name="Weeks A.M."/>
                <person name="Chang M.C."/>
            </authorList>
            <dbReference type="PubMed" id="22906002"/>
            <dbReference type="DOI" id="10.1021/bi300879n"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>MUTAGENESIS OF TYR-240; LEU-276; VAL-277; ILE-287; LEU-291; PHE-295 AND TYR-370</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>SUBSTRATE SPECIFICITY</scope>
        <scope>SUBUNIT</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2013" name="Biochem. J." volume="449" first="79" last="89">
            <title>Structures of trans-2-enoyl-CoA reductases from Clostridium acetobutylicum and Treponema denticola: insights into the substrate specificity and the catalytic mechanism.</title>
            <authorList>
                <person name="Hu K."/>
                <person name="Zhao M."/>
                <person name="Zhang T."/>
                <person name="Zha M."/>
                <person name="Zhong C."/>
                <person name="Jiang Y."/>
                <person name="Ding J."/>
            </authorList>
            <dbReference type="PubMed" id="23050861"/>
            <dbReference type="DOI" id="10.1042/BJ20120871"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.02 ANGSTROMS) IN COMPLEX WITH NAD</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBUNIT</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4 5">Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of the carbon-carbon double bond of crotonyl-CoA to yield butyryl-CoA. In vitro it can also use hexenoyl-CoA and dodecenoyl-CoA as substrates (PubMed:22906002).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 4 5">
            <text>a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:18177"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.1.44"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="4">Inhibited by lauroyl-CoA.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">2.7 uM for crotonyl-CoA (at pH 6.2 and 30 degrees Celsius)</KM>
            <KM evidence="4">5.2 uM for NAD</KM>
            <KM evidence="4">12 uM for dodecenoyl-CoA</KM>
            <KM evidence="4">12 uM for hexenoyl-CoA</KM>
            <KM evidence="5">69.7 uM for NAD (at pH 6.2 and 25 degrees Celsius)</KM>
            <KM evidence="4">70 uM for crotonyl-CoA</KM>
            <KM evidence="4">190 uM for NADP</KM>
            <text evidence="4 5">kcat is 385.9 sec(-1) for reductase activity (at pH 6.2 and 25 degrees Celsius) (PubMed:23050861). kcat is 112 sec(-1) for reductase activity with hexenoyl-CoA as substrate (PubMed:22906002). kcat is 91 sec(-1) for reductase activity with crotonyl-CoA as substrate (PubMed:22906002). kcat is 90 sec(-1) for reductase activity with dodecenoyl-CoA as substrate (PubMed:22906002).</text>
        </kinetics>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4 5">Monomer.</text>
    </comment>
    <comment type="biotechnology">
        <text evidence="3">Used in the biosynthesis of medium-chain volatile alcohols as biofuels engineered by microorganisms. The switch from the native flavin-dependent enoyl-CoA reductase used in the production of n-butanol, a key second-generation biofuel, to a flavin-independent trans-enoyl-CoA reductase from T.denticola leads to an order of magnitude increase in product yield in engineered E.coli.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">Possesses high activity for the reduction reaction, but no activity for the reverse oxidation reaction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TER reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.44" evidence="2 4 5"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971211.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681770.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="PDB" id="4FBG">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.02 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P=1-397"/>
    </dbReference>
    <dbReference type="PDB" id="4GGO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B/C/D=1-397"/>
    </dbReference>
    <dbReference type="PDB" id="4GGP">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.05 A"/>
        <property type="chains" value="A/B/C/D=1-397"/>
    </dbReference>
    <dbReference type="PDBsum" id="4FBG"/>
    <dbReference type="PDBsum" id="4GGO"/>
    <dbReference type="PDBsum" id="4GGP"/>
    <dbReference type="AlphaFoldDB" id="Q73Q47"/>
    <dbReference type="SMR" id="Q73Q47"/>
    <dbReference type="STRING" id="243275.TDE_0597"/>
    <dbReference type="EnsemblBacteria" id="AAS11092">
        <property type="protein sequence ID" value="AAS11092"/>
        <property type="gene ID" value="TDE_0597"/>
    </dbReference>
    <dbReference type="GeneID" id="2741560"/>
    <dbReference type="KEGG" id="tde:TDE_0597"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.577"/>
    <dbReference type="eggNOG" id="COG3007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057698_1_0_12"/>
    <dbReference type="OMA" id="EGCIEQI"/>
    <dbReference type="OrthoDB" id="678530at2"/>
    <dbReference type="BRENDA" id="1.3.1.44">
        <property type="organism ID" value="6426"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050343">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01838">
        <property type="entry name" value="FabV_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024906">
        <property type="entry name" value="Eno_Rdtase_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024910">
        <property type="entry name" value="Enoyl-CoA_Rdtase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010758">
        <property type="entry name" value="Trans-2-enoyl-CoA_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37480">
        <property type="entry name" value="PTHR37480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07055">
        <property type="entry name" value="Eno-Rase_FAD_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12242">
        <property type="entry name" value="Eno-Rase_NADH_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12241">
        <property type="entry name" value="Enoyl_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000220050" description="Trans-2-enoyl-CoA reductase [NADH]">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1 8 9">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="53"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="144"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="276"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Plays an important role in discriminating NADH against NADPH" evidence="5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Loss of reductase activity, but no significant change in the affinity for crotonyl-CoA." evidence="4">
        <original>Y</original>
        <variation>F</variation>
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Significant decrease of the catalytic efficiency; when associated with A-277. The catalytic efficiency is slightly reduces and the affinity is relatively similar to wild-type; when associated with A-277 and A-295." evidence="4">
        <original>L</original>
        <variation>A</variation>
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Significant decrease of the catalytic efficiency; when associated with A-276. The catalytic efficiency is slightly reduces and the affinity is relatively similar to wild-type; when associated with A-276 and A-295." evidence="4">
        <original>V</original>
        <variation>A</variation>
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Shows 7-, 13- and 15-fold decrease of catalytic efficiency of the reductase activity for hexenoyl-CoA, crotonyl-CoA and dodecenoyl-CoA, respectively. The affinity is relatively similar to wild-type. This mutation may increase the accessibility of the longer acyl chain to the active site pocket." evidence="4">
        <original>I</original>
        <variation>A</variation>
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="The catalytic efficiency and affinity are relatively similar to wild-type toward crotonyl-CoA and hexenoyl-CoA." evidence="4">
        <original>L</original>
        <variation>A</variation>
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="The catalytic efficiency and affinity are relatively similar to wild-type toward crotonyl-CoA and hexenoyl-CoA. The catalytic efficiency is slightly reduces and the affinity is relatively similar to wild-type; when associated with A-276 and A-277." evidence="4">
        <original>F</original>
        <variation>A</variation>
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="The catalytic efficiency and affinity are relatively similar to wild-type toward crotonyl-CoA and hexenoyl-CoA." evidence="4">
        <original>Y</original>
        <variation>A</variation>
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="37"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="strand" evidence="10">
        <location>
            <begin position="41"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="48"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="73"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="turn" evidence="11">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="turn" evidence="11">
        <location>
            <begin position="176"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="181"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="237"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="266"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="281"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="284"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="334"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="turn" evidence="11">
        <location>
            <begin position="338"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="turn" evidence="11">
        <location>
            <begin position="358"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="361"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="helix" evidence="11">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="turn" evidence="11">
        <location>
            <begin position="377"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="strand" evidence="11">
        <location>
            <begin position="387"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="17382934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="21358636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22906002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="23050861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="23050861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <evidence type="ECO:0000305" key="8">
        <source>
            <dbReference type="PubMed" id="22906002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9">
        <source>
            <dbReference type="PubMed" id="23050861"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="4FBG"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="4GGO"/>
        </source>
    </evidence>
    <sequence length="397" mass="43759" checksum="7D5916140E5A8F35" modified="2004-07-05" version="1">MIVKPMVRNNICLNAHPQGCKKGVEDQIEYTKKRITAEVKAGAKAPKNVLVLGCSNGYGLASRITAAFGYGAATIGVSFEKAGSETKYGTPGWYNNLAFDEAAKREGLYSVTIDGDAFSDEIKAQVIEEAKKKGIKFDLIVYSLASPVRTDPDTGIMHKSVLKPFGKTFTGKTVDPFTGELKEISAEPANDEEAAATVKVMGGEDWERWIKQLSKEGLLEEGCITLAYSYIGPEATQALYRKGTIGKAKEHLEATAHRLNKENPSIRAFVSVNKGLVTRASAVIPVIPLYLASLFKVMKEKGNHEGCIEQITRLYAERLYRKDGTIPVDEENRIRIDDWELEEDVQKAVSALMEKVTGENAESLTDLAGYRHDFLASNGFDVEGINYEAEVERFDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q64</accession>
    <name>Q73Q64_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971194.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681746.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0580"/>
    <dbReference type="EnsemblBacteria" id="AAS11075">
        <property type="protein sequence ID" value="AAS11075"/>
        <property type="gene ID" value="TDE_0580"/>
    </dbReference>
    <dbReference type="GeneID" id="2741016"/>
    <dbReference type="KEGG" id="tde:TDE_0580"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.561"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_604004_0_0_12"/>
    <dbReference type="OrthoDB" id="1925247at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="198"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="432" mass="50557" checksum="2F99B560D6077BA3" modified="2004-07-05" version="1">MKVFKFTVSGTIYIIFSILLLTGAAIRGELFAIVCGVCLCLYVVLSLIFISLSVLLWKKTDLLVELKNENISILPSRVRKGKKLFSIILPGVIVFYGFEFLSDLKNKKSRSLKFNIKLKRFAAHFPLPKEERGRFFLEKEYIEISDLAGFFSFRLLKKEKSIPQLFIYPMLTEIKSFAIPEILNETSAHTINLRRTDELYDSRPYFPGDDIRKLNWKLYAHTQELSIKQGDFVPPPRSFFTIYVESPIVNNDIEFYKKKFDEFINLSTSIAFYLHQKGISFNIRFYDNEKNSYETGSVYSDDRDVEESIKRFFSIPQIRVQKKSSEAEPKLKRNFFIDGENKKTCLLYFFMPVQSSKKILDKLFGIFSDHKKECVFYTGPESIIIEPKNILHSFLFYTSSQKKYNRLSKEMNEKIEILKHELKTGGFYAYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q70</accession>
    <name>Q73Q70_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971187.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0573"/>
    <dbReference type="EnsemblBacteria" id="AAS11068">
        <property type="protein sequence ID" value="AAS11068"/>
        <property type="gene ID" value="TDE_0573"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0573"/>
    <dbReference type="HOGENOM" id="CLU_3141866_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="49" mass="5530" checksum="366D41878C94F022" modified="2004-07-05" version="1">MGNFPITNYKLKNRLECGESSGSGRFFIRRGHADTCLRAGTLRKTCRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q77</accession>
    <name>Q73Q77_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971180.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681735.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0566"/>
    <dbReference type="EnsemblBacteria" id="AAS11061">
        <property type="protein sequence ID" value="AAS11061"/>
        <property type="gene ID" value="TDE_0566"/>
    </dbReference>
    <dbReference type="GeneID" id="2741002"/>
    <dbReference type="KEGG" id="tde:TDE_0566"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.550"/>
    <dbReference type="eggNOG" id="ENOG5031D5Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1214339_0_0_12"/>
    <dbReference type="OrthoDB" id="1418589at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="223" mass="25689" checksum="F030A317F82BC93F" modified="2004-07-05" version="1">MKQIPDFLRENDRYYIYALQALKQLFTETSCTWRKWIETDIEEYLSTGSVEHHLGAYGGMGSINDIWICKVNNHTINDEAEPWANELMEYFKCLSYGIANIIKAGKKINIEKIFAESRTRKILTGIQCESCGFSQIHKRETDSYLASILLPKMVKEAVLQNKTEELISACLIPDIPNLVEERERIIKLAEQSGIGFSVSKNYCCKKCGGDTRIRYWKLDGKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q78</accession>
    <name>Q73Q78_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971179.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0565"/>
    <dbReference type="EnsemblBacteria" id="AAS11060">
        <property type="protein sequence ID" value="AAS11060"/>
        <property type="gene ID" value="TDE_0565"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0565"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.549"/>
    <dbReference type="HOGENOM" id="CLU_3318658_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="39" mass="4183" checksum="D9025D445D74F5CE" modified="2004-07-05" version="1">MGMGQISRYLGRPVARIIGFAGSIFFAVVGGIFVYGVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q87</accession>
    <name>Q73Q87_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971170.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681725.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0556"/>
    <dbReference type="EnsemblBacteria" id="AAS11051">
        <property type="protein sequence ID" value="AAS11051"/>
        <property type="gene ID" value="TDE_0556"/>
    </dbReference>
    <dbReference type="GeneID" id="2739801"/>
    <dbReference type="KEGG" id="tde:TDE_0556"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.541"/>
    <dbReference type="eggNOG" id="ENOG502Z9WB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125388_0_0_12"/>
    <dbReference type="OrthoDB" id="1175589at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="184" mass="21378" checksum="259341C22C37EB1C" modified="2004-07-05" version="1">MARYELGAIYEIDAGKKSYYARLLNCDLYGVFAPLSGEISEEAFENTPYRLYISTGSYAVKRGFWKKLFPSPDKTDIERWSRPLHLVVFTPWDIEGALNRRTSFDKYGHTEILDEKTYIQFLKQGFISIIQPMYEKVPQFLNNYYDDWPASEIYSDVLTGAGTAEHQQKQMSSLKKIGFDVSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q89</accession>
    <name>Q73Q89_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971168.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681720.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0554"/>
    <dbReference type="EnsemblBacteria" id="AAS11049">
        <property type="protein sequence ID" value="AAS11049"/>
        <property type="gene ID" value="TDE_0554"/>
    </dbReference>
    <dbReference type="GeneID" id="2739799"/>
    <dbReference type="KEGG" id="tde:TDE_0554"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.539"/>
    <dbReference type="eggNOG" id="ENOG5032N34">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1314910_0_0_12"/>
    <dbReference type="OrthoDB" id="1006709at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="209" mass="24520" checksum="866D4E2AC1C6263C" modified="2004-07-05" version="1">MHYIGELTTDGYGMAIIPIDLLTGYLASKKCRAKKLLSYLQKNFELFPELVEKGKLVPFYRINSFDYHIFASINEEAVIPEGFKEVCRFEKFYLEVGDLNKICFSCFDDLDYDFENIKKNITEHTEYIKTGPKDIMEPYNYRLGFDIPKGKYEFDLIGLEKIEKTERESKNYGYAFVFKKNENAVNNNVTKCDNEDGTYKFNVPREKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QA2</accession>
    <name>Q73QA2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971155.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0541"/>
    <dbReference type="EnsemblBacteria" id="AAS11036">
        <property type="protein sequence ID" value="AAS11036"/>
        <property type="gene ID" value="TDE_0541"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0541"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.527"/>
    <dbReference type="eggNOG" id="COG5620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128144_0_0_12"/>
    <dbReference type="OrthoDB" id="24813at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="107" mass="12387" checksum="843623C6C777474A" modified="2004-07-05" version="1">MIMQKKEIDPDDYYDKMIPEVKSWFQQLEIPAELAPKVTQLFLDGGNEINMQLIPQWDGEDNLFDIKSISDEELAQFPNLKLIDGTVIYISEKTKKKLIEKGINIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QD4</accession>
    <name>Q73QD4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971123.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681641.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0509"/>
    <dbReference type="EnsemblBacteria" id="AAS11004">
        <property type="protein sequence ID" value="AAS11004"/>
        <property type="gene ID" value="TDE_0509"/>
    </dbReference>
    <dbReference type="GeneID" id="2739606"/>
    <dbReference type="KEGG" id="tde:TDE_0509"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.495"/>
    <dbReference type="eggNOG" id="ENOG502Z945">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432838_0_0_12"/>
    <dbReference type="OrthoDB" id="1152169at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="189" mass="22093" checksum="BB1F9F9954977DB9" modified="2004-07-05" version="1">MNEIEKYRILSAGKAFGHRAQIALLLLDSSTAYEELKEEAAQTSVAGSYGCAGGFPSEILERIIIELICRDTRNTWYLPDNVKFWDRRFGSLFETKFFCYDDEVETWSKILYKFFVKLKWMPKREDYTSTKSYNNVWGYFAELLAVVKQNNHPEFDKYYEIAIKNGMDPAVLEKKLKELSEIKQSFIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QD6</accession>
    <name>Q73QD6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971121.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681636.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0507"/>
    <dbReference type="EnsemblBacteria" id="AAS11002">
        <property type="protein sequence ID" value="AAS11002"/>
        <property type="gene ID" value="TDE_0507"/>
    </dbReference>
    <dbReference type="GeneID" id="2739604"/>
    <dbReference type="KEGG" id="tde:TDE_0507"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.493"/>
    <dbReference type="eggNOG" id="ENOG503318R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190514_0_0_12"/>
    <dbReference type="OrthoDB" id="1953335at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="69" mass="7986" checksum="EF94F5C5DAA2ED66" modified="2004-07-05" version="1">MSTYIIKEKTLVTLKDEISLEYPFSDDMPMVYLGEIANMPEHGIFIGQSGKCYFGYHISNFRELSEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QE9</accession>
    <name>Q73QE9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HipA_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971108.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681613.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0494"/>
    <dbReference type="EnsemblBacteria" id="AAS10989">
        <property type="protein sequence ID" value="AAS10989"/>
        <property type="gene ID" value="TDE_0494"/>
    </dbReference>
    <dbReference type="GeneID" id="2738979"/>
    <dbReference type="KEGG" id="tde:TDE_0494"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.479"/>
    <dbReference type="eggNOG" id="COG3550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070311_0_0_12"/>
    <dbReference type="OMA" id="EQYVSYE"/>
    <dbReference type="OrthoDB" id="1293681at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012893">
        <property type="entry name" value="HipA-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07804">
        <property type="entry name" value="HipA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HipA_C" evidence="2">
        <location>
            <begin position="56"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="318" mass="36080" checksum="CA15D4C6648E55E1" modified="2004-07-05" version="1">MNCLCCGKPIKDNNESSGWHKTCIKKFFTTAVIPEIEITDSVLEELAKESTNKGYTIPGVQKKLSLHLSKEVYPRLTVVNYPTGYILKPQVKEFRALPEAEHLVMSMADKAKIRTVPHALVKSKDSYAYITKRIDRVFSKDSNVKLIAMEDFCQLDLRLTQDKYKGSCERCGNIIKKYSSRSGLDMSELFYRLVFSFIVGNSDMHLKNFSLIESESGSGEYHLSPAYDLLPVNVIIPEDKEEFALPINGKKRNIHRKDFLIFAAGCGIAKLAAEKMIGQLIFMEPVFIDMCCNSLMPQDMKEAFIELVDKRVSALMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QF2</accession>
    <name>Q73QF2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971105.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0491"/>
    <dbReference type="EnsemblBacteria" id="AAS10986">
        <property type="protein sequence ID" value="AAS10986"/>
        <property type="gene ID" value="TDE_0491"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0491"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.476"/>
    <dbReference type="eggNOG" id="ENOG5031CP0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097188_0_0_12"/>
    <dbReference type="OrthoDB" id="2120221at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="250" mass="29696" checksum="DD48D7D577C2E994" modified="2004-07-05" version="1">MLFFQYLYSSVCSLKIDTVTLTVRSKYTDFFYLYHERWLVKRLKNFNLKLRHKTAKILYNMFMEKNRKRIVFIAAALIYFMLYAAAFAEKHDDDCKTLRYRGKRLPSAVELFYVTKIESEIESGNYLEIEIKFNIPVEPRTLQKKFIRINGNPLPGAAVLSFNKAGNKIKILIPVSVVLGSEKDEPFYIDLPEAKSFNHIPLYSSHFDDIHCNKEYRFEFVNIHPHKDKEKHGKITHNHYSEYLRFEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QJ0</accession>
    <name>Q73QJ0_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1902 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971067.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666045.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0453"/>
    <dbReference type="EnsemblBacteria" id="AAS10948">
        <property type="protein sequence ID" value="AAS10948"/>
        <property type="gene ID" value="TDE_0453"/>
    </dbReference>
    <dbReference type="GeneID" id="2740750"/>
    <dbReference type="KEGG" id="tde:TDE_0453"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.440"/>
    <dbReference type="eggNOG" id="ENOG5033E6G">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_175518_4_0_12"/>
    <dbReference type="OrthoDB" id="2063069at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015066">
        <property type="entry name" value="DUF1902"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08972">
        <property type="entry name" value="DUF1902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1902" evidence="1">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="73" mass="8424" checksum="9385BB4BEA1297C8" modified="2004-07-05" version="1">MEYIIKINWDNEAGVWIATSDDIRGLVLESGSIDALMERVRYAVPDLLQENNQIPHNQTTLHFCAEKSERMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QK4</accession>
    <name>Q73QK4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971053.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681513.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0439"/>
    <dbReference type="EnsemblBacteria" id="AAS10934">
        <property type="protein sequence ID" value="AAS10934"/>
        <property type="gene ID" value="TDE_0439"/>
    </dbReference>
    <dbReference type="GeneID" id="2740585"/>
    <dbReference type="KEGG" id="tde:TDE_0439"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.426"/>
    <dbReference type="eggNOG" id="ENOG5031CYI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1184613_0_0_12"/>
    <dbReference type="OrthoDB" id="2143408at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024471">
        <property type="entry name" value="DUF2715"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10895">
        <property type="entry name" value="DUF2715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004286041" evidence="1">
        <location>
            <begin position="21"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="239" mass="26125" checksum="27B8770BB850E095" modified="2004-07-05" version="1">MKKMIIVFFCMLFISVNSFAEFVISPTLGASNVFSTDVFPPTVYIGGLSHKEKSSLSWTPMNFGILLGTVKEKGFTFLFSVDALFIGNVNANYKEFVRDTEVLNFKAKAKIGGGAVAQGNFLFGYTYKGVPNLYLTFASGLTLGGGVNTIKEISTSGITVPNINVSLKTANFGIPLYFSASYYFTDKIGINVSFLNSFCAGWQWYNDKSPLPYLGTGYGPETPAFVNVFTFKIGPTFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QQ4</accession>
    <name>Q73QQ4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(R)-2-hydroxyglutaryl-CoA dehydratase, beta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971003.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0389"/>
    <dbReference type="EnsemblBacteria" id="AAS10884">
        <property type="protein sequence ID" value="AAS10884"/>
        <property type="gene ID" value="TDE_0389"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0389"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.378"/>
    <dbReference type="eggNOG" id="COG1775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053697_1_1_12"/>
    <dbReference type="OMA" id="RICPYFQ"/>
    <dbReference type="OrthoDB" id="1815612at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="412" mass="46466" checksum="FC46D77255B980D7" modified="2004-07-05" version="1">MDVKTHDLLCEALPGAFGDVYLAQENRPEGMDFFNMVVADIHGIRPQELVDFQKEGGKVVGSFCIHVPDEVVIAAGAIATGLCSGSQFWVPDGEKFLPTATCPLIKASLGARFGKTCPFFRICDLFVGETTCDGKKKAWEILAEDAPMHIMDIPQMKRPQDFEKWACEIKGYIKKLEELTGNTVTPESLKKAIEIVNNKRKALQRLNNFRKLENIPISGKDVLLIHQIAFYDDPTRFVTMVNKLCDELETRKKQNVSVFKKGTKRILLTGTPLSIPNWKIHHIIETTGGAVVCEEMCTGIRYCEALVDETGTTIDEMVNNLTKRYLGHINCACFTPNKERIDDIIRLAKEYKADGVIDLNLKFCNIYDTEGYFVEKVLREHNIPCLGIETDYTDEDAEQLKTRIGAFIEMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QS3</accession>
    <name>Q73QS3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="9">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">murD</name>
        <name evidence="11" type="ordered locus">TDE_0370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="9"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970984.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956725.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0370"/>
    <dbReference type="EnsemblBacteria" id="AAS10865">
        <property type="protein sequence ID" value="AAS10865"/>
        <property type="gene ID" value="TDE_0370"/>
    </dbReference>
    <dbReference type="GeneID" id="2740122"/>
    <dbReference type="KEGG" id="tde:TDE_0370"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.360"/>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032540_0_1_12"/>
    <dbReference type="OMA" id="CNFENYL"/>
    <dbReference type="OrthoDB" id="1093223at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="118"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="120"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS10865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="476" mass="53163" checksum="4734DA01E6BC8B77" modified="2004-07-05" version="1">MQISLENIKNKKVTVMGLGLNGGGLATAQFFARYGAEVTVTDLKTSEELRPSIEKLSSFKNIRFVLGEHRIEDFREADLVIKNPGVKLEGNVFLEAAKQIESDVSVFLSLSKAPILAVTGSKGKSSTVSALYYGLKKLGYNAFLGGNITVSPLSFFEETSCDTPVVLELSSWQLADLKNKKLLKPKIAIITPIMPDHLNWYGTMEKYVADKKIIYENMDEADYLICNFDDGWGKIFAEETRANVFWYSEKKPAKKYRGVFFNKNQEGLCNLSDGERLLLSKDAKVPGLKLKQNVLNAGLALLLYQKIHKPENLKDNNIKEQSEFIRKFMDEYSGIEHRLEFFYEKNGIKFYNDTAATIPEASAAALEAFDKPPVLICGGTNKNLNFIPLAEKANLAKSLYLLAGTGTDLLIPLLKEKSIEYNGPFDSLDSLLLLLKENAEKGDVVILSPGAASFGMFKNEFDRGNKFKEKVKEIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QU9</accession>
    <name>Q73QU9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970958.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681321.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0344"/>
    <dbReference type="EnsemblBacteria" id="AAS10839">
        <property type="protein sequence ID" value="AAS10839"/>
        <property type="gene ID" value="TDE_0344"/>
    </dbReference>
    <dbReference type="GeneID" id="2741240"/>
    <dbReference type="KEGG" id="tde:TDE_0344"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.333"/>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_4_3_12"/>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="14"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="73" mass="8007" checksum="A70313D2C6C28C95" modified="2004-07-05" version="1">MRSKKDGKLHAWTAKVGTKGQIVIPKEARKIFSIETGDDLLILGDERRGVAIMKGDAATKILMSIQGELIDEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QV3</accession>
    <name>ALF1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fructose-bisphosphate aldolase class 1</fullName>
            <ecNumber evidence="1">4.1.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Fructose-bisphosphate aldolase class I</fullName>
            <shortName evidence="1">FBP aldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fda</name>
        <name type="ordered locus">TDE_0340</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970954.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681313.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73QV3"/>
    <dbReference type="SMR" id="Q73QV3"/>
    <dbReference type="STRING" id="243275.TDE_0340"/>
    <dbReference type="EnsemblBacteria" id="AAS10835">
        <property type="protein sequence ID" value="AAS10835"/>
        <property type="gene ID" value="TDE_0340"/>
    </dbReference>
    <dbReference type="GeneID" id="2739339"/>
    <dbReference type="KEGG" id="tde:TDE_0340"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.329"/>
    <dbReference type="eggNOG" id="COG3588">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081560_0_0_12"/>
    <dbReference type="OMA" id="GVFGTKM"/>
    <dbReference type="OrthoDB" id="945470at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00949">
        <property type="entry name" value="FBP_aldolase_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00729">
        <property type="entry name" value="FBP_aldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023014">
        <property type="entry name" value="FBA_I_Gram+-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="PTHR11627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_0000216914" description="Fructose-bisphosphate aldolase class 1">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with dihydroxyacetone-P" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00729"/>
        </source>
    </evidence>
    <sequence length="295" mass="32805" checksum="5C1A6403A7D4EA20" modified="2004-07-05" version="1">MDKVKLERMKNDKGFIAALDQSGGSTPKALAAYGVPETAYSNEKEMFDLVHAMRTRIITGKAFNSNNILGAILFEQTMEREIEGMPTADFLWEKKKILPFLKVDKGLADLKDGVQLMKPIPNLDAMLKHAVEKHIFGTKMRSVIKEANPKGIKAVVDQQFELGIQIAKAGLVPIIEPEVDIKSPDKAKCEEILKKELEEHLKTLPKDLLVMFKLSIPTKENLYEEFTKHPQVVRVVALSGGYSRDDANKLLAKNRGMIASFSRALAEGLFASQSDAEFNATLEKTIKGVYEASIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QV9</accession>
    <name>Q73QV9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970948.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681300.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0334"/>
    <dbReference type="EnsemblBacteria" id="AAS10829">
        <property type="protein sequence ID" value="AAS10829"/>
        <property type="gene ID" value="TDE_0334"/>
    </dbReference>
    <dbReference type="GeneID" id="2741550"/>
    <dbReference type="KEGG" id="tde:TDE_0334"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.323"/>
    <dbReference type="HOGENOM" id="CLU_1110999_0_0_12"/>
    <dbReference type="OrthoDB" id="1155102at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="250" mass="28172" checksum="82E1927611E5FEA8" modified="2004-07-05" version="1">MFFVSLITVIITVSTFALVARILIAYWIYKDSQERDDEPLIWVLIVFFLSAVLGLVLYLVAARKSKRIKCTSCGFIQAAGIPFCGSCGKQMPHLSDAVNKRNKANLWPLIAAAVLTLLNLIFSIILSIYIFKSAINDEIKNFFPNTNIAIMQTQTNFNNLWKAKFKYKTSENITTFTIKEGKDLKCLWNIDSGNISVEISFGDKLITSFDNNKDGNILNTEIDMSAYTDKKIKLKIKCSKASGSFEFNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QW6</accession>
    <name>Q73QW6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas9</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas9</name>
        <name evidence="11" type="ordered locus">TDE_0327</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer; Cas9 is inactive in the absence of the 2 guide RNAs (gRNA). Cas9 recognizes the protospacer adjacent motif (PAM) in the CRISPR repeat sequences to help distinguish self versus nonself, as targets within the bacterial CRISPR locus do not have PAMs. PAM recognition is also required for catalytic activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer. Binds crRNA and tracrRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Has 2 endonuclease domains. The discontinuous RuvC-like domain cleaves the target DNA noncomplementary to crRNA while the HNH nuclease domain cleaves the target DNA complementary to crRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated Cas9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970941.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681289.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73QW6"/>
    <dbReference type="STRING" id="243275.TDE_0327"/>
    <dbReference type="EnsemblBacteria" id="AAS10822">
        <property type="protein sequence ID" value="AAS10822"/>
        <property type="gene ID" value="TDE_0327"/>
    </dbReference>
    <dbReference type="GeneID" id="2741543"/>
    <dbReference type="KEGG" id="tde:TDE_0327"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.316"/>
    <dbReference type="eggNOG" id="COG3513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005604_0_0_12"/>
    <dbReference type="OrthoDB" id="27691at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01480">
        <property type="entry name" value="Cas9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028629">
        <property type="entry name" value="Cas9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032239">
        <property type="entry name" value="Cas9-BH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032237">
        <property type="entry name" value="Cas9_PI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032240">
        <property type="entry name" value="Cas9_REC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033114">
        <property type="entry name" value="HNH_CAS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16593">
        <property type="entry name" value="Cas9-BH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16595">
        <property type="entry name" value="Cas9_PI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16592">
        <property type="entry name" value="Cas9_REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13395">
        <property type="entry name" value="HNH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01865">
        <property type="entry name" value="cas_Csn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51749">
        <property type="entry name" value="HNH_CAS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HNH Cas9-type" evidence="10">
        <location>
            <begin position="801"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="active site" description="For RuvC-like nuclease domain" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor for HNH nuclease domain" evidence="8">
        <location>
            <position position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS10822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1395" mass="161960" checksum="96813F0F858DD869" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QX2</accession>
    <name>Q73QX2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">TDE_0321</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970935.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681281.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0321"/>
    <dbReference type="EnsemblBacteria" id="AAS10816">
        <property type="protein sequence ID" value="AAS10816"/>
        <property type="gene ID" value="TDE_0321"/>
    </dbReference>
    <dbReference type="GeneID" id="2739328"/>
    <dbReference type="KEGG" id="tde:TDE_0321"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.310"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_12"/>
    <dbReference type="OMA" id="EHTMVRN"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="3"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="210"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="282"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAS10816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="439" mass="49439" checksum="69D54458EE56E889" modified="2004-07-05" version="1">MNEPPPQWFYILLLIVLLFLSMMFSSGETAFLSVNKLKIKYLREKKNKKAARVEKILKDKQKFLTTSLIGNSLVNILISVLLTALMVELVGAKGLSIAVTAATIAILIFGEILPKSIALVFSEPIALKFSGFILFLIKVLAPLEWLFSGFTKFFLKFLGVKNLQSNEALTDADLKDFFDVSQEHGDLRSEEKAVLEKILSYGDITVKNIMTPRPDIIGLTADVNPEEIIELSHSSRFSRFPVYEEDIDEIIGIFYIKDFLFSEAAAKDFLQESKEKFDIKKYLRKPVLVFENTELSKLQEIFRKEKQNMVVVIDEYGGTLGIATLEDLNEEIFGNIADEYDTDDAAAEDPNLDNINDEETQNLSQTILGSMRLSDLNENLGTSFSSEYYDTIGGLIMEKCGEVPQIGSTIKIENYNFTVMKTEGNRISELQVNIAGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R34</accession>
    <name>Q73R34_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methlytransferase, UbiE/COQ5 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970873.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681186.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0258"/>
    <dbReference type="EnsemblBacteria" id="AAS10754">
        <property type="protein sequence ID" value="AAS10754"/>
        <property type="gene ID" value="TDE_0258"/>
    </dbReference>
    <dbReference type="GeneID" id="2739683"/>
    <dbReference type="KEGG" id="tde:TDE_0258"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.253"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_4_0_12"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="49"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="250" mass="29353" checksum="293AF9F60EA259EE" modified="2004-07-05" version="1">MDIKDLMKKWSEQAENMRMFHMQELKENGSEWKKLLQENLKDCKGKKVLDAGCGTGFLAILLAQDGWEVTAIDSSEAMLEEGKKTAEELGLSDKITFLLKDAHSTDFPEHLFDAVVSRHASWLFTAPETVYKEWKRILKPGGIMLNIDANWLKPIWNTDEFEKFKSYEAELVKQYGEFRDYYHDEQMINILKKFPLAYINRPEWDEKMLKKIDFKEIASRLLSKEKYMDAFQAARYKTIPMFVIKAKNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R71</accession>
    <name>Q73R71_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970836.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681122.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0220"/>
    <dbReference type="EnsemblBacteria" id="AAS10717">
        <property type="protein sequence ID" value="AAS10717"/>
        <property type="gene ID" value="TDE_0220"/>
    </dbReference>
    <dbReference type="GeneID" id="2741126"/>
    <dbReference type="KEGG" id="tde:TDE_0220"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.213"/>
    <dbReference type="HOGENOM" id="CLU_3190260_0_0_12"/>
    <dbReference type="OrthoDB" id="2050366at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012869">
        <property type="entry name" value="RHH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07878">
        <property type="entry name" value="RHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_5" evidence="1">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="46" mass="5356" checksum="3EADD7959769B5C0" modified="2004-07-05" version="1">MPLLQVRECPEDIYRKITYAAKSENRTIAQQIIVLLEKALRQIVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R89</accession>
    <name>Q73R89_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970818.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681099.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0202"/>
    <dbReference type="EnsemblBacteria" id="AAS10699">
        <property type="protein sequence ID" value="AAS10699"/>
        <property type="gene ID" value="TDE_0202"/>
    </dbReference>
    <dbReference type="GeneID" id="2739018"/>
    <dbReference type="KEGG" id="tde:TDE_0202"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.197"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796785_0_0_12"/>
    <dbReference type="OMA" id="HCADGFG"/>
    <dbReference type="OrthoDB" id="1644627at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285035" evidence="1">
        <location>
            <begin position="25"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="340" mass="39134" checksum="B979CB93FE85481C" modified="2004-07-05" version="1">MKTSRIKFAVRLMFFLFCVSAVFSESGDIKQNIPVTSMPPKWEPLFPSALWVKNIPIKQEVLIQTVKTKEEMDASLKFDESKLQSVLLNNDIFALYGKPGAYTMGILGRYSPEEIEPIMNEFIITYDEVNKERGIIPAFYLIYGTCWPEGEIGLLRLSTVKKYIEFAAERGWYVFIDHQIGKYTVEQAMNAILPFLKYPNVHLALDPEWRTTQPMRVIGSVTGDEINKAQEMMDKYIKENNITGRRMLVIHQFNSIMIKKRANVRSDYERVQLIHCADGFGSPQLKKDSYAYNALAQNIPLKSFKLFSKPTVAGAGYDQPMMTPDEVFNLNPRPYLIMYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RB3</accession>
    <name>Q73RB3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_0178</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970794.1">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
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        <property type="gene ID" value="TDE_0178"/>
    </dbReference>
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    <dbReference type="KEGG" id="tde:TDE_0178"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.175"/>
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    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="dCache_1"/>
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        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="309"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="410"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS10675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="696" mass="74853" checksum="D35B1B2A1DE403B9" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RD3</accession>
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        <submittedName>
            <fullName evidence="5">Adenylate/guanylate cyclase catalytic domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956687.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73RD3"/>
    <dbReference type="STRING" id="243275.TDE_0156"/>
    <dbReference type="EnsemblBacteria" id="AAS10654">
        <property type="protein sequence ID" value="AAS10654"/>
        <property type="gene ID" value="TDE_0156"/>
    </dbReference>
    <dbReference type="GeneID" id="2741744"/>
    <dbReference type="KEGG" id="tde:TDE_0156"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.154"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_286961_0_0_12"/>
    <dbReference type="OMA" id="EGRIWIA"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011110">
        <property type="entry name" value="Reg_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011123">
        <property type="entry name" value="Y_Y_Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07494">
        <property type="entry name" value="Reg_prop"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07495">
        <property type="entry name" value="Y_Y_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="763"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="4">
        <location>
            <begin position="844"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="785"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1075" mass="118411" checksum="637E7D7D8085B895" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RI4</accession>
    <name>Q73RI4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-dehydroquinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_0104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970721.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680953.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0104"/>
    <dbReference type="EnsemblBacteria" id="AAS10602">
        <property type="protein sequence ID" value="AAS10602"/>
        <property type="gene ID" value="TDE_0104"/>
    </dbReference>
    <dbReference type="GeneID" id="2741719"/>
    <dbReference type="KEGG" id="tde:TDE_0104"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.104"/>
    <dbReference type="eggNOG" id="COG0337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_0_1_12"/>
    <dbReference type="OMA" id="YGVIWDA"/>
    <dbReference type="OrthoDB" id="1677032at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHQ_synthase" evidence="7">
        <location>
            <begin position="56"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS10602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="343" mass="37710" checksum="BA5AB859E24AEE88" modified="2004-07-05" version="1">MDSFSFTTVQGTTEVFYCDEPFVPPVGTAGGMYITDSNTAPIAKGARNFRSDLPLVVIEAGEENKNFTSLVSILKAALDAGLSRNSVFIGIGGGLVCDLAAFAASVYMRGAKCKLVPTSLLAMADAAIGGKTAINFDGYKNMVGTFFKADEIYISPKVLKSLSEPEYLSGMFEIFKMGLLYSKDIYQVFRTQREKIFARDEDLCLDLVKIAVEAKALVVSRDFDEKNERAFLNLGHTFGHALESGLNFSKISHGEAVAWGISKAMLLGKNLGLTDSSYADEVCAIIHSYSRIDVPVLQDKEKVLLAMKKDKKNMDGKIRLILQKNICETFIYEAFEKDIREVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2003-11-21" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>O06679</accession>
    <name>FLIE_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flagellar hook-basal body complex protein FliE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fliE</name>
        <name type="ordered locus">TDE_1214</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1997" name="Infect. Immun." volume="65" first="2041" last="2051">
            <title>Genetic and transcriptional analysis of flgB flagellar operon constituents in the oral spirochete Treponema denticola and their heterologous expression in enteric bacteria.</title>
            <authorList>
                <person name="Heinzerling H.F."/>
                <person name="Olivares M."/>
                <person name="Burne R.A."/>
            </authorList>
            <dbReference type="PubMed" id="9169730"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FliE family.</text>
    </comment>
    <dbReference type="EMBL" id="U78776">
        <property type="protein sequence ID" value="AAB57898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971821.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671660.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O06679"/>
    <dbReference type="SMR" id="O06679"/>
    <dbReference type="STRING" id="243275.TDE_1214"/>
    <dbReference type="EnsemblBacteria" id="AAS11732">
        <property type="protein sequence ID" value="AAS11732"/>
        <property type="gene ID" value="TDE_1214"/>
    </dbReference>
    <dbReference type="GeneID" id="2740108"/>
    <dbReference type="KEGG" id="tde:TDE_1214"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1169"/>
    <dbReference type="eggNOG" id="COG1677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147249_4_1_12"/>
    <dbReference type="OMA" id="VRIDAFF"/>
    <dbReference type="OrthoDB" id="1581972at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00724">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001624">
        <property type="entry name" value="FliE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02049">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01006">
        <property type="entry name" value="FLGHOOKFLIE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00205">
        <property type="entry name" value="fliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000105568" description="Flagellar hook-basal body complex protein FliE">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00724"/>
        </source>
    </evidence>
    <sequence length="121" mass="13239" checksum="52CC322158C79B1C" modified="1997-07-01" version="1">MVNAVNVANVNSVPGLLDVPKINAVVTDNFRAKMVSNTDMIELAANKEAASFEQTILKAFDSMNAKQTNMDKLGEQMIVDPESVDVHDITMGMAEASLSLKLAQTIIDRLVKTWNDITTTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-13" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>P60941</accession>
    <name>UPPP_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uppP</name>
        <name type="synonym">bacA</name>
        <name type="synonym">upk</name>
        <name type="ordered locus">TDE_0172</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970788.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681055.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P60941"/>
    <dbReference type="SMR" id="P60941"/>
    <dbReference type="STRING" id="243275.TDE_0172"/>
    <dbReference type="EnsemblBacteria" id="AAS10669">
        <property type="protein sequence ID" value="AAS10669"/>
        <property type="gene ID" value="TDE_0172"/>
    </dbReference>
    <dbReference type="GeneID" id="2739524"/>
    <dbReference type="KEGG" id="tde:TDE_0172"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.169"/>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060296_1_2_12"/>
    <dbReference type="OMA" id="IEGPFRD"/>
    <dbReference type="OrthoDB" id="1826154at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0046">Antibiotic resistance</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000151231" description="Undecaprenyl-diphosphatase">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <sequence length="269" mass="28926" checksum="173371DB152CC2D6" modified="2004-04-13" version="1">MSIFQAIILGAVQGLAEFLPISSSGHLAIVEYFFKQEDLPILFDILLHVATLAAVCTVFAKRIAGLFSVLGRFIIRKSKPEDKDDLMMIAAIIVATAVTGVIGLLLKDWVKTIDIRLIPIFFIITGLLLIASSKIKHNKQAKNVTLLTAAITGLAQGIGVIPGISRSGSTISASLFAGLDREKAGEFSFLLSIPAILAAFILEIKSADNLLAGVSPISLISGMISAFVVGYFSLRFLLKLIKNGKLMYFAFYLIPLGLGLSIYFWGFAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-06-07" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>P61696</accession>
    <name>IF1_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">infA</name>
        <name type="ordered locus">TDE_2087</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972688.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668257.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61696"/>
    <dbReference type="SMR" id="P61696"/>
    <dbReference type="STRING" id="243275.TDE_2087"/>
    <dbReference type="EnsemblBacteria" id="AAS12607">
        <property type="protein sequence ID" value="AAS12607"/>
        <property type="gene ID" value="TDE_2087"/>
    </dbReference>
    <dbReference type="GeneID" id="2740326"/>
    <dbReference type="KEGG" id="tde:TDE_2087"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1971"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_12"/>
    <dbReference type="OMA" id="AHVSGKM"/>
    <dbReference type="OrthoDB" id="2066663at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000095896" description="Translation initiation factor IF-1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="S1-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <sequence length="72" mass="8231" checksum="54189A37F598C11F" modified="2004-06-07" version="1">MAKEEAIEVEGIVKESLPNTMFRVELKNGHVILAHLSGKMRKHYIKIVPGDTVKVALSPYDLTRGRIIFRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73IZ3</accession>
    <name>Q73IZ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973382.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680846.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13301">
        <property type="protein sequence ID" value="AAS13301"/>
        <property type="gene ID" value="TDE_2784"/>
    </dbReference>
    <dbReference type="GeneID" id="2739173"/>
    <dbReference type="KEGG" id="tde:TDE_2784"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2627"/>
    <dbReference type="eggNOG" id="ENOG5033Z9Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034372_0_0_12"/>
    <dbReference type="OMA" id="RDHEDAF"/>
    <dbReference type="OrthoDB" id="906948at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035196">
        <property type="entry name" value="DUF5312"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17239">
        <property type="entry name" value="DUF5312"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="569" mass="65555" checksum="90B09BBBE0C55A56" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J02</accession>
    <name>Q73J02_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973373.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680836.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2775"/>
    <dbReference type="EnsemblBacteria" id="AAS13292">
        <property type="protein sequence ID" value="AAS13292"/>
        <property type="gene ID" value="TDE_2775"/>
    </dbReference>
    <dbReference type="GeneID" id="2740742"/>
    <dbReference type="KEGG" id="tde:TDE_2775"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2619"/>
    <dbReference type="eggNOG" id="ENOG502ZA0R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061772_0_0_12"/>
    <dbReference type="OMA" id="TNCRINT"/>
    <dbReference type="OrthoDB" id="999184at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025389">
        <property type="entry name" value="DUF4300"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14133">
        <property type="entry name" value="DUF4300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="284" mass="32973" checksum="BAFC1FC75EFA93B5" modified="2004-07-05" version="1">MKKILTLLILILIVSCQKNNDTKEALTIQNEVQDEKPLFSNMSDDESIKEVQAVLNSHLENKNAEAFIRGVIDYNETIEKTGLTKGFEKEPPEYDEQKIDELWKSKKGNFIGTNCRINVFMLLKDNIEIKKAPIDDALLFMDNEAISVGKIFNDNDTERFKQLFSRVKTENTKDILIHAQKMKEHFTNIGFDENAKMLSVVLHDNLDGDFLFIGHTGVLLQNNSTFLFVEKLSFSEPFQAVKFAKKEDCYNYLFLKYKHYQDEDTAKPFIMENNELIELDLYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J25</accession>
    <name>Q73J25_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973349.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2751"/>
    <dbReference type="EnsemblBacteria" id="AAS13268">
        <property type="protein sequence ID" value="AAS13268"/>
        <property type="gene ID" value="TDE_2751"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2751"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2597"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_523638_0_0_12"/>
    <dbReference type="OMA" id="LISKTIW"/>
    <dbReference type="OrthoDB" id="365257at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="514" mass="60110" checksum="88A93087DC715AF2" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J53</accession>
    <name>Q73J53_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="6" type="ordered locus">TDE_2723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973321.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667047.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2723"/>
    <dbReference type="EnsemblBacteria" id="AAS13240">
        <property type="protein sequence ID" value="AAS13240"/>
        <property type="gene ID" value="TDE_2723"/>
    </dbReference>
    <dbReference type="GeneID" id="2740942"/>
    <dbReference type="KEGG" id="tde:TDE_2723"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2572"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_8_0_12"/>
    <dbReference type="OMA" id="MMLVGDI"/>
    <dbReference type="OrthoDB" id="1011035at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="5">
        <location>
            <begin position="86"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="4">
        <location>
            <begin position="213"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS13240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="418" mass="47430" checksum="4A49D3C4D5B226B0" modified="2004-07-05" version="1">MNYLESNNLAIIACPGGEEFANLTIKNLKHIYARKLYQQSEKLAKRYNTSSEDMIQKFNFYSDLFAGRMSVNKDTNKIHVPKFKVDARFTYFMNGEFKTELLETVRGKDVYIFQDVENKQEITINEGKNKEVFSVNDHLMSLIVTIDAVRHAGAGRISLVLPVYPYSRQHKKKGREGLTASLLGHIYEDLDVEQIITLDIHSREIENSFHSARLQNLHASYQIIRELTRILDLSADSEEQFVVVSPDSGAVDRNKFYSSGLQKPLAMIYKERDYSVVTQNAKQSNIISIKLLGDVEGKNAFIADDMLGTGGTLLKAMEFLKSKGAKKVIAAVSLPFFTGDAIQQFDEAYSKGLFYRVIGTNAVYHTELKQKEWYIETDVSGLFAQVITRLHENLSLSSLLDNRDIIEKLLKNAAIPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J55</accession>
    <name>Q73J55_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973319.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680776.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2721"/>
    <dbReference type="EnsemblBacteria" id="AAS13238">
        <property type="protein sequence ID" value="AAS13238"/>
        <property type="gene ID" value="TDE_2721"/>
    </dbReference>
    <dbReference type="GeneID" id="2740940"/>
    <dbReference type="KEGG" id="tde:TDE_2721"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2570"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008213_4_0_12"/>
    <dbReference type="OMA" id="PTHIHEY"/>
    <dbReference type="OrthoDB" id="377818at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="234"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="445"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS13238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="590" mass="66467" checksum="30B22C84A153C6EC" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J59</accession>
    <name>Q73J59_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidate cytidylyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973315.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680767.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2717"/>
    <dbReference type="EnsemblBacteria" id="AAS13234">
        <property type="protein sequence ID" value="AAS13234"/>
        <property type="gene ID" value="TDE_2717"/>
    </dbReference>
    <dbReference type="GeneID" id="2740936"/>
    <dbReference type="KEGG" id="tde:TDE_2717"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2566"/>
    <dbReference type="eggNOG" id="COG0170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031477_4_0_12"/>
    <dbReference type="OMA" id="VAFIVCY"/>
    <dbReference type="OrthoDB" id="1421771at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="PTHR31303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="208" mass="22865" checksum="18B8FC68C8BB7CDA" modified="2004-07-05" version="1">MSFLRNLRYKKLSQNARVEDLIKETFRKTIHLCAALVPLVARYFFYPTVIALSAITFFYVIFEILRLKGYQIFMISNITGFAARERDKGKFVLGPVTLSIGVISTLLIFPFKEASIGIMALALGDGLASLVGKFWGRQHLNISKDKTIAGSIACFTAVFISTIAISRSFIKSFFIAAIATGTEALPLKDFDNILIPLVCAGAALILAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JB3</accession>
    <name>Q73JB3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973260.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680709.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2662"/>
    <dbReference type="EnsemblBacteria" id="AAS13179">
        <property type="protein sequence ID" value="AAS13179"/>
        <property type="gene ID" value="TDE_2662"/>
    </dbReference>
    <dbReference type="GeneID" id="2741107"/>
    <dbReference type="KEGG" id="tde:TDE_2662"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2516"/>
    <dbReference type="eggNOG" id="ENOG50302A1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_979835_0_0_12"/>
    <dbReference type="OMA" id="EAMFSER"/>
    <dbReference type="OrthoDB" id="1462388at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284554" evidence="1">
        <location>
            <begin position="26"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="287" mass="32441" checksum="4AD5C0A0193B3AED" modified="2004-07-05" version="1">MNGRLELKRIIRNTLAALSFVLVFASCKTAPPLPGVVRPFGMIGDDADMYIYMPIEKNKKIAEPILTSVGGESMKQALSRTTAVYSGVFVKDRLTEIRICSTGKYPYGMTDSIFKKKNGWEPKKTKEKYKYYKSSYVDISIPSPQIACLVMGPDNRQNMEVFLGKLSKPEEAMFSERFGTLVNSGSQDIGIFVTNGDFFLGQIIGVQLGLPVGVIEMYLKKNPEVENEYLYDLSIETKNVMTASLLKLFFKKQLKADVRLEENKLIIENRSVTESRIIEIIKSLYNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JG2</accession>
    <name>Q73JG2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuc_Holl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973211.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680619.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2613"/>
    <dbReference type="EnsemblBacteria" id="AAS13130">
        <property type="protein sequence ID" value="AAS13130"/>
        <property type="gene ID" value="TDE_2613"/>
    </dbReference>
    <dbReference type="GeneID" id="2740787"/>
    <dbReference type="KEGG" id="tde:TDE_2613"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2470"/>
    <dbReference type="eggNOG" id="COG4741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105716_2_1_12"/>
    <dbReference type="OMA" id="VIFLEVK"/>
    <dbReference type="OrthoDB" id="1470271at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019287">
        <property type="entry name" value="Hday_junct_resolvase-rel_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10107">
        <property type="entry name" value="Endonuc_Holl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuc_Holl" evidence="1">
        <location>
            <begin position="29"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="134" mass="14998" checksum="E9D632CC238B88FD" modified="2004-07-05" version="1">MIKIALGISIILIFFLLGLVIGKYKERSLNLKRVNEARKDAVKRSRAVLNGQLSEQLAPFFPDFPANPTEIRFIGQPVDYIAFNGASQGTITDISFIEIKTGSAALSPVERALKDAIEKKKIKYIEYRADLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JG8</accession>
    <name>Q73JG8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973205.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673641.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2607"/>
    <dbReference type="EnsemblBacteria" id="AAS13124">
        <property type="protein sequence ID" value="AAS13124"/>
        <property type="gene ID" value="TDE_2607"/>
    </dbReference>
    <dbReference type="GeneID" id="2741311"/>
    <dbReference type="KEGG" id="tde:TDE_2607"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2465"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103354_0_0_12"/>
    <dbReference type="OMA" id="RRITAYP"/>
    <dbReference type="OrthoDB" id="1933827at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16325">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004564">
        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35869">
        <property type="entry name" value="PTHR35869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03548">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285912" evidence="1">
        <location>
            <begin position="20"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="222" mass="24720" checksum="74CB626EF4E8B23D" modified="2004-07-05" version="1">MKKNITTILFVLISSFCFSQNITTAGDFFSSVSDRYAQIQDYIVDMNITVGSSTQQATAMFKRPDKLRLDFKSPAEQCIVFNGNTLSIYLPQYRTILTQDVEQSNAGGSSLATPQGLSLIKRGYTIQYDATSAPQPLEEGSSENVIILLMNRKSATETFKTLRVMIYPDGKLIRRIEAIPVSGGKITFDFYNYRINAGVGSKNFVFDAPSTAKSFNDFLFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JU0</accession>
    <name>Q73JU0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973093.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680469.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="SMR" id="Q73JU0"/>
    <dbReference type="STRING" id="243275.TDE_2495"/>
    <dbReference type="EnsemblBacteria" id="AAS13012">
        <property type="protein sequence ID" value="AAS13012"/>
        <property type="gene ID" value="TDE_2495"/>
    </dbReference>
    <dbReference type="GeneID" id="2741468"/>
    <dbReference type="KEGG" id="tde:TDE_2495"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2362"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_1_2_12"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284891" evidence="2">
        <location>
            <begin position="33"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="3">
        <location>
            <begin position="528"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS13012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="772" mass="83721" checksum="3A6C6787ADEFCC15" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K13</accession>
    <name>Q73K13_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973176.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002676042.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2578"/>
    <dbReference type="EnsemblBacteria" id="AAS13095">
        <property type="protein sequence ID" value="AAS13095"/>
        <property type="gene ID" value="TDE_2578"/>
    </dbReference>
    <dbReference type="GeneID" id="2741282"/>
    <dbReference type="KEGG" id="tde:TDE_2578"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2438"/>
    <dbReference type="eggNOG" id="ENOG5031CQS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168243_3_0_12"/>
    <dbReference type="OMA" id="QFLEICT"/>
    <dbReference type="OrthoDB" id="1935944at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045944">
        <property type="entry name" value="DUF6364"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19891">
        <property type="entry name" value="DUF6364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="84" mass="9587" checksum="0836DB8D95C54311" modified="2004-07-05" version="1">MLAKLTLTIEQSVIEQAKEYAQKKNRSVSRIVEEYLKNIVTNHDIGTSFSKMKSPITDSISGMFHDNGKSYKDMLSEALQDKYL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K21</accession>
    <name>RNH_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease H</fullName>
            <shortName evidence="1">RNase H</shortName>
            <ecNumber evidence="1">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnhA</name>
        <name type="ordered locus">TDE_2570</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973168.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680554.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73K21"/>
    <dbReference type="SMR" id="Q73K21"/>
    <dbReference type="STRING" id="243275.TDE_2570"/>
    <dbReference type="EnsemblBacteria" id="AAS13087">
        <property type="protein sequence ID" value="AAS13087"/>
        <property type="gene ID" value="TDE_2570"/>
    </dbReference>
    <dbReference type="GeneID" id="2739935"/>
    <dbReference type="KEGG" id="tde:TDE_2570"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2429"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030894_6_0_12"/>
    <dbReference type="OMA" id="MQEIEIF"/>
    <dbReference type="OrthoDB" id="1953872at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000332686" description="Ribonuclease H">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00408"/>
        </source>
    </evidence>
    <sequence length="160" mass="17924" checksum="8A4C80780BF8BEA0" modified="2004-07-05" version="1">MNIEIYTDGACSKNPGPGGWAYIMVNKDSKEEICRENGGEKSTTNNRMELMAVIRALKKIKEGAASLADKSGKALDYKSISVHTDSQYVQQGISSWIFNWKKNNWKTASKQPVKNQDLWQELDSLSASIKPEWIWVKGHAGNPLNEACDRLAVEACQKMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K26</accession>
    <name>Q73K26_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973189.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2591"/>
    <dbReference type="EnsemblBacteria" id="AAS13108">
        <property type="protein sequence ID" value="AAS13108"/>
        <property type="gene ID" value="TDE_2591"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2591"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2449"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_1_5_12"/>
    <dbReference type="OrthoDB" id="1385159at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="33"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="119" mass="13677" checksum="ACD84896752F5D88" modified="2004-07-05" version="1">MVIFSVSCNAKSTENIIRMDGSRLEAILNDETERGKYLVIDVREDYEYKAGHVPYSINISVQEIESRISEISDWKEKNVIVICRSGRRSRAAAEILVKHGFKKIFDADGVSKYNYKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K83</accession>
    <name>Q73K83_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2337</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M29 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="10"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972936.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002683951.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2337"/>
    <dbReference type="EnsemblBacteria" id="AAS12855">
        <property type="protein sequence ID" value="AAS12855"/>
        <property type="gene ID" value="TDE_2337"/>
    </dbReference>
    <dbReference type="GeneID" id="2739432"/>
    <dbReference type="KEGG" id="tde:TDE_2337"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2206"/>
    <dbReference type="eggNOG" id="COG2309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054346_1_0_12"/>
    <dbReference type="OMA" id="CNANIPT"/>
    <dbReference type="OrthoDB" id="689314at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035097">
        <property type="entry name" value="M29_N-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00919">
        <property type="entry name" value="THERMOPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS12855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="409" mass="45888" checksum="D6D83F656351F533" modified="2004-07-05" version="1">MDFKRNIEKYVELILKVGLNIQKGDGIFVLVNEHSIGMVREVTKQAYKMGAKDVVYDFSDDEMTLARYAYGDESIFKEMPKFKIDYMEAAYKNNYHRLAIVADNPELLKNADAKKVSEWNKTRAIASKPIMKYTMENHVKWCVAAHPTPAWAKSVFPELPEEQALTKLWEKVFDATRVSMDDPVAAWKEHDAALKKHQNFLNEMAFEKLLYKGPGTDLEVYLTEGHRWVGGSGKSTRGDVFMANIPTEEVFSMPHAFKVNGTLKATKPLAARGRIINDFHFTFKDGKVIDFDAKEGKDVLQSLLDSDEGARRLGEVALVADDSPISNTGVLFKNTLFDENASCHFAIGNAYSENIKGGAEFSDEDKKKIGMNNSIIHVDFMVGGPELSVIGVKKDGTQVQILKNGNWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KB1</accession>
    <name>Q73KB1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972908.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680221.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12827">
        <property type="protein sequence ID" value="AAS12827"/>
        <property type="gene ID" value="TDE_2308"/>
    </dbReference>
    <dbReference type="GeneID" id="2740273"/>
    <dbReference type="KEGG" id="tde:TDE_2308"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2178"/>
    <dbReference type="eggNOG" id="ENOG5031UWC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1314909_0_0_12"/>
    <dbReference type="OrthoDB" id="1576943at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="209" mass="22495" checksum="AEFFEA90A8710B24" modified="2004-07-05" version="1">MNRKLFFVCLVFALVFTGMLTAKSIGLDLEVGGAYNNHQLHKIDNNYGYNGFKYHGIRSKSLGGVNIGISYPLPKNWAVFANTTFTFNNIFVNDTMLGVGYIFKPGKGFELLLGGAFAFGGSAFQWATGGAIVTESYFNLGGGINFTASYMFTGKFGIYAGASALYYKPLSGNRETKIGNSSSSVSIQPSLLPNLAKSIGLKLGLKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KF3</accession>
    <name>Q73KF3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972865.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680152.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2265"/>
    <dbReference type="EnsemblBacteria" id="AAS12784">
        <property type="protein sequence ID" value="AAS12784"/>
        <property type="gene ID" value="TDE_2265"/>
    </dbReference>
    <dbReference type="GeneID" id="2740015"/>
    <dbReference type="KEGG" id="tde:TDE_2265"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2137"/>
    <dbReference type="HOGENOM" id="CLU_071023_5_0_12"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="129" mass="14851" checksum="B9A663263A74C754" modified="2004-07-05" version="1">MGLKGKGKTTALNGGLSLPLLEVIINAEAFKDTENKELKEFLEYLKTGKTKSEFTRRIEEMIQTVKQNEQARQEYRLMSTFEMDARYKGFSEGTYNNKCETAKLMKRKNFDIALIKEITGLPESEIEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KG7</accession>
    <name>Q73KG7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uracil permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">uraA</name>
        <name evidence="8" type="ordered locus">TDE_2251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972851.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667891.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2251"/>
    <dbReference type="EnsemblBacteria" id="AAS12770">
        <property type="protein sequence ID" value="AAS12770"/>
        <property type="gene ID" value="TDE_2251"/>
    </dbReference>
    <dbReference type="GeneID" id="2741356"/>
    <dbReference type="KEGG" id="tde:TDE_2251"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2125"/>
    <dbReference type="eggNOG" id="COG2233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017959_1_2_12"/>
    <dbReference type="OMA" id="INHGIGM"/>
    <dbReference type="OrthoDB" id="1115239at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="420" mass="44221" checksum="804DB99B8D6CB693" modified="2004-07-05" version="1">MSHKRIYQVDEKVPAGLFLPLSIQHTFAMFGASVLVPIIFGIDAGIVLFMNGVGTLLFIAITKGKAPAYLGSSFAFLGPAGLIISSMGFQYAQGAFIVTGLLGCLIAFIIYKFGTSWINVILPPAAMGAVVSLIGFELTGLTVRGGTIGANIMTESASRGDIIVFFITIGAAVLGSVLFKGFLSTISILIASIAGYIAAIFFGMVDFSIIREAGLFTLPHFQLPKFDLMAVITMLPVLLVITSEHISHQVVTSNIIGKDLLKNPGLHRSIFADNFSTALSGLVGGVPTTTYGENIGVMAVTGIYSVYVIAGAAIISICMAFISPLAALIRTVPGNVIGGITFLLYGMIGASGIRLLVDSKVDYSKSKNLILTSIVFTTGLSGLSIKFGEIEFKGMVLASLVAVALSLIFFIFEKLGVLEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KJ8</accession>
    <name>SYP_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="1">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proS</name>
        <name type="ordered locus">TDE_2220</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972820.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957184.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KJ8"/>
    <dbReference type="SMR" id="Q73KJ8"/>
    <dbReference type="STRING" id="243275.TDE_2220"/>
    <dbReference type="EnsemblBacteria" id="AAS12739">
        <property type="protein sequence ID" value="AAS12739"/>
        <property type="gene ID" value="TDE_2220"/>
    </dbReference>
    <dbReference type="GeneID" id="2739496"/>
    <dbReference type="KEGG" id="tde:TDE_2220"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2097"/>
    <dbReference type="eggNOG" id="COG0442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_0_0_12"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="OrthoDB" id="665824at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000248805" description="Proline--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <sequence length="595" mass="66299" checksum="E042A15FBF5DF833" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KL3</accession>
    <name>Q73KL3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enoate reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_2205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972805.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2205"/>
    <dbReference type="EnsemblBacteria" id="AAS12724">
        <property type="protein sequence ID" value="AAS12724"/>
        <property type="gene ID" value="TDE_2205"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2205"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2082"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_1_2_12"/>
    <dbReference type="OMA" id="PRGAYTW"/>
    <dbReference type="OrthoDB" id="1308229at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="10"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="329"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="428"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="726" mass="79781" checksum="9F03FEE0A0224A94" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KR7</accession>
    <name>Q73KR7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972751.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2150"/>
    <dbReference type="EnsemblBacteria" id="AAS12670">
        <property type="protein sequence ID" value="AAS12670"/>
        <property type="gene ID" value="TDE_2150"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2150"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2031"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070263_0_0_12"/>
    <dbReference type="OMA" id="WEWAGIY"/>
    <dbReference type="OrthoDB" id="620845at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="340" mass="40244" checksum="3B5BD0E01B3D5F0F" modified="2004-07-05" version="1">MFMLCLIFISCKQDPDLYLYDDMDNLKDEQKTLIEVLKKTESKEMSFAVKDRIAKNLKVKKKNKLLIVFLSSLVENDPDDTYKGYWLLMLANEYMEQKMNEPAAYFFERVIKLDKDMEISGKSIQYLSLKNLINITNDPKRLVEYYSLLLSNFYDSIDPAYSYFMLAQNYEKLGEWNLAIQSYSKFIGLGRFDLIIPGIPDNYGYARKIVDYSSSTKSWTMESLDELLSVIKSAIQRKDYDTLERYRSKVNFFSMAWKQELSDIYGSPDFSLRNFMYGTYIKIEPEIDPSSTPHEAYLKTSGWNQYSRIWYLYFRKVNFPADPEIHGRWEWAGIYYGEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KU6</accession>
    <name>Q73KU6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Epoxyqueuosine reductase QueH</fullName>
            <ecNumber evidence="5 12">1.17.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Queuosine biosynthesis protein QueH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">queH</name>
        <name evidence="13" type="ordered locus">TDE_2121</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:32159"/>
            <dbReference type="Rhea" id="RHEA-COMP:10345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82831"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="1.17.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the QueH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.99.6" evidence="5 12"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972722.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957156.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2121"/>
    <dbReference type="EnsemblBacteria" id="AAS12641">
        <property type="protein sequence ID" value="AAS12641"/>
        <property type="gene ID" value="TDE_2121"/>
    </dbReference>
    <dbReference type="GeneID" id="2739380"/>
    <dbReference type="KEGG" id="tde:TDE_2121"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2004"/>
    <dbReference type="eggNOG" id="COG1636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088177_1_0_12"/>
    <dbReference type="OMA" id="PNIHPYT"/>
    <dbReference type="OrthoDB" id="1078220at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02089">
        <property type="entry name" value="QueH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003828">
        <property type="entry name" value="QueH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36701">
        <property type="entry name" value="PTHR36701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02677">
        <property type="entry name" value="QueH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="198"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAS12641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="205" mass="23805" checksum="6EF4C144EF9C2111" modified="2004-07-05" version="1">MMPQKINYDRLMQETIKNLGSNDKTLLLHSCCAPCSSSVILKLAPFFKLTVFYYNSNIDTSEEYEKRAEEQRHLISIYNEENLSSHKIEIIKEAYDPQEFYEISQGLEDCPEGGERCMRCYLLRLKKTAERAKKDGFDFFTSTLSVSPLKNAEKLNTIGLSLESEGCKWLPSDFKKRNGYLDSINLSKKYGLYRQDYCGCKYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KW0</accession>
    <name>Q73KW0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydroorotase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2107</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972708.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679913.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2107"/>
    <dbReference type="EnsemblBacteria" id="AAS12627">
        <property type="protein sequence ID" value="AAS12627"/>
        <property type="gene ID" value="TDE_2107"/>
    </dbReference>
    <dbReference type="GeneID" id="2740346"/>
    <dbReference type="KEGG" id="tde:TDE_2107"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1990"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_1_12"/>
    <dbReference type="OMA" id="HSTGNMG"/>
    <dbReference type="OrthoDB" id="906155at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016812">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS12627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="371" mass="41016" checksum="B485C11A4E60D5F4" modified="2004-07-05" version="1">MIDSHVHLRDGLLSDKETIAHALALACPAGFTAFFDMPNTNPPLTNAEAVLERFALAEKSIKQAGVSAFYGIYGGLTSDIAQIEKMVLFYKKYFPKIVGFKMFAGHSTGNMGIVEKEDQRKVYAALKKFDYRGILAVHCEKESLMNNSIFDIENPITHSLARPPIAETESIKDQIELMQSEDFKGHLHVCHISTKEGIRLVAEAKKSGLSISCGATAHHALLNIDSYKKSGIFVKMNPPLREKEEQEAVFNALISGGIDWIESDHAPHTYEDKKKGASGIPGFAGSLILLKELRKAGCSEKRLDELCGKAVNHIFKLDLSYKVPSNTEIDASLPSLRSGYPFDAFEFFGISKFSFLNFIVTLTICTIAYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KW6</accession>
    <name>Q73KW6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972702.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679905.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2101"/>
    <dbReference type="EnsemblBacteria" id="AAS12621">
        <property type="protein sequence ID" value="AAS12621"/>
        <property type="gene ID" value="TDE_2101"/>
    </dbReference>
    <dbReference type="GeneID" id="2740340"/>
    <dbReference type="KEGG" id="tde:TDE_2101"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1984"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_1_0_12"/>
    <dbReference type="OMA" id="VTMISWR"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284914" description="FGE-sulfatase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="90"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="356" mass="38991" checksum="E7AE3E8AF59B7AB7" modified="2004-07-05" version="1">MKKFFVLFLAILFVSVSACKNPFFKNMLDKDSGSEGTGDWNSQSSDVGSFEDAGDFVKIIPPANGIVGVAPNYALPGNHDYWKGVFIAGRTVKLSPYKIGKMEVTYELWYSVLKWNTDNGRGYIFANQGREGSNGGEGVAPTGAKKEPVTMISWRDCIVWCNAYTEKEKGIGECVYRKKDNHTVVLKDATATAACDSAYADMNKKGFRLPTEAEWEYAARRQGSNTENAAQYGDVWLTKLNSASGAKDKWDTAETGEVAWYKGNSGNKTHPVGKKRANALGLYDMSGNVTEWCFDWDDTIAAENVTDPQGAASGSARVERGGSWLNYAYGCTVGVRYCVTPGSRSDNLGFRLACRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KW9</accession>
    <name>Q73KW9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972699.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2098"/>
    <dbReference type="EnsemblBacteria" id="AAS12618">
        <property type="protein sequence ID" value="AAS12618"/>
        <property type="gene ID" value="TDE_2098"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2098"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1981"/>
    <dbReference type="HOGENOM" id="CLU_3223401_0_0_12"/>
    <dbReference type="OrthoDB" id="1021387at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="44" mass="5352" checksum="D18758D53DABC9DD" modified="2004-07-05" version="1">MKQLFKITLRNDYAFKRVFGTEENKDVLQDLLECILDSNMFFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L14</accession>
    <name>Q73L14_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 6">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">TDE_2052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972654.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679842.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2052"/>
    <dbReference type="EnsemblBacteria" id="AAS12565">
        <property type="protein sequence ID" value="AAS12565"/>
        <property type="gene ID" value="TDE_2052"/>
    </dbReference>
    <dbReference type="GeneID" id="2740646"/>
    <dbReference type="KEGG" id="tde:TDE_2052"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1937"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_12"/>
    <dbReference type="OMA" id="HKLCGPT"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="17"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS12565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="400" mass="44183" checksum="1303B7677EB7CE08" modified="2004-07-05" version="1">MYKNDFPLLMQNPNIHYLDSAATAQRPMPVIEGIKEYFLQSNGNAGRGSHSLAIASSILVEETRKKTAEFIGADKIESIIFTKNSTEALNIIAYCYGLSNLKTGDEILLAVSNHHANLVPWQFVAKQTGAAVKFIYLNKNGTLDINDFKAKLSSKTKVVAISSVVNATGIINPVEEVIKLSHESGAVVVVDAAQAIAHYKQDVSALDCDFLVFSGHKIFSDFGVGVLYGKKELLDKMPPFLYGGDMINFVTEESSEFKEAPYKYEGGTHDTAAIVSLKHAIEYIEKIGYANIEKTVKELDSYALSELKKLDFVETYGTDAEKRAGIIAFNVKDVHSHDTSYILNEYGVMVRSGHHCTQPLMAYLNINSCCRASFSIFNTKEDIDVMITALKKVKSVFLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L96</accession>
    <name>Q73L96_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sigma-54 dependent transcriptional regulator/response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_1969</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972572.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002675346.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1969"/>
    <dbReference type="EnsemblBacteria" id="AAS12483">
        <property type="protein sequence ID" value="AAS12483"/>
        <property type="gene ID" value="TDE_1969"/>
    </dbReference>
    <dbReference type="GeneID" id="2741532"/>
    <dbReference type="KEGG" id="tde:TDE_1969"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1861"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_12"/>
    <dbReference type="OMA" id="DWTGNIR"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="8">
        <location>
            <begin position="143"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS12483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="473" mass="53081" checksum="5731363FB19C305A" modified="2004-07-05" version="1">MKFSILVIDDEKNIREGLAMALEDEGYEVITADNGKTGLDIALKDEVDLVITDLKMPEISGEEVLREVISKTPGVPVIVLTGHGTVETAVEAMRMGAYDFLTKPLDLERLFLLVKRALQNRALVLQNRALLHDIETKQSFENIIGKSPLMEKVFENIKKVAPTKASVLITGETGVGKELIARAIHNLSNRKDKPFVQVHCASFAESLLESELFGHEKGAFTGAVQRSRGRFEIANGGSLFLDEIGEVNQMIQVKLLRVLQEKKFERVGGSETISVDTRIIAATNRDLVEEIKKGNFREDLYFRLNVVHIHVPPLRERKEDIPLLVAAFIKDFAEENGKKIDSMEPRARAAIYNYEWPGNIRQLQNCIQSAVVMSSDNVIHFDDLPETLREKAEASSIRIPMGVNMAEAEKQIILQTLANQNNNKSKTADILGIGRRTLHRKLDEYDAEIKDDTSRMLEGKENQSKKEKVNGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LE7</accession>
    <name>Q73LE7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972521.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679623.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1918"/>
    <dbReference type="EnsemblBacteria" id="AAS12432">
        <property type="protein sequence ID" value="AAS12432"/>
        <property type="gene ID" value="TDE_1918"/>
    </dbReference>
    <dbReference type="GeneID" id="2740416"/>
    <dbReference type="KEGG" id="tde:TDE_1918"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1815"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073854_0_0_12"/>
    <dbReference type="OMA" id="WENDIID"/>
    <dbReference type="OrthoDB" id="1653797at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="317" mass="36296" checksum="4709EF937DC6F525" modified="2004-07-05" version="1">MNTIPTIFNERKIPYTVLGKSSGDFKAPISVLVLNRGARYYLSSLFQNLIDLGFNSIVFVDSSKRGFEVEALSSQFPEVKFLLPLEKVTAGEMINLGISEVSSDYVMVLWNDMALSSSAFPETVIDTLTQSDVICVAPVLIDEKNTLIPVQIVPSLTRRDFSTEQFLCRKDLTHTIYMYDFAGIYNREKFIEMGGFDYTIENPYWQNLDFGFRAHLWGMEILISNLYKMKYAGACPLEDISADDSYIKFYLKNLAPIVGKKGGGLPWYLFFSYAIRSGLNPFKAYKYFKAVQDWVHINKYRFVKSPQDLICKWEPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LL3</accession>
    <name>Q73LL3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972453.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679546.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1849"/>
    <dbReference type="EnsemblBacteria" id="AAS12364">
        <property type="protein sequence ID" value="AAS12364"/>
        <property type="gene ID" value="TDE_1849"/>
    </dbReference>
    <dbReference type="GeneID" id="2740038"/>
    <dbReference type="KEGG" id="tde:TDE_1849"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1754"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081285_1_0_12"/>
    <dbReference type="OMA" id="DYAWRDI"/>
    <dbReference type="OrthoDB" id="963283at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033399">
        <property type="entry name" value="Put_LolA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17131">
        <property type="entry name" value="LolA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="255" mass="29564" checksum="BCA3E41B901FFB6F" modified="2004-07-05" version="1">MKYFINKKLLIILIAFLVSIAVFAEIPSMEEMYKIMDKVFDTGNFKKDFTSTLTLIVEKPNQPKEVVQFKLFRRDTKDQTTLIQLAPEADKGNGYLQEKENLWFYDPIAHQFTHSSLKRNLANSDTKLSDVNKKSQFRQAWEILKIEEAKLGKYEVYAVTAKALEKDAAYAQEKFFVRKDEHLLLKIESYGASGKHMRTTLIPKYANVEGMPLPVHQIYINELIKGEKTTQIFQDFSTAKIDDVVFTKAYLEKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LL5</accession>
    <name>Q73LL5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972451.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1847"/>
    <dbReference type="EnsemblBacteria" id="AAS12362">
        <property type="protein sequence ID" value="AAS12362"/>
        <property type="gene ID" value="TDE_1847"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1847"/>
    <dbReference type="HOGENOM" id="CLU_3384323_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="33" mass="3694" checksum="2C4BFC18EE493E21" modified="2004-07-05" version="1">MHVEDCFLLSNARTTAIHGRANPARGEPRTRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LM8</accession>
    <name>Q73LM8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1778</name>
        <name evidence="2" type="ordered locus">TDE_1834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405</strain>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972382.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972438.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1778"/>
    <dbReference type="EnsemblBacteria" id="AAS12293">
        <property type="protein sequence ID" value="AAS12293"/>
        <property type="gene ID" value="TDE_1778"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12349">
        <property type="protein sequence ID" value="AAS12349"/>
        <property type="gene ID" value="TDE_1834"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1778"/>
    <dbReference type="KEGG" id="tde:TDE_1834"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1694"/>
    <dbReference type="HOGENOM" id="CLU_3334245_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="38" mass="4413" checksum="B4C901B7641C22A7" modified="2004-07-05" version="1">MDEEILENKLSIVFAKKTSSIINQLNLILLRLMEILIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LV0</accession>
    <name>Q73LV0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, haloacid dehalogenase-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972366.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679505.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1762"/>
    <dbReference type="EnsemblBacteria" id="AAS12277">
        <property type="protein sequence ID" value="AAS12277"/>
        <property type="gene ID" value="TDE_1762"/>
    </dbReference>
    <dbReference type="GeneID" id="2740607"/>
    <dbReference type="KEGG" id="tde:TDE_1762"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1684"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1165406_0_0_12"/>
    <dbReference type="OMA" id="EYRICEA"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="239" mass="28240" checksum="C6FAA055F55929B4" modified="2004-07-05" version="1">MKQYTSYLFDMGSTLLEFHNSKWNESEILKNGHKRMTSHISGIYGQSIADKIDKEVILPWYDYVEKERKIKRLEYRICEALFLKFGELGIHISYNEIIEILKKDYLDFYNYAHPNEGVIDCLKFLKEKKCKIGVVSNIMYPKEIYLEIFKREGLDLFIDNYTFSYENTYMKPHSSIFLRALMSLNAKISETLMVGDNEKVDVIGAKAVGLKTCLYDKDKKYKQHQADFYINNFMELIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LV3</accession>
    <name>Q73LV3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972363.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679498.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1759"/>
    <dbReference type="EnsemblBacteria" id="AAS12274">
        <property type="protein sequence ID" value="AAS12274"/>
        <property type="gene ID" value="TDE_1759"/>
    </dbReference>
    <dbReference type="GeneID" id="2740604"/>
    <dbReference type="KEGG" id="tde:TDE_1759"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1681"/>
    <dbReference type="HOGENOM" id="CLU_1502841_0_0_12"/>
    <dbReference type="OrthoDB" id="2140620at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="191" mass="22366" checksum="B1CBFC07E133DABB" modified="2004-07-05" version="1">MKKTFLLLIFFSLCIISVYSYEAKFINPLNGNVVIYRGDEYHGSGKYYFIEDNKEILIIETECYYGPQVFWYGNDIIEIYIPFGSPFNGSYIYNSKTKSISNFIENILTVFPDDNILVCSDGFEKFIFIDIGTQKIVQVIKIDEITGSYLSIREAFDIKLMLEKILIGIYIDPKSLKEFETVKYYSFKREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LX5</accession>
    <name>Q73LX5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972341.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670896.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1737"/>
    <dbReference type="EnsemblBacteria" id="AAS12252">
        <property type="protein sequence ID" value="AAS12252"/>
        <property type="gene ID" value="TDE_1737"/>
    </dbReference>
    <dbReference type="GeneID" id="2739195"/>
    <dbReference type="KEGG" id="tde:TDE_1737"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1660"/>
    <dbReference type="eggNOG" id="ENOG5031CW5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1864276_0_0_12"/>
    <dbReference type="OrthoDB" id="2033589at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="138" mass="14822" checksum="560E96C1D24D9572" modified="2004-07-05" version="1">MSFGKIIKGYGSVFFGLLTFSAIAGVCVLAGIAVAYPLWLLAATNVSLYTIISISIFVCGILYLLVKKAVKAYKKSPRGLIISILKKITVIGGLILCIKLVLTFNKIPALVVLILIFVIYGFLAFGIDQSKNNGNEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LY4</accession>
    <name>Q73LY4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972332.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679447.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1728"/>
    <dbReference type="EnsemblBacteria" id="AAS12243">
        <property type="protein sequence ID" value="AAS12243"/>
        <property type="gene ID" value="TDE_1728"/>
    </dbReference>
    <dbReference type="GeneID" id="2739186"/>
    <dbReference type="KEGG" id="tde:TDE_1728"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1652"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_422578_0_0_12"/>
    <dbReference type="OMA" id="WITANWH"/>
    <dbReference type="OrthoDB" id="383331at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="672" mass="76682" checksum="827D6680242D967D" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M53</accession>
    <name>NUSB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nusB</name>
        <name type="ordered locus">TDE_1657</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972262.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679351.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73M53"/>
    <dbReference type="SMR" id="Q73M53"/>
    <dbReference type="STRING" id="243275.TDE_1657"/>
    <dbReference type="EnsemblBacteria" id="AAS12173">
        <property type="protein sequence ID" value="AAS12173"/>
        <property type="gene ID" value="TDE_1657"/>
    </dbReference>
    <dbReference type="GeneID" id="2738998"/>
    <dbReference type="KEGG" id="tde:TDE_1657"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1584"/>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087843_3_0_12"/>
    <dbReference type="OMA" id="DAFLILY"/>
    <dbReference type="OrthoDB" id="1574817at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0889">Transcription antitermination</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000265622" description="Transcription antitermination protein NusB">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <sequence length="136" mass="15362" checksum="5E39AFD4FF6497CC" modified="2004-07-05" version="1">MSVGRRRGRILAFQALVAWDVGGAVLDDLLNFSWQNEDSIKDPNGYLFPKMMVLGTIENITEIDKVIQENLDNWVIDRLNSVDKAILRLSVYSLIYQKDTPPPIVIDEAINLAKDFGTDDSYKFVNAVLDSIKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M56</accession>
    <name>Q73M56_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-dependent helicase HrpA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972259.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1654"/>
    <dbReference type="EnsemblBacteria" id="AAS12170">
        <property type="protein sequence ID" value="AAS12170"/>
        <property type="gene ID" value="TDE_1654"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1654"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1581"/>
    <dbReference type="eggNOG" id="COG1643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_8_12"/>
    <dbReference type="OMA" id="DHDLKRY"/>
    <dbReference type="OrthoDB" id="58588at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="41"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="235"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="870" mass="99050" checksum="69E110D9D39EED6D" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MA9</accession>
    <name>Q73MA9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_1600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12117.1"/>
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    <dbReference type="RefSeq" id="WP_002679279.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="EnsemblBacteria" id="AAS12117">
        <property type="protein sequence ID" value="AAS12117"/>
        <property type="gene ID" value="TDE_1600"/>
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    <dbReference type="GeneID" id="2740841"/>
    <dbReference type="KEGG" id="tde:TDE_1600"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1530"/>
    <dbReference type="eggNOG" id="COG1132">
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    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
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    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC1_TM_sf"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
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    </feature>
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        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
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        <location>
            <begin position="26"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="338"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="370"/>
            <end position="377"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="AAS12117.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="583" mass="65154" checksum="08FD2E72F7F0C48D" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73ME8</accession>
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            <fullName evidence="1">YD repeat protein</fullName>
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    </protein>
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        <name evidence="1" type="ordered locus">TDE_1560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
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            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
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    </dbReference>
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        <property type="entry name" value="Rhs_assc_core"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="AAS12077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="1126" mass="129198" checksum="C6F34E209FD6AD03" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MF2</accession>
    <name>Q73MF2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved domain protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
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                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family.</text>
    </comment>
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        <property type="protein sequence ID" value="AAS12073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1556"/>
    <dbReference type="DNASU" id="2739306"/>
    <dbReference type="EnsemblBacteria" id="AAS12073">
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        <property type="gene ID" value="TDE_1556"/>
    </dbReference>
    <dbReference type="GeneID" id="2739306"/>
    <dbReference type="KEGG" id="tde:TDE_1556"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1492"/>
    <dbReference type="eggNOG" id="COG1450">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
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        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="400" mass="45481" checksum="7E897D610AA1AF5C" modified="2004-07-05" version="1">MRKKTILFILFFSVCMLYGQEGVKDTKSEKYELKYIEVKKFIDALPEELKKNKINVLADINGFIIRCTQEEQKIVEEYIKILDIEKEERAILLKYISSEELLKHLPPAVNRESIVVTGNPNLIFFRGSNIKREKFLKEMELIDKPKAQIRYQLLVVQYEKSENINWAKSLEVKKAKGKPMSEFSGIMSNIFNINFDIVSKFGYQFIAKLNFELAENKARVLADTTLNGITGEEVRFQNTNTFRYIDKTLDSNGKPLYGSMREITSGLLLNIKGNVSGDGMITMEVNAQVSKQGSGGVTSGVLPPTSEKIVKTKVRTPSGKPIIIGGLLQVEQNSSEKKIPGLGDIPIAGLAFKDINGSETVTEMVIYIVPYIHREREKKMGKKERLLRLYKKYIEGEDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MG8</accession>
    <name>Q73MG8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972146.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671181.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1540"/>
    <dbReference type="EnsemblBacteria" id="AAS12057">
        <property type="protein sequence ID" value="AAS12057"/>
        <property type="gene ID" value="TDE_1540"/>
    </dbReference>
    <dbReference type="GeneID" id="2740902"/>
    <dbReference type="KEGG" id="tde:TDE_1540"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1477"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125010_1_0_12"/>
    <dbReference type="OMA" id="RTFPFWD"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="148" mass="17519" checksum="4D12A5061C7DD954" modified="2004-07-05" version="1">MDKQFWKSGLNFSCTRCSACCRFDPGFVFLSEHDLSRLLEWATMPKDEFIKVYCRWVPKDDGFEYLSLKEKPNYDCILWDDGCKAYTARPRQCSDFPFWNSILSSKDMWDINARYCPGMGKGEFYSAEKIEKILTRRKAEPCIKRRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MH8</accession>
    <name>Q73MH8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972136.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679176.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1530"/>
    <dbReference type="EnsemblBacteria" id="AAS12047">
        <property type="protein sequence ID" value="AAS12047"/>
        <property type="gene ID" value="TDE_1530"/>
    </dbReference>
    <dbReference type="GeneID" id="2740892"/>
    <dbReference type="KEGG" id="tde:TDE_1530"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1467"/>
    <dbReference type="eggNOG" id="ENOG5032Q7E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1102402_0_0_12"/>
    <dbReference type="OrthoDB" id="1384655at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="258" mass="30339" checksum="36F505967F941DA8" modified="2004-07-05" version="1">MATGKVHDEHIANILGKEFSLKRPEELRLIQDAVYVLMDATVKDKNGKRLNEALQRFRDWNIADINPDEIVAPESSASTHQYYAHRGWDYNYEVEGLAEQLNTQEWQIWDLKQKEEFKTHLYKSQVRFKLGKEILIKSIREIFPYFNIQKTEALARIFYYTHIYGDLRWNSRLDYLIDVPEFRDGLIGGLRDFASPKDKEKINKLISKIMKELPDGLKFTIPADGDNAPIEDWKHCLPLDRAMEAVFEYFSLCQVFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MI7</accession>
    <name>Q73MI7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydro-lyase, tartrate/fumarate family, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972127.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669045.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1521"/>
    <dbReference type="EnsemblBacteria" id="AAS12038">
        <property type="protein sequence ID" value="AAS12038"/>
        <property type="gene ID" value="TDE_1521"/>
    </dbReference>
    <dbReference type="GeneID" id="2739727"/>
    <dbReference type="KEGG" id="tde:TDE_1521"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1460"/>
    <dbReference type="eggNOG" id="COG1838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098588_2_0_12"/>
    <dbReference type="OMA" id="IYHCGPL"/>
    <dbReference type="OrthoDB" id="1627779at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="7"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="187" mass="20457" checksum="48CFCB62372BCE9E" modified="2004-07-05" version="1">MSEMKKLTTPFTREDLKDVKAGDIVLLNGYIYTGRDAAHKRLCELLEKGEKLPIDVKGAVMYYVGPSPAKPGEPIGSAGPTTSYRMDAYTPQLLDEGLMAMVGKGKRNDEVVAKIIEHGACYFAAIGGAAALIKSRIKSAEVICYEDLGAEAVRKLYVEDFPVTCIIDSKGNNLYKLGREEYLKSLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MK4</accession>
    <name>RL31_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmE</name>
        <name type="ordered locus">TDE_1504</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972110.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669000.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MK4"/>
    <dbReference type="SMR" id="Q73MK4"/>
    <dbReference type="STRING" id="243275.TDE_1504"/>
    <dbReference type="EnsemblBacteria" id="AAS12021">
        <property type="protein sequence ID" value="AAS12021"/>
        <property type="gene ID" value="TDE_1504"/>
    </dbReference>
    <dbReference type="GeneID" id="2739905"/>
    <dbReference type="KEGG" id="tde:TDE_1504"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1443"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114306_4_3_12"/>
    <dbReference type="OMA" id="WYPDAKV"/>
    <dbReference type="OrthoDB" id="2014569at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000173173" description="50S ribosomal protein L31">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <sequence length="67" mass="7749" checksum="F21DB90D33F3FC40" modified="2004-07-05" version="1">MKKDIHPKYEETTVTCACGNVINTRSTVKDIKVEICSQCHPFFTGKQKLVDTAGRIDRFKKRYNIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MP1</accession>
    <name>Q73MP1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972073.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679131.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1467"/>
    <dbReference type="EnsemblBacteria" id="AAS11984">
        <property type="protein sequence ID" value="AAS11984"/>
        <property type="gene ID" value="TDE_1467"/>
    </dbReference>
    <dbReference type="GeneID" id="2741582"/>
    <dbReference type="KEGG" id="tde:TDE_1467"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1408"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_13_12"/>
    <dbReference type="OMA" id="FLASMHD"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="180"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="386" mass="44657" checksum="7A71ADF982F07C7A" modified="2004-07-05" version="1">MKKRKNKNKSKIKSNEKDFLTLDEVEMLDEVEEELEEMKEDLYQDDQDNPMNFNNTEIKTEVLKTAVDLLATPTVCSMLLDKNFLILYISDAVNHLFEGYHNIEKKPFFNIFGSTLEKSALDDLLTKLKSPNRGYSWSGVLRHKTRYRKTMYTKTNIFPLFDNNTLNGYWVMFEDISNSYLSQYKGMMESLLNASKLKDNDTGFHNERLNYYSKALAEALFKENLFPQIDADFIDNISSLAAIHDIGKIGTPDYILQKKGALNDVEWAVMREHTINGTLILANYPIHMAKEITLSHHERWDGKGYPYKLAGEMIPLSARIVAVADVYDALRMRRSYKEGISHKESIEHIINGAGAHFDPTIIEVFKTIDKEFSYIWEQNKDQNQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MQ3</accession>
    <name>Q73MQ3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972061.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671306.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1455"/>
    <dbReference type="DNASU" id="2741418"/>
    <dbReference type="EnsemblBacteria" id="AAS11972">
        <property type="protein sequence ID" value="AAS11972"/>
        <property type="gene ID" value="TDE_1455"/>
    </dbReference>
    <dbReference type="GeneID" id="2741418"/>
    <dbReference type="KEGG" id="tde:TDE_1455"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1396"/>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166037_0_1_12"/>
    <dbReference type="OMA" id="EYEKMQA"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="88" mass="10157" checksum="94022C016BA66B25" modified="2004-07-05" version="1">MNTIRPVSDLRNNFADISKIVHQSQQPVFLTKNGYGDMVVMSMETFEDMKFESDIYSKLQEAEKQASLTGKRFSSKDVFEEIQKLISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MR5</accession>
    <name>Q73MR5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase, TrmH family, group 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972049.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679077.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1443"/>
    <dbReference type="EnsemblBacteria" id="AAS11960">
        <property type="protein sequence ID" value="AAS11960"/>
        <property type="gene ID" value="TDE_1443"/>
    </dbReference>
    <dbReference type="GeneID" id="2741406"/>
    <dbReference type="KEGG" id="tde:TDE_1443"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1384"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_0_1_12"/>
    <dbReference type="OMA" id="GASQYVK"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="258" mass="28593" checksum="093A5ED405F743B8" modified="2004-07-05" version="1">MKKIITGFHAIDEILRAEKLKIEKEKNRKPSLEIFYSKEGPRVKKILEAARKLNLKIEKKDNQFLDSLTKTLPEQLRDHRGIVLVTEAENQKKGMSVDEFFAKLAEKGSAFVVILDSVTDPHNTGSIIRSADQFGIDGIIVPENKSAGGFEIISKVSAGALAWVPFVEVTNLVRTVERLKKEGFWIYGADAGGKALPNLTFPKKTVLIMGNEGRGMSRLVEETCDEIVSIPTKGKLDSLNVSVAAGILLYEISRKKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MU2</accession>
    <name>Q73MU2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotidyl transferase/aminotransferase, class V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2019" name="Nat. Commun." volume="10" first="3698" last="3698">
            <title>The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis.</title>
            <authorList>
                <person name="Rice K."/>
                <person name="Batul K."/>
                <person name="Whiteside J."/>
                <person name="Kelso J."/>
                <person name="Papinski M."/>
                <person name="Schmidt E."/>
                <person name="Pratasouskaya A."/>
                <person name="Wang D."/>
                <person name="Sullivan R."/>
                <person name="Bartlett C."/>
                <person name="Weadge J.T."/>
                <person name="Van der Kamp M.W."/>
                <person name="Moreno-Hagelsieb G."/>
                <person name="Suits M.D."/>
                <person name="Horsman G.P."/>
            </authorList>
            <dbReference type="PubMed" id="31420548"/>
            <dbReference type="DOI" id="10.1038/s41467-019-11627-6"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972021.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679016.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="PDB" id="6PD1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.72 A"/>
        <property type="chains" value="A/B/C/D=1-616"/>
    </dbReference>
    <dbReference type="PDB" id="6PD2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A/B/C/D=1-616"/>
    </dbReference>
    <dbReference type="PDBsum" id="6PD1"/>
    <dbReference type="PDBsum" id="6PD2"/>
    <dbReference type="SMR" id="Q73MU2"/>
    <dbReference type="STRING" id="243275.TDE_1415"/>
    <dbReference type="EnsemblBacteria" id="AAS11932">
        <property type="protein sequence ID" value="AAS11932"/>
        <property type="gene ID" value="TDE_1415"/>
    </dbReference>
    <dbReference type="GeneID" id="2739692"/>
    <dbReference type="KEGG" id="tde:TDE_1415"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1357"/>
    <dbReference type="eggNOG" id="COG0075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_512800_0_0_12"/>
    <dbReference type="OMA" id="MGTLEVC"/>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047304">
        <property type="term" value="F:2-aminoethylphosphonate-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019700">
        <property type="term" value="P:organic phosphonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01376">
        <property type="entry name" value="PhnW_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012703">
        <property type="entry name" value="NH2EtPonate_pyrv_transaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03301">
        <property type="entry name" value="PhnW-AepZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="3">
        <location>
            <begin position="5"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotran_5" evidence="2">
        <location>
            <begin position="307"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="6PD1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="6PD2"/>
        </source>
    </evidence>
    <sequence length="616" mass="68993" checksum="8FC0BCC1F5BC6F5F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MU6</accession>
    <name>Q73MU6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972017.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679006.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1411"/>
    <dbReference type="EnsemblBacteria" id="AAS11928">
        <property type="protein sequence ID" value="AAS11928"/>
        <property type="gene ID" value="TDE_1411"/>
    </dbReference>
    <dbReference type="GeneID" id="2739688"/>
    <dbReference type="KEGG" id="tde:TDE_1411"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1353"/>
    <dbReference type="eggNOG" id="ENOG5031CXI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2588682_0_0_12"/>
    <dbReference type="OMA" id="FLELMSA"/>
    <dbReference type="OrthoDB" id="2075048at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="79" mass="9095" checksum="92834646E94294E2" modified="2004-07-05" version="1">MTLYEYYIVYPDGEKQEIGGPISVGAFLDINGNELPQRLPTNKMIVYQVQSKRTIENRGIVQIIYVVEQLDAEELLDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MV8</accession>
    <name>Q73MV8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972004.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678983.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1398"/>
    <dbReference type="EnsemblBacteria" id="AAS11915">
        <property type="protein sequence ID" value="AAS11915"/>
        <property type="gene ID" value="TDE_1398"/>
    </dbReference>
    <dbReference type="GeneID" id="2741265"/>
    <dbReference type="KEGG" id="tde:TDE_1398"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1340"/>
    <dbReference type="eggNOG" id="COG1315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012504_0_0_12"/>
    <dbReference type="OMA" id="ERFEQHF"/>
    <dbReference type="OrthoDB" id="61565at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005646">
        <property type="entry name" value="FapA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38032">
        <property type="entry name" value="PTHR38032"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03961">
        <property type="entry name" value="FapA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="728" mass="80467" checksum="7824AE14BEAFD779" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MW8</accession>
    <name>Q73MW8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971994.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1388"/>
    <dbReference type="EnsemblBacteria" id="AAS11905">
        <property type="protein sequence ID" value="AAS11905"/>
        <property type="gene ID" value="TDE_1388"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1388"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1330"/>
    <dbReference type="eggNOG" id="COG1963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073969_1_1_12"/>
    <dbReference type="OMA" id="QPIEVFF"/>
    <dbReference type="OrthoDB" id="1864362at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003832">
        <property type="entry name" value="DUF212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31446">
        <property type="entry name" value="PTHR31446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02681">
        <property type="entry name" value="DUF212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="158" mass="17599" checksum="D6BC3A4F61E605CB" modified="2004-07-05" version="1">MYKMQWIMFFSNPIFLSAITSWMMSQIIKTIFALFNASIKTPIDFFELVFWRTGGMPSSHSALVASLTVSIGIRQGFDSDLFIFACFMALIVIRDAVGVRRSSGLQAKALNDLGAKFAEKNEGYHFRAVREIQGHKPVEAVAGIILGIITSILFAYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MY0</accession>
    <name>Q73MY0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971982.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678958.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1376"/>
    <dbReference type="EnsemblBacteria" id="AAS11893">
        <property type="protein sequence ID" value="AAS11893"/>
        <property type="gene ID" value="TDE_1376"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1376"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1321"/>
    <dbReference type="eggNOG" id="ENOG5030VVB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1864270_0_0_12"/>
    <dbReference type="OrthoDB" id="2127998at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="137" mass="16177" checksum="B63EE23B68BCB93C" modified="2004-07-05" version="1">MFIIEILVPIFLLVWSISSFLGYLYTRYLIDKYDRAVLPGCRIKAQKYQWSSKKVWEDSFTLLSGLWLKFFCIFAPISLSIDSLWLFLKSFRLYISIAGGLFFLIFMIIFMIKGIKIHKSFCSKGWFWTSYNTGKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MY2</accession>
    <name>Q73MY2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971980.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1374"/>
    <dbReference type="EnsemblBacteria" id="AAS11891">
        <property type="protein sequence ID" value="AAS11891"/>
        <property type="gene ID" value="TDE_1374"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1374"/>
    <dbReference type="HOGENOM" id="CLU_3376602_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="34" mass="4146" checksum="531B52CC6D017F6D" modified="2004-07-05" version="1">MLIVEFFKVLFTLPVEAGLRFYFHNRITAECRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N03</accession>
    <name>Q73N03_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidoglycan glycosyltransferase RodA</fullName>
            <shortName evidence="6">PGT</shortName>
            <ecNumber evidence="6">2.4.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cell elongation protein RodA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Cell wall polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Peptidoglycan polymerase</fullName>
            <shortName evidence="6">PG polymerase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">rodA</name>
        <name evidence="7" type="ordered locus">TDE_1353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Peptidoglycan polymerase that is essential for cell wall elongation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SEDS family. MrdB/RodA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="6"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971959.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677908.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1353"/>
    <dbReference type="EnsemblBacteria" id="AAS11870">
        <property type="protein sequence ID" value="AAS11870"/>
        <property type="gene ID" value="TDE_1353"/>
    </dbReference>
    <dbReference type="GeneID" id="2739454"/>
    <dbReference type="KEGG" id="tde:TDE_1353"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1301"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_2_2_12"/>
    <dbReference type="OMA" id="IFCTVGE"/>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02079">
        <property type="entry name" value="PGT_RodA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="433" mass="49257" checksum="31140960EA7ED81E" modified="2004-07-05" version="1">MNIRKITNFDYLLFLAVVLLSFIGVLFIYSSGINSAGELVSKEYVKQILWVCTGIVLLLLSCIYDYRRIKDRTFLIYLVGMILLLYTGIFGTVRHNARSWIGLKNLGIQPSEFIKLIFILFLAYYLDKSQNEEPLKRFIKAIAIMIVPVALILKQPDLGTASVYIPIFLIMCFIAGIPLRFILYVFFLGVLTIVFTLMPLWEEIILKTSHVMTNILKNSQVSIIILFAMGISTVIAMIGNVLLKRRYYYWIAYVLSLITLAFAGSIVGVRALKEYQMMRLIIFLDPEVDPLKHGWNIIQSITAIGSGGFMGRGYLMGTQSHYRYLPEQSTDFIFSILSEEWGFLGGIFVFFLYSIVFFRFFLSIKRCDDLFGKLIVSGILAMFFFHFFVNVGMVMGIMPITGIPLLFLSYGGSSLWTAMISVGVVIGINLRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N47</accession>
    <name>Q73N47_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Modulator of DNA gyrase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971915.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678842.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1309"/>
    <dbReference type="EnsemblBacteria" id="AAS11826">
        <property type="protein sequence ID" value="AAS11826"/>
        <property type="gene ID" value="TDE_1309"/>
    </dbReference>
    <dbReference type="GeneID" id="2739567"/>
    <dbReference type="KEGG" id="tde:TDE_1309"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1258"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_1_12"/>
    <dbReference type="OMA" id="YTRMTNT"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="240"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="475" mass="53433" checksum="626083F04A44115C" modified="2004-07-05" version="1">MKQKMSKFLTDSKPVLKKLIEELSKEFEYVSILGSDSKGKSYSVRKTAVSVGDSFSTERGFVLRVYNGLGYSEYSFDVIDAENIKKEIRRIAKTDIEFLKSKNLERIKYPVIEEESLTKSFYAEVKESFDSMNDEQKIKRLESVMKKGFDYCPEMIDFQVRYEEVSVCKIFLSQKKDLEQAYAYAISYLSPYLKKGESVKYSFQDFSGNCGMEILHKVEDNIKKSIDATKELLDAERIKPGVYDIICKQNVTGLIAHEAFGHGVEMDMFVKNRAKAKEFIGKKVASEITDMHDGAAAAEQVSSYLFDDEGVLAQDTQIIEKGILKRGICDTLSALSLGIKPTGNGKRESFERKAYTRMTNTFFSTKNSSLDEMIKSVDFGYLLDGYFSGMEDPKNWGIQCAVEKGYEIKDGKLTGKIVGPIFLTGYVPELLSSISMISGEEDFELEGSGFCGKGYKEYVRTSAGGGYIKARGRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N64</accession>
    <name>Q73N64_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971898.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678795.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1291"/>
    <dbReference type="EnsemblBacteria" id="AAS11809">
        <property type="protein sequence ID" value="AAS11809"/>
        <property type="gene ID" value="TDE_1291"/>
    </dbReference>
    <dbReference type="GeneID" id="2741045"/>
    <dbReference type="KEGG" id="tde:TDE_1291"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1240"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335392_0_0_12"/>
    <dbReference type="OMA" id="HAFMIQD"/>
    <dbReference type="OrthoDB" id="1740924at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="19"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="191" mass="21979" checksum="1A3DDC78F45E9D20" modified="2004-07-05" version="1">MLPSKEEAERLLEEAYLKNPGPWREHSIVAAKCAQKIASACKDLDPVKAYILGLLHDIGRREGVTALAHVIDGYEYLMKLGYDEAARVCITHSFSIKKIETYIGKNDVSPEAYKKIKKLIDEYEYDDYDRLIQLCDSIALPQGSAKIEERMGDVKKRHGYYPQDKWNKHIELKKYFEQKSGLEIDELGIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N92</accession>
    <name>Q73N92_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn_dep_PLPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971870.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1263"/>
    <dbReference type="EnsemblBacteria" id="AAS11781">
        <property type="protein sequence ID" value="AAS11781"/>
        <property type="gene ID" value="TDE_1263"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1263"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1214"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064046_1_0_12"/>
    <dbReference type="OrthoDB" id="733534at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_dep_PLPC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="250" mass="29153" checksum="4853CCC32A09EDFC" modified="2004-07-05" version="1">MSPEIVAEISNKNLYNLGLQGPDFLYFYKPFKKNNNPVLQLAKDIHNKNCTDVFNAVLNKIRIEPNTDEFSYMMGFIGHFGLDSCCHPYVNAMVEEMKRDHAEIEMEFEKFLLKQDGLHPLRYKAHNYIDISEKEAEAVANIYRCLLPSITKEDILRSFHSFKMGKHFFYAPTKLSQSLKLSLIKILGLYDFLQGHIIRTADHIKSKITNKKLFSLYNNSIEITAELMENFYKNLTENKPLLDRFGYNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73N95</accession>
    <name>Q73N95_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cholinephosphate cytidylyltransferase/choline kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971867.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1260"/>
    <dbReference type="EnsemblBacteria" id="AAS11778">
        <property type="protein sequence ID" value="AAS11778"/>
        <property type="gene ID" value="TDE_1260"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1260"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1212"/>
    <dbReference type="eggNOG" id="COG0510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_467630_0_0_12"/>
    <dbReference type="OMA" id="YKWTGTM"/>
    <dbReference type="OrthoDB" id="1603998at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017190">
        <property type="entry name" value="Bifunc_CCT/choline_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037383">
        <property type="entry name" value="LicCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="522" mass="61616" checksum="725C6DC402D21D26" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-23" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NB9</accession>
    <name>TPIS_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Triosephosphate isomerase</fullName>
            <shortName evidence="1">TIM</shortName>
            <shortName evidence="1">TPI</shortName>
            <ecNumber evidence="1">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tpiA</name>
        <name type="ordered locus">TDE_1236</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971843.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678731.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NB9"/>
    <dbReference type="SMR" id="Q73NB9"/>
    <dbReference type="STRING" id="243275.TDE_1236"/>
    <dbReference type="EnsemblBacteria" id="AAS11754">
        <property type="protein sequence ID" value="AAS11754"/>
        <property type="gene ID" value="TDE_1236"/>
    </dbReference>
    <dbReference type="GeneID" id="2741178"/>
    <dbReference type="KEGG" id="tde:TDE_1236"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1189"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_12"/>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="OrthoDB" id="1266295at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000307593" description="Triosephosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <sequence length="250" mass="27034" checksum="015FB5A14DDEB1B6" modified="2004-07-05" version="1">MKKFYIAANWKMNMNRAEAKQLATEMKAGLKDGKNKYMIAPSFTLLQDVASVLKGSNILLGAQNMGLEEKGAHTGEVSVLQLLDVGVQAVILGHSERRHIYKETDDLINKKVKLALKHGLEVILCVGELLEEREAGHAEAVCERQIKKGLAEVSAKDLDKVTIAYEPVWAIGTGKNASPEDADAIHSSIRKTLAALYGEKAAKNMIIQYGGSMKPENAAGLLKKHNIDGGLIGGAGLKTETFLPIALFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NC5</accession>
    <name>Q73NC5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971837.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1230"/>
    <dbReference type="EnsemblBacteria" id="AAS11748">
        <property type="protein sequence ID" value="AAS11748"/>
        <property type="gene ID" value="TDE_1230"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1230"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1185"/>
    <dbReference type="HOGENOM" id="CLU_2060409_0_0_12"/>
    <dbReference type="OrthoDB" id="2002282at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="119" mass="13677" checksum="F4DB357AA30122F7" modified="2004-07-05" version="1">MIQSLVSFPFRKTIPLFKTKKKFDYLTIYPPILSGSLIVRPCNSPDSFEVNGGFILGDAREEAKTVFLQLESLKQKTRLPVFSILSCRSRYYADVEFEEEKSGLCTCKIKNKVWQKTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NG6</accession>
    <name>Q73NG6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971794.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682437.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1186"/>
    <dbReference type="EnsemblBacteria" id="AAS11705">
        <property type="protein sequence ID" value="AAS11705"/>
        <property type="gene ID" value="TDE_1186"/>
    </dbReference>
    <dbReference type="GeneID" id="2740083"/>
    <dbReference type="KEGG" id="tde:TDE_1186"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1142"/>
    <dbReference type="eggNOG" id="ENOG5031CWX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1601968_0_0_12"/>
    <dbReference type="OrthoDB" id="1956656at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284609" evidence="1">
        <location>
            <begin position="21"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="166" mass="19553" checksum="39A0334D0A96B764" modified="2004-07-05" version="1">MLKKYISCILFFIFFGLAFADTAAFACFQNKDAHEKCRNITEIFEDNLFDKFFDEGFIATSIPISEVKSEEEISLTSIKAFFEECPNYLIIFYMQYGTELLFNEKKQLKEADWQKMTVRMLDCASEKEIYKKTIDITKLKEKDVEKKAEKMADQISKEIFEAISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NI6</accession>
    <name>Q73NI6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971774.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956912.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1166"/>
    <dbReference type="EnsemblBacteria" id="AAS11655">
        <property type="protein sequence ID" value="AAS11655"/>
        <property type="gene ID" value="TDE_1166"/>
    </dbReference>
    <dbReference type="GeneID" id="2741498"/>
    <dbReference type="KEGG" id="tde:TDE_1166"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1125"/>
    <dbReference type="HOGENOM" id="CLU_2208881_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="107" mass="12710" checksum="903AA749B9C1300A" modified="2004-07-05" version="1">MKRQINYYRKQVDYKNIHTHGEIMEAVIFNTPELTYKYHIFILHNGKQTEKLYRRSLSGAKKSAYKQLQIPQKNGQAMLIEKAKPVFIRIDGRKVEVPEYMEIPIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NK3</accession>
    <name>Q73NK3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971757.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956896.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1149"/>
    <dbReference type="EnsemblBacteria" id="AAS11638">
        <property type="protein sequence ID" value="AAS11638"/>
        <property type="gene ID" value="TDE_1149"/>
    </dbReference>
    <dbReference type="GeneID" id="2741481"/>
    <dbReference type="KEGG" id="tde:TDE_1149"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1108"/>
    <dbReference type="eggNOG" id="ENOG502Z83C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_841637_0_0_12"/>
    <dbReference type="OMA" id="DNTSIWL"/>
    <dbReference type="OrthoDB" id="1296608at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="320" mass="35397" checksum="99F47028E97A7EBD" modified="2004-07-05" version="1">MPNLSMTDSMTALEVMRRANNQDGFHIVELMAQTNEILKDMPMIEANDGTIHNTLVRTSLRSGTHRKYNEGIAPGATTTDTIRDRITMLEDYSIVDKDLADHSGNVKALRASEADAFLQGMGQTQAEELIYGDHGRNEAEINGLAVRLNKLTNKNVINAGGSGNKCTSIYVCAIGNRFAHLIYPRGRKDCGIKTEDMGLQNWPMEQGKVMPAYVQFFSTHYGLSIAHPDAVKRICNIDNTVPGDKIVEMILEAMLRLPQGAQGVSIYCNQDILVKIDKAAWSKGNAVFTKEDPWGDMITHIRSGRCRRVDAILSTEQALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NK9</accession>
    <name>Q73NK9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971751.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956890.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1143"/>
    <dbReference type="EnsemblBacteria" id="AAS11632">
        <property type="protein sequence ID" value="AAS11632"/>
        <property type="gene ID" value="TDE_1143"/>
    </dbReference>
    <dbReference type="GeneID" id="2740002"/>
    <dbReference type="KEGG" id="tde:TDE_1143"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1102"/>
    <dbReference type="HOGENOM" id="CLU_367195_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="759" mass="86531" checksum="97FF99A331873CD6" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NN2</accession>
    <name>Q73NN2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971728.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682418.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1120"/>
    <dbReference type="EnsemblBacteria" id="AAS11609">
        <property type="protein sequence ID" value="AAS11609"/>
        <property type="gene ID" value="TDE_1120"/>
    </dbReference>
    <dbReference type="GeneID" id="2739536"/>
    <dbReference type="KEGG" id="tde:TDE_1120"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1080"/>
    <dbReference type="eggNOG" id="ENOG5032JS6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_997273_0_0_12"/>
    <dbReference type="OrthoDB" id="969245at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="273" mass="31455" checksum="05386FCF373B02B5" modified="2004-07-05" version="1">MNKALNRIEYEYIVDTFIREKPSLSLLCKNTFLKIDSSSYKLIDDYIFFKADGVEVSDDIKVFFNHKKRPLYFFSRVEQKEGITVFKLSDKFYKHDDELKNCQISLWNSGGFKLKAGISSDFPLSFPYPPAVDDEDSEVFFGLCSKISGLMKLDADKIPEAFFYRLYDIAIKHRAPDFSPCLLYIDAEFILIFCIEEKAKEIASQISAQMEVGFSRRKVKCSSIFSFFLPNLNVNSTGESCGALCLTIKNIHEEDKRFLHEKAHASKYGYPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NW9</accession>
    <name>Q73NW9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PolyA polymerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_1033</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971641.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682344.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1033"/>
    <dbReference type="EnsemblBacteria" id="AAS11522">
        <property type="protein sequence ID" value="AAS11522"/>
        <property type="gene ID" value="TDE_1033"/>
    </dbReference>
    <dbReference type="GeneID" id="2741511"/>
    <dbReference type="KEGG" id="tde:TDE_1033"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.993"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_3_1_12"/>
    <dbReference type="OMA" id="GWTFHGH"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032810">
        <property type="entry name" value="CCA-adding_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13735">
        <property type="entry name" value="tRNA_NucTran2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol" evidence="6">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="7">
        <location>
            <begin position="171"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTran2_2" evidence="8">
        <location>
            <begin position="297"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="448" mass="50173" checksum="84570F9BB3430971" modified="2004-07-05" version="1">MRYPVSKKMSEIASVFFNAGFSAYLVGGAVRDWFLGKPCKDYDIATDAEPKEVQALFRKTIPTGIAHGTVTILYKDEKIECTTFRCEADYSDGRRPQSVNYVRSIEEDLSRRDFTMNAIAVSLKDGSIVDPFDGVKSIKSKTIKTVGSPLDRFGEDGLRPIRAIRFASQLGFKIEEETLKAIPLSIEVCKKVSIERFRDEFVKMLLSEHPIISLKLLEDTGLLKVFLPELSDCRGVEQKGMHSFDVLDHSFLSCDAAPQDNPIVRLAALFHDIGKVSTREKNEYGDYTFYKHEAVSEKLTKKIMQRLKFPNKEIEEVSHLVGLHMFHYTEDWTDAAVRRFIVRAGVENIPNLFDLRRADGFGMTGQAPDLSNLAAFKKRLEKVIAEDSALSLKDLAVGGRELMEIGIPAGPKLGIILQKLFEAVLEDPSQNTKAQLLKIAAAINSNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P86</accession>
    <name>Q73P86_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971523.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682207.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0913"/>
    <dbReference type="EnsemblBacteria" id="AAS11404">
        <property type="protein sequence ID" value="AAS11404"/>
        <property type="gene ID" value="TDE_0913"/>
    </dbReference>
    <dbReference type="GeneID" id="2739953"/>
    <dbReference type="KEGG" id="tde:TDE_0913"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.883"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043522_0_0_12"/>
    <dbReference type="OMA" id="KANRVCR"/>
    <dbReference type="OrthoDB" id="1749331at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="452" mass="53060" checksum="BD4D922F82E99CDF" modified="2004-07-05" version="1">MNSTNSFDDKLVLNIYTVDGDHQLLIDNNKAGFEFYLELMEVFADVDAVNHKINIKSPLCMSNEIKNRMFNFSQEKSKIKPEIQKLNKIIKDIPNNQFFIIIPYLLMDPLEILKIFEYLKCINNNASEEIFKEKIVKLEKDYTDSFAELEKKYEFIMFSTRIQNVIGEKDRTKRVCRYCGRSAADGTTFKEKAHAISESIGNKIFICTEECDACNSRFAGTIEKDFFELIKLYRTIYGSKGKNGIPTLHYRDGITIEYDKKKNCPIIRHRTDKPAVNEKGDLHLKLESDTNVNPMNIYRCLVKFALGLIDNSELSKFIKTVEWINNIKNDGSTINLPPVMCFLDRQNYFEQPEIVLYTRKTDDKKYPYLYAELKTCMFIFVFIVPFCLEDSTDFGNKKNFKVFWDLNKQYRLLNRKWVEYYLNTDLAQSFRYNFSILAGRDNSESNKDIDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PE1</accession>
    <name>Q73PE1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971468.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670162.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0858"/>
    <dbReference type="EnsemblBacteria" id="AAS11349">
        <property type="protein sequence ID" value="AAS11349"/>
        <property type="gene ID" value="TDE_0858"/>
    </dbReference>
    <dbReference type="GeneID" id="2741369"/>
    <dbReference type="KEGG" id="tde:TDE_0858"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.827"/>
    <dbReference type="eggNOG" id="ENOG5030RR9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1427426_0_0_12"/>
    <dbReference type="OrthoDB" id="1854169at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="190" mass="21956" checksum="F2608D28C0B857C3" modified="2004-07-05" version="1">MSDDDLFEKRDSSPREVFTRYNREDRIKNASEKVRQLHDPDFVRKRSFIKSVTENRGLRSVFFVIVVLVSINIAFFITRSDRNSGRIYGIKTELKSFIYQDRALANLRLSENTKFLESLKESEEKDGALVRVNFIFLDDKGNKLSSSLQTGIYTGGELRFSSQNESGNAKKVQAEIYIKEKLLVLLSKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PG5</accession>
    <name>Q73PG5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na(+)-translocating NADH-quinone reductase, E subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nqrE</name>
        <name evidence="8" type="ordered locus">TDE_0834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971444.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670118.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0834"/>
    <dbReference type="EnsemblBacteria" id="AAS11325">
        <property type="protein sequence ID" value="AAS11325"/>
        <property type="gene ID" value="TDE_0834"/>
    </dbReference>
    <dbReference type="GeneID" id="2739518"/>
    <dbReference type="KEGG" id="tde:TDE_0834"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.803"/>
    <dbReference type="eggNOG" id="COG4657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095255_1_0_12"/>
    <dbReference type="OMA" id="CPFFGVS"/>
    <dbReference type="OrthoDB" id="1814639at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="190" mass="20550" checksum="D445C26BE9349289" modified="2004-07-05" version="1">MPETLSIFLSAILVKNVVLMRFLALCPFIGMSSDVKKSVGMGWAVLFVTLLATAVTYPIYNYVLIGNLEFLQTLIFILVIASLVQLVEFYLKKAAPALYSSMGVYLALITTNCAILAVTIDAIDEGYTFVQALVHAAGSAFGFMISLLLLAGLRQRIDNAPVPKFLKGTPILFIAAALLSMAFEGFKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PJ2</accession>
    <name>Q73PJ2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971417.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682065.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0807"/>
    <dbReference type="EnsemblBacteria" id="AAS11298">
        <property type="protein sequence ID" value="AAS11298"/>
        <property type="gene ID" value="TDE_0807"/>
    </dbReference>
    <dbReference type="GeneID" id="2739549"/>
    <dbReference type="KEGG" id="tde:TDE_0807"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.779"/>
    <dbReference type="HOGENOM" id="CLU_2884598_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="61" mass="7119" checksum="9D41771097DF4D83" modified="2004-07-05" version="1">MIDFLNLYFLKNFSSNALDKELIIPDTLLEIEFFGNNIFLSTQLPLLTQKKLKQMGYTGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PK1</accession>
    <name>Q73PK1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0798</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971408.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682053.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0798"/>
    <dbReference type="EnsemblBacteria" id="AAS11289">
        <property type="protein sequence ID" value="AAS11289"/>
        <property type="gene ID" value="TDE_0798"/>
    </dbReference>
    <dbReference type="GeneID" id="2740676"/>
    <dbReference type="KEGG" id="tde:TDE_0798"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.771"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038661_0_0_12"/>
    <dbReference type="OMA" id="PMVVDMT"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="442" mass="49027" checksum="831978DD4796DFD0" modified="2004-07-05" version="1">MKQKEGFRKYLPITFLIGAGFFTMGLMDPLYDSYVTIFLSRYIPFKWLVGILMSIDNVLAILLIPIVSAWSDRTRTKIGRRMPWIITLLPLSAITFSFIPYAAKNSLAALIIILALLNLFKQSVRGPVIALMPDIVPAEFRSQGNGVINTMGNIAAIVGTLFLARLMDVDTVLPIIGHTKDVLSFPAAGLLVILATLMLFFFVKEKNAPLHDSSENEEEKKVPFIQAMKTVLAGRKIEDEEKPDKSALFVLVSLFLWFLGYQGMLPYIAEYSIKHFGVSTGQGAFAAGMVGIASALSAIPMGYAASKWGRKRMIRIALVVVASLCLAQFFLIEIAGILGLAEGQIKYLFWGLMFVFGIFWICIIANSFPMLWQMAGFSHIGLYTGLYYTFSQGAAILAPFLAGLIIDFAGHRAVFVYCACFFLLAWLMMGKVTRGEKYDKVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PL8</accession>
    <name>RS8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsH</name>
        <name type="ordered locus">TDE_0781</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971391.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670022.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PL8"/>
    <dbReference type="SMR" id="Q73PL8"/>
    <dbReference type="STRING" id="243275.TDE_0781"/>
    <dbReference type="EnsemblBacteria" id="AAS11272">
        <property type="protein sequence ID" value="AAS11272"/>
        <property type="gene ID" value="TDE_0781"/>
    </dbReference>
    <dbReference type="GeneID" id="2740659"/>
    <dbReference type="KEGG" id="tde:TDE_0781"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.754"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_0_2_12"/>
    <dbReference type="OMA" id="FDQGYIL"/>
    <dbReference type="OrthoDB" id="1692188at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000126514" description="30S ribosomal protein S8">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <sequence length="132" mass="14426" checksum="70F503C2983065BD" modified="2004-07-05" version="1">MSVSDPIADMLTKIRNAASAGHESVDVPSSKMKWEIISILKSEGYIKNFKKMTQEGAGNIRVFLKYDDKESSVIHGIERVSTPGRRVYLGYKSLPRVFNGYGTLIVSTSKGIITGKAAGESQVGGELICKVW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PN2</accession>
    <name>RS10_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsJ</name>
        <name type="ordered locus">TDE_0766</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971376.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669994.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PN2"/>
    <dbReference type="SMR" id="Q73PN2"/>
    <dbReference type="STRING" id="243275.TDE_0766"/>
    <dbReference type="EnsemblBacteria" id="AAS11257">
        <property type="protein sequence ID" value="AAS11257"/>
        <property type="gene ID" value="TDE_0766"/>
    </dbReference>
    <dbReference type="GeneID" id="2740306"/>
    <dbReference type="KEGG" id="tde:TDE_0766"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.739"/>
    <dbReference type="eggNOG" id="COG0051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_1_3_12"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="OrthoDB" id="2012682at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000146623" description="30S ribosomal protein S10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <sequence length="102" mass="11433" checksum="6F0F0464D0965E37" modified="2004-07-05" version="1">MTKEKIRVKLRGFDVELVDQSSKAIVQAVQKAGAKVCGPIPLPTRINKFTVLRSPHVNKKSREQFEMRTHKRLIDIIEPSAEVMNALLALELSAGVDVEIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PR6</accession>
    <name>Q73PR6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971342.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681971.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0730"/>
    <dbReference type="EnsemblBacteria" id="AAS11223">
        <property type="protein sequence ID" value="AAS11223"/>
        <property type="gene ID" value="TDE_0730"/>
    </dbReference>
    <dbReference type="GeneID" id="2740094"/>
    <dbReference type="KEGG" id="tde:TDE_0730"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.706"/>
    <dbReference type="eggNOG" id="ENOG50342TQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587848_0_0_12"/>
    <dbReference type="OrthoDB" id="8092at157"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284625" evidence="1">
        <location>
            <begin position="24"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="463" mass="52521" checksum="EEDD9612E5E6A7E1" modified="2004-07-05" version="1">MLKKQLLKKLLLLILTLILFSCASYKNKPEDEVPVWIEKVPAGNADYEYFTASGTNKNFTLAEADAKNNLINEIIRYLGVSIKTETTTTALGSIENLEKILKSEISQSSAANIKKLKIKNRYTKKNKDSLTVYLLAEYDKNELRKERDRLLKIAEEKILSVSEPQKKADEFVESKKYYSAALYYTKAASAALSSGIENGDIKFRQNISNAKESLKKIKLNLQKDNLENTSNEFLIPINIGTFEERVPLLVSYKTKVKNTTSIIIEGIETDQNGTANFILHDEKIEPKARIRIELDISEIKQILGSKDFDEYQEAVKELQQIVFKQIINFEFKKPENKIKKEQKGTVSLFIEQADSKNSIIEEKILDILKDMNFKTISAKNENPAADFFIYAKIETDEASKAADGFLVRLNADIEIKNPNTQEIFYKKNISKRGAGFTEKEAHRSASIAIAKAIVLAFSKIVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PT2</accession>
    <name>Q73PT2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Capsular polysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971326.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681937.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0714"/>
    <dbReference type="EnsemblBacteria" id="AAS11207">
        <property type="protein sequence ID" value="AAS11207"/>
        <property type="gene ID" value="TDE_0714"/>
    </dbReference>
    <dbReference type="GeneID" id="2740621"/>
    <dbReference type="KEGG" id="tde:TDE_0714"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.691"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013560_5_2_12"/>
    <dbReference type="OMA" id="IIIAMPS"/>
    <dbReference type="OrthoDB" id="662797at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="151"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="495" mass="55584" checksum="8922C357422D53C1" modified="2004-07-05" version="1">MNRPIKQKTSIYIVGAGLAGTMIAHEISEKNIFGKVAAFLDDDPKKIGTKIDGIPVFGPISETVHLIRIDAGDEALIAIPSMRSERLREIYELLKSAGFSKIKLLPAISQIIDGSAHLVQAREIDPQDLLTRTPVTISLKKSLAYLRGKRVLITGAGGSIGSELCRQLLSGGAERLYLFGHGENSIYQIYKELKILQAGGVGDKATIVPVIGELKDREYMRYIIKQLKCDAVFHTAAYKHVPLMEENPVAVIENNVFGTKNLLDACIEFGVKRFVLISTDKAVEPVSVYGVSKLLSEKLVLQAAETVKEKKDSAYMFVRFGNVLGSRGSIFPLFVEQIQNGGPVTVTDKKMIRFFMTIPEACSLVLQTGGVGKSGESYLLDMGEPVNIYETAKQLISYMGFEPEKDIKIEIIGPREGERLEEPLWSSTEYLEKTDYEKIMRLRDKKEFDSKNLNEILNTLYPFCFYSEEHKDDFRNKEKMRNFLEENKLLIYKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PZ1</accession>
    <name>Q73PZ1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, M20/M25/M40 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971267.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669899.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0654"/>
    <dbReference type="EnsemblBacteria" id="AAS11148">
        <property type="protein sequence ID" value="AAS11148"/>
        <property type="gene ID" value="TDE_0654"/>
    </dbReference>
    <dbReference type="GeneID" id="2739202"/>
    <dbReference type="KEGG" id="tde:TDE_0654"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.634"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_12"/>
    <dbReference type="OMA" id="EWHHPAF"/>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="187"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="390" mass="42727" checksum="6B59C7883A377435" modified="2004-07-05" version="1">MDILKKVKEIEKDIISWRRHLHQNPEVGFELPNTIDFVCKKLDEFGIKYDRNAAKSAVIGYIHGAEKGDVIALRADMDALPVCEATGLDFASKNSFMHACGHDAHTSILLGAAKVLNDLKGSFKGTVKLIFQPAEELGTGSVDICEKGILDDVKEIIGLHVGCISDEAKPGEFLFSKGSMMACMDKFSIKVKGVGAHGAYPSLSVDPVVIGSHIVVAIQEILGREVHPTEPAVITVGQFHSGSAFNIIPPEAYLEGTVRAVTNETRELIAKRIEEVASNIAKAFRGSIEYQFFRQPPPLINDAKVTDKAMGAAKELFPNDVKLMQRPVMGGEDFAWYLEKVPGSFIFLSTPSPIEGKVWPHHNPKFALDESQFYKGTALFVAYVMQELGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q05</accession>
    <name>Q73Q05_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide/dipeptide ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971253.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956792.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0639"/>
    <dbReference type="EnsemblBacteria" id="AAS11134">
        <property type="protein sequence ID" value="AAS11134"/>
        <property type="gene ID" value="TDE_0639"/>
    </dbReference>
    <dbReference type="GeneID" id="2739364"/>
    <dbReference type="KEGG" id="tde:TDE_0639"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.617"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_2_12"/>
    <dbReference type="OMA" id="FLMVNVM"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="96"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="313" mass="35330" checksum="4F8BD7511ACB5C54" modified="2004-07-05" version="1">MLNFILKRILYGILTMFIVASITFFLVHIIPGNPIETIAENLPEERRNELYSQYGYDKSLFTQYMVFWKNLLMKGDLGTSLYYRGRLVTDVIKTHAPISARLGLQALFFGVSVGLSLGILSAAKRGKKFDYAVILIAVIGISIPNFVLGQMLQYFFGIKHNLLPITGWGSFKYTVLPSLALAIGPIAKYSRYMRSNYLDIINQDYILTARAKGASKVRIIKSHILRNAFLPIITMLGPQIAFTFTGTFIIENIFSVPGLGSYFVRSISERDYTMVMGQTIFISFLYVASLIIVDIAYNLLDPRIKVQVKNEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q33</accession>
    <name>Q73Q33_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971225.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11106">
        <property type="protein sequence ID" value="AAS11106"/>
        <property type="gene ID" value="TDE_0611"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0611"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.591"/>
    <dbReference type="HOGENOM" id="CLU_3359072_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="36" mass="3833" checksum="EA4DD2DA37C3CD65" modified="2004-07-05" version="1">MKKQALFDVVLLLTLTGSVIGCNKGKDEKLGGILND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q56</accession>
    <name>HUTH_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine ammonia-lyase</fullName>
            <shortName evidence="1">Histidase</shortName>
            <ecNumber evidence="1">4.3.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hutH</name>
        <name type="ordered locus">TDE_0588</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-histidine = NH4(+) + trans-urocanate</text>
            <dbReference type="Rhea" id="RHEA:21232"/>
            <dbReference type="ChEBI" id="CHEBI:17771"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="EC" id="4.3.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.3" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971202.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681759.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73Q56"/>
    <dbReference type="SMR" id="Q73Q56"/>
    <dbReference type="STRING" id="243275.TDE_0588"/>
    <dbReference type="PRIDE" id="Q73Q56"/>
    <dbReference type="EnsemblBacteria" id="AAS11083">
        <property type="protein sequence ID" value="AAS11083"/>
        <property type="gene ID" value="TDE_0588"/>
    </dbReference>
    <dbReference type="GeneID" id="2741551"/>
    <dbReference type="KEGG" id="tde:TDE_0588"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.568"/>
    <dbReference type="eggNOG" id="COG2986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014801_4_0_12"/>
    <dbReference type="OMA" id="CAPQVAG"/>
    <dbReference type="OrthoDB" id="715502at2"/>
    <dbReference type="UniPathway" id="UPA00379">
        <property type="reaction ID" value="UER00549"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004397">
        <property type="term" value="F:histidine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019556">
        <property type="term" value="P:histidine catabolic process to glutamate and formamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019557">
        <property type="term" value="P:histidine catabolic process to glutamate and formate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00229">
        <property type="entry name" value="His_ammonia_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005921">
        <property type="entry name" value="HutH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="PTHR10362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01225">
        <property type="entry name" value="hutH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0369">Histidine metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000161045" description="Histidine ammonia-lyase">
        <location>
            <begin position="1"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="modified residue" description="2,3-didehydroalanine (Ser)" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="cross-link" description="5-imidazolinone (Ala-Gly)" evidence="1">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00229"/>
        </source>
    </evidence>
    <sequence length="507" mass="54038" checksum="8269DC8F8F84863C" modified="2004-07-05" version="1">MKVKPVTVTGSSLTIEDVVAVARHGAEVKLSADAKKRIKDSKKIVDDIVKSGKPTYGISTGFGELSTVTITKDQNGALQRNLILSHACGVGNPFPEDIVRAIMLLRLNTHASGFSGVTPSVPDILVDMLNKGVIPYVPEKGSLGASGDLANLAHIALVMIGEGKAYYEGKLMEGKAALAKAGLKPVVLSGKDGLGIINGTPVMSGIGALALHDAEQLLKAANMGASLVFEAFRGITAALDPRIHKSRPHKGQIDTAAFILKMLKGSSSINTRENDVQDPYTLRCVPQVHGASADAIAYVRKVLEIEINAVTDNPLVFPDNHDVISGGNFHGQPIAITMDFLGIAVSELANISERRIERLVNPQLNGGLPAFLIENGGVNSGFMIPQYTAASLVSENKVLAHPASVDSITSSGNKEDHVSMGTTAARKITEIVKNVRHVLAIEWLTAAQACDLRGVKKYGKGTGEMMKLIRKHISKVTEDRILYNDIMKALEIISNDENIDMIENAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q73</accession>
    <name>Q73Q73_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4469 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971184.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681739.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0570"/>
    <dbReference type="EnsemblBacteria" id="AAS11065">
        <property type="protein sequence ID" value="AAS11065"/>
        <property type="gene ID" value="TDE_0570"/>
    </dbReference>
    <dbReference type="GeneID" id="2741006"/>
    <dbReference type="KEGG" id="tde:TDE_0570"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.554"/>
    <dbReference type="eggNOG" id="ENOG503295Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092785_0_0_12"/>
    <dbReference type="OMA" id="CAKGTAN"/>
    <dbReference type="OrthoDB" id="1207078at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd12843">
        <property type="entry name" value="Bvu_2165_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027824">
        <property type="entry name" value="DUF4469"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14734">
        <property type="entry name" value="DUF4469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4469" evidence="1">
        <location>
            <begin position="130"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="235" mass="25613" checksum="47E8FAFA03A364E7" modified="2004-07-05" version="1">MLKYCLRENLLTPAPDDYMAQVTDSQVFTLEDVIDRMVKRGTTVTRTDLVAIMQLYTQECSFIVEEGGTLNTPLINTSMSISGVFDGADDAFDKKRHTVNLNINAGTALKTAVGKVKTIKTETASTDPYITSVLDKLNGSSDEVKIGSVMEIIGSRLKFDPKDDEQGVFAVSGTKTVRCASVVENKPARIIVLLDASVPAGDFTLEVRTKLSSDGSKKSKTLKKGYYRKTLKAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QB4</accession>
    <name>Q73QB4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971143.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681667.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0529"/>
    <dbReference type="EnsemblBacteria" id="AAS11024">
        <property type="protein sequence ID" value="AAS11024"/>
        <property type="gene ID" value="TDE_0529"/>
    </dbReference>
    <dbReference type="GeneID" id="2741748"/>
    <dbReference type="KEGG" id="tde:TDE_0529"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.515"/>
    <dbReference type="eggNOG" id="ENOG503338M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1601971_0_0_12"/>
    <dbReference type="OMA" id="VFCITIH"/>
    <dbReference type="OrthoDB" id="1636336at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="166" mass="19338" checksum="302A399D9C6BF66F" modified="2004-07-05" version="1">MNKIVTTTVMVIFTLLIFTADIVLITRFFTLIKQRRYNDSAPLWGGLPDLFSKIENKYLKTFLNYIILNIAVYIIGYYFPKTGVFTGTLKFSFDIVIEGYRFLVSFIITNLFLAISQLTRKIKIFQQNTVSAKLYYIELIIIPIIVIFSLYFFDSVFDNLAMKVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QC7</accession>
    <name>Q73QC7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971130.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002665898.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0516"/>
    <dbReference type="EnsemblBacteria" id="AAS11011">
        <property type="protein sequence ID" value="AAS11011"/>
        <property type="gene ID" value="TDE_0516"/>
    </dbReference>
    <dbReference type="GeneID" id="2739253"/>
    <dbReference type="KEGG" id="tde:TDE_0516"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.502"/>
    <dbReference type="eggNOG" id="ENOG5032T15">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2246468_0_0_12"/>
    <dbReference type="OrthoDB" id="1941838at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="104" mass="12129" checksum="3BFF01A378CBCC3F" modified="2004-07-05" version="1">MDNINLLHLKQRLDSIDWSGNFEQADKEHYETLDSLCEYIEVELGRNPKSETIDNALLLLAENIGCAEDFTRYEENFVNKLADKGLLTKERTKLFYNNTSRRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QL8</accession>
    <name>Q73QL8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bacteriocin ABC transporter, ATP-binding/permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">TDE_0425</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971039.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681480.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0425"/>
    <dbReference type="MEROPS" id="C39.001"/>
    <dbReference type="EnsemblBacteria" id="AAS10920">
        <property type="protein sequence ID" value="AAS10920"/>
        <property type="gene ID" value="TDE_0425"/>
    </dbReference>
    <dbReference type="GeneID" id="2739589"/>
    <dbReference type="KEGG" id="tde:TDE_0425"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.412"/>
    <dbReference type="eggNOG" id="COG2274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_12"/>
    <dbReference type="OMA" id="QQSHFIE"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043214">
        <property type="term" value="F:ABC-type bacteriocin transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005897">
        <property type="entry name" value="Pept_C39_ABC_bacteriocin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03412">
        <property type="entry name" value="Peptidase_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01193">
        <property type="entry name" value="bacteriocin_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C39" evidence="10">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="169"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="482"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="515"/>
            <end position="522"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAS10920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="721" mass="79910" checksum="34EC57660952CD18" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QM3</accession>
    <name>Q73QM3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971034.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956738.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0420"/>
    <dbReference type="EnsemblBacteria" id="AAS10915">
        <property type="protein sequence ID" value="AAS10915"/>
        <property type="gene ID" value="TDE_0420"/>
    </dbReference>
    <dbReference type="GeneID" id="2739061"/>
    <dbReference type="KEGG" id="tde:TDE_0420"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.407"/>
    <dbReference type="HOGENOM" id="CLU_049884_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010103">
        <property type="entry name" value="Clustered_lipoprot_TREDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09710">
        <property type="entry name" value="Trep_dent_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01781">
        <property type="entry name" value="Trep_dent_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="395" mass="46518" checksum="D97D64085B8BC575" modified="2004-07-05" version="1">MKLKISLIILAGILLFSCSKEIKESAEERKSVVTNDVTEEEPPIVLTDENTPKTELIKLLESKKRHAWSLHKIQLEIDMYDVHGNSYEEFEKSGIDYLNRQKNTEIVKVDSDNKTIYCKQTLNLPSGKELIYDVVYTFYPYPKNFAYTNYALREKPVIADRQVQGSKKLHGKITEAEKDINKDKNIKIFERYINKYTKEYRHKTGDKPYKVLDYVKGNFSNSGKDEYIVLFTAPFTKSELEDGIFLLEYSYIKYVECFIMENDKVIKMYKLPGHWGHVVPREKTKIDLGEQFSFGWIADFNQNGRNEIFVHRKEVFGSSFFSIEFIDNRFVEIPITNRGDILKSVDWEQSKIVVETNPFRSLVLDSKDTRPKYFAEYQWCEKEHCYVLLSNKQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QM8</accession>
    <name>Q73QM8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971029.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956735.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0415"/>
    <dbReference type="EnsemblBacteria" id="AAS10910">
        <property type="protein sequence ID" value="AAS10910"/>
        <property type="gene ID" value="TDE_0415"/>
    </dbReference>
    <dbReference type="GeneID" id="2739056"/>
    <dbReference type="KEGG" id="tde:TDE_0415"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.402"/>
    <dbReference type="HOGENOM" id="CLU_049884_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010103">
        <property type="entry name" value="Clustered_lipoprot_TREDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09710">
        <property type="entry name" value="Trep_dent_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01781">
        <property type="entry name" value="Trep_dent_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284656" evidence="2">
        <location>
            <begin position="26"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="422" mass="50470" checksum="B626905918162A67" modified="2004-07-05" version="1">MKKNKSKLIFILMLAVLLFSCSKEVKEQKLVEAKVESSIKIEPKENEFLSKPEYNTHVKSPEQIKELEEKYKRSKAYEESLKQLRTELDKKEDILRYKCPVFMSIDNLAQQKASALYSHADNLDFIHFYEVKKDGEFCYCKYKAPTQNGGILDYQVTYKWYNIEQMYLPLSYDLLSETNMVKINDELIENQVHGSLYGMENDEKKDEMIKLFEDYENTRYPLYLEVVNTDWDTGVKTKKYKQYDMRILDYVKGNFTNSGYDEYFVMFYEEDPDPEIYDQFIERVRCFVVDEDKIIKDYYITVPSASFFPPHIERGGLFGLKNFGFEFSQGWVSDFNQNGKNEIYFVTHFSTGRNFLFIIEFNGEFFVTGYVYGNDYDIVGIDWYKKKIIIKDESRSGKWIDDYQWNDTLKEFILLKRKYRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QR3</accession>
    <name>Q73QR3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970994.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681402.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0380"/>
    <dbReference type="EnsemblBacteria" id="AAS10875">
        <property type="protein sequence ID" value="AAS10875"/>
        <property type="gene ID" value="TDE_0380"/>
    </dbReference>
    <dbReference type="GeneID" id="2739473"/>
    <dbReference type="KEGG" id="tde:TDE_0380"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.369"/>
    <dbReference type="HOGENOM" id="CLU_1467603_0_0_12"/>
    <dbReference type="OrthoDB" id="2123831at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004286043" evidence="1">
        <location>
            <begin position="23"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="183" mass="21853" checksum="5481793F27880302" modified="2004-07-05" version="1">MSVYKKITCSIFLILFSISLFAEQNWWEEEDFSYTQDKTKYEQIFSTRNDNKITEAKIIALMKEKMNAYLKNSSHCAYEWMIYDESYKQQNKWELRIMKLSKPNFTGYDIWFYFSNGVFLLRFADDRFLSTVFEMGASAKPINTDTEDNIVNALLDCQLSSRKMWIKHGLKPKGFFPMKFMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QS8</accession>
    <name>Q73QS8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970979.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681373.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0365"/>
    <dbReference type="EnsemblBacteria" id="AAS10860">
        <property type="protein sequence ID" value="AAS10860"/>
        <property type="gene ID" value="TDE_0365"/>
    </dbReference>
    <dbReference type="GeneID" id="2741085"/>
    <dbReference type="KEGG" id="tde:TDE_0365"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.355"/>
    <dbReference type="eggNOG" id="COG1451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065947_1_0_12"/>
    <dbReference type="OMA" id="RLNWRLM"/>
    <dbReference type="OrthoDB" id="1301886at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="232" mass="27644" checksum="FA16F370AC25B1D4" modified="2004-07-05" version="1">MIVIISDISVEICKKNIKNMHLYVKPPYGKVSVSAPYSVKNQTIEMFIRTKLSWIKKQISKFENQARQTKREYISGETFYVWGKRYYLQLEYGNKTSITLLGNKAVFTGSKNRTMESSERFIREWYRSLLKTEIERILPKWKKITGLIPSSWQTKYMTTRWGSCNSTTKKIWLNVQLAKKTPECLEYVILHELIHLEEKNHNDRFIALMDKHMPMWREIKDSLNSQPLDYMK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-06-13" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QW4</accession>
    <name>CAS2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cas2</name>
        <name type="ordered locus">TDE_0329</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970943.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002666293.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="PDB" id="6JHZ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B=1-93"/>
    </dbReference>
    <dbReference type="PDBsum" id="6JHZ"/>
    <dbReference type="AlphaFoldDB" id="Q73QW4"/>
    <dbReference type="SMR" id="Q73QW4"/>
    <dbReference type="STRING" id="243275.TDE_0329"/>
    <dbReference type="DNASU" id="2741545"/>
    <dbReference type="EnsemblBacteria" id="AAS10824">
        <property type="protein sequence ID" value="AAS10824"/>
        <property type="gene ID" value="TDE_0329"/>
    </dbReference>
    <dbReference type="GeneID" id="2741545"/>
    <dbReference type="KEGG" id="tde:TDE_0329"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.318"/>
    <dbReference type="eggNOG" id="COG3512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150500_1_1_12"/>
    <dbReference type="OrthoDB" id="1841250at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0051">Antiviral defense</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000417739" description="CRISPR-associated endoribonuclease Cas2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="2"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="33"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="74"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="2">
        <source>
            <dbReference type="PDB" id="6JHZ"/>
        </source>
    </evidence>
    <sequence length="101" mass="11779" checksum="E3E0BEAF583703C8" modified="2004-07-05" version="1">MRVIVFFDLPVITPENRHNYSVFRKYLIKSGFIMQQKSVYSKLVLNLTNRDSIVKSIEKNKPPEGLVEVLTVTEKQYAKMEIIIGESKTEYLNTDERLVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QY4</accession>
    <name>Q73QY4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970923.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681258.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0309"/>
    <dbReference type="EnsemblBacteria" id="AAS10804">
        <property type="protein sequence ID" value="AAS10804"/>
        <property type="gene ID" value="TDE_0309"/>
    </dbReference>
    <dbReference type="GeneID" id="2741030"/>
    <dbReference type="KEGG" id="tde:TDE_0309"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.298"/>
    <dbReference type="eggNOG" id="ENOG5032C3Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_902962_0_0_12"/>
    <dbReference type="OrthoDB" id="26571at203691"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="316" mass="38237" checksum="EAB4D8B17F859A20" modified="2004-07-05" version="1">MKLKCAVFINLIILLVILTLSISCSKEEKLQPINVIQEGSAKKSDEAIELDLKFYNPFMYEINIRKLKYTNINSNYYVLPETMKKCKQIHIFESWTNEYISYLSDLVMQYDMPCQAYLPENQKTLKSFALFNKNGQVVKYVYKLGCIPTDSYSHDEVYTYYYNDKNFISKDVYKMENTDSEVRQFVNEYEKKRKDKKILYNEKENKYTFDDMELIFNEDGKYKEIKIYYHERSFDKYEFIYENAMIKKFKKYDNDKLEYEIISEYDNSGKIRKYTTSLGGTVEILQYDEYDNWIEEKFFSDGVLFSTTYREIEYWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R03</accession>
    <name>Q73R03_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970904.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10785">
        <property type="protein sequence ID" value="AAS10785"/>
        <property type="gene ID" value="TDE_0290"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3399003_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="31" mass="3787" checksum="F6BC2017ED456187" modified="2004-07-05" version="1">MFKSLIRQDDNKKIVTIMHIFYAKRDYGKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R95</accession>
    <name>Q73R95_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970812.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681091.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0196"/>
    <dbReference type="EnsemblBacteria" id="AAS10693">
        <property type="protein sequence ID" value="AAS10693"/>
        <property type="gene ID" value="TDE_0196"/>
    </dbReference>
    <dbReference type="GeneID" id="2741615"/>
    <dbReference type="KEGG" id="tde:TDE_0196"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.192"/>
    <dbReference type="eggNOG" id="ENOG5030V2I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179376_3_2_12"/>
    <dbReference type="OMA" id="AMKVTHI"/>
    <dbReference type="OrthoDB" id="2064132at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019239">
        <property type="entry name" value="VapB_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09957">
        <property type="entry name" value="VapB_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="64" mass="7444" checksum="880D57F5B4525815" modified="2004-07-05" version="1">MRTTIVLNESKIQQAFALTKIKTKTELIEVAIDNLIKKYQIQDLKSYFGKCNLEIDLDTLRNRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RA1</accession>
    <name>Q73RA1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_0190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970806.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681080.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0190"/>
    <dbReference type="EnsemblBacteria" id="AAS10687">
        <property type="protein sequence ID" value="AAS10687"/>
        <property type="gene ID" value="TDE_0190"/>
    </dbReference>
    <dbReference type="GeneID" id="2741037"/>
    <dbReference type="KEGG" id="tde:TDE_0190"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.186"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032828_0_1_12"/>
    <dbReference type="OMA" id="MGVCVKL"/>
    <dbReference type="OrthoDB" id="1420919at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004285037" evidence="2">
        <location>
            <begin position="28"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="8"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="151"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS10687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="295" mass="32459" checksum="957C6B7A40B77159" modified="2004-07-05" version="1">MKLTSKQKGIMFLILSALCFASMNLSAKLAGSLPSMQKAFFRNLIAAAVSFTVLINSKEKFHLNKKNLPFFFMRAIFGTMGIVGNFYAIEHMLLADASILAKLAPFFAILFSFLFLKEKIKLYQILAVITAFSASLLIIKPAFADTGHVIAALVGACGGMMAGAAYTCVRCLSLKGEKGPLIVFFFSFFSILMLFPLFIIFYHPMSLYQIIMLLIAGLFGTGGQFCVTAAYAHAPAGSISVYDYTQIVFSAIFGFAFLGELPDRWSLLGFAIIFAVALFMFLHHEDKTEVHVDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RB4</accession>
    <name>Q73RB4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970793.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681060.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0177"/>
    <dbReference type="EnsemblBacteria" id="AAS10674">
        <property type="protein sequence ID" value="AAS10674"/>
        <property type="gene ID" value="TDE_0177"/>
    </dbReference>
    <dbReference type="GeneID" id="2739350"/>
    <dbReference type="KEGG" id="tde:TDE_0177"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.174"/>
    <dbReference type="eggNOG" id="COG3819">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010374">
        <property type="entry name" value="DUF969"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06149">
        <property type="entry name" value="DUF969"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="37"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="224" mass="24298" checksum="DBA0EF5873CBF881" modified="2004-07-05" version="1">MNYLVLIGVAIIIAGFILKLDVVAVVLISGLVTGLIAKMGFVEVLNAIGTGFVNNRYMSLFFISFPVIAIMERYGLKERAADFIKKIKGASAGMVIWLYILIRTIACAFSIRLGGHVQFIRPLILPMAEGAAQKHVKLTEDDIEKIKGLAGASENYGNFFGQNIFPVASGVLLITGTLKEQGLDITNTDVAKYSILAGVAMVLIALVQCWLFEKSLRKGEKADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="5">Methyl-accepting chemotaxis domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ordered locus">TDE_0169</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS10666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
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    <dbReference type="RefSeq" id="WP_002681051.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0169"/>
    <dbReference type="EnsemblBacteria" id="AAS10666">
        <property type="protein sequence ID" value="AAS10666"/>
        <property type="gene ID" value="TDE_0169"/>
    </dbReference>
    <dbReference type="GeneID" id="2739521"/>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.166"/>
    <dbReference type="eggNOG" id="COG0840">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000008212">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="MCPsignal_dom"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0807">Transducer</keyword>
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            <end position="196"/>
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        <location>
            <begin position="345"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="325"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="552" mass="60877" checksum="9D23AE3C64787CF0" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RI8</accession>
    <name>Q73RI8_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_S9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AAS10598">
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    </dbReference>
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    <dbReference type="PATRIC" id="fig|243275.7.peg.100"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="AB_hydrolase"/>
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    </dbReference>
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        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
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        <location>
            <begin position="445"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="656" mass="75405" checksum="2056559CCB0AD8C4" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RI9</accession>
    <name>Q73RI9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenine-specific DNA modification methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_0099</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970716.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680948.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0099"/>
    <dbReference type="REBASE" id="6391">
        <property type="entry name" value="M.TdeIV"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10597">
        <property type="protein sequence ID" value="AAS10597"/>
        <property type="gene ID" value="TDE_0099"/>
    </dbReference>
    <dbReference type="GeneID" id="2741714"/>
    <dbReference type="KEGG" id="tde:TDE_0099"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.99"/>
    <dbReference type="eggNOG" id="COG2189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020164_2_3_12"/>
    <dbReference type="OMA" id="SLWITID"/>
    <dbReference type="OrthoDB" id="1487464at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015855">
        <property type="entry name" value="TypeIII_Mtase_mKpnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="65"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS10597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="428" mass="49717" checksum="D4827BB93695D3F3" modified="2004-07-05" version="1">MGVFTWEGKDKALSELNLLLKNQSKFSFTENKVKSFNSEDAKNLYIESDNLYALLFLQKDYKDKIKIIYIDPPYNTGKKFTYADNFQTKTEWMNYLYVRLSLAKNLLTDDGLIFISIDDKTCPYLRIILDEIFGTKNFISTLVWNNSTGGGLRKKHINTSHEYIILYAKDKTKVKPMTAPMPEKAKKMYKYKDADGRFFRYQQFAWKNKTDAKRQKYPIKTPDGNFIIPKAGYIYRFVEKSFFNLLEKNLIEFKKSDKSVFTDIKGRPTKWTIYVKTYLEKKEETVPKSLLPAEYVKTNIQSVYEQKVLFGAKIFDYAKPVSLLKYLFKLVPNSDDAVVLDFFSGSATTAHAVMELNAELNENRKFILVQRGEPCSEDSPALKAGFKTIAELGRERIIRASALIQKRFTQKTFGFKYLELSGEQGFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RM9</accession>
    <name>Q73RM9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970676.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0059"/>
    <dbReference type="EnsemblBacteria" id="AAS10557">
        <property type="protein sequence ID" value="AAS10557"/>
        <property type="gene ID" value="TDE_0059"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0059"/>
    <dbReference type="HOGENOM" id="CLU_3367945_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="35" mass="4090" checksum="A854A7C4E236D709" modified="2004-07-05" version="1">MGTDYKRVIVPVFLLVIGIRCRQQENKPAACKKWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RP5</accession>
    <name>Q73RP5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970657.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680894.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0040"/>
    <dbReference type="EnsemblBacteria" id="AAS10538">
        <property type="protein sequence ID" value="AAS10538"/>
        <property type="gene ID" value="TDE_0040"/>
    </dbReference>
    <dbReference type="GeneID" id="2741655"/>
    <dbReference type="KEGG" id="tde:TDE_0040"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.42"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_10_12"/>
    <dbReference type="OMA" id="HAWSNLF"/>
    <dbReference type="OrthoDB" id="326708at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="39"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="461"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="550" mass="62576" checksum="C8B8062A59326277" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-04-13" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>P60794</accession>
    <name>LEPA_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 4</fullName>
            <shortName evidence="1">EF-4</shortName>
            <ecNumber evidence="1">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lepA</name>
        <name type="ordered locus">TDE_1893</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972496.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957093.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P60794"/>
    <dbReference type="SMR" id="P60794"/>
    <dbReference type="STRING" id="243275.TDE_1893"/>
    <dbReference type="EnsemblBacteria" id="AAS12407">
        <property type="protein sequence ID" value="AAS12407"/>
        <property type="gene ID" value="TDE_1893"/>
    </dbReference>
    <dbReference type="GeneID" id="2739122"/>
    <dbReference type="KEGG" id="tde:TDE_1893"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1792"/>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_12"/>
    <dbReference type="OMA" id="MVQIAIQ"/>
    <dbReference type="OrthoDB" id="182107at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176365" description="Elongation factor 4">
        <location>
            <begin position="1"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="5"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <sequence length="601" mass="67231" checksum="7A31762B18BA6C36" modified="2004-04-13" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-06-07" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>P61912</accession>
    <name>DUT_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="1">dUTPase</shortName>
            <ecNumber evidence="1">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dut</name>
        <name type="ordered locus">TDE_1042</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971650.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682351.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61912"/>
    <dbReference type="SMR" id="P61912"/>
    <dbReference type="STRING" id="243275.TDE_1042"/>
    <dbReference type="EnsemblBacteria" id="AAS11531">
        <property type="protein sequence ID" value="AAS11531"/>
        <property type="gene ID" value="TDE_1042"/>
    </dbReference>
    <dbReference type="GeneID" id="2741316"/>
    <dbReference type="KEGG" id="tde:TDE_1042"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1002"/>
    <dbReference type="eggNOG" id="COG0756">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068508_1_2_12"/>
    <dbReference type="OMA" id="YAAFVHP"/>
    <dbReference type="OrthoDB" id="1669228at2"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000182912" description="Deoxyuridine 5'-triphosphate nucleotidohydrolase">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <sequence length="144" mass="15402" checksum="A3D741BD3B6E85BA" modified="2004-06-07" version="1">MEVFTKLKEGALLPEYKTSGSAGADLRALIEEPIILKPMQRCLIPTGLSVELPKGIELQVRPRSGLALKHGITVLNTPGTVDSDYRGELAVLLINLGNEDFKIENGDRIAQAVIAQAIQADFLQKDELSNTERGAGGYGSTGIA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-06-21" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>P62042</accession>
    <name>Y1487_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable transcriptional regulatory protein TDE_1487</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_1487</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972093.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668967.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P62042"/>
    <dbReference type="SMR" id="P62042"/>
    <dbReference type="STRING" id="243275.TDE_1487"/>
    <dbReference type="EnsemblBacteria" id="AAS12004">
        <property type="protein sequence ID" value="AAS12004"/>
        <property type="gene ID" value="TDE_1487"/>
    </dbReference>
    <dbReference type="GeneID" id="2739888"/>
    <dbReference type="KEGG" id="tde:TDE_1487"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1426"/>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_2_2_12"/>
    <dbReference type="OMA" id="ETIMYEG"/>
    <dbReference type="OrthoDB" id="1304328at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000175921" description="Probable transcriptional regulatory protein TDE_1487">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <sequence length="247" mass="26295" checksum="EC1A0708A719251E" modified="2004-06-21" version="1">MSGHSKWATIKHAKGAADAKRGQLFTKFIKEISIAAKMGGGDPATNPRLRTAVLKARAANMPKDNIERAIKKGTGELGAVNYEELLYEGYGPGGVAVLVEVLTDNKNRTAASVRNIFTKSGGNLGATGSVAYMFNRKGVIEYDAEVVSEEAIMEAALEAGAEDIATEDGVITVTTDPNDFASVLEALQEKGFESVSAAVSMVPDTYVALDADTTQKALKMIDKLEEDDDVQTVSSNIEIPEGFEMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J06</accession>
    <name>Q73J06_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973369.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680834.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2771"/>
    <dbReference type="EnsemblBacteria" id="AAS13288">
        <property type="protein sequence ID" value="AAS13288"/>
        <property type="gene ID" value="TDE_2771"/>
    </dbReference>
    <dbReference type="GeneID" id="2740738"/>
    <dbReference type="KEGG" id="tde:TDE_2771"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2616"/>
    <dbReference type="eggNOG" id="COG5464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_966257_0_0_12"/>
    <dbReference type="OrthoDB" id="2227873at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="283" mass="33161" checksum="364CF6A649DDBE4F" modified="2004-07-05" version="1">MNDEQTILNPKTDWVFKLMFSKGEEGNKALISFLNAFLEDSYGKINKAEIINTELIRDRPSGETYRLDFLIKTDNGLIIDLEMQQFWKTNYHRRSQMYLMRLASRFLKTEPKEDDFLYAISLSVFGCDVPKNAELVRMSESSIIQYLYVELNELIVYTMKKRLEEYSLKDFWIRFLANYEEDKKSGMLEELCKLEEGIKMAEATLFRVTDEERRMAIELSDEKYRMYVEDERSEARREGLAEGLAEGSHQKALETARNLLDMGLSPKNIARATGLDIKEIEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J36</accession>
    <name>Q73J36_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type I restriction-modification system, S subunit, truncation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_2740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-I restriction system S methylase family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973338.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680800.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2740"/>
    <dbReference type="REBASE" id="6396">
        <property type="entry name" value="S.TdeORF2746AP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS13257">
        <property type="protein sequence ID" value="AAS13257"/>
        <property type="gene ID" value="TDE_2740"/>
    </dbReference>
    <dbReference type="GeneID" id="2740959"/>
    <dbReference type="KEGG" id="tde:TDE_2740"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2586"/>
    <dbReference type="eggNOG" id="COG0732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021095_3_3_12"/>
    <dbReference type="OrthoDB" id="827072at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000055">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044946">
        <property type="entry name" value="Restrct_endonuc_typeI_TRD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01420">
        <property type="entry name" value="Methylase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0680">Restriction system</keyword>
    <feature type="domain" description="Methylase_S" evidence="4">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS13257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="162" mass="18489" checksum="83CE915F9141D6EE" modified="2004-07-05" version="1">MWCRLGEICSITMGQSPESSFISNNSDGMEFHQGKIHFTEKYIQKANNYTFNITKIAPKNAILLCVRAPVGVVNITEREICIGRGLCSVYPKYRIQSEFWFYWLQCQKDTFEQKSTGTTFQAISIELIKNILIPLPPSSEQKRIVAKIEELFAQLDSITAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q73J88</accession>
    <name>Q73J88_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973286.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2688"/>
    <dbReference type="EnsemblBacteria" id="AAS13205">
        <property type="protein sequence ID" value="AAS13205"/>
        <property type="gene ID" value="TDE_2688"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2688"/>
    <dbReference type="HOGENOM" id="CLU_3278176_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS13205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="41" mass="5164" checksum="B5D351D659EDC72E" modified="2004-07-05" version="1">MANNLNCIDYKNLFLTYYFFQIFSINIMGRRKIKKSRRKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JI1</accession>
    <name>Q73JI1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2594</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973192.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002667248.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2594"/>
    <dbReference type="EnsemblBacteria" id="AAS13111">
        <property type="protein sequence ID" value="AAS13111"/>
        <property type="gene ID" value="TDE_2594"/>
    </dbReference>
    <dbReference type="GeneID" id="2741298"/>
    <dbReference type="KEGG" id="tde:TDE_2594"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2452"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064306_0_0_12"/>
    <dbReference type="OMA" id="IQIWLKM"/>
    <dbReference type="OrthoDB" id="1290611at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS13111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="366" mass="41373" checksum="1EAC69055101463A" modified="2004-07-05" version="1">MAISVVDQGKKLLSKKKYNDVISLLEPHVVEYRDSFAFHFYLGLASFHVGDIQGAMDYFLRARQIKPTDSDLLSTYAAMALRRSLTTEAVEYYLQALEHNPNCKLAKKGLDIIRKNNSPEKLGNFVQSGKIKTLFPRPGHEEKKGRSIAVALVLGISIISFVFIVPYITKTRNFSDSGRANLEEFKLDSNERKYAVDMEGSYIYVLTQSQILKAYSDAQTYFNAHRDNAAQVEINRLLSSNASFSIKQKSRLLMDYFEEPGFDNIQDIYSYAQVKQEPLLYLDCWVVWKGMPANIQTGTYSTAFNLLVGYDTKQILEGVVPVFCDFVSKIDPDRPVNVLGQIIIKDGTVCLKGKGIHQTQKPAEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q73JZ6</accession>
    <name>Q73JZ6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS13060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_973141.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2543"/>
    <dbReference type="EnsemblBacteria" id="AAS13060">
        <property type="protein sequence ID" value="AAS13060"/>
        <property type="gene ID" value="TDE_2543"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2543"/>
    <dbReference type="HOGENOM" id="CLU_2848528_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS13060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="65" mass="7541" checksum="2CAC28E23EBC04A5" modified="2004-07-05" version="1">MSYTVSIVVEPCGLKRRRSLSTVCTGTESRQLYLLRYEEETYEKKCYFTVCGSTAYRCAYTANFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K55</accession>
    <name>Q73K55_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_2367</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972966.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680289.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2367"/>
    <dbReference type="EnsemblBacteria" id="AAS12885">
        <property type="protein sequence ID" value="AAS12885"/>
        <property type="gene ID" value="TDE_2367"/>
    </dbReference>
    <dbReference type="GeneID" id="2739976"/>
    <dbReference type="KEGG" id="tde:TDE_2367"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2235"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_2_12"/>
    <dbReference type="OMA" id="NIVSECE"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="FCD" evidence="5">
        <location>
            <begin position="85"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="214" mass="25203" checksum="012679566E2104AA" modified="2004-07-05" version="1">MTTDKLITKKKSLKQDAYIKIYDLVTDNTIKPGDIINLSDLEKYLKISRAPIRDALIELCNENVFKSIPRYGYELITLRQEDLVEMLNYRLVLECGFLEKNWKEVANSDHAILNKLLEHTREFSNTNAVSEWQNNSVFHIGLFKLHNNSHALLSLEHTMKKMTRFFIQNYWEKWEEITKKTFSSHHENIIYAIKKNDKARALKHLSSDIGGFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73K73</accession>
    <name>Q73K73_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972948.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002674261.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2349"/>
    <dbReference type="EnsemblBacteria" id="AAS12867">
        <property type="protein sequence ID" value="AAS12867"/>
        <property type="gene ID" value="TDE_2349"/>
    </dbReference>
    <dbReference type="GeneID" id="2739958"/>
    <dbReference type="KEGG" id="tde:TDE_2349"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2217"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081869_0_0_12"/>
    <dbReference type="OMA" id="VEESYLQ"/>
    <dbReference type="OrthoDB" id="1785957at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284553" evidence="1">
        <location>
            <begin position="23"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="234" mass="26234" checksum="3EFAE00D3DB2AF9A" modified="2004-07-05" version="1">MRRKSLVFIMMILFLGSAMVFAQDQSSDSMMTVEEAYLNSMEGIILREMVLSEGRDAKFVALQVIEEAIEGGRVTPELQEALDSLATVGLTSVVRENGRLANNYPDVRREACRLLGKVKNEQAKKSLMTVMYTDNEPVVIMEAVKSLGELGFNNNDEVVDMINFINRKFDIINPTSSLALEVLNAYEKLAPTVKNKRGMTESIMRIANNFNYITPVRNRALEVLKSIMAGQNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KK3</accession>
    <name>Q73KK3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Galactoside ABC transporter, permease protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_2215</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972815.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680065.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2215"/>
    <dbReference type="EnsemblBacteria" id="AAS12734">
        <property type="protein sequence ID" value="AAS12734"/>
        <property type="gene ID" value="TDE_2215"/>
    </dbReference>
    <dbReference type="GeneID" id="2739491"/>
    <dbReference type="KEGG" id="tde:TDE_2215"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2092"/>
    <dbReference type="eggNOG" id="COG4211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_481395_0_0_12"/>
    <dbReference type="OMA" id="MFYALGV"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030158">
        <property type="entry name" value="MglC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32196:SF18">
        <property type="entry name" value="PTHR32196:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="564" mass="62006" checksum="8A0CD1C540D229BD" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KP8</accession>
    <name>Q73KP8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972770.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002680010.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2169"/>
    <dbReference type="EnsemblBacteria" id="AAS12689">
        <property type="protein sequence ID" value="AAS12689"/>
        <property type="gene ID" value="TDE_2169"/>
    </dbReference>
    <dbReference type="GeneID" id="2739155"/>
    <dbReference type="KEGG" id="tde:TDE_2169"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2049"/>
    <dbReference type="eggNOG" id="ENOG5031E6E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160076_0_0_12"/>
    <dbReference type="OrthoDB" id="1698951at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017259">
        <property type="entry name" value="UCP037672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12650">
        <property type="entry name" value="DUF3784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="130" mass="14861" checksum="07AEB6604D6BC9BE" modified="2004-07-05" version="1">MITFYIIAAVLAVFGILIHKFKFYFLIAGYNMMSKEEKEEYNASSIGKHVGFYLYFISVLSLAVGLFFQFFQISKQTEKLVIAVYVIFTMIAVSILLVKENKKRLNEVIPFIVFINIVILIILAVVIFAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KR3</accession>
    <name>RL20_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplT</name>
        <name type="ordered locus">TDE_2154</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972755.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668132.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73KR3"/>
    <dbReference type="SMR" id="Q73KR3"/>
    <dbReference type="STRING" id="243275.TDE_2154"/>
    <dbReference type="EnsemblBacteria" id="AAS12674">
        <property type="protein sequence ID" value="AAS12674"/>
        <property type="gene ID" value="TDE_2154"/>
    </dbReference>
    <dbReference type="GeneID" id="2739140"/>
    <dbReference type="KEGG" id="tde:TDE_2154"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.2035"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123265_0_1_12"/>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="OrthoDB" id="1932144at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000177252" description="50S ribosomal protein L20">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <sequence length="119" mass="13309" checksum="827A92C01E9FCFF9" modified="2004-07-05" version="1">MSRSTSSDRRITRRKAILKQAKGFRGRRGTNFKAARDAVRKALLHSYVGRKDKKSDMRQIWITRINAAVRAEGITYSRFIAGMNKAGIQLNRKALSNMAIEDPTAFKAVVEASKKALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KV7</accession>
    <name>Q73KV7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Orotidine-5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrF</name>
        <name evidence="6" type="ordered locus">TDE_2110</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972711.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957153.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2110"/>
    <dbReference type="EnsemblBacteria" id="AAS12630">
        <property type="protein sequence ID" value="AAS12630"/>
        <property type="gene ID" value="TDE_2110"/>
    </dbReference>
    <dbReference type="GeneID" id="2740349"/>
    <dbReference type="KEGG" id="tde:TDE_2110"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1993"/>
    <dbReference type="eggNOG" id="COG0284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060704_1_0_12"/>
    <dbReference type="OMA" id="QSAFFER"/>
    <dbReference type="OrthoDB" id="1181405at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="5">
        <location>
            <begin position="17"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS12630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="300" mass="32796" checksum="C309332C63264C47" modified="2004-07-05" version="1">MNYIDLLKTSAKKTNNCACMGLDPIFEAVPNKTGMVKDNLVSFFKELFNKMQEKNLIPAAFKPNIGYYSALDKPREKDFSGSESLAEILSLIEKHFPGIPVILDSKRGDIARSSLNYAIEAFDGWKADAVTVSPYMGSDSILPFISEKYLDKGAYILNRTSNPGAKDFQNLKTDSEGKNNSELYIEVAKKIAFYAKEFPGTGAVVGATGMEELKIISGIYAQAGEVPMLIPGVGSQGGDAKTVMEVLKNSGCNLALIRINSSSALTHPWKKAPVPENYLELCINNIEKLLNETAINNISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KX1</accession>
    <name>Q73KX1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_2096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972697.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679900.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2096"/>
    <dbReference type="EnsemblBacteria" id="AAS12616">
        <property type="protein sequence ID" value="AAS12616"/>
        <property type="gene ID" value="TDE_2096"/>
    </dbReference>
    <dbReference type="GeneID" id="2740335"/>
    <dbReference type="KEGG" id="tde:TDE_2096"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1979"/>
    <dbReference type="eggNOG" id="COG3876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033227_1_0_12"/>
    <dbReference type="OMA" id="YIWTLYD"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033922">
        <property type="term" value="F:peptidoglycan beta-N-acetylmuramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008302">
        <property type="entry name" value="NamZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42915">
        <property type="entry name" value="PTHR42915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07075">
        <property type="entry name" value="DUF1343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016719">
        <property type="entry name" value="UCP016719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284568" evidence="1">
        <location>
            <begin position="22"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="403" mass="45762" checksum="C6A48339165BE1F5" modified="2004-07-05" version="1">MKKMFFLFCFFSLAIISFANGKPDESDFKTGIERADEFFNLFKGKRIGLITNQTGIDSSGRSSIEILYEKTNLKALFSPEHGIRGNAREGAGISNTVDKKTGLTVYSLYGKTKRPTKEMLQQIDVLCFDIQDVGARFYTYIYTMAYAMEACARDGKTFVVFDRPNPINGINVEGNILEEEFKSFTGYFPIVQRHGMTVGELALMFNKEFKIGCNLKIVPMQGWKREDYFEDLNLMWVPPSPNISTADTALVYSGFCIFEGVNISVGRGTTMPFKYIGAPYIDAEALAEALNALKLEGVFFKPAYFTPALSVYKEELCEGVQIIVRDKNKFLPVKSAIAVLYTIREMYPNNFKINNYPAELCGLNLLTGTNKLSSKSLSLDDYFKFIEKDEKKFLKMREKYLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q73KX3</accession>
    <name>Q73KX3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_2094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972695.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957145.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS12614">
        <property type="protein sequence ID" value="AAS12614"/>
        <property type="gene ID" value="TDE_2094"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_2094"/>
    <dbReference type="HOGENOM" id="CLU_2588671_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="80" mass="9216" checksum="B6F760BDEC1861F6" modified="2004-07-05" version="1">MTILNLLKKCTKTFSFGYCIIKFKNRKEEKFLLAHQGIIVYNEFGGLINSSAGIQPHCLSAEFAFRQTSHYCMRFCKQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L05</accession>
    <name>Q73L05_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_2061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972663.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010957139.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2061"/>
    <dbReference type="EnsemblBacteria" id="AAS12574">
        <property type="protein sequence ID" value="AAS12574"/>
        <property type="gene ID" value="TDE_2061"/>
    </dbReference>
    <dbReference type="GeneID" id="2741188"/>
    <dbReference type="KEGG" id="tde:TDE_2061"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1945"/>
    <dbReference type="eggNOG" id="COG5266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058596_0_0_12"/>
    <dbReference type="OrthoDB" id="1382281at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019613">
        <property type="entry name" value="DUF4198"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10670">
        <property type="entry name" value="DUF4198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS12574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="337" mass="37529" checksum="BA769BBB5E177AAE" modified="2004-07-05" version="1">MKKLFFSVLLCWTALGLFAHFQIIYTPASIIEASNNKVDFIISFTHPFDSGLTMDIGKNEAGEIKGLKEFYSVHKENKTDLMPFLKKGEFESAENKAFAYTFEFDKEAGFKGGGDWVLVAVPHPYFEAADDGYIQQITKVFINKAGLSTDWQSRVAEGYPEILPLVKPYDIWEGGVIRALVLDSDGKPVPYAQVEFENMNYDVDMTNKKFTGEPKLQKAGAGMIMADNTGVFEFIPPCPGYWGFAALRVGKEKEFGGKELSQDAVIWFEVSKIEDAAEQADSTKQADISSSDGEPSERAKPKEGFSPAALIIVILLFVVMFAWPPIFKKISDKAENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L11</accession>
    <name>Q73L11_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hemin-binding protein B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hbpB</name>
        <name evidence="4" type="ordered locus">TDE_2055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972657.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679845.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2055"/>
    <dbReference type="EnsemblBacteria" id="AAS12568">
        <property type="protein sequence ID" value="AAS12568"/>
        <property type="gene ID" value="TDE_2055"/>
    </dbReference>
    <dbReference type="GeneID" id="2740649"/>
    <dbReference type="KEGG" id="tde:TDE_2055"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1940"/>
    <dbReference type="eggNOG" id="COG3443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694323_0_0_12"/>
    <dbReference type="OrthoDB" id="1046330at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015304">
        <property type="entry name" value="ZinT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09223">
        <property type="entry name" value="ZinT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284572" evidence="2">
        <location>
            <begin position="26"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="ZinT" evidence="3">
        <location>
            <begin position="40"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS12568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="403" mass="44807" checksum="E4A22A2FE59CF91A" modified="2004-07-05" version="1">MSTKNFGAKLVLVLMVLAVTFTACKSMPNTIGGMKIEPGKELAAWKGEWVSLDSAKNDPSLNPVYKEAAAKMENYTVEGFKLAVEGMYRTSFSKIKFDGTNTVVFTVKDADGKEKEISSEYVYKGKVPVIGYDGYYWETFEAVKNVRGLTMAKYIICFPPHQDSEGGLLHWHVRTGGSGIDALVKADTMWWPTYVSASMTKEELVKNFKDTIGAVAGMFPKSPFEPYAKEGKWMNSSLIYDNTSAEVNAAYNKIIKEFAGKNPKGGDFTKAEIIAEMKKVYGTTDLYTHIEFVTEDGKNEFVVYKDGKEIHRAAYKRTAENASKPGLLAVVTDKKDAGMFKTISLTSAGGNPLHFHFWYGMNDADFSKIKEKPTCIPANTPNKMIAERVEKSCRKILKGIVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q73L57</accession>
    <name>Q73L57_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">TDE_2008</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972611.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679767.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_2008"/>
    <dbReference type="EnsemblBacteria" id="AAS12522">
        <property type="protein sequence ID" value="AAS12522"/>
        <property type="gene ID" value="TDE_2008"/>
    </dbReference>
    <dbReference type="GeneID" id="2740355"/>
    <dbReference type="KEGG" id="tde:TDE_2008"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1896"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_12"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="30"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="338"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="375"/>
            <end position="382"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAS12522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="585" mass="64735" checksum="83918A7E23291F9D" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LA6</accession>
    <name>Q73LA6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HicB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679681.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1959"/>
    <dbReference type="EnsemblBacteria" id="AAS12473">
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        <property type="gene ID" value="TDE_1959"/>
    </dbReference>
    <dbReference type="GeneID" id="2741522"/>
    <dbReference type="KEGG" id="tde:TDE_1959"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1851"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114047_0_2_12"/>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031807">
        <property type="entry name" value="HicB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15919">
        <property type="entry name" value="HicB_lk_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HicB-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="130" mass="14600" checksum="AC60122BCAC14A4B" modified="2004-07-05" version="1">MKYTYPVIFENDDGKIGVRVPDISGCFTFGDTVTEAIEMAEDAIAMMLAHYEDNNQAIPKASNISDVKIKDGFVNYVIADTDKWRRQFSEKSVKKTVTIPAWLNYKAETANLNFSQELQNALKAKLQVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LN6</accession>
    <name>Q73LN6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
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            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AAS12341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="WP_002681203.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1826"/>
    <dbReference type="EnsemblBacteria" id="AAS12341">
        <property type="protein sequence ID" value="AAS12341"/>
        <property type="gene ID" value="TDE_1826"/>
    </dbReference>
    <dbReference type="GeneID" id="2740488"/>
    <dbReference type="KEGG" id="tde:TDE_1826"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1732"/>
    <dbReference type="HOGENOM" id="CLU_677817_0_0_12"/>
    <dbReference type="OrthoDB" id="1574236at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="210"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="406" mass="45317" checksum="C8AE379D2DBA3A67" modified="2004-07-05" version="1">MKLKYQIILLYCLITLLLFQMVSCKRQQGKQVIKYETKDSFKKVAVELKPVTSNVYEELKRIHTVYPKRAMKGNGLVGVLGGVNLIAHQKGSYDVLLPIPQLVDKQVPIFYSLSVKPESALSSSRLQVREDGNAFLSLVFNADQNTELTIDWSAVVLITPMAIKENDIDPELFTVASPCVQSDSKQITDLATELCTTNEDDELKQYCLNIRNFIANMENVAPPMSLDALGILKSGMNYICTSNANLAAAFMRAQKIPCRMIATIPTNSYRLEMHRIVEYYDGGVWTAFDPSSWSESPLTNTWQNIIMAKSSISDEIASMEPRLCSMLGVPFGQEVEIMKPGLTLHGQDFFWTVAFPLAEFDVTDTIAKLTVACWQEFLQTGIISSKQIDAALATDLDSYSEKISGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LU2</accession>
    <name>Q73LU2_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972374.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1770"/>
    <dbReference type="EnsemblBacteria" id="AAS12285">
        <property type="protein sequence ID" value="AAS12285"/>
        <property type="gene ID" value="TDE_1770"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1770"/>
    <dbReference type="HOGENOM" id="CLU_3123849_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="50" mass="5831" checksum="F8F2A091C9F8CA44" modified="2004-07-05" version="1">MSEACAVANNFEFRENKLNNKKIYIFIFLFINSPLKYNSTSQRGIHVTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q73LU6</accession>
    <name>Q73LU6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1766</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972370.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679517.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1766"/>
    <dbReference type="EnsemblBacteria" id="AAS12281">
        <property type="protein sequence ID" value="AAS12281"/>
        <property type="gene ID" value="TDE_1766"/>
    </dbReference>
    <dbReference type="GeneID" id="2740611"/>
    <dbReference type="KEGG" id="tde:TDE_1766"/>
    <dbReference type="eggNOG" id="ENOG5031XMU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128155_1_0_12"/>
    <dbReference type="OrthoDB" id="1719670at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS12281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="152" mass="17966" checksum="60C9B3C8DB244075" modified="2004-07-05" version="1">MKTKVVYVKSTFPSDIDSVFKLLTDVKTLQYIASPYALFKLIGDDKELVWSEGRTFSFLFKMFSFIPYGTHTIKVINFNKDEIYTNESNTHVPIWNHRIKLIDNGNGTTDYSDEVEIGAGWKTFIVWLWANCFYKHRQRKWLKLIKIRKVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q73M42</accession>
    <name>Q73M42_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_1668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972273.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002679363.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1668"/>
    <dbReference type="EnsemblBacteria" id="AAS12184">
        <property type="protein sequence ID" value="AAS12184"/>
        <property type="gene ID" value="TDE_1668"/>
    </dbReference>
    <dbReference type="GeneID" id="2739009"/>
    <dbReference type="KEGG" id="tde:TDE_1668"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1594"/>
    <dbReference type="eggNOG" id="COG0833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_21_0_12"/>
    <dbReference type="OMA" id="KGIANSF"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS12184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="458" mass="50259" checksum="90B080E353617734" modified="2004-07-05" version="1">MEAKKEKRNLNLFNIFSLGFGGAVGSGIFVLTGLGIAATGKSIVVSIMAGCIFMLLAYFYNVLLSSMFMFEGGDYSQKALVFNPFFTGINGYITFINGFSVAMYSLAMVNYAGIVFPQILPYTKLIAIIIITLFFAATIRGSKFVSTINNIMTVVLILAIIFYIVFGVPKVKPGYFTDPNFFTDGFKGIIAGIAIMGWACQGTTMGPVSVSAVTIKPKKNIPYGIFLVTIAIAIVYGLMGYVSAGVLPISEVAGQNLSLVAAEIFPRSIFILFIMGGAVFAIATSMITGIIMVRYPILKVAQAGWLPKFFTQTTQTGYPWAVYGIYYILSILPVLLGLKLDAIVSLVMIPAMLTNLYTNIKCIKVIRDYPEQWKKSVLHMPRILMDIICILSALCAAIVCYNLFMMLSTKEKLLMIGIMVIISILSIYNLKSKHVKIEELEANKRQIIEDALLAETEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-29" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MC2</accession>
    <name>SYDND_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="1">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="1">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="1">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aspS</name>
        <name type="ordered locus">TDE_1587</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972193.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73MC2"/>
    <dbReference type="SMR" id="Q73MC2"/>
    <dbReference type="STRING" id="243275.TDE_1587"/>
    <dbReference type="EnsemblBacteria" id="AAS12104">
        <property type="protein sequence ID" value="AAS12104"/>
        <property type="gene ID" value="TDE_1587"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1587"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1517"/>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_12"/>
    <dbReference type="OMA" id="YQLDVEM"/>
    <dbReference type="OrthoDB" id="226836at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000110973" description="Aspartate--tRNA(Asp/Asn) ligase">
        <location>
            <begin position="1"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="1">
        <location>
            <begin position="202"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="539"/>
            <end position="542"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <sequence length="590" mass="66578" checksum="44937B0477EF0451" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MG7</accession>
    <name>Q73MG7_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS12058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972147.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669065.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1541"/>
    <dbReference type="EnsemblBacteria" id="AAS12058">
        <property type="protein sequence ID" value="AAS12058"/>
        <property type="gene ID" value="TDE_1541"/>
    </dbReference>
    <dbReference type="GeneID" id="2740903"/>
    <dbReference type="KEGG" id="tde:TDE_1541"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1478"/>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_1_0_12"/>
    <dbReference type="OMA" id="NDQMLHP"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="61"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS12058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="320" mass="36760" checksum="78ABAD8636039B14" modified="2004-07-05" version="1">MLVKFWGVRGSLPAPLTPAQVQSKIAAVVQRITLKDIESQDSRERFLASLPKWLFGTIGSNTACVEVETDDGGHLIFDAGTGIRELGIDLMKRPDYGKNTTYHLFFSHFHWDHIQGLPFFNPAYDPRNKIIVYSTRKKAKEFLEDQMKYPYFPISMLGEDGFGASFEFKYIEPDQKYVEIGDTKIGWHRVRHPGGCTAYSVIEKGKKIIYSTDTELRPRDFERNEQNAEFYTDAEMLIIDAQYTLTDSILKEGWGHSTFSVAIDFAAGWNIKSIALFHHEPTYHDKKVFSLKQTADWYRDCSRAPDIKIFIAQEGRSFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MP3</accession>
    <name>Q73MP3_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Signal peptidase I</fullName>
            <ecNumber evidence="2">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="2"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_972071.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668934.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1465"/>
    <dbReference type="EnsemblBacteria" id="AAS11982">
        <property type="protein sequence ID" value="AAS11982"/>
        <property type="gene ID" value="TDE_1465"/>
    </dbReference>
    <dbReference type="GeneID" id="2741580"/>
    <dbReference type="KEGG" id="tde:TDE_1465"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1406"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_3_0_12"/>
    <dbReference type="OMA" id="RTWGPVP"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="3">
        <location>
            <begin position="25"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="233" mass="27270" checksum="5DA656504E12CBB3" modified="2004-07-05" version="1">MTAKYRNFSYTAKREYQNKVFFIVFLVVFTFLSYILITSYLLKTYRLQTDTMFPEISTGDMVLMTPIYSQASAKRGDLVVIDDTLSQNKSFFKSVVNTLTGFFTFQLLRPFDLQSEDAYSIRRIVGLPGDTLYMENFVLHIKTKDSSHFLTEFELAQQNYDIEVKDLPEHWDSSLPFSGAYPETVLKEGEYFVLCDNRIITDDSRLWGAVEGDKKIYGKIILKYWPFKEFKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MX4</accession>
    <name>Q73MX4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_1382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971988.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002668756.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1382"/>
    <dbReference type="EnsemblBacteria" id="AAS11899">
        <property type="protein sequence ID" value="AAS11899"/>
        <property type="gene ID" value="TDE_1382"/>
    </dbReference>
    <dbReference type="GeneID" id="2741143"/>
    <dbReference type="KEGG" id="tde:TDE_1382"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1326"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_7_3_12"/>
    <dbReference type="OMA" id="YHVEHLR"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018334">
        <property type="entry name" value="ArsR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00846">
        <property type="entry name" value="HTH_ARSR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="117" mass="13050" checksum="BAEDC3FE1AC266E4" modified="2004-07-05" version="1">MIEDDEIGVSNEETVAHARAKMPDEQTMSDLGDFFKNFGDSTRIKIVSALISGELCVADLAEVLEMSASAVSHQLRILRQAKIVKSRRNGKQVYYTIDDNHVGILYSVGLEHIREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q73MZ5</accession>
    <name>Q73MZ5_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971967.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1361"/>
    <dbReference type="EnsemblBacteria" id="AAS11878">
        <property type="protein sequence ID" value="AAS11878"/>
        <property type="gene ID" value="TDE_1361"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_1361"/>
    <dbReference type="HOGENOM" id="CLU_2144755_0_0_12"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="112" mass="12674" checksum="9B6AE524CC51B06D" modified="2004-07-05" version="1">MRKFFYGSIFIILILTLTTCKQFIADIEKDFENWVSTVLIKEIIPDSPKDGQSYLCIPSASDQTVTLKLLNSRRHSLKMPEGPGTYTDIITFESGVKGIDGGVPVQWYRLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NE9</accession>
    <name>Q73NE9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 8" type="primary">ftsZ</name>
        <name evidence="8" type="ordered locus">TDE_1204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971811.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002678695.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1204"/>
    <dbReference type="EnsemblBacteria" id="AAS11722">
        <property type="protein sequence ID" value="AAS11722"/>
        <property type="gene ID" value="TDE_1204"/>
    </dbReference>
    <dbReference type="GeneID" id="2741165"/>
    <dbReference type="KEGG" id="tde:TDE_1204"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1159"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_12"/>
    <dbReference type="OMA" id="GNPSIGQ"/>
    <dbReference type="OrthoDB" id="1009041at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="22"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="7">
        <location>
            <begin position="216"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="30"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAS11722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="427" mass="45925" checksum="77BB564D0E90357F" modified="2004-07-05" version="1">MLYEVMEDKVNNEVVDAGTPAIIKVIGAGGGGSNAVNRMMSSNMRYVDFIVANTDLQALRHSNAPLKLPIGTKITKGLGSGGDPEIGEQAAIEDREIIANAIKDADMLFITAGMGGGTGTGSAPIIAEIAKEQGILTVAVVTKPFAFEGRKRMSLAEEGIKKLRESVDTVITIPNQHLLNMVDPSTPVVEAFKKADDVLRQAVQGISDLIYQHGEINVDLADVKAVMKAQGNAHMGVGIGEGQNRAVDAATNALNNPLLEEARVEGAKNLLVNICGSEKLTMHELSEIMDIINAGADPDVATFFGATIDPSVENKVVVTLIATGFRSNDKFPIDDAASNRKPVRDNAENLVFTDDSFMTSREWTKVNKTTPPTLSGLGLRNRSETSSEKHYEDIYVAERKPSFSSIVPPMESDLETPAYYRNQNALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NJ0</accession>
    <name>Q73NJ0_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ParB-like nuclease domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">TDE_1162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971770.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956908.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1162"/>
    <dbReference type="EnsemblBacteria" id="AAS11651">
        <property type="protein sequence ID" value="AAS11651"/>
        <property type="gene ID" value="TDE_1162"/>
    </dbReference>
    <dbReference type="GeneID" id="2741494"/>
    <dbReference type="KEGG" id="tde:TDE_1162"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1121"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_502409_0_0_12"/>
    <dbReference type="OrthoDB" id="1375763at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAS11651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="542" mass="63550" checksum="70EA3762B01E3F8B" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NJ8</accession>
    <name>Q73NJ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971762.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_010956901.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1154"/>
    <dbReference type="EnsemblBacteria" id="AAS11643">
        <property type="protein sequence ID" value="AAS11643"/>
        <property type="gene ID" value="TDE_1154"/>
    </dbReference>
    <dbReference type="GeneID" id="2741486"/>
    <dbReference type="KEGG" id="tde:TDE_1154"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1113"/>
    <dbReference type="HOGENOM" id="CLU_175514_1_1_12"/>
    <dbReference type="OrthoDB" id="2070400at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="81" mass="9219" checksum="60BCF3004442082A" modified="2004-07-05" version="1">MKNKLTDLNNHLFEQIERLMDDEVMEKNADLEIKKADAVVKVAEAIIKNANLSLQAYKYADEWKTGNAKVPEMLRIGVGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NN6</accession>
    <name>Q73NN6_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971724.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002677634.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1116"/>
    <dbReference type="EnsemblBacteria" id="AAS11605">
        <property type="protein sequence ID" value="AAS11605"/>
        <property type="gene ID" value="TDE_1116"/>
    </dbReference>
    <dbReference type="GeneID" id="2739532"/>
    <dbReference type="KEGG" id="tde:TDE_1116"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1076"/>
    <dbReference type="eggNOG" id="COG4737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110687_1_2_12"/>
    <dbReference type="OMA" id="DEDEYHK"/>
    <dbReference type="OrthoDB" id="2029118at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009387">
        <property type="entry name" value="HigB-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06296">
        <property type="entry name" value="RelE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039032">
        <property type="entry name" value="HigB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="102" mass="11737" checksum="1470D1CDBCDA3C51" modified="2004-07-05" version="1">MRIIETPVFTKQINRLLDEDTYKQFKEYLVCNPLKGKLIKGGGGIRKIRWSKKNTGKSGGIRIIYFIKTETKIYLLFAYSKSDAESITKKQINMLASFIKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NQ8</accession>
    <name>Q73NQ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">TDE_1094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971702.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682403.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1094"/>
    <dbReference type="CAZy" id="GH57">
        <property type="family name" value="Glycoside Hydrolase Family 57"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11583">
        <property type="protein sequence ID" value="AAS11583"/>
        <property type="gene ID" value="TDE_1094"/>
    </dbReference>
    <dbReference type="GeneID" id="2740224"/>
    <dbReference type="KEGG" id="tde:TDE_1094"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1053"/>
    <dbReference type="eggNOG" id="COG1543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008192_1_0_12"/>
    <dbReference type="OMA" id="CAYYEGL"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037090">
        <property type="entry name" value="57_glycoside_trans_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015293">
        <property type="entry name" value="BE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040042">
        <property type="entry name" value="Branching_enz_MT3115-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41695">
        <property type="entry name" value="PTHR41695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09210">
        <property type="entry name" value="DUF1957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="3">
        <location>
            <begin position="7"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1957" evidence="4">
        <location>
            <begin position="423"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAS11583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="525" mass="60529" checksum="1B025428CFFEFBE3" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NR4</accession>
    <name>Q73NR4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_1088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971696.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002671768.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1088"/>
    <dbReference type="EnsemblBacteria" id="AAS11577">
        <property type="protein sequence ID" value="AAS11577"/>
        <property type="gene ID" value="TDE_1088"/>
    </dbReference>
    <dbReference type="GeneID" id="2739100"/>
    <dbReference type="KEGG" id="tde:TDE_1088"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1047"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1170086_0_0_12"/>
    <dbReference type="OMA" id="KAMDNID"/>
    <dbReference type="OrthoDB" id="1602781at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="226" mass="25976" checksum="56F2FD4325F4BCCE" modified="2004-07-05" version="1">MKALLISDLPRSTDDLQPLFSEYKFDLIHYRSPLKALDNIEEISPNIVLINTRDFPRHWKPITQHIRWDTSREEIPVILLTPSDFSADEADKAMFLGVQGIINLKENNNFNDDVLKELRMIFNRYNYNHIKNIEKSVQFLFTNPINETIITGTVKNLTENDIVFLPDMPANVGNLNAGMVLDQCSLKIEHNFIVPNCKIVSNDGILNLKFVDLSGEDKKTITDFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NU9</accession>
    <name>Q73NU9_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_1053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971661.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682360.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_1053"/>
    <dbReference type="EnsemblBacteria" id="AAS11542">
        <property type="protein sequence ID" value="AAS11542"/>
        <property type="gene ID" value="TDE_1053"/>
    </dbReference>
    <dbReference type="GeneID" id="2741327"/>
    <dbReference type="KEGG" id="tde:TDE_1053"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1013"/>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032129_0_0_12"/>
    <dbReference type="OMA" id="ERRAVYY"/>
    <dbReference type="OrthoDB" id="1131043at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284622" evidence="2">
        <location>
            <begin position="39"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="549"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="598" mass="66941" checksum="B9D217BDC66F5979" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-29" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73NV4</accession>
    <name>RS7_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsG</name>
        <name type="ordered locus">TDE_1048</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971656.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002670537.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73NV4"/>
    <dbReference type="SMR" id="Q73NV4"/>
    <dbReference type="STRING" id="243275.TDE_1048"/>
    <dbReference type="EnsemblBacteria" id="AAS11537">
        <property type="protein sequence ID" value="AAS11537"/>
        <property type="gene ID" value="TDE_1048"/>
    </dbReference>
    <dbReference type="GeneID" id="2741322"/>
    <dbReference type="KEGG" id="tde:TDE_1048"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.1008"/>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072226_1_1_12"/>
    <dbReference type="OMA" id="NVMPHVE"/>
    <dbReference type="OrthoDB" id="1540940at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000124372" description="30S ribosomal protein S7">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <sequence length="156" mass="17633" checksum="9366310E0D0F9669" modified="2004-07-05" version="1">MGRGKITARRPVAPDSKYNSVVVTRFIGRMMLSGKKSITTKIMYDSFDKIKEKTGEEPLAVFSKALDNVKPVVEVKSRRVGGATYQVPMDIPEGRREALAMRWIIGAARKRSGHEMSERLASELIDAYNNTGTAFKKKEEVHRMAEANKAFAHFRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q73P88</accession>
    <name>Q73P88_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type II restriction endonuclease TdeIII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tdeIIIR</name>
        <name evidence="1" type="ordered locus">TDE_0911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971521.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682206.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0911"/>
    <dbReference type="REBASE" id="6309">
        <property type="entry name" value="TdeIII"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS11402">
        <property type="protein sequence ID" value="AAS11402"/>
        <property type="gene ID" value="TDE_0911"/>
    </dbReference>
    <dbReference type="GeneID" id="2739951"/>
    <dbReference type="KEGG" id="tde:TDE_0911"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.882"/>
    <dbReference type="eggNOG" id="ENOG502Z9T1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086963_0_0_12"/>
    <dbReference type="OMA" id="EPAVMPF"/>
    <dbReference type="OrthoDB" id="1609391at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009036">
        <property type="term" value="F:type II site-specific deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019045">
        <property type="entry name" value="Restrct_endonuc_II_TdeIII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09520">
        <property type="entry name" value="RE_TdeIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS11402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="258" mass="29621" checksum="D05C825F01AC2E36" modified="2004-07-05" version="1">MSLSNQQIIQVEDILKQSLRHKFQNYNPEPAVMPFHTRLLGKDRMALFSFIHSLNTNFGTTIFEPVAVALAKTTFKSAEKQQTAGKTISSEAQNVIQTIMDDLTTGRQLPDKIQEIERIRAVCQKGEMKEVKPTKVDVKLVSKNDEMFLIDIKSAKPNIGEFKGFKRTLLEWVAVTLAEHPKAHIHTFLAIPYNPYEPKEYSRWTMRGMIDLEYELKVAAEFWDFLGGTGLYEALLNIFEKVGIELRPEIDAYFAQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PI4</accession>
    <name>Q73PI4_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">TDE_0815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971425.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682077.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0815"/>
    <dbReference type="EnsemblBacteria" id="AAS11306">
        <property type="protein sequence ID" value="AAS11306"/>
        <property type="gene ID" value="TDE_0815"/>
    </dbReference>
    <dbReference type="GeneID" id="2739557"/>
    <dbReference type="KEGG" id="tde:TDE_0815"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.787"/>
    <dbReference type="eggNOG" id="COG1288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035307_0_1_12"/>
    <dbReference type="OMA" id="GTRELKW"/>
    <dbReference type="OrthoDB" id="350103at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018385">
        <property type="entry name" value="C4_dicarb_anaerob_car-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018387">
        <property type="entry name" value="YcgA/YfcC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43652:SF6">
        <property type="entry name" value="PTHR43652:SF6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03606">
        <property type="entry name" value="DcuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAS11306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="462" mass="50708" checksum="D342A59E786D96EE" modified="2004-07-05" version="1">MTEKNKKKLKLPHLFFIMIGLIVIMSCLTYIIPAGKFYKDADGNIDASNFQFLETQQPVSLIKSMFMFMKGLVNSGLVVWVVMISGANMAVILETKSIDNFLNWATYKLEKQSIKVLIPVLYFLILYIAGFAGTDALIAVVPIGVIFAKKLKLDPISGLAATFFPSMIGFGMGPTLKVLIPQTMLGVESFSGFGLRFIMMNLFGIIGLMFTMSYVRKIEKDPNNSILGTDWLQEINSDEQFAKIELPVRSVIVLILTILQYIALVVYSLTVGTNIYEFLIGFFIVTSIIIGFIGGLSADQLGNSFAKGLGAMAFITFVIGLASTMQMIMVEGKILDTIVYFITKPLMNLNRGMSVIGITSVITILNPIVPSATAKAAVLMPILEPIAKTLGITSQVAVQAFLFGDAFTNMISPALGWTMGALTIAKVSYDKWFKWVIKPVIALILLSFVSVFLLDLISWTGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PK4</accession>
    <name>Q73PK4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1722 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971405.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682044.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0795"/>
    <dbReference type="EnsemblBacteria" id="AAS11286">
        <property type="protein sequence ID" value="AAS11286"/>
        <property type="gene ID" value="TDE_0795"/>
    </dbReference>
    <dbReference type="GeneID" id="2740673"/>
    <dbReference type="KEGG" id="tde:TDE_0795"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.768"/>
    <dbReference type="eggNOG" id="COG3272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147269_1_0_12"/>
    <dbReference type="OMA" id="NAFQHIW"/>
    <dbReference type="OrthoDB" id="1617908at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013560">
        <property type="entry name" value="DUF1722"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016996">
        <property type="entry name" value="UCP032441"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08349">
        <property type="entry name" value="DUF1722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032441">
        <property type="entry name" value="UCP032441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1722" evidence="1">
        <location>
            <begin position="16"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="128" mass="15312" checksum="63718D29F919A96B" modified="2004-07-05" version="1">MNDNKKISQKLWAQNKYLVLSKSQKIYKDIRALLKKEDIAPDEVQLLIDQAIKLEENPKEVINSLQHIWGYFKNCAEKNAKEKFLNMIELYKYGKINKKEILIYLLTLLKKYPNKYLEDSNIFKEEEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PK7</accession>
    <name>RL17_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplQ</name>
        <name type="ordered locus">TDE_0792</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971402.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002682042.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73PK7"/>
    <dbReference type="SMR" id="Q73PK7"/>
    <dbReference type="STRING" id="243275.TDE_0792"/>
    <dbReference type="EnsemblBacteria" id="AAS11283">
        <property type="protein sequence ID" value="AAS11283"/>
        <property type="gene ID" value="TDE_0792"/>
    </dbReference>
    <dbReference type="GeneID" id="2740670"/>
    <dbReference type="KEGG" id="tde:TDE_0792"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.765"/>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_0_1_12"/>
    <dbReference type="OMA" id="GRITTTM"/>
    <dbReference type="OrthoDB" id="1570391at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000055985" description="50S ribosomal protein L17">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="179" mass="20819" checksum="7B779362BD07CEE1" modified="2004-07-05" version="1">MKHKNGFNPLSRTTAHRRALHRNMVTSLFKYERITTTKQKAMEVRRTAEKLITRSKVDTFNNRRHAAKYIWDDDIVKKLFSDIGPRMKDRNGGYTRILKIGFREGDAADVAILELVDYDFEKKEKDTKKKDDSKKSDDKKTSKKEAGFKSSKGESEHKKNTDQVVDSSSNRRYNRVKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73PZ9</accession>
    <name>Q73PZ9_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OstA-like_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971259.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669890.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0645"/>
    <dbReference type="EnsemblBacteria" id="AAS11140">
        <property type="protein sequence ID" value="AAS11140"/>
        <property type="gene ID" value="TDE_0645"/>
    </dbReference>
    <dbReference type="GeneID" id="2740476"/>
    <dbReference type="KEGG" id="tde:TDE_0645"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.624"/>
    <dbReference type="eggNOG" id="COG1934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080451_1_0_12"/>
    <dbReference type="OMA" id="YIEARGN"/>
    <dbReference type="OrthoDB" id="1368384at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03968">
        <property type="entry name" value="LptD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OstA-like_N" evidence="2">
        <location>
            <begin position="45"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS11140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="238" mass="26993" checksum="87A11B3EE64B0183" modified="2004-07-05" version="1">MKKIQTEIRNHKSLKLLAAYLLIFLFLIDINAQTSTISFKADKVTASVSENKKSTNLIGNAEVKVDSLTISADRIEIFGKDYRYVNATGSVKGEDDEKGYSFKADLINFDRKTDTVTMFGKLELKDTKNDVSINAENIEYKKKQEIIIMRFNVKIINKDINCNSMFAFYNRKESKVELTGSPIVKKGKDEFRAGKISVNLDTEDITLDGRVRGSVEQGKDEPQAETKQEQNQEEKPND</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q60</accession>
    <name>Q73Q60_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_0584</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971198.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681755.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0584"/>
    <dbReference type="EnsemblBacteria" id="AAS11079">
        <property type="protein sequence ID" value="AAS11079"/>
        <property type="gene ID" value="TDE_0584"/>
    </dbReference>
    <dbReference type="GeneID" id="2741020"/>
    <dbReference type="KEGG" id="tde:TDE_0584"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.565"/>
    <dbReference type="eggNOG" id="COG0701">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039914_2_0_12"/>
    <dbReference type="OMA" id="IPMYICA"/>
    <dbReference type="OrthoDB" id="1559099at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS11079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="312" mass="34277" checksum="46D64C1C9BF40782" modified="2004-07-05" version="1">MLSLITTTNTIFLSILLQAFPFMLLGIVISSILHVFISGNFIVKVFPSRHGLGFLTAVFGGLVFPVCECASVPVLSGLVKKGVIMPIAVTFMLAAPILNPISIMATLYAFPESPMIAVYRVILGIVTAASIGMLLLFYPKNEYLKEGIENDNHCSCGCNCGDSCSASHGSGQRSFIENIKEMFLHSGTEFFNVGPYFILGALFTSLIRAGVPSNFFIQFNESHSLSGILIMMLFAFIFSACSTSDAFIARSFYGTFSLFSIMGFLVYGPMMDIKNIFMLLSIFKKRFVIELTIIITIMNIIFISTMSFLIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q73Q61</accession>
    <name>Q73Q61_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS11078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971197.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002669837.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0583"/>
    <dbReference type="EnsemblBacteria" id="AAS11078">
        <property type="protein sequence ID" value="AAS11078"/>
        <property type="gene ID" value="TDE_0583"/>
    </dbReference>
    <dbReference type="GeneID" id="2741019"/>
    <dbReference type="KEGG" id="tde:TDE_0583"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.564"/>
    <dbReference type="eggNOG" id="COG3689">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070027_0_1_12"/>
    <dbReference type="OMA" id="FMSCCIL"/>
    <dbReference type="OrthoDB" id="1505352at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015402">
        <property type="entry name" value="DUF1980"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40047">
        <property type="entry name" value="PTHR40047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09323">
        <property type="entry name" value="DUF1980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03943">
        <property type="entry name" value="TIGR03943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS11078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="257" mass="29873" checksum="FE00559DCFAAD7FF" modified="2004-07-05" version="1">MKKIFLSVFIEKIIRSLLLLIGSFIFIYAVVSQKALLYVHIRHIGIIIFSAIVFFIIGILTMRDAFYFPYHTHSKRKSPLYLIIFLLPILFALLIPYKALTSDSLAFNGDIFLFQKQKEEAGYNFNFRPSRLLELEDGFVVMDDETFGRWLPELYLNLDSWVNKKIKIEGSVWKNPEVLSENEFAIGRMLMVCCAADMQPAGLIAQWFKANELKEDDWVRVTGTISKIEYEGSFEPLIIVDNIEFIPRPALEYVYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QI6</accession>
    <name>Q73QI6_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PsbP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971071.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681554.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0457"/>
    <dbReference type="EnsemblBacteria" id="AAS10952">
        <property type="protein sequence ID" value="AAS10952"/>
        <property type="gene ID" value="TDE_0457"/>
    </dbReference>
    <dbReference type="GeneID" id="2740754"/>
    <dbReference type="KEGG" id="tde:TDE_0457"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.444"/>
    <dbReference type="eggNOG" id="ENOG5032MMT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1539347_0_0_12"/>
    <dbReference type="OrthoDB" id="2083280at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009654">
        <property type="term" value="C:photosystem II oxygen evolving complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002683">
        <property type="entry name" value="PsbP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01789">
        <property type="entry name" value="PsbP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="SSF55724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284644" description="PsbP domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="PsbP" evidence="2">
        <location>
            <begin position="22"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="174" mass="20223" checksum="8243AE65DBCA154E" modified="2004-07-05" version="1">MKKKLSILSFIFILISYLSSQDYYMDDFKDFTFEMPDGWETMTYPGLKYKIIYGDSVKGQNQNMIFVSEEVSGSMEEVVSEYLSGQKEPDDSASAYTVITQEKFENNYNLESRKIIIELPEGEGIAKHYFYLFKHNNILYICAATLSHDVEPEIVEMLDASMKTFQVLDKKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QJ3</accession>
    <name>Q73QJ3_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, M20/M25/M40 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971064.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681540.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0450"/>
    <dbReference type="EnsemblBacteria" id="AAS10945">
        <property type="protein sequence ID" value="AAS10945"/>
        <property type="gene ID" value="TDE_0450"/>
    </dbReference>
    <dbReference type="GeneID" id="2740432"/>
    <dbReference type="KEGG" id="tde:TDE_0450"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.437"/>
    <dbReference type="eggNOG" id="COG0624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_11_1_12"/>
    <dbReference type="OMA" id="WEAFGPF"/>
    <dbReference type="OrthoDB" id="906744at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="230"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="477" mass="53827" checksum="780F0A7C53741099" modified="2004-07-05" version="1">MNYFYLLFLLLVFPLVLLLRALTFKPKKPNKLIVENVDMDFDKAISRFSGMIKIPTVSHADVSLEDPSVFKKFQDYLNDAYPLVTKTCPRRILGPKGLLYHWKGKSSEKASVFMAHYDVVPVNREGWSRDPFGAEIIDNVLWGRGTLDTKCTLCGVMEAAEYLLSKGFVPEHDIYLSFSGDEEPHGPSCPAIVEELKKENINVEFVLDEGGAVVEGVFPGIKERFAVIGIGEKGQMDVELSMESKGGHASTPPKHTIVGKLAQAVCNIENNPLPMHVTPPVSAMFDVLGRHAGLGMRLVFANLKVFYPLFNMLTKKTGGELNAMLRTTTAVTKMSGSDAFNVIPPKASIGINIRYLAEDGRENIISHFKRVIKNEDVKIEVKYDEEPSRYSKIDSPEFELLSDAIRQTWEKTLVTPYLMMACSDSRHYSKISDKVYRFSAMHLTKEERGLIHGNDERIRLNEFKRTLAFFVRIMNKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QJ4</accession>
    <name>Q73QJ4_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferritin</fullName>
            <ecNumber evidence="1">1.16.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">TDE_0449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-storage protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 Fe(2+) + 6 H2O + O2 = 12 H(+) + 4 iron(III) oxide-hydroxide</text>
            <dbReference type="Rhea" id="RHEA:11972"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:78619"/>
            <dbReference type="EC" id="1.16.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferritin family. Prokaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.2" evidence="1"/>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971063.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681538.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0449"/>
    <dbReference type="EnsemblBacteria" id="AAS10944">
        <property type="protein sequence ID" value="AAS10944"/>
        <property type="gene ID" value="TDE_0449"/>
    </dbReference>
    <dbReference type="GeneID" id="2740431"/>
    <dbReference type="KEGG" id="tde:TDE_0449"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.436"/>
    <dbReference type="eggNOG" id="COG1528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065681_1_2_12"/>
    <dbReference type="OMA" id="CEDKGFE"/>
    <dbReference type="OrthoDB" id="1890523at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01055">
        <property type="entry name" value="Nonheme_Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001519">
        <property type="entry name" value="Ferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041719">
        <property type="entry name" value="Ferritin_prok"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11431">
        <property type="entry name" value="PTHR11431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0409">Iron storage</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAS10944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="160" mass="18372" checksum="743287994A6E13FB" modified="2004-07-05" version="1">MNEKITKALNEQINKEMESAYLYLGMAVHFETEALTGFAHWMQEQAKEEMEHALKIYRYLFEIGAKPVLGAIGAQSTEYGKPIDVIKKVLEHEKLVTASITSLYELALTEKDYKTQSFLTWFINEQVEEEANVTAILDKFKYIDNNTGLMILDKELGKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QJ8</accession>
    <name>Q73QJ8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">TDE_0445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_971059.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681529.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0445"/>
    <dbReference type="EnsemblBacteria" id="AAS10940">
        <property type="protein sequence ID" value="AAS10940"/>
        <property type="gene ID" value="TDE_0445"/>
    </dbReference>
    <dbReference type="GeneID" id="2740427"/>
    <dbReference type="KEGG" id="tde:TDE_0445"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.432"/>
    <dbReference type="eggNOG" id="COG0531">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_15_12_12"/>
    <dbReference type="OMA" id="FNSDNRV"/>
    <dbReference type="OrthoDB" id="527053at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAS10940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="426" mass="44802" checksum="8E379C590DBD9657" modified="2004-07-05" version="1">MENKGKLGLLSICLLGVNAIVGTGIFLLPGKAAKLVGVSSIGVILFDAVLVILIALCFAEAGGLFKKNGGPYVYAKEAFGEFVGFEVGFMKWAIMVIAWAAMAVGFPTALGSVFPLAATPFWRSVIAVAILLFLGLMNIAGVRISKIVNNVITIGKLVPLIFFILLGIFFIKGDNFQPMQSVGALTTTSFGAAALLIFYAFTGFESIAVAAEDMDKPEKNVPLAIVLVISGVSVFYILIQVVAIGILGDGLTASEAPVADAAAKFLGPVAKAVVTTGTLVSIGGINVASSFLAPRSAVALADDGFLPKFVTKRNKKDVPYISVILTTALTALVCLTGSFSKLAAISVVSRFAQYIPTCLAILVFRKRGMKGSFRIPGVYVVSFLAVGISLWLLYNSSWDKILFGLGGLVVGAVFYVIMKLTQKKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q73QT8</accession>
    <name>Q73QT8_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970969.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681340.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0355"/>
    <dbReference type="EnsemblBacteria" id="AAS10850">
        <property type="protein sequence ID" value="AAS10850"/>
        <property type="gene ID" value="TDE_0355"/>
    </dbReference>
    <dbReference type="GeneID" id="2740162"/>
    <dbReference type="KEGG" id="tde:TDE_0355"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.344"/>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120408_0_0_12"/>
    <dbReference type="OMA" id="TEIFFTW"/>
    <dbReference type="OrthoDB" id="1844961at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="190" mass="21498" checksum="653DBF33AB45AAD9" modified="2004-07-05" version="1">MFLLKLMESGREHLIGAFDSEANIKAFLEKIPGFEVYSDDEYGVLGKLHVAALGDLVEIAYGKKKFPLSRFSFVDDEAEAIAIEVEAFDDGKANTVEGCTLVDAYLIGNNELKTYIEKRERNFLRVKAVLEKKGFSVFREYHGSEDGEAVTYRDANGQYRFLMHMDPGFVDDLPEDDADLEVYISENENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R29</accession>
    <name>Q73R29_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Spermidine N1-acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">TDE_0263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970878.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0263"/>
    <dbReference type="EnsemblBacteria" id="AAS10759">
        <property type="protein sequence ID" value="AAS10759"/>
        <property type="gene ID" value="TDE_0263"/>
    </dbReference>
    <dbReference type="KEGG" id="tde:TDE_0263"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.258"/>
    <dbReference type="eggNOG" id="COG1670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_3_2_12"/>
    <dbReference type="OMA" id="FVHRNCE"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAS10759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="180" mass="21393" checksum="764FF09289B9915D" modified="2004-07-05" version="1">MESERIKLRPVQKDDLKKLAELMSDREIGVLSGEVYPITEKEMDNFYDRCQKIDDRIWFVIIDKETNSIIGETGFLRIFMPWRTADYSLMIWNRNYWAKGYGKETANLMLEYGFNSLNFHRIAIGVVGSNERGLRFWKSIGFKEEGKQKDGFFNNGKYSDFIMMYLLDEEYRVTRNNNKT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-07-09" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q73R77</accession>
    <name>CDGB_TREDE</name>
    <protein>
        <recommendedName>
            <fullName>Cyclic di-GMP binding protein TDE_0214</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">TDE_0214</name>
    </gene>
    <organism>
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="J. Bacteriol." volume="195" first="3897" last="3905">
            <title>Inactivation of cyclic Di-GMP binding protein TDE0214 affects the motility, biofilm formation, and virulence of Treponema denticola.</title>
            <authorList>
                <person name="Bian J."/>
                <person name="Liu X."/>
                <person name="Cheng Y.Q."/>
                <person name="Li C."/>
            </authorList>
            <dbReference type="PubMed" id="23794624"/>
            <dbReference type="DOI" id="10.1128/JB.00610-13"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>C-DI-GMP-BINDING</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
        <source>
            <strain>ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cyclic-di-GMP binding protein that plays important roles in motility, chemotaxis, biofilm formation and virulence.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="2">Mutants are less motile, reverse more frequently than the wild-type cells, and form less biofilm. Invasiveness and ability to induce skin abscesses and host humoral immune responses are significantly attenuated.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970830.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681114.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q73R77"/>
    <dbReference type="SMR" id="Q73R77"/>
    <dbReference type="STRING" id="243275.TDE_0214"/>
    <dbReference type="EnsemblBacteria" id="AAS10711">
        <property type="protein sequence ID" value="AAS10711"/>
        <property type="gene ID" value="TDE_0214"/>
    </dbReference>
    <dbReference type="GeneID" id="2739371"/>
    <dbReference type="KEGG" id="tde:TDE_0214"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.208"/>
    <dbReference type="eggNOG" id="ENOG502ZPJT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070336_0_0_12"/>
    <dbReference type="OMA" id="MMGVAKF"/>
    <dbReference type="OrthoDB" id="907046at2"/>
    <dbReference type="PHI-base" id="PHI:4141"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0973">c-di-GMP</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000429753" description="Cyclic di-GMP binding protein TDE_0214">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="PilZ">
        <location>
            <begin position="146"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="23794624"/>
        </source>
    </evidence>
    <sequence length="314" mass="34811" checksum="3E84CE5DFB3D0921" modified="2004-07-05" version="1">MAFAASQQLNRYYNLYKNIDVTFSKEVVSTLNFEPKQVFVRCSGGQWPCIINSASMTKAKIICGKKSGFLARLRSGITSVNIRFAFFDTEGKDSLSFFVAAKLVGISSYEAGNQDLVLITFEYTQRAPDDLIEKLGILLEANINSQKRRNERVVITPEISRKIGLVEKGTVVYIDAVPRRCLIRDLSFSGAKILLVGIANFLINKEVILRFAFDDPQSVFGIKGKTVRTEPVEGRKDLVALAVQYYPKNIPMMYKMYLNKYFSVVRKPASDGFGDDFLEDVAPASSFTPVSSPIGTNTAPLTPPPADSAPEQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RD1</accession>
    <name>Q73RD1_TREDE</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">TDE_0158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970775.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002681036.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10656">
        <property type="protein sequence ID" value="AAS10656"/>
        <property type="gene ID" value="TDE_0158"/>
    </dbReference>
    <dbReference type="GeneID" id="2741759"/>
    <dbReference type="KEGG" id="tde:TDE_0158"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.156"/>
    <dbReference type="eggNOG" id="ENOG50301U7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_193886_0_0_12"/>
    <dbReference type="OrthoDB" id="2070736at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAS10656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="74" mass="8787" checksum="702EFFD291B11094" modified="2004-07-05" version="1">MMTEMIVPPTTIELLSRGMECLIETMGVVEAEYFIAAVRRERFDYTKWQREYFDKMDLKTFVNNAKSHAQSMEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q73RH2</accession>
    <name>Q73RH2_TREDE</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">TDE_0116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)</name>
        <dbReference type="NCBI Taxonomy" id="243275"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Spirochaetes</taxon>
            <taxon>Spirochaetales</taxon>
            <taxon>Treponemataceae</taxon>
            <taxon>Treponema</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="5646" last="5651">
            <title>Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.</title>
            <authorList>
                <person name="Seshadri R."/>
                <person name="Myers G.S."/>
                <person name="Tettelin H."/>
                <person name="Eisen J.A."/>
                <person name="Heidelberg J.F."/>
                <person name="Dodson R.J."/>
                <person name="Davidsen T.M."/>
                <person name="DeBoy R.T."/>
                <person name="Fouts D.E."/>
                <person name="Haft D.H."/>
                <person name="Selengut J."/>
                <person name="Ren Q."/>
                <person name="Brinkac L.M."/>
                <person name="Madupu R."/>
                <person name="Kolonay J."/>
                <person name="Durkin S.A."/>
                <person name="Daugherty S.C."/>
                <person name="Shetty J."/>
                <person name="Shvartsbeyn A."/>
                <person name="Gebregeorgis E."/>
                <person name="Geer K."/>
                <person name="Tsegaye G."/>
                <person name="Malek J."/>
                <person name="Ayodeji B."/>
                <person name="Shatsman S."/>
                <person name="McLeod M.P."/>
                <person name="Smajs D."/>
                <person name="Howell J.K."/>
                <person name="Pal S."/>
                <person name="Amin A."/>
                <person name="Vashisth P."/>
                <person name="McNeill T.Z."/>
                <person name="Xiang Q."/>
                <person name="Sodergren E."/>
                <person name="Baca E."/>
                <person name="Weinstock G.M."/>
                <person name="Norris S.J."/>
                <person name="Fraser C.M."/>
                <person name="Paulsen I.T."/>
            </authorList>
            <dbReference type="PubMed" id="15064399"/>
            <dbReference type="DOI" id="10.1073/pnas.0307639101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <dbReference type="EMBL" id="AE017226">
        <property type="protein sequence ID" value="AAS10614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_970733.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_002673213.1">
        <property type="nucleotide sequence ID" value="NC_002967.9"/>
    </dbReference>
    <dbReference type="STRING" id="243275.TDE_0116"/>
    <dbReference type="TCDB" id="2.A.113.1.14">
        <property type="family name" value="the nickel/cobalt transporter (nico) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AAS10614">
        <property type="protein sequence ID" value="AAS10614"/>
        <property type="gene ID" value="TDE_0116"/>
    </dbReference>
    <dbReference type="GeneID" id="2741731"/>
    <dbReference type="KEGG" id="tde:TDE_0116"/>
    <dbReference type="PATRIC" id="fig|243275.7.peg.116"/>
    <dbReference type="eggNOG" id="COG2215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058605_4_0_12"/>
    <dbReference type="OMA" id="CSGAIMI"/>
    <dbReference type="OrthoDB" id="1515392at2"/>
    <dbReference type="Proteomes" id="UP000008212">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0533">Nickel</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004284662" description="Nickel/cobalt efflux system" evidence="8">
        <location>
            <begin position="25"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAS10614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000008212"/>
        </source>
    </evidence>
    <sequence length="293" mass="31810" checksum="C5FCE6B03D2FF74B" modified="2004-07-05" version="1">MKKKGIFVILFILNLALLSAKLSANPFTGKKNSPTPVYQGQPSENILKGQRILNQKLGDYINAWKENKNFAVLLSILALSFLYGLVHAAGPGHRKTIIFSFYLTKESKRLEPLFTGLALAGMHGGAAIVLMMIFKGLSGAILSRSNDAMIYMEGASFLILIILSLYGIIDAVKDINTKKDSNHKKLKLGAILLSGIYPCPAAMLVLVLAVSLNLLALGIFAVIAMSVGMSIPIIASGYLAWAGRTSLFYKLKGKERIIALIGSILQIGAYGFLLYISVKTALPFILSLFRMLK</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>